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Unit: USD	2025-09-30	2025-06-30	2025-03-31	2024-12-31	2024-09-30	2024-06-30	2024-03-31	2023-12-31	2023-09-30	2023-06-30	2023-03-31	2022-12-31	2022-09-30	2022-06-30	2022-03-31	2021-12-31	2021-09-30	2021-06-30	2021-03-31	2020-12-31	2020-09-30	2020-06-30	2020-03-31	2019-12-31	2019-09-30	2019-06-30	2019-03-31	2018-12-31	2018-09-30	2018-06-30	2018-03-31	2017-12-31	2017-09-30	2017-06-30	2017-03-31	2016-09-30	2016-06-30	2016-03-31	2015-09-30	2015-06-30	2015-03-31	2014-09-30	2014-06-30	2014-03-31	2013-09-30	2013-06-30	2013-03-31	2012-09-30	2012-06-30	2012-03-31	2011-12-31	2011-09-30	2011-06-30	2011-03-31	2010-12-31	2010-09-30	2010-06-30	2010-03-31	2009-12-31	2009-09-30	2009-06-30	2009-03-31	2008-12-31	2008-06-30	2007-12-31	2007-09-30	2007-06-30	2007-03-31	2006-12-31	2006-09-30	2006-06-30	2005-09-30	2005-06-30	2005-03-31	2004-09-30	2004-03-31	2003-12-31	2003-09-30	2003-06-30	2003-03-31	2002-09-30	2002-06-30	2002-03-31

revenues:
product revenue	47,167,000	49,007,000	39,436,000	47,506,000	28,209,000	780,000
royalties	60,000	29,000	167,000	117,000	62,000	102,000	304,000	53,500	164,000	29,000	21,000				123,000
total revenues	47,227,000	49,036,000	39,603,000	7,364,250	28,271,000	882,000																														5,108,000			35,363,000									636,000	130,000	1,254,000	251,000	220,000	462,000	1,505,000	1,098,000	546,000	1,001,000	918,000	605,000	494,000	183,000	444,000	2,605,000	198,000	4,687,000	1,130,000	889,000	916,000	4,066,000	723,000	786,000	673,000	4,671,000		101,000	248,000
costs and operating expenses:
cost of goods sold	1,043,000	1,190,000	1,206,000	783,000	456,000	17,000
research and development	21,070,000	21,736,000	15,078,000	23,433,000	20,153,000	30,779,000	29,373,000	32,911,000	29,426,000	35,490,000	27,219,000	28,210,000	24,603,000	20,606,000	22,099,000	24,150,000	18,527,000	21,937,000	21,113,000	16,228,000	13,613,000	10,845,000	10,802,000	24,923,000	11,109,000	10,134,000	5,906,000	5,081,000	2,707,000	3,204,000	2,440,000	2,523,000	2,637,000	2,499,000	3,374,000	4,319,000	4,575,000	5,033,000	4,050,000	4,812,000	4,987,000	5,994,000	5,151,000	5,211,000	5,338,000	4,807,000	7,999,000	11,684,000	12,777,000	15,107,000													42,050,000	11,614,000	15,011,000	12,326,000	14,098,000	13,189,000	5,688,000	10,703,000	9,326,000	12,183,000	6,824,000	6,473,000	8,900,000	5,718,000	4,900,000	4,864,000	7,772,000	6,964,000	6,346,000	8,146,000	10,164,000
selling, general and administrative	39,001,000	38,564,000	40,023,000	43,371,000	35,877,000	39,419,000
total costs and operating expenses	61,114,000
income from operations	-13,887,000	-12,454,000	-16,704,000	-20,050,000	-28,215,000	-69,333,000	-56,134,000	-54,289,000	-47,612,000	-51,951,000	-40,092,000	-41,951,000	-39,948,000	-27,976,000	-28,675,000	-30,982,000	-25,674,000	-28,889,000	-28,454,000	-23,266,000	-20,015,000	-16,762,000	-16,870,000	-30,008,000	-15,972,000	-15,224,000	-11,301,000	-9,589,000	-6,805,000	-7,242,000	-7,437,000	-7,786,000	-7,244,000						27,020,000											-18,918,000	-30,408,000	-19,936,000	-21,416,000	-24,356,000	-59,611,000	-18,203,000	-16,876,000	-16,477,000	-18,372,000	-16,400,000	-18,757,000	-16,705,000	-51,586,000	-15,458,000	-14,336,000	-15,335,000	-16,766,000	-16,402,000	-3,346,000	-12,094,000	-11,408,000	-12,921,000	-3,897,000	-10,363,000	-10,475,000	-52,011,000	-5,483,500	-5,237,000	-8,653,000	-8,044,000	-7,442,000	-9,488,000	-11,134,000
yoy	-50.78%	-82.04%	-70.24%	-63.07%	-40.74%	33.46%	40.01%	29.41%	19.18%	85.70%	39.82%	35.40%	55.60%	-3.16%	0.78%	33.16%	28.27%	72.35%	68.67%	-22.47%	25.31%	10.10%	49.28%	212.94%	134.71%	110.22%	51.96%	23.16%	-6.06%																					-22.33%	-48.99%	9.52%	26.90%	47.82%	224.47%	10.99%	-10.03%	-1.36%	-64.39%	6.09%	30.84%	8.93%	207.68%	-5.76%	328.45%	26.80%	46.97%	26.94%	-14.14%	16.70%	8.91%	-75.16%	-28.93%	97.88%	21.06%	546.58%	-26.32%	-44.80%	-22.28%
qoq	11.51%	-25.44%	-16.69%	-28.94%	-59.31%	23.51%	3.40%	14.02%	-8.35%	29.58%	-4.43%	5.01%	42.79%	-2.44%	-7.45%	20.67%	-11.13%	1.53%	22.30%	16.24%	19.41%	-0.64%	-43.78%	87.88%	4.91%	34.71%	17.85%	40.91%	-6.03%	-2.62%	-4.48%	7.48%																		-37.79%	52.53%	-6.91%	-12.07%	-59.14%	227.48%	7.86%	2.42%	-10.31%	12.02%	-12.57%	12.28%	-67.62%	233.72%	7.83%	-6.51%	-8.54%	2.22%	390.20%	-72.33%	6.01%	-11.71%	231.56%	-62.40%	-1.07%	-79.86%	848.50%	4.71%	-39.48%	7.57%	8.09%	-21.56%	-14.78%
operating margin %
interest income	4,264,000	4,656,000	5,152,000	5,159,000	4,877,000	5,332,000	4,239,000	4,596,000	4,965,000	4,738,000	3,853,000	1,235,000	852,000	330,000	112,000	106,000	112,000	136,000	173,000
interest expense	-8,644,000	-8,516,000	-8,200,000	-8,706,000	-3,046,000	-3,319,000	-3,433,000	-2,321,000	-2,066,000	-2,003,000	-1,922,000	-2,005,000	-1,817,000	-1,581,000	-1,479,000	-1,135,000	-1,058,000	-804,000	-743,000
other income and (expense)	-161,000	-61,000	-83,000	-47,000	-63,000	-63,000	-62,000	-16,000	-92,000	-11,000	39,000	229,000	-138,000	1,110,000	-56,000	-6,000	-77,000	-17,000	1,200,000
net income	-18,428,000	-16,375,000	-19,835,000	-25,352,000	-26,447,000	-67,383,000	-55,390,000	-51,973,000	-44,805,000	-49,227,000	-38,122,000	-42,635,000	-41,051,000	-28,117,000	-30,098,000	-32,017,000	-26,697,000	-29,574,000	-27,824,000	-23,787,000	-19,651,000	-15,824,000	-16,355,000	-29,070,000	-15,180,000	-14,239,000	-10,059,000	-7,300,000	-5,597,000	-6,934,000	-7,186,000	-7,429,000	-6,899,000	-6,405,000	-7,183,000	-3,576,000	-8,637,000	-8,842,000	27,185,000	-9,356,000	-9,315,000	-9,549,000	-8,734,000	-8,440,000	-8,254,000	-8,947,000	-11,897,000	-15,953,000	-18,326,000	-18,739,000	-31,854,000	-19,522,000	-21,088,000	-24,389,000	-59,362,000	-18,344,000	-17,031,000	-16,640,000	-18,391,000	-15,224,000	-19,758,000	-16,811,000	-48,457,000	-13,564,000	-11,045,000	-12,834,000	-13,985,000	1,167,000	-5,585,000	-9,837,000	-9,257,000	-11,862,000	-3,082,000	-9,688,000	-10,302,000	-51,683,000	-5,581,750	-5,107,000	-9,288,000	-7,932,000	-7,196,000	-9,008,000	-10,475,000
yoy	-30.32%	-75.70%	-64.19%	-51.22%	-40.97%	36.88%	45.30%	21.90%	9.14%	75.08%	26.66%	33.16%	53.77%	-4.93%	8.17%	34.60%	35.86%	86.89%	70.13%	-18.17%	29.45%	11.13%	62.59%	298.22%	171.22%	105.35%	39.98%	-1.74%	-18.87%	8.26%	0.04%	107.75%	-20.12%	-27.56%	-126.42%	-61.78%	-7.28%	-7.40%	-411.25%	10.85%	12.85%	6.73%	-26.59%	-47.09%	-54.96%	-52.25%	-62.65%	-18.28%	-13.10%	-23.17%	-46.34%	6.42%	23.82%	46.57%	222.78%	20.49%	-13.80%	-1.02%	-62.05%	12.24%	78.89%	30.99%	246.49%	-1262.30%	97.76%	30.47%	51.07%	-109.84%	81.21%	1.54%	-10.14%	-77.05%	-44.78%	89.70%	10.92%	551.58%	-22.43%	-43.31%	-11.33%
qoq	12.54%	-17.44%	-21.76%	-4.14%	-60.75%	21.65%	6.57%	16.00%	-8.98%	29.13%	-10.59%	3.86%	46.00%	-6.58%	-5.99%	19.93%	-9.73%	6.29%	16.97%	21.05%	24.18%	-3.25%	-43.74%	91.50%	6.61%	41.55%	37.79%	30.43%	-19.28%	-3.51%	-3.27%	7.68%	7.71%	-10.83%	100.87%	-58.60%	-2.32%	-132.53%	-390.56%	0.44%	-2.45%	9.33%	3.48%	2.25%	-7.75%	-24.80%	-25.42%	-12.95%	-2.20%	-41.17%	63.17%	-7.43%	-13.53%	-58.91%	223.60%	7.71%	2.35%	-9.52%	20.80%	-22.95%	17.53%	-65.31%	257.25%	22.81%	-13.94%	-8.23%	-1298.37%	-120.90%	-43.22%	6.27%	-21.96%	284.88%	-68.19%	-5.96%	-80.07%	825.93%	9.30%	-45.02%	17.10%	10.23%	-20.12%	-14.00%
net income margin %
basic and diluted net income per share	-0.03	-0.02	-0.03	-0.04	-0.04	-0.1	-0.09	-0.09	-0.08	-0.09	-0.07	-0.11	-0.1	-0.07	-0.09	-0.09	-0.08	-0.09	-0.09	-0.08	-0.06	-0.06	-0.08	-0.15	-0.08	-0.08	-0.05	-0.04	-0.03	-0.04	-0.04	-0.033	-0.04	-0.04	-0.05		-0.05	-0.06		-0.06	-0.06	-0.06	-0.06	-0.06	-0.06	-0.07	-0.09	-0.13	-0.14	-0.15	-0.13	-0.16	-0.17	-0.2				-0.18				-0.2							-0.108	-0.15	-0.14	-0.21	-0.06	-0.18	-0.23	-1.28	-0.19	-0.15	-0.32	-0.32	-0.29	-0.37	-0.43
shares used in computing basic and diluted net income per share	667,101,756	666,170,358	665,905,469	6,099,635	662,158,182	653,904,978	603,493,451	8,199,828	579,508,305	547,280,946	544,459,004	125,797	405,237,474	403,868,713	332,066,889	1,079,051	328,934,491	327,026,907	323,638,696	15,899,486	318,799,174	246,966,143	200,222,092	2,792,690	189,123,647	186,556,082	186,393,128	3,317,243	184,301,986	174,475,244	160,525,947	39,796,713.25	159,216,642	159,182,367	159,161,550		158,998,931	158,896,038		158,066,910	157,547,568	156,843,989	156,706,196	143,465,818	128,293,074	128,162,993	127,982,931	127,236,993	126,891,909	126,372,846				123,098,728				95,012,100				84,160,889
total operating expenses		61,490,000	56,307,000	67,587,000	56,486,000	70,215,000	56,438,000	54,312,000	47,776,000	51,980,000	40,113,000	42,054,000	40,245,000	28,049,000	28,798,000	32,022,000	25,783,000	28,996,000	28,591,000	23,316,000	20,123,000	16,805,000	16,922,000	30,179,000	16,103,000	15,325,000	11,358,000	9,964,000	6,970,000	7,450,000	7,755,000	7,977,000	7,407,000	6,905,000	8,031,000	8,985,000	9,122,000	9,826,000	8,343,000	9,730,000	9,993,000	10,067,000	9,004,000	9,205,000	8,914,000	9,077,000	12,750,000	16,513,000	18,609,000	20,172,000	30,659,000	20,156,000	21,878,000	25,861,000	60,709,000	18,749,000	17,877,000	17,395,000	18,977,000	16,894,000	18,940,000	17,149,000	54,191,000	15,656,000	19,023,000	16,465,000	17,655,000	17,318,000	7,412,000	12,817,000	12,194,000	13,594,000	8,568,000	10,422,000	10,576,000	52,259,000
operating expenses:
general and administrative							27,065,000	21,401,000	18,350,000	16,490,000	12,894,000	13,844,000	15,642,000	7,443,000	6,699,000	7,872,000	7,256,000	7,059,000	7,478,000	7,088,000	6,510,000	5,960,000	6,120,000	5,256,000	4,994,000	5,191,000	5,452,000	4,883,000	4,263,000	4,246,000	5,315,000	5,454,000	4,770,000	4,406,000	4,657,000	4,666,000	4,547,000	4,793,000	4,334,000	3,977,000	4,600,000	4,073,000	3,853,000	3,994,000	3,460,000	3,432,000	4,751,000	4,829,000	5,832,000	5,065,000	5,538,000	3,811,000	5,334,000	9,106,000	4,684,000	5,021,000	4,488,000	3,850,000	3,638,000	3,499,000	3,828,000	3,378,000	12,141,000	4,042,000	4,012,000	4,139,000	3,557,000	4,129,000	1,724,000	2,114,000	2,868,000	1,411,000	1,744,000	3,949,000	1,676,000	1,391,000	838,250	845,000	1,166,000	1,342,000	1,314,000	1,453,000	1,596,000
license fees and royalties												103,000	297,000	73,000		1,040,000	109,000	107,000	137,000	50,000	108,000	43,000	52,000	171,000	131,000	101,000	57,000	375,000	165,000	208,000	318,000	191,000	163,000	174,000	537,000	5,108,000	211,000	749,000	363,000	251,000	537,000	160,000	341,000	474,000	181,000	112,000	765,000	636,000	130,000	1,254,000	251,000	220,000	312,000	1,355,000	453,000	343,000	776,000	693,000					2,398,000	111,000	4,612,000	1,130,000	585,000	623,000	4,141,000	524,000	675,000	606,000	4,620,000	59,000	101,000	248,000	236,750	472,000	249,000	226,000	200,000	96,000	111,000
change in fair value of equity investment																				-49,000	-118,000	422,000	-195,000		-195,000	-98,000	98,000	-271,000	205,000	-350,000	-125,000
interest and other income																				433,250	504,000	475,000	754,000	925,000	1,021,000	1,113,000	1,162,000	1,120,000	1,060,000	717,000	394,000	375,000	363,000	346,000	332,000	322,000	293,000	256,000	187,000	145,000	149,000	91,000	99,000	83,000	699,000	56,000	81,000	140,000	165,000	176,000	204,000	237,000	287,000	296,000	1,426,000	223,000	194,000	202,000	246,000	240,000	363,000	525,000	4,119,000	1,423,000	2,384,000	2,772,000	2,843,000	2,792,000	-1,706,000	2,283,000	2,189,000	1,105,000	998,000	847,000	348,000	498,000	239,250	287,000	394,000	276,000	434,000	665,000	871,000
other income																						41,000	-44,000	13,000	-34,000	-30,000	-18,000	-20,000	-57,000	-59,000
collaboration revenue																																							35,000,000
restructuring charges																																								941,000	406,000				116,000	838,000
unrealized gain on derivatives																																									16,000	289,000		224,000			25,000		8,000		142,500	291,000	240,000		33,250	-97,000	172,000	58,000	-71,750	966,000	-1,330,000		123,750	495,000	931,000	-247,000	-36,000	14,805,000
net income per share																																																											-0.148	-0.17
basic																																				-0.02			0.17
diluted																																				-0.02			0.17
shares used in computing net income per share:
basic																																				159,140,254			158,151,747
diluted																																				159,140,254			162,669,681
unrealized loss on derivatives
revenues from collaborative agreements																																																					150,000	150,000	163,250	203,000	225,000	225,000					207,000	87,000	75,000			293,000	-75,000	199,000	111,000	67,000	51,000				18,000		36,000	36,000	18,000	15,000	515,000
losses recognized under equity method investment																																																					-168,000	-335,000	-1,212,000	-243,000	-496,000	-396,000	-164,000			-656,000
unrealized gain on fair value of derivatives																																																		26,000				39,000								77,000
research and development (including amounts
for related parties: three months - 2011-none;
2010-53; nine months – 2011-none; 2010-697)																																																			12,411,000	16,345,000
shares used in computing basic and diluted net income
per share																																																			31,064,924.5	125,101,177	124,579,190
research and development (including amounts for
related parties: three months - 2011-none; 2010-
317; six months – 2011-none; 2010-644)																																																					16,544,000
for related parties: 2011-none, 2010-327)																																																						16,755,000
related parties: three months – 2010-53; 2009-
397; nine months – 2010-697; 2009-1,328)																																																							10,165,500	13,728,000
deemed dividend on derivatives																																																													-190,000				-5,420,000			-3,661,000
net income applicable to common stockholders																																																							-59,362,000	-18,344,000	-17,031,000		-12,995,750	-15,224,000	-19,948,000		-3,391,000	-13,564,000	-7,328,250	-12,834,000	-13,985,000	-2,494,000
basic and diluted net income per share applicable to
common stockholders																																																							97,601,520.54	-0.19	-0.18
per share applicable to common stockholders																																																							24,100,069	97,476,668	96,712,059
related parties: three months - 2010-317; 2009-
502; six months – 2010-644; 2009-931)																																																									13,389,000
for related parties: 2010-327, 2009-429)																																																										13,545,000
revenues from collaborative
agreements (including amounts from related
parties: three months - 2009-none, 2008-20;
nine months - 2009-none, 2008-79)																																																											56,250	225,000
license fees and royalties (including amounts
from related parties: three months -
2009-none, 2008-none; nine months -
2009-none, 2008-1,500)																																																											224,000	269,000
research and development (including
amounts for related parties:
three months - 2009-397, 2008-184;
nine months - 2009-1,328, 2008-502)																																																											10,569,500	13,395,000
basic and diluted net income per share applicable
to common stockholders
net income per share																																																											-0.148	-0.17
shares used in computing net income per share
applicable to common stockholders																																																											708,196	89,402,642	88,547,553
parties: three months - 2009-none; 2008-
33; six months - 2009-none; 2008-59)
from related parties: three months - 2009-none;
2008-none; six months - 2009-none; 2008-
1,500)																																																													183,000
amounts for related parties: three months -
2009-502; 2008-169; six months - 2009-
931; 2008-318)																																																													15,112,000
losses recognized under equity method
investment
stockholders																																																													-0.23
revenues from collaborative agreements (including amounts from
related parties: 2009-none, 2008-26)
license fees and royalties (including amounts from related
parties: 2009-none, 2008-1,500)																																																														444,000
research and development (including amounts for related
parties: 2009-429, 2008-149)																																																														13,771,000
basic and diluted net income per share applicable to common stockholders																																																															-0.043	-0.17	-0.1	-0.17	-0.19	-0.03
shares used in computing basic and diluted net income per share applicable to common stockholders																																																															19,535,544	78,142,176	18,433,289.75	75,324,687	74,077,733	71,797,056
equity in losses in joint venture
weighted-average shares used for eps calculation																																																																						66,166,827	65,932,548	57,225,184	55,301,745	54,175,184		40,449,815		33,189,213	29,452,031	24,935,574	24,737,635	24,674,456	24,490,391
acquired in-process research technology																																																																												45,150,000
equity in losses of joint venture																																																																									-12,000
acquired in-process research
technology
debenture conversion expense																																																																													-194,750		-779,000
computing basic and diluted net
loss per share																																																																											45,442,854

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