Exelixis, Inc(NASDAQ:EXEL) 
Exelixis, Inc., an oncology-focused biotechnology company, focuses on the discovery, development, and commercialization of new medicines to treat cancers in the United States. The company's products include CABOMETYX tablets for the treatment of patients with advanced renal cell carcinoma who receiv...
Website: http://www.exelixis.com
Founded: 1994
Full Time Employees: 617
Sector: Healthcare
Industry: Biotechnology
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| Unit: USD | 2026-01-02 | 2025-10-03 | 2025-09-30 | 2025-07-04 | 2025-06-30 | 2025-04-04 | 2025-03-31 | 2025-01-03 | 2024-12-31 | 2024-09-30 | 2024-09-27 | 2024-06-30 | 2024-06-28 | 2024-03-31 | 2024-03-29 | 2023-12-31 | 2023-12-29 | 2023-09-30 | 2023-09-29 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-12-30 | 2022-09-30 | 2022-07-01 | 2022-06-30 | 2022-04-01 | 2022-03-31 | 2021-12-31 | 2021-10-01 | 2021-09-30 | 2021-07-02 | 2021-06-30 | 2021-04-02 | 2021-03-31 | 2021-01-01 | 2020-12-31 | 2020-10-02 | 2020-09-30 | 2020-07-03 | 2020-06-30 | 2020-04-03 | 2020-03-31 | 2020-01-03 | 2019-12-31 | 2019-09-30 | 2019-09-27 | 2019-06-30 | 2019-06-28 | 2019-03-31 | 2019-03-29 | 2018-12-31 | 2018-12-28 | 2018-09-30 | 2018-09-28 | 2018-06-30 | 2018-06-29 | 2018-03-31 | 2018-03-30 | 2017-12-31 | 2017-12-29 | 2017-09-30 | 2017-09-29 | 2017-06-30 | 2017-03-31 | 2016-12-31 | 2016-12-30 | 2016-09-30 | 2016-07-01 | 2016-06-30 | 2016-04-01 | 2016-03-31 | 2016-01-01 | 2015-12-31 | 2015-10-02 | 2015-09-30 | 2015-07-03 | 2015-06-30 | 2015-04-03 | 2015-03-31 | 2014-12-31 | 2014-09-30 | 2014-06-30 | 2014-06-27 | 2014-03-31 | 2014-03-28 | 2013-12-31 | 2013-09-30 | 2013-09-27 | 2013-06-30 | 2013-06-28 | 2013-03-31 | 2013-03-29 | 2012-12-31 | 2012-12-28 | 2012-09-30 | 2012-06-30 | 2012-06-29 | 2012-03-31 | 2012-03-30 | 2011-12-31 | 2011-12-30 | 2011-09-30 | 2011-07-01 | 2011-06-30 | 2011-04-01 | 2011-03-31 | 2010-12-31 | 2010-10-01 | 2010-09-30 | 2010-07-02 | 2010-06-30 | 2010-04-02 | 2010-03-31 | 2010-01-01 | 2009-12-31 | 2009-10-02 | 2009-09-30 | 2009-07-03 | 2009-06-30 | 2009-04-03 | 2009-03-31 | 2009-01-02 | 2008-12-31 | 2008-09-30 | 2008-09-26 | 2008-06-30 | 2008-06-27 | 2008-03-31 | 2008-03-28 | 2007-12-31 | 2007-12-28 | 2007-09-30 | 2007-09-28 | 2007-06-30 | 2007-06-29 | 2007-03-31 | 2007-03-30 | 2006-12-31 | 2006-12-29 | 2006-09-30 | 2006-06-30 | 2006-03-31 | 2005-12-31 | 2005-09-30 | 2005-06-30 | 2005-03-31 | 2004-12-31 | 2004-09-30 | 2004-06-30 | 2004-03-31 | 2003-12-31 | 2003-09-30 | 2003-06-30 |
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assets | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current assets: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents | 482,488,000 | 376,300,000 | 376,300,000 | 164,433,000 | 164,433,000 | 183,752,000 | 183,752,000 | 217,374,000 | 217,374,000 | 258,346,000 | 258,346,000 | 198,459,000 | 198,459,000 | 259,561,000 | 259,561,000 | 262,994,000 | 262,994,000 | 396,859,000 | 396,859,000 | 464,480,000 | 540,597,000 | 501,195,000 | 501,195,000 | 675,286,000 | 627,000,000 | 627,000,000 | 723,269,000 | 723,269,000 | 647,169,000 | 567,325,000 | 567,325,000 | 492,462,000 | 492,462,000 | 370,209,000 | 370,209,000 | 319,217,000 | 319,217,000 | 334,046,000 | 334,046,000 | 527,143,000 | 527,143,000 | 357,340,000 | 357,340,000 | 266,501,000 | 266,501,000 | 242,317,000 | 242,317,000 | 369,789,000 | 369,789,000 | 373,937,000 | 373,937,000 | 314,775,000 | 314,775,000 | 353,623,000 | 353,623,000 | 248,407,000 | 248,407,000 | 232,331,000 | 232,331,000 | 183,164,000 | 183,164,000 | 149,357,000 | 149,357,000 | 135,212,000 | 183,179,000 | 151,686,000 | 151,686,000 | 111,219,000 | 129,827,000 | 129,827,000 | 276,882,000 | 276,882,000 | 141,634,000 | 141,634,000 | 145,642,000 | 145,642,000 | 61,949,000 | 61,949,000 | 84,987,000 | 84,987,000 | 80,395,000 | 100,065,000 | 147,340,000 | 147,340,000 | 157,539,000 | 157,539,000 | 103,978,000 | 92,016,000 | 92,016,000 | 131,774,000 | 131,774,000 | 171,232,000 | 171,232,000 | 170,069,000 | 170,069,000 | 308,805,000 | 68,140,000 | 68,140,000 | 70,466,000 | 70,466,000 | 74,257,000 | 74,257,000 | 66,211,000 | 75,280,000 | 75,280,000 | 202,051,000 | 202,051,000 | 97,440,000 | 95,342,000 | 95,342,000 | 157,202,000 | 157,202,000 | 58,292,000 | 58,292,000 | 86,796,000 | 86,796,000 | 170,570,000 | 170,570,000 | 152,912,000 | 152,912,000 | 201,425,000 | 201,425,000 | 247,698,000 | 247,698,000 | 64,230,000 | 64,230,000 | 75,047,000 | 75,047,000 | 121,883,000 | 121,883,000 | 135,457,000 | 135,457,000 | 141,326,000 | 141,326,000 | 105,607,000 | 105,607,000 | 143,839,000 | 143,839,000 | 123,369,000 | 123,369,000 | 55,700,000 | 86,017,000 | 140,101,000 | 96,471,000 | 90,010,000 | 104,821,000 | 61,384,000 | 78,105,000 | 47,993,000 | 38,924,000 | 80,323,000 | 55,056,000 | 68,572,000 | |
marketable securities | 576,603,000 | 612,235,000 | 612,235,000 | 626,665,000 | 626,665,000 | 847,564,000 | 847,564,000 | 893,902,000 | 893,902,000 | 930,815,000 | 930,815,000 | 163,542,000 | 138,901,000 | 138,901,000 | 172,979,000 | 172,979,000 | 120,005,000 | 120,005,000 | 156,947,000 | 187,502,000 | 187,502,000 | 99,621,000 | 99,621,000 | 65,224,000 | 71,929,000 | 71,929,000 | 55,593,000 | 55,593,000 | 94,243,000 | 94,243,000 | 116,290,000 | 116,290,000 | 115,737,000 | 115,737,000 | 42,993,000 | 42,993,000 | 4,044,000 | 4,044,000 | 26,159,000 | 26,159,000 | 61,634,000 | 61,634,000 | 79,509,000 | 79,509,000 | 105,153,000 | 105,153,000 | 95,965,000 | 95,965,000 | 78,236,000 | 78,236,000 | 83,636,000 | 83,636,000 | 55,516,000 | 55,516,000 | 15,965,000 | 30,145,000 | 36,995,000 | 67,307,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
trade receivables | 286,916,000 | 309,725,000 | 309,725,000 | 292,354,000 | 292,354,000 | 281,637,000 | 281,637,000 | 265,437,000 | 265,437,000 | 269,706,000 | 269,706,000 | 396,584,000 | 396,584,000 | 240,577,000 | 240,577,000 | 237,407,000 | 237,407,000 | 248,113,000 | 248,113,000 | 232,818,000 | 233,923,000 | 214,784,000 | 214,784,000 | 215,015,000 | 235,400,000 | 235,400,000 | 190,614,000 | 190,614,000 | 282,650,000 | 179,493,000 | 179,493,000 | 171,753,000 | 171,753,000 | 177,673,000 | 177,673,000 | 160,875,000 | 160,875,000 | 166,138,000 | 166,138,000 | 121,080,000 | 121,080,000 | 137,338,000 | 137,338,000 | 119,073,000 | 119,073,000 | 169,788,000 | 169,788,000 | 97,541,000 | 97,541,000 | 107,670,000 | 107,670,000 | 162,771,000 | 162,771,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
inventory | 21,686,000 | 27,402,000 | 27,402,000 | 23,483,000 | 23,483,000 | 24,853,000 | 24,853,000 | 22,388,000 | 22,388,000 | 21,013,000 | 21,013,000 | 20,614,000 | 20,614,000 | 21,106,000 | 21,106,000 | 17,323,000 | 17,323,000 | 24,978,000 | 24,978,000 | 28,635,000 | 29,908,000 | 33,299,000 | 33,299,000 | 26,711,000 | 33,020,000 | 33,020,000 | 28,467,000 | 28,467,000 | 27,493,000 | 28,240,000 | 28,240,000 | 24,982,000 | 24,982,000 | 24,757,000 | 24,757,000 | 20,973,000 | 20,973,000 | 19,319,000 | 19,319,000 | 16,608,000 | 16,608,000 | 15,417,000 | 15,417,000 | 12,886,000 | 12,886,000 | 13,366,000 | 13,366,000 | 12,352,000 | 12,352,000 | 10,143,000 | 10,143,000 | 9,838,000 | 9,838,000 | 10,433,000 | 10,433,000 | 8,371,000 | 8,371,000 | 7,563,000 | 7,563,000 | 6,657,000 | 6,657,000 | 5,806,000 | 5,806,000 | 5,425,000 | 3,304,000 | 3,338,000 | 3,338,000 | 3,292,000 | 2,808,000 | 2,808,000 | 2,472,000 | 2,472,000 | 2,616,000 | 2,616,000 | 2,121,000 | 2,121,000 | 2,608,000 | 2,608,000 | 2,593,000 | 2,593,000 | 2,381,000 | 3,876,000 | 3,026,000 | 3,026,000 | 2,686,000 | 2,686,000 | 2,890,000 | 1,764,000 | 1,764,000 | 681,000 | 681,000 | 280,000 | 280,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
prepaid expenses and other current assets | 75,596,000 | 76,595,000 | 76,595,000 | 73,829,000 | 73,829,000 | 58,696,000 | 58,696,000 | 68,478,000 | 68,478,000 | 69,838,000 | 69,838,000 | 58,247,000 | 58,247,000 | 67,490,000 | 67,490,000 | 67,926,000 | 67,926,000 | 66,891,000 | 66,891,000 | 62,259,000 | 60,654,000 | 62,211,000 | 62,211,000 | 52,903,000 | 48,281,000 | 48,281,000 | 53,333,000 | 53,333,000 | 57,530,000 | 51,564,000 | 51,564,000 | 49,878,000 | 49,878,000 | 46,341,000 | 46,341,000 | 57,011,000 | 57,011,000 | 34,470,000 | 34,470,000 | 43,937,000 | 43,937,000 | 29,773,000 | 29,773,000 | 26,988,000 | 26,988,000 | 14,490,000 | 14,490,000 | 12,847,000 | 12,847,000 | 14,146,000 | 14,146,000 | 15,017,000 | 15,017,000 | 12,279,000 | 12,279,000 | 10,327,000 | 10,327,000 | 6,850,000 | 6,850,000 | 8,750,000 | 8,750,000 | 8,012,000 | 8,012,000 | 4,433,000 | 6,297,000 | 5,416,000 | 5,416,000 | 7,148,000 | 4,657,000 | 4,657,000 | 4,791,000 | 4,791,000 | 3,806,000 | 3,806,000 | 3,949,000 | 3,949,000 | 2,731,000 | 2,731,000 | 5,212,000 | 5,212,000 | 3,481,000 | 7,860,000 | 4,792,000 | 4,792,000 | 5,386,000 | 5,386,000 | 5,112,000 | 7,799,000 | 7,799,000 | 5,880,000 | 5,880,000 | 11,030,000 | 11,030,000 | 6,104,000 | 6,104,000 | 6,098,000 | 4,498,000 | 4,498,000 | 4,641,000 | 4,641,000 | 4,372,000 | 4,372,000 | 17,062,000 | 14,555,000 | 14,555,000 | 16,766,000 | 16,766,000 | 14,926,000 | 17,635,000 | 17,635,000 | 16,025,000 | 16,025,000 | 18,000,000 | 18,000,000 | 15,050,000 | 15,050,000 | 10,621,000 | 10,621,000 | 8,882,000 | 8,882,000 | 8,453,000 | 8,453,000 | 7,713,000 | 7,713,000 | 6,760,000 | 6,760,000 | 8,201,000 | 8,201,000 | 7,689,000 | 7,689,000 | 6,151,000 | 6,151,000 | 9,755,000 | 9,755,000 | 9,478,000 | 9,478,000 | 6,997,000 | 6,997,000 | 6,082,000 | 6,082,000 | 7,502,000 | 6,152,000 | 4,951,000 | 5,442,000 | 4,350,000 | |||||||||
total current assets | 1,443,289,000 | 1,402,257,000 | 1,402,257,000 | 1,180,764,000 | 1,180,764,000 | 1,396,502,000 | 1,396,502,000 | 1,467,579,000 | 1,467,579,000 | 1,549,718,000 | 1,549,718,000 | 1,477,444,000 | 1,477,444,000 | 1,292,429,000 | 1,292,429,000 | 1,317,958,000 | 1,317,958,000 | 1,443,369,000 | 1,443,369,000 | 1,590,527,000 | 1,637,618,000 | 1,618,762,000 | 1,618,762,000 | 1,841,621,000 | 1,851,639,000 | 1,851,639,000 | 1,842,743,000 | 1,842,743,000 | 1,834,747,000 | 1,662,028,000 | 1,662,028,000 | 1,593,246,000 | 1,593,246,000 | 1,434,265,000 | 1,434,265,000 | 1,445,395,000 | 1,445,395,000 | 1,407,808,000 | 1,407,808,000 | 1,394,663,000 | 1,394,663,000 | 1,136,896,000 | 1,136,896,000 | 1,011,190,000 | 1,011,190,000 | 972,112,000 | 972,112,000 | 957,247,000 | 957,247,000 | 946,298,000 | 946,298,000 | 897,016,000 | 897,016,000 | 786,962,000 | 786,962,000 | 686,286,000 | 686,286,000 | 565,680,000 | 565,680,000 | 484,874,000 | 484,874,000 | 470,921,000 | 470,921,000 | 402,239,000 | 467,950,000 | 470,803,000 | 470,803,000 | 421,328,000 | 353,383,000 | 353,383,000 | 339,468,000 | 339,468,000 | 178,665,000 | 178,665,000 | 207,351,000 | 207,351,000 | 91,803,000 | 91,803,000 | 125,040,000 | 125,040,000 | 167,241,000 | 220,670,000 | 258,583,000 | 258,583,000 | 298,309,000 | 298,309,000 | 266,609,000 | 306,164,000 | 306,164,000 | 374,956,000 | 374,956,000 | 383,945,000 | 383,945,000 | 432,541,000 | 432,541,000 | 493,395,000 | 213,823,000 | 213,823,000 | 250,016,000 | 250,016,000 | 228,824,000 | 228,824,000 | 244,874,000 | 283,700,000 | 283,700,000 | 324,209,000 | 324,209,000 | 183,486,000 | 192,212,000 | 192,212,000 | 234,848,000 | 234,848,000 | 177,625,000 | 177,625,000 | 230,000,000 | 230,000,000 | 306,522,000 | 306,522,000 | 213,647,000 | 213,647,000 | 230,215,000 | 230,215,000 | 271,571,000 | 271,571,000 | 117,442,000 | 117,442,000 | 173,762,000 | 173,762,000 | 245,844,000 | 245,844,000 | 283,783,000 | 283,783,000 | 294,033,000 | 294,033,000 | 240,885,000 | 240,885,000 | 289,236,000 | 289,236,000 | 262,251,000 | 262,251,000 | 142,418,000 | 188,741,000 | 218,262,000 | 210,361,000 | 214,293,000 | 197,911,000 | 141,963,000 | 163,957,000 | 142,466,000 | 170,239,000 | 209,210,000 | 207,361,000 | 234,943,000 | |
non-current marketable securities | 603,603,000 | 578,287,000 | 578,287,000 | 594,652,000 | 594,652,000 | 619,441,000 | 619,441,000 | 637,291,000 | 637,291,000 | 523,421,000 | 523,421,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
property and equipment | 98,960,000 | 104,748,000 | 104,748,000 | 110,314,000 | 110,314,000 | 115,030,000 | 115,030,000 | 119,391,000 | 119,391,000 | 124,414,000 | 124,414,000 | 130,210,000 | 130,210,000 | 127,222,000 | 127,222,000 | 128,731,000 | 128,731,000 | 121,039,000 | 121,039,000 | 115,004,000 | 116,212,000 | 110,624,000 | 110,624,000 | 107,909,000 | 108,529,000 | 108,529,000 | 106,169,000 | 106,169,000 | 104,031,000 | 99,838,000 | 99,838,000 | 95,133,000 | 95,133,000 | 78,453,000 | 78,453,000 | 67,384,000 | 67,384,000 | 56,385,000 | 56,385,000 | 52,323,000 | 52,323,000 | 48,489,000 | 48,489,000 | 48,892,000 | 48,892,000 | 49,467,000 | 49,467,000 | 50,709,000 | 50,709,000 | 50,553,000 | 50,553,000 | 50,897,000 | 50,897,000 | 51,046,000 | 51,046,000 | 64,744,000 | 64,744,000 | 45,412,000 | 45,412,000 | 25,743,000 | 25,743,000 | 19,256,000 | 19,256,000 | 18,684,000 | 2,594,000 | 2,071,000 | 2,071,000 | 1,737,000 | 1,982,000 | 1,982,000 | 1,813,000 | 1,813,000 | 1,434,000 | 1,434,000 | 1,448,000 | 1,448,000 | 1,812,000 | 1,812,000 | 2,158,000 | 2,158,000 | 2,432,000 | 2,928,000 | 4,052,000 | 4,052,000 | 4,685,000 | 4,685,000 | 4,910,000 | 5,520,000 | 5,520,000 | 5,650,000 | 5,650,000 | 5,786,000 | 5,786,000 | 6,059,000 | 6,059,000 | 6,292,000 | 6,439,000 | 6,439,000 | 7,326,000 | 7,326,000 | 8,506,000 | 8,506,000 | 10,196,000 | 11,903,000 | 11,903,000 | 13,605,000 | 13,605,000 | 15,811,000 | 18,776,000 | 18,776,000 | 20,923,000 | 20,923,000 | 24,379,000 | 24,379,000 | 29,392,000 | 29,392,000 | 28,481,000 | 28,481,000 | 30,696,000 | 30,696,000 | 33,354,000 | 33,354,000 | 36,247,000 | 36,247,000 | 38,683,000 | 38,683,000 | 39,417,000 | 39,417,000 | 35,825,000 | 35,825,000 | 34,664,000 | 34,664,000 | 36,266,000 | 36,266,000 | 34,621,000 | 34,621,000 | 32,451,000 | 32,451,000 | 32,294,000 | 32,294,000 | 33,344,000 | 33,769,000 | 33,715,000 | 35,577,000 | 36,144,000 | 36,965,000 | 36,065,000 | 35,463,000 | 33,795,000 | 33,794,000 | 32,077,000 | 34,622,000 | 35,282,000 | |
deferred tax assets | 292,582,000 | 418,582,000 | 418,582,000 | 419,241,000 | 419,241,000 | 419,045,000 | 419,045,000 | 420,027,000 | 420,027,000 | 358,869,000 | 358,869,000 | 361,561,000 | 361,561,000 | 361,578,000 | 361,578,000 | 361,145,000 | 361,145,000 | 230,990,000 | 230,990,000 | 231,115,000 | 229,603,000 | 231,110,000 | 231,110,000 | 116,415,000 | 113,958,000 | 113,958,000 | 98,001,000 | 98,001,000 | 111,663,000 | 125,295,000 | 125,295,000 | 134,667,000 | 134,667,000 | 160,598,000 | 160,598,000 | 156,711,000 | 156,711,000 | 155,678,000 | 155,678,000 | 148,235,000 | 148,235,000 | 163,187,000 | 163,187,000 | 172,374,000 | 172,374,000 | 186,836,000 | 186,836,000 | 210,237,000 | 210,237,000 | 243,717,000 | 243,717,000 | 244,111,000 | 244,111,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
goodwill | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 63,684,000 | 65,999,000 | 65,999,000 | 67,364,000 | 67,364,000 | 67,364,000 | 67,364,000 | 67,364,000 | 67,364,000 | 67,364,000 | 67,364,000 | 67,364,000 | 67,364,000 | 67,364,000 | 67,364,000 | 67,364,000 | 67,364,000 | 67,364,000 | 67,364,000 | 67,364,000 | 67,364,000 | 67,364,000 | |
right-of-use assets and other non-current assets | 342,305,000 | 255,989,000 | 255,989,000 | 309,426,000 | 309,426,000 | 223,545,000 | 223,545,000 | 239,718,000 | 239,718,000 | 340,170,000 | 340,170,000 | 307,917,000 | 307,917,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total assets | 2,844,423,000 | 2,823,547,000 | 2,823,547,000 | 2,678,081,000 | 2,678,081,000 | 2,837,247,000 | 2,837,247,000 | 2,947,690,000 | 2,947,690,000 | 2,960,276,000 | 2,960,276,000 | 2,773,121,000 | 2,773,121,000 | 2,803,752,000 | 2,803,752,000 | 2,942,357,000 | 2,942,357,000 | 2,976,910,000 | 2,976,910,000 | 3,142,468,000 | 3,143,359,000 | 3,071,489,000 | 3,071,489,000 | 2,961,372,000 | 2,881,404,000 | 2,881,404,000 | 2,654,118,000 | 2,654,118,000 | 2,616,239,000 | 2,447,741,000 | 2,447,741,000 | 2,367,271,000 | 2,367,271,000 | 2,190,542,000 | 2,190,542,000 | 2,137,333,000 | 2,137,333,000 | 2,111,043,000 | 2,111,043,000 | 2,046,548,000 | 2,046,548,000 | 1,955,604,000 | 1,955,604,000 | 1,885,670,000 | 1,885,670,000 | 1,784,865,000 | 1,784,865,000 | 1,643,098,000 | 1,643,098,000 | 1,541,794,000 | 1,541,794,000 | 1,422,286,000 | 1,422,286,000 | 1,024,366,000 | 1,024,366,000 | 911,158,000 | 911,158,000 | 774,915,000 | 774,915,000 | 655,294,000 | 655,294,000 | 609,772,000 | 609,772,000 | 516,532,000 | 586,980,000 | 597,541,000 | 597,541,000 | 548,490,000 | 477,136,000 | 477,136,000 | 492,533,000 | 492,533,000 | 332,342,000 | 332,342,000 | 363,241,000 | 363,241,000 | 248,778,000 | 248,778,000 | 282,934,000 | 282,934,000 | 327,960,000 | 383,656,000 | 440,635,000 | 440,635,000 | 497,565,000 | 497,565,000 | 503,287,000 | 555,959,000 | 555,959,000 | 612,084,000 | 612,084,000 | 659,527,000 | 659,527,000 | 721,097,000 | 721,097,000 | 762,613,000 | 374,488,000 | 374,488,000 | 412,600,000 | 412,600,000 | 393,262,000 | 393,262,000 | 411,636,000 | 454,182,000 | 454,182,000 | 495,736,000 | 495,736,000 | 360,790,000 | 372,906,000 | 372,906,000 | 419,725,000 | 419,725,000 | 284,220,000 | 284,220,000 | 343,410,000 | 343,410,000 | 421,102,000 | 421,102,000 | 333,177,000 | 333,177,000 | 355,105,000 | 355,105,000 | 401,622,000 | 401,622,000 | 254,763,000 | 254,763,000 | 316,621,000 | 316,621,000 | 370,572,000 | 370,572,000 | 412,120,000 | 412,120,000 | 420,291,000 | 420,291,000 | 371,788,000 | 371,788,000 | 420,631,000 | 420,631,000 | 395,417,000 | 395,417,000 | 270,657,000 | 306,477,000 | 337,582,000 | 332,712,000 | 338,706,000 | 325,145,000 | 269,753,000 | 291,340,000 | 267,869,000 | 287,193,000 | 321,657,000 | 336,824,000 | 359,230,000 | |
liabilities and stockholders’ equity | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current liabilities: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts payable | 29,623,000 | 25,348,000 | 25,348,000 | 25,821,000 | 25,821,000 | 42,840,000 | 42,840,000 | 38,191,000 | 38,191,000 | 59,309,000 | 59,309,000 | 28,676,000 | 28,676,000 | 26,069,000 | 26,069,000 | 33,768,000 | 33,768,000 | 26,450,000 | 26,450,000 | 25,994,000 | 32,621,000 | 32,667,000 | 32,667,000 | 30,572,000 | 19,978,000 | 19,978,000 | 17,285,000 | 17,285,000 | 24,258,000 | 24,314,000 | 24,314,000 | 20,450,000 | 20,450,000 | 13,821,000 | 13,821,000 | 23,632,000 | 23,632,000 | 47,927,000 | 47,927,000 | 9,103,000 | 9,103,000 | 15,321,000 | 15,321,000 | 11,581,000 | 11,581,000 | 8,352,000 | 8,352,000 | 12,274,000 | 12,274,000 | 9,748,000 | 9,748,000 | 10,901,000 | 10,901,000 | 8,679,000 | 8,679,000 | 13,023,000 | 13,023,000 | 11,078,000 | 11,078,000 | 9,575,000 | 9,575,000 | 5,988,000 | 5,988,000 | 7,037,000 | 4,649,000 | 6,565,000 | 6,565,000 | 3,965,000 | 5,435,000 | 5,435,000 | 5,657,000 | 5,657,000 | 6,401,000 | 6,401,000 | 2,256,000 | 2,256,000 | 3,398,000 | 3,398,000 | 1,303,000 | 1,303,000 | 6,413,000 | 3,362,000 | 4,638,000 | 4,638,000 | 4,943,000 | 4,943,000 | 9,345,000 | 3,559,000 | 3,559,000 | 3,458,000 | 3,458,000 | 3,498,000 | 3,498,000 | 4,398,000 | 4,398,000 | 3,246,000 | 2,931,000 | 2,931,000 | 1,878,000 | 1,878,000 | 1,957,000 | 1,957,000 | 3,390,000 | 2,298,000 | 2,298,000 | 2,945,000 | 2,945,000 | 2,046,000 | 2,906,000 | 2,906,000 | 3,343,000 | 3,343,000 | 3,577,000 | 3,577,000 | 7,403,000 | 7,403,000 | 4,048,000 | 4,048,000 | 7,904,000 | 7,904,000 | 4,570,000 | 4,570,000 | 4,946,000 | 4,946,000 | 7,342,000 | 7,342,000 | 6,928,000 | 6,928,000 | 9,198,000 | 9,198,000 | 9,288,000 | 9,288,000 | 5,041,000 | 5,041,000 | 5,004,000 | 5,004,000 | 5,433,000 | 5,433,000 | 3,699,000 | 3,699,000 | 2,755,000 | 3,095,000 | 3,120,000 | 1,689,000 | 2,065,000 | 3,565,000 | 2,204,000 | 5,931,000 | 1,622,000 | 1,811,000 | 2,938,000 | 1,592,000 | 3,304,000 | |
accrued compensation and benefits | 102,218,000 | 104,364,000 | 104,364,000 | 72,250,000 | 72,250,000 | 89,747,000 | 89,747,000 | 109,830,000 | 109,830,000 | 90,605,000 | 90,605,000 | 71,806,000 | 71,806,000 | 72,958,000 | 72,958,000 | 93,325,000 | 93,325,000 | 81,398,000 | 81,398,000 | 68,213,000 | 56,551,000 | 77,158,000 | 77,158,000 | 66,927,000 | 61,450,000 | 61,450,000 | 42,768,000 | 42,768,000 | 61,969,000 | 53,306,000 | 53,306,000 | 48,324,000 | 48,324,000 | 37,945,000 | 37,945,000 | 51,189,000 | 51,189,000 | 40,782,000 | 40,782,000 | 33,156,000 | 33,156,000 | 26,687,000 | 26,687,000 | 37,364,000 | 37,364,000 | 31,713,000 | 31,713,000 | 24,144,000 | 24,144,000 | 22,550,000 | 22,550,000 | 32,142,000 | 32,142,000 | 27,283,000 | 27,283,000 | 21,538,000 | 21,538,000 | 20,756,000 | 20,756,000 | 21,073,000 | 21,073,000 | 19,914,000 | 19,914,000 | 15,555,000 | 14,490,000 | 20,334,000 | 20,334,000 | 15,986,000 | 10,307,000 | 10,307,000 | 6,042,000 | 6,042,000 | 3,629,000 | 3,629,000 | 3,725,000 | 3,725,000 | 3,249,000 | 3,249,000 | 3,459,000 | 3,459,000 | 3,350,000 | 6,441,000 | 9,856,000 | 9,856,000 | 8,088,000 | 8,088,000 | 12,797,000 | 9,342,000 | 9,342,000 | 8,127,000 | 8,127,000 | 6,500,000 | 6,500,000 | 10,375,000 | 10,375,000 | 8,255,000 | 7,914,000 | 7,914,000 | 6,586,000 | 6,586,000 | 8,943,000 | 8,943,000 | 8,835,000 | 8,159,000 | 8,159,000 | 6,888,000 | 6,888,000 | 12,078,000 | 12,069,000 | 12,069,000 | 11,459,000 | 11,459,000 | 20,500,000 | 20,500,000 | 16,677,000 | 16,677,000 | 15,215,000 | 15,215,000 | 13,910,000 | 13,910,000 | 11,383,000 | 11,383,000 | 16,142,000 | 16,142,000 | 17,828,000 | 17,828,000 | 13,093,000 | 13,093,000 | 13,303,000 | 13,303,000 | 14,480,000 | 14,480,000 | 14,610,000 | 14,610,000 | 10,580,000 | 10,580,000 | 10,880,000 | 10,880,000 | 11,456,000 | 11,456,000 | 10,781,000 | 7,004,000 | 6,791,000 | 7,817,000 | 7,236,000 | 5,449,000 | 4,950,000 | 6,297,000 | 6,330,000 | 5,049,000 | 4,914,000 | 5,743,000 | 4,379,000 | |
accrued clinical trial liabilities | 65,742,000 | 57,781,000 | 57,781,000 | 57,874,000 | 57,874,000 | 57,635,000 | 57,635,000 | 57,976,000 | 57,976,000 | 56,184,000 | 56,184,000 | 64,829,000 | 64,829,000 | 59,337,000 | 59,337,000 | 71,615,000 | 71,615,000 | 62,842,000 | 62,842,000 | 59,260,000 | 64,210,000 | 65,072,000 | 65,072,000 | 62,057,000 | 76,740,000 | 76,740,000 | 82,885,000 | 82,885,000 | 77,544,000 | 70,618,000 | 70,618,000 | 67,075,000 | 67,075,000 | 59,762,000 | 59,762,000 | 52,251,000 | 52,251,000 | 47,074,000 | 47,074,000 | 39,940,000 | 39,940,000 | 34,969,000 | 34,969,000 | 38,777,000 | 38,777,000 | 30,330,000 | 30,330,000 | 23,709,000 | 23,709,000 | 23,055,000 | 23,055,000 | 18,231,000 | 18,231,000 | 18,958,000 | 18,958,000 | 16,801,000 | 16,801,000 | 15,351,000 | 15,351,000 | 19,849,000 | 19,849,000 | 16,181,000 | 16,181,000 | 14,680,000 | 14,478,000 | 14,131,000 | 14,131,000 | 14,887,000 | 15,681,000 | 15,681,000 | 16,135,000 | 16,135,000 | 18,071,000 | 18,071,000 | 29,788,000 | 29,788,000 | 32,572,000 | 32,572,000 | 30,976,000 | 30,976,000 | 41,545,000 | 45,102,000 | 41,367,000 | 41,367,000 | 39,118,000 | 39,118,000 | 34,958,000 | 35,042,000 | 35,042,000 | 29,406,000 | 29,406,000 | 21,263,000 | 21,263,000 | 20,560,000 | 20,560,000 | 23,701,000 | 23,982,000 | 23,982,000 | 21,634,000 | 21,634,000 | 21,729,000 | 21,729,000 | 24,957,000 | 28,761,000 | 28,761,000 | 31,681,000 | 31,681,000 | 30,975,000 | 30,060,000 | 30,060,000 | 29,200,000 | 29,200,000 | 27,713,000 | 27,713,000 | 24,000,000 | 24,000,000 | 18,982,000 | 18,982,000 | 15,140,000 | 15,140,000 | 20,752,000 | 20,752,000 | 22,551,000 | 22,551,000 | 26,674,000 | 26,674,000 | 25,280,000 | 25,280,000 | 24,101,000 | 24,101,000 | 21,651,000 | 21,651,000 | 19,554,000 | 19,554,000 | 17,811,000 | 17,811,000 | 15,866,000 | 15,866,000 | 12,209,000 | 12,209,000 | ||||||||||||||
rebates and fees due to customers | 59,896,000 | 58,234,000 | 58,234,000 | 57,276,000 | 57,276,000 | 57,840,000 | 57,840,000 | 62,376,000 | 62,376,000 | 62,495,000 | 62,495,000 | 58,468,000 | 58,468,000 | 75,651,000 | 75,651,000 | 59,619,000 | 59,619,000 | 54,374,000 | 54,374,000 | 52,486,000 | 66,405,000 | 50,350,000 | 50,350,000 | 43,791,000 | 43,795,000 | 43,795,000 | 49,997,000 | 49,997,000 | 33,700,000 | 31,120,000 | 31,120,000 | 31,197,000 | 31,197,000 | 31,468,000 | 31,468,000 | 20,683,000 | 20,683,000 | 19,129,000 | 19,129,000 | 16,957,000 | 16,957,000 | 23,006,000 | 23,006,000 | 18,719,000 | 18,719,000 | 16,782,000 | 16,782,000 | 17,273,000 | 17,273,000 | 19,708,000 | 19,708,000 | 14,954,000 | 14,954,000 | 11,689,000 | 11,689,000 | 11,143,000 | 11,143,000 | 11,989,000 | 11,989,000 | 7,565,000 | 7,565,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accrued collaboration liabilities | 22,783,000 | 23,428,000 | 23,428,000 | 21,525,000 | 21,525,000 | 25,489,000 | 25,489,000 | 40,384,000 | 40,384,000 | 30,030,000 | 30,030,000 | 18,683,000 | 18,683,000 | 34,704,000 | 34,704,000 | 27,533,000 | 27,533,000 | 27,269,000 | 27,269,000 | 22,960,000 | 18,324,000 | 20,188,000 | 20,188,000 | 18,277,000 | 29,990,000 | 29,990,000 | 32,492,000 | 32,492,000 | 86,753,000 | 35,403,000 | 35,403,000 | 24,428,000 | 24,428,000 | 13,461,000 | 13,461,000 | 12,456,000 | 12,456,000 | 11,102,000 | 11,102,000 | 10,695,000 | 10,695,000 | 8,663,000 | 8,663,000 | 11,856,000 | 11,856,000 | 7,973,000 | 7,973,000 | 7,847,000 | 7,847,000 | 7,556,000 | 7,556,000 | 7,419,000 | 7,419,000 | 8,397,000 | 8,397,000 | 7,713,000 | 7,713,000 | 7,974,000 | 7,974,000 | 8,974,000 | 8,974,000 | 9,137,000 | 9,137,000 | 7,919,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other current liabilities | 125,382,000 | 104,622,000 | 104,622,000 | 101,365,000 | 101,365,000 | 125,551,000 | 125,551,000 | 95,012,000 | 95,012,000 | 95,723,000 | 95,723,000 | 103,241,000 | 103,241,000 | 104,291,000 | 104,291,000 | 108,417,000 | 108,417,000 | 124,483,000 | 124,483,000 | 110,704,000 | 89,486,000 | 78,924,000 | 78,924,000 | 80,109,000 | 72,568,000 | 72,568,000 | 63,652,000 | 63,652,000 | 53,366,000 | 54,747,000 | 54,747,000 | 63,852,000 | 63,852,000 | 56,880,000 | 56,880,000 | 44,447,000 | 44,447,000 | 35,329,000 | 35,329,000 | 32,830,000 | 32,830,000 | 31,831,000 | 31,831,000 | 24,449,000 | 24,449,000 | 45,919,000 | 45,919,000 | 25,228,000 | 25,228,000 | 40,139,000 | 40,139,000 | 21,825,000 | 21,825,000 | 15,900,000 | 15,900,000 | 23,787,000 | 23,787,000 | 17,711,000 | 17,711,000 | 16,150,000 | 16,150,000 | 26,356,000 | 26,356,000 | 21,225,000 | 24,659,000 | 20,771,000 | 20,771,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total current liabilities | 405,644,000 | 373,777,000 | 373,777,000 | 336,111,000 | 336,111,000 | 399,102,000 | 399,102,000 | 403,769,000 | 403,769,000 | 394,346,000 | 394,346,000 | 345,703,000 | 345,703,000 | 373,010,000 | 373,010,000 | 394,277,000 | 394,277,000 | 376,816,000 | 376,816,000 | 339,617,000 | 327,597,000 | 324,359,000 | 324,359,000 | 301,733,000 | 304,521,000 | 304,521,000 | 289,079,000 | 289,079,000 | 337,590,000 | 269,508,000 | 269,508,000 | 255,326,000 | 255,326,000 | 213,337,000 | 213,337,000 | 204,658,000 | 204,658,000 | 201,343,000 | 201,343,000 | 142,681,000 | 142,681,000 | 140,477,000 | 140,477,000 | 142,746,000 | 142,746,000 | 141,069,000 | 141,069,000 | 110,796,000 | 110,796,000 | 125,132,000 | 125,132,000 | 105,472,000 | 105,472,000 | 90,906,000 | 90,906,000 | 99,944,000 | 99,944,000 | 84,859,000 | 84,859,000 | 115,170,000 | 115,170,000 | 108,953,000 | 108,953,000 | 97,671,000 | 202,287,000 | 270,588,000 | 270,588,000 | 201,643,000 | 192,795,000 | 192,795,000 | 101,067,000 | 101,067,000 | 52,251,000 | 52,251,000 | 55,922,000 | 55,922,000 | 60,316,000 | 60,316,000 | 58,680,000 | 58,680,000 | 171,860,000 | 173,912,000 | 171,857,000 | 171,857,000 | 71,056,000 | 71,056,000 | 87,853,000 | 77,880,000 | 77,880,000 | 74,600,000 | 74,600,000 | 67,799,000 | 67,799,000 | 81,704,000 | 81,704,000 | 85,415,000 | 90,147,000 | 90,147,000 | 87,459,000 | 87,459,000 | 92,325,000 | 92,325,000 | 166,615,000 | 193,542,000 | 193,542,000 | 198,123,000 | 198,123,000 | 199,941,000 | 203,969,000 | 203,969,000 | 222,015,000 | 222,015,000 | 210,344,000 | 210,344,000 | 207,118,000 | 207,118,000 | 214,995,000 | 214,995,000 | 184,474,000 | 184,474,000 | 176,458,000 | 176,458,000 | 189,543,000 | 189,543,000 | 118,882,000 | 118,882,000 | 134,142,000 | 134,142,000 | 132,781,000 | 132,781,000 | 132,885,000 | 132,885,000 | 120,491,000 | 120,491,000 | 115,821,000 | 115,821,000 | 125,822,000 | 125,822,000 | 111,437,000 | 111,437,000 | 82,331,000 | 86,470,000 | 124,319,000 | 108,755,000 | 88,693,000 | 91,893,000 | 67,981,000 | 63,796,000 | 42,168,000 | 40,565,000 | 47,814,000 | 44,487,000 | 50,598,000 | |
non-current operating lease liabilities | 173,038,000 | 176,463,000 | 176,463,000 | 179,842,000 | 179,842,000 | 187,125,000 | 187,125,000 | 190,823,000 | 190,823,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other non-current liabilities | 104,422,000 | 112,607,000 | 112,607,000 | 128,592,000 | 128,592,000 | 119,996,000 | 119,996,000 | 108,895,000 | 108,895,000 | 96,066,000 | 96,066,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total liabilities | 683,104,000 | 662,847,000 | 662,847,000 | 644,545,000 | 644,545,000 | 706,223,000 | 706,223,000 | 703,487,000 | 703,487,000 | 684,857,000 | 684,857,000 | 653,387,000 | 653,387,000 | 675,744,000 | 675,744,000 | 678,445,000 | 678,445,000 | 629,290,000 | 629,290,000 | 614,530,000 | 588,223,000 | 583,062,000 | 583,062,000 | 469,970,000 | 490,144,000 | 490,144,000 | 360,267,000 | 360,267,000 | 405,624,000 | 335,294,000 | 335,294,000 | 324,194,000 | 324,194,000 | 279,355,000 | 279,355,000 | 258,220,000 | 258,220,000 | 259,012,000 | 259,012,000 | 213,224,000 | 213,224,000 | 207,952,000 | 207,952,000 | 199,700,000 | 199,700,000 | 181,148,000 | 181,148,000 | 154,466,000 | 154,466,000 | 156,774,000 | 156,774,000 | 134,833,000 | 134,833,000 | 108,400,000 | 108,400,000 | 136,190,000 | 136,190,000 | 105,149,000 | 105,149,000 | 370,333,000 | 370,333,000 | 371,057,000 | 371,057,000 | 368,021,000 | 467,230,000 | 508,223,000 | 508,223,000 | 516,468,000 | 663,270,000 | 663,270,000 | 648,487,000 | 648,487,000 | 436,646,000 | 436,646,000 | 437,469,000 | 437,469,000 | 436,966,000 | 436,966,000 | 429,693,000 | 429,693,000 | 442,789,000 | 442,167,000 | 437,392,000 | 437,392,000 | 426,083,000 | 426,083,000 | 437,049,000 | 423,196,000 | 423,196,000 | 415,752,000 | 415,752,000 | 404,675,000 | 404,675,000 | 424,663,000 | 424,663,000 | 421,768,000 | 275,439,000 | 275,439,000 | 280,251,000 | 280,251,000 | 302,630,000 | 302,630,000 | 408,582,000 | 535,997,000 | 535,997,000 | 564,485,000 | 564,485,000 | 589,115,000 | 590,499,000 | 590,499,000 | 634,419,000 | 634,419,000 | 483,505,000 | 483,505,000 | 507,135,000 | 507,135,000 | 563,872,000 | 563,872,000 | 456,796,000 | 456,796,000 | 444,053,000 | 444,053,000 | 457,883,000 | 457,883,000 | 278,211,000 | 278,211,000 | 304,563,000 | 304,563,000 | 321,178,000 | 321,178,000 | 326,609,000 | 326,609,000 | 319,657,000 | 319,657,000 | 327,982,000 | 327,982,000 | 351,160,000 | 351,160,000 | 304,806,000 | 304,806,000 | 245,321,000 | 255,013,000 | 303,060,000 | 275,417,000 | 254,158,000 | 262,931,000 | 236,645,000 | 240,669,000 | 187,202,000 | 180,077,000 | 187,010,000 | 153,373,000 | 158,766,000 | |
commitments and contingencies | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stockholders’ equity: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.001 par value... | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
common stock, 0.001 par value... | 262,000 | 268,000 | 268,000 | 270,000 | 270,000 | 275,000 | 275,000 | 282,000 | 282,000 | 286,000 | 286,000 | 285,000 | 285,000 | 295,000 | 295,000 | 303,000 | 303,000 | 311,000 | 311,000 | 320,000 | 325,000 | 324,000 | 324,000 | 323,000 | 322,000 | 322,000 | 320,000 | 320,000 | 319,000 | 316,000 | 316,000 | 315,000 | 315,000 | 313,000 | 313,000 | 312,000 | 312,000 | 309,000 | 309,000 | 309,000 | 309,000 | 306,000 | 306,000 | 305,000 | 305,000 | 304,000 | 304,000 | 303,000 | 303,000 | 302,000 | 302,000 | 300,000 | 300,000 | 299,000 | 299,000 | 298,000 | 298,000 | 297,000 | 297,000 | 296,000 | 296,000 | 296,000 | 296,000 | 294,000 | 292,000 | 290,000 | 290,000 | 286,000 | 230,000 | 230,000 | 228,000 | 228,000 | 228,000 | 228,000 | 225,000 | 225,000 | 196,000 | 196,000 | 196,000 | 196,000 | 196,000 | 195,000 | 195,000 | 195,000 | 194,000 | 194,000 | 184,000 | 184,000 | 184,000 | 184,000 | 184,000 | 184,000 | 184,000 | 183,000 | 183,000 | 109,000 | 108,000 | 108,000 | 106,000 | 106,000 | 105,000 | 105,000 | 96,000 | 96,000 | 84,000 | 75,000 | ||||||||||||||||||||||||||||||||||||||||||||||||
additional paid-in-capital | 2,234,411,000 | 2,262,928,000 | 2,262,928,000 | 2,251,456,000 | 2,251,456,000 | 2,292,033,000 | 2,292,033,000 | 2,343,915,000 | 2,343,915,000 | 1,542,489,000 | 1,267,890,000 | 1,267,890,000 | 1,264,659,000 | 1,264,659,000 | 1,196,992,000 | 1,196,992,000 | 1,155,827,000 | 1,148,588,000 | 1,148,588,000 | 1,140,700,000 | 1,140,700,000 | 953,608,000 | 946,469,000 | 946,469,000 | 940,765,000 | 940,765,000 | 933,481,000 | 933,481,000 | 925,736,000 | 925,736,000 | 917,916,000 | 917,916,000 | 911,699,000 | 911,699,000 | 903,069,000 | 903,069,000 | 897,423,000 | 897,423,000 | 889,313,000 | 889,313,000 | 883,208,000 | 883,208,000 | 871,443,000 | 871,443,000 | 863,127,000 | 863,127,000 | 855,403,000 | 855,403,000 | 776,617,000 | 776,617,000 | 766,282,000 | 766,282,000 | 756,568,000 | 756,568,000 | 659,198,000 | 654,761,000 | 644,096,000 | 636,263,000 | 634,264,000 | 584,045,000 | 579,284,000 | 569,345,000 | 547,251,000 | 546,569,000 | 543,922,000 | 541,276,000 | 532,913,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accumulated other comprehensive income | 3,476,000 | 3,565,000 | 3,565,000 | 1,349,000 | 1,349,000 | 2,010,000 | 2,010,000 | 3,956,000 | 3,956,000 | -758,000 | 1,481,000 | 1,481,000 | 1,985,000 | 1,985,000 | 2,740,000 | 2,740,000 | 4,476,000 | 4,476,000 | 6,239,000 | 6,239,000 | 7,840,000 | 7,840,000 | -222,000 | -222,000 | 3,069,000 | 3,069,000 | 2,668,000 | 2,668,000 | 2,207,000 | 2,207,000 | 728,000 | 728,000 | 129,000 | 129,000 | -121,000 | 24,000 | 177,000 | 177,000 | 153,000 | 153,000 | 146,000 | 180,000 | 180,000 | 102,000 | 102,000 | -18,000 | 5,000 | 5,000 | 50,000 | 50,000 | -138,000 | -138,000 | -249,000 | -13,000 | -13,000 | -32,000 | -32,000 | 12,000 | 18,000 | 18,000 | 18,000 | 18,000 | 99,000 | 99,000 | 155,000 | 155,000 | 96,000 | 96,000 | 20,000 | 20,000 | 3,000 | 3,000 | 178,000 | 178,000 | 602,000 | 602,000 | 1,236,000 | 1,236,000 | 499,000 | 499,000 | 1,017,000 | 1,017,000 | 1,102,000 | 1,102,000 | 1,080,000 | 1,080,000 | 1,145,000 | 1,145,000 | 1,207,000 | 1,028,000 | 1,007,000 | 973,000 | 812,000 | 844,000 | 532,000 | 624,000 | 794,000 | 736,000 | 1,624,000 | 1,563,000 | 2,210,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
accumulated deficit | -76,830,000 | -106,061,000 | -106,061,000 | -219,539,000 | -219,539,000 | -163,294,000 | -163,294,000 | -98,647,000 | -98,647,000 | -90,293,000 | -90,293,000 | -199,972,000 | -199,972,000 | -258,948,000 | -258,948,000 | -173,351,000 | -173,351,000 | -126,049,000 | -126,049,000 | -34,225,000 | -34,225,000 | -4,052,000 | -77,262,000 | -77,262,000 | -147,934,000 | -147,934,000 | -216,507,000 | -311,673,000 | -311,673,000 | -349,877,000 | -349,877,000 | -445,969,000 | -445,969,000 | -447,570,000 | -447,570,000 | -475,958,000 | -475,958,000 | -443,918,000 | -443,918,000 | -510,739,000 | -510,739,000 | -559,351,000 | -559,351,000 | -628,094,000 | -628,094,000 | -725,546,000 | -725,546,000 | -804,588,000 | -804,588,000 | -880,363,000 | -880,363,000 | -1,240,452,000 | -1,240,452,000 | -1,367,316,000 | -1,367,316,000 | -1,454,810,000 | -1,454,810,000 | -1,829,172,000 | -1,829,172,000 | -1,867,661,000 | -1,867,661,000 | -1,949,043,000 | -1,966,699,000 | -1,983,147,000 | -1,983,147,000 | -2,018,270,000 | -2,035,403,000 | -2,035,403,000 | -1,998,388,000 | -1,998,388,000 | -1,937,041,000 | -1,937,041,000 | -1,893,400,000 | -1,893,400,000 | -1,845,836,000 | -1,845,836,000 | -1,802,474,000 | -1,802,474,000 | -1,767,304,000 | -1,709,351,000 | -1,646,791,000 | -1,646,791,000 | -1,573,381,000 | -1,573,381,000 | -1,498,762,000 | -1,428,016,000 | -1,428,016,000 | -1,360,892,000 | -1,360,892,000 | -1,298,731,000 | -1,298,731,000 | -1,254,002,000 | -1,254,002,000 | -1,201,809,000 | -1,168,995,000 | -1,168,995,000 | -1,132,508,000 | -1,132,508,000 | -1,106,357,000 | -1,106,357,000 | -1,152,653,000 | -1,230,518,000 | -1,230,518,000 | -1,209,544,000 | -1,209,544,000 | -1,182,054,000 | -1,164,189,000 | -1,164,189,000 | -1,155,586,000 | -1,155,586,000 | -1,132,973,000 | -1,132,973,000 | -1,089,724,000 | -1,089,724,000 | -1,060,889,000 | -1,060,889,000 | -1,035,445,000 | -1,035,445,000 | -990,684,000 | -990,684,000 | -954,504,000 | -954,504,000 | -916,555,000 | -916,555,000 | -878,048,000 | -878,048,000 | -832,924,000 | -832,924,000 | -791,650,000 | -791,650,000 | -771,728,000 | -771,728,000 | -758,032,000 | -758,032,000 | -729,470,000 | -729,470,000 | -705,269,000 | -705,269,000 | -680,087,000 | -654,890,000 | -630,900,000 | -603,777,000 | -579,255,000 | -556,481,000 | -546,784,000 | -519,373,000 | ||||||||
total stockholders’ equity | 2,161,319,000 | 2,160,700,000 | 2,160,700,000 | 2,033,536,000 | 2,033,536,000 | 2,131,024,000 | 2,131,024,000 | 2,244,203,000 | 2,244,203,000 | 2,275,419,000 | 2,275,419,000 | 2,119,734,000 | 2,119,734,000 | 2,128,008,000 | 2,128,008,000 | 2,263,912,000 | 2,263,912,000 | 2,347,620,000 | 2,347,620,000 | 2,488,427,000 | 2,488,427,000 | 2,210,615,000 | 2,112,447,000 | 2,112,447,000 | 2,043,077,000 | 2,043,077,000 | 1,911,187,000 | 1,911,187,000 | 1,879,113,000 | 1,879,113,000 | 1,852,031,000 | 1,852,031,000 | 1,833,324,000 | 1,833,324,000 | 1,747,652,000 | 1,747,652,000 | 1,685,970,000 | 1,685,970,000 | 1,603,717,000 | 1,603,717,000 | 1,488,632,000 | 1,488,632,000 | 1,385,020,000 | 1,385,020,000 | 1,287,453,000 | 1,287,453,000 | 915,966,000 | 915,966,000 | 774,968,000 | 774,968,000 | 669,766,000 | 669,766,000 | 284,961,000 | 284,961,000 | 238,715,000 | 238,715,000 | 148,511,000 | 119,750,000 | 89,318,000 | 89,318,000 | 32,022,000 | 3,243,000 | 3,243,000 | 71,482,000 | 71,482,000 | 66,238,000 | 132,763,000 | 132,763,000 | 196,332,000 | 196,332,000 | 254,852,000 | 254,852,000 | 296,434,000 | 296,434,000 | 340,845,000 | 99,049,000 | 99,049,000 | 132,349,000 | 132,349,000 | 90,632,000 | 90,632,000 | 3,054,000 | -56,975,000 | -56,975,000 | -26,958,000 | -26,958,000 | 5,867,000 | 5,867,000 | 39,860,000 | 39,860,000 | 72,081,000 | 72,081,000 | 84,796,000 | 84,796,000 | 19,784,000 | 19,784,000 | 37,989,000 | 37,989,000 | 52,540,000 | 52,540,000 | -19,598,000 | 984,000 | 14,288,000 | 33,543,000 | 55,905,000 | 28,485,000 | 33,108,000 | 50,671,000 | 80,667,000 | 107,116,000 | 134,647,000 | 183,451,000 | 200,464,000 | |||||||||||||||||||||||||||||||||||||||||
total liabilities and stockholders’ equity | 2,844,423,000 | 2,823,547,000 | 2,823,547,000 | 2,678,081,000 | 2,678,081,000 | 2,837,247,000 | 2,837,247,000 | 2,947,690,000 | 2,947,690,000 | 2,942,357,000 | 2,942,357,000 | 3,071,489,000 | 3,071,489,000 | 2,616,239,000 | 2,447,741,000 | 2,447,741,000 | 2,367,271,000 | 2,367,271,000 | 2,190,542,000 | 2,190,542,000 | 2,137,333,000 | 2,137,333,000 | 2,111,043,000 | 2,111,043,000 | 2,046,548,000 | 2,046,548,000 | 1,955,604,000 | 1,955,604,000 | 1,885,670,000 | 1,885,670,000 | 1,784,865,000 | 1,784,865,000 | 1,643,098,000 | 1,643,098,000 | 1,541,794,000 | 1,541,794,000 | 1,422,286,000 | 1,422,286,000 | 1,024,366,000 | 1,024,366,000 | 911,158,000 | 911,158,000 | 774,915,000 | 774,915,000 | 655,294,000 | 655,294,000 | 609,772,000 | 609,772,000 | 516,532,000 | 586,980,000 | 597,541,000 | 597,541,000 | 548,490,000 | 440,635,000 | 440,635,000 | 497,565,000 | 497,565,000 | 503,287,000 | 555,959,000 | 555,959,000 | 612,084,000 | 612,084,000 | 659,527,000 | 659,527,000 | 721,097,000 | 721,097,000 | 762,613,000 | 374,488,000 | 374,488,000 | 412,600,000 | 412,600,000 | 393,262,000 | 393,262,000 | 411,636,000 | 338,706,000 | 325,145,000 | 269,753,000 | 291,340,000 | 267,869,000 | 287,193,000 | 321,657,000 | 336,824,000 | 359,230,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accumulated other comprehensive loss | -1,347,000 | -1,347,000 | -5,149,000 | -5,149,000 | -5,204,000 | -5,204,000 | -3,750,000 | -3,750,000 | -14,012,000 | -14,012,000 | -14,437,000 | -9,289,000 | -14,521,000 | -14,521,000 | -17,538,000 | -8,917,000 | -8,917,000 | -6,665,000 | -6,665,000 | -701,000 | -701,000 | -513,000 | -513,000 | -731,000 | -731,000 | -887,000 | -887,000 | -347,000 | -347,000 | -52,000 | -52,000 | -119,000 | -326,000 | -416,000 | -416,000 | -80,000 | -42,000 | -42,000 | -232,000 | -232,000 | -41,000 | -41,000 | -174,000 | -174,000 | -61,000 | -61,000 | -263,000 | -263,000 | -92,000 | -92,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
non-current portion of operating lease liabilities | 194,445,000 | 194,445,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stockholders' equity: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
additional paid-in capital | 2,361,470,000 | 2,361,470,000 | 2,324,570,000 | 2,324,570,000 | 2,391,865,000 | 2,391,865,000 | 2,440,710,000 | 2,440,710,000 | 2,487,370,000 | 2,487,370,000 | 2,530,869,000 | 2,558,297,000 | 2,536,849,000 | 2,536,849,000 | 2,512,669,000 | 2,477,117,000 | 2,477,117,000 | 2,448,130,000 | 2,448,130,000 | 2,427,561,000 | 2,422,323,000 | 2,422,323,000 | 2,390,654,000 | 2,390,654,000 | 2,354,103,000 | 2,354,103,000 | 2,321,895,000 | 2,321,895,000 | 2,321,441,000 | 2,321,441,000 | 2,269,093,000 | 2,269,093,000 | 2,258,307,000 | 2,258,307,000 | 2,241,947,000 | 2,241,947,000 | 2,228,839,000 | 2,228,839,000 | 2,211,668,000 | 2,211,668,000 | 2,188,578,000 | 2,188,578,000 | 2,168,217,000 | 2,168,217,000 | 2,156,632,000 | 2,156,632,000 | 2,142,717,000 | 2,142,717,000 | 2,125,166,000 | 2,125,166,000 | 2,114,184,000 | 2,114,184,000 | 2,106,132,000 | 2,106,132,000 | 2,097,379,000 | 2,086,483,000 | 2,072,591,000 | 2,072,591,000 | 2,050,086,000 | 1,848,910,000 | 1,848,910,000 | 1,842,248,000 | 1,842,248,000 | 1,832,741,000 | 1,832,741,000 | 1,818,988,000 | 1,818,988,000 | 1,657,626,000 | 1,657,626,000 | 1,655,580,000 | 1,655,580,000 | 1,652,400,000 | 1,650,621,000 | 1,649,662,000 | 1,649,662,000 | 1,644,516,000 | 1,644,516,000 | 1,564,670,000 | 1,560,415,000 | 1,560,415,000 | 1,557,303,000 | 1,557,303,000 | 1,553,297,000 | 1,553,297,000 | 1,550,345,000 | 1,550,345,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total liabilities and stockholders' equity | 2,960,276,000 | 2,960,276,000 | 2,773,121,000 | 2,773,121,000 | 2,803,752,000 | 2,803,752,000 | 2,976,910,000 | 2,976,910,000 | 3,142,468,000 | 3,143,359,000 | 2,961,372,000 | 2,881,404,000 | 2,881,404,000 | 2,654,118,000 | 2,654,118,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
short-term investments | 803,540,000 | 803,540,000 | 703,695,000 | 703,695,000 | 732,308,000 | 732,308,000 | 706,528,000 | 706,528,000 | 802,335,000 | 772,536,000 | 807,273,000 | 807,273,000 | 871,706,000 | 907,938,000 | 907,938,000 | 847,060,000 | 847,060,000 | 819,905,000 | 835,406,000 | 835,406,000 | 854,171,000 | 854,171,000 | 815,285,000 | 815,285,000 | 887,319,000 | 887,319,000 | 853,835,000 | 853,835,000 | 685,895,000 | 685,895,000 | 597,028,000 | 597,028,000 | 585,742,000 | 585,742,000 | 518,350,000 | 518,350,000 | 452,328,000 | 452,328,000 | 425,713,000 | 425,713,000 | 378,559,000 | 378,559,000 | 281,000,000 | 281,000,000 | 251,516,000 | 251,516,000 | 194,589,000 | 194,589,000 | 204,607,000 | 204,607,000 | 217,741,000 | 217,741,000 | 214,044,000 | 241,094,000 | 268,117,000 | 268,117,000 | 208,462,000 | 198,292,000 | 198,292,000 | 45,235,000 | 45,235,000 | 25,426,000 | 25,426,000 | 52,169,000 | 52,169,000 | 14,648,000 | 14,648,000 | 22,258,000 | 22,258,000 | 63,890,000 | 91,937,000 | 86,177,000 | 86,177,000 | 116,033,000 | 116,033,000 | 138,475,000 | 187,203,000 | 187,203,000 | 220,198,000 | 220,198,000 | 185,332,000 | 185,332,000 | 241,371,000 | 241,371,000 | 72,929,000 | 42,682,000 | 62,189,000 | 77,078,000 | 82,851,000 | 123,722,000 | 121,551,000 | 144,627,000 | 156,774,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term investments | 432,305,000 | 432,305,000 | 629,561,000 | 629,561,000 | 728,717,000 | 728,717,000 | 811,680,000 | 811,680,000 | 838,615,000 | 806,615,000 | 756,731,000 | 756,731,000 | 551,735,000 | 463,889,000 | 463,889,000 | 404,535,000 | 404,535,000 | 371,112,000 | 362,218,000 | 362,218,000 | 345,613,000 | 345,613,000 | 328,860,000 | 328,860,000 | 332,306,000 | 332,306,000 | 358,079,000 | 358,079,000 | 327,141,000 | 327,141,000 | 486,036,000 | 486,036,000 | 536,385,000 | 536,385,000 | 486,763,000 | 486,763,000 | 337,785,000 | 337,785,000 | 218,619,000 | 218,619,000 | 157,187,000 | 157,187,000 | 114,093,000 | 114,093,000 | 94,396,000 | 94,396,000 | 96,710,000 | 96,710,000 | 64,255,000 | 64,255,000 | 50,569,000 | 50,569,000 | 26,413,000 | 47,351,000 | 55,601,000 | 55,601,000 | 55,817,000 | 51,727,000 | 51,727,000 | 82,850,000 | 82,850,000 | 83,600,000 | 83,600,000 | 81,600,000 | 81,600,000 | 81,598,000 | 81,598,000 | 81,597,000 | 81,597,000 | 81,579,000 | 84,589,000 | 95,513,000 | 95,513,000 | 111,155,000 | 111,155,000 | 144,299,000 | 157,402,000 | 157,402,000 | 138,125,000 | 138,125,000 | 176,088,000 | 176,088,000 | 182,311,000 | 182,311,000 | 162,173,000 | 83,678,000 | 83,678,000 | 84,470,000 | 84,470,000 | 85,260,000 | 85,260,000 | 85,787,000 | 86,574,000 | 86,574,000 | 85,825,000 | 85,825,000 | 87,314,000 | 87,295,000 | 87,295,000 | 89,422,000 | 89,422,000 | 9,502,000 | 9,502,000 | 11,463,000 | 11,463,000 | 17,769,000 | 17,769,000 | |||||||||||||||||||||||||||||||||||||||||||||||
long-term portion of operating lease liabilities | 198,017,000 | 198,017,000 | 201,466,000 | 201,466,000 | 189,944,000 | 189,944,000 | 190,858,000 | 190,858,000 | 194,694,000 | 186,948,000 | 190,170,000 | 190,170,000 | 159,838,000 | 161,019,000 | 161,019,000 | 50,636,000 | 50,636,000 | 51,272,000 | 52,252,000 | 52,252,000 | 53,223,000 | 53,223,000 | 52,837,000 | 52,837,000 | 49,086,000 | 49,086,000 | 47,626,000 | 47,626,000 | 48,334,000 | 48,334,000 | 47,883,000 | 47,883,000 | 48,011,000 | 48,011,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other long-term liabilities | 109,667,000 | 109,667,000 | 101,268,000 | 101,268,000 | 94,224,000 | 94,224,000 | 61,616,000 | 61,616,000 | 73,495,000 | 67,379,000 | 61,951,000 | 61,951,000 | 1,908,000 | 17,395,000 | 17,395,000 | 12,517,000 | 12,517,000 | 8,023,000 | 4,090,000 | 4,090,000 | 7,068,000 | 7,068,000 | 3,421,000 | 3,421,000 | 721,000 | 721,000 | 721,000 | 721,000 | 7,206,000 | 7,206,000 | 5,459,000 | 5,459,000 | 2,347,000 | 2,347,000 | 975,000 | 975,000 | 4,495,000 | 4,495,000 | 3,361,000 | 3,361,000 | 1,286,000 | 1,286,000 | 2,607,000 | 2,607,000 | 3,630,000 | 3,630,000 | 17,113,000 | 17,113,000 | 16,643,000 | 16,643,000 | 16,012,000 | 16,012,000 | 16,687,000 | 3,707,000 | 541,000 | 541,000 | 759,000 | 1,082,000 | 1,082,000 | 1,317,000 | 1,317,000 | 1,575,000 | 1,575,000 | 1,881,000 | 1,881,000 | 2,345,000 | 2,345,000 | 2,961,000 | 2,961,000 | 4,169,000 | 4,772,000 | 5,102,000 | 5,102,000 | 5,467,000 | 5,467,000 | 4,674,000 | 5,726,000 | 5,726,000 | 5,882,000 | 5,882,000 | 6,113,000 | 6,113,000 | 6,256,000 | 6,256,000 | 7,768,000 | 7,558,000 | 7,558,000 | 7,755,000 | 7,755,000 | 7,844,000 | 7,844,000 | 8,247,000 | 8,445,000 | 8,445,000 | 8,772,000 | 8,772,000 | 15,992,000 | 23,415,000 | 23,415,000 | 23,606,000 | 23,606,000 | 17,173,000 | 17,173,000 | 17,325,000 | 17,325,000 | 23,907,000 | 23,907,000 | 23,505,000 | 23,505,000 | 23,103,000 | 23,103,000 | 22,620,000 | 22,620,000 | 27,338,000 | 27,338,000 | 26,254,000 | 26,254,000 | 25,755,000 | 25,755,000 | 24,924,000 | 24,924,000 | 24,419,000 | 24,419,000 | 23,255,000 | 23,255,000 | 21,588,000 | 21,588,000 | 20,491,000 | 20,491,000 | 19,180,000 | 17,855,000 | 16,184,000 | 14,475,000 | 12,750,000 | 10,949,000 | 9,788,000 | 7,995,000 | 6,838,000 | 2,515,000 | 1,734,000 | 869,000 | 619,000 | ||||||||||||
right-of-use assets and other | 329,278,000 | 329,278,000 | 342,122,000 | 342,122,000 | 306,148,000 | 306,148,000 | 303,523,000 | 289,627,000 | 290,578,000 | 290,578,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term portion of deferred revenues | 6,724,000 | 6,491,000 | 7,209,000 | 7,209,000 | 8,035,000 | 8,035,000 | 9,444,000 | 9,444,000 | 8,577,000 | 8,577,000 | 9,760,000 | 9,760,000 | 9,322,000 | 9,322,000 | 15,003,000 | 15,003,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
retained earnings | 11,186,000 | 5,803,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total stockholders' equity | 2,527,938,000 | 2,555,136,000 | 2,491,402,000 | 2,391,260,000 | 2,391,260,000 | 2,293,851,000 | 2,293,851,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term portion of deferred revenue | 6,299,000 | 6,582,000 | 6,582,000 | 8,739,000 | 3,755,000 | 3,755,000 | 14,133,000 | 14,133,000 | 6,596,000 | 6,596,000 | 15,399,000 | 15,399,000 | 16,632,000 | 16,632,000 | 8,323,000 | 8,323,000 | 15,897,000 | 15,897,000 | 2,268,000 | 2,268,000 | 11,970,000 | 11,970,000 | 3,177,000 | 3,177,000 | 238,520,000 | 238,520,000 | 246,092,000 | 246,092,000 | 253,663,000 | 261,236,000 | 237,094,000 | 237,094,000 | 232,573,000 | 180,838,000 | 180,838,000 | 184,431,000 | 184,431,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other long-term assets | 280,008,000 | 279,705,000 | 279,705,000 | 138,986,000 | 138,986,000 | 131,002,000 | 134,678,000 | 134,678,000 | 134,928,000 | 134,928,000 | 124,682,000 | 124,682,000 | 71,853,000 | 71,853,000 | 69,409,000 | 69,409,000 | 60,502,000 | 60,502,000 | 57,312,000 | 57,312,000 | 53,145,000 | 53,145,000 | 7,268,000 | 7,268,000 | 5,763,000 | 5,763,000 | 3,902,000 | 3,902,000 | 2,424,000 | 2,424,000 | 1,492,000 | 1,492,000 | 948,000 | 948,000 | 1,929,000 | 1,929,000 | 12,092,000 | 12,092,000 | 692,000 | 692,000 | 862,000 | 1,251,000 | 1,232,000 | 1,232,000 | 1,774,000 | 2,210,000 | 2,210,000 | 2,068,000 | 2,068,000 | 2,309,000 | 2,309,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stockholders' equity | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
commitments | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other receivables | 13,801,000 | 13,801,000 | 12,390,000 | 12,390,000 | 7,445,000 | 7,445,000 | 16,056,000 | 16,056,000 | 2,751,000 | 2,751,000 | 2,708,000 | 2,284,000 | 2,284,000 | 1,930,000 | 1,930,000 | 30,190,000 | 30,190,000 | 4,654,000 | 6,363,000 | 6,363,000 | 5,771,000 | 5,771,000 | 5,896,000 | 7,306,000 | 7,306,000 | 6,028,000 | 6,028,000 | 7,090,000 | 7,090,000 | 11,864,000 | 11,864,000 | 9,594,000 | 9,594,000 | 8,860,000 | 8,860,000 | 3,712,000 | 3,712,000 | 1,457,000 | 1,457,000 | 1,820,000 | 1,820,000 | 6,504,000 | 6,504,000 | 9,190,000 | 9,190,000 | 6,087,000 | 6,087,000 | 8,256,000 | 8,256,000 | 2,855,000 | 2,855,000 | 3,812,000 | 3,812,000 | 22,197,000 | 22,197,000 | 3,511,000 | 1,391,000 | 5,936,000 | 7,102,000 | 6,671,000 | 4,512,000 | 13,142,000 | 4,424,000 | 5,090,000 | 2,477,000 | 3,556,000 | 2,844,000 | 4,145,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term restricted cash and investments | 1,000,000 | 1,000,000 | 1,100,000 | 1,100,000 | 1,100,000 | 1,100,000 | 1,100,000 | 1,100,000 | 1,100,000 | 1,100,000 | 1,100,000 | 1,100,000 | 1,500,000 | 1,500,000 | 4,646,000 | 4,646,000 | 4,650,000 | 4,650,000 | 4,650,000 | 4,150,000 | 4,150,000 | 4,150,000 | 4,150,000 | 4,150,000 | 4,150,000 | 2,650,000 | 2,650,000 | 2,650,000 | 2,650,000 | 2,650,000 | 2,650,000 | 2,684,000 | 2,684,000 | 2,684,000 | 2,684,000 | 4,684,000 | 4,684,000 | 10,781,000 | 10,781,000 | 10,814,000 | 10,814,000 | 16,897,000 | 15,889,000 | 15,889,000 | 21,956,000 | 21,956,000 | 21,899,000 | 21,899,000 | 27,964,000 | 27,964,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
operating lease right-of-use assets | 17,735,000 | 17,735,000 | 16,573,000 | 16,573,000 | 13,921,000 | 13,921,000 | 5,867,000 | 5,867,000 | 5,989,000 | 5,989,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term portion of lease liabilities | 23,705,000 | 23,705,000 | 22,543,000 | 22,543,000 | 19,958,000 | 19,958,000 | 12,178,000 | 12,178,000 | 12,619,000 | 12,619,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of deferred revenue | 321,000 | 321,000 | 2,376,000 | 2,376,000 | 5,939,000 | 5,939,000 | 31,984,000 | 31,984,000 | 31,377,000 | 31,377,000 | 31,255,000 | 30,662,000 | 19,665,000 | 19,665,000 | 18,939,000 | 14,631,000 | 14,631,000 | 14,371,000 | 14,371,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
unbilled collaboration revenue | 7,244,000 | 7,244,000 | 24,489,000 | 24,489,000 | 31,844,000 | 31,844,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
short-term restricted cash and investments | 504,000 | 504,000 | 504,000 | 504,000 | 504,000 | 504,000 | 504,000 | 504,000 | 6,109,000 | 6,109,000 | 6,108,000 | 6,108,000 | 12,212,000 | 12,210,000 | 12,214,000 | 12,214,000 | 12,208,000 | 12,208,000 | 12,213,000 | 12,211,000 | 12,211,000 | 12,214,000 | 12,214,000 | 12,206,000 | 12,206,000 | 12,246,000 | 12,246,000 | 12,242,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
trade and other receivables | 104,634,000 | 104,634,000 | 167,161,000 | 167,161,000 | 91,999,000 | 91,999,000 | 81,192,000 | 81,192,000 | 90,005,000 | 90,005,000 | 43,125,000 | 34,076,000 | 42,246,000 | 42,246,000 | 91,207,000 | 17,799,000 | 17,799,000 | 10,088,000 | 10,088,000 | 5,183,000 | 5,183,000 | 3,470,000 | 3,470,000 | 3,758,000 | 3,758,000 | 3,882,000 | 3,882,000 | 4,882,000 | 4,722,000 | 5,034,000 | 5,034,000 | 4,457,000 | 4,457,000 | 3,941,000 | 5,171,000 | 5,171,000 | 4,209,000 | 4,209,000 | 3,865,000 | 3,865,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
financing obligation for build-to-suit lease | 20,646,000 | 20,646,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible notes | 113,349,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
term loan payable | 80,000,000 | 80,000,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stockholders’ equity | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accrued collaboration liability | 18,710,000 | 16,993,000 | 16,993,000 | 14,674,000 | 14,674,000 | 10,938,000 | 10,938,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of convertible notes | 109,122,000 | 109,122,000 | 29,365,000 | 27,500,000 | 27,500,000 | 27,500,000 | 27,500,000 | 450,000 | 450,000 | 3,911,000 | 3,911,000 | 98,880,000 | 96,496,000 | 94,207,000 | 94,207,000 | 10,000,000 | 10,000,000 | 10,000,000 | 10,000,000 | 10,000,000 | 10,000,000 | 10,000,000 | 10,000,000 | 10,000,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of term loan payable | 80,000,000 | 80,000,000 | 80,000,000 | 80,000,000 | 80,000,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term portion of convertible notes | 81,493,000 | 288,555,000 | 288,555,000 | 281,156,000 | 281,156,000 | 301,435,000 | 301,435,000 | 297,436,000 | 297,436,000 | 291,225,000 | 291,225,000 | 284,355,000 | 284,355,000 | 182,395,000 | 177,962,000 | 173,635,000 | 173,635,000 | 261,408,000 | 261,408,000 | 255,147,000 | 248,707,000 | 248,707,000 | 242,459,000 | 242,459,000 | 236,385,000 | 236,385,000 | 240,476,000 | 240,476,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term portion of term loan payable | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liabilities and stockholders’ deficit | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other accrued liabilities | 19,791,000 | 22,248,000 | 22,248,000 | 13,671,000 | 13,671,000 | 10,007,000 | 10,007,000 | 15,969,000 | 15,969,000 | 15,803,000 | 15,803,000 | 13,867,000 | 13,867,000 | 12,282,000 | 13,855,000 | 15,859,000 | 15,859,000 | 11,974,000 | 11,974,000 | 13,116,000 | 13,017,000 | 13,017,000 | 15,362,000 | 15,362,000 | 10,392,000 | 10,392,000 | 11,795,000 | 11,795,000 | 8,882,000 | 6,425,000 | 6,425,000 | 8,218,000 | 8,218,000 | 8,423,000 | 8,423,000 | 15,195,000 | 15,569,000 | 15,569,000 | 15,993,000 | 15,993,000 | 16,797,000 | 19,625,000 | 19,625,000 | 20,243,000 | 20,243,000 | 18,837,000 | 18,837,000 | 16,399,000 | 16,399,000 | 18,742,000 | 18,742,000 | 15,467,000 | 15,467,000 | 13,915,000 | 13,915,000 | 14,007,000 | 14,007,000 | 7,594,000 | 7,594,000 | 11,499,000 | 11,499,000 | 9,657,000 | 9,657,000 | 7,018,000 | 7,018,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stockholders’ deficit: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total stockholders’ deficit | -186,134,000 | -186,134,000 | -155,954,000 | -155,954,000 | -104,304,000 | -104,304,000 | -74,228,000 | -74,228,000 | -188,188,000 | -188,188,000 | -146,759,000 | -146,759,000 | -81,815,000 | -81,815,000 | -68,749,000 | -68,749,000 | -228,325,000 | -217,593,000 | -217,593,000 | -214,694,000 | -214,694,000 | -199,285,000 | -199,285,000 | -163,725,000 | -163,725,000 | -142,770,000 | -142,770,000 | -123,619,000 | -123,619,000 | -88,948,000 | -88,948,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total liabilities and stockholders’ deficit | 477,136,000 | 477,136,000 | 492,533,000 | 492,533,000 | 332,342,000 | 332,342,000 | 363,241,000 | 363,241,000 | 248,778,000 | 248,778,000 | 282,934,000 | 282,934,000 | 454,182,000 | 454,182,000 | 495,736,000 | 495,736,000 | 360,790,000 | 419,725,000 | 419,725,000 | 284,220,000 | 284,220,000 | 343,410,000 | 343,410,000 | 421,102,000 | 421,102,000 | 333,177,000 | 333,177,000 | 355,105,000 | 355,105,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of restructuring | 3,017,000 | 3,017,000 | 3,205,000 | 3,205,000 | 3,734,000 | 3,734,000 | 5,294,000 | 5,294,000 | 4,993,000 | 4,993,000 | 6,426,000 | 6,580,000 | 3,726,000 | 3,726,000 | 4,298,000 | 4,298,000 | 4,425,000 | 3,776,000 | 3,776,000 | 4,194,000 | 4,194,000 | 4,077,000 | 4,077,000 | 5,085,000 | 5,085,000 | 4,033,000 | 4,484,000 | 4,484,000 | 3,875,000 | 3,875,000 | 4,483,000 | 4,483,000 | 2,725,000 | 2,624,000 | 2,624,000 | 3,850,000 | 3,850,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term portion of restructuring | 516,000 | 516,000 | 1,385,000 | 1,385,000 | 2,230,000 | 2,230,000 | 3,080,000 | 3,080,000 | 3,697,000 | 3,697,000 | 4,365,000 | 5,521,000 | 6,743,000 | 6,743,000 | 7,933,000 | 7,933,000 | 9,047,000 | 10,126,000 | 10,126,000 | 11,679,000 | 11,679,000 | 12,767,000 | 12,767,000 | 14,137,000 | 14,137,000 | 6,456,000 | 7,499,000 | 7,499,000 | 8,481,000 | 8,481,000 | 9,495,000 | 9,495,000 | 7,670,000 | 7,478,000 | 7,478,000 | 8,954,000 | 8,954,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of loans payable | 164,000 | 164,000 | 381,000 | 757,000 | 1,077,000 | 1,077,000 | 1,392,000 | 1,392,000 | 1,762,000 | 2,127,000 | 2,127,000 | 2,546,000 | 2,546,000 | 2,858,000 | 2,858,000 | 3,170,000 | 3,170,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred revenue | 7,000 | 7,000 | 2,583,000 | 1,319,000 | 1,127,000 | 1,127,000 | 1,243,000 | 1,243,000 | 1,450,000 | 1,017,000 | 1,017,000 | 1,507,000 | 1,507,000 | 9,211,000 | 9,211,000 | 16,321,000 | 16,321,000 | 24,134,000 | 31,253,000 | 31,253,000 | 31,253,000 | 31,253,000 | 41,920,000 | 41,920,000 | 76,639,000 | 99,603,000 | 99,603,000 | 99,802,000 | 99,802,000 | 100,297,000 | 102,254,000 | 102,254,000 | 119,948,000 | 119,948,000 | 101,748,000 | 101,748,000 | 103,385,000 | 103,385,000 | 118,499,000 | 118,499,000 | 91,314,000 | 91,314,000 | 83,869,000 | 83,869,000 | 88,936,000 | 88,936,000 | 45,266,000 | 45,266,000 | 63,768,000 | 63,768,000 | 65,675,000 | 65,675,000 | 64,105,000 | 64,105,000 | 57,260,000 | 57,260,000 | 60,141,000 | 60,141,000 | 72,995,000 | 72,995,000 | 63,476,000 | 63,476,000 | 43,655,000 | 51,826,000 | 59,259,000 | 43,484,000 | 27,935,000 | 32,497,000 | 41,994,000 | 28,697,000 | 15,777,000 | 15,251,000 | 20,029,000 | 17,267,000 | 24,184,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term portion of loans payable | 80,000,000 | 80,000,000 | 80,000,000 | 80,000,000 | 80,000,000 | 80,000,000 | 80,000,000 | 80,000,000 | 80,000,000 | 80,000,000 | 80,055,000 | 80,055,000 | 80,219,000 | 80,219,000 | 80,328,000 | 80,757,000 | 80,757,000 | 81,132,000 | 81,132,000 | 81,611,000 | 81,611,000 | 82,090,000 | 82,090,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other assets | 6,508,000 | 6,508,000 | 7,197,000 | 7,197,000 | 7,771,000 | 7,771,000 | 8,340,000 | 7,101,000 | 8,022,000 | 8,022,000 | 8,918,000 | 8,918,000 | 6,888,000 | 7,300,000 | 7,300,000 | 7,713,000 | 7,713,000 | 8,125,000 | 8,125,000 | 8,538,000 | 8,538,000 | 9,123,000 | 2,797,000 | 2,797,000 | 2,905,000 | 2,905,000 | 2,789,000 | 2,789,000 | 2,896,000 | 4,122,000 | 4,122,000 | 4,214,000 | 4,214,000 | 4,096,000 | 4,540,000 | 4,540,000 | 4,449,000 | 4,449,000 | 2,586,000 | 2,586,000 | 2,427,000 | 2,427,000 | 7,695,000 | 7,695,000 | 8,000,000 | 8,000,000 | 8,168,000 | 8,168,000 | 8,336,000 | 8,336,000 | 8,666,000 | 8,666,000 | 8,970,000 | 8,970,000 | 1,947,000 | 1,947,000 | 2,004,000 | 2,004,000 | 2,071,000 | 2,071,000 | 2,003,000 | 2,003,000 | 1,586,000 | 1,586,000 | 1,695,000 | 1,695,000 | 1,838,000 | 2,685,000 | 2,964,000 | 3,303,000 | 3,679,000 | 4,175,000 | 4,617,000 | 3,953,000 | 4,164,000 | 4,304,000 | 3,900,000 | 3,753,000 | 3,984,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liabilities and stockholders’ (deficit) equity | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stockholders’ (deficit) equity: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total stockholders’ (deficit) equity | -114,829,000 | -58,511,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total liabilities and stockholders’ (deficit) equity | 327,960,000 | 383,656,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
* | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
contingencies | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
restricted cash and investments | 27,946,000 | 4,067,000 | 4,067,000 | 4,199,000 | 4,199,000 | 4,199,000 | 4,199,000 | 4,199,000 | 4,199,000 | 4,199,000 | 4,199,000 | 4,199,000 | 6,399,000 | 6,399,000 | 6,399,000 | 6,399,000 | 6,399,000 | 6,444,000 | 6,444,000 | 6,444,000 | 6,444,000 | 4,744,000 | 4,744,000 | 4,744,000 | 4,744,000 | 4,853,000 | 4,853,000 | 4,015,000 | 4,015,000 | 4,854,000 | 4,854,000 | 5,694,000 | 5,694,000 | 5,333,000 | 5,333,000 | 7,238,000 | 7,238,000 | 8,078,000 | 8,078,000 | 8,917,000 | 8,917,000 | 9,908,000 | 9,908,000 | 9,635,000 | 9,635,000 | 11,221,000 | 11,004,000 | 12,123,000 | 12,682,000 | 13,522,000 | 14,753,000 | 15,480,000 | 16,040,000 | 16,390,000 | 7,635,000 | 5,137,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of notes payable and bank obligations | 3,164,000 | 3,158,000 | 3,158,000 | 4,015,000 | 4,015,000 | 4,870,000 | 4,870,000 | 5,974,000 | 7,628,000 | 7,628,000 | 8,064,000 | 8,064,000 | 8,848,000 | 9,005,000 | 9,005,000 | 9,772,000 | 9,772,000 | 9,919,000 | 9,919,000 | 11,204,000 | 11,204,000 | 11,459,000 | 11,459,000 | 12,689,000 | 12,689,000 | 13,919,000 | 13,919,000 | 14,911,000 | 14,911,000 | 16,945,000 | 16,945,000 | 17,770,000 | 17,770,000 | 14,942,000 | 14,942,000 | 15,767,000 | 15,767,000 | 12,527,000 | 12,527,000 | 12,628,000 | 12,628,000 | 13,521,000 | 13,521,000 | 13,579,000 | 13,579,000 | 11,527,000 | 11,544,000 | 12,081,000 | 11,893,000 | 9,691,000 | 9,162,000 | 8,016,000 | 8,928,000 | 7,177,000 | 5,405,000 | 4,658,000 | 4,658,000 | 3,174,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of convertible loans | 10,000,000 | 10,000,000 | 10,000,000 | 10,000,000 | 10,000,000 | 28,900,000 | 28,900,000 | 28,900,000 | 28,900,000 | 28,900,000 | 28,900,000 | 28,050,000 | 28,050,000 | 28,050,000 | 28,050,000 | 28,050,000 | 28,050,000 | 28,050,000 | 28,050,000 | 28,050,000 | 28,050,000 | 28,050,000 | 28,050,000 | 28,050,000 | 28,050,000 | 28,050,000 | 28,050,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term portion of notes payable and bank obligations | 82,885,000 | 83,678,000 | 83,678,000 | 84,470,000 | 84,470,000 | 85,260,000 | 85,260,000 | 85,787,000 | 86,574,000 | 86,574,000 | 85,825,000 | 85,825,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term portion of convertible loans | 239,244,000 | 85,862,000 | 85,862,000 | 83,578,000 | 83,578,000 | 91,385,000 | 91,385,000 | 89,295,000 | 87,288,000 | 87,288,000 | 85,240,000 | 85,240,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
183,489,026 and 135,563,735 shares at september 30, 2012 and december 31, 2011, respectively: | 183,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
148,794,245 and 135,563,735 shares at june 30, 2012 and december 31, 2011, respectively: | 149,000 | 149,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
148,457,650 and 135,563,735 shares at march 31, 2012 and december 31, 2011, respectively: | 148,000 | 148,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
135,563,735 and 109,287,160 shares at december 31, 2011 and 2010, respectively | 135,000 | 135,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
common stock | 129,000 | 128,000 | 128,000 | 127,000 | 127,000 | 109,000 | 109,000 | 109,000 | 109,000 | 108,000 | 108,000 | 107,000 | 107,000 | 107,000 | 107,000 | 106,000 | 106,000 | 106,000 | 106,000 | 105,000 | 105,000 | 105,000 | 105,000 | 104,000 | 104,000 | 97,000 | 97,000 | 97,000 | 97,000 | 84,000 | 85,000 | 85,000 | 84,000 | 77,000 | 76,000 | 73,000 | 73,000 | 72,000 | 72,000 | 71,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
notes payable and bank obligations | 87,314,000 | 89,422,000 | 89,422,000 | 9,502,000 | 9,502,000 | 11,463,000 | 11,463,000 | 9,976,000 | 9,976,000 | 12,406,000 | 12,406,000 | 14,831,000 | 14,831,000 | 17,769,000 | 17,769,000 | 21,433,000 | 21,433,000 | 25,094,000 | 25,094,000 | 17,939,000 | 17,939,000 | 20,747,000 | 20,747,000 | 14,841,000 | 14,841,000 | 17,713,000 | 17,713,000 | 20,633,000 | 20,633,000 | 23,074,000 | 23,074,000 | 15,965,000 | 18,301,000 | 21,250,000 | 21,858,000 | 19,672,000 | 22,380,000 | 18,633,000 | 21,398,000 | 17,791,000 | 13,271,000 | 13,273,000 | 11,834,000 | 8,297,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible loans | 83,396,000 | 108,900,000 | 108,900,000 | 28,900,000 | 28,900,000 | 28,900,000 | 28,900,000 | 56,950,000 | 56,950,000 | 56,950,000 | 56,950,000 | 56,950,000 | 56,950,000 | 56,950,000 | 56,950,000 | 85,000,000 | 85,000,000 | 85,000,000 | 85,000,000 | 85,000,000 | 85,000,000 | 85,000,000 | 85,000,000 | 85,000,000 | 85,000,000 | 85,000,000 | 85,000,000 | 85,000,000 | 85,000,000 | 85,000,000 | 85,000,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liabilities, noncontrolling interest and stockholders’ deficit | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long term portion of notes payable and bank obligations | 87,295,000 | 87,295,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long term portion of convertible loans | 110,561,000 | 110,561,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
exelixis, inc. stockholders’ deficit: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total exelixis, inc. stockholders’ deficit | -217,593,000 | -217,593,000 | -214,694,000 | -214,694,000 | -199,285,000 | -199,285,000 | -163,725,000 | -163,725,000 | -142,770,000 | -142,770,000 | -123,619,000 | -123,619,000 | -87,506,000 | -87,506,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
noncontrolling interest | -1,442,000 | -1,442,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total liabilities, noncontrolling interest, and stockholders’ deficit | 372,906,000 | 372,906,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liabilities, noncontrolling interest and stockholders’ equity | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
investments held by symphony evolution, inc. | 12,581,000 | 12,581,000 | 14,703,000 | 14,703,000 | 18,473,000 | 18,473,000 | 22,376,000 | 22,376,000 | 27,573,000 | 27,573,000 | 30,935,000 | 30,935,000 | 38,731,000 | 38,731,000 | 44,709,000 | 44,709,000 | 50,952,000 | 50,952,000 | 55,087,000 | 55,087,000 | 59,740,000 | 65,036,000 | 30,279,000 | 34,039,000 | 37,542,000 | 40,005,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term marketable securities | 9,976,000 | 9,976,000 | 12,406,000 | 12,406,000 | 14,831,000 | 14,831,000 | 21,434,000 | 21,434,000 | 25,094,000 | 25,094,000 | 17,939,000 | 17,939,000 | 20,747,000 | 20,747,000 | 13,516,000 | 13,516,000 | 15,537,000 | 15,537,000 | 17,553,000 | 17,553,000 | 19,573,000 | 19,573,000 | 11,768,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
noncontrolling interest in symphony evolution, inc. | 714,000 | 714,000 | 3,510,000 | 3,510,000 | 6,191,000 | 6,191,000 | 9,534,000 | 9,534,000 | 13,430,000 | 13,430,000 | 15,838,000 | 15,838,000 | 24,022,000 | 24,022,000 | 31,482,000 | 31,482,000 | 38,071,000 | 38,071,000 | 44,934,000 | 50,480,000 | 20,234,000 | 23,752,000 | 28,643,000 | 33,729,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total liabilities, noncontrolling interest and stockholders’ equity | 401,622,000 | 401,622,000 | 254,763,000 | 254,763,000 | 316,621,000 | 316,621,000 | 370,572,000 | 370,572,000 | 412,120,000 | 412,120,000 | 420,291,000 | 420,291,000 | 371,788,000 | 371,788,000 | 420,631,000 | 420,631,000 | 395,417,000 | 395,417,000 | 270,657,000 | 306,477,000 | 337,582,000 | 332,712,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other accrued expenses | 4,827,000 | 4,827,000 | 7,303,000 | 7,303,000 | 5,562,000 | 5,562,000 | 7,127,000 | 7,127,000 | 13,613,000 | 13,001,000 | 13,060,000 | 13,774,000 | 11,419,000 | 10,489,000 | 9,460,000 | 12,012,000 | 9,085,000 | 10,371,000 | 11,867,000 | 9,675,000 | 9,125,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other intangibles | 328,000 | 328,000 | 2,461,000 | 2,461,000 | 2,533,000 | 2,533,000 | 2,605,000 | 2,605,000 | 2,704,000 | 2,914,000 | 3,154,000 | 3,425,000 | 3,697,000 | 3,968,000 | 4,240,000 | 4,512,000 | 3,690,000 | 3,858,000 | 3,969,000 | 4,302,000 | 4,469,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of capital lease obligations | 8,000 | 98,000 | 347,000 | 731,000 | 1,357,000 | 1,931,000 | 2,177,000 | 2,679,000 | 3,408,000 | 5,552,000 | 6,432,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible promissory note | 30,000,000 | 30,000,000 | 30,000,000 | 30,000,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible promissory loans | 85,000,000 | 85,000,000 | 85,000,000 | 85,000,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible promissory note and loans | 85,000,000 | 85,000,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
capital lease obligations | 8,000 | 98,000 | 297,000 | 627,000 | 1,136,000 | 2,467,000 | 3,307,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
prepaid expense and other current assets | 7,141,000 | 5,891,000 | 5,248,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
related-party receivables | 7,000 | 9,000 | 24,000 | 51,000 | 540,000 | 600,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible promissory note and loan | 115,000,000 | 115,000,000 | 85,000,000 | 85,000,000 | 85,000,000 | 55,000,000 | 55,000,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
notes receivable from stockholders | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred stock compensation | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other current assets | 6,532,000 | 5,116,000 | 3,780,000 | 4,834,000 | 5,452,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
restricted cash | 18,882,000 | 12,588,000 |
Cashflow Statements:
Quarterly
Annual
| Unit: USD | 2026-01-02 | 2025-09-30 | 2025-06-30 | 2025-04-04 | 2025-03-31 | 2024-12-31 | 2024-09-27 | 2024-06-28 | 2024-03-31 | 2024-03-29 | 2023-12-29 | 2023-09-29 | 2023-06-30 | 2023-03-31 | 2022-12-30 | 2022-09-30 | 2022-06-30 | 2022-04-01 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-04-02 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-04-03 | 2020-03-31 | 2019-12-31 | 2019-09-27 | 2019-06-28 | 2019-03-31 | 2019-03-29 | 2018-12-28 | 2018-09-28 | 2018-06-29 | 2018-03-31 | 2018-03-30 | 2017-12-29 | 2017-09-29 | 2017-06-30 | 2017-03-31 | 2016-12-30 | 2016-09-30 | 2016-06-30 | 2016-04-01 | 2016-03-31 | 2015-12-31 | 2015-09-30 | 2015-06-30 | 2015-04-03 | 2015-03-31 | 2014-12-31 | 2014-09-26 | 2014-06-27 | 2014-03-31 | 2014-03-28 | 2013-12-31 | 2013-09-27 | 2013-06-28 | 2013-03-31 | 2013-03-29 | 2012-12-28 | 2012-09-30 | 2012-06-29 | 2012-03-31 | 2012-03-30 | 2011-12-30 | 2011-09-30 | 2011-06-30 | 2011-04-01 | 2011-03-31 | 2010-12-31 | 2010-09-30 | 2010-06-30 | 2010-04-02 | 2010-03-31 | 2009-12-31 | 2009-09-30 | 2009-06-30 | 2009-04-03 | 2009-03-31 | 2008-12-31 | 2008-09-26 | 2008-06-27 | 2008-03-31 | 2008-03-28 | 2007-12-28 | 2007-09-28 | 2007-06-29 | 2007-03-31 | 2007-03-30 | 2006-12-29 | 2006-09-30 | 2006-06-30 | 2006-03-31 | 2005-12-31 | 2005-09-30 | 2005-06-30 | 2005-03-31 | 2004-12-31 | 2004-09-30 | 2004-06-30 | 2004-03-31 | 2003-09-30 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
net income | 244,528,000 | 193,578,000 | 184,848,000 | 159,616,000 | 159,616,000 | 139,861,000 | 117,973,000 | 226,116,000 | 37,317,000 | 37,317,000 | 85,518,000 | 1,041,000 | 81,178,000 | 40,028,000 | -30,173,000 | 73,210,000 | 70,672,000 | 68,573,000 | 68,573,000 | 95,166,000 | 38,204,000 | 96,092,000 | 1,601,000 | 1,601,000 | 28,388,000 | -32,040,000 | 66,821,000 | 48,612,000 | 48,612,000 | 68,743,000 | 97,452,000 | 79,042,000 | 75,775,000 | 75,775,000 | 360,089,000 | 126,630,000 | 87,494,000 | 115,857,000 | 115,857,000 | 38,489,000 | 81,382,000 | 17,656,000 | 16,700,000 | -61,347,000 | -35,170,000 | -74,619,000 | -70,746,000 | -44,729,000 | -52,193,000 | -32,814,000 | -26,151,000 | -27,490,000 | -37,949,000 | -41,274,000 | -24,201,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||
adjustments to reconcile net income to net cash from operating activities: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
depreciation and amortization | 6,946,000 | 7,422,000 | 7,342,000 | 7,345,000 | 7,345,000 | 5,663,000 | 2,090,000 | 2,036,000 | 1,962,000 | 1,962,000 | 2,039,000 | 1,700,000 | 805,000 | 371,000 | 371,000 | 345,000 | 279,000 | 282,000 | 281,000 | 248,000 | 298,000 | 227,000 | 229,000 | 229,000 | 343,000 | 379,000 | 387,000 | 297,000 | 297,000 | -623,000 | 1,921,000 | 595,000 | 498,000 | 498,000 | 765,000 | 754,000 | 786,000 | 842,000 | 842,000 | 1,646,000 | 1,431,000 | 1,407,000 | 1,233,000 | 1,233,000 | 1,787,000 | 1,106,000 | 2,000,000 | 1,929,000 | 1,929,000 | 2,267,000 | 2,403,000 | 2,801,000 | 3,072,000 | 3,072,000 | 3,037,000 | 3,117,000 | 3,155,000 | 3,286,000 | 3,286,000 | 3,405,000 | 3,261,000 | 3,297,000 | 3,264,000 | 3,264,000 | 3,142,000 | 2,847,000 | 2,384,000 | 2,757,000 | 2,757,000 | 3,524,000 | 3,893,000 | 4,360,000 | 4,313,000 | 4,115,000 | 4,298,000 | 4,078,000 | 4,178,000 | 4,173,000 | 3,967,000 | 4,097,000 | 4,478,000 | 4,180,000 | ||||||||||||||||||||||||
impairment of long-lived assets | 153,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stock-based compensation | 20,097,000 | 30,885,000 | 36,071,000 | 25,930,000 | 25,930,000 | 26,346,000 | 23,023,000 | 25,354,000 | 19,113,000 | 19,113,000 | 24,306,000 | 40,478,000 | 24,900,000 | 16,661,000 | 25,856,000 | 37,337,000 | 24,622,000 | 19,759,000 | 19,759,000 | 23,166,000 | 33,966,000 | 28,035,000 | 34,653,000 | 34,653,000 | 19,279,000 | 55,655,000 | 16,154,000 | 13,982,000 | 13,982,000 | 15,855,000 | 13,139,000 | 15,079,000 | 12,529,000 | 12,529,000 | 12,296,000 | 9,742,000 | 9,283,000 | 9,305,000 | 9,305,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
non-cash lease expense | 6,019,000 | 6,044,000 | 6,070,000 | 6,096,000 | 6,096,000 | 6,350,000 | 7,168,000 | 7,179,000 | 6,764,000 | 6,764,000 | 7,501,000 | 7,495,000 | 7,249,000 | 6,731,000 | 6,384,000 | 5,488,000 | 5,058,000 | 1,385,000 | 1,385,000 | 1,380,000 | 1,366,000 | 1,365,000 | 1,221,000 | 1,221,000 | 1,223,000 | 1,224,000 | 1,209,000 | 1,174,000 | 1,174,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred taxes | 15,318,000 | 15,318,000 | 14,164,000 | 9,565,000 | 26,188,000 | -3,388,000 | -3,388,000 | -538,000 | -6,990,000 | 12,665,000 | 10,128,000 | 10,128,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
acquired in-process research and development technology | 5,000,000 | 6,249,000 | 19,500,000 | 11,000,000 | 750,000 | 19,500,000 | 19,500,000 | 0 | 91,000,000 | 1,000,000 | 36,500,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other | -2,348,000 | 1,356,000 | -5,831,000 | -4,786,000 | -4,786,000 | -4,379,000 | -17,171,000 | -1,282,000 | 9,206,000 | 9,206,000 | -4,425,000 | -4,196,000 | -4,433,000 | -3,743,000 | -7,915,000 | 3,031,000 | 2,779,000 | 1,580,000 | 1,580,000 | -12,428,000 | 13,040,000 | 16,253,000 | 6,578,000 | 6,578,000 | 1,426,000 | 883,000 | 1,614,000 | -888,000 | -888,000 | -935,000 | -933,000 | -2,212,000 | 1,722,000 | 1,722,000 | 59,000 | 384,000 | 466,000 | 680,000 | -1,129,000 | -243,000 | 336,000 | -1,474,000 | -1,474,000 | -11,000 | 245,000 | 456,000 | 637,000 | 637,000 | 559,000 | 987,000 | 1,140,000 | 1,475,000 | 1,475,000 | 1,544,000 | 1,601,000 | 1,909,000 | 1,733,000 | 1,733,000 | 1,539,000 | 1,084,000 | 1,062,000 | 1,304,000 | 1,304,000 | 1,164,000 | 1,855,000 | 1,304,000 | 478,000 | 478,000 | 819,000 | 762,000 | 715,000 | 938,000 | 938,000 | 998,000 | 426,000 | -161,000 | 356,000 | 356,000 | -63,000 | 417,000 | 380,000 | 212,000 | 212,000 | 240,000 | 229,000 | 172,000 | 145,000 | 145,000 | 202,000 | 242,000 | 175,000 | 135,000 | 156,000 | 157,000 | 172,000 | 117,000 | 203,000 | 173,000 | -508,000 | 562,000 | 134,000 | |||||
changes in operating assets and liabilities: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
trade receivables | 22,809,000 | -17,370,000 | -10,718,000 | -16,119,000 | -16,119,000 | 127,025,000 | -156,047,000 | -3,170,000 | -3,170,000 | 11,181,000 | -15,487,000 | 861,000 | -19,178,000 | -41,000 | 20,197,000 | -45,100,000 | 91,793,000 | 91,793,000 | -102,200,000 | -7,811,000 | 5,377,000 | -17,690,000 | -17,690,000 | 4,604,000 | -45,060,000 | 16,256,000 | -18,270,000 | -18,270,000 | 50,733,000 | -72,247,000 | 10,129,000 | 55,101,000 | 55,101,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
inventory | 13,806,000 | -4,149,000 | 2,639,000 | -71,000 | -71,000 | 2,762,000 | -384,000 | 1,360,000 | 1,715,000 | 1,715,000 | 1,526,000 | -1,688,000 | -4,445,000 | -8,370,000 | -1,847,000 | -1,514,000 | -4,802,000 | -3,520,000 | -3,520,000 | 13,747,000 | -18,936,000 | -5,930,000 | -2,090,000 | -2,090,000 | -8,431,000 | -6,417,000 | -2,354,000 | -4,695,000 | -4,695,000 | -2,203,000 | -1,014,000 | -2,209,000 | -305,000 | -305,000 | 595,000 | -2,062,000 | -808,000 | -906,000 | -906,000 | -851,000 | -381,000 | -2,121,000 | 34,000 | -46,000 | -484,000 | -336,000 | 144,000 | 144,000 | -494,000 | 486,000 | -15,000 | -212,000 | -212,000 | 1,495,000 | -850,000 | -340,000 | 204,000 | 204,000 | -1,126,000 | -1,083,000 | -401,000 | -280,000 | -280,000 | |||||||||||||||||||||||||||||||||||||||||||
prepaid expenses and other assets | -97,034,000 | 47,649,000 | -104,706,000 | 20,320,000 | 20,320,000 | 94,147,000 | -96,728,000 | 23,585,000 | 10,075,000 | 10,075,000 | -32,254,000 | -6,118,000 | -1,824,000 | 10,372,000 | 6,907,000 | -9,141,000 | -22,420,000 | -3,605,000 | -3,605,000 | -15,623,000 | -11,956,000 | -14,168,000 | 1,872,000 | 1,872,000 | -9,963,000 | 3,086,000 | -16,091,000 | -2,863,000 | -2,863,000 | -1,061,000 | 2,799,000 | -1,846,000 | -1,846,000 | -3,060,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accrued collaboration liabilities | 355,000 | 903,000 | -3,964,000 | 4,605,000 | 4,605,000 | 854,000 | 1,347,000 | 1,479,000 | -3,829,000 | -3,829,000 | 264,000 | -2,191,000 | 5,136,000 | -1,864,000 | 1,911,000 | -11,713,000 | 998,000 | -54,261,000 | -54,261,000 | -261,000 | -1,000,000 | -1,000,000 | -163,000 | 1,218,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts payable and other liabilities | -12,900,000 | 17,755,000 | -63,508,000 | 8,501,000 | 8,501,000 | 2,243,000 | 26,393,000 | -16,275,000 | -34,247,000 | -34,247,000 | 46,777,000 | 192,000 | 5,154,000 | 1,123,000 | 19,127,000 | -11,188,000 | 10,527,000 | 7,376,000 | 7,376,000 | 7,278,000 | 18,977,000 | 28,697,000 | 138,000 | 138,000 | -42,000 | 50,889,000 | 2,393,000 | -2,131,000 | -2,131,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net cash from operating activities | 333,515,000 | 290,322,000 | 48,993,000 | 211,437,000 | 211,437,000 | 240,263,000 | 271,338,000 | 119,548,000 | 68,822,000 | 68,822,000 | 10,571,000 | 117,367,000 | 120,978,000 | 84,408,000 | 73,694,000 | 110,071,000 | 31,130,000 | 147,719,000 | 147,719,000 | 96,452,000 | 83,307,000 | 181,501,000 | 39,544,000 | 39,544,000 | 33,293,000 | 17,938,000 | 101,677,000 | 56,074,000 | 56,074,000 | 158,021,000 | 75,614,000 | 131,728,000 | 161,593,000 | 161,593,000 | 104,591,000 | 164,552,000 | 74,769,000 | 71,808,000 | 71,808,000 | 53,353,000 | 37,865,000 | 5,535,000 | 68,858,000 | 83,714,000 | -6,435,000 | -25,879,000 | 154,896,000 | 154,896,000 | -35,433,000 | -34,233,000 | -26,833,000 | -45,086,000 | -45,086,000 | -49,976,000 | -58,006,000 | -55,337,000 | -72,086,000 | -72,086,000 | -47,329,000 | -56,995,000 | -40,034,000 | -54,415,000 | -54,415,000 | -38,736,000 | -34,053,000 | -35,391,000 | -14,966,000 | -14,966,000 | -29,174,000 | -43,267,000 | -43,516,000 | -43,276,000 | -43,276,000 | 21,254,000 | -43,827,000 | -24,736,000 | -53,739,000 | -53,739,000 | -50,750,000 | 90,706,000 | -12,425,000 | -42,122,000 | -42,122,000 | 153,821,000 | -56,391,000 | -67,969,000 | -39,218,000 | -39,218,000 | -24,914,000 | -39,356,000 | -49,269,000 | 44,800,000 | 44,800,000 | 10,124,000 | -34,251,000 | -31,246,000 | 10,034,000 | -6,177,000 | -32,645,000 | 24,746,000 | -32,285,000 | |||||
capital expenditures | -1,157,000 | -1,482,000 | -2,838,000 | -2,952,000 | -2,952,000 | -3,977,000 | -8,197,000 | -6,570,000 | -9,691,000 | -9,691,000 | -13,135,000 | -9,373,000 | -5,937,000 | -12,024,000 | -1,717,000 | -9,970,000 | -12,337,000 | -5,609,000 | -5,609,000 | -18,364,000 | -14,479,000 | -20,211,000 | -13,557,000 | -13,557,000 | -14,291,000 | -6,091,000 | -6,641,000 | -2,480,000 | -2,480,000 | 0 | -2,059,000 | -1,209,000 | -2,307,000 | -2,307,000 | 0 | -15,221,000 | -12,235,000 | -2,947,000 | -2,947,000 | -17,694,000 | -1,137,000 | -1,504,000 | -808,000 | -587,000 | -33,000 | -401,000 | -682,000 | -682,000 | -333,000 | -20,000 | -63,000 | -31,000 | -31,000 | -22,000 | -108,000 | 40,000 | -384,000 | -384,000 | -92,000 | -677,000 | -673,000 | -729,000 | -729,000 | -1,189,000 | -1,019,000 | -437,000 | -72,000 | -72,000 | -279,000 | -144,000 | -163,000 | -405,000 | -405,000 | -330,000 | -650,000 | -579,000 | -252,000 | -252,000 | -4,316,000 | -750,000 | -444,000 | -398,000 | -398,000 | -1,207,000 | -2,391,000 | -6,171,000 | -5,363,000 | -5,363,000 | -3,249,000 | -4,749,000 | -5,761,000 | -3,640,000 | -3,640,000 | -3,273,000 | -1,540,000 | -4,740,000 | -2,057,000 | -3,238,000 | -2,859,000 | -4,274,000 | -3,986,000 | |||||
free cash flows | 332,358,000 | 288,840,000 | 46,155,000 | 208,485,000 | 208,485,000 | 236,286,000 | 263,141,000 | 112,978,000 | 59,131,000 | 59,131,000 | -2,564,000 | 107,994,000 | 115,041,000 | 72,384,000 | 71,977,000 | 100,101,000 | 18,793,000 | 142,110,000 | 142,110,000 | 78,088,000 | 68,828,000 | 161,290,000 | 25,987,000 | 25,987,000 | 19,002,000 | 11,847,000 | 95,036,000 | 53,594,000 | 53,594,000 | 158,021,000 | 73,555,000 | 130,519,000 | 159,286,000 | 159,286,000 | 104,591,000 | 149,331,000 | 62,534,000 | 68,861,000 | 68,861,000 | 35,659,000 | 36,728,000 | 4,031,000 | 68,050,000 | 83,127,000 | -6,468,000 | -26,280,000 | 154,214,000 | 154,214,000 | -35,766,000 | -34,253,000 | -26,896,000 | -45,117,000 | -45,117,000 | -49,998,000 | -58,114,000 | -55,297,000 | -72,470,000 | -72,470,000 | -47,421,000 | -57,672,000 | -40,707,000 | -55,144,000 | -55,144,000 | -39,925,000 | -35,072,000 | -35,828,000 | -15,038,000 | -15,038,000 | -29,453,000 | -43,411,000 | -43,679,000 | -43,681,000 | -43,681,000 | 20,924,000 | -44,477,000 | -25,315,000 | -53,991,000 | -53,991,000 | -55,066,000 | 89,956,000 | -12,869,000 | -42,520,000 | -42,520,000 | 152,614,000 | -58,782,000 | -74,140,000 | -44,581,000 | -44,581,000 | -28,163,000 | -44,105,000 | -55,030,000 | 41,160,000 | 41,160,000 | 6,851,000 | -35,791,000 | -35,986,000 | 7,977,000 | -9,415,000 | -35,504,000 | 20,472,000 | -36,271,000 | |||||
cash flows from investing activities: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchases of marketable securities | -154,941,000 | -189,370,000 | -101,485,000 | -186,701,000 | -186,701,000 | -305,383,000 | -199,303,000 | -46,853,000 | -113,368,000 | -113,368,000 | -26,633,000 | -21,144,000 | -129,421,000 | -60,015,000 | -60,015,000 | -26,131,000 | -37,623,000 | -80,000,000 | -23,563,000 | -23,563,000 | -39,277,000 | -78,869,000 | -38,972,000 | -4,048,000 | -4,048,000 | 3,665,000 | 3,660,000 | -4,347,000 | -4,932,000 | -4,932,000 | -30,726,000 | -64,897,000 | -46,638,000 | -61,556,000 | -61,556,000 | -55,143,000 | -8,598,000 | -12,821,000 | -15,180,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from maturities and sales of marketable securities | 189,339,000 | 221,506,000 | 353,104,000 | 258,917,000 | 258,917,000 | 226,159,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchases of property, equipment and other | -1,157,000 | -1,482,000 | -2,838,000 | -2,952,000 | -2,952,000 | -3,977,000 | -8,197,000 | -6,570,000 | -9,691,000 | -9,691,000 | -13,135,000 | -9,373,000 | -5,937,000 | -12,024,000 | -1,717,000 | -8,043,000 | -12,337,000 | -5,609,000 | -5,609,000 | -15,960,000 | -14,497,000 | -20,211,000 | -13,557,000 | -13,557,000 | -14,290,000 | -6,130,000 | -6,964,000 | -2,961,000 | -2,961,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net cash from investing activities | 27,241,000 | 25,405,000 | 248,031,000 | 49,764,000 | 49,764,000 | -93,201,000 | -217,147,000 | 81,772,000 | 111,793,000 | 111,793,000 | 61,737,000 | 34,685,000 | -73,785,000 | -49,592,000 | -245,782,000 | -68,951,000 | -135,142,000 | -74,539,000 | -74,539,000 | -13,055,000 | -21,239,000 | -70,845,000 | 62,255,000 | 62,255,000 | -29,509,000 | -207,600,000 | 73,274,000 | 32,620,000 | 32,620,000 | -130,201,000 | -206,460,000 | -142,929,000 | -107,657,000 | -107,657,000 | -142,799,000 | -63,251,000 | -66,267,000 | -25,533,000 | -25,533,000 | -18,833,000 | -26,591,000 | 46,716,000 | 34,503,000 | -60,410,000 | -12,128,000 | -123,825,000 | -19,685,000 | -19,685,000 | 24,009,000 | -31,512,000 | 7,685,000 | 49,895,000 | 49,895,000 | 30,176,000 | 11,105,000 | 44,689,000 | 60,360,000 | 60,360,000 | 59,505,000 | 18,026,000 | 467,000 | 66,353,000 | 66,353,000 | -99,629,000 | -141,206,000 | 33,643,000 | -52,278,000 | -52,278,000 | 37,375,000 | 32,559,000 | -89,895,000 | -31,502,000 | -31,502,000 | 6,394,000 | -15,192,000 | -38,382,000 | 27,611,000 | 27,611,000 | -8,151,000 | -69,391,000 | -34,557,000 | -223,000 | -223,000 | 50,054,000 | 8,720,000 | 29,271,000 | 29,271,000 | 7,122,000 | 4,904,000 | 9,909,000 | -24,954,000 | -24,954,000 | -44,038,000 | 21,257,000 | -31,444,000 | 32,524,000 | 6,738,000 | -29,639,000 | -24,121,000 | 10,953,000 | -179,000 | |||||
cash flows from financing activities: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
payments for repurchases of common stock | -257,618,000 | -104,035,000 | -301,924,000 | -283,934,000 | -283,934,000 | -190,412,000 | -11,927,000 | -264,319,000 | -185,375,000 | -185,375,000 | -209,296,000 | -216,843,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of common stock under the equity incentive plan and stock purchase plan | 7,875,000 | 18,823,000 | 19,789,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
taxes paid related to net share settlement of equity awards | -4,825,000 | -3,377,000 | -40,502,000 | -22,516,000 | -22,516,000 | -16,445,000 | -2,166,000 | -13,026,000 | -6,988,000 | -6,988,000 | -5,986,000 | -9,747,000 | -10,832,000 | -2,557,000 | -7,209,000 | -4,927,000 | -6,478,000 | -4,686,000 | -4,686,000 | -24,059,000 | -5,636,000 | -3,972,000 | -5,441,000 | -5,441,000 | -23,898,000 | -5,179,000 | -19,148,000 | -1,793,000 | -1,793,000 | -6,535,000 | -935,000 | -854,000 | -1,580,000 | -1,580,000 | -4,369,000 | -229,000 | -847,000 | -2,129,000 | -2,129,000 | -3,551,000 | -681,000 | -788,000 | -1,543,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net cash from financing activities | -254,568,000 | -103,860,000 | -316,343,000 | -294,823,000 | -294,823,000 | -188,034,000 | 5,696,000 | -262,422,000 | -184,048,000 | -184,048,000 | -206,173,000 | -219,673,000 | -124,792,000 | 4,586,000 | -2,003,000 | -2,038,000 | 4,422,000 | 205,000 | 205,000 | -17,994,000 | -2,881,000 | 8,724,000 | -2,650,000 | -2,650,000 | -18,694,000 | -3,435,000 | -5,148,000 | 2,145,000 | 2,145,000 | -3,000,000 | 3,274,000 | 7,053,000 | 5,226,000 | 5,226,000 | -1,144,000 | 3,915,000 | 7,174,000 | -254,000 | -254,000 | -713,000 | 2,871,000 | -100,218,000 | -71,868,000 | 17,163,000 | -45,000 | 2,649,000 | 37,000 | 37,000 | 7,416,000 | 149,438,000 | -3,890,000 | -217,000 | -217,000 | 130,000 | -374,000 | 449,000 | 65,287,000 | 65,287,000 | -214,000 | -789,000 | 109,000 | -10,775,000 | -10,775,000 | -371,000 | 415,924,000 | -578,000 | 63,453,000 | 63,453,000 | -155,000 | 1,639,000 | 6,640,000 | 179,389,000 | 179,389,000 | -25,550,000 | -2,842,000 | 162,029,000 | -2,376,000 | -2,376,000 | -24,873,000 | -3,657,000 | -1,531,000 | -3,928,000 | -3,928,000 | -3,676,000 | -4,480,000 | 12,413,000 | -3,627,000 | -3,627,000 | 12,073,000 | 70,354,000 | 1,139,000 | 682,000 | 682,000 | 101,915,000 | -2,194,000 | 8,569,000 | 1,054,000 | 5,905,000 | 47,477,000 | 42,985,000 | 4,566,000 | |||||
net increase in cash and cash equivalents | 106,188,000 | -3,433,000 | -3,433,000 | -133,865,000 | 31,493,000 | 40,467,000 | 135,248,000 | 135,248,000 | -4,008,000 | 83,693,000 | -23,038,000 | 4,592,000 | 4,592,000 | -10,199,000 | 53,561,000 | 53,561,000 | 11,962,000 | 1,163,000 | 1,163,000 | -138,736,000 | -3,791,000 | -3,791,000 | 8,046,000 | -9,069,000 | -126,771,000 | 104,611,000 | 104,611,000 | 2,098,000 | -61,861,000 | 183,468,000 | -13,574,000 | -13,574,000 | -5,869,000 | 20,470,000 | 20,470,000 | 67,669,000 | -15,174,000 | -54,084,000 | 43,630,000 | 6,461,000 | -14,811,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents at beginning of period | 0 | 0 | 0 | 217,374,000 | 217,374,000 | 0 | 0 | 0 | 262,994,000 | 262,994,000 | 0 | 0 | 0 | 0 | 141,634,000 | 141,634,000 | 0 | 0 | 80,395,000 | 80,395,000 | 0 | 0 | 103,978,000 | 103,978,000 | 0 | 0 | 170,069,000 | 170,069,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents at end of period | 106,188,000 | 211,867,000 | -19,319,000 | 183,752,000 | 183,752,000 | -40,972,000 | 59,887,000 | -61,102,000 | 259,561,000 | 259,561,000 | -133,865,000 | -67,621,000 | -18,608,000 | -147,055,000 | 276,882,000 | 276,882,000 | 83,693,000 | -23,038,000 | 84,987,000 | 84,987,000 | -47,275,000 | -10,199,000 | 157,539,000 | 157,539,000 | -39,758,000 | -39,458,000 | 171,232,000 | 171,232,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
supplemental cash flow disclosures: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net cash paid for income taxes | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
non-cash operating activities: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
right-of-use assets obtained in exchange for lease obligations | 0 | 0 | 3,011,000 | 28,000 | 33,977,000 | 1,595,000 | 0 | 0 | 0 | 4,893,000 | 4,893,000 | 2,193,000 | 0 | 1,248,000 | 576,000 | 576,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
impairment of right-of-use assets | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
non-cash investing activity: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
unpaid liabilities incurred for purchases of in-process research and development technology | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
unpaid liabilities incurred for purchases of investment | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of common stock under the equity incentive plans and stock purchase plan | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net decrease in cash and cash equivalents | -19,319,000 | -33,622,000 | -33,622,000 | -40,972,000 | 59,887,000 | 14,145,000 | -16,721,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of common stock under the equity incentive plans | 11,627,000 | 11,627,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
trade receivable | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash paid for taxes | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
depreciation | 7,454,000 | 7,329,000 | 6,378,000 | 6,378,000 | 6,526,000 | 6,296,000 | 6,040,000 | 6,855,000 | 4,490,000 | 4,490,000 | 1,931,000 | 4,804,000 | 3,668,000 | 3,227,000 | 3,227,000 | 2,410,000 | 2,355,000 | 2,201,000 | 2,175,000 | 2,175,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchases of investments | -108,686,000 | -138,468,000 | -138,468,000 | -78,621,000 | -182,519,000 | -329,491,000 | -311,837,000 | -371,305,000 | -387,320,000 | -355,546,000 | -336,545,000 | -336,545,000 | -279,791,000 | -388,474,000 | -357,291,000 | -331,612,000 | -331,612,000 | -203,294,000 | -433,821,000 | -181,649,000 | -251,505,000 | -251,505,000 | -294,984,000 | -369,430,000 | -278,399,000 | -239,869,000 | -239,869,000 | -189,528,000 | -141,292,000 | -110,475,000 | -116,537,000 | -116,537,000 | -71,044,000 | -93,237,000 | -30,315,000 | -124,494,000 | -110,678,000 | -59,113,000 | -150,161,000 | -49,235,000 | -49,235,000 | -24,300,000 | -73,475,000 | -32,935,000 | -13,282,000 | -13,282,000 | -10,291,000 | -26,957,000 | -46,343,000 | -35,937,000 | -35,937,000 | -13,207,000 | -29,017,000 | -51,594,000 | -96,157,000 | -96,157,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from maturities and sales of investments | 215,278,000 | 268,452,000 | 268,452,000 | 153,493,000 | 311,077,000 | 263,143,000 | 310,769,000 | 237,990,000 | 326,412,000 | 232,741,000 | 267,615,000 | 267,615,000 | 282,696,000 | 381,732,000 | 306,657,000 | 407,424,000 | 407,424,000 | 232,351,000 | 261,887,000 | 287,086,000 | 287,086,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of common stock under equity incentive plans | 8,315,000 | 8,315,000 | 7,143,000 | 2,889,000 | 10,900,000 | 4,891,000 | 4,891,000 | 12,696,000 | 2,791,000 | 2,791,000 | 3,938,000 | 3,938,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred revenue | 162,000 | -707,000 | 647,000 | -1,299,000 | -662,000 | -1,169,000 | -1,169,000 | -426,000 | 2,088,000 | -4,076,000 | 13,422,000 | 13,422,000 | -5,063,000 | -5,647,000 | 809,000 | 8,850,000 | 8,850,000 | 1,819,000 | -7,458,000 | 8,562,000 | -2,652,000 | -2,652,000 | -6,965,000 | -7,449,000 | -6,980,000 | 35,139,000 | 5,247,000 | 56,043,000 | -3,333,000 | 198,802,000 | 198,802,000 | 1,000 | 0 | -7,000 | -2,576,000 | -2,576,000 | 1,264,000 | 192,000 | -116,000 | -207,000 | -207,000 | 433,000 | -490,000 | -7,704,000 | -7,110,000 | -7,110,000 | -7,814,000 | -7,813,000 | -7,813,000 | -18,480,000 | -18,480,000 | -69,366,000 | -124,666,000 | -25,099,000 | -25,397,000 | -25,397,000 | 35,256,000 | -42,911,000 | -8,910,000 | -26,380,000 | -26,380,000 | -30,829,000 | 105,768,000 | 14,195,000 | -3,357,000 | -3,357,000 | 189,116,000 | -27,019,000 | -27,537,000 | -1,780,000 | -1,780,000 | 233,000 | -14,168,000 | -24,778,000 | 42,832,000 | 42,832,000 | 41,780,000 | -12,712,000 | -16,354,000 | 26,753,000 | 12,873,000 | -9,222,000 | 18,102,000 | 6,261,000 | ||||||||||||||||||||||
proceeds from issuance of common stock under equity incentive and stock purchase plans | 9,109,000 | 6,917,000 | 6,065,000 | 5,204,000 | 1,744,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net increase in cash, cash equivalents and restricted cash equivalents | 39,402,000 | 65,403,000 | 59,187,000 | 119,380,000 | 99,149,000 | 99,149,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash, cash equivalents and restricted cash equivalents at beginning of period | 502,677,000 | 0 | 0 | 0 | 663,891,000 | 663,891,000 | 0 | 0 | 0 | 320,772,000 | 320,772,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash, cash equivalents and restricted cash equivalents at end of period | 542,079,000 | -174,091,000 | 39,082,000 | -99,590,000 | 737,276,000 | 737,276,000 | 65,403,000 | 59,187,000 | 119,380,000 | 419,921,000 | 419,921,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
non-cash investing activities: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts receivable for unsettled investment sales | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net increase in cash, cash equivalents, and restricted cash equivalents | 39,082,000 | -99,590,000 | 73,385,000 | 73,385,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
unpaid liabilities incurred for purchases of property and equipment | -1,927,000 | -2,404,000 | 18,000 | -1,000 | 39,000 | 323,000 | 481,000 | 481,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
unpaid liabilities incurred in asset acquisition | 0 | -5,000,000 | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
unpaid liabilities incurred for unsettled investment purchases | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from sale of property and equipment | 0 | 150,000 | 0 | 10,000 | 4,000 | 5,000 | -20,000 | 5,000 | 107,000 | 107,000 | 46,000 | 5,000 | 656,000 | 639,000 | 639,000 | 106,000 | 5,000 | 5,000 | 276,000 | 276,000 | 103,000 | 11,000 | -7,000 | 175,000 | 175,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from sales and maturities of investments | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net increase in cash, cash equivalents and restricted cash | -193,097,000 | 169,803,000 | 90,839,000 | 90,839,000 | -127,572,000 | -4,148,000 | 59,162,000 | 59,162,000 | -39,352,000 | 105,216,000 | 15,676,000 | 46,021,000 | 46,021,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash, cash equivalents and restricted cash at beginning of period | 0 | 0 | 268,137,000 | 268,137,000 | 0 | 0 | 315,875,000 | 315,875,000 | 0 | 0 | 0 | 188,314,000 | 188,314,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash, cash equivalents and restricted cash at end of period | -193,097,000 | 169,803,000 | 358,976,000 | 358,976,000 | -127,572,000 | -4,148,000 | 375,037,000 | 375,037,000 | -39,352,000 | 105,216,000 | 15,676,000 | 234,335,000 | 234,335,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
unpaid liabilities incurred to acquire investments | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
principal repayments of debt | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
supplemental cash flow disclosure: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash paid for interest | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
non-cash activities: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
property and equipment deemed to have been acquired in build-to-suit lease | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
401(k) matching contributions made in common stock | 528,000 | 1,082,000 | 2,469,000 | 2,469,000 | 464,000 | 509,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
amortization and other changes in right-of-use assets | 704,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred income taxes | 23,272,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
gain on other equity investments | 0 | 0 | 0 | 0 | -209,000 | -209,000 | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accretion of investments, net and other | -1,051,000 | -1,504,000 | -1,415,000 | -1,415,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other receivables | -1,192,000 | -5,080,000 | 8,741,000 | 8,741,000 | 1,230,000 | -962,000 | -344,000 | -1,114,000 | -1,114,000 | -44,000 | -424,000 | -364,000 | 27,870,000 | 27,870,000 | -25,536,000 | 1,709,000 | -592,000 | 125,000 | 125,000 | 1,410,000 | -1,278,000 | 1,062,000 | 4,774,000 | 4,774,000 | -470,000 | -4,333,000 | -1,447,000 | -2,255,000 | -2,255,000 | 434,000 | 184,000 | 2,686,000 | -3,103,000 | -3,103,000 | -743,000 | -901,000 | 957,000 | 18,385,000 | 18,385,000 | -18,674,000 | -2,151,000 | 4,422,000 | 1,313,000 | -454,000 | -2,163,000 | 8,216,000 | -8,400,000 | 1,073,000 | 792,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of unbilled collaboration revenue | -490,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
prepaid expenses and other current assets | -1,643,000 | 1,299,000 | 871,000 | 871,000 | 500,000 | -1,952,000 | -3,477,000 | 1,900,000 | 1,900,000 | -738,000 | -3,579,000 | 1,930,000 | -881,000 | 1,732,000 | -2,491,000 | 134,000 | -985,000 | -985,000 | -359,000 | -359,000 | 2,529,000 | -1,719,000 | 4,981,000 | -4,757,000 | -4,757,000 | 128,000 | -1,638,000 | 14,000 | -268,000 | -268,000 | 12,075,000 | -2,007,000 | 1,764,000 | -1,279,000 | -1,279,000 | 2,891,000 | -1,528,000 | 1,974,000 | -3,403,000 | -3,403,000 | -4,429,000 | -1,739,000 | -430,000 | -740,000 | -740,000 | -953,000 | 1,441,000 | -512,000 | -1,538,000 | -1,538,000 | 708,000 | -277,000 | -2,481,000 | -915,000 | -915,000 | 1,418,000 | -1,349,000 | -1,200,000 | 486,000 | |||||||||||||||||||||||||||||||||||||||||||||||
other long-term assets | -1,505,000 | 65,000 | -4,854,000 | -4,854,000 | -544,000 | -545,000 | 349,000 | -346,000 | -346,000 | -259,000 | 170,000 | 538,000 | -19,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts payable | -2,731,000 | 1,317,000 | -1,294,000 | -1,294,000 | 2,104,000 | 287,000 | -1,352,000 | -183,000 | -183,000 | 3,587,000 | -1,049,000 | 2,388,000 | -1,916,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accrued compensation and benefits | 7,569,000 | 1,594,000 | -9,592,000 | -9,592,000 | 4,859,000 | 5,745,000 | 782,000 | -317,000 | -317,000 | 1,159,000 | 4,359,000 | 1,065,000 | -5,844,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accrued clinical trial liabilities | 6,621,000 | 654,000 | 4,824,000 | 4,824,000 | -727,000 | 2,157,000 | 1,450,000 | -4,498,000 | -4,498,000 | 3,668,000 | 1,501,000 | 202,000 | 347,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
rebates and fees due customers | -491,000 | -2,435,000 | 4,754,000 | 4,754,000 | 3,265,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accrued collaboration liability | 126,000 | 291,000 | 137,000 | 137,000 | -978,000 | -18,710,000 | 1,717,000 | 2,319,000 | 3,736,000 | 3,736,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current and long-term deferred revenue | -1,064,000 | 5,969,000 | -1,313,000 | -1,313,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term portion of lease liabilities | -690,000 | -740,000 | 7,517,000 | 7,517,000 | -251,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other current and long-term liabilities | 8,231,000 | -13,460,000 | 21,169,000 | 21,169,000 | 5,548,000 | -13,485,000 | 8,631,000 | 1,533,000 | 1,533,000 | -2,289,000 | 4,742,000 | -3,469,000 | 10,926,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchases of property and equipment | -2,059,000 | -1,209,000 | -2,307,000 | -2,307,000 | -17,694,000 | -1,137,000 | -1,504,000 | -808,000 | -587,000 | -33,000 | -401,000 | -682,000 | -682,000 | -333,000 | -20,000 | -63,000 | -31,000 | -31,000 | -22,000 | -108,000 | 40,000 | -384,000 | -384,000 | -92,000 | -677,000 | -673,000 | -729,000 | -729,000 | -1,189,000 | -1,019,000 | -437,000 | -72,000 | -72,000 | -279,000 | -144,000 | -163,000 | -405,000 | -405,000 | -330,000 | -650,000 | -579,000 | -252,000 | -252,000 | -4,316,000 | -750,000 | -444,000 | -398,000 | -398,000 | -1,207,000 | -2,391,000 | -6,171,000 | -5,363,000 | -5,363,000 | -3,249,000 | -4,749,000 | -5,761,000 | -3,640,000 | -3,640,000 | -3,273,000 | -1,540,000 | -4,740,000 | -2,057,000 | -3,238,000 | -2,859,000 | -4,274,000 | -3,986,000 | ||||||||||||||||||||||||||||||||||||||||
proceeds from maturities of investments | 163,628,000 | 128,971,000 | 129,820,000 | 129,820,000 | 49,622,000 | 91,256,000 | 52,444,000 | 87,504,000 | 87,504,000 | 70,255,000 | 65,442,000 | 78,386,000 | 122,507,000 | 50,850,000 | 42,295,000 | 28,232,000 | 30,108,000 | 30,108,000 | 48,595,000 | 35,903,000 | 40,028,000 | 54,410,000 | 54,410,000 | 40,385,000 | 31,248,000 | 90,947,000 | 90,311,000 | 90,311,000 | 73,701,000 | 41,581,000 | 52,793,000 | 157,096,000 | 157,096,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from sale of investments | 1,401,000 | 6,978,000 | 4,699,000 | 4,699,000 | 1,000 | 1,698,000 | 3,999,000 | 6,238,000 | 6,238,000 | 0 | 0 | 0 | 37,294,000 | 0 | 2,249,000 | 0 | 17,000 | 17,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from other equity investments | 0 | 0 | 0 | 0 | 209,000 | 209,000 | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from exercise of stock options | 4,221,000 | 3,773,000 | 6,817,000 | 6,817,000 | 1,686,000 | 3,840,000 | 4,675,000 | 1,875,000 | 1,875,000 | 1,023,000 | 3,552,000 | 3,305,000 | 9,675,000 | 16,031,000 | 7,089,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from employee stock purchase plan | 0 | 1,552,000 | 0 | 1,815,000 | 0 | 1,708,000 | 0 | 294,000 | 0 | 509,000 | 1,000 | 535,000 | 0 | 389,000 | 1,000 | 747,000 | 0 | 1,010,000 | 0 | 1,676,000 | 0 | 1,825,000 | 1,000 | 1,516,000 | 0 | 1,083,000 | 0 | 978,000 | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
principal payments on financing lease obligation | -12,000 | -11,000 | -11,000 | -11,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
amortization and other right-of-use assets | -7,730,000 | -7,730,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
unbilled collaboration revenue | -7,753,000 | -7,753,000 | -38,014,000 | -38,014,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
amortization of right-of-use assets | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss on extinguishment of debt | 0 | 0 | 128,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
amortization of debt discounts and debt issuance costs | 0 | 0 | 93,000 | 89,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
interest paid in kind | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
payments on conversion of convertible notes | -1,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
changes in assets and liabilities: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
trade and other receivables | 70,324,000 | -75,214,000 | -10,755,000 | -10,755,000 | 8,402,000 | -46,660,000 | -9,122,000 | 6,541,000 | 48,921,000 | -73,562,000 | -7,423,000 | -4,938,000 | -4,938,000 | -1,680,000 | 288,000 | -546,000 | 1,292,000 | 1,292,000 | -160,000 | 312,000 | -577,000 | -516,000 | -516,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
operating lease right-of-use assets | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchases of property and equipment and other | -15,221,000 | -12,235,000 | -2,947,000 | -2,947,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
supplemental cash flow disclosure - non-cash investing and financing activity: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
property and equipment deemed to have been acquired under build-to-suit lease | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
unpaid liabilities incurred to acquire property and equipment | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
changes in warrant fair value | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchase of restricted cash and investments | -4,500,000 | -5,000,000 | -2,646,000 | -3,504,000 | -4,500,000 | 0 | -2,146,000 | -2,004,000 | -2,004,000 | -3,034,000 | 1,568,000 | -1,500,000 | -2,684,000 | -2,684,000 | 41,000 | -3,541,000 | -4,139,000 | -504,000 | -504,000 | -2,300,000 | -1,000 | -3,280,000 | -504,000 | -504,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from maturities of restricted cash and investments | 4,000,000 | 5,000,000 | 2,146,000 | 3,504,000 | 4,500,000 | 0 | 646,000 | 2,004,000 | 2,004,000 | 3,035,000 | 4,507,000 | 1,499,000 | 10,748,000 | 10,748,000 | -43,000 | 9,620,000 | 4,179,000 | 6,598,000 | 6,598,000 | 1,300,000 | 6,100,000 | 3,221,000 | 6,647,000 | 6,647,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of common stock | 37,000 | 37,000 | -2,000 | -3,000 | 0 | 0 | 75,646,000 | 75,646,000 | 0 | 0 | 30,000 | 179,347,000 | 179,347,000 | 49,614,000 | 0 | 8,854,000 | 8,247,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents at beginning of year | 0 | 151,686,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents at end of year | -47,967,000 | 183,179,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stock-based compensation expense | 5,289,000 | 5,027,000 | 4,713,000 | 4,566,000 | 3,603,000 | 3,558,000 | 11,185,000 | 11,185,000 | 6,557,000 | 12,026,000 | 1,734,000 | 1,660,000 | 1,660,000 | 1,552,000 | 714,000 | 3,982,000 | 3,758,000 | 3,758,000 | 3,528,000 | 2,898,000 | 2,926,000 | 2,679,000 | 2,679,000 | 2,611,000 | 1,900,000 | 1,990,000 | 2,332,000 | 2,332,000 | 2,690,000 | 2,974,000 | 2,832,000 | 3,603,000 | 3,603,000 | 4,368,000 | 5,463,000 | 4,755,000 | 6,526,000 | 6,526,000 | 5,394,000 | 5,939,000 | 6,481,000 | 5,092,000 | 5,092,000 | 5,826,000 | 5,788,000 | 5,619,000 | 5,674,000 | 5,674,000 | 5,218,000 | 5,229,000 | 5,178,000 | 4,543,000 | 4,543,000 | 4,458,000 | 4,076,000 | 4,443,000 | 4,636,000 | |||||||||||||||||||||||||||||||||||||||||||||||||
repayment of convertible notes and term loan payable | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
payment on conversion of convertible notes | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
construction-in-progress deemed to have been acquired under build-to-suit lease | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
issuance of common stock in settlement of convertible notes | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accrual of interest paid in kind | -13,893,000 | 2,068,000 | 2,069,000 | 2,031,000 | 1,972,000 | 1,936,000 | 1,936,000 | 1,927,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
gain on sale of other equity investments | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from sale of other equity investments | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
principal payments on debt | -80,000,000 | 0 | 0 | -4,164,000 | -217,000 | -217,000 | -376,000 | -375,000 | -479,000 | -10,479,000 | -10,479,000 | -796,000 | -792,000 | -791,000 | -10,791,000 | -10,791,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash flows from operating activities: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
gain on sale of business and other equity investment | -17,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
changes in the fair value of warrants | 76,000 | -62,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from sale of business and other equity investments | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
redemption of convertible notes | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net loss | 35,123,000 | -6,983,000 | -61,347,000 | -35,170,000 | -74,619,000 | -44,729,000 | -26,151,000 | -27,490,000 | -41,274,000 | -24,201,000 | -25,182,000 | -25,197,000 | -23,990,000 | -27,123,000 | -24,522,000 | -22,775,000 | -9,696,000 | -27,411,000 | -51,922,000 | -28,843,000 | -24,995,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
adjustments to reconcile net loss to net cash from operating activities: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accretion of debt discount and debt issuance costs | -2,417,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
gain on sale of equity investment | 0 | -95,000 | -95,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
change in the fair value of warrants | 0 | 0 | 549,000 | 549,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other long term assets | 436,000 | -142,000 | 241,000 | 241,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts payable, accrued compensation and benefits, and other accrued liabilities | 4,527,000 | 8,956,000 | 5,333,000 | 5,333,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
clinical trial liabilities | -794,000 | -454,000 | -1,936,000 | -1,936,000 | -2,784,000 | 1,596,000 | -10,569,000 | -10,569,000 | 3,735,000 | 2,249,000 | 4,160,000 | 4,160,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other long-term liabilities | -322,000 | -235,000 | -258,000 | -258,000 | -306,000 | -464,000 | -615,000 | -288,000 | -288,000 | -671,000 | -277,000 | -250,000 | -229,000 | -229,000 | -1,160,000 | -156,000 | -231,000 | -143,000 | -143,000 | -1,512,000 | 210,000 | -199,000 | -87,000 | -87,000 | -404,000 | -198,000 | -328,000 | -232,000 | -232,000 | -7,064,000 | -227,000 | -877,000 | -152,000 | -152,000 | -6,581,000 | 402,000 | 402,000 | 483,000 | 483,000 | -4,718,000 | 1,084,000 | 499,000 | 831,000 | 831,000 | 505,000 | 1,164,000 | 1,667,000 | 1,097,000 | 1,097,000 | 1,310,000 | 1,326,000 | 1,670,000 | 1,709,000 | 1,725,000 | 1,801,000 | 1,341,000 | 1,612,000 | 1,157,000 | 618,000 | 550,000 | 550,000 | 250,000 | ||||||||||||||||||||||||||||||||||||||||||||
proceeds from sale of equity investments | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
supplemental cash flow disclosure - non-cash financing activity: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
restructuring liability | 130,000 | -1,057,000 | -1,057,000 | -1,449,000 | -2,410,000 | -297,000 | -3,024,000 | -3,024,000 | 403,000 | 298,000 | -1,762,000 | -1,241,000 | -1,241,000 | -430,000 | -1,971,000 | -971,000 | -2,378,000 | -2,378,000 | 8,733,000 | -1,494,000 | -130,000 | -1,865,000 | -1,865,000 | 3,583,000 | -1,478,000 | -1,478,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from equity investment | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accretion of debt discount | 5,285,000 | 5,285,000 | 4,840,000 | 5,303,000 | 7,216,000 | 7,675,000 | 7,675,000 | 7,708,000 | 7,510,000 | 7,328,000 | 6,988,000 | 6,988,000 | 6,845,000 | 6,652,000 | 6,479,000 | 6,314,000 | 6,314,000 | 6,128,000 | 4,147,000 | 2,284,000 | 2,193,000 | 2,193,000 | 2,089,000 | 2,084,000 | 492,000 | 3,324,000 | 3,324,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts payable, accrued compensation, and other accrued liabilities | -1,114,000 | -567,000 | 3,821,000 | -3,416,000 | -3,416,000 | -6,695,000 | 5,349,000 | -10,254,000 | -10,254,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
clinical trial liability | -84,000 | 5,636,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from sale of business and other equity investment | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from exercise of stock options and warrants | 7,124,000 | 0 | 0 | 0 | 120,000 | 120,000 | 47,000 | 3,000 | 6,000 | 16,000 | 16,000 | 28,000 | 731,000 | 4,079,000 | 3,832,000 | 3,794,000 | 3,794,000 | 1,630,000 | 50,000 | 133,000 | 871,000 | 871,000 | 269,000 | 2,000 | 0 | 2,000 | 2,000 | 11,000 | 5,000 | 288,000 | 6,000 | 6,000 | 480,000 | 1,429,000 | 3,211,000 | 3,181,000 | 3,181,000 | 159,000 | 798,000 | 1,562,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
non-cash financing activity: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
issuance of warrants in connection with amendment to convertible notes | 0 | 0 | 0 | 2,762,000 | 2,762,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
restructuring charge for property and equipment | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from sale of equity investment | 0 | 95,000 | 95,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
gain on sale of business | 0 | 0 | -3,297,000 | -4,500,000 | -4,500,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other assets | -5,000 | -5,000 | 17,000 | -1,759,000 | -108,000 | -116,000 | -116,000 | -296,000 | 469,000 | 118,000 | 114,000 | 114,000 | -87,000 | -19,000 | -1,712,000 | 11,000 | 11,000 | 5,313,000 | 370,000 | 371,000 | 370,000 | 370,000 | 416,000 | 345,000 | -3,631,000 | 95,000 | 95,000 | 427,000 | -118,000 | -486,000 | 2,000 | 2,000 | -30,000 | 702,000 | 106,000 | -134,000 | -11,000 | 67,000 | 11,000 | -1,089,000 | -3,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts payable and other accrued liabilities | 9,343,000 | -1,031,000 | 5,851,000 | -5,472,000 | -5,472,000 | 7,269,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from sale of business | 0 | 4,500,000 | 4,500,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from debt issuance | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
gain on warrants | -1,739,000 | -1,739,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
restructuring (credit) charge for property and equipment | -63,000 | 38,000 | 16,000 | -195,000 | -195,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
gain on sale of property and equipment | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
gain on sale of businesses | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from sale of businesses | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
issuance of common stock for settlement of convertible loan, including accrued interest | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
restructuring credit for property and equipment | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net gain on sale of property and equipment | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts payable and other accrued expenses | 3,079,000 | 2,937,000 | -2,736,000 | -2,736,000 | -3,330,000 | -2,411,000 | -2,719,000 | 2,905,000 | 2,905,000 | -8,234,000 | 2,416,000 | -9,776,000 | 6,150,000 | 6,150,000 | 7,703,000 | 4,401,000 | 3,925,000 | -7,021,000 | -7,021,000 | 1,173,000 | 3,796,000 | -303,000 | 2,297,000 | 2,297,000 | 6,667,000 | 6,667,000 | 8,100,000 | 2,258,000 | 614,000 | 1,192,000 | 2,593,000 | 1,225,000 | 3,326,000 | -6,789,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from sales of property and equipment | 18,000 | 12,000 | 847,000 | 847,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds on sale of business | 400,000 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
decrease in restricted cash and investments | -36,121,000 | 0 | 0 | 0 | 2,200,000 | 2,200,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from maturities of marketable securities | 95,219,000 | 80,789,000 | 60,315,000 | 60,315,000 | 7,556,000 | 50,837,000 | 39,689,000 | 26,718,000 | 26,718,000 | 32,469,000 | 23,070,000 | 38,059,000 | 33,971,000 | 33,971,000 | 43,769,000 | 635,000 | 2,425,000 | 2,938,000 | 2,938,000 | 9,000 | 7,871,000 | 9,002,000 | 34,299,000 | 34,299,000 | 15,152,000 | 49,732,000 | 57,095,000 | 34,360,000 | 34,360,000 | 8,133,000 | 26,315,000 | 19,750,000 | 45,443,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from convertible notes | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from note payable and bank obligations | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
principal payments on notes payable and bank obligations | -788,000 | -1,648,000 | -1,646,000 | -1,646,000 | -1,631,000 | -2,440,000 | -798,000 | -3,752,000 | -3,752,000 | -30,690,000 | -2,892,000 | -2,734,000 | -3,247,000 | -3,247,000 | -31,820,000 | -3,659,000 | -3,656,000 | -3,930,000 | -3,930,000 | -5,699,000 | -4,485,000 | -3,636,000 | -3,633,000 | -3,633,000 | -2,857,000 | -2,973,000 | -3,813,000 | -2,499,000 | -2,499,000 | -33,488,000 | -2,842,000 | -1,720,000 | -2,179,000 | -1,724,000 | -3,678,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents, at beginning of period | 0 | 0 | 74,257,000 | 74,257,000 | 0 | 0 | 97,440,000 | 97,440,000 | 0 | 0 | 86,796,000 | 86,796,000 | 0 | 0 | 247,698,000 | 247,698,000 | 0 | 0 | 135,457,000 | 135,457,000 | 0 | 0 | 123,369,000 | 123,369,000 | -15,143,000 | 0 | 96,471,000 | 0 | 0 | 78,105,000 | 0 | 0 | 111,828,000 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents, at end of period | 240,665,000 | -2,326,000 | 70,466,000 | 70,466,000 | -9,069,000 | -126,771,000 | 202,051,000 | 202,051,000 | -61,861,000 | 98,911,000 | 58,292,000 | 58,292,000 | 17,658,000 | -48,513,000 | 201,425,000 | 201,425,000 | -10,817,000 | -46,836,000 | 121,883,000 | 121,883,000 | 35,719,000 | -38,232,000 | 143,839,000 | 143,839,000 | -30,317,000 | -54,084,000 | 140,101,000 | -14,811,000 | 43,437,000 | 61,384,000 | 9,069,000 | -41,399,000 | 80,323,000 | -13,516,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of common stock, net of offering costs | 46,000 | 64,990,000 | 64,990,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from exercise of stock options and warrants, net of repurchases | 197,000 | 109,000 | 109,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
consolidated net income | 46,296,000 | -43,249,000 | -38,336,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
impairment of property and equipment, net of proceeds from sales | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss on deconsolidation of symphony evolution, inc. | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchases of investments held by symphony evolution, inc. | 0 | 0 | -13,000 | -36,000 | -36,000 | -106,000 | -133,000 | -173,000 | -295,000 | -295,000 | -444,000 | -556,000 | -611,000 | -669,000 | -669,000 | -745,000 | -810,000 | -40,440,000 | -343,000 | -351,000 | -325,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds on sale of investments held by symphony evolution, inc. | 0 | 0 | 2,339,000 | 2,158,000 | 2,158,000 | 3,876,000 | 4,036,000 | 5,370,000 | 3,657,000 | 3,657,000 | 8,241,000 | 6,534,000 | 6,854,000 | 4,804,000 | 4,804,000 | 4,102,000 | 3,854,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds on sale of property and equipment | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds on sale of businesses | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
decrease (increase) in restricted cash and investments | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from sale of marketable securities | 0 | 0 | 0 | 12,780,000 | 12,780,000 | -7,027,000 | 27,171,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of stock, net of offering costs | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from notes payable and bank obligations | 0 | 0 | 12,367,000 | 0 | 0 | 2,424,000 | 6,107,000 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
repayments, net from deconsolidation of symphony evolution, inc. | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents, at beginning of year | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents, at end of year | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
impairment of assets due to restructuring | -131,000 | 388,000 | 122,000 | 122,000 | 7,000 | 2,474,000 | 2,474,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
consolidated net loss | -17,865,000 | -43,249,000 | -38,336,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
restructure liability | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from sales of marketable securities | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
impairment of assets | 846,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
gain on sale of plant trait business and artemis pharmaceuticals | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
warrants issued in conjunction with deerfield financing agreement | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accretion of deerfield implied interest | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accrued restructuring liability | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
increase in restricted cash and investments | 0 | 0 | 108,000 | -837,000 | -837,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net decreases in cash and cash equivalents | -28,504,000 | -28,504,000 | 17,658,000 | -48,513,000 | -46,273,000 | -46,273,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
amortization of intangibles | 72,000 | 72,000 | 98,000 | 210,000 | 240,000 | 272,000 | 271,000 | 271,000 | 272,000 | 272,000 | 278,000 | 168,000 | 167,000 | 166,000 | 166,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds on sale of plant trait business | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds on sale of artemis pharmaceuticals | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from the issuance of common stock, net of offering costs | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
effect of foreign exchange rates on cash and cash equivalents | -5,000 | -4,000 | -173,000 | 45,000 | 70,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(increase)/decrease in restricted cash and investments | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
non-cash investing and financing activities: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss attributed to noncontrolling interest | -2,796,000 | -2,681,000 | -3,343,000 | -3,896,000 | -3,896,000 | -2,408,000 | -8,184,000 | -7,460,000 | -6,589,000 | -6,589,000 | -6,863,000 | -5,546,000 | -5,770,000 | -3,518,000 | -4,891,000 | -5,086,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from sale of equipment | 6,000 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds on sale of marketable securities | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net cash provided (used) in investing activities | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
payments on capital lease obligations | 0 | 0 | -8,000 | -90,000 | -249,000 | -384,000 | -634,000 | -664,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from purchase of noncontrolling interest by preferred shareholders in symphony evolution, inc., net of fees | 0 | 0 | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
warrants issued in conjunction with the symphony evolution, inc. financing | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
changes in restricted cash and investments | 840,000 | -361,000 | 1,905,000 | 1,905,000 | 840,000 | 990,000 | -273,000 | -273,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from sale of stock, net of offering costs | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from employee stock purchase plans | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
effect of foreign exchange rate changes on cash and cash equivalents | -183,000 | -11,000 | -58,000 | -58,000 | 14,000 | 37,000 | 18,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss on the sale of equipment | -17,000 | -3,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
change in restricted cash and investments | 1,586,000 | -216,000 | 1,119,000 | 559,000 | 840,000 | 1,231,000 | 727,000 | 560,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
amortization of intangible assets | 51,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
income from the sale of equipment | 5,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from purchase of noncontrolling interest by preferred stockholders in symphony evolution, inc. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
warrants issued in conjunction with the symphony evolution, inc. transaction | 0 | 5,684,000 | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss from the sale of equipment | 5,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from maturities of long term marketable securities | 2,020,000 | 2,020,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
acquired in-process research and development | 25,981,000 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash paid for acquisitions, net of cash acquired | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
repayment of notes from stockholders | 0 | 0 | 0 | 53,000 | 74,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from sale of investments held by symphony evolution, inc. | 6,106,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
principal payments on notes and bank obligations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
gain on the sale of equipment | 0 | -16,000 | -122,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
related-party receivables | 0 | 3,000 | 15,000 | 27,000 | 28,000 | 40,000 | 65,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stock compensation expense | 28,000 | 23,000 | -16,000 | 42,000 | 33,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
non-cash portion of restructuring charge | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
prepaid expense and other current assets | -1,249,000 | -669,000 | -925,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash received from acquisition, net of cash paid | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds on sale of equipment | 0 | 1,000 | 152,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from maturities of short-term investments | 10,618,000 | 35,026,000 | 35,512,000 | 19,482,000 | 64,596,000 | 24,773,000 | 29,307,000 | 52,017,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchases of short-term investments | -41,092,000 | -15,596,000 | -21,285,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from exercise of stock options, net of repurchases | 426,000 | 609,000 | 54,000 | 542,000 | 1,268,000 | 721,000 | 8,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss from discontinued operations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from sale of investments before maturity | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from bank obligations | 4,849,000 | 7,457,000 | 5,933,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
property and equipment acquired under capital leases | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stock compensation expense, net of reversals | 167,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other current assets | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash from acquisition | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
changes in restricted cash | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net cash provided by financing activities | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net cash provided by investing activities | 72,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accrued merger and acquisition costs | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
change in restricted cash | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net cash from (used in) investing activities | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
principal payments on capital lease obligations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net cash used in operating activities |