Quarterly
Annual
| Unit: USD | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2017-12-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | 2016-09-30 | 2016-06-30 | 2016-03-31 | 2015-09-30 | 2015-06-30 | 2015-03-31 | 2014-09-30 | 2014-06-30 | 2014-03-31 | 2013-09-30 | 2013-06-30 | 2013-03-31 | 2012-09-30 | 2012-06-30 | 2012-03-31 | 2011-12-31 | 2011-09-30 | 2011-06-30 | 2011-03-31 | 2010-12-31 | 2010-09-30 | 2010-06-30 | 2010-03-31 | 2009-12-31 | 2008-09-30 | 2008-06-30 | 2007-09-30 | 2007-06-30 | 2007-03-31 | 2006-09-30 | 2006-06-30 | 2005-09-30 | 2005-06-30 | 2005-03-31 | 2004-12-31 | 2004-09-30 | 2004-03-31 | 2003-09-30 | 2003-06-30 | 2003-03-31 | 2002-09-30 | 2002-06-30 | 2002-03-31 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
assets | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current assets: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents | 78,117,000 | 77,734,000 | 83,745,000 | 79,016,000 | 60,344,000 | 116,945,000 | 189,761,000 | 70,023,000 | 30,709,000 | 56,903,000 | 112,777,000 | 56,845,000 | 61,103,000 | 76,057,000 | 31,325,000 | 34,871,000 | 29,036,000 | 57,282,000 | 31,537,000 | 9,925,000 | 44,956,000 | 22,865,000 | 20,294,000 | 13,644,000 | 20,751,000 | 17,710,000 | 6,800,000 | 10,575,000 | 12,729,000 | 19,127,000 | 7,912,000 | 16,335,000 | 9,904,000 | 6,606,000 | 14,861,000 | 5,883,000 | 8,199,000 | 12,802,000 | 16,823,000 | 15,798,000 | 10,182,000 | 7,600,000 | 9,520,000 | 11,324,000 | 9,591,000 | 8,834,000 | 15,505,000 | 16,008,000 | 14,123,000 | 19,031,000 | 16,105,000 | 33,975,000 | 32,019,000 | 35,412,000 | 45,972,000 | 34,490,000 | 37,315,000 | 35,900,000 | 34,601,000 | 121,807,000 | 127,080,000 | 152,767,000 | 126,943,000 | 145,722,000 | 104,556,000 | 68,875,000 | 119,303,000 | 21,609,000 | 7,530,000 | 9,846,000 | 10,185,000 | 6,529,000 | 8,042,000 | 10,956,000 | 7,089,000 | 15,428,000 | 28,245,000 | 19,609,000 |
restricted cash | 1,876,000 | 1,870,000 | 1,865,000 | 1,860,000 | 1,854,000 | 1,123,000 | 1,119,000 | 1,115,000 | 536,000 | 535,000 | 365,000 | 364,000 | 364,000 | 364,000 | 364,000 | 364,000 | 363,000 | 363,000 | 363,000 | 363,000 | 363,000 | 363,000 | 270,000 | 270,000 | 270,000 | 270,000 | 270,000 | 269,000 | 269,000 | 269,000 | 268,000 | 268,000 | 268,000 | 268,000 | 268,000 | 268,000 | 267,000 | 267,000 | 266,000 | 266,000 | 266,000 | 265,000 | 795,000 | 795,000 | 795,000 | 795,000 | 794,000 | 794,000 | 794,000 | 793,000 | 793,000 | 793,000 | 793,000 | 792,000 | 792,000 | 792,000 | 792,000 | 791,000 | 791,000 | 832,000 | 1,082,000 | 530,000 | 530,000 | 530,000 | 530,000 | 530,000 | 905,000 | 905,000 | 530,000 | 530,000 | 530,000 | 530,000 | 530,000 | 530,000 | 530,000 | 530,000 | 530,000 | 530,000 |
marketable securities | 302,415,000 | 310,247,000 | 313,132,000 | 327,550,000 | 279,430,000 | 245,789,000 | 253,288,000 | 263,676,000 | 282,818,000 | 314,475,000 | 267,964,000 | 115,901,000 | 133,684,000 | 143,230,000 | 135,345,000 | 148,851,000 | 147,084,000 | 140,959,000 | 179,490,000 | 186,350,000 | 182,667,000 | 195,881,000 | 111,822,000 | 125,681,000 | 117,860,000 | 134,778,000 | 145,180,000 | 152,714,000 | 153,622,000 | 141,800,000 | 81,868,000 | 78,351,000 | 86,991,000 | 88,239,000 | 84,432,000 | 102,655,000 | 102,402,000 | 96,846,000 | 102,857,000 | 122,214,000 | 135,655,000 | 56,617,000 | 61,966,000 | 63,534,000 | 52,537,000 | 58,571,000 | 54,875,000 | 90,011,000 | 75,504,000 | 69,493,000 | 112,276,000 | 79,536,000 | 104,525,000 | 116,955,000 | 110,118,000 | 80,015,000 | 92,673,000 | |||||||||||||||||||||
accounts receivable | 35,361,000 | 36,608,000 | 31,166,000 | 35,946,000 | 28,007,000 | 874,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
interest and other receivables | 2,295,000 | 2,755,000 | 2,817,000 | 2,853,000 | 2,082,000 | 2,252,000 | 1,629,000 | 1,655,000 | 14,754,000 | 1,187,000 | 1,596,000 | 3,144,000 | 22,223,000 | 4,254,000 | 5,239,000 | 1,763,000 | 610,000 | 714,000 | 759,000 | 722,000 | 989,000 | 822,000 | 701,000 | 802,000 | 795,000 | 838,000 | 976,000 | 1,168,000 | 778,000 | 773,000 | 569,000 | 436,000 | 514,000 | 457,000 | 597,000 | 5,404,000 | 586,000 | 624,000 | 1,238,000 | 1,505,000 | 1,190,000 | 787,000 | 1,256,000 | 1,439,000 | 555,000 | 480,000 | 921,000 | 842,000 | 932,000 | 866,000 | 1,398,000 | 1,569,000 | 1,630,000 | 1,676,000 | 1,799,000 | 1,047,000 | 1,390,000 | 1,359,000 | 1,318,000 | 186,000 | 305,000 | 1,105,000 | 1,259,000 | 856,000 | 1,488,000 | 1,883,000 | 1,367,000 | 1,674,000 | 1,638,000 | 1,550,000 | 960,000 | 5,477,000 | 681,000 | 665,000 | 354,000 | 1,162,000 | 803,000 | 1,016,000 |
inventory | 95,422,000 | 69,125,000 | 56,222,000 | 38,714,000 | 20,283,000 | 774,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
prepaid expenses and other current assets | 6,856,000 | 7,256,000 | 6,822,000 | 6,057,000 | 5,551,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total current assets | 522,342,000 | 505,595,000 | 495,769,000 | 490,992,000 | 398,057,000 | 373,308,000 | 451,509,000 | 341,348,000 | 335,085,000 | 377,279,000 | 387,023,000 | 180,246,000 | 222,070,000 | 227,375,000 | 175,924,000 | 187,206,000 | 179,355,000 | 201,762,000 | 215,264,000 | 199,857,000 | 231,861,000 | 220,743,000 | 134,155,000 | 141,608,000 | 142,121,000 | 154,762,000 | 155,949,000 | 166,058,000 | 168,874,000 | 162,270,000 | 91,129,000 | 95,970,000 | 98,563,000 | 102,066,000 | 106,563,000 | 115,056,000 | 111,702,000 | 110,955,000 | 122,015,000 | 140,198,000 | 147,897,000 | 128,192,000 | 142,592,000 | 147,676,000 | 68,402,000 | 72,431,000 | 81,576,000 | 103,046,000 | 120,845,000 | 122,522,000 | 125,625,000 | 147,304,000 | 157,194,000 | 170,203,000 | 195,017,000 | 137,474,000 | 130,948,000 | 133,234,000 | 117,779,000 | 179,080,000 | 192,917,000 | 212,000 | 222,631,000 | 224,955,000 | 178,141,000 | 186,374,000 | 204,030,000 | 132,172,000 | 129,477,000 | 124,777,000 | 95,128,000 | 109,366,000 | ||||||
noncurrent marketable securities | 39,063,000 | 42,743,000 | 58,795,000 | 94,519,000 | 37,312,000 | 66,505,000 | 20,782,000 | 43,298,000 | 67,821,000 | 28,281,000 | 28,100,000 | 10,945,000 | 28,651,000 | 39,362,000 | 40,521,000 | 33,289,000 | 63,387,000 | 45,768,000 | 46,223,000 | 1,029,000 | 19,651,000 | 20,404,000 | 9,497,000 | 17,871,000 | 18,582,000 | 18,143,000 | 20,250,000 | 13,184,000 | 14,241,000 | 15,560,000 | 22,076,000 | 22,126,000 | 21,005,000 | 25,523,000 | 31,976,000 | 31,821,000 | 18,734,000 | 17,739,000 | ||||||||||||||||||||||||||||||||||||||||
property and equipment | 973,000 | 1,189,000 | 1,147,000 | 1,310,000 | 1,595,000 | 1,626,000 | 1,681,000 | 1,177,000 | 1,231,000 | 1,147,000 | 1,066,000 | 793,000 | 733,000 | 641,000 | 643,000 | 650,000 | 608,000 | 590,000 | 620,000 | 658,000 | 689,000 | 734,000 | 749,000 | 408,000 | 348,000 | 100,000 | 89,000 | 59,000 | 66,000 | 71,000 | 86,000 | 102,000 | 121,000 | 140,000 | 158,000 | 170,000 | 191,000 | 212,000 | 183,000 | 151,000 | 171,000 | 63,000 | 60,000 | 77,000 | 116,000 | 566,000 | 866,000 | 1,431,000 | 1,240,000 | 1,074,000 | 1,241,000 | 2,247,000 | 2,514,000 | 2,794,000 | 3,088,000 | 3,217,000 | 3,499,000 | 3,934,000 | 3,938,000 | 4,240,000 | 4,092,000 | 3,709,000 | 3,868,000 | 3,064,000 | 2,526,000 | 2,623,000 | 2,326,000 | 2,087,000 | 1,975,000 | 2,089,000 | 2,173,000 | 1,558,000 | 1,809,000 | 1,983,000 | 2,167,000 | 2,788,000 | 3,166,000 | 3,521,000 |
operating leases, right-of-use assets | 2,339,000 | 2,523,000 | 2,704,000 | 2,881,000 | 3,055,000 | 3,225,000 | 3,392,000 | 3,556,000 | 3,683,000 | 3,841,000 | 3,995,000 | 4,147,000 | 4,296,000 | 4,442,000 | 4,586,000 | 4,727,000 | 4,892,000 | 5,029,000 | 5,163,000 | 5,295,000 | 5,425,000 | 5,492,000 | 5,827,000 | 2,497,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
deposits and other assets | 2,665,000 | 3,148,000 | 4,035,000 | 4,079,000 | 4,931,000 | 4,735,000 | 4,710,000 | 4,697,000 | 5,197,000 | 4,748,000 | 4,693,000 | 5,389,000 | 5,507,000 | 5,703,000 | 6,323,000 | 4,800,000 | 4,880,000 | 4,273,000 | 4,272,000 | 1,531,000 | 2,050,000 | 1,622,000 | 1,129,000 | 1,353,000 | 191,000 | 191,000 | 191,000 | 195,000 | 414,000 | 410,000 | 825,000 | 825,000 | 879,000 | 1,048,000 | 932,000 | 920,000 | 230,000 | 210,000 | 190,000 | 284,000 | 212,000 | 296,000 | 1,969,000 | 702,000 | 693,000 | 693,000 | 594,000 | 596,000 | 640,000 | 520,000 | 170,000 | 170,000 | 175,000 | 202,000 | 231,000 | 227,000 | 227,000 | 240,000 | 254,000 | 340,000 | 265,000 | |||||||||||||||||
liabilities and stockholders' equity | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current liabilities: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts payable | 11,111,000 | 8,226,000 | 8,032,000 | 8,595,000 | 13,734,000 | 5,620,000 | 9,992,000 | 6,161,000 | 13,684,000 | 7,673,000 | 3,383,000 | 10,190,000 | 8,183,000 | 4,521,000 | 6,245,000 | 6,687,000 | 4,714,000 | 3,758,000 | 4,459,000 | 6,919,000 | 3,739,000 | 3,797,000 | 3,376,000 | 1,181,000 | 2,031,000 | 1,210,000 | 913,000 | 982,000 | 190,000 | 458,000 | 502,000 | 503,000 | 261,000 | 205,000 | 308,000 | 271,000 | 235,000 | 396,000 | 574,000 | 957,000 | 1,180,000 | 2,365,000 | 1,223,000 | 1,520,000 | 1,547,000 | 1,176,000 | 1,669,000 | 3,014,000 | 3,429,000 | 2,666,000 | 2,980,000 | 4,006,000 | 3,471,000 | 3,343,000 | 3,462,000 | 1,958,000 | 1,715,000 | 1,807,000 | 2,176,000 | 2,108,000 | 2,443,000 | 1,990,000 | 4,118,000 | 3,342,000 | 1,435,000 | 1,572,000 | 3,067,000 | 1,848,000 | 1,388,000 | 2,535,000 | 1,667,000 | 798,000 | 1,212,000 | 1,259,000 | 1,797,000 | 847,000 | 861,000 | 785,000 |
accrued compensation and benefits | 16,388,000 | 11,336,000 | 9,603,000 | 22,808,000 | 15,180,000 | 11,382,000 | 6,794,000 | 13,759,000 | 10,837,000 | 8,232,000 | 4,906,000 | 11,534,000 | 7,637,000 | 5,613,000 | 3,682,000 | 8,099,000 | 6,615,000 | 5,216,000 | 3,446,000 | 8,218,000 | 5,554,000 | 4,204,000 | 2,674,000 | 4,830,000 | 3,443,000 | 2,756,000 | 1,661,000 | 2,642,000 | 1,833,000 | 1,531,000 | 1,100,000 | 3,385,000 | 2,651,000 | 2,056,000 | 1,489,000 | 2,205,000 | 2,311,000 | 1,619,000 | 2,248,000 | 1,731,000 | 2,135,000 | 2,685,000 | 2,186,000 | 1,556,000 | 2,886,000 | 2,046,000 | 1,664,000 | 3,907,000 | 3,421,000 | 1,774,000 | 3,029,000 | |||||||||||||||||||||||||||
operating lease liabilities | 994,000 | 987,000 | 981,000 | 974,000 | 968,000 | 961,000 | 955,000 | 949,000 | 943,000 | 786,000 | 931,000 | 925,000 | 919,000 | 913,000 | 907,000 | 901,000 | 895,000 | 889,000 | 883,000 | 878,000 | 872,000 | 856,000 | 828,000 | 354,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
liability related to sale of future royalties | 19,291,000 | 17,440,000 | 15,532,000 | 20,372,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accrued liabilities | 39,928,000 | 26,294,000 | 28,886,000 | 35,549,000 | 36,489,000 | 38,660,000 | 33,891,000 | 40,308,000 | 41,862,000 | 45,036,000 | 34,691,000 | 33,100,000 | 53,111,000 | 30,670,000 | 35,796,000 | 29,834,000 | 26,246,000 | 27,150,000 | 19,764,000 | 14,925,000 | 13,989,000 | 10,285,000 | 10,037,000 | 7,528,000 | 4,831,000 | 3,237,000 | 1,037,000 | 1,317,000 | 926,000 | 1,112,000 | 856,000 | 1,054,000 | 1,432,000 | 1,126,000 | 1,071,000 | 727,000 | 933,000 | 1,375,000 | 2,018,000 | 1,057,000 | 1,286,000 | 1,985,000 | 1,358,000 | 2,591,000 | 4,171,000 | 4,378,000 | 4,379,000 | 3,641,000 | 3,005,000 | 3,066,000 | 3,536,000 | 2,644,000 | 1,509,000 | 1,485,000 | 1,925,000 | 2,419,000 | 3,721,000 | 3,398,000 | 2,365,000 | 1,367,000 | 1,160,000 | 1,008,000 | 862,000 | 580,000 | 822,000 | 677,000 | 648,000 | 906,000 | 1,082,000 | 905,000 | 1,762,000 | 1,529,000 | 1,434,000 | |||||
total current liabilities | 87,712,000 | 64,283,000 | 63,034,000 | 88,298,000 | 137,933,000 | 103,540,000 | 123,158,000 | 108,070,000 | 89,386,000 | 72,569,000 | 43,911,000 | 76,694,000 | 82,809,000 | 46,879,000 | 46,630,000 | 45,521,000 | 38,470,000 | 37,013,000 | 28,552,000 | 30,940,000 | 24,154,000 | 19,142,000 | 16,916,000 | 28,162,000 | 11,862,000 | 9,181,000 | 6,253,000 | 7,551,000 | 4,467,000 | 4,905,000 | 4,385,000 | 6,516,000 | 5,970,000 | 11,274,000 | 11,596,000 | 7,319,000 | 7,111,000 | 6,658,000 | 6,125,000 | 40,727,000 | 40,632,000 | 7,069,000 | 4,756,000 | 4,516,000 | 6,837,000 | 5,004,000 | 6,793,000 | 11,256,000 | 11,992,000 | 10,274,000 | 13,444,000 | 10,003,000 | 9,270,000 | 9,363,000 | 40,849,000 | 7,625,000 | 6,813,000 | 6,805,000 | 7,455,000 | 8,548,000 | 8,579,000 | 11,459,000 | 13,436,000 | 10,916,000 | 5,691,000 | 5,551,000 | 8,767,000 | 5,613,000 | 5,142,000 | 84,581,852,426,982,000 | 7,635,000 | 7,040,000 | ||||||
noncurrent operating lease liabilities | 1,658,000 | 1,865,000 | 2,069,000 | 2,266,000 | 2,458,000 | 2,645,000 | 2,829,000 | 3,006,000 | 3,179,000 | 3,498,000 | 3,512,000 | 3,671,000 | 3,826,000 | 3,977,000 | 4,125,000 | 4,267,000 | 4,405,000 | 4,540,000 | 4,672,000 | 4,799,000 | 4,922,000 | 4,991,000 | 5,159,000 | 2,200,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
noncurrent liability related to sale of future royalties | 110,041,000 | 110,528,000 | 110,381,000 | 104,421,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
noncurrent debt | 119,264,000 | 118,991,000 | 118,728,000 | 118,476,000 | 12,275,000 | 36,519,000 | 11,219,000 | 35,051,000 | 29,838,000 | 40,802,000 | 51,399,000 | 30,212,000 | 37,799,000 | 45,258,000 | 50,179,000 | 49,830,000 | 34,669,000 | 34,416,000 | 24,222,000 | 24,042,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
commitments and contingencies | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stockholders' equity: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
common stock | 638,000 | 638,000 | 637,000 | 606,000 | 603,000 | 601,000 | 591,000 | 545,000 | 542,000 | 522,000 | 509,000 | 390,000 | 382,000 | 378,000 | 324,000 | 324,000 | 321,000 | 321,000 | 318,000 | 310,000 | 310,000 | 310,000 | 200,000 | 200,000 | 193,000 | 187,000 | 186,000 | 186,000 | 186,000 | 183,000 | 161,000 | 160,000 | 159,000 | 159,000 | 159,000 | 159,000 | 159,000 | 159,000 | 158,000 | 158,000 | 158,000 | 157,000 | 157,000 | 157,000 | 129,000 | 130,000 | 130,000 | 131,000 | 131,000 | 132,000 | 132,000 | 131,000 | 129,000 | 103,000 | 99,000 | 97,000 | 79,000 | 79,000 | 75,000 | 75,000 | 73,000 | 66,000 | 66,000 | 65,000 | 55,000 | 54,000 | 45,000 | 45,000 | 33,000 | 33,000 | 25,000 | 25,000 | 25,000 | 24,000 | ||||
additional paid-in capital | 2,074,640,000 | 2,067,327,000 | 2,059,473,000 | 2,051,794,000 | 2,037,653,000 | 2,027,173,000 | 1,997,709,000 | 1,844,988,000 | 1,836,818,000 | 1,799,841,000 | 1,777,470,000 | 1,493,469,000 | 1,479,417,000 | 1,472,407,000 | 1,399,713,000 | 1,398,006,000 | 1,390,940,000 | 1,388,909,000 | 1,384,262,000 | 1,366,188,000 | 1,364,194,000 | 1,362,373,000 | 1,217,105,000 | 1,214,835,000 | 1,202,902,000 | 1,192,338,000 | 1,190,651,000 | 1,189,194,000 | 1,187,557,000 | 1,176,823,000 | 1,092,931,000 | 1,089,684,000 | 1,086,578,000 | 1,084,440,000 | 1,082,270,000 | 1,078,170,000 | 1,075,922,000 | 1,073,515,000 | 1,067,712,000 | 1,065,352,000 | 1,062,782,000 | 1,056,543,000 | 1,054,383,000 | 1,052,028,000 | 945,241,000 | 943,518,000 | 942,192,000 | 938,080,000 | 936,719,000 | 935,069,000 | 932,066,000 | 928,898,000 | 925,098,000 | 920,706,000 | 881,358,000 | 783,865,000 | 775,432,000 | 767,831,000 | 750,158,000 | 668,500,000 | 664,104,000 | 633,508,000 | 628,703,000 | 619,703,000 | 573,868,000 | 572,881,000 | 560,810,000 | 481,565,000 | 476,554,000 | 458,965,000 | 418,578,000 | 414,312,000 | ||||||
accumulated deficit | -1,826,979,000 | -1,808,551,000 | -1,792,176,000 | -1,772,341,000 | -1,746,989,000 | -1,720,542,000 | -1,653,159,000 | -1,597,769,000 | -1,545,796,000 | -1,500,991,000 | -1,451,764,000 | -1,413,642,000 | -1,371,007,000 | -1,329,956,000 | -1,301,839,000 | -1,271,741,000 | -1,239,724,000 | -1,213,027,000 | -1,183,453,000 | -1,155,629,000 | -1,131,842,000 | -1,112,191,000 | -1,096,367,000 | -1,080,012,000 | -1,050,942,000 | -1,035,762,000 | -1,021,523,000 | -1,011,464,000 | -1,004,164,000 | -998,567,000 | -991,633,000 | -985,840,000 | -978,411,000 | -804,242,000 | -785,503,000 | -753,649,000 | -734,127,000 | -713,039,000 | -688,650,000 | -629,282,000 | -610,938,000 | -593,907,000 | -577,267,000 | -489,261,000 | -472,110,000 | -428,407,000 | -415,573,000 | -401,588,000 | -397,703,000 | -387,866,000 | -360,703,000 | -348,841,000 | -345,759,000 | -336,071,000 | -326,596,000 | -307,349,000 | -248,110,000 | -243,003,000 | -233,715,000 | -218,554,000 | -211,358,000 | -202,350,000 | ||||||||||||||||
accumulated other comprehensive gain | 408,000 | 261,000 | -173,000 | 16,000 | 3,000 | 35,000 | 78,000 | 170,000 | 189,000 | -124,000 | 132,000 | 239,000 | 281,000 | 99,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total stockholders' equity | 248,707,000 | 259,531,000 | 268,238,000 | 280,320,000 | 292,284,000 | 306,695,000 | 344,868,000 | 247,949,000 | 290,614,000 | 298,427,000 | 326,055,000 | 79,998,000 | 108,172,000 | 142,047,000 | 97,487,000 | 126,416,000 | 151,553,000 | 176,206,000 | 201,162,000 | 210,947,000 | 232,832,000 | 250,681,000 | 120,814,000 | 135,155,000 | 152,392,000 | 157,044,000 | 169,413,000 | 177,733,000 | 183,467,000 | 178,362,000 | 101,128,000 | 103,797,000 | 108,274,000 | |||||||||||||||||||||||||||||||||||||||||||||
accumulated other comprehensive loss | 117,000 | 304,000 | 1,017,000 | -537,000 | -273,000 | 185,000 | -950,000 | -945,000 | -160,000 | -219,000 | -620,000 | -782,000 | -711,000 | -183,000 | -112,000 | -77,000 | -331,000 | -207,000 | -52,000 | -46,000 | -91,000 | -174,000 | -42,000 | -139,000 | -96,000 | -16,000 | -271,000 | -276,000 | -37,000 | -156,000 | -215,000 | -318,000 | -466,000 | -711,000 | -731,000 | -902,000 | -623,000 | -716,000 | -357,000 | -470,000 | -475,000 | -441,000 | ||||||||||||||||||||||||||||||||||||
debt | 71,562,000 | 46,917,000 | 71,526,000 | 46,893,000 | 22,060,000 | 10,842,000 | 20,945,000 | 12,959,000 | 5,162,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
prepaid and other current assets | 5,053,000 | 5,712,000 | 4,879,000 | 6,268,000 | 4,179,000 | 4,321,000 | 3,992,000 | 4,696,000 | 3,470,000 | 3,651,000 | 1,357,000 | 2,262,000 | 2,444,000 | 3,115,000 | 2,497,000 | 2,886,000 | 812,000 | 1,068,000 | 1,211,000 | 2,445,000 | 1,166,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total liabilities | 313,461,000 | 146,127,000 | 110,577,000 | 99,618,000 | 59,781,000 | 52,961,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.001 par value; 3,000,000 shares authorized; no shares issued and outstanding at december 31, 2024 and 2023 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.001 par value; 3,000,000 shares authorized; no shares issued and outstanding at december 31, 2023 and 2022 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.001 par value; 3,000,000 shares authorized; no shares issued and outstanding at december 31, 2022 and 2021 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.001 par value; 3,000,000 shares authorized; no shares issued and outstanding at december 31, 2021 and 2020 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
amount due to janssen biotech, inc. | 1,000 | 14,269,000 | 1,208,000 | 1,576,000 | 2,071,000 | 2,610,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.001 par value; 3,000,000 shares authorized; no shares issued and outstanding at december 31, 2020 and 2019 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
term loan | 23,885,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.001 par value; 3,000,000 shares authorized; no shares issued and outstanding at december 31, 2019 and 2018 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
operating lease, right-of-use asset | 349,000 | 402,000 | 571,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other assets | 1,032,000 | 1,464,000 | 1,186,000 | 585,000 | 851,000 | 676,000 | 1,114,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
operating lease liability | 349,000 | 402,000 | 571,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
prepaid assets | 2,723,000 | 1,332,000 | 1,476,000 | 301,000 | 512,000 | 580,000 | 886,000 | 496,000 | 405,000 | 846,000 | 248,000 | 416,000 | 831,000 | 415,000 | 604,000 | 739,000 | 205,000 | 249,000 | 844,000 | 356,000 | 822,000 | 959,000 | 946,000 | 2,784,000 | 3,320,000 | 2,681,000 | 3,371,000 | 4,090,000 | 1,389,000 | 969,000 | 3,357,000 | |||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.001 par value; 3,000,000 shares authorized; no shares issued and outstanding at december 31, 2018 and 2017 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accrued collaboration charges | 1,560,000 | 2,192,000 | 1,841,000 | 1,702,000 | 1,946,000 | 1,907,000 | 2,495,000 | 3,398,000 | 3,420,000 | 3,537,000 | 2,498,000 | 1,901,000 | 626,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other accrued liabilities | 884,000 | 724,000 | 942,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.001 par value; 3,000,000 shares authorized; no shares issued and outstanding at december 31, 2017 and 2016 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
litigation settlement insurance recovery | 6,000,000 | 6,000,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liabilities and stockholders’ equity | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
litigation settlement payable | 6,250,000 | 6,250,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stockholders’ equity: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total stockholders’ equity | 113,008,000 | 117,251,000 | 128,912,000 | 130,305,000 | 136,485,000 | 147,894,000 | 118,356,000 | 125,175,000 | 137,178,000 | 144,583,000 | 150,892,000 | 61,876,000 | 68,407,000 | 76,059,000 | 99,772,000 | 114,201,000 | 130,913,000 | 146,603,000 | 175,207,000 | 191,060,000 | 207,657,000 | 192,735,000 | 154,670,000 | 164,322,000 | 173,745,000 | 172,577,000 | 179,250,000 | 191,964,000 | 205,139,000 | 213,049,000 | 217,973,000 | 175,913,000 | 184,340,000 | 199,314,000 | 131,868,000 | 129,740,000 | 122,063,000 | 91,171,000 | 106,454,000 | |||||||||||||||||||||||||||||||||||||||
accrued restructuring charges | 13,000 | 19,000 | 35,000 | 78,000 | 205,000 | 316,000 | 11,000 | 161,000 | 374,000 | 843,000 | 90,000 | 734,000 | 1,417,000 | 3,730,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accumulated other comprehensive income | 25,000 | 90,000 | 40,000 | 18,000 | 82,000 | -406,000 | -68,000 | -109,000 | -590,000 | -467,000 | -361,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred revenue | 35,000,000 | 35,000,000 | 175,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
fair value of derivatives | 1,000 | 290,000 | 143,000 | 258,000 | 50,000 | 26,000 | 74,000 | 30,000 | 38,000 | 64,000 | 137,000 | 428,000 | 668,000 | 707,000 | 764,000 | 667,000 | 839,000 | 897,000 | 863,000 | 701,000 | 2,533,000 | 3,502,000 | 3,711,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of marketable securities | 118,801,000 | 130,816,000 | 133,869,000 | 84,443,000 | 104,050,000 | 100,394,000 | 105,208,000 | 108,127,000 | 119,756,000 | 127,915,000 | 140,599,000 | 91,056,000 | 83,789,000 | 89,390,000 | 77,009,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
noncurrent portion of marketable securities | 15,801,000 | 6,496,000 | 7,464,000 | 5,726,000 | 3,283,000 | 16,712,000 | 32,133,000 | 37,921,000 | 39,592,000 | 43,186,000 | 33,911,000 | 19,856,000 | 34,100,000 | 40,447,000 | 54,669,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of prepaid assets | 1,438,000 | 2,121,000 | 2,840,000 | 2,996,000 | 4,408,000 | 5,855,000 | 10,089,000 | 7,662,000 | 5,794,000 | 4,060,000 | 3,718,000 | 5,879,000 | 3,070,000 | 3,888,000 | 2,343,000 | 2,074,000 | 2,810,000 | 2,586,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
noncurrent portion of prepaid assets | 108,000 | 438,000 | 854,000 | 1,364,000 | 1,867,000 | 1,966,000 | 2,372,000 | 2,567,000 | 2,897,000 | 755,000 | 931,000 | 226,000 | 565,000 | 735,000 | 3,212,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
investments in licensees | 2,000 | 169,000 | 504,000 | 194,000 | 437,000 | 932,000 | 1,328,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stock issuance obligation | 27,500,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of deferred revenue | 350,000 | 577,000 | 700,000 | 700,000 | 700,000 | 80,000 | 134,000 | 27,000 | 100,000 | 605,000 | 1,455,000 | 1,737,000 | 1,862,000 | 144,000 | 472,000 | 477,000 | 210,000 | 149,000 | 307,000 | 367,000 | 442,000 | 567,000 | 313,000 | 267,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.001 par value; 3,000,000 shares authorized; no shares | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
issued and outstanding at december 31, 2011 and 2010 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
131,443,148 and 122,616,729 shares issued and outstanding at | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
december 31, 2011 and 2010, respectively | 131,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accrued compensation | 2,855,000 | 2,305,000 | 1,641,000 | 6,186,000 | 2,817,000 | 2,246,000 | 1,534,000 | 1,757,000 | 2,399,000 | 1,844,000 | 1,973,000 | 1,441,000 | 893,000 | 1,434,000 | 1,082,000 | 1,276,000 | 953,000 | 572,000 | 2,024,000 | 1,304,000 | 478,000 | 606,000 | 462,000 | 329,000 | 761,000 | 1,508,000 | 651,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||
long-term debt | 3,194,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
noncurrent portion of deferred revenue | 175,000 | 350,000 | 58,000 | 65,000 | 85,000 | 91,000 | 98,000 | 442,000 | 698,000 | 1,674,000 | 458,000 | 665,000 | 707,000 | 751,000 | 781,000 | 872,000 | 923,000 | 1,002,000 | 1,063,000 | 996,000 | 1,046,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
issued and outstanding at december 31, 2010 and 2009 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
122,616,729 and 92,521,946 shares issued and outstanding at | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
december 31, 2010 and 2009, respectively | 123,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accrued liabilities (including amounts for related parties: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
2009-none, 2008-270) | 1,925,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of advance payment from related party for research and | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
development | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
issued and outstanding at december 31, 2009 and 2008 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
92,521,946 and 81,070,464 shares issued and outstanding at | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
december 31, 2009 and 2008, respectively | 92,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
2008-267, 2007-1,029) | 2,360,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of advance payment from related party for | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
research and development | 738,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
noncurrent portion of advance payment from related party | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
for research and development | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of advance payment from related party for research and development | 1,038,000 | 1,215,000 | 877,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
noncurrent portion of advance payment from related party for research and development | 921,000 | 1,657,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
equity investments in licensees | 100,000 | 110,000 | 148,000 | 330,000 | 325,000 | 489,000 | 330,000 | 274,000 | 427,000 | 367,000 | 347,000 | 314,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
equity investments in licensees and joint ventures | 218,000 | 217,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
intangible assets | 565,000 | 754,000 | 942,000 | 1,131,000 | 1,671,000 | 3,103,000 | 4,535,000 | 5,251,000 | 5,967,000 | 7,400,000 | 8,116,000 | 8,832,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of equipment loans | 82,000 | 112,000 | 129,000 | 146,000 | 162,000 | 169,000 | 189,000 | 220,000 | 281,000 | 528,000 | 565,000 | 710,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of research funding obligation | 1,472,000 | 1,694,000 | 2,001,000 | 2,454,000 | 3,615,000 | 4,798,000 | 4,380,000 | 4,525,000 | 4,742,000 | 4,862,000 | 4,845,000 | 4,698,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
commitments | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred compensation | -275,000 | -147,000 | -180,000 | -207,000 | -260,000 | -140,000 | -197,000 | -131,000 | -151,000 | -173,000 | -53,000 | -114,000 | -174,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
notes receivable from related parties | 135,000 | 139,000 | 143,000 | 147,000 | 67,000 | 67,000 | 64,000 | 208,000 | 366,000 | 244,000 | 255,000 | 265,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
noncurrent portion of equipment loans | 28,000 | 55,000 | 82,000 | 157,000 | 244,000 | 285,000 | 326,000 | 433,000 | 620,000 | 192,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
noncurrent portion of research funding obligation | 295,000 | 590,000 | 243,000 | 1,672,000 | 2,394,000 | 3,108,000 | 4,544,000 | 5,266,000 | 5,980,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
equity investments in licensees and joint venture | 484,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
fair value of warrants to purchase common stock | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.001 par value; 3,000,000 shares | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
authorized; no shares issued and outstanding | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
authorized; 52,220,332 shares issued and outstanding | 52,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible debentures | 16,320,000 | 16,310,000 | 16,305,000 | 16,300,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
additional paid-in-capital | 297,279,000 | 295,739,000 | 257,563,000 | 256,006,000 | 255,374,000 | 253,649,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
commitments stockholders’ equity: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
short-term investments | 31,424,000 | 33,317,000 | 48,755,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other current assets | 2,353,000 | 638,000 | 653,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term investments | 6,258,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
equity investment in licensees | 455,000 | 597,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
redeemable common stock | 1,585,000 |
The information provided in this report is taken from www.sec.gov and many other data providers. While we have conducted our best efforts to ensure that the parsed data is accurate, we cannot guarantee its accuracy. Please use caution and understand that any consequences of its use are your own responsibility.