7Baggers

Fate Therapeutics, Inc
(NASDAQ:FATE) 

FATE stock logo

Fate Therapeutics, Inc., a clinical-stage biopharmaceutical company, develops programmed cellular immunotherapies for cancer and immune disorders worldwide. Its NK- and T-cell immuno-oncology programs under development include FT516 for the treatment of acute myeloid leukemia (AML) B-cell lymphoma, ...

Founded: 2007
Full Time Employees: 178
Sector: Healthcare
Industry: Biotechnology
Pharmaceuticals
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At a glance:
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Income Statements:
Quarterly
Annual
    Unit: USD2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-09-30 2014-06-30 2014-03-31 2013-09-30 
                                                    
      collaboration revenue
    		1,369,000 1,741,000 1,907,000 1,629,000 1,860,000 3,074,000 6,772,000 1,925,000 1,676,000 1,944,000 933,000 58,980,000 44,356,000 14,981,000 18,549,000 18,414,000 17,069,000 14,225,000 13,412,000 11,142,000 15,896,000 7,558,000 5,465,000 2,515,000 2,802,000 2,429,000 2,817,000 2,632,000 1,661,000 1,026,000 1,027,000 1,026,000 1,027,000 1,026,000 1,026,000 1,027,000 1,027,000 1,026,000 1,027,000 1,322,000 1,076,000 1,026,000 329,000     209,000 
      operating expenses:
    		                                                
      research and development
    		25,425,000 25,838,000 27,430,000 29,136,000 33,609,000 34,650,000 34,604,000 32,138,000 31,816,000 34,275,000 40,876,000 65,629,000 87,191,000 79,817,000 81,307,000 72,139,000 69,515,000 53,130,000 48,023,000 44,852,000 38,982,000 30,694,000 26,669,000 29,278,000 25,209,000 23,202,000 21,631,000 17,728,000 14,095,000 13,637,000 16,816,000 11,476,000 9,887,000 8,578,000 7,927,000 7,966,000 6,230,000 6,804,000 6,782,000 6,636,000 5,433,000 5,003,000 4,857,000 4,568,000 4,080,000 3,968,000 4,522,000 3,378,000 
      general and administrative
    		10,665,000 10,638,000 11,445,000 13,773,000 15,262,000 20,801,000 17,251,000 20,855,000 17,935,000 18,948,000 22,622,000 21,943,000 21,584,000 21,555,000 20,351,000 20,742,000 16,936,000 15,718,000 12,168,000 12,500,000 10,313,000 8,351,000 7,503,000 7,729,000 6,671,000 6,346,000 5,270,000 5,350,000 4,307,000 4,081,000 3,816,000 3,604,000 3,384,000 2,788,000 2,669,000 3,032,000 2,451,000 2,611,000 2,249,000 2,602,000 2,555,000 2,351,000 2,690,000 2,756,000 1,904,000 2,072,000 2,415,000 1,979,000 
      total operating expenses
    		36,090,000 36,476,000 38,875,000 42,909,000 63,608,000 55,451,000 51,855,000 52,993,000 49,751,000 53,223,000 63,498,000 87,572,000 108,775,000 101,372,000 101,658,000 92,881,000 86,451,000 68,848,000 60,191,000 57,352,000 49,295,000 39,045,000 34,172,000 37,007,000 31,880,000 29,548,000 26,901,000 23,078,000 18,402,000 17,718,000 20,632,000 15,080,000 13,271,000 11,366,000 10,596,000 10,998,000 8,681,000 9,415,000 9,031,000 9,238,000 7,988,000 7,354,000 7,547,000 7,324,000 5,984,000 6,040,000 6,937,000 5,357,000 
      income from operations
    		-34,721,000 -34,735,000 -36,968,000 -41,280,000 -61,748,000 -52,377,000 -45,083,000 -51,068,000 -48,075,000 -51,279,000 -62,565,000 -28,592,000 -64,419,000 -86,391,000 -83,109,000 -74,467,000 -69,382,000 -54,623,000 -46,779,000 -46,210,000 -33,399,000 -31,487,000 -28,707,000 -34,492,000 -29,078,000 -27,119,000 -24,084,000 -20,446,000 -16,741,000 -16,692,000 -19,605,000 -14,054,000 -12,244,000 -10,340,000 -9,570,000 -9,971,000 -7,654,000 -8,389,000 -8,004,000 -7,916,000         
      yoy
    		-43.77% -33.68% -18.00% -19.17% 28.44% 2.14% -27.94% 78.61% -25.37% -40.64% -24.72% -61.60% -7.15% 58.16% 77.66% 61.15% 107.74% 73.48% 62.95% 33.97% 14.86% 16.11% 19.20% 68.70% 73.69% 62.47% 22.85% 45.48% 36.73% 61.43% 104.86% 40.95% 59.97% 23.26% 19.57% 25.96%             
      qoq
    		-0.04% -6.04% -10.45% -33.15% 17.89% 16.18% -11.72% 6.23% -6.25% -18.04% 118.82% -55.62% -25.43% 3.95% 11.61% 7.33% 27.02% 16.77% 1.23% 38.36% 6.07% 9.68% -16.77% 18.62% 7.22% 12.60% 17.79% 22.13% 0.29% -14.86% 39.50% 14.78% 18.41% 8.05% -4.02% 30.27% -8.76% 4.81% 1.11%          
      operating margin %
    		-Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% NaN% NaN% NaN% NaN% NaN% NaN% NaN% 0% 
      other income:
    		                                                
      interest income
    		2,220,000 2,575,000 2,921,000 3,336,000 3,874,000 4,438,000 4,827,000 4,149,000 4,414,000 4,697,000 4,381,000 3,694,000 2,880,000 1,787,000 757,000 418,000 297,000 289,000 346,000 377,000 346,000 447,000 635,000 972,000 1,314,000 910,000 1,015,000 1,091,000 1,144,000 339,000 376,000 331,000 159,000 152,000 137,000 111,000 43,000 37,000 31,000 27,000 3,000 4,000 2,000 1,000  1,000   
      change in fair value of stock price appreciation milestones
    		127,000 -90,000 -73,000 280,000 670,000 -13,000 1,556,000 -1,394,000 -645,000 1,049,000 393,000 1,718,000 5,176,000 891,000 5,881,000 8,359,000 464,000 11,026,000 -8,700,000 744,000 -20,058,000 -27,644,000                           
      other income
    		  50,000 43,000 5,051,000 274,000 273,000 309,000 184,000 363,000 5,036,000 4,299,000  150,000 366,000                                  
      total other income
    		2,347,000 2,485,000 2,898,000 3,659,000 9,595,000 4,699,000 6,656,000 3,064,000 3,953,000 6,109,000 9,810,000 9,711,000 8,056,000 2,828,000 7,004,000 8,777,000 761,000 11,315,000 -8,354,000 1,121,000 -19,712,000 -27,197,000 635,000 972,000 776,000 510,000 606,000 686,000                     
      net income
    		-32,374,000 -32,250,000 -34,070,000 -37,621,000 -52,153,000 -47,678,000 -38,427,000 -48,004,000 -44,122,000 -45,170,000 -52,755,000 -18,881,000 -56,363,000 -83,563,000 -76,105,000 -65,690,000 -68,621,000 -43,308,000 -55,133,000 -45,089,000 -53,111,000 -58,684,000 -28,072,000 -33,520,000 -28,302,000 -26,609,000 -23,478,000 -19,760,000 -16,027,000 -16,782,000 -19,654,000 -14,135,000 -12,497,000 -10,684,000 -9,645,000 -10,126,000 -7,940,000 -8,737,000 -8,408,000 -8,377,000         
      yoy
    		-37.92% -32.36% -11.34% -21.63% 18.20% 5.55% -27.16% 154.25% -21.72% -45.94% -30.68% -71.26% -17.86% 92.95% 38.04% 45.69% 29.20% -26.20% 96.40% 34.51% 87.66% 120.54% 19.57% 69.64% 76.59% 58.56% 19.46% 39.79% 28.25% 57.08% 103.77% 39.59% 57.39% 22.28% 14.71% 20.88%             
      qoq
    		0.38% -5.34% -9.44% -27.86% 9.39% 24.07% -19.95% 8.80% -2.32% -14.38% 179.41% -66.50% -32.55% 9.80% 15.85% -4.27% 58.45% -21.45% 22.28% -15.10% -9.50% 109.05% -16.25% 18.44% 6.36% 13.34% 18.82% 23.29% -4.50% -14.61% 39.04% 13.11% 16.97% 10.77% -4.75% 27.53% -9.12% 3.91% 0.37%          
      net income margin %
    		-Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% NaN% NaN% NaN% NaN% NaN% NaN% NaN% 0% 
      other comprehensive loss:
    		                                                
      unrealized gain on available-for-sale securities
    		-37,000 91,000   -567,000 1,257,000 -228,000 -209,000 514,000 88,000 59,000 1,208,000 1,399,000 128,000 -531,000  -689,000 13,000 174,000 -330,000 -242,000 -311,000 481,000 120,000 -29,000 -42,000 93,000 2,000 12,000 1,000   -3,000 26,000 -5,000 -33,000 750 -8,000 -3,000 14,000         
      comprehensive loss
    		-32,411,000 -32,159,000 -34,199,000 -37,698,000 -52,720,000 -46,421,000 -38,655,000 -48,213,000 -43,608,000 -45,082,000 -52,696,000 -17,673,000 -54,964,000 -83,435,000 -76,636,000 -67,778,000 -69,310,000 -43,295,000 -54,959,000 -45,419,000 -53,353,000 -58,995,000 -27,591,000 -33,400,000 -28,331,000 -26,651,000 -23,385,000 -19,758,000 -16,015,000 -16,781,000 -19,656,000 -14,145,000 -12,487,000 -10,658,000 -9,650,000 -10,159,000 -7,944,000 -8,745,000 -8,411,000 -8,363,000         
      net loss per common share, basic and diluted
    		-270 -270 -290 -320 -450 -400 -330 -470 -450 -460 -540 -190 -580 -860 -790 -680 -720 -450 -580 -480 -610 -680 -350 -440 -380 -400 -360 -300 -240 -310 -370 -270 -280 -260 -230 -240 -200 -270 -290 -290 -260 -240 -330 -380 -320 -300 -340 -4,810 
      weighted-average common shares used to compute basic and diluted net loss per share
    		 118,998,693 118,528,046 118,375,540  117,769,161 117,468,124 101,104,345  98,568,012 98,400,355 98,054,687  97,023,506 96,704,413 96,343,529  95,409,201 94,326,648 93,431,877  86,887,280 79,304,627 75,886,964  66,929,503 65,213,364 64,920,621  54,185,022 53,130,518 52,763,306  41,428,845 41,406,367 41,388,329  32,090,174 28,868,464 28,777,790  28,650,356 23,920,630 20,554,478 20,489,181 20,467,782 20,346,856  
      unrealized loss on available-for-sale securities
    		  -129,000 -77,000            -2,088,000               -2,000 -10,000                 
      other comprehensive income:
    		                                                
      interest expense
    		                        -538,000 -400,000 -409,000 -405,000 -430,000 -429,000 -425,000 -412,000 -412,000 -378,000 -212,000 -266,000 -329,000 -385,000 -435,000 -488,000         
      loss on extinguishment of debt
    		                                 -118,000               
      total other expense
    		                            -55,000 -90,000 -49,000 -81,000 -253,000 -344,000 -75,000 -155,000 -286,000 -348,000 -404,000 -461,000         
      net loss and comprehensive loss
    		                                        -7,446,000 -6,886,000 -7,779,000 -7,881,000 -6,603,000 -6,067,000 -6,980,000 -6,073,000 
      revenues:
    		                                                
      grant revenue
    		                                                
      total revenue
    		                                               209,000 
      yoy
    		                                                
      qoq
    		                                            NaN% NaN% NaN%  
      change in fair value of exchangeable shares
    		                                                
      change in fair value of warrant liability
    		                                                
      income from 48d tax credit
    		                                                
      other income (expense)
    		                                                
      weighted-average shares used for eps calculation
    		                                               1,262,546,000 
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-09-30 2014-06-30 2014-03-31 2013-09-30 
                                                      
        assets
      		                                                
        current assets:
      		                                                
        cash and cash equivalents
      		46,628,000 40,622,000 41,249,000 44,920,000 36,056,000 37,909,000 36,917,000 121,322,000 41,870,000 33,334,000 46,802,000 42,020,000 61,333,000 82,093,000 55,275,000 64,741,000 133,583,000 129,180,000 76,654,000 106,413,000 167,347,000 349,130,000 433,074,000 83,366,000 99,814,000 249,588,000 71,435,000 183,033,000 190,514,000 183,247,000 36,162,000 32,912,000 88,952,000 43,231,000 31,063,000 40,608,000 88,609,000 37,099,000 35,870,000 39,487,000 64,809,000 72,857,000 81,176,000 42,349,000 45,530,000 42,012,000 47,881,000 19,082,000 
        accounts receivable
      		916,000 682,000 1,395,000 2,406,000 3,539,000 4,127,000 1,048,000 858,000 1,826,000 1,538,000 2,833,000 13,500,000 38,480,000 10,223,000 13,126,000 13,850,000 8,676,000 7,311,000 10,303,000 6,945,000 5,515,000 3,243,000 1,717,000     500,000 500,000 500,000  500,000          846,000       
        short-term investments
      		157,029,000 174,801,000 181,581,000 195,505,000 243,012,000 259,014,000 267,962,000 262,222,000 273,305,000    374,894,000                      39,950,000 41,692,000 3,503,000 9,520,000 10,060,000 16,125,000         
        prepaid expenses and other current assets
      		4,131,000 5,146,000 6,172,000 5,386,000 9,302,000 9,244,000 13,461,000 9,973,000 14,539,000 12,902,000 11,414,000 15,490,000 27,367,000 19,970,000 17,181,000 11,453,000 8,826,000 7,701,000 7,369,000 7,236,000 5,892,000 4,729,000 5,099,000 4,965,000 5,662,000 2,810,000 3,170,000 2,897,000 3,689,000 2,237,000 2,015,000 1,491,000 1,647,000 825,000 848,000 1,137,000 1,211,000 780,000 1,162,000 955,000 843,000 482,000 395,000 443,000 94,000 233,000 382,000 304,000 
        total current assets
      		208,704,000 221,251,000 230,397,000 248,217,000 291,909,000 310,294,000 319,388,000 394,375,000 331,540,000 364,174,000 392,182,000 437,888,000 502,074,000 535,329,000 599,157,000 599,075,000 633,412,000 693,713,000 713,268,000 804,316,000 494,323,000 496,777,000 540,225,000 208,249,000 227,089,000 305,633,000 165,178,000 186,430,000 205,196,000 213,929,000 80,034,000 90,625,000 102,596,000 70,039,000 71,861,000 83,437,000 93,323,000 47,399,000 47,092,000 56,567,000 65,652,000 74,185,000 81,571,000 42,792,000 45,624,000 42,245,000 48,263,000 19,386,000 
        long-term investments
      		1,472,000 10,305,000 26,097,000 32,286,000 27,657,000 33,607,000 47,162,000 7,595,000 980,000  7,291,000 3,912,000 4,942,000 13,939,000 11,925,000 67,942,000 100,664,000 124,877,000 149,501,000 98,284,000  13,233,000  16,139,000 39,440,000                        
        property and equipment
      		56,925,000 59,475,000 61,097,000 62,762,000 64,384,000 82,392,000 87,534,000 92,116,000 96,836,000 101,707,000 106,331,000 108,594,000 110,020,000 109,118,000 103,116,000 97,857,000 91,529,000 74,617,000 59,213,000 47,950,000 32,308,000 20,710,000 15,932,000 11,896,000 11,419,000 9,653,000 9,225,000 8,402,000 5,125,000 3,798,000 2,894,000 2,649,000 2,550,000 2,490,000 1,945,000 1,746,000 1,579,000 1,750,000 1,940,000 1,992,000 2,160,000 2,072,000 1,766,000 1,544,000 1,240,000 1,159,000 1,264,000 789,000 
        operating lease right-of-use assets
      		41,609,000 42,413,000 43,814,000 45,178,000 46,508,000 58,441,000 59,547,000 60,620,000 61,675,000 62,721,000 63,743,000 64,682,000 66,069,000 67,378,000 68,493,000 69,475,000 70,720,000 64,970,000 66,184,000 67,295,000 67,084,000 67,130,000 68,229,000 69,200,000 22,752,000 23,160,000 23,560,000 23,955,000                     
        restricted cash
      		10,227,000 10,227,000 10,227,000 10,227,000 10,227,000 10,227,000 15,177,000 15,177,000 15,177,000 15,177,000 15,177,000 15,227,000 15,227,000 15,227,000 15,227,000 15,227,000 15,227,000 15,227,000 15,227,000 15,227,000 15,227,000 15,227,000 15,227,000 15,227,000 227,000 227,000 227,000 227,000 227,000 227,000 227,000 122,000 122,000 122,000 122,000 122,000 122,000 122,000 122,000 122,000 122,000 122,000 122,000 122,000 122,000 122,000 122,000 122,000 
        other assets
      		    9,000 9,000 9,000 9,000 9,000 9,000 33,000 33,000 33,000 33,000 33,000 33,000 33,000 9,000 9,000 9,000 9,000 9,000 9,000 9,000 9,000 9,000   526,000   24,000 24,000 24,000 24,000 24,000 24,000 24,000 24,000 24,000 24,000 24,000 24,000 32,000 24,000 25,000  2,743,000 
        total assets
      		318,937,000 343,671,000 371,632,000 398,670,000 440,694,000 494,970,000 528,817,000 569,892,000 506,217,000 543,788,000 584,757,000 630,336,000 705,561,000 749,349,000 807,059,000 858,386,000 921,455,000 984,571,000 1,015,666,000 1,045,964,000 622,457,000 626,443,000 653,594,000 321,890,000 302,274,000 340,207,000 199,877,000 220,865,000 213,032,000 219,954,000 83,155,000 93,420,000 105,292,000 72,675,000 73,952,000 85,329,000 95,048,000 49,295,000 49,178,000 58,705,000 67,958,000 76,403,000 83,483,000 44,490,000 47,010,000 43,551,000 49,649,000 23,040,000 
        liabilities and stockholders’ equity
      		                                                
        current liabilities:
      		                                                
        accounts payable
      		2,656,000 3,504,000 4,040,000 4,190,000 9,365,000 6,349,000 5,495,000 6,765,000 4,719,000 5,706,000 7,506,000 9,855,000 8,265,000 9,593,000 8,420,000 11,444,000 8,612,000 6,439,000 5,771,000 8,998,000 6,283,000 3,717,000 13,563,000 5,173,000 5,822,000 5,715,000 5,410,000 5,367,000 4,205,000 5,236,000 3,510,000 2,160,000 1,678,000 2,198,000 1,177,000 2,470,000 934,000 1,200,000 1,998,000 1,975,000 996,000 1,280,000 1,507,000 1,271,000 1,157,000 980,000 1,330,000  
        accrued expenses
      		20,024,000 17,571,000 18,182,000 17,213,000 21,348,000 23,580,000 22,654,000 32,043,000 27,514,000 28,540,000 29,469,000 31,513,000 53,932,000 50,149,000 40,524,000 35,110,000 42,412,000 54,003,000 25,736,000 20,931,000 15,564,000 14,782,000 11,618,000 11,770,000 14,697,000 13,843,000 9,834,000 9,950,000 10,926,000 9,638,000 8,376,000 7,440,000 7,254,000 5,413,000 4,769,000 4,699,000 3,957,000 3,343,000 2,355,000 2,038,000 2,439,000 2,317,000 2,491,000 1,827,000 2,010,000 1,948,000 1,641,000 137,000 
        cirm award liability, current portion
      		8,448,000 2,280,000 795,000          4,000,000 3,200,000 3,200,000 3,200,000 3,200,000 3,200,000 3,200,000 3,200,000 3,200,000 3,160,000 3,160,000 3,160,000 2,808,000 2,106,000 2,106,000 2,106,000                     
        deferred revenue
      		381,000 5,000  212,000 393,000 600,000  159,000 685,000 1,110,000 1,929,000                  7,500,000 8,000,000  198,000 724,000 1,250,000 1,776,000 2,303,000 2,829,000 3,355,000 3,881,000 4,408,000 4,934,000 5,460,000 5,986,000      
        operating lease liabilities, current portion
      		4,562,000 4,751,000 5,656,000 6,544,000 7,416,000 6,893,000 6,644,000 6,402,000 6,176,000 5,977,000 5,786,000 5,545,000 5,628,000 5,755,000 5,717,000 5,582,000 5,577,000 4,697,000 5,068,000 4,412,000 3,355,000 2,330,000 2,355,000 1,898,000 1,692,000 1,632,000 1,572,000 1,200,000                     
        total current liabilities
      		36,071,000 28,111,000 28,673,000 28,159,000 38,522,000 37,422,000 34,793,000 45,369,000 39,094,000 41,333,000 44,690,000 48,651,000 114,051,000 103,938,000 91,518,000 77,911,000 81,284,000 91,884,000 105,600,000 94,577,000 85,564,000 54,195,000 45,322,000 24,924,000 27,806,000 40,595,000 29,418,000 29,140,000 27,263,000 22,672,000 16,273,000 12,588,000 11,049,000 9,716,000 8,052,000 16,897,000 15,187,000 14,678,000 14,327,000 13,886,000 13,441,000 12,596,000 11,315,000 6,413,000 3,912,000 3,812,000 4,354,000 9,491,000 
        cirm award liability, net of current portion
      		2,112,000 6,590,000 5,600,000           800,000 800,000 800,000 800,000 800,000 800,000 800,000 800,000 790,000 790,000 790,000 702,000 1,404,000 1,404,000 1,404,000 1,404,000 856,000                   
        operating lease liabilities, net of current portion
      		73,287,000 74,494,000 75,675,000 76,785,000 77,849,000 92,085,000 93,918,000 95,668,000 97,360,000 98,977,000 100,562,000 102,070,000 103,710,000 105,164,000 106,587,000 107,939,000 109,241,000 104,360,000 105,405,000 106,512,000 93,943,000 83,156,000 78,683,000 73,834,000 25,235,000 25,670,000 26,098,000 26,517,000                     
        stock price appreciation milestones
      		283,000 410,000 320,000 247,000 527,000 1,197,000 1,184,000 2,740,000 1,346,000 701,000 1,750,000 2,143,000  9,037,000 9,928,000 15,809,000                                 
        commitments and contingencies
      		                                                
        stockholders’ equity:
      		                                                
        preferred stock, 0.001 par value...
      		3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000            
        common stock, 0.001 par value...
      		115,000 115,000 115,000 115,000 114,000 114,000 114,000 114,000 99,000 99,000 99,000 98,000 97,000 97,000 97,000 97,000 96,000 95,000 94,000 94,000 88,000 87,000 87,000 76,000 76,000 75,000 65,000 65,000 65,000 65,000 53,000 53,000 53,000 41,000 41,000 41,000 41,000 34,000 29,000 29,000 29,000 29,000 29,000 21,000 21,000 21,000 20,000 1,000 
        additional paid-in capital
      		1,741,259,000 1,735,730,000 1,730,869,000 1,723,715,000 1,716,335,000 1,707,215,000 1,695,450,000 1,685,928,000 1,580,032,000 1,570,784,000 1,560,680,000 1,547,702,000 1,536,497,000 1,515,597,000 1,494,642,000 1,470,916,000 1,448,584,000 1,430,769,000 1,409,214,000 1,392,279,000 941,216,000 927,784,000 918,535,000 636,062,000 628,200,000 623,156,000 455,999,000 450,925,000  443,244,000 304,371,000 297,885,000  252,019,000 250,825,000 249,820,000  193,242,000 182,258,000 181,445,000  179,904,000 179,097,000 141,503,000 139,714,000 139,173,000 138,646,000 14,367,000 
        accumulated other comprehensive income
      		116,000 153,000 62,000 191,000 268,000 835,000 -422,000 -194,000 15,000                             3,000 11,000 14,000         
        accumulated deficit
      		-1,534,309,000 -1,501,935,000 -1,469,685,000 -1,435,615,000 -1,397,994,000 -1,345,841,000 -1,298,163,000 -1,259,736,000 -1,211,732,000 -1,167,610,000 -1,122,440,000 -1,069,685,000 -1,050,804,000 -994,441,000 -910,878,000 -834,773,000 -769,083,000 -700,462,000 -657,154,000 -602,021,000 -556,932,000 -503,821,000 -445,137,000 -417,065,000 -383,545,000 -355,243,000 -328,634,000 -305,156,000 -285,396,000 -269,369,000 -252,587,000 -232,933,000 -218,798,000 -206,301,000 -195,617,000 -185,972,000 -175,846,000 -167,906,000 -159,169,000 -150,761,000 -142,384,000        
        total stockholders’ equity
      		207,184,000 234,066,000 261,364,000 288,409,000 318,726,000 362,326,000 396,982,000 426,115,000 368,417,000 402,777,000 437,755,000 477,472,000 483,939,000 518,003,000 580,483,000 633,393,000 678,838,000 730,332,000 752,071,000 790,095,000 384,445,000 424,365,000 474,111,000 219,218,000 244,756,000 268,042,000 127,526,000 145,837,000 160,469,000 173,929,000 51,825,000 64,995,000 77,189,000 45,749,000 55,213,000 63,858,000 73,154,000 25,373,000 23,129,000 30,727,000 38,038,000 44,995,000 51,074,000 21,251,000 33,576,000 39,638,000 45,177,000  
        total liabilities and stockholders’ equity
      		318,937,000 343,671,000 371,632,000 398,670,000 440,694,000 494,970,000 528,817,000 569,892,000 506,217,000 543,788,000 584,757,000 630,336,000 705,561,000 749,349,000 807,059,000 858,386,000 921,455,000 984,571,000 1,015,666,000 1,045,964,000 622,457,000 626,443,000 653,594,000 321,890,000 302,274,000 340,207,000 199,877,000 220,865,000 213,032,000 219,954,000 83,155,000 93,420,000 105,292,000 72,675,000 73,952,000 85,329,000 95,048,000 49,295,000 49,178,000 58,705,000 67,958,000 76,403,000 83,483,000 44,490,000   49,649,000  
        cirm award liability
      		   5,070,000 5,070,000 1,940,000 1,940,000                        600,000                  
        collaboration contract assets
      		            7,196,000 8,325,000 9,108,000 8,777,000 9,870,000 11,158,000 12,264,000 12,883,000 13,506,000 13,357,000 13,972,000                          
        short-term investments and related maturity receivables
      		         316,400,000 331,133,000 366,878,000  423,043,000 513,575,000 509,031,000 482,327,000 549,521,000 618,942,000 683,722,000 315,569,000 139,675,000 100,335,000 119,918,000 121,613,000 53,235,000 90,573,000  10,493,000 27,945,000 41,857,000 55,722,000 11,997,000 25,983,000               
        accumulated other comprehensive loss
      		         -499,000 -587,000 -646,000 -1,854,000 -3,253,000 -3,381,000 -2,850,000             -2,000 -14,000 -15,000 -13,000 -3,000 -13,000 -39,000 -34,000 -1,000            
        deferred revenue, current portion
      		           1,738,000 42,226,000 35,241,000 33,657,000 22,575,000 21,483,000 23,545,000 23,032,000 21,033,000 21,144,000 17,121,000 14,626,000 2,923,000 2,787,000 3,367,000 5,049,000 6,576,000                     
        deferred revenue, net of current portion
      		             12,407,000 17,743,000 22,534,000 27,124,000 32,563,000 38,925,000 43,025,000 46,021,000 49,378,000 54,688,000 3,124,000 3,775,000 4,496,000 5,244,000 6,380,000                     
        stock price appreciation milestones, net of current portion
      		            3,861,000    24,168,000 24,632,000 12,865,000 10,955,000 11,684,000 14,559,000                           
        stock price appreciation milestones, current portion
      		                  42,793,000 36,003,000 36,018,000 13,085,000                           
        accumulated other comprehensive gain
      		                -762,000 -73,000 -86,000 -260,000 70,000 312,000 623,000 142,000 22,000 51,000 93,000                      
        collaboration contract asset
      		                       1,170,000 1,338,000 1,525,000 1,687,000 1,851,000 1,958,000 2,000,000                   
        long-term debt, current portion
      		                         13,932,000 5,447,000 3,941,000  3,264,000 2,011,000 758,000    7,620,000  8,025,000 7,864,000 7,705,000  6,494,000 5,156,000 3,256,000 611,000 746,000 1,240,000 1,971,000 
        deferred rent
      		                            3,401,000 2,441,000 1,462,000 1,303,000 1,347,000 1,090,000 821,000 543,000 101,000 99,000 97,000 42,000 58,000 75,000 91,000 100,000 76,000 101,000 118,000 153,000 
        long-term debt
      		                          9,469,000 10,958,000  11,601,000 12,835,000 14,069,000  14,789,000 6,676,000 1,081,000  4,610,000 6,676,000 8,700,000  12,635,000 14,539,000 16,414,000 9,389,000    
        current portion of cirm award liability
      		                            2,106,000 1,284,000                   
        current portion of deferred rent
      		                               125,000 12,000  1,000 3,000 4,000 5,000 5,000 63,000 54,000 45,000 35,000 26,000 77,000 69,000 61,000 45,000 
        current portion of deferred revenue
      		                            7,588,000 3,250,000 1,776,000 2,105,000 2,105,000 2,105,000 2,105,000 2,105,000 2,105,000 2,105,000 2,105,000 2,105,000 2,401,000 2,451,000 2,105,000      
        long–term debt, current portion
      		                            2,438,000        8,187,000    7,550,000        
        long–term debt, net of current portion
      		                            12,446,000    14,808,000    2,501,000    10,688,000        
        additional paid–in capital
      		                            445,799,000    295,934,000    248,957,000    180,393,000        
        repurchase liability for unvested equity awards
      		                                        1,000 9,000 21,000 33,000 57,000 69,000 82,000 106,000 
        total liabilities and stockholder’s equity
      		                                            47,010,000 43,551,000   
        deficit accumulated during the development stage
      		                                                
        liabilities, convertible preferred stock and stockholders’ deficit
      		                                                
        accounts payable and accrued expenses
      		                                               3,725,000 
        convertible notes, net of discount
      		                                               3,481,000 
        preferred stock warrant liability
      		                                               163,000 
        exchangeable share liability
      		                                               2,885,000 
        long-term debt, less current portion
      		                                               250,000 
        long-term convertible notes
      		                                               20,000,000 
        convertible preferred stock, 0.001 par value...
      		                                               56,526,000 
        stockholders’ deficit:
      		                                                
        total stockholders’ deficit
      		                                                
        total liabilities, convertible preferred stock and stockholders’ deficit
      		                                               23,040,000 
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-09-30 2014-06-30 2014-03-31 
                                                       
          operating activities:
        		                                               
          net loss
        		-32,374,000 -32,250,000 -34,070,000 -37,621,000 -52,153,000 -47,678,000 -38,427,000 -48,004,000 -44,122,000 -45,170,000 -52,755,000 -18,881,000 -56,363,000 -83,563,000 -76,105,000 -65,690,000 -68,621,000 -43,308,000 -55,133,000 -45,089,000 -53,111,000 -58,684,000 -28,072,000 -33,520,000 -28,302,000 -26,609,000 -23,478,000 -19,760,000 -16,027,000 -16,782,000 -19,654,000 -14,135,000 -12,497,000 -10,684,000 -9,645,000 -10,126,000 -7,940,000 -8,737,000 -8,408,000 -8,377,000 -7,446,000    -6,603,000 -6,067,000 -6,980,000 
          adjustments to reconcile net loss to net cash from operating activities
        		                                               
          depreciation and amortization
        		3,063,000 3,227,000 3,278,000 3,333,000 4,813,000 4,607,000 4,721,000 4,821,000 4,885,000 4,740,000 4,466,000 4,191,000 4,842,000 3,193,000 2,962,000 2,761,000 2,206,000 1,519,000 1,166,000 959,000 861,000 773,000 748,000 705,000 623,000 587,000 543,000 440,000 327,000 310,000 281,000 286,000 290,000 244,000 231,000 206,000 203,000 218,000 233,000 227,000 210,000 187,000 162,000 128,000 115,000 133,000 123,000 
          stock–based compensation
        		                                               
          accretion and amortization of premiums and discounts on investments
        		-881,000 -810,000 -847,000 -1,068,000 -1,530,000 -2,196,000 -2,723,000 -2,631,000 -2,906,000 -3,257,000 -2,940,000 -2,295,000 -1,245,000 -409,000 525,000 873,000 1,072,000 1,366,000 1,489,000 1,140,000 855,000 303,000 247,000 271,000 80,000                       
          deferred revenue
        		377,000 4,000 -212,000 -181,000 -207,000 0 -160,000 -525,000 -425,000 -820,000 192,000 -40,488,000 -5,422,000 -3,752,000 6,290,000 -3,497,000 -7,502,000 -5,849,000 -2,101,000 -3,107,000 666,000 -2,816,000 63,268,000 -515,000 -1,301,000 -2,430,000 -2,663,000 -2,132,000 3,838,000 9,474,000 -527,000 -526,000 -526,000 -526,000 -527,000 -526,000 -526,000 -526,000 -527,000 -822,000 -576,000 -180,000      
          change in fair value of stock price appreciation milestones
        		-127,000 90,000 73,000 -280,000 -670,000 13,000 -1,556,000 1,394,000 645,000 -1,049,000 -393,000 -1,718,000 -5,176,000 -891,000 -5,881,000 -8,359,000 -464,000 -11,026,000 8,700,000 -744,000 20,058,000                           
          impairment of long-lived assets
        		                                               
          loss on disposal of property and equipment
        		45,000 0   0                                           
          changes in assets and liabilities:
        		                                               
          accounts receivable
        		-233,000 713,000 1,010,000 1,134,000 588,000 -2,479,000 -190,000 968,000 -288,000 1,296,000 10,666,000 24,980,000 -28,257,000 2,903,000 724,000 -5,174,000 -1,365,000 2,993,000 -3,358,000 -1,430,000 -2,272,000 -1,526,000   0 0   0   -500,000                
          prepaid expenses and other assets
        		1,014,000 1,026,000 -786,000 3,925,000 -57,000 4,216,000 -3,487,000 4,565,000 -1,636,000 -1,465,000 4,076,000 11,901,000 -7,406,000 -2,788,000 -5,729,000 -2,407,000 -1,131,000 -252,000 -368,000 -1,301,000 -1,378,000 584,000 -13,424,000 636,000 -2,778,000 348,000 -273,000 792,000                    
          accounts payable and accrued expenses
        		865,000 -550,000 484,000 -9,826,000 655,000 1,871,000 320,000 -4,507,000 -1,893,000 -2,281,000 -4,373,000 -20,393,000 3,387,000 10,279,000 4,079,000 -3,493,000 -10,380,000 6,737,000 2,606,000 6,944,000 1,072,000 -7,430,000 8,120,000 -3,316,000 1,511,000 3,659,000 365,000 -1,258,000 336,000 1,175,000 2,070,000 673,000 1,554,000 -184,000 -536,000 1,677,000 217,000 176,000 378,000 790,000 -282,000 -97,000 587,000 269,000 228,000 -35,000 43,000 
          right-of-use assets and lease liabilities
        		-591,000 -685,000 -635,000 -606,000 -3,095,000 -480,000 -434,000 -412,000 -372,000 -371,000 -329,000 -336,000 -271,000 -270,000 -235,000 -52,000 11,000 -201,000 660,000 1,933,000 1,974,000 1,960,000 1,959,000 1,985,000 32,000 33,000 348,000 361,000                    
          net cash from operating activities
        		-23,314,000 -24,374,000 -24,587,000 -33,809,000 -27,799,000 -29,419,000 -32,306,000 -33,350,000 -36,637,000 -38,273,000 -28,493,000 -28,860,000 -75,389,000 -55,047,000 -53,159,000 -64,613,000 -70,293,000 -33,375,000 -32,106,000 -27,096,000 -20,664,000 -30,733,000 38,841,000 -26,673,000 -25,535,000 -19,838,000 -20,309,000 -17,493,000 -11,020,000 -3,556,000 -11,523,000 -12,551,000 -10,721,000 -9,857,000 -8,872,000 -7,455,000 -7,551,000 -7,516,000 -7,504,000 -7,252,000        
          capital expenditures
        		-1,192,000 -2,798,000 -1,024,000 -541,000 26,000 -581,000 37,000 -72,000 -181,000 -1,009,000 -2,199,000 -2,596,000 -7,610,000 -8,157,000 -12,037,000 -6,707,000 -17,620,000 -12,548,000 -14,808,000 -1,357,000 -1,969,000 57,000 -807,000 -727,000 -2,792,000 -1,513,000 -2,224,000 -264,000 -1,117,000 -724,000 -278,000 -184,000 -797,000 -362,000 -411,000 -155,000 -40,000 -33,000 -206,000 -178,000        
          free cash flows
        		-24,506,000 -27,172,000 -25,611,000 -34,350,000 -27,773,000 -30,000,000 -32,269,000 -33,422,000 -36,818,000 -39,282,000 -30,692,000 -31,456,000 -82,999,000 -63,204,000 -65,196,000 -71,320,000 -87,913,000 -45,923,000 -46,914,000 -28,453,000 -22,633,000 -30,676,000 38,034,000 -27,400,000 -28,327,000 -21,351,000 -22,533,000 -17,757,000 -12,137,000 -4,280,000 -11,801,000 -12,735,000 -11,518,000 -10,219,000 -9,283,000 -7,610,000 -7,591,000 -7,549,000 -7,710,000 -7,430,000        
          investing activities
        		                                               
          proceeds from sale of property and equipment
        		237,000 3,000                                              
          purchases of property and equipment
        		-1,192,000 -2,203,000 -1,362,000 -1,196,000 -98,000 -495,000 -51,000 -86,000 -181,000 -565,000 -2,199,000 -3,208,000 -6,677,000 -8,676,000 -10,129,000 -10,084,000 -18,369,000 -14,735,000 -13,619,000 -3,981,000 -2,272,000 -954,000 -636,000 -1,070,000 -2,590,000 -1,264,000 -1,795,000 -1,746,000                    
          purchases of investments
        		-37,731,000 -57,975,000 -50,813,000 -48,624,000 -38,005,000 -64,744,000 -128,666,000 -86,335,000 -49,966,000 -102,130,000 -92,262,000 -114,452,000 -107,102,000 -101,579,000 -63,949,000 -132,166,000 -173,447,000 -165,468,000 -99,337,000 -529,907,000 -185,007,000                           
          maturities of investments
        		66,316,000 81,447,000 71,644,000 92,493,000 60,919,000 90,700,000 75,344,000 103,735,000 95,500,000 127,500,000 127,628,000 127,000,000 166,891,000 190,633,000 114,365,000 135,224,000 263,094,000 258,162,000 111,584,000 62,000,000 21,250,000 39,150,000 35,956,000 24,844,000                        
          net cash from investing activities
        		27,630,000 21,272,000 19,591,000 42,673,000 22,816,000 25,461,000 -53,373,000 17,314,000 45,353,000 24,805,000 33,167,000 9,340,000 53,112,000 80,378,000 40,287,000 -7,026,000 71,278,000 77,959,000 -1,372,000 -471,888,000 -166,029,000 -54,141,000 35,320,000 23,774,000 -110,516,000 36,286,000 -91,977,000 8,754,000 16,383,000 13,276,000 13,722,000 -43,844,000 13,203,000 13,638,000 1,339,000 -38,376,000 5,978,000 458,000 5,794,000 -16,344,000        
          financing activities
        		                                               
          issuance of common stock from equity incentive plans, net of issuance costs
        		    0 0 -4,000 299,000 -180,000 0 58,000 207,000 1,517,000 1,487,000 3,406,000 2,797,000 3,449,000 7,942,000 3,718,000 5,605,000 4,885,000 1,200,000 2,559,000 1,011,000  163,000 688,000 1,258,000  1,133,000 175,000 606,000  106,000 32,000 34,000  24,000 -4,000 147,000        
          proceeds from public offering of common stock, net of issuance costs
        		    0 0 -662,000 75,193,000         -31,000 0   0 -270,000   -136,000                0 -143,000      
          proceeds from issuance of pre-funded warrants, net of issuance costs
        		    0 0 0 19,996,000         0 0                              
          proceeds from ft819 cirm award
        		    3,130,000 0                                          
          proceeds from ft836 cirm award
        		200,000 2,475,000                                              
          net cash from financing activities
        		1,690,000 2,475,000   3,130,000 0 1,274,000 95,488,000 -180,000 0 58,000 207,000 1,517,000 1,487,000 3,406,000 2,797,000 3,418,000 7,942,000 3,719,000 438,050,000 4,910,000 930,000 275,547,000 1,451,000 -13,723,000 161,705,000 688,000 1,258,000 1,904,000    43,239,000 8,387,000 -2,012,000 -2,170,000 53,083,000 8,287,000 -1,907,000 -1,726,000 -900,000 -533,000 36,961,000 75,000    
          net change in cash, cash equivalents and restricted cash
        		6,006,000 -627,000 -3,671,000 8,864,000 -1,853,000 -3,958,000 -84,405,000 79,452,000 8,536,000 -13,468,000 4,732,000 -19,313,000 -20,760,000 26,818,000 -9,466,000 -68,842,000 4,403,000 52,526,000 -29,759,000 -60,934,000 -181,783,000 -83,944,000 349,708,000 -1,448,000 -149,774,000 178,153,000 -111,598,000 -7,481,000 7,267,000 147,085,000 3,355,000 -56,040,000 45,721,000 12,168,000              
          cash, cash equivalents and restricted cash at beginning of the year
        		                                               
          cash, cash equivalents and restricted cash at end of the year
        		                                               
          supplemental schedule of noncash investing and financing activities
        		                                               
          purchases of property and equipment in accounts payable
        		 -595,000 338,000 655,000 124,000 -86,000 88,000 14,000  -444,000 0 612,000 -933,000 519,000 -1,908,000 3,377,000 749,000 2,187,000 -1,189,000 2,624,000 303,000 1,011,000 -171,000 343,000 -202,000 -249,000 -429,000 1,482,000                    
          operating activities
        		                                               
          adjustments to reconcile net loss to net cash from operating activities:
        		                                               
          stock-based compensation
        		 4,861,000 7,154,000 7,381,000  11,765,000 9,630,000 10,981,000  10,104,000 12,897,000 10,983,000  19,468,000 20,542,000 19,331,000  13,540,000 13,254,000 12,976,000  7,843,000 7,236,000 6,913,000  4,573,000 4,386,000 3,868,000  1,642,000 1,485,000 1,382,000  871,000 973,000 867,000  782,000 786,000 797,000  574,000 738,000 608,000 527,000 424,000 871,000 
          changes in operating assets and liabilities:
        		                                               
          cash, cash equivalents and restricted cash at beginning of the period
        		 0 0 46,283,000  0 0 57,047,000  0 0 76,560,000  0 0 148,810,000  0 0 182,574,000 0 0 0 100,041,000 0 0 0 190,741,000 0 0 0 89,074,000 0 0              
          cash, cash equivalents and restricted cash at end of the period
        		 -627,000 -3,671,000 55,147,000  -3,958,000 -84,405,000 136,499,000  -13,468,000 4,732,000 57,247,000  26,818,000 -9,466,000 79,968,000  52,526,000 -29,759,000 121,640,000 -181,783,000 -83,944,000 349,708,000 98,593,000 -149,774,000 178,153,000 -111,598,000 183,260,000 7,267,000 147,085,000 3,355,000 33,034,000 45,721,000 12,168,000              
          accrued issuance costs included in additional paid-in-capital
        		       558,000                                        
          amortization of collaboration contract costs
        		                                               
          grant income from ft516 cirm award
        		                                               
          amortization of collaboration contract assets
        		         0 0 7,196,000  783,000 -331,000 1,094,000  1,106,000 979,000 623,000  616,000                          
          right-of-use assets obtained in exchange for lease obligations
        		                                               
          grant income from 2018 cirm award
        		                                               
          amortization of collaboration contract asset
        		                       168,000 187,000 162,000 164,000 107,000                    
          grant income from cirm award
        		        0 0 0 -4,000,000                                    
          right-of use assets obtained in exchange for lease obligations
        		         0    164,000    0 102,000 1,444,000  -127,000 418,000 47,808,000                        
          proceeds from private placement of common stock, net of issuance costs
        		                    -25,000 0                          
          proceeds from sale of common stock to collaboration partner, net of issuance costs
        		                    0 0                          
          proceeds from cirm award
        		                    50,000 0 0 440,000     1,370,000 1,140,000                  
          proceeds from public offering of common stock and issuance of pre-funded warrants, net of issuance costs
        		                   432,445,000                            
          amortization of debt discounts and debt issuance costs
        		                        68,000 15,000 17,000 15,000 19,000 19,000 19,000 19,000 19,000 19,000 19,000 24,000 28,000 33,000 38,000 40,000        
          principal repayments of long–term debt
        		                                               
          supplemental disclosure of cash flow information
        		                                               
          interest paid
        		                        1,353,000 312,000 317,000 309,000                    
          noncash interest expense
        		                         79,000 80,000 79,000 94,000 94,000 93,000 92,000 94,000 89,000 61,000 77,000 96,000 112,000 127,000 157,000 157,000 165,000 165,000 164,000 59,000 7,000 10,000 
          deferred rent
        		                            55,000 66,000 2,000 69,000 269,000 268,000 276,000 272,000 1,000 2,000 -3,000 -7,000        
          issuance of common stock for license agreement
        		                                               
          principal repayments of long-term debt
        		                                               
          issuance on common stock for license agreement
        		                                               
          non-cash loss on extinguishment of debt
        		                                               
          cash payments included in loss on extinguishment of debt
        		                                               
          issuance of common stock from equity incentive plans, net of repurchases and issuance costs
        		                                         221,000      
          proceeds from private placement issuances of common stock, net of issuance costs
        		                                               
          proceeds from private placement issuance of preferred stock, net of issuance costs
        		                                               
          proceeds from long–term debt
        		                                               
          payments of debt issuance costs
        		                                               
          payments included in loss on extinguishment of debt
        		                                               
          issuance of warrants for common stock in connection with long–term debt
        		                                               
          purchases of short-term investments
        		                         0   0 0 0 -55,660,000 0 0 0 -39,971,000 0 -3,509,000 0 -16,166,000        
          maturities of short-term investments
        		                         37,550,000 16,000,000 10,500,000 17,500,000 14,000,000 14,000,000 12,000,000 14,000,000 14,000,000 1,750,000 1,750,000 6,000,000 4,000,000          
          amortization of premiums and discounts on investments
        		                          -298,000 -5,000 -36,000 -87,000 -137,000 -75,000 -4,000 -7,000 -13,000 -1,000 13,000 41,000 62,000 55,000        
          issuance costs from public offering of common stock
        		                              -19,000 -251,000                
          cash flows from operating activities
        		                                               
          issuance of common stock for license agreements
        		                            0                   
          cash flows from investing activities
        		                                               
          purchase of property and equipment
        		                            -1,117,000 -724,000 -278,000 -184,000 -797,000 -362,000 -411,000 -155,000 -40,000 -33,000 -206,000 -178,000        
          cash flows from financing activities
        		                                               
          proceeds from public offerings of common stock, net of issuance costs
        		                            -245,000                   
          payments on long–term debt
        		                                               
          prepaid expenses and other current assets
        		                             -222,000 -500,000 164,000  23,000 289,000 75,000  383,000 -190,000 -112,000  -87,000 72,000 303,000 164,000 52,000 304,000 
          issuance costs from private placement of common stock
        		                                 0 0 -65,000            
          issuance costs from private placement of preferred stock
        		                                 0 0 -128,000            
          proceeds from long-term debt
        		                                               
          payments on long-term debt
        		                                 -6,709,000 -2,044,000 -2,011,000  -1,938,000 -1,903,000 -1,873,000        
          net cash provided (used) by financing activities
        		                              1,156,000 355,000                
          loss on extinguishment of debt
        		                                0               
          proceeds from sale of common stock to collaboration partner
        		                                        0 0      
          payments for the issuance of debt
        		                                               
          proceeds from private placement issuance of common stock, net of issuance costs
        		                                               
          net change in cash and cash equivalents
        		                                   -48,001,000 51,510,000 1,229,000 -3,617,000 -25,322,000 -8,048,000 -8,319,000      
          cash and cash equivalents at beginning of the period
        		                                   88,609,000 0 0 0 64,809,000 0 0 0 49,101,000 0 0 54,036,000 
          cash and cash equivalents at end of the period
        		                                   40,608,000 51,510,000 1,229,000 -3,617,000 39,487,000 -8,048,000 -8,319,000 38,827,000 42,349,000 3,518,000 -5,869,000 47,881,000 
          stock–based milestone charges and change in fair value of exchangeable shares
        		                                               
          issuances of common stock for technology
        		                                               
          amortization of discounts
        		                                             6,000 8,000 
          change in fair value of preferred stock warrants
        		                                               
          loss on disposal of assets
        		                                               
          issuance of common stock, net of repurchases and issuance cost
        		                                               
          issuance of convertible promissory notes
        		                                               
          payment on convertible promissory note
        		                                               
          beneficial conversion feature related to convertible notes
        		                                               
          conversion of convertible preferred stock into common stock
        		                                               
          conversion of convertible notes into common stock
        		                                               
          exchange of exchangeable shares into common stock
        		                                               
          warrant liability reclassification to equity
        		                                               
          amortization of discounts and debt issuance costs
        		                                         45,000 43,000 44,000    
          stock-based milestone charges
        		                                               
          net income
        		                                          -7,779,000 -7,881,000    
          adjustments to reconcile net income to net cash from operating activities:
        		                                               
          stock-based milestone charges and change in fair value of exchangeable shares
        		                                            0 0 375,000 
          issuance of common stock, net of repurchases and issuance costs
        		                                           75,000 2,000   
          adjustments to reconcile net loss to net cash used in operating activities:
        		                                               
          proceeds from (cost of) initial public offering, net of offering costs
        		                                               
          net cash (used in) provided by financing activities
        		                                               
          restricted cash
        		                                               
          repurchase of common stock for cash
        		                                               
          proceeds from initial public offering, net of offering costs
        		                                               
          issuance of preferred stock for cash, net of offering costs
        		                                               
          consolidated net loss
        		                                               
          initial fair value and change in fair value of exchangeable shares
        		                                               
          issuance of common stock, net of repurchases
        		                                               
          costs paid in connection with initial public offering
        		                                               
          proceeds from convertible promissory notes
        		                                               
          issuance of convertible preferred stock, net of offering costs
        		                                               
          net cash provided by financing activities