Halozyme Therapeutics, Inc
(NASDAQ:HALO)

Halozyme Therapeutics, Inc. operates as a biopharma technology platform company in the United States, Switzerland, Ireland, Belgium, Japan, and internationally. The company's products are based on the ENHANZE drug delivery technology, a patented recombinant human hyaluronidase enzyme (rHuPH20) that ...

Website: http://www.halozyme.com

Founded: 1998

Full Time Employees: 132

Sector: Healthcare

Industry: Biotechnology

Pharmaceuticals

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Unit: USD	2026-03-31	2025-12-31	2025-09-30	2025-06-30	2025-03-31	2024-12-31	2024-09-30	2024-06-30	2024-03-31	2023-12-31	2023-09-30	2023-06-30	2023-03-31	2022-12-31	2022-09-30	2022-06-30	2022-03-31	2021-12-31	2021-09-30	2021-06-30	2021-03-31	2020-12-31	2020-09-30	2020-06-30	2020-03-31	2019-12-31	2019-09-30	2019-06-30	2019-03-31	2018-12-31	2018-09-30	2018-06-30	2018-03-31	2017-12-31	2017-09-30	2017-06-30	2017-03-31	2016-12-31	2016-09-30	2016-06-30	2016-03-31	2015-12-31	2015-09-30	2015-06-30	2015-03-31	2014-12-31	2014-09-30	2014-06-30	2014-03-31	2013-12-31	2013-09-30	2013-06-30	2013-03-31	2012-12-31	2012-09-30	2012-06-30	2012-03-31	2011-12-31	2011-09-30	2011-06-30	2011-03-31	2010-12-31	2010-09-30	2010-06-30	2010-03-31	2009-12-31	2009-09-30	2009-06-30	2009-03-31	2008-12-31	2008-09-30	2008-06-30	2008-03-31	2007-12-31	2007-09-30	2007-06-30	2007-03-31	2006-12-31	2006-09-30	2006-06-30	2006-03-31

revenues
royalties	240,681,000	257,971,000	236,038,000	205,639,000	168,192,000	170,419,000	155,061,000	124,918,000	120,593,000	122,052,000	114,433,000	111,740,000	99,640,000	105,979,000	99,551,000	85,340,000	69,605,000	62,636,000	58,563,000	45,778,000	36,923,000	31,997,000	23,931,000	15,846,000	16,822,000	17,230,000	16,609,000	18,107,000	17,953,000	19,338,000	18,710,000	19,989,000	20,944,000	17,668,000	17,119,000	14,738,000	13,982,000	14,289,000	13,036,000	12,272,000	11,387,000	9,544,000	8,274,000	6,382,000	6,775,000	4,043,000	2,895,000	1,688,000	799,000
product sales	130,424,000	122,665,000	94,228,000	81,510,000	78,041,000	79,364,000	86,659,000	78,886,000	58,583,000	79,602,000	86,569,000	73,889,000	60,794,000	61,163,000	61,427,000	46,300,000	22,140,000	27,051,000	25,047,000	30,360,000	21,766,000	32,455,000	9,048,000	6,337,000	8,147,000	22,693,000	29,205,000	5,760,000	8,390,000	10,681,000	6,269,000	4,483,000	6,801,000	12,593,000	13,589,000	12,780,000	11,434,000	13,422,000	13,331,000	13,699,000	12,940,000	13,579,000	10,301,000	12,342,000	9,860,000	10,144,000	9,617,000	9,494,000	8,568,000	9,806,375	10,024,902	3,099,853	1,508,594	1,459,735	715,354	524,942	187,411	348,280	1,156,903	165,470	397,810	226,251	411,109	199,530	397,810	478,781	267,901	179,951	78,207	219,871	267,901	82,727	141,438	98,170	185,252	169,082	187,086	115,205	362,477	119,662	73,281
revenues under collaborative agreements	5,603,000	71,131,000	23,998,000	38,570,000	18,628,000	48,225,000	48,364,000	27,549,000	16,703,000	28,385,000	15,031,000	35,409,000	1,709,000	14,354,000	47,998,000	20,725,000	25,534,000	12,316,000	32,220,000	60,317,000	30,333,000	57,251,000	32,337,000	33,038,000	385,000	13,742,000	416,000	15,281,000	30,606,000	30,213,000	577,000	10,730,000	3,127,000	159,303,000	33,023,000	6,232,000	4,152,000	11,292,000	5,486,000	7,365,000	18,172,000	29,104,000	2,205,000	24,660,000	2,031,000	16,190,000	2,094,000	7,203,000	2,599,000	2,692,558	5,988,262	11,353,957	10,324,946	20,333,814	4,618,969	7,232,233	7,252,768	2,062,887	21,785,525	23,023,478	3,043,921	6,170,452	2,617,776	3,013,823	3,043,921					1,302,474.25	2,194,325	1,351,492	1,664,080	480,048	757,629	539,434
total revenues	376,708,000	451,767,000	354,264,000	325,719,000	264,861,000	298,008,000	290,084,000	231,353,000	195,879,000	230,039,000	216,033,000	221,038,000	162,143,000	181,496,000	208,976,000	152,365,000	117,279,000	102,003,000	115,830,000	136,455,000	89,022,000	121,703,000	65,316,000	55,221,000	25,354,000	53,665,000	46,230,000	39,148,000	56,949,000	60,232,000	25,556,000	35,202,000	30,872,000	189,564,000	63,731,000	33,750,000	29,568,000	39,003,000	31,853,000	33,336,000	42,499,000	52,227,000	20,780,000	43,384,000	18,666,000	30,377,000	14,606,000	18,385,000	11,966,000	12,498,933	16,013,164	14,453,810	11,833,540	21,793,549	5,334,323	7,757,175	7,440,179	2,411,167	22,942,428	23,188,948	3,441,731	6,396,703	3,028,885	3,213,353	3,441,731	7,969,342	2,462,226	1,426,156	2,772,371	3,062,176	2,462,226	1,434,219	1,805,518	1,337,909	942,881	708,516	810,215
yoy	42.23%	51.60%	22.12%	40.79%	35.22%	29.55%	34.28%	4.67%	20.81%	26.75%	3.38%	45.07%	38.25%	77.93%	80.42%	11.66%	31.74%	-16.19%	77.34%	147.11%	251.12%	126.78%	41.28%	41.06%	-55.48%	-10.90%	80.90%	11.21%	84.47%	-68.23%	-59.90%	4.30%	4.41%	386.02%	100.08%	1.24%	-30.43%	-25.32%	53.29%	-23.16%	127.68%	71.93%	42.27%	135.97%	55.99%	143.04%	-8.79%	27.20%	1.12%	-42.65%	200.19%	86.33%	59.05%	803.86%	-76.75%	-66.55%	116.18%	-62.31%	657.45%	621.64%	0.00%	-19.73%	23.01%	125.32%	24.14%	160.25%	0.00%	-0.56%	53.55%	128.88%	161.14%	102.43%	122.84%
qoq	-16.61%	27.52%	8.76%	22.98%	-11.12%	2.73%	25.39%	18.11%	-14.85%	6.48%	-2.26%	36.32%	-10.66%	-13.15%	37.15%	29.92%	14.98%	-11.94%	-15.11%	53.28%	-26.85%	86.33%	18.28%	117.80%	-52.76%	16.08%	18.09%	-31.26%	-5.45%	135.69%	-27.40%	14.03%	-83.71%	197.44%	88.83%	14.14%	-24.19%	22.45%	-4.45%	-21.56%	-18.63%	151.33%	-52.10%	132.42%	-38.55%	107.98%	-20.55%	53.64%	-4.26%	-21.95%	10.79%	22.14%	-45.70%	308.55%	-31.23%	4.26%	208.57%	-89.49%	-1.06%	573.76%	-46.20%	111.19%	-5.74%	-6.64%	-56.81%	223.66%	72.65%	-48.56%	-9.46%	24.37%	71.68%	-20.56%	34.95%	41.90%	33.08%	-12.55%
operating expenses
cost of sales	79,238,000	78,770,000	55,242,000	46,359,000	48,403,000	42,055,000	49,426,000	39,607,000	28,329,000	52,298,000	54,823,000	50,070,000	35,170,000	42,120,000	47,319,000	33,943,000																																																										29,229	59,454	75,518	76,228	41,399	356,093	16,538	22,959
amortization of intangibles	29,512,000	23,376,000	17,762,000	17,762,000	17,762,000	17,762,000	17,762,000	17,762,000	17,763,000	17,762,000	20,341,000	17,835,000	17,835,000	4,552,000	27,193,000	11,403,000
research and development	25,560,000	31,897,000	17,251,000	17,543,000	14,799,000	20,441,000	18,458,000	21,038,000	19,111,000	21,336,000	17,321,000	19,727,000	17,979,000	22,566,000	16,705,000	15,483,000	11,853,000	10,108,000	8,486,000	8,069,000	9,009,000	7,380,000	7,747,000	8,951,000	10,158,000	45,111,000	30,455,000	33,910,000	31,328,000	36,650,000	35,540,000	40,086,000	37,976,000	41,376,000	33,993,000	38,339,000	36,935,000	41,349,000	33,863,000	35,530,000	40,100,000	27,746,000	27,611,000	21,195,000	16,684,000	19,728,000	19,904,000	18,649,000	21,415,000	20,925,194	25,689,189	27,990,755	22,034,437	18,567,744	19,503,491	16,081,729	15,891,109	14,916,205	13,514,352	15,347,116	11,467,204	10,009,532	13,162,748	11,924,406	11,467,204	29,163,812	10,080,775	14,561,137	14,040,087	16,782,482	10,080,775	8,925,488	8,444,191	7,288,460	6,352,397	4,083,885	2,829,364	2,678,748	2,429,016	1,914,925	2,192,070
selling, general and administrative	57,881,000	77,028,000	46,088,000	41,614,000	42,362,000	42,249,000	41,241,000	35,711,000	35,134,000	37,608,000	35,269,000	38,948,000	37,357,000	37,749,000	34,467,000	57,476,000	13,834,000	13,774,000	13,169,000	12,321,000	11,059,000	10,427,000	11,702,000	10,975,000	12,632,000	23,929,000	17,979,000	17,338,000	18,006,000	18,031,000	14,864,000	14,353,000	13,556,000	14,771,000	13,329,000	13,101,000	12,615,000	12,227,000	11,599,000	11,221,000	10,806,000	10,589,000	10,226,000	9,814,000	9,399,000	8,353,000	8,587,000	8,752,000	10,250,000	9,356,971	8,135,118	7,299,754	7,555,905	6,979,034	5,634,034	5,580,424	6,618,707	5,866,921	4,263,520	4,567,666	3,757,013	4,029,397	3,703,099	3,357,486	3,757,013	3,749,180	3,450,450	3,903,642	3,486,822	3,179,353	3,450,450	3,846,175	4,157,603	3,947,650	2,840,683	2,381,827	1,985,034	2,374,984	1,403,405	1,603,172	1,531,292
total operating expenses	192,191,000	544,658,000	136,343,000	123,278,000	123,326,000	122,507,000	126,887,000	114,118,000	100,337,000	129,004,000	127,754,000	126,580,000	108,341,000	106,987,000	125,684,000	118,305,000	41,609,000	45,469,000	40,244,000	43,408,000	38,287,000	44,079,000	25,017,000	25,666,000	28,577,000	85,727,000	70,767,000	53,125,000	53,983,000	60,303,000	51,030,000	55,275,000	54,584,000	63,635,000	55,654,000	59,228,000	57,094,000	61,578,000	54,596,000	55,059,000	58,668,000	46,762,000	44,017,000	39,153,000	32,577,000	34,228,000	33,632,000	33,325,000	37,185,000	33,822,293	34,507,020	36,574,458	30,329,313	26,200,662	25,364,160	21,805,273	22,580,577	20,839,285	17,789,595	20,093,017	15,229,877	14,872,273	16,968,485	15,365,431	15,229,877	33,019,847	13,661,945	18,509,876	17,531,113	20,089,123	13,661,945	12,808,789	12,638,984	11,265,339	9,252,534	6,541,230
operating income	184,517,000	-92,891,000	217,921,000	202,441,000	141,535,000	175,501,000	163,197,000	117,235,000	95,542,000	101,035,000	88,279,000	94,458,000	53,802,000	74,509,000	83,292,000	34,060,000	75,670,000	56,534,000	75,586,000	93,047,000	50,735,000	77,624,000	40,299,000	29,555,000	-3,223,000	-32,062,000	-24,537,000	-13,977,000	2,966,000	-71,000	-25,474,000	-20,073,000	-23,712,000	125,929,000	8,077,000	-25,478,000	-27,526,000	-22,575,000	-22,743,000	-21,723,000	-16,169,000	5,465,000	-23,237,000	4,231,000	-13,911,000	-3,851,000	-19,026,000	-14,940,000	-25,219,000	-21,323,360	-18,493,856	-22,120,648	-18,495,773	-4,407,113	-20,029,837	-14,048,098	-15,140,398	-18,428,118	5,152,833	3,095,931	-11,788,146	-8,475,570	-13,939,600	-12,152,078	-11,788,146	-25,050,505	-11,199,719	-17,083,720	-14,758,742	-17,026,947	-11,199,719	-11,374,570	-10,833,466			-5,832,714
yoy	30.37%	-152.93%	33.53%	72.68%	48.14%	73.70%	84.87%	24.11%	77.58%	35.60%	5.99%	177.33%	-28.90%	31.80%	10.20%	-63.39%	49.15%	-27.17%	87.56%	214.83%	-1674.15%	-342.11%	-264.24%	-311.45%	-208.66%	45057.75%	-3.68%	-30.37%	-112.51%	-100.06%	-415.39%	-21.21%	-13.86%	-657.83%	-135.51%	17.29%	70.24%	-513.08%	-2.13%	-613.42%	16.23%	-241.91%	22.13%	-128.32%	-44.84%	-81.94%	2.88%	-32.46%	36.35%	383.84%	-7.67%	57.46%	22.16%	-76.08%	-488.72%	-553.76%	28.44%	117.43%	-136.97%	-125.48%	0.00%	-66.17%	24.46%	-28.87%	-20.13%	47.12%	0.00%	50.19%	36.23%			95.01%
qoq	-298.64%	-142.63%	7.65%	43.03%	-19.35%	7.54%	39.21%	22.71%	-5.44%	14.45%	-6.54%	75.57%	-27.79%	-10.54%	144.54%	-54.99%	33.85%	-25.21%	-18.77%	83.40%	-34.64%	92.62%	36.35%	-1017.00%	-89.95%	30.67%	75.55%	-571.24%	-4277.46%	-99.72%	26.91%	-15.35%	-118.83%	1459.11%	-131.70%	-7.44%	21.93%	-0.74%	4.70%	34.35%	-395.86%	-123.52%	-649.21%	-130.41%	261.23%	-79.76%	27.35%	-40.76%	18.27%	15.30%	-16.40%	19.60%	319.68%	-78.00%	42.58%	-7.21%	-17.84%	-457.63%	66.44%	-126.26%	39.08%	-39.20%	14.71%	3.09%	-52.94%	123.67%	-34.44%	15.75%	-13.32%	52.03%	-1.54%	4.99%
operating margin %	48.98%	-20.56%	61.51%	62.15%	53.44%	58.89%	56.26%	50.67%	48.78%	43.92%	40.86%	42.73%	33.18%	41.05%	39.86%	22.35%	64.52%	55.42%	65.26%	68.19%	56.99%	63.78%	61.70%	53.52%	-12.71%	-59.74%	-53.08%	-35.70%	5.21%	-0.12%	-99.68%	-57.02%	-76.81%	66.43%	12.67%	-75.49%	-93.09%	-57.88%	-71.40%	-65.16%	-38.05%	10.46%	-111.82%	9.75%	-74.53%	-12.68%	-130.26%	-81.26%	-210.76%	-170.60%	-115.49%	-153.04%	-156.30%	-20.22%	-375.49%	-181.10%	-203.50%	-764.28%	22.46%	13.35%	-342.51%	-132.50%	-460.22%	-378.17%	-342.51%	-314.34%	-454.86%	-1197.89%	-532.35%	-556.04%	-454.86%	-793.08%	-600.02%	0%	0%	-823.23%	0%	NaN%	NaN%	NaN%	NaN%
other income																																																																														135,007	175,000	182,182	182,846
investment and other income	1,318,000	2,430,000	5,333,000	6,891,000	6,818,000	7,253,000	6,474,000	5,032,000	4,993,000	5,360,000	4,786,000	3,192,000	2,979,000	852,000	641,000	-945,000	498,000	331,000	274,000	221,000	276,000	661,000	961,000	1,324,000	2,479,000	1,333,000	1,613,000	1,983,000	2,057,000	2,017,000	1,910,000	1,983,000	1,668,000	1,080,000	790,000	435,000	287,000	366,000	334,000	397,000	229,000	155,000	78,000	87,000	102,000	-45,000	122,000	118,000	47,000	64,685	51,424	58,132	54,988
interest expense	-5,508,000	-4,911,000	-4,296,000	-4,394,000	-4,525,000	-4,540,000	-4,524,000	-4,524,000	-4,507,000	-5,220,000	-4,505,000	-4,494,000	-4,543,000	-4,570,000	-7,514,000	-3,104,000	-1,759,000	-2,055,000	-1,754,000	-1,752,000	-1,965,000	-5,036,000	-4,990,000	-5,004,000	-5,348,000	-3,731,000	-2,078,000	-2,613,000	-3,205,000	-3,755,000	-4,286,000	-4,770,000	-5,230,000	-5,458,000	-5,538,000	-5,540,000	-5,448,000	-5,599,000	-5,253,000	-5,249,000	-3,876,000	-1,302,000	-1,301,000	-1,299,000	-1,299,000	-1,378,000	-1,376,000	-1,451,000	-1,376,000	-727,628	-849,936	-848,995	-847,584
income before income tax expense	180,327,000	-100,849,000	218,958,000	204,938,000	143,828,000	178,214,000	165,147,000
income tax expense	30,278,000	40,742,000	43,733,000	39,778,000	25,733,000	41,202,000	28,136,000	24,498,000	19,205,000	15,787,000	19,923,000	18,402,000	12,623,000	13,089,000	12,073,000	7,326,000	14,301,000	-11,960,000	-142,481,000	58,000	191,000	85,000	63,000	58,000	11,000	-63,000	13,000	17,000	22,000	317,000		33,000	187,000	-2,331,000	580,000	180,000	210,000	-422,000	1,284,000	300,000
net income	150,049,000	-141,591,000	175,225,000	165,160,000	118,095,000	137,012,000	137,011,000	93,245,000	76,823,000	85,388,000	81,837,000	74,754,000	39,615,000	57,702,000	61,634,000	22,685,000	60,108,000	66,770,000	216,587,000	91,458,000	27,895,000	73,164,000	36,207,000	25,817,000	-6,103,000	-34,397,000	-25,015,000	-14,624,000	1,796,000	-2,126,000	-27,850,000	-22,893,000	-27,461,000	123,882,000	2,749,000	-30,763,000	-32,897,000	-27,386,000	-28,946,000	-26,875,000	-19,816,000	4,318,000	-24,460,000	3,019,000	-15,108,000	-5,274,000	-20,280,000	-16,273,000	-26,548,000	-21,986,303	-19,292,368	-22,911,511	-19,288,369	-4,405,856	-20,005,846	-14,021,119	-15,119,181	-18,415,614	5,165,193	3,116,288	-11,787,477	-7,545,979	-13,910,282	-12,150,923	-11,787,477	-26,531,978	-10,872,158	-17,060,025	-14,725,364	-16,825,654	-10,872,158	-11,002,390	-9,953,997	-8,708,391	-7,028,782	-4,801,707	-3,357,304	-4,377,963	-3,651,037	-3,232,791	-3,490,194
yoy	27.06%	-203.34%	27.89%	77.12%	53.72%	60.46%	67.42%	24.74%	93.92%	47.98%	32.78%	229.53%	-34.09%	-13.58%	-71.54%	-75.20%	115.48%	-8.74%	498.19%	254.25%	-557.07%	-312.70%	-244.74%	-276.54%	-439.81%	1517.92%	-10.18%	-36.12%	-106.54%	-101.72%	-1113.10%	-25.58%	-16.52%	-552.36%	-109.50%	14.47%	66.01%	-734.23%	18.34%	-990.20%	31.16%	-181.87%	20.61%	-118.55%	-43.09%	-76.01%	5.12%	-28.97%	37.64%	399.02%	-3.57%	63.41%	27.58%	-76.08%	-487.32%	-549.93%	28.26%	144.05%	-137.13%	-125.65%	0.00%	-71.56%	27.94%	-28.78%	-19.95%	57.69%	0.00%	55.06%	47.93%	93.21%	54.68%	129.13%	196.49%	98.91%	92.51%	48.53%	-3.81%
qoq	-205.97%	-180.81%	6.09%	39.85%	-13.81%	0.00%	46.94%	21.38%	-10.03%	4.34%	9.48%	88.70%	-31.35%	-6.38%	171.69%	-62.26%	-9.98%	-69.17%	136.82%	227.87%	-61.87%	102.07%	40.24%	-523.02%	-82.26%	37.51%	71.05%	-914.25%	-184.48%	-92.37%	21.65%	-16.63%	-122.17%	4406.44%	-108.94%	-6.49%	20.12%	-5.39%	7.71%	35.62%	-558.92%	-117.65%	-910.20%	-119.98%	186.46%	-73.99%	24.62%	-38.70%	20.75%	13.96%	-15.80%	18.78%	337.79%	-77.98%	42.68%	-7.26%	-17.90%	-456.53%	65.75%	-126.44%	56.21%	-45.75%	14.48%	3.08%	-55.57%	144.04%	-36.27%	15.85%	-12.48%	54.76%	-1.18%	10.53%	14.30%	23.90%	46.38%	43.02%	-23.31%	19.91%	12.94%	-7.38%
net income margin %	39.83%	-31.34%	49.46%	50.71%	44.59%	45.98%	47.23%	40.30%	39.22%	37.12%	37.88%	33.82%	24.43%	31.79%	29.49%	14.89%	51.25%	65.46%	186.99%	67.02%	31.33%	60.12%	55.43%	46.75%	-24.07%	-64.10%	-54.11%	-37.36%	3.15%	-3.53%	-108.98%	-65.03%	-88.95%	65.35%	4.31%	-91.15%	-111.26%	-70.22%	-90.87%	-80.62%	-46.63%	8.27%	-117.71%	6.96%	-80.94%	-17.36%	-138.85%	-88.51%	-221.86%	-175.91%	-120.48%	-158.52%	-163.00%	-20.22%	-375.04%	-180.75%	-203.21%	-763.76%	22.51%	13.44%	-342.49%	-117.97%	-459.25%	-378.14%	-342.49%	-332.93%	-441.56%	-1196.22%	-531.15%	-549.47%	-441.56%	-767.13%	-551.31%	-650.90%	-745.46%	-677.71%	-414.37%	-Infinity%	-Infinity%	-Infinity%	-Infinity%
earnings per share
basic	1.27	-1.16	1.49	1.36	0.96	1.08	1.08	0.73	0.61	0.65	0.62	0.57	0.29
diluted	1.22	-1.12	1.43	1.33	0.93	1.06	1.05	0.72	0.6	0.65	0.61	0.56	0.29
weighted-average common shares outstanding
basic	118,144	119,840	117,219	121,343	123,215	126,827	126,850	127,116	126,941	131,927	131,965	131,730	135,027
diluted	122,875	123,904	122,331	124,158	126,644	129,424	130,134	129,222	128,887	134,197	134,083	133,543	137,900
contingent liability fair value measurement gain											13,200,000
net income before income taxes								117,743,000	96,028,000	101,175,000	101,760,000	93,156,000	52,238,000	70,791,000	73,707,000	30,011,000	74,409,000	54,810,000	74,106,000	91,516,000	28,086,000	73,249,000	36,270,000	25,875,000	-6,092,000				1,818,000	-19,496,000	-27,850,000									-26,575,000
inducement expense related to convertible notes															-2,712,000						-20,960,000
revenues:
operating expenses:
other income:
net income per share																																																																													-0.05	-0.07	-0.06	-0.05	-0.06
basic														0.43	0.45	0.16	0.44	0.47	1.53	0.64	0.2	0.54	0.27	0.19	-0.04				0.01	-0.01	-0.19			0.91	0.02					-0.21				0.02														-0.003	0.05	0.03
diluted														0.42	0.44	0.16	0.43	0.46	1.48	0.62	0.19	0.51	0.25	0.19	-0.04				0.01	-0.01	-0.19			0.9	0.02					-0.21				0.02														-0.003	0.05	0.03
shares used in computing net income per share:
basic														-526	136,527	137,937	137,658	-169	142,021	142,487	137,952	-369	136,578	135,935	137,186				144,743	203	143,949			1,786	141,190					127,958				126,144										27,664,689.25	112,305,002	112,063,665		25,570,726	103,223,352	102,671,410
diluted														-411	139,387	142,216	141,277	-856	146,690	147,624	148,540	1,492	142,081	138,084	137,186				147,474	203	143,949			4,435	143,236					127,958				134,507										27,664,689.25	112,305,002	112,063,665		25,570,726	105,009,189	104,393,835
cost of product sales																	15,922,000	21,587,000	18,589,000	23,018,000	18,219,000	26,272,000	5,568,000	5,740,000	5,787,000	16,687,000	22,333,000	1,877,000	4,649,000	5,622,000	626,000	836,000	3,052,000	7,488,000	8,332,000	7,788,000	7,544,000	8,002,000	9,134,000	8,308,000	7,762,000	8,427,000	6,180,000	8,144,000	6,494,000	6,147,000	5,141,000	5,924,000	5,520,000	3,540,128	682,713	1,283,949	738,971	653,884	226,635	143,120	70,761	56,159	11,723	178,235	5,660	833,344	102,638	83,539	5,660	106,855	130,720	45,097	4,204	127,288	130,720	37,126	37,190
net loss before income taxes																										-9,447,750	-25,002,000	-14,607,000				-22,860,000	-27,274,000			-30,583,000	-32,687,000	-27,808,000	-27,662,000
net income per share																																																																													-0.05	-0.07	-0.06	-0.05	-0.06
basic and diluted																										-0.065	-0.17	-0.1				-0.16	-0.19			-0.23	-0.26	-0.148	-0.23		-0.16	-0.073	-0.19
shares used in computing net loss per share:
basic and diluted																										36,358.75	146,136	145,411				143,568	142,656			134,013	128,615	31,971.5	128,154		127,615	31,531.75	126,921
income before income taxes																																		121,551,000	3,329,000																																														-3,490,194
basic and diluted net loss per share																																													-0.12	-0.04	-0.16	-0.13	-0.22	-0.19	-0.17	-0.2	-0.17				-0.14				-0.13	-0.02	-0.16	-0.13	-0.13	-0.27	-0.14	-0.21	-0.18	-0.21	-0.14	-0.14	-0.13	-0.11	-0.09	-0.07
shares used in computing basic and diluted net loss per share																																													125,299	533	124,041	123,710	118,943	250,992	112,765,155	112,486,211	112,416,792				107,589,514				91,610,830	9,271,239	89,570,540	91,766,799	91,610,830	7,316,480	80,293,800	82,990,107	82,429,868	460,093	80,293,800	79,454,496	78,300,319	1,058,800	76,502,867	73,217,967
interest and other income																																																						18,046.75	23,991	26,979	21,217	14,146.5	12,360	20,357	669	21,597.75	29,318	1,155	669
basic and diluted net income per share																																																						-0.11	-0.18	-0.13
comprehensive income																																																						-12,286,536.5	-20,005,846	-14,021,119
comprehensive loss																																																									-15,119,181
revenues under collaboration agreements																																																																		1,302,474.25	2,194,325	1,246,205	2,694,164
interest income																																																																		-1,481,473	327,561	23,695	33,378	138,293	327,561	372,180	879,469	1,219,039	1,280,871	1,031,007	723,107
income from operations																																																																										-4,555,694.25	-8,309,653		-4,080,411	-4,668,805	-3,826,037	-3,414,973	-3,673,040
revenue under collaborative agreements																																																																													623,129
expenses:
total expenses																																																																													4,890,626	5,095,131	4,188,514	3,534,635	3,746,321
net income per share																																																																													-0.05	-0.07	-0.06	-0.05	-0.06
shares used in computing net loss per share, basic and diluted																																																																													69,984,931	941,064	62,731,254	61,841,867	60,456,462

Balance Sheets:

Quarterly

Annual

Unit: USD	2026-03-31	2025-12-31	2025-09-30	2025-06-30	2025-03-31	2024-12-31	2024-09-30	2024-06-30	2024-03-31	2023-12-31	2023-09-30	2023-06-30	2023-03-31	2022-12-31	2022-09-30	2022-06-30	2022-03-31	2021-12-31	2021-09-30	2021-06-30	2021-03-31	2020-12-31	2020-09-30	2020-06-30	2020-03-31	2019-12-31	2019-09-30	2019-06-30	2019-03-31	2018-12-31	2018-09-30	2018-06-30	2018-03-31	2017-12-31	2017-09-30	2017-06-30	2017-03-31	2016-12-31	2016-09-30	2016-06-30	2016-03-31	2015-12-31	2015-09-30	2015-06-30	2015-03-31	2014-12-31	2014-09-30	2014-06-30	2014-03-31	2013-12-31	2013-09-30	2013-06-30	2013-03-31	2012-12-31	2012-09-30	2012-06-30	2012-03-31	2011-12-31	2011-09-30	2011-06-30	2011-03-31	2010-12-31	2010-09-30	2010-06-30	2010-03-31	2009-12-31	2009-09-30	2009-06-30	2009-03-31	2008-12-31	2008-09-30	2008-06-30	2008-03-31	2007-12-31	2007-09-30	2007-06-30	2007-03-31	2006-12-31	2006-09-30	2006-06-30	2006-03-31

assets
current assets
cash and cash equivalents	309,749,000	133,820,000	419,665,000	61,861,000	176,328,000	115,850,000	154,318,000	187,864,000	164,627,000	118,370,000	274,227,000	221,165,000	96,383,000	234,195,000	147,159,000	90,932,000	117,835,000	118,719,000	491,683,000	446,966,000	499,450,000	147,703,000	65,741,000	133,606,000	104,820,000	120,179,000	59,202,000	67,041,000	60,595,000	57,936,000	55,019,000	55,173,000	98,012,000	168,740,000	164,397,000	114,745,000	45,188,000		61,207,000	61,233,000	69,093,000		71,514,000	67,769,000	44,287,000		46,375,000	56,135,000	76,570,000	27,356,947	17,492,131	27,927,551	39,017,804	99,901,264	87,614,891	102,041,617	116,608,304	52,825,527	66,329,358	79,116,705	73,829,299	83,255,848	89,840,588	41,312,426	55,176,316	67,464,506	77,635,792	89,240,763	62,065,063	63,715,906	72,493,045	82,410,139	92,558,408	97,679,085	105,114,751	100,595,143	70,970,875	44,189,403	16,100,911	15,099,757	17,570,501
marketable securities, available-for-sale	8,873,000	9,000,000	282,298,000	486,316,000	571,594,000	480,224,000	511,988,000	341,166,000	298,824,000	217,630,000	209,055,000	127,110,000	179,225,000	128,599,000	118,425,000	118,428,000	668,305,000	622,203,000	324,237,000	308,343,000	264,856,000	220,310,000	280,965,000	251,840,000	263,363,000	301,083,000	178,796,000	220,424,000	268,122,000	296,590,000	309,347,000	343,721,000	335,682,000	300,474,000	152,525,000	182,788,000	133,797,000		159,845,000	168,757,000	169,545,000		52,204,000	72,946,000	84,212,000		88,089,000	91,513,000	87,919,000	44,145,697	47,818,851	48,082,636	48,408,220
accounts receivable, net and contract assets	457,989,000	441,273,000	346,035,000	316,339,000	304,621,000	308,455,000	285,743,000	214,524,000	195,902,000		217,325,000	246,179,000	194,883,000		233,302,000	189,368,000
inventories	155,467,000	176,475,000	185,796,000	181,505,000	164,868,000	141,860,000	131,412,000	159,312,000	168,541,000	127,601,000	128,921,000	132,406,000	107,521,000	100,123,000	103,276,000	97,615,000	47,761,000	53,908,000	55,978,000	58,554,000	58,343,000	60,747,000	57,697,000	48,271,000	41,452,000	29,359,000	36,051,000	43,900,000	31,241,000	22,625,000	18,285,000	8,404,000	4,393,000	5,146,000	9,331,000	15,172,000	14,290,000		12,852,000	10,755,000	10,345,000		11,101,000	7,723,000	7,482,000		6,916,000	7,114,000	6,765,000	6,169,982	3,846,290	2,466,999	2,737,387	2,670,696	2,186,063	1,783,894	1,496,783	567,263
prepaid expenses and other current assets	70,958,000	64,639,000	94,955,000	76,652,000	44,617,000	38,951,000	43,515,000	84,931,000	45,690,000	48,613,000	49,478,000	38,885,000	37,007,000	45,024,000	51,039,000	45,595,000
total current assets	1,003,036,000	825,207,000	1,328,749,000	1,122,673,000	1,262,028,000	1,085,340,000	1,126,976,000	987,797,000	873,584,000	746,424,000	879,006,000	765,745,000	615,019,000	739,013,000	653,201,000	541,938,000	988,689,000	926,287,000	1,017,299,000	999,750,000	941,719,000	554,764,000	498,895,000	500,358,000	467,971,000	543,436,000	342,041,000	391,706,000	409,036,000	427,849,000	429,926,000	462,032,000	484,470,000	510,372,000	353,345,000	340,834,000	222,354,000		272,605,000	284,344,000	297,035,000		153,090,000	168,442,000	153,329,000		158,600,000	175,623,000	190,914,000	95,195,394	102,818,028	100,420,847	111,110,478	131,027,935	105,618,569	119,731,075	132,565,976	63,987,497	76,968,519	88,013,451	79,192,091	89,498,434	98,430,800	49,324,302	62,677,320	74,441,743	83,405,811	93,648,975	66,180,998	74,012,788	78,229,346	86,116,203	96,620,736	101,177,058	108,075,769	102,944,110	73,294,524	45,593,550	17,332,034	16,453,870	18,581,699
property and equipment	82,230,000	82,137,000	71,420,000	71,520,000	72,816,000	75,035,000	74,490,000	75,000,000	78,071,000	74,944,000	74,669,000	74,559,000	77,964,000	75,570,000	36,674,000	37,091,000	8,513,000	8,794,000	9,588,000	10,132,000	10,366,000	10,593,000	10,252,000	11,169,000	11,752,000	10,855,000	15,398,000	15,079,000	14,542,000	7,465,000	6,790,000	4,789,000	4,937,000	3,520,000	3,232,000	3,330,000	3,741,000		4,407,000	4,682,000	4,440,000		2,686,000	2,594,000	2,732,000		3,249,000	3,343,000	3,628,000	3,421,506	4,935,928	4,576,506	3,975,052	3,700,462	2,363,650	2,016,809	2,152,934	1,771,048	1,274,753	1,495,639	1,741,192	1,846,899	1,960,935	2,161,549	2,486,127	2,708,016	2,703,592	2,646,666	2,745,803	2,549,925	2,523,767	2,439,765	2,251,099	2,283,316	1,916,932	1,182,661	572,026	497,770	460,834	369,442	367,142
prepaid expenses and other assets	50,915,000	53,551,000	55,698,000	56,371,000	55,609,000	80,596,000	80,151,000	52,481,000	17,319,000	17,816,000	18,115,000	18,409,000	25,240,000	26,301,000	25,783,000	26,283,000	41,026,000	40,482,000	33,302,000	32,691,000	30,679,000	28,274,000	31,941,000	29,240,000	28,587,000	33,373,000	27,248,000	28,122,000	20,914,000	20,693,000	19,619,000	21,152,000	19,809,000	13,879,000	12,397,000	13,656,000	16,627,000		6,062,000	3,632,000	22,509,000		9,879,000	10,266,000	9,623,000		8,945,000	7,966,000	8,704,000	8,425,684	9,139,014	11,111,833	10,571,334	12,752,888	11,353,342	10,218,468	8,910,059	8,332,242	4,297,814	4,317,105	3,382,993	3,720,896	4,891,556	4,676,229	4,320,707	1,573,777	2,942,015	2,711,585	3,072,336	2,591,149	3,715,018	1,895,820	2,252,861	2,014,680	1,830,827	1,326,775	1,295,675	428,268
goodwill	582,323,000	580,360,000	416,821,000	416,821,000	416,821,000	416,821,000	416,821,000	416,821,000	416,821,000	416,821,000	416,821,000	416,821,000	416,223,000	409,049,000	199,481,000	199,481,000
intangible assets	951,955,000	981,467,000	348,544,000	366,306,000	384,068,000	401,830,000	419,592,000	437,354,000	455,116,000	472,879,000	490,641,000	510,982,000	528,817,000	546,652,000	948,904,000	976,097,000
restricted cash	2,260,000	2,601,000											500,000	500,000	500,000	500,000	500,000	500,000	500,000	500,000	500,000	500,000	500,000	500,000	500,000	500,000	500,000	500,000	500,000	500,000	500,000	500,000	500,000	500,000	500,000	500,000	500,000		500,000	500,000	500,000		500,000	500,000	500,000		500,000	500,000	500,000	500,000	500,000	500,000	500,000
total assets	2,672,719,000	2,525,323,000	2,221,232,000	2,053,899,000	2,196,532,000	2,063,477,000	2,118,030,000	1,969,453,000	1,841,527,000	1,733,270,000	1,892,662,000	1,810,440,000	1,699,447,000	1,841,511,000	1,864,543,000	1,781,390,000	1,162,248,000	1,104,429,000	1,185,420,000	1,025,863,000	966,582,000	579,924,000	524,029,000	526,997,000	492,353,000	565,874,000	370,356,000	417,830,000	429,109,000	440,248,000	444,507,000	474,754,000	495,469,000	519,945,000	357,149,000	344,786,000	226,767,000	261,515,000	282,498,000	296,127,000	309,096,000	181,789,000	158,734,000	174,047,000	159,125,000	165,977,000	164,626,000	182,052,000	197,687,000	101,792,592	110,145,126	107,387,338	116,866,295	134,728,397	107,982,219	121,747,884	134,718,910	65,758,545	78,243,272	89,509,090	80,933,283	91,345,333	100,391,735	51,485,851	65,163,447	77,149,759	86,109,403	96,295,641	68,926,801	76,562,713	80,753,113	88,555,968	98,871,835	103,460,374	109,992,701	104,126,771	73,866,550	46,091,320	17,811,703	16,842,147	18,971,676
liabilities and stockholders’ equity
current liabilities
accounts payable	14,098,000	20,899,000	15,360,000	18,691,000	20,074,000	10,249,000	12,398,000	15,430,000	13,325,000	11,816,000	19,318,000	10,120,000	8,695,000	17,693,000	18,166,000	12,232,000	1,266,000	1,541,000	3,322,000	4,563,000	535,000	1,928,000	433,000	4,067,000	8,320,000	6,434,000	4,314,000	12,467,000	4,089,000	4,079,000	3,331,000	6,187,000	3,628,000	7,948,000	4,152,000	5,650,000	3,079,000		4,641,000	3,650,000	6,211,000		4,437,000	4,138,000	3,299,000		4,342,000	3,910,000	8,658,000	3,134,757	5,591,763	7,480,982	2,884,794	2,271,689	3,526,839	2,087,432	3,011,181	7,556,859	1,219,905	1,731,663	1,450,993	3,820,368	1,828,069	2,101,349	4,250,024	2,820,491	5,121,914	5,430,644	5,303,100	6,668,791	4,140,976	2,814,512	3,398,587	3,055,637	2,729,727	1,548,430	1,072,178	2,017,395	1,428,044	1,106,262	1,621,122
accrued expenses	140,369,000	156,193,000	111,183,000	115,591,000	130,305,000	128,851,000	96,417,000	117,930,000	118,314,000	100,678,000	95,200,000	105,431,000	79,978,000	96,516,000	74,317,000	84,101,000	19,133,000	24,441,000	18,335,000	19,274,000	16,098,000	20,483,000	25,795,000	21,258,000	26,811,000	55,649,000	45,679,000	45,561,000	43,663,000	49,529,000	43,020,000	35,030,000	31,889,000	39,601,000	32,370,000	26,934,000	24,935,000		25,733,000	23,851,000	21,791,000		18,926,000	14,821,000	12,813,000		15,023,000	16,455,000	12,272,000	14,920,446	20,624,501	15,289,431	9,177,574	7,783,447	8,041,673	7,529,322	7,184,794	5,615,574	8,864,705	9,465,723	8,238,267	8,605,569	5,052,723	4,134,661	4,084,015	6,083,854	5,749,610	4,721,593	4,473,621	3,995,897	3,705,304	3,338,896	2,942,071	2,502,259	1,976,594	1,454,459	1,187,146	1,011,153	1,206,630	928,258	818,007
current portion of long-term debt	208,743,000		710,685,000											13,334,000	13,315,000	99,048,000	89,546,000	89,419,000	89,251,000	89,167,000	89,042,000	397,228,000			2,859,000	19,542,000	54,537,000	70,878,000	86,663,000	91,506,000	88,521,000	86,965,000	82,460,000	77,211,000	61,433,000	45,515,000	29,601,000		12,394,000	3,288,000	27,417,000		15,699,000	9,656,000	3,730,000		10,075,000	6,203,000	2,404,000		5,970,119	3,643,156	1,362,055
total current liabilities	363,210,000	177,092,000	837,228,000	134,282,000	150,379,000	139,100,000	108,815,000	133,360,000	131,639,000	112,494,000	115,185,000	116,393,000	91,919,000	130,789,000	109,384,000	199,512,000	111,691,000	117,147,000	113,153,000	114,251,000	107,421,000	421,385,000	26,976,000	26,073,000	42,002,000	85,637,000	108,041,000	135,417,000	138,662,000	149,361,000	139,119,000	132,429,000	119,224,000	131,328,000	102,048,000	82,615,000	61,708,000		52,660,000	38,885,000	64,223,000		44,851,000	35,039,000	26,209,000		34,593,000	31,721,000	36,360,000	25,453,032	39,623,816	32,833,250	19,750,581	18,946,153	21,038,759	16,147,588	16,680,775	17,301,840	13,792,405	31,543,057	12,603,739	15,343,066	11,781,294	11,061,745	13,760,587	14,396,949	15,813,104	15,168,415	13,330,451	14,218,418	11,062,360	9,408,869	9,602,641	8,864,121	8,261,024	6,001,356	5,156,256	4,250,540	2,757,039	2,425,789	2,693,267
long-term debt	1,935,896,000	2,142,630,000	800,072,000	1,509,100,000	1,507,447,000	1,505,798,000	1,504,154,000	1,502,515,000	1,500,879,000	1,499,248,000	1,497,621,000	1,495,998,000	1,494,380,000	1,492,766,000	1,491,156,000	1,147,129,000	788,099,000	787,255,000	786,454,000	785,571,000	784,731,000		393,631,000	390,079,000	386,571,000	383,045,000	9,308,000	14,083,000	18,742,000	34,874,000	57,940,000	79,080,000	102,696,000	125,140,000	145,417,000	165,517,000	184,430,000	199,228,000	199,803,000	204,850,000	168,600,000	27,971,000	34,094,000	40,098,000	45,985,000	49,860,000	39,762,000	43,613,000	47,389,000	49,771,737	23,781,955	26,075,507	28,323,233	29,661,680
other long-term liabilities	106,448,000	113,863,000	71,799,000	77,769,000	56,436,000	54,758,000	40,406,000	30,507,000	31,201,000	37,720,000	28,422,000	30,875,000	29,573,000	30,433,000	5,418,000	5,551,000	171,000	544,000	1,609,000	2,267,000	2,809,000	3,466,000	3,793,000	4,627,000	5,097,000	4,180,000	6,407,000	6,532,000	7,149,000	2,118,000	2,203,000	2,314,000	2,479,000	814,000	540,000	710,000	326,000		1,178,000	600,000	3,906,000		3,746,000	3,429,000	3,127,000		2,759,000	2,854,000	2,343,000
deferred tax liabilities	47,529,000	42,924,000	8,218,000				11,952,000	13,647,000							28,989,000	3,288,000
total liabilities	2,453,083,000	2,476,509,000	1,717,317,000	1,721,151,000	1,714,262,000	1,699,656,000	1,665,327,000	1,680,029,000	1,663,719,000	1,649,462,000	1,643,481,000	1,659,407,000	1,633,597,000																									293,996,000				138,790,000				124,625,000
commitments and contingencies
stockholders’ equity																																						-32,481,000				42,999,000				41,352,000
preferred stock - 0.001 par value...
common stock - 0.001 par value...	118,000	118,000	118,000	118,000	123,000	123,000	127,000	127,000	127,000	127,000	132,000	132,000	132,000	135,000	135,000	138,000	138,000	138,000	141,000	142,000	143,000	135,000	135,000	137,000	135,000	137,000	147,000	146,000	145,000	145,000	145,000	144,000	144,000	143,000	142,000	142,000	130,000		129,000	129,000	129,000		128,000	128,000	127,000		125,000	125,000	124,000		113,987	113,286	113,143		112,693								100,384				91,095
additional paid-in capital	27,386,000	12,002,000	23,909,000		7,596,000		61,886,000	30,747,000	11,794,000	2,409,000	25,537,000	12,068,000		27,368,000	13,177,000	271,169,000	261,713,000	256,347,000	407,229,000	461,897,000	501,186,000	625,483,000	646,184,000	688,318,000	667,677,000	695,066,000	814,095,000	803,782,000	789,483,000	780,457,000	769,382,000	756,978,000	744,359,000	731,044,000	718,553,000	707,086,000	559,659,000		545,751,000	538,585,000	531,390,000		518,647,000	512,657,000	502,980,000		485,014,000	480,044,000	475,249,000	361,929,935	356,449,825	351,843,228	349,459,065	347,314,658	345,244,876	343,283,575	341,088,827	255,817,772	253,557,547	251,721,011	248,300,828	245,502,670	243,261,452	181,739,270	180,513,941	178,821,852	175,854,683	171,779,912	132,216,125	128,948,064	127,628,664	125,525,748	124,140,964	122,685,443	121,122,922	119,937,129
accumulated other comprehensive loss	-12,703,000						-6,939,000	-2,068,000	-1,486,000	-9,278,000		-1,615,000		-922,000	-1,836,000	-2,017,000	-2,791,000					22,000				240,000				-277,000	-478,000	-736,000	-870,000	-450,000	-53,000	-61,000	-49,000							-40,000	-27,000							-39,309	-29,131
retained earnings	204,835,000	54,786,000	502,146,000	361,033,000	477,964,000	359,869,000	397,629,000	260,618,000	167,373,000	90,550,000	222,285,000	140,448,000	65,694,000	143,217,000	85,515,000	23,881,000
total stockholders’ equity	219,636,000	48,814,000	503,915,000	332,748,000	482,270,000	363,821,000	452,703,000	289,424,000	177,808,000	83,808,000	249,181,000	151,033,000	65,850,000	169,798,000	96,991,000	293,171,000	260,256,000	196,953,000	281,674,000	119,748,000	67,595,000	151,047,000	98,988,000	105,577,000	58,042,000	91,765,000	245,353,000	260,052,000	260,047,000	248,887,000	239,738,000	254,925,000	265,064,000	208,366,000	72,389,000	58,165,000				9,920,000	29,472,000		31,799,000	50,229,000	37,545,000		39,940,000	55,299,000	66,748,000			11,143,677	31,681,060	48,853,719	51,189,777	69,234,318	81,060,411	10,900,116	27,055,163	20,053,396	13,515,349	20,351,456	35,003,715			6,903,389	16,600,485	26,434,558	3,924,086	15,379,996	30,885,809	39,654,037	49,271,052	57,767,924	64,912,893	70,755,192	40,903,649	23,081,235	15,054,664	14,416,358	16,278,409
total liabilities and stockholders’ equity	2,672,719,000	2,525,323,000	2,221,232,000	2,053,899,000	2,196,532,000	2,063,477,000	2,118,030,000	1,969,453,000	1,841,527,000	1,733,270,000	1,892,662,000	1,810,440,000	1,699,447,000	1,841,511,000	1,864,543,000	1,781,390,000	1,162,248,000	1,104,429,000	1,185,420,000	1,025,863,000	966,582,000	579,924,000	524,029,000	526,997,000	492,353,000	565,874,000	370,356,000	417,830,000	429,109,000	440,248,000	444,507,000	474,754,000	495,469,000	519,945,000	357,149,000	344,786,000				296,127,000	309,096,000		158,734,000	174,047,000	159,125,000		164,626,000	182,052,000	197,687,000			107,387,338	116,866,295	134,728,397	107,982,219	121,747,884	134,718,910	65,758,545	78,243,272	89,509,090	80,933,283	91,345,333	100,391,735			77,149,759	86,109,403	96,295,641	68,926,801	76,562,713	80,753,113	88,555,968	98,871,835	103,460,374	109,992,701	104,126,771	73,866,550	46,091,320	17,811,703	16,842,147	18,971,676
deferred tax assets				20,208,000	5,190,000	3,855,000			616,000	4,386,000	13,410,000	23,924,000	35,684,000	44,426,000			142,508,000	155,434,000	142,481,000
accumulated other comprehensive income		-18,092,000	-22,258,000	-28,403,000	-3,413,000	3,829,000							24,000					-620,000	-14,000	-24,000	-9,000		426,000	1,086,000	11,000		392,000	390,000	61,000										83,000	216,000	88,000						-46,000	3,000	-25,000	17,054	15,779
accounts receivable, net and other contract assets										234,210,000				231,072,000				90,975,000	112,099,000	153,196,000	88,391,000	97,730,000	62,551,000					32,219,000			27,656,000	33,582,000
contingent liability												13,888,000	15,472,000	15,472,000	129,772,000	130,000,000
deferred revenue, current portion											667,000	842,000	3,246,000	3,246,000	3,586,000	4,131,000	1,746,000	1,746,000	2,245,000	1,247,000	1,746,000	1,746,000	748,000	748,000	4,012,000	4,012,000	3,511,000	6,511,000	4,247,000	4,247,000	4,247,000	4,247,000	1,247,000	6,568,000	4,093,000	4,516,000	4,093,000		9,892,000	8,096,000	8,804,000		5,789,000	6,424,000	6,367,000		5,153,000	5,153,000	13,026,000	7,397,829	7,437,433	6,419,681	6,326,158	8,891,017	9,470,247	6,530,834	6,484,800	4,129,407
deferred revenue, net of current portion											2,253,000	2,253,000	2,253,000	2,253,000	2,833,000	2,739,000	2,031,000	2,530,000	2,530,000	4,026,000	4,026,000	4,026,000	641,000	641,000	641,000	1,247,000	1,247,000	1,746,000	4,509,000	5,008,000	5,507,000	6,006,000	6,006,000	54,297,000	36,755,000	37,779,000	38,802,000		40,849,000	41,872,000	42,895,000		44,244,000	45,252,000	46,259,000		47,572,000	48,565,000	44,847,000	45,745,449	45,940,511	33,681,996	34,318,481	34,954,966	34,883,135	35,506,951	36,130,767	36,754,583	36,667,445	37,279,394	54,447,803	55,176,422	53,024,341	53,857,056	53,830,590	54,989,588	52,747,933	53,667,269	50,628,280	45,894,726	37,731,528	38,376,170	38,992,374	35,963,266	36,287,055	27,370,223	27,806,645	18,759,545
accumulated other comprehensive gain											1,227,000
current assets:
current liabilities:
stockholders’ equity:
accounts receivable																	113,762,000							37,401,000	29,749,000	59,442,000	40,744,000		28,164,000	30,005,000			26,574,000	22,133,000	14,695,000	14,473,000	12,452,000		17,679,000	23,227,000	25,543,000		8,392,000	9,738,000	7,725,000		8,275,000	12,895,000	10,956,000	9,097,084	24,521,742	10,831,828	10,375,733	15,703,087	4,464,273	5,687,096	5,550,830	2,262,465	6,237,904	4,495,792	1,731,325	2,328,268	2,622,076	2,253,771	2,020,746	4,243,909	1,589,750	893,093	476,837	7,264,410	1,495,855	1,160,990	1,130,384	779,825	416,888	401,932	552,789	533,387
accumulated income																	1,196,000
accumulated deficit																		-58,912,000	-125,682,000	-342,267,000	-433,725,000	-474,593,000	-547,757,000	-583,964,000	-609,781,000	-603,678,000	-569,281,000	-544,266,000	-529,642,000	-531,438,000	-529,311,000	-501,461,000	-478,569,000	-522,371,000	-646,253,000	-649,002,000	-618,239,000		-557,955,000	-529,010,000	-502,135,000		-486,976,000	-462,516,000	-465,535,000		-445,153,000	-424,873,000	-408,600,000	-382,052,199	-360,065,896	-340,773,528	-317,862,017	-298,573,648	-294,167,792	-274,161,946	-260,140,827	-245,021,646	-226,606,032	-231,771,225	-234,887,512	-225,251,795	-208,358,121	-195,948,545	-183,797,622	-172,010,145	-159,345,293	-145,435,011	-128,374,986	-113,649,622	-96,823,968	-85,951,810	-74,949,420	-64,995,423	-56,287,032	-49,258,251	-44,456,544	-41,099,240	-36,721,277	-33,070,239	-29,837,448
liabilities and stockholders’ deficit
stockholders’ deficit:
total stockholders’ deficit																																					-58,499,000
total liabilities and stockholders’ deficit																																					226,767,000
cash and cash equivalents and available-for-sale marketable securities																																						204,981,000				108,339,000				135,623,000
working capital																																						201,947,000				109,315,000				136,990,000
deferred revenue																																						44,618,000				53,223,000				54,634,000													3,707,795	20,345,671	2,914,479	2,917,129	4,900,502	4,825,735	5,426,548	5,492,604	4,941,580	5,016,178	3,553,730	3,553,730	3,216,080	3,255,461	3,261,983	3,306,225	3,554,703	2,998,467	2,896,932	1,221,992	122,365	391,269	254,138
prepaid manufacturing costs																																							14,960,000	16,740,000
liabilities and stockholders’ (deficit) equity
stockholders’ (deficit) equity:
total stockholders’ (deficit) equity																																							-11,992,000											-19,990,676	-3,486,305													-14,117,265	-3,191,799
total liabilities and stockholders’ (deficit) equity																																							282,498,000											101,792,592	110,145,126													51,485,851	65,163,447
lease financing obligation																																																			2,550,000	2,100,000	1,450,000	1,450,000
deferred rent, net of current portion																																																		794,782	813,689	874,208	906,091	861,879	870,548	859,027	846,957	802,006	728,259	633,243	366,392	474,389	582,385	684,315	764,069	859,833	947,881	1,025,399	1,043,984	1,069,573	1,073,416	1,116,892	1,005,768	865,063	531,729
other long-term liability																																																		18,268	921,460	678,700	436,849
preferred stock — 0.001 par value...
common stock — 0.001 par value...																																																		114,534				112,709			112,411	103,990	103,648	103,610	102,033	100,581		92,010	91,882	91,682		89,657	82,947	81,554	81,113	80,099	79,508	77,904	77,003
preferred stock – 0.001 par value...
common stock – 0.001 par value...																																																								112,689
inventory																																																											103,443	83,849	248,474	193,422	1,076,580	1,081,876	1,159,551	1,159,551	1,238,254	803,534	566,762	441,323	525,428	649,254	679,083	703,468	713,303	620,260	475,185	442,492	233,767	414,059	286,189
preferred stock — .001 par value...
common stock — .001 par value...																																																																												76,314
preferred stock, 0.001 par value...
common stock, 0.001 par value...																																																																													71,531	68,737	64,449	62,052	61,348
additional paid-in-capital																																																																													85,288,662	64,111,738	51,711,492	47,424,545	46,054,509
other assets																																																																															18,835	18,835	22,835
receivables																																																																															384,206	400,652	119,686
prepaid expenses																																																																															613,150	539,402	605,323

Cashflow Statements:

Quarterly

Annual

Unit: USD	2026-03-31	2025-12-31	2025-09-30	2025-06-30	2025-03-31	2024-12-31	2024-09-30	2024-06-30	2024-03-31	2023-12-31	2023-09-30	2023-06-30	2023-03-31	2022-12-31	2022-09-30	2022-06-30	2022-03-31	2021-12-31	2021-09-30	2021-06-30	2021-03-31	2020-12-31	2020-09-30	2020-06-30	2020-03-31	2019-12-31	2019-09-30	2019-06-30	2019-03-31	2018-12-31	2018-09-30	2018-06-30	2018-03-31	2017-12-31	2017-09-30	2017-06-30	2017-03-31	2016-12-31	2016-09-30	2016-06-30	2016-03-31	2015-12-31	2015-09-30	2015-06-30	2015-03-31	2014-12-31	2014-09-30	2014-06-30	2014-03-31	2013-12-31	2013-09-30	2013-06-30	2013-03-31	2012-12-31	2012-09-30	2012-06-30	2012-03-31	2011-12-31	2011-09-30	2011-06-30	2011-03-31	2010-12-31	2010-09-30	2010-06-30	2010-03-31	2009-12-31	2009-09-30	2009-06-30	2009-03-31	2008-12-31	2008-09-30	2008-06-30	2008-03-31	2007-12-31	2007-09-30	2007-06-30	2007-03-31	2006-09-30	2006-06-30	2006-03-31

operating activities
net income	150,049,000	-141,591,000	175,225,000	165,160,000	118,095,000	137,012,000	137,011,000	93,245,000	76,823,000	85,388,000	81,837,000	74,754,000	39,615,000	57,702,000	61,634,000	22,685,000	60,108,000	66,770,000	216,587,000	91,458,000	27,895,000	73,164,000	36,207,000	25,817,000	-6,103,000				1,796,000
adjustments to reconcile net income to net cash from operating activities:
share-based compensation	16,637,000	16,571,000	12,160,000	12,161,000	10,673,000	11,462,000	12,578,000	9,471,000	9,874,000	9,664,000	9,368,000	9,622,000	7,966,000	7,223,000	6,797,000	5,635,000	4,742,000	5,126,000	5,399,000	5,372,000	4,923,000	4,196,000	4,220,000	4,257,000	4,531,000	7,229,000	8,239,000	9,833,000	9,475,000	9,012,000	8,867,000	9,478,000	8,339,000	7,402,000	7,762,000	8,191,000	7,315,000	6,742,000	6,655,000	6,371,000	5,817,000	5,250,000	5,553,000	5,905,000	4,130,000	4,209,000	4,176,000	3,594,000	3,295,000	2,398,058	2,303,662	2,439,649	2,396,687	1,986,215	1,922,392	2,285,052	2,154,928	1,653,570	1,757,359	1,227,900	931,070	1,120,349	1,325,690	1,191,500	1,228,786	1,607,955	1,047,309	1,048,810	821,956	805,198	960,851	1,066,277	863,516	790,948	732,792
depreciation and amortization	4,221,000	3,304,000	2,658,000	2,740,000	2,687,000	2,653,000	2,598,000	2,569,000	2,443,000	2,931,000	2,737,000	2,793,000	2,622,000	2,562,000	2,010,000	1,143,000	778,000	773,000	751,000	735,000	738,000	800,000	803,000	824,000	857,000	1,042,000	1,002,000	1,034,000	990,000	590,000	612,000	620,000	566,000	493,000	496,000	570,000	602,000	644,000	654,000	623,000	489,000	459,000	402,000	395,000	421,000	458,000	464,000	443,000	397,000	333,450	301,777	297,036	294,664	283,261	286,168	272,202	237,793	244,210	238,682	286,750	326,181	343,763	364,533	389,372	410,257	395,176	368,491	351,432	328,639	290,789	280,504	248,379	228,206	213,529	153,196	123,131	86,635	172,702	109,640	52,985
amortization of intangible assets	29,512,000	23,376,000	17,762,000	17,762,000	17,762,000	17,762,000	17,762,000	17,762,000	17,763,000	17,762,000	20,341,000	17,835,000	17,835,000	4,552,000	27,193,000
amortization of debt discount	2,245,000	1,950,000	1,858,000	1,852,000	1,846,000	1,844,000	1,841,000	1,835,000	1,830,000	1,828,000	1,824,000	1,817,000	1,835,000	1,832,000	3,925,000	1,111,000	971,000	968,000	968,000	965,000	741,000	3,596,000	3,552,000	3,510,000	3,478,000	1,721,000	209,000	248,000	306,000
accretion of premium on marketable securities	-30,000	-96,000	-357,000	-1,134,000	-1,709,000
lease payments recognized	214,000	271,000	170,000	257,000	253,000	204,000	354,000					301,000	320,000
deferred income taxes	3,428,000	-16,768,000	27,354,000	-7,094,000	-2,858,000	-15,292,000	292,000	14,241,000	1,291,000	9,423,000	9,702,000	11,507,000	3,874,000	14,676,000	25,701,000	-13,298,000	12,926,000	-12,953,000
changes in operating assets and liabilities
accounts receivable, net and contract assets	-19,547,000
inventories	27,379,000	18,781,000	-1,101,000	-14,540,000	-586,000	-7,726,000	1,980,000	-21,402,000	-40,233,000	1,469,000	3,634,000	-24,737,000	-7,250,000	-2,945,000	-5,511,000	-15,323,000	6,298,000	2,219,000	2,725,000	-86,000	2,513,000	-3,050,000	-9,426,000	-6,819,000	-12,093,000	6,692,000	7,849,000	-12,659,000	-8,616,000	-4,341,000	-9,881,000	-4,010,000	752,000	4,185,000	5,841,000	-882,000	333,000	-1,771,000	-2,097,000	-410,000	-856,000	1,612,000	-3,378,000	-241,000	-1,076,000	510,000	198,000	-349,000	-595,000	-2,323,692	-1,379,291	270,388	-66,691	-484,633	-402,169	-287,111	-929,520
prepaid expenses and other assets	-9,108,000	28,424,000	-20,319,000	-36,068,000	-4,995,000	5,621,000	38,483,000	-43,543,000	4,795,000	-1,201,000	-8,450,000	4,868,000	8,881,000	5,295,000	-5,040,000	-151,000	-9,168,000	-5,042,000	-682,000	-3,496,000	-2,335,000	4,085,000	-2,010,000	-3,390,000	3,833,000	-4,696,000	-770,000	-12,722,000	-818,000	1,782,000	1,676,000	-3,214,000	-5,939,000	-6,963,000	1,309,000	3,021,000	4,668,000	4,541,000	965,000	2,642,000	-2,522,000	-14,774,000	436,000	-593,000	-843,000	-363,000	-674,000	1,024,000	-252,000	-59,278	1,964,119	-1,157,225	1,210,965	-1,399,546	-1,134,874	-1,308,409	-577,817	-4,034,428	-596,562	-318,259	337,903	1,170,660	-215,327	-355,522	-2,746,930	1,368,238	-230,430	360,751	-481,187	1,123,869	-1,819,198	357,041	-238,181	-177,350	-504,052	-31,100	-704,088	-327,959	-254,212	-324,132
accounts payable and accrued expenses	-24,922,000	33,849,000	-7,164,000	-29,693,000	9,219,000	50,186,000	-23,182,000	1,304,000	18,685,000	-9,479,000	-1,951,000	22,890,000	-24,006,000	326,000	-5,114,000	35,333,000	-6,010,000	3,473,000	-2,513,000	6,833,000	-6,626,000	-1,074,000	-2,610,000	-9,903,000	-27,621,000	11,447,000	-8,496,000	9,568,000	-7,881,000	9,851,000	2,892,000	5,514,000	-12,561,000	11,416,000	3,610,000	5,016,000	-4,413,000	1,157,000	3,410,000	-246,000	-4,565,000	7,855,000	4,320,000	2,900,000	-1,209,000	-2,509,000	-1,481,000	-245,000	3,419,000	-8,182,186	3,540,633	10,549,196	1,980,892	-1,156,733	1,494,709	7,708	-3,609,171	2,895,641	-1,100,514	1,688,431	-2,771,781	5,621,096	522,732	-2,068,744	-637,995	-1,817,319	433,115	522,042	-1,138,071	2,702,412	1,719,623	-416,451	782,762	851,575	1,703,432	743,565	-769,224	585,444	-14,709	389,899
net cash from operating activities	180,078,000	219,029,000	178,597,000	99,711,000	154,221,000	178,467,000	115,376,000	55,794,000	129,427,000	102,354,000	132,411,000	66,842,000	86,964,000		69,635,000	40,225,000	47,797,000	82,516,000	121,739,000	36,889,000	58,296,000		6,084,000	3,294,000	-4,844,000	-26,625,000	-29,588,000	-24,786,000	-4,424,000	10,462,000	-18,927,000	-18,858,000	-22,177,000	153,249,000	20,259,000	-16,996,000	-22,459,000	-15,767,000	-8,748,000	-12,845,000	-13,023,000	-15,197,000	-16,985,000	8,938,000	-13,839,000	-939,000	-13,183,000	-15,766,000	-17,630,000	-15,219,954	-12,413,897	-10,954,726	-10,750,902	-16,918,390	-14,298,123	-13,755,168	-19,357,615	-13,553,841	-13,443,456	3,738,938	-11,092,066	-7,375,069	-11,616,065	-13,791,719	-12,602,653	-10,967,720	-14,482,926	-10,918,229	-3,779,390	-9,039,412	-10,624,822	-10,200,362	-5,509,268	-7,625,669	4,953,385	-3,653,501	6,178,125	-9,076,490	-6,278,350	-2,802,115
capital expenditures	-1,994,000	-1,427,000	-2,493,000	-1,770,000	-462,000	-3,092,000	-1,695,000	-3,599,000	-2,030,000	-2,596,000	-2,944,000	1,888,000	-10,987,000		-1,008,000	-941,000	-181,000	-158,000	-636,000	-579,000	18,000		199,000	-706,000	233,000	-641,000	-1,398,000	-1,023,000	-727,000	-3,073,000	-333,000	-418,000	-839,000	-860,000	-161,000	-230,000	-99,000	-447,000	-424,000	-1,167,000	-1,099,000	-1,634,000	-336,000	-260,000	-130,000	-236,000	-371,000	-350,000	-411,000	-1,358,079	-325,159	-80,183	-534,097	-894,787	298,355	-585,416	628,535	-374,043	-60,458	-17,881	-186,228	-426,636	41,463	-142,954	-104,611	-727,134	123,527	-603,221	-110,700	-193,018	-505,271	-267,005	-205,018	-582,471	-887,467	0	-160,891	-255,456	-99,239	-38,879
free cash flows	178,084,000	217,602,000	176,104,000	97,941,000	153,759,000	175,375,000	113,681,000	52,195,000	127,397,000	99,758,000	129,467,000	68,730,000	75,977,000		68,627,000	39,284,000	47,616,000	82,358,000	121,103,000	36,310,000	58,314,000		6,283,000	2,588,000	-4,611,000	-27,266,000	-30,986,000	-25,809,000	-5,151,000	7,389,000	-19,260,000	-19,276,000	-23,016,000	152,389,000	20,098,000	-17,226,000	-22,558,000	-16,214,000	-9,172,000	-14,012,000	-14,122,000	-16,831,000	-17,321,000	8,678,000	-13,969,000	-1,175,000	-13,554,000	-16,116,000	-18,041,000	-16,578,033	-12,739,056	-11,034,909	-11,284,999	-17,813,177	-13,999,768	-14,340,584	-18,729,080	-13,927,884	-13,503,914	3,721,057	-11,278,294	-7,801,705	-11,574,602	-13,934,673	-12,707,264	-11,694,854	-14,359,399	-11,521,450	-3,890,090	-9,232,430	-11,130,093	-10,467,367	-5,714,286	-8,208,140	4,065,918	-3,653,501	6,017,234	-9,331,946	-6,377,589	-2,840,994
investing activities
purchases of marketable securities	-8,846,000	0	-4,956,000	-102,760,000	-139,639,000	-51,444,000	-303,974,000	-93,420,000	-198,763,000	-21,294,000	-161,698,000	0	-109,919,000	-29,519,000	0	-40,874,000	-184,815,000	-369,161,000	-41,428,000	-120,946,000	-120,980,000	-64,697,000	-83,251,000	-14,980,000	-63,257,000	-148,177,000	-7,898,000	-66,014,000	-167,670,000	-38,469,000	-62,728,000	-95,254,000	-114,661,000	-199,439,000	-36,856,000	-107,062,000	-54,830,000	-3,008,000	-14,005,000	-11,968,000	-126,431,000	-25,122,000	-13,176,000	1,000	-33,185,000	233,000	-1,000	-24,111,000	-65,005,000	0	0	-1	-48,946,615
proceeds from sales and maturities of marketable securities	9,000,000	273,375,000	209,595,000	189,111,000	50,167,000	83,976,000	138,008,000	53,963,000	119,627,000	15,599,000	81,192,000	53,371,000	61,134,000		0
proceeds from working capital adjustments on acquisition	710,000
purchases of property and equipment	-3,741,000	-1,427,000	-3,030,000	-1,563,000	-950,000	-3,052,000	-1,517,000	-2,582,000	-3,545,000	-2,596,000	-2,944,000	1,623,000	-11,377,000	-2,344,000	-1,008,000	-968,000	-490,000	-158,000	-496,000	-533,000	-270,000	-1,699,000	-176,000	-515,000	-114,000	-641,000	-1,104,000	-1,368,000	-927,000	-3,073,000	-333,000	-418,000	-839,000	-860,000	-161,000	-230,000	-99,000	-447,000	-424,000	-1,167,000	-1,099,000	-1,634,000	-336,000	-260,000	-130,000	-236,000	-371,000	-350,000	-411,000	-1,358,079	-325,159	-80,183	-534,097	-539,420	-167,516			-556,987	-38,959	-29,539	-203,023	-330,737	-60,639	-106,128	-149,040	-563,367	-150,945	-427,758	-318,951	-252,370	-435,351	-267,005	-205,018	-582,471	-887,467
net cash from investing activities	-2,877,000	-741,788,000	201,609,000	84,788,000	-90,422,000	29,480,000	-167,483,000	-42,039,000	-82,681,000	-8,291,000	-83,450,000	54,994,000	-60,162,000	-1,746,000	-1,008,000	-434,946,000	-49,305,000	-299,469,000	-16,954,000	-44,616,000	-45,250,000	58,441,000	-30,095,000	11,899,000	38,109,000	-122,818,000	40,999,000	47,457,000	28,813,000	10,809,000	35,191,000	-7,607,000	-35,900,000	-148,988,000	30,283,000	-49,292,000	4,265,000	21,045,000	8,246,000	-435,000	-105,622,000	-14,756,000	20,293,000	10,771,000	-10,420,000	13,482,000	2,628,000	-5,870,000	-43,191,000	2,016,921	-325,159	-80,184	-49,480,712	-539,420	-167,516	-721,493	15,844	-556,987	-38,959	-29,539	-203,023	-330,737	-60,639	-106,128	-149,040	-563,367	-150,945	-427,758	-318,951	-252,370	-435,351	-267,005	-205,018	-582,471	-887,467	-734,497	-160,891	-255,456	-99,239	-38,879
financing activities
taxes paid related to net share settlement, net of proceeds from issuance of common stock under equity incentive plans	-1,613,000								-489,000
net cash from financing activities	-1,613,000	239,515,000	-22,402,000	-298,966,000	-3,321,000	-246,415,000	18,561,000	9,482,000	-489,000	-249,920,000	4,101,000	2,446,000	-164,614,000	6,329,000	-12,400,000	367,818,000	624,000	-156,011,000	-60,068,000	-44,757,000	338,701,000	-27,399,000	-43,854,000	13,593,000	-48,624,000	210,420,000	-19,250,000	-16,225,000	-21,730,000	-18,354,000	-16,418,000	-16,374,000	-12,651,000	82,000	-890,000	135,845,000	-3,382,000	279,000	476,000	5,420,000	144,446,000	1,731,000	437,000	3,773,000	7,157,000	2,471,000	795,000	1,201,000	110,034,000	23,067,849	2,303,636	-55,343	-251,846	29,744,183	38,913	-90,026	83,124,548	606,997	695,068	1,578,007	1,868,540	1,121,066	60,204,866	33,957	463,503	1,359,801	3,028,900	38,521,687	2,447,498	514,643	1,143,079	319,098	593,609	772,474	453,690	34,012,266	20,764,238	6,300,663	2,345,152	1,279,301
net increase in cash and cash equivalents	175,588,000		357,804,000																																			5,557,000	-26,000	-7,860,000	25,801,000	-28,222,000	3,745,000	23,482,000	-17,102,000	15,014,000	-9,760,000	-20,435,000	49,213,000	9,864,816	-10,435,420	-11,090,253	-60,483,460	12,286,373	-14,426,726	-14,566,687	63,782,777	-13,503,831				-6,584,740	48,528,162			-10,171,286	-11,604,971			-8,777,139	-9,917,094	-10,148,269	-5,120,677	-7,435,666	4,519,608	29,624,268	26,781,472
cash and cash equivalents at beginning of period	136,421,000		0																																			0	0	0	43,292,000	0	0	0	61,389,000	0	0	0	27,357,000	0	0	0	99,501,264	0	0	0	52,825,527	0	0	0	83,255,848	0	0	0	67,464,506	0	0	0	63,715,906	0	0	0	97,679,085		0
cash and cash equivalents at end of period	312,009,000		357,804,000																																			5,557,000	-26,000	-7,860,000	69,093,000	-28,222,000	3,745,000	23,482,000	44,287,000	15,014,000	-9,760,000	-20,435,000	76,570,000	9,864,816	-10,435,420	-11,090,253	39,017,804	12,286,373	-14,426,726	-14,566,687	116,608,304	-13,503,831	-12,787,347	5,287,406	73,829,299	-6,584,740	48,528,162	-13,863,890	55,176,316	-10,171,286	-11,604,971	27,175,700	62,065,063	-8,777,139	-9,917,094	-10,148,269	92,558,408		4,519,608
reconciliation of cash, cash equivalents and restricted cash to the condensed consolidated balance sheets
cash and cash equivalents	309,749,000
restricted cash	2,260,000																																																	0	0	0	-100,000
total cash, cash equivalents and restricted cash	312,009,000
supplemental disclosure of non-cash investing and financing activities
amounts accrued for purchases of property and equipment	1,747,000		537,000	-207,000	488,000	-40,000	-178,000	-1,017,000	1,515,000			265,000	390,000			27,000	309,000		-140,000	-46,000	288,000		375,000	-191,000	347,000		-294,000	345,000	200,000
right-of-use assets obtained in exchange for lease obligation	170,000		-307,000	637,000	95,000	456,000	1,156,000	224,000	1,242,000			631,000	406,000						0	139,000	179,000		52,000	20,000	1,589,000		732,000	0	165,000
realized gain on marketable securities						0	0	0	-7,000
loss on disposal of equipment						-149,000	0			94,000	0			49,000	0	0	80,000																	2,000	0	0	44,000																					-574	-336	0	-656	5,111	-1,178	4,508	5,101	0	0	0	2,685	-5,225	925	0	9,029	2,558	0			3,168	1,405
contingent liability fair value measurement adjustment										0
induced conversion expense related to 2027 and 2028 convertible notes
acquired in-process research and development expense
impairment of intangible asset
accounts receivable, net and other contract assets		-90,483,000	-29,696,000	-11,718,000	3,834,000	-22,712,000	-71,220,000	-18,621,000	38,308,000	-16,885,000	28,853,000	-51,496,000	36,189,000		-43,934,000	-9,465,000	-22,787,000		41,097,000	-64,805,000	9,339,000										5,926,000
acquisition of business, net of cash acquired
acquisition of in-process research and development, net of cash acquired
repayment of 2024 convertible notes										0	0	0	-13,483,000
repayment of 2027 convertible notes
repayment of 2028 convertible notes
proceeds from issuance of 2031 convertible notes
proceeds from issuance of 2032 convertible notes
payment for the induced conversion of 2027 and 2028 convertible notes
premium on repayment of 2027 convertible notes settled in cash
premium on repayment of 2028 convertible notes settled in cash
purchase of capped calls on 2031 convertible notes
purchase of capped calls on 2032 convertible notes
payment of debt issuance cost														-639,000	-462,000			0	0	-95,000	-329,000				-68,000
repurchase of common stock		0	-38,883,000							-252,300,000	0	0	-150,083,000	-1,000				-160,321,000	-64,716,000	-48,842,000	-76,179,000	-40,147,000	-56,400,000	-1,996,000	-51,574,000
proceeds from issuance of common stock under equity incentive plans, net of taxes paid related to net share settlement		4,146,000	16,481,000			3,585,000	18,561,000			2,380,000	4,101,000	2,446,000	-1,048,000	6,969,000	2,636,000	3,821,000	624,000	4,310,000	4,648,000	4,180,000	-602,000	12,748,000	12,546,000	18,382,000	19,717,000	8,131,000	2,075,000	4,467,000	-449,000	2,063,000	3,538,000	3,141,000	4,977,000	5,090,000	3,703,000	4,376,000	-393,000
net increase in cash, cash equivalents and restricted cash					60,478,000	-38,468,000	-33,546,000	23,237,000	46,257,000	-155,857,000				87,036,000	56,227,000	-26,903,000	-884,000	-372,964,000	44,717,000	-52,484,000	351,747,000	81,962,000	-67,865,000	28,786,000	-15,359,000	60,977,000	-7,839,000	6,446,000	2,659,000	2,917,000	-154,000			4,343,000	49,652,000	69,557,000	-21,576,000
cash, cash equivalents and restricted cash at beginning of period					115,850,000	0	0	0	118,370,000	0	0	0	234,695,000	0	0	0	119,219,000	0	0	0	148,203,000	0	0	0	120,679,000	0	0	0	58,436,000	0	0	0	169,240,000	0	0	0	67,264,000
cash, cash equivalents and restricted cash at end of period					176,328,000	-38,468,000	-33,546,000	23,237,000	164,627,000	-155,857,000	53,062,000	124,282,000	96,883,000	87,036,000	56,227,000	-26,903,000	118,335,000	-372,964,000	44,717,000	-52,484,000	499,950,000	81,962,000	-67,865,000	28,786,000	105,320,000	60,977,000	-7,839,000	6,446,000	61,095,000	2,917,000	-154,000	-42,839,000	98,512,000	4,343,000	49,652,000	69,557,000	45,688,000
reconciliation of cash, cash equivalents and restricted cash to the consolidated balance sheets
realized loss on marketable securities			47,000											0	0
taxes paid related to net share settlement, net of proceeds from issuance of common stock under equity incentive plan					-3,321,000
accretion of (premium) discount on marketable securities
recognition of deferred revenue											-175,000			-921,000	-451,000	-623,000	-499,000	-499,000	-498,000			-249,000	0	-3,264,000	-606,000	501,000	-3,499,000	-499,000	-499,000	-499,000	-499,000	0	-1,834,000	-2,320,000	-1,869,000	-600,000	-1,723,000
induced conversion expense related to convertible notes														0				0	0	0	20,960,000
other														1,000				1,000				0	-3,000	-6,000	-4,000	-6,000	-9,000	-3,000	11,000	1,000	3,000	-11,000	-2,000	-10,000	-13,000	12,000	-5,000
acquisitions of business, net of cash acquired														0	0
proceeds from sale of assets
proceeds from term loan														0	0
repayment of term loan														0
proceeds from revolving credit facilities														0	0
repayment of revolving credit facilities														0
proceeds from issuance of 2028 convertible notes														0
purchase of capped call														0
supplemental disclosure of cash flow information
interest paid
income taxes paid
common stock issued for conversion of 2024 convertible notes												0	125,000
adjustments to reconcile net income to net cash from operating activities
accretion of discount on marketable securities							-3,121,000
amortization of premium on marketable securities									-2,365,000
lease payments deferred									220,000					-265,000	-244,000	-211,000	-183,000	-183,000	-183,000	-182,000	-203,000		-270,000	-268,000	-221,000
amortization of (premium) discounts on marketable securities										-2,489,000	-1,488,000	-1,425,000	-917,000
proceeds from issuance of 2027 convertible notes
adjustments to reconcile net income to net cash from in operating activities:
changes in operating assets and liabilities:
proceeds from the sale of assets															0
payment of debt issuance costs
net decrease in cash, cash equivalents and restricted cash												124,282,000	-137,812,000																				-70,728,000
supplemental disclosure of non-cash investing and financing activities:
operating activities:
amortization of (accretion of discounts) premiums on marketable securities
deferral of unearned revenue																														0	0			22,337,000
loss on impairment of right-of-use asset																						52,000
accounts receivable																						-35,179,000	-25,150,000	-7,652,000	29,693,000	-18,698,000			1,841,000				15,044,000	-7,438,000	-222,000	-2,021,000	3,228,000	1,998,000	5,549,000	2,316,000	6,867,000	-24,018,000	1,346,000	-2,013,000	1,424,000	-874,000	4,620,000	-1,939,000	-1,859,000	15,424,658	-13,689,914	-456,095	5,327,354	-11,238,814	1,222,823	-136,266	-3,288,365	3,975,439	-1,742,112	-2,764,467	596,943	293,808	-368,305	-233,025	2,223,163	-2,654,159	-696,657	-416,256	6,787,573	-5,768,555	-334,865	-30,606	-350,559	-369,440	-14,956	150,857	-182,721	29,623	13,177	294,143
net cash provided by operating activities
investing activities:
proceeds from maturities of marketable securities																	136,000,000	69,850,000	24,970,000	76,863,000	76,000,000	124,622,000	53,209,000	27,394,000	100,742,000	26,000,000	50,001,000	114,839,000	197,410,000	52,351,000	98,252,000	88,065,000	79,600,000	51,311,000	67,300,000	58,000,000	59,194,000	24,500,000	22,675,000	12,700,000	21,908,000	12,000,000	33,805,000	11,030,000	22,895,000	13,485,000	3,000,000	18,591,000	22,225,000
financing activities:
repayment of long-term debt																		0	0	0	-369,064,000	0	0	-2,861,000	-16,699,000	-44,784,000	-21,325,000	-20,692,000	-21,281,000	-20,417,000	-19,956,000	-19,515,000	-17,628,000	-5,007,000	-4,595,000	-3,404,000	-2,989,000	35,000	-35,000	-50,365,000	-3,885,000
accretion of discounts on marketable securities															185,000	259,000	541,000		573,000	594,000	351,000		280,000	188,000	9,000		-472,000	-797,000	-936,000
common stock issued for induced conversion related to convertible notes																			0	0	7,865,000
adjustments to reconcile net income to net cash from (used) in operating activities:
proceeds from issuance of long-term debt																		0	0	0	784,875,000																	1,000	0	54,959,000	148,046,000
debt issuances cost included in accounts payable																					95,000
amortization of premiums (accretion of discounts) on marketable securities
loss on extinguishment of debt
proceeds from disposal of property and equipment																						215,000	123,000	0	738,000
gain on disposal of equipment																							-34,000	0	-597,000																														378
pending settlement of common stock repurchase
deferral of lease payments																												-110,000	-93,000
net cash provided (used in) by operating activities
adjustments to reconcile net loss to net cash from operating activities:
(accretion of discounts) amortization of premiums on marketable securities																																-705,000	-565,000	-209,000
lease payments (deferred) recognized																										-155,000
recognition of deferred rent																																		-60,000	-56,000	45,000	-114,000
proceeds from issuance of common stock																																		-1,000	2,000											0	0	0	107,713,000					0	0	0	81,476,845					0				0	0							0	0
net loss																											-25,015,000				-27,850,000	-22,893,000	-27,461,000		2,749,000	-30,763,000	-32,897,000	-27,386,000	-28,946,000	-26,875,000	-19,816,000	4,318,000	-24,460,000	3,019,000	-15,108,000	-5,274,000	-20,280,000	-16,273,000	-26,548,000	-21,986,303	-19,292,368	-22,911,511	-19,288,369	-4,405,856	-20,005,846	-14,021,119	-15,119,181	-18,415,614	5,165,193	3,116,287	-9,635,717	-16,893,674	-12,409,576	-12,150,923	-11,787,477	-12,664,852	-13,910,282	-17,060,025	-14,725,364	-16,825,654	-10,872,158	-11,002,390	-9,953,997	-8,708,391	-7,028,781	-4,801,707	-3,357,304	-10,374,023	-6,722,985	-3,490,194
leasehold improvements paid by lessor
non-cash interest expense																														-455,000	303,000	345,000	1,352,000	519,000	386,000	369,000	487,000	452,000	601,000	789,000	1,054,000	358,000	357,000	356,000	172,000	415,000	432,000	432,000	746,000	-880,693	283,686	282,732	470,084
payment-in-kind interest expense on long-term debt																																						4,032,000	3,674,000	3,588,000	1,890,000
deferral of rent expense
deferral (recognition) of rent expense																															-80,000	26,000	132,000
amortization of premiums on marketable securities																																				46,000	16,000	47,000	108,000	184,000	213,000	180,000	151,000	223,000	325,000	395,000	375,000
proceeds from issuance of common stock under equity incentive plans																																						243,000	511,000	826,000	285,000	1,731,000	437,000	3,773,000	7,157,000	2,471,000	-137,000	1,280,000	3,174,000	3,082,599	1,929,851	9,319	57,277	83,583
supplemental disclosure of cash flow information:
deferred revenue																																							772,000	-1,730,000	-1,524,000	3,189,000	-1,643,000	-950,000	-2,007,000	1,908,000	-993,000	-4,154,000	4,729,000	-234,666	13,276,267	-542,962	-3,201,344	-507,399	2,315,597	-577,782	1,731,577	508,750	-17,249,825	262,783	-731,269	168,708	-757,948	-574,347	-1,225,054	2,792,679	-993,934	4,501,437	4,733,554	8,500,848	-684,023	-622,726	2,984,866	-572,267	9,473,068	-334,887	10,722,040	-131,773	137,131
other liabilities																																							-93,000	-97,000	-70,000	366,000	-69,000	-63,000	-68,000	-47,000	-20,000	-21,000	73,000
capitalized property and liability associated with a build-to-suit lease arrangement																																																		-2,550,000	450,000
payments for tax withholding for restricted stock units vested																																																-79,000	-853,000			-64,662	-309,123
amortization of discount on investments																																																	-1,035,000
amortization of premiums on investments, net of accretion of discounts																																																		299,429	318,873	315,407	181,916
deferred rent																																																		-8,731	-41,341	-41,341	42,940	-17,490	2,699	10,557	49,129	82,985	104,253	74,888	-89,688	-88,048	-81,982	-72,213	-72,504	-74,141	-65,818	10,352	16,264	52,801	-307	170,285	140,705	333,334
proceeds from sales of marketable securities
gain on disposals of equipment																																																									-6,988
interest and fees paid																																																			566,250	566,250	396,938
property and equipment purchases in accounts payable and accrued expenses																																																			-113,960	168,307	35,157
proceeds from disposals of property and equipment																																																									15,844
long-term debt, non-cash interest expense
accounts payable for purchases of property and equipment																																																						-355,367	465,871	-585,416	628,535	182,944	-21,499	11,658	16,795	-95,899	102,102	-36,826	44,429	-163,767	274,472	-175,463	208,251	59,352	-69,920
adjustments to reconcile net loss to net cash from operating activies:
proceeds from exercise of stock options and restricted stock units
proceeds from exercise of stock options																																																									1,647,703			1,578,007	1,868,540	1,121,066	239,807	33,957	463,503	250,872	186,186	347,316	233,983	85,780	92,711	71,616	593,609	136,958	109,484	1,000,977	459,918	137,258
inventory																																																										-463,820	-19,594	164,625	-55,052	883,158	5,296			78,703	-434,720	-236,772	-125,439	84,105	123,826	29,829	24,385	9,835	-93,043	-145,075	-32,693	45,191	-135,101	-7,231
proceeds from exercise of warrants																																																																		1,108,929	2,842,714	0	2,213,515	428,863	1,050,368			635,516	344,206	968,212	357,909
proceeds from exercises of stock options
net decrease in cash and cash equivalents																																																												5,287,406	-9,426,549				-12,288,190				-1,650,843									-3,031,283	-4,032,437	-1,561,693
adjustments to reconcile net loss to net cash (used in) provided by operating activities:
issuance of stock options for services
cash and cash equivalents at beginning of year
cash and cash equivalents at end of year
cash flows from operating activities:
share-based compensation expense																																																																													415,480	911,815	577,982	273,092
issuance of common stock and stock options for goods and services																																																																														9,322	9,322	9,323
cash flows from investing activities:
purchase of property and equipment																																																																													-160,891	-255,456	-99,239	-38,879
cash flows from financing activities:
proceeds from issuance of common stock — net																																																																													19,946,411
cash and cash equivalents, beginning of period																																																																													44,189,403	19,132,194	19,132,194	19,132,194
cash and cash equivalents, end of period																																																																													70,970,875	16,100,911	15,099,757	17,570,501
proceeds from exercise of stock options — net																																																																															35,975
proceeds from exercise of warrants — net																																																																														6,163,405	2,309,177	1,279,301
contributed capital — net
cash and cash equivalents, beginning of year
cash and cash equivalents, end of year
supplemental disclosures of cash flow information:
non cash investing and financing activities:
conversion of contributed capital to common stock
conversion of series c preferred stock to common stock
accrued cost for redemption of unexercised callable warrants
cash paid for income taxes

Halozyme Therapeutics, Inc(NASDAQ:HALO)

Halozyme Therapeutics, Inc
(NASDAQ:HALO)