Dynavax Technologies Corporation(NASDAQ:DVAX)

Dynavax Technologies Corporation, a biopharmaceutical company, focuses on developing and commercializing novel vaccines in the United States. The company markets HEPLISAV-B, a hepatitis B vaccine for prevention of infection caused by all known subtypes of hepatitis B virus in age 18 years and older ...
Website: http://www.dynavax.com
Founded: 1996
Full Time Employees: 231
Sector: Healthcare
Industry: Biotechnology
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| Unit: USD | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2017-12-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | 2016-12-31 | 2016-09-30 | 2016-06-30 | 2016-03-31 | 2015-12-31 | 2015-09-30 | 2015-06-30 | 2015-03-31 | 2014-12-31 | 2014-09-30 | 2014-06-30 | 2014-03-31 | 2013-12-31 | 2013-09-30 | 2013-06-30 | 2013-03-31 | 2012-12-31 | 2012-09-30 | 2012-06-30 | 2012-03-31 | 2011-12-31 | 2011-09-30 | 2011-06-30 | 2011-03-31 | 2010-12-31 | 2010-09-30 | 2010-06-30 | 2010-03-31 | 2009-12-31 | 2009-09-30 | 2009-06-30 | 2009-03-31 | 2008-12-31 | 2008-09-30 | 2008-06-30 | 2008-03-31 | 2007-12-31 | 2007-09-30 | 2007-06-30 | 2007-03-31 | 2006-12-31 | 2006-09-30 | 2006-06-30 | 2006-03-31 | 2005-12-31 | 2005-09-30 | 2005-06-30 | 2005-03-31 | 2004-12-31 | 2004-09-30 | 2004-06-30 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
revenues: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
product revenue | 89,954,000 | 91,872,000 | 64,959,000 | 71,053,000 | 79,345,000 | 70,188,000 | 47,845,000 | 51,086,000 | 62,318,000 | 56,440,000 | 43,451,000 | 182,183,000 | 163,815,000 | 255,320,000 | 112,327,000 | 194,541,000 | 106,996,000 | 52,677,000 | 82,885,000 | 13,112,000 | 13,276,000 | 2,405,000 | 10,514,000 | 10,558,000 | 10,158,000 | 8,301,000 | 5,627,000 | 3,932,000 | 1,461,000 | 1,254,000 | 165,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
other revenue | 4,922,000 | 3,570,000 | 3,205,000 | 979,000 | 1,285,000 | 3,607,000 | 2,945,000 | 4,510,000 | 7,196,000 | 3,809,000 | 3,474,000 | 2,309,000 | 3,920,000 | 1,144,000 | 1,665,000 | 529,000 | 1,274,000 | 90,000 | 450,000 | 6,438,000 | 138,000 | 263,000 | 405,000 | -131,000 | 417,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total revenues | 94,876,000 | 95,442,000 | 68,164,000 | 72,032,000 | 80,630,000 | 73,795,000 | 50,790,000 | 55,596,000 | 69,514,000 | 60,249,000 | 46,925,000 | 184,492,000 | 167,735,000 | 256,464,000 | 113,992,000 | 195,070,000 | 108,270,000 | 52,767,000 | 83,335,000 | 19,550,000 | 13,414,000 | 2,668,000 | 10,919,000 | 10,570,000 | 10,575,000 | 8,301,000 | 5,773,000 | 5,318,000 | 1,461,000 | 1,254,000 | 165,000 | 21,000 | 53,000 | 105,000 | 148,000 | 7,292,000 | 162,000 | 2,647,000 | 942,000 | 685,000 | 1,188,000 | 1,550,000 | 627,000 | 2,277,000 | 2,209,000 | 3,048,000 | 3,498,000 | 2,847,000 | 2,927,000 | 3,392,000 | 2,085,000 | 1,806,000 | 2,874,000 | 2,684,000 | 2,350,000 | 11,427,000 | 1,174,000 | 7,269,000 | 1,744,000 | 1,766,000 | 11,649,000 | 2,191,000 | 8,344,000 | 2,189,000 | 2,901,000 | 15,884,000 | 19,344,000 | 11,945,000 | 8,857,000 | 9,978,000 | 6,314,000 | 9,295,000 | 1,014,000 | 1,800,000 | 1,984,000 | 2,438,000 | 1,592,000 | 529,000 | 288,000 | 600,000 | 404,000 | 953,000 | 12,698,000 | 2,455,000 | 3,660,000 | 5,492,000 |
yoy | 17.67% | 29.33% | 34.21% | 29.56% | 15.99% | 22.48% | 8.24% | -69.87% | -58.56% | -76.51% | -58.83% | -5.42% | 54.92% | 386.03% | 36.79% | 897.80% | 707.14% | 1877.77% | 663.21% | 84.96% | 26.85% | -67.86% | 89.14% | 98.76% | 623.82% | 561.96% | 3398.79% | 25223.81% | 2656.60% | 1094.29% | 11.49% | -99.71% | -67.28% | -96.03% | -84.29% | 964.53% | -86.36% | 70.77% | 50.24% | -69.92% | -46.22% | -49.15% | -82.08% | -20.02% | -24.53% | -10.14% | 67.77% | 57.64% | 1.84% | 26.38% | -11.28% | -84.20% | 144.80% | -63.08% | 34.75% | 547.06% | -89.92% | 231.77% | -79.10% | -19.32% | 301.55% | -86.21% | -56.87% | -81.67% | -67.25% | 59.19% | 206.37% | 28.51% | 773.47% | 454.33% | 218.25% | 281.26% | -36.31% | 240.26% | 588.89% | 306.33% | 294.06% | -44.49% | -97.73% | -75.56% | -88.96% | -82.65% | ||||
qoq | -0.59% | 40.02% | -5.37% | -10.66% | 9.26% | 45.29% | -8.64% | -20.02% | 15.38% | 28.39% | -74.57% | 9.99% | -34.60% | 124.98% | -41.56% | 80.17% | 105.19% | -36.68% | 326.27% | 45.74% | 402.77% | -75.57% | 3.30% | -0.05% | 27.39% | 43.79% | 8.56% | 264.00% | 16.51% | 660.00% | 685.71% | -60.38% | -49.52% | -29.05% | -97.97% | 4401.23% | -93.88% | 181.00% | 37.52% | -42.34% | -23.35% | 147.21% | -72.46% | 3.08% | -27.53% | -12.86% | 22.87% | -2.73% | -13.71% | 62.69% | 15.45% | -37.16% | 7.08% | 14.21% | -79.43% | 873.34% | -83.85% | 316.80% | -1.25% | -84.84% | 431.68% | -73.74% | 281.18% | -24.54% | -81.74% | -17.89% | 61.94% | 34.87% | -11.23% | 58.03% | -32.07% | 816.67% | -43.67% | -9.27% | -18.62% | 53.14% | 200.95% | 83.68% | -52.00% | 48.51% | -57.61% | -92.49% | 417.23% | -32.92% | -33.36% | |
operating expenses: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cost of sales - product | 14,403,000 | 14,035,000 | 13,769,000 | 13,410,000 | 13,084,000 | 11,985,000 | 10,966,000 | 8,689,000 | 13,229,000 | 13,537,000 | 14,712,000 | 77,488,000 | 61,334,000 | 83,369,000 | 39,962,000 | 74,012,000 | 60,090,000 | 14,845,000 | 24,625,000 | 4,058,000 | 4,031,000 | 967,000 | 2,354,000 | 2,407,000 | 3,824,000 | 2,141,000 | 1,800,000 | 1,625,000 | 3,927,000 | 5,177,000 | 205,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
research and development | 19,116,000 | 16,619,000 | 19,377,000 | 18,669,000 | 14,403,000 | 14,950,000 | 13,528,000 | 14,119,000 | 14,116,000 | 13,046,000 | 13,605,000 | 12,854,000 | 12,962,000 | 9,689,000 | 11,095,000 | 11,117,000 | 6,186,000 | 7,167,000 | 7,758,000 | 9,549,000 | 8,521,000 | 5,884,000 | 4,653,000 | 12,269,000 | 12,660,000 | 16,196,000 | 21,206,000 | 22,892,000 | 16,820,000 | 16,273,000 | 18,966,000 | 17,412,000 | 16,417,000 | 14,814,000 | 16,345,000 | 18,442,000 | 23,234,000 | 22,750,000 | 20,067,000 | 20,932,000 | 24,105,000 | 19,686,000 | 22,220,000 | 19,638,000 | 28,072,000 | 23,639,000 | 13,231,000 | 12,131,000 | 11,770,000 | 12,805,000 | 14,164,000 | 12,515,000 | 12,850,000 | 11,376,000 | 12,405,000 | 11,616,000 | 11,777,000 | 13,257,000 | 14,672,000 | 12,951,000 | 14,204,000 | 14,045,000 | 12,480,000 | 9,506,000 | 9,631,000 | 9,239,000 | 10,332,000 | 6,249,000 | 10,456,000 | 12,946,000 | 15,120,000 | 18,183,000 | 14,909,000 | 19,164,000 | 13,632,000 | 19,981,000 | 12,781,000 | 10,762,000 | 6,592,000 | 7,942,000 | 6,797,000 | 7,493,000 | 5,655,000 | 5,420,000 | 5,928,000 | 6,510,000 |
selling, general and administrative | 40,086,000 | 50,359,000 | 47,678,000 | 41,585,000 | 43,061,000 | 41,662,000 | 44,065,000 | 41,279,000 | 38,053,000 | 37,071,000 | 36,543,000 | 31,015,000 | 32,042,000 | 36,179,000 | 32,172,000 | 29,224,000 | 26,926,000 | 21,583,000 | 22,423,000 | 17,838,000 | 21,538,000 | 18,954,000 | 20,926,000 | 20,318,000 | 18,459,000 | 17,861,000 | 18,348,000 | 16,438,000 | 15,788,000 | 15,653,000 | 16,891,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
bad debt expense | 10,970,000 | 12,313,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total operating expenses | 73,605,000 | 81,013,000 | 91,794,000 | 73,664,000 | 70,548,000 | 68,597,000 | 68,559,000 | 64,087,000 | 64,398,000 | 63,654,000 | 77,173,000 | 121,357,000 | 106,338,000 | 128,237,000 | 83,229,000 | 114,353,000 | 92,202,000 | 43,595,000 | 54,806,000 | 31,445,000 | 27,239,000 | 26,007,000 | 30,231,000 | 37,959,000 | 41,204,000 | 47,272,000 | 43,627,000 | 43,279,000 | 40,358,000 | 39,401,000 | 38,479,000 | 27,862,000 | 22,444,000 | 20,426,000 | 25,600,000 | 26,613,000 | 35,000,000 | 31,901,000 | 28,236,000 | 27,631,000 | 29,629,000 | 24,784,000 | 27,079,000 | 24,690,000 | 32,286,000 | 27,902,000 | 17,465,000 | 15,839,000 | 18,495,000 | 20,441,000 | 22,964,000 | 21,808,000 | 19,971,000 | 17,333,000 | 18,198,000 | 16,161,000 | 15,994,000 | 17,365,000 | 19,671,000 | 17,381,000 | 18,400,000 | 18,463,000 | 17,295,000 | 13,803,000 | 13,612,000 | 13,017,000 | 15,001,000 | 10,053,000 | 14,614,000 | 16,611,000 | 19,936,000 | 23,312,000 | 20,189,000 | 23,622,000 | 18,063,000 | 24,429,000 | 17,688,000 | 18,518,000 | 9,195,000 | 10,068,000 | 9,116,000 | 9,966,000 | 7,995,000 | 7,950,000 | 7,945,000 | 8,587,000 |
income from operations | 21,271,000 | 14,429,000 | -23,630,000 | -1,632,000 | 10,082,000 | 5,198,000 | -17,769,000 | -8,491,000 | 5,116,000 | -3,405,000 | -30,248,000 | 63,135,000 | 61,397,000 | 128,227,000 | 30,763,000 | 80,717,000 | 16,068,000 | 9,172,000 | 28,529,000 | -11,895,000 | -13,825,000 | -23,339,000 | -19,312,000 | -27,389,000 | -30,629,000 | -38,971,000 | -37,854,000 | -37,961,000 | -38,897,000 | -38,147,000 | -38,314,000 | -27,841,000 | -22,391,000 | -20,321,000 | -25,452,000 | -19,321,000 | -34,838,000 | -29,254,000 | -27,294,000 | -26,946,000 | -28,441,000 | -23,234,000 | -26,452,000 | -22,413,000 | -30,077,000 | -24,854,000 | -13,967,000 | -12,992,000 | -15,568,000 | -17,049,000 | -20,879,000 | -20,002,000 | -17,097,000 | -14,649,000 | -15,848,000 | -4,734,000 | -14,820,000 | -10,096,000 | -17,927,000 | -15,615,000 | -6,751,000 | -16,272,000 | -8,951,000 | -11,614,000 | -10,711,000 | 2,867,000 | 4,343,000 | 1,892,000 | -5,757,000 | -6,633,000 | -13,622,000 | -14,017,000 | -19,175,000 | -21,822,000 | -16,079,000 | -21,991,000 | -16,096,000 | -17,989,000 | -8,907,000 | -9,468,000 | -8,712,000 | -9,013,000 | 4,703,000 | -5,495,000 | -4,285,000 | -3,095,000 |
yoy | 110.98% | 177.59% | 32.98% | -80.78% | 97.07% | -252.66% | -41.26% | -113.45% | -91.67% | -102.66% | -198.33% | -21.78% | 282.11% | 1298.03% | 7.83% | -778.58% | -216.22% | -139.30% | -247.73% | -56.57% | -54.86% | -40.11% | -48.98% | -27.85% | -21.26% | 2.16% | -1.20% | 36.35% | 73.72% | 87.72% | 50.53% | 44.10% | -35.73% | -30.54% | -6.75% | -28.30% | 22.49% | 25.91% | 3.18% | 20.22% | -5.44% | -6.52% | 89.39% | 72.51% | 93.20% | 45.78% | -33.11% | -35.05% | -8.94% | 16.38% | 31.75% | 322.52% | 15.36% | 45.10% | -11.60% | -69.68% | 119.52% | -37.95% | 100.28% | 34.45% | -36.97% | -667.56% | -306.10% | -713.85% | 86.05% | -143.22% | -131.88% | -113.50% | -69.98% | -69.60% | -15.28% | -36.26% | 19.13% | 21.31% | 80.52% | 132.27% | 84.76% | 99.59% | -289.39% | 72.30% | 103.31% | 191.21% | ||||
qoq | 47.42% | -161.06% | 1347.92% | -116.19% | 93.96% | -129.25% | 109.27% | -265.97% | -250.25% | -88.74% | -147.91% | 2.83% | -52.12% | 316.82% | -61.89% | 402.35% | 75.19% | -67.85% | -339.84% | -13.96% | -40.76% | 20.85% | -29.49% | -10.58% | -21.41% | 2.95% | -0.28% | -2.41% | 1.97% | -0.44% | 37.62% | 24.34% | 10.19% | -20.16% | 31.73% | -44.54% | 19.09% | 7.18% | 1.29% | -5.26% | 22.41% | -12.17% | 18.02% | -25.48% | 21.01% | 77.95% | 7.50% | -16.55% | -8.69% | -18.34% | 4.38% | 16.99% | 16.71% | -7.57% | 234.77% | -68.06% | 46.79% | -43.68% | 14.81% | 131.30% | -58.51% | 81.79% | -22.93% | 8.43% | -473.60% | -33.99% | 129.55% | -132.86% | -13.21% | -51.31% | -2.82% | -26.90% | -12.13% | 35.72% | -26.88% | 36.62% | -10.52% | 101.96% | -5.93% | 8.68% | -3.34% | -291.64% | -185.59% | 28.24% | 38.45% | |
operating margin % | 22.42% | 15.12% | -34.67% | -2.27% | 12.50% | 7.04% | -34.99% | -15.27% | 7.36% | -5.65% | -64.46% | 34.22% | 36.60% | 50.00% | 26.99% | 41.38% | 14.84% | 17.38% | 34.23% | -60.84% | -103.06% | -874.78% | -176.87% | -259.12% | -289.64% | -469.47% | -655.71% | -713.82% | -2662.35% | -3042.03% | -23220.61% | -132576.19% | -42247.17% | -19353.33% | -17197.30% | -264.96% | -21504.94% | -1105.18% | -2897.45% | -3933.72% | -2394.02% | -1498.97% | -4218.82% | -984.32% | -1361.57% | -815.42% | -399.29% | -456.34% | -531.88% | -502.62% | -1001.39% | -1107.53% | -594.89% | -545.79% | -674.38% | -41.43% | -1262.35% | -138.89% | -1027.92% | -884.20% | -57.95% | -742.67% | -107.27% | -530.56% | -369.22% | 18.05% | 22.45% | 15.84% | -65.00% | -66.48% | -215.74% | -150.80% | -1891.03% | -1212.33% | -810.43% | -902.01% | -1011.06% | -3400.57% | -3092.71% | -1578.00% | -2156.44% | -945.75% | 37.04% | -223.83% | -117.08% | -56.35% |
other income: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
interest income | 6,593,000 | 6,798,000 | 7,739,000 | 8,414,000 | 9,382,000 | 9,201,000 | 9,468,000 | 9,556,000 | 8,462,000 | 7,378,000 | 6,597,000 | 4,324,000 | 2,562,000 | 765,000 | 261,000 | 6,000 | 39,000 | 48,000 | 47,000 | 70,000 | 269,000 | 331,000 | 590,000 | 766,000 | 890,000 | 979,000 | 735,000 | 888,000 | 1,047,000 | 1,153,000 | 740,000 | 528,000 | 429,000 | 235,000 | 145,000 | 140,000 | 170,000 | 220,000 | 225,000 | 127,000 | 33,000 | 18,000 | 27,000 | 29,000 | 42,000 | 55,000 | 65,000 | -47,000 | 37,000 | 54,000 | 72,000 | 83,000 | 91,000 | 65,000 | 52,000 | 29,000 | 18,000 | 23,000 | 33,000 | 32,000 | 12,000 | 39,000 | 2,000 | 43,500 | 18,000 | 46,000 | 110,000 | 735,000 | 706,000 | 428,000 | 434,000 | 367,000 | 332,000 | 252,000 | 186,000 | |||||||||||
interest expense | -1,643,000 | -1,641,000 | -1,692,000 | -1,704,000 | -1,699,000 | -1,698,000 | -1,695,000 | -1,692,000 | -1,691,000 | -1,688,000 | -1,686,000 | -1,684,000 | -1,685,000 | -1,683,000 | -1,680,000 | -1,679,000 | -1,676,000 | -3,109,000 | -4,712,000 | -4,805,000 | -4,794,000 | -4,732,000 | -4,731,000 | -4,866,000 | -4,779,000 | -4,598,000 | -2,734,000 | -2,751,000 | -2,735,000 | -2,691,000 | -1,161,000 | -62,000 | -263,000 | -247,000 | -20,750 | -24,000 | -27,000 | -32,000 | -586,000 | -589,000 | -589,000 | -587,000 | -495,000 | -485,000 | -487,000 | -490,000 | -425,000 | -399,000 | -431,000 | -399,000 | -4,000 | -93,000 | -12,000 | -15,000 | -16,000 | -6,457,000 | -1,340,000 | -1,344,000 | ||||||||||||||||||||||||||||
sublease income | 2,225,000 | 2,226,000 | 2,226,000 | 2,206,000 | 2,205,000 | 2,205,000 | -1,602,000 | 1,993,000 | 1,993,000 | 1,993,000 | 1,598,000 | 2,025,000 | 2,026,000 | 2,025,000 | 1,609,000 | 2,021,000 | 2,022,000 | 1,670,000 | 2,022,000 | 1,927,000 | 1,926,000 | 1,927,000 | 1,926,000 | 1,728,000 | 891,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss on debt extinguishment | -82,095,000 | -5,232,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other loss | -27,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net income before income taxes | 28,419,000 | 21,216,000 | 7,629,000 | 19,818,000 | 14,906,000 | 996,000 | 14,146,000 | 4,207,000 | -23,716,000 | 56,581,250 | 64,092,000 | 129,374,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
provision for income taxes | -1,492,000 | -2,495,000 | -3,520,000 | -776,000 | -616,000 | -241,000 | -283,000 | -619,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net income | 26,927,000 | 18,721,000 | -96,099,000 | 7,050,000 | 17,594,000 | 11,386,000 | -8,721,000 | 219,000 | 14,293,000 | 3,431,000 | -24,332,000 | 67,733,000 | 63,809,000 | 128,755,000 | 32,859,000 | 99,779,000 | -28,430,000 | 4,473,000 | 891,000 | -15,467,000 | 4,401,000 | -51,579,000 | -12,595,000 | -36,756,000 | -33,459,000 | -42,713,000 | -39,672,000 | -39,969,000 | -40,528,000 | -39,444,000 | -38,958,000 | -27,421,000 | -22,128,000 | -20,318,000 | -25,287,000 | -21,741,000 | -34,694,000 | -28,986,000 | -27,023,000 | -26,862,000 | -30,124,000 | -23,591,000 | -26,217,000 | -22,286,000 | -29,819,000 | -24,777,000 | -13,840,000 | -13,056,000 | -15,675,000 | -17,164,000 | -20,825,000 | -20,543,000 | -17,791,000 | -15,110,000 | -16,505,000 | -4,267,000 | -15,229,000 | -10,635,000 | -18,466,000 | -15,122,000 | -4,998,000 | -28,004,000 | -9,184,000 | -11,640,000 | -10,706,000 | 3,127,000 | 4,092,000 | 3,099,000 | -5,420,000 | -6,079,000 | -12,429,000 | -12,076,000 | -17,101,000 | -17,704,000 | -13,090,000 | -16,455,000 | -12,152,000 | -15,273,000 | -8,172,000 | -8,762,000 | -8,284,000 | -8,579,000 | 5,070,000 | -5,163,000 | -4,033,000 | -2,909,000 |
yoy | 53.05% | 64.42% | 1001.93% | 3119.18% | 23.10% | 231.86% | -64.16% | -99.68% | -77.60% | -97.34% | -174.05% | -32.12% | -324.44% | 2778.49% | 3587.88% | -745.11% | -745.99% | -108.67% | -107.07% | -57.92% | -113.15% | 20.76% | -68.25% | -8.04% | -17.44% | 8.29% | 1.83% | 45.76% | 83.15% | 94.13% | 54.06% | 26.13% | -36.22% | -29.90% | -6.42% | -19.06% | 15.17% | 22.87% | 3.07% | 20.53% | 1.02% | -4.79% | 89.43% | 70.70% | 90.23% | 44.35% | -33.54% | -36.45% | -11.89% | 13.59% | 26.17% | 381.44% | 16.82% | 42.08% | -10.62% | -71.78% | 204.70% | -62.02% | 101.07% | 29.91% | -53.32% | -995.55% | -324.44% | -475.61% | 97.53% | -151.44% | -132.92% | -125.66% | -68.31% | -65.66% | -5.05% | -26.61% | 40.73% | 15.92% | 60.18% | 87.80% | 46.69% | 78.03% | -261.18% | 69.71% | 105.41% | 194.91% | ||||
qoq | 43.83% | -119.48% | -1463.11% | -59.93% | 54.52% | -230.56% | -4082.19% | -98.47% | 316.58% | -114.10% | -135.92% | 6.15% | -50.44% | 291.84% | -67.07% | -450.96% | -735.59% | 402.02% | -105.76% | -451.44% | -108.53% | 309.52% | -65.73% | 9.85% | -21.67% | 7.67% | -0.74% | -1.38% | 2.75% | 1.25% | 42.07% | 23.92% | 8.91% | -19.65% | 16.31% | -37.33% | 19.69% | 7.26% | 0.60% | -10.83% | 27.69% | -10.02% | 17.64% | -25.26% | 20.35% | 79.02% | 6.00% | -16.71% | -8.68% | -17.58% | 1.37% | 15.47% | 17.74% | -8.45% | 286.81% | -71.98% | 43.20% | -42.41% | 22.11% | 202.56% | -82.15% | 204.92% | -21.10% | 8.72% | -442.37% | -23.58% | 32.04% | -157.18% | -10.84% | -51.09% | 2.92% | -29.38% | -3.41% | 35.25% | -20.45% | 35.41% | -20.43% | 86.89% | -6.73% | 5.77% | -3.44% | -269.21% | -198.20% | 28.02% | 38.64% | |
net income margin % | 28.38% | 19.62% | -140.98% | 9.79% | 21.82% | 15.43% | -17.17% | 0.39% | 20.56% | 5.69% | -51.85% | 36.71% | 38.04% | 50.20% | 28.83% | 51.15% | -26.26% | 8.48% | 1.07% | -79.12% | 32.81% | -1933.25% | -115.35% | -347.74% | -316.40% | -514.55% | -687.20% | -751.58% | -2773.99% | -3145.45% | -23610.91% | -130576.19% | -41750.94% | -19350.48% | -17085.81% | -298.15% | -21416.05% | -1095.05% | -2868.68% | -3921.46% | -2535.69% | -1522.00% | -4181.34% | -978.74% | -1349.89% | -812.89% | -395.65% | -458.59% | -535.53% | -506.01% | -998.80% | -1137.49% | -619.03% | -562.97% | -702.34% | -37.34% | -1297.19% | -146.31% | -1058.83% | -856.29% | -42.90% | -1278.14% | -110.07% | -531.75% | -369.05% | 19.69% | 21.15% | 25.94% | -61.19% | -60.92% | -196.85% | -129.92% | -1686.49% | -983.56% | -659.78% | -674.94% | -763.32% | -2887.15% | -2837.50% | -1460.33% | -2050.50% | -900.21% | 39.93% | -210.31% | -110.19% | -52.97% |
net income per share | -0.41 | -0.49 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic | 0.23 | 0.16 | -0.77 | 0.06 | 0.13 | 0.09 | -0.07 | 0.11 | 0.03 | -0.19 | 0.53 | 0.5 | 1.02 | 0.26 | 0.82 | -0.24 | 0.04 | 0.01 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
diluted | 0.21 | 0.14 | -0.77 | 0.05 | 0.12 | 0.08 | -0.07 | 0.1 | 0.03 | -0.19 | 0.46 | 0.43 | 0.87 | 0.22 | 0.77 | -0.24 | 0.02 | 0.01 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
weighted-average shares used for eps calculation | 100,753 | 109,816 | 97,339 | 85,477 | 72,024 | 75,106 | 65,088 | 63,778 | 62,362 | 62,650 | 62,346 | 61,744 | 52,613 | 57,650 | 49,700 | 41,830 | 38,506 | 38,512 | 38,496 | 38,472 | 36,532 | 29,335 | 183,022 | 182,913 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic | 117,307 | 119,317 | 124,871 | 130,047 | 131,133 | 130,916 | 130,200 | 128,733 | 128,988 | 128,625 | 127,921 | 126,398 | 127,062 | 126,347 | 124,555 | 116,264 | 116,903 | 114,629 | 112,035 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
diluted | 136,468 | 138,356 | 124,871 | 133,344 | 154,807 | 154,468 | 130,200 | 128,733 | 154,196 | 152,142 | 127,921 | 150,797 | 151,538 | 149,905 | 149,425 | 133,006 | 116,903 | 118,830 | 113,469 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other income | -596,000 | -423,000 | 322,000 | 505,000 | 168,000 | -123,000 | 181,000 | 18,750 | 57,000 | 241,000 | -223,000 | -108,000 | -166,000 | -232,000 | 20,000 | -2,560,000 | -26,000 | 48,000 | 46,000 | -43,000 | 17,000 | -112,000 | 455,000 | 133,000 | 216,000 | 22,000 | 62,000 | -100,000 | -120,000 | -142,000 | 14,000 | -38,000 | -196,000 | 63,000 | -122,000 | 933,000 | 58,000 | -75,000 | -82,000 | 886,000 | 2,140,000 | -11,340,000 | 164,000 | -10,000 | 80,000 | 226,000 | -346,000 | |||||||||||||||||||||||||||||||||||||||
net loss before income taxes | -97,875,000 | -11,497,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
benefit from income taxes | 1,776,000 | -741,750 | -2,224,000 | 2,776,000 | -311,250 | 147,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
gain on sale of assets | -1,000,000 | -1,000,000 | -1,000,000 | -6,851,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other | 345,000 | -152,000 | 101,000 | -370,000 | 266,000 | -71,000 | 23,000 | 174,000 | -208,000 | 40,000 | 105,000 | 300,000 | 238,000 | -173,000 | 557,000 | -688,000 | -420,000 | -111,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
change in fair value of warrant liability | 1,801,000 | 19,222,000 | -45,121,000 | 2,097,000 | -25,552,000 | -76,000 | 21,245,000 | -25,655,000 | 8,610,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cost of sales - amortization of intangible assets | 202,000 | 2,298,000 | 2,323,000 | 2,324,000 | 2,297,000 | 2,273,000 | 2,324,000 | 3,823,000 | 2,298,000 | 2,417,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
restructuring | 642,000 | 3,937,000 | 8,777,000 | 2,783,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock deemed dividend | -3,267,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net income allocable to common stockholders | -15,467,000 | 4,401,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic net income per share allocable to common stockholders | -0.14 | 0.04 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
weighted-average shares used for eps calculation | 100,753 | 109,816 | 97,339 | 85,477 | 72,024 | 75,106 | 65,088 | 63,778 | 62,362 | 62,650 | 62,346 | 61,744 | 52,613 | 57,650 | 49,700 | 41,830 | 38,506 | 38,512 | 38,496 | 38,472 | 36,532 | 29,335 | 183,022 | 182,913 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
diluted net loss per share allocable to common stockholders | -0.163 | -0.15 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic and diluted net loss per share | -0.53 | -0.66 | -0.62 | -0.64 | -0.65 | -0.63 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic net loss per share | -0.15 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
diluted net loss per share | -0.25 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net loss allocable to common stockholders | -36,756,000 | -36,726,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net income per share | -0.41 | -0.49 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
collaboration revenue | 146,000 | 7,200,000 | 1,683,000 | 895,000 | 535,000 | 829,000 | 930,000 | 471,000 | 1,734,000 | 1,795,000 | 2,031,000 | 2,373,000 | 1,580,000 | 1,110,000 | 1,356,000 | 883,000 | 1,008,000 | 1,050,000 | 1,623,000 | 929,000 | 10,092,000 | 369,000 | 6,363,000 | 366,000 | 371,000 | 10,402,000 | 1,341,000 | 7,421,000 | 1,455,000 | 1,791,000 | 14,596,000 | 17,692,000 | 10,231,000 | 7,960,000 | 7,701,000 | 5,774,000 | 7,097,000 | 719,000 | 752,000 | 747,000 | 1,391,000 | 166,000 | 12,199,000 | 2,138,000 | 3,769,000 | 5,131,000 | ||||||||||||||||||||||||||||||||||||||||
grant revenue | -11,000 | 53,000 | 105,000 | 148,000 | 92,000 | 162,000 | 88,000 | 39,000 | 75,000 | 359,000 | 101,000 | 148,000 | 142,000 | 414,000 | 1,007,000 | 1,125,000 | 1,283,000 | 1,700,000 | 1,395,000 | 760,000 | 751,000 | 1,219,000 | 882,000 | 1,087,000 | 673,000 | 658,000 | 890,000 | 889,000 | 1,243,000 | 1,218,000 | 617,000 | 862,000 | 556,000 | 887,000 | 895,000 | 1,139,000 | 972,000 | 581,000 | 1,122,000 | 324,000 | 1,198,000 | 133,000 | 587,000 | 1,128,000 | 222,000 | 734,000 | 305,000 | 288,000 | 600,000 | 404,000 | 953,000 | 499,000 | 317,000 | -109,000 | 361,000 | |||||||||||||||||||||||||||||||
basic and diluted net income per share | -0.63 | -0.45 | -0.38 | -0.41 | -0.6 | -0.56 | -0.9 | -0.75 | -0.7 | -0.608 | -0.82 | -0.8 | -0.97 | -0.065 | -0.11 | -0.09 | -0.05 | -0.073 | -0.09 | -0.09 | -0.11 | -0.11 | -0.1 | -0.09 | -0.11 | -0.093 | -0.12 | -0.09 | -0.16 | 0.08 | -0.14 | -0.15 | -0.31 | -0.3 | -0.43 | -0.45 | -0.33 | -0.44 | -0.4 | -0.5 | -0.12 | -0.33 | -0.35 | -0.135 | -0.16 | -0.12 | ||||||||||||||||||||||||||||||||||||||||
service and license revenue | 876,000 | 8,000 | 75,000 | 519,000 | 8,000 | 401,000 | 10,000 | -16,000 | 117,000 | 641,000 | 442,000 | 47,000 | 605,000 | 179,000 | 334,000 | 662,000 | 147,000 | 16,000 | 489,000 | 152,000 | 29,000 | 233,000 | 61,000 | 178,000 | 223,000 | 393,000 | 513,000 | 742,000 | 316,000 | 1,155,000 | 216,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
general and administrative | 4,527,750 | 6,027,000 | 5,612,000 | 6,472,000 | 8,171,000 | 11,766,000 | 9,151,000 | 8,169,000 | 6,699,000 | 5,524,000 | 5,098,000 | 4,859,000 | 5,052,000 | 4,083,000 | 4,085,000 | 4,157,000 | 3,700,000 | 5,807,000 | 7,636,000 | 8,800,000 | 9,293,000 | 7,121,000 | 5,957,000 | 5,793,000 | 4,545,000 | 4,217,000 | 4,054,000 | 4,754,000 | 4,185,000 | 3,951,000 | 4,173,000 | 4,570,000 | 4,052,000 | 3,736,000 | 3,533,000 | 4,424,000 | 3,559,000 | 3,913,000 | 3,420,000 | 4,571,000 | 4,879,000 | 5,029,000 | 4,206,000 | 4,180,000 | 4,197,000 | 4,656,000 | 3,380,000 | 2,603,000 | 2,126,000 | 2,319,000 | 2,473,000 | 2,340,000 | 2,530,000 | 2,017,000 | 2,077,000 | |||||||||||||||||||||||||||||||
loss on extinguishment of debt | -1,671,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
unoccupied facility expense | 131,000 | 178,000 | 77,000 | 8,000 | 918,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
weighted-average number of shares used to compute basic and diluted net income per share | 27,065 | 262,908 | 262,861 | 262,826 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
shares used to compute basic and diluted net income per share | 182,847 | 3,430 | 177,870 | 167,697 | 155,431 | 29,811 | 124,069 | 117,864 | 115,726 | 12 | 39,831 | 39,806 | 39,785 | 6 | 39,753 | 39,741 | 39,727 | 1,788 | 30,605 | 30,536 | 6,185 | 24,751 | 24,745 | 5,008.5 | 24,609 | 24,594 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
amortization of intangible assets | 54,000 | 245,000 | 245,000 | 245,000 | 245,000 | 245,000 | 245,000 | 245,000 | 245,000 | 245,000 | 245,000 | 245,000 | 245,000 | 245,000 | 250,000 | 251,000 | 252,000 | 251,000 | 251,000 | 251,000 | 196,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
add: losses attributable to noncontrolling interest in symphony dynamo inc. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net income attributable to dynavax | -15,122,000 | -4,998,000 | -28,004,000 | -9,184,000 | -30,270,000 | -9,506,000 | 4,110,000 | 5,101,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic and diluted net income per share attributable to dynavax common stockholders | -0.12 | -0.06 | -0.17 | 0.13 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
shares used to compute basic and diluted net income per share attributable to dynavax common stockholders | 7,944 | 86,826 | 54,364 | 360 | 40,153 | 39,889 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic net income per share attributable to dynavax common stockholders | -0.34 | -0.003 | -0.24 | 0.1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
shares used to compute basic net income per share attributable to dynavax common stockholders | 82,012 | 39,923 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
diluted net income per share attributable to dynavax common stockholders | -0.34 | 0.1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
shares used to compute diluted net income per share attributable to dynavax common stockholders | 82,012 | 40,064 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
add: losses attributable to noncontrolling interest in sdi | 1,041,000 | 1,200,000 | 983,000 | 1,009,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loan forgiveness | 5,000,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
interest and other income | 284,000 | 81,000 | 405,000 | 971,000 | 1,659,000 | 453,000 | 1,081,000 | 973,000 | 1,095,000 | 673,000 | 685,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss including noncontrolling interest in sdi | 2,160,000 | -7,133,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
amount attributed to noncontrolling interest in sdi | 939,000 | 1,713,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss including noncontrolling interest in symphony dynamo, inc. | -7,568,000 | -13,995,000 | -14,077,000 | -18,722,000 | -20,741,000 | -15,106,000 | -20,896,000 | -15,423,000 | -17,304,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
amount attributed to noncontrolling interest in symphony dynamo, inc. | 1,489,000 | 1,566,000 | 2,001,000 | 1,621,000 | 3,037,000 | 2,016,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
services and license revenue | 183,000 | 162,000 | 461,000 | 109,000 | 229,000 | 692,000 | 224,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
acquired in-process research and development | 4,180,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss attributed to noncontrolling interest in symphony dynamo, inc. | 1,325,500 | 3,271,000 | 2,031,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic net income per share | -0.27 | 0.21 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
shares used to compute basic net income per share | 30,487 | 24,722 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
diluted net income per share | -0.27 | 0.2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
shares used to compute diluted net income per share | 30,487 | 24,837 |
Balance Sheets:
Quarterly
Annual
| Unit: USD | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2017-12-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | 2016-12-31 | 2016-09-30 | 2016-06-30 | 2016-03-31 | 2015-12-31 | 2015-09-30 | 2015-06-30 | 2015-03-31 | 2014-12-31 | 2014-09-30 | 2014-06-30 | 2014-03-31 | 2013-12-31 | 2013-09-30 | 2013-06-30 | 2013-03-31 | 2012-12-31 | 2012-09-30 | 2012-06-30 | 2012-03-31 | 2011-12-31 | 2011-09-30 | 2011-06-30 | 2011-03-31 | 2010-12-31 | 2010-09-30 | 2010-06-30 | 2010-03-31 | 2009-12-31 | 2009-09-30 | 2009-06-30 | 2009-03-31 | 2008-12-31 | 2008-09-30 | 2008-06-30 | 2008-03-31 | 2007-12-31 | 2007-09-30 | 2007-06-30 | 2007-03-31 | 2006-12-31 | 2006-09-30 | 2006-06-30 | 2006-03-31 | 2005-12-31 | 2005-09-30 | 2005-06-30 | 2005-03-31 | 2004-12-31 | 2004-09-30 | 2004-06-30 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
assets | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current assets: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents | 160,247,000 | 99,101,000 | 51,720,000 | 95,883,000 | 119,332,000 | 112,501,000 | 132,033,000 | 150,279,000 | 154,511,000 | 226,823,000 | 174,350,000 | 202,004,000 | 198,576,000 | 249,091,000 | 179,421,000 | 436,189,000 | 246,351,000 | 129,608,000 | 79,055,000 | 32,073,000 | 32,688,000 | 60,485,000 | 37,899,000 | 39,884,000 | 37,297,000 | 34,225,000 | 112,133,000 | 49,348,000 | 38,712,000 | 28,726,000 | 36,067,000 | 26,584,000 | 20,096,000 | 37,675,000 | 21,472,000 | 24,289,000 | 23,021,000 | 24,787,000 | 38,858,000 | 44,812,000 | 103,031,000 | 36,486,000 | 14,713,000 | 49,511,000 | 19,656,000 | 17,032,000 | 26,750,000 | 23,122,000 | 12,191,000 | 17,585,000 | 25,016,000 | 7,599,000 | 24,650,000 | 34,530,000 | 19,753,000 | 31,941,000 | 19,072,000 | 27,479,000 | 20,971,000 | 22,453,000 | 28,209,000 | 29,053,000 | 30,080,000 | 36,720,000 | 24,735,000 | 23,759,000 | 22,920,000 | 28,103,000 | 22,618,000 | 14,870,000 | 15,858,000 | 14,293,000 | 14,642,000 | 6,503,000 | 12,979,000 | 14,154,000 | 15,951,000 | 10,090,000 | 16,842,000 | 8,725,000 | 19,168,000 | 5,116,000 | 11,401,000 | 16,590,000 | 71,514,000 | 73,959,000 |
marketable securities available-for-sale | 487,568,000 | 514,628,000 | 609,616,000 | 617,951,000 | 644,660,000 | 623,111,000 | 591,505,000 | 592,023,000 | 565,905,000 | 454,702,000 | 477,606,000 | 422,391,000 | 387,910,000 | 269,078,000 | 323,795,000 | 109,761,000 | 167,804,000 | 216,196,000 | 153,619,000 | 132,963,000 | 144,473,000 | 140,223,000 | 91,634,000 | 111,171,000 | 137,649,000 | 106,269,000 | 71,083,000 | 96,188,000 | 141,509,000 | 187,317,000 | 214,713,000 | 165,270,000 | 171,584,000 | 89,286,000 | 63,884,000 | 57,126,000 | 86,530,000 | 114,202,000 | 127,989,000 | 151,313,000 | 117,666,000 | 56,895,000 | 82,881,000 | 73,141,000 | 110,916,000 | 137,281,000 | 150,929,000 | 166,254,000 | 64,283,000 | 71,576,000 | 80,357,000 | 117,531,000 | 123,629,000 | 125,669,000 | 87,128,000 | 14,958,000 | 20,216,000 | 27,828,000 | 21,279,000 | 40,977,000 | 49,744,000 | |||||||||||||||||||||||||
accounts receivables, net of allowance for doubtful accounts of 0 and 12,313 at september 30, 2025 and december 31, 2024, respectively | 72,359,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other receivables | 962,000 | 2,646,000 | 1,632,000 | 1,625,000 | 1,943,000 | 976,000 | 1,993,000 | 3,926,000 | 519,000 | 2,108,000 | 3,128,000 | 2,385,000 | 1,346,000 | 1,972,000 | 2,968,000 | 15,600,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
inventories | 73,288,000 | 75,687,000 | 74,403,000 | 70,054,000 | 62,402,000 | 62,462,000 | 61,806,000 | 53,290,000 | 49,412,000 | 53,088,000 | 57,693,000 | 59,446,000 | 102,609,000 | 73,979,000 | 79,038,000 | 61,335,000 | 67,297,000 | 86,451,000 | 68,846,000 | 63,689,000 | 59,033,000 | 54,392,000 | 48,099,000 | 41,332,000 | 39,356,000 | 36,629,000 | 27,569,000 | 19,022,000 | 12,452,000 | 5,112,000 | 550,000 | 312,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
prepaid expenses and other current assets | 19,907,000 | 22,951,000 | 23,674,000 | 18,147,000 | 24,570,000 | 21,308,000 | 19,788,000 | 18,995,000 | 18,972,000 | 17,494,000 | 15,626,000 | 85,629,000 | 100,004,000 | 134,538,000 | 82,995,000 | 73,764,000 | 61,093,000 | 9,453,000 | 9,377,000 | 9,206,000 | 18,786,000 | 9,463,000 | 8,380,000 | 7,380,000 | 5,711,000 | 6,745,000 | 5,948,000 | 6,102,000 | 4,604,000 | 3,883,000 | 3,303,000 | 3,697,000 | 4,633,000 | 4,434,000 | 2,831,000 | 6,842,000 | 5,673,000 | 6,273,000 | 2,728,000 | 2,427,000 | 2,489,000 | 3,858,000 | 3,478,000 | 4,058,000 | 3,578,000 | 4,978,000 | 2,323,000 | 1,375,000 | 1,120,000 | 1,241,000 | 1,217,000 | 2,052,000 | 2,419,000 | 4,145,000 | 1,868,000 | 1,130,000 | 1,393,000 | 1,788,000 | 1,515,000 | 1,360,000 | 1,079,000 | 817,000 | 802,000 | 586,000 | 1,008,000 | 1,231,000 | 1,098,000 | 991,000 | 1,351,000 | 5,138,000 | 5,205,000 | 6,049,000 | 3,529,000 | 1,760,000 | 1,682,000 | 673,000 | 1,117,000 | 1,275,000 | 2,704,000 | 1,277,000 | 1,806,000 | 2,136,000 | 2,117,000 | 1,396,000 | 1,043,000 | 930,000 |
total current assets | 814,331,000 | 785,712,000 | 815,970,000 | 848,941,000 | 926,241,000 | 882,012,000 | 851,286,000 | 859,120,000 | 835,666,000 | 797,460,000 | 830,141,000 | 916,985,000 | 932,944,000 | 955,405,000 | 940,515,000 | 972,520,000 | 852,670,000 | 583,906,000 | 427,533,000 | 290,015,000 | 290,003,000 | 265,466,000 | 194,147,000 | 208,653,000 | 228,835,000 | 191,450,000 | 222,524,000 | 174,364,000 | 198,784,000 | 226,342,000 | 255,396,000 | 198,023,000 | 197,096,000 | 132,205,000 | 89,652,000 | 89,599,000 | 117,514,000 | 147,126,000 | 170,739,000 | 199,946,000 | 224,349,000 | 97,896,000 | 101,981,000 | 127,437,000 | 134,877,000 | 160,583,000 | 181,732,000 | 192,378,000 | 79,753,000 | 92,427,000 | 108,137,000 | 128,187,000 | 154,383,000 | 165,628,000 | 110,124,000 | 124,618,000 | 55,397,000 | 64,651,000 | 55,845,000 | 74,515,000 | 50,224,000 | 60,177,000 | 32,690,000 | 38,882,000 | 49,301,000 | 56,457,000 | 65,218,000 | 76,542,000 | 72,502,000 | 77,009,000 | 85,167,000 | 101,939,000 | 73,499,000 | 86,096,000 | 74,886,000 | 89,686,000 | 62,331,000 | 63,140,000 | 71,024,000 | 77,484,000 | 54,004,000 | 61,522,000 | 68,906,000 | 70,779,000 | 76,509,000 | 79,538,000 |
property and equipment | 45,855,000 | 45,610,000 | 43,272,000 | 39,001,000 | 37,420,000 | 36,105,000 | 36,413,000 | 37,297,000 | 36,183,000 | 37,442,000 | 38,159,000 | 37,596,000 | 35,352,000 | 36,286,000 | 36,407,000 | 35,020,000 | 34,251,000 | 32,547,000 | 30,696,000 | 30,567,000 | 30,379,000 | 30,476,000 | 30,897,000 | 32,022,000 | 31,461,000 | 34,393,000 | 25,305,000 | 17,064,000 | 16,933,000 | 16,240,000 | 17,064,000 | 16,619,000 | 16,622,000 | 16,751,000 | 16,633,000 | 17,174,000 | 18,739,000 | 17,448,000 | 15,894,000 | 13,804,000 | 11,606,000 | 8,887,000 | 7,528,000 | 7,924,000 | 8,129,000 | 8,789,000 | 8,584,000 | 8,706,000 | 8,454,000 | 8,038,000 | 7,972,000 | 7,965,000 | 6,948,000 | 6,833,000 | 6,962,000 | 6,163,000 | 6,127,000 | 6,570,000 | 6,516,000 | 6,404,000 | 6,634,000 | 6,324,000 | 7,199,000 | 7,997,000 | 8,507,000 | 8,610,000 | 8,600,000 | 9,510,000 | 10,241,000 | 11,165,000 | 10,268,000 | 7,314,000 | 6,380,000 | 6,040,000 | 5,552,000 | 5,200,000 | 4,918,000 | 4,986,000 | 2,035,000 | 2,197,000 | 2,286,000 | 2,405,000 | 2,344,000 | 2,465,000 | 2,157,000 | 1,065,000 |
operating lease right-of-use assets | 19,904,000 | 20,314,000 | 20,869,000 | 21,608,000 | 21,780,000 | 22,526,000 | 23,392,000 | 24,287,000 | 24,949,000 | 25,366,000 | 25,433,000 | 25,745,000 | 25,680,000 | 25,785,000 | 26,310,000 | 25,964,000 | 26,772,000 | 25,164,000 | 25,799,000 | 26,583,000 | 27,353,000 | 27,871,000 | 28,436,000 | 30,252,000 | 29,723,000 | 29,533,000 | 33,505,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
goodwill | 2,199,000 | 2,200,000 | 2,027,000 | 1,946,000 | 2,091,000 | 2,007,000 | 2,022,000 | 2,067,000 | 1,981,000 | 2,039,000 | 2,038,000 | 2,006,000 | 1,835,000 | 1,958,000 | 2,082,000 | 2,125,000 | 2,171,000 | 2,225,000 | 2,197,000 | 2,297,000 | 2,196,000 | 2,103,000 | 2,061,000 | 2,081,000 | 2,045,000 | 2,131,000 | 2,102,000 | 2,144,000 | 2,174,000 | 2,189,000 | 2,309,000 | 2,244,000 | 2,213,000 | 2,140,000 | 2,001,000 | 1,971,000 | 2,100,000 | 2,080,000 | 2,127,000 | 2,043,000 | 2,106,000 | 2,078,000 | 2,032,000 | 2,277,000 | 2,376,000 | 2,557,000 | 2,576,000 | 2,579,000 | 2,532,000 | 2,436,000 | 2,400,000 | 2,475,000 | 2,408,000 | 2,356,000 | 2,498,000 | 2,312,000 | 2,312,000 | 2,312,000 | 2,312,000 | 2,312,000 | 2,312,000 | 2,312,000 | 2,312,000 | 2,312,000 | 2,312,000 | 2,312,000 | 2,312,000 | 2,312,000 | 2,312,000 | 2,312,000 | 2,312,000 | 2,312,000 | 2,312,000 | 2,312,000 | 2,312,000 | 2,312,000 | 2,312,000 | 2,312,000 | ||||||||
other assets, net of allowance for doubtful accounts of 10,970 at september 30, 2025 | 64,217,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total assets | 946,506,000 | 918,449,000 | 945,928,000 | 986,256,000 | 1,061,990,000 | 1,016,321,000 | 986,565,000 | 997,096,000 | 972,933,000 | 936,432,000 | 969,922,000 | 985,850,000 | 999,337,000 | 1,022,999,000 | 1,008,975,000 | 1,039,246,000 | 919,711,000 | 647,909,000 | 490,119,000 | 353,272,000 | 353,395,000 | 329,314,000 | 259,256,000 | 279,068,000 | 301,015,000 | 267,081,000 | 296,600,000 | 210,884,000 | 236,388,000 | 263,863,000 | 295,333,000 | 218,785,000 | 217,827,000 | 151,968,000 | 110,132,000 | 109,680,000 | 139,298,000 | 167,613,000 | 189,644,000 | 216,633,000 | 238,907,000 | 109,494,000 | 112,169,000 | 138,290,000 | 146,896,000 | 173,465,000 | 193,585,000 | 204,622,000 | 91,698,000 | 104,012,000 | 119,621,000 | 139,752,000 | 164,822,000 | 175,895,000 | 120,676,000 | 134,102,000 | 64,719,000 | 74,430,000 | 65,507,000 | 84,249,000 | 61,790,000 | 71,678,000 | 44,284,000 | 50,470,000 | 61,644,000 | 69,148,000 | 78,144,000 | 90,623,000 | 87,559,000 | 96,938,000 | 105,332,000 | 120,449,000 | 87,996,000 | 98,482,000 | 87,033,000 | 102,890,000 | 75,498,000 | 76,624,000 | 73,471,000 | 80,093,000 | 56,702,000 | 64,339,000 | 71,250,000 | 73,646,000 | 79,073,000 | 81,014,000 |
liabilities and stockholders’ equity | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current liabilities: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts payable | 3,948,000 | 2,702,000 | 4,330,000 | 9,061,000 | 7,089,000 | 4,555,000 | 2,431,000 | 5,245,000 | 3,120,000 | 3,246,000 | 7,296,000 | 3,211,000 | 3,050,000 | 4,959,000 | 20,194,000 | 2,600,000 | 3,596,000 | 12,079,000 | 3,154,000 | 3,312,000 | 5,273,000 | 2,695,000 | 4,557,000 | 9,278,000 | 7,660,000 | 11,226,000 | 11,868,000 | 5,278,000 | 4,089,000 | 3,314,000 | 2,279,000 | 4,539,000 | 2,243,000 | 681,000 | 1,466,000 | 3,796,000 | 3,795,000 | 4,486,000 | 3,476,000 | 3,433,000 | 2,359,000 | 2,345,000 | 3,272,000 | 1,159,000 | 4,972,000 | 1,900,000 | 1,863,000 | 1,901,000 | 1,289,000 | 1,253,000 | 1,727,000 | 2,166,000 | 1,578,000 | 1,155,000 | 2,358,000 | 2,040,000 | 1,313,000 | 1,742,000 | 1,880,000 | 2,329,000 | 2,067,000 | 1,033,000 | 1,091,000 | 1,686,000 | 1,037,000 | 1,222,000 | 1,088,000 | 905,000 | 1,130,000 | 1,379,000 | 2,764,000 | 4,418,000 | 1,951,000 | 3,405,000 | 1,564,000 | 2,181,000 | 3,108,000 | 1,417,000 | 896,000 | 952,000 | 2,259,000 | 1,620,000 | 729,000 | 1,391,000 | 2,059,000 | 2,161,000 |
accrued research and development | 6,697,000 | 5,459,000 | 5,654,000 | 4,310,000 | 4,402,000 | 4,581,000 | 3,137,000 | 2,982,000 | 3,290,000 | 3,594,000 | 5,155,000 | 4,775,000 | 4,300,000 | 3,678,000 | 6,359,000 | 4,688,000 | 3,935,000 | 4,167,000 | 2,890,000 | 2,805,000 | 2,939,000 | 2,396,000 | 3,253,000 | 4,120,000 | 4,242,000 | 5,501,000 | 9,630,000 | 9,714,000 | 6,003,000 | 4,121,000 | 4,443,000 | 4,359,000 | 3,079,000 | 3,223,000 | 4,305,000 | 5,048,000 | 4,702,000 | 5,273,000 | 6,027,000 | 7,361,000 | 7,861,000 | 5,927,000 | 7,346,000 | 6,938,000 | 6,801,000 | 6,720,000 | ||||||||||||||||||||||||||||||||||||||||
accrued liabilities | 51,889,000 | 65,952,000 | 54,292,000 | 61,066,000 | 54,102,000 | 48,488,000 | 45,841,000 | 49,448,000 | 43,462,000 | 33,872,000 | 27,833,000 | 30,719,000 | 38,209,000 | 34,146,000 | 16,108,000 | 49,796,000 | 87,910,000 | 25,711,000 | 16,083,000 | 19,099,000 | 17,192,000 | 13,181,000 | 12,268,000 | 14,802,000 | 17,003,000 | 19,550,000 | 12,384,000 | 16,041,000 | 14,506,000 | 11,087,000 | 9,820,000 | 9,695,000 | 7,567,000 | 7,184,000 | 6,607,000 | 11,192,000 | 21,988,000 | 18,464,000 | 13,251,000 | 15,337,000 | 5,952,000 | 4,746,000 | 3,593,000 | 6,317,000 | 6,608,000 | 8,166,000 | 8,148,000 | 7,307,000 | 8,166,000 | 10,063,000 | 9,163,000 | 7,340,000 | 6,301,000 | 8,159,000 | 7,316,000 | 7,113,000 | 8,158,000 | 10,943,000 | 17,530,000 | 14,644,000 | 10,571,000 | 7,507,000 | 7,356,000 | 6,682,000 | 6,878,000 | 6,816,000 | 11,976,000 | 10,381,000 | 10,267,000 | 12,059,000 | 11,075,000 | 9,636,000 | 9,788,000 | 10,742,000 | 6,930,000 | 6,195,000 | 4,709,000 | 3,841,000 | 3,910,000 | 4,549,000 | 4,240,000 | 4,371,000 | 4,885,000 | 3,235,000 | ||
convertible notes, current portion, net of debt discount of 135 at september 30, 2025 | 40,073,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other current liabilities | 4,232,000 | 4,097,000 | 4,103,000 | 4,197,000 | 4,437,000 | 4,568,000 | 4,593,000 | 4,520,000 | 4,392,000 | 4,150,000 | 3,830,000 | 3,631,000 | 3,388,000 | 3,047,000 | 2,969,000 | 2,590,000 | 2,889,000 | 3,489,000 | 3,356,000 | 3,247,000 | 8,849,000 | 3,045,000 | 2,951,000 | 9,987,000 | 9,849,000 | 8,296,000 | 8,369,000 | 7,000,000 | 7,000,000 | 7,000,000 | 7,000,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
total current liabilities | 106,839,000 | 118,230,000 | 68,379,000 | 78,634,000 | 70,030,000 | 62,192,000 | 56,002,000 | 62,195,000 | 54,264,000 | 44,862,000 | 91,515,000 | 150,074,000 | 244,080,000 | 345,198,000 | 466,203,000 | 556,402,000 | 528,935,000 | 204,642,000 | 109,422,000 | 77,411,000 | 66,625,000 | 53,222,000 | 29,279,000 | 53,047,000 | 46,348,000 | 44,573,000 | 42,251,000 | 38,033,000 | 31,598,000 | 25,522,000 | 23,542,000 | 18,593,000 | 12,889,000 | 11,088,000 | 12,378,000 | 20,036,000 | 30,485,000 | 28,223,000 | 24,513,000 | 28,785,000 | 19,730,000 | 21,964,000 | 20,499,000 | 20,279,000 | 22,820,000 | 20,183,000 | 15,982,000 | 16,192,000 | 15,563,000 | 14,906,000 | 17,060,000 | 19,014,000 | 29,365,000 | 25,259,000 | 25,817,000 | 27,219,000 | 10,058,000 | 10,284,000 | 11,467,000 | 14,701,000 | 21,026,000 | 29,135,000 | 16,361,000 | 14,478,000 | 11,520,000 | 11,576,000 | 24,120,000 | 40,854,000 | 19,890,000 | 15,442,000 | 16,547,000 | 19,904,000 | 13,807,000 | 13,589,000 | 12,100,000 | 13,701,000 | 11,465,000 | 8,441,000 | 6,355,000 | 5,543,000 | 6,169,000 | 6,217,000 | 4,969,000 | 6,762,000 | 8,694,000 | 7,146,000 |
convertible notes, net of debt discount of 4,034 and 1,646 at september 30, 2025 and december 31, 2024, respectively | 220,966,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term portion of lease liabilities | 23,985,000 | 24,726,000 | 25,521,000 | 26,388,000 | 26,607,000 | 27,473,000 | 28,559,000 | 29,720,000 | 30,680,000 | 31,545,000 | 32,131,000 | 32,801,000 | 33,127,000 | 33,677,000 | 34,253,000 | 34,316,000 | 34,929,000 | 32,897,000 | 33,795,000 | 34,789,000 | 35,519,000 | 36,231,000 | 36,972,000 | 37,845,000 | 36,964,000 | 34,641,000 | 35,076,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cepi accrual long-term | 60,337,000 | 60,337,000 | 60,337,000 | 60,337,000 | 60,337,000 | 60,337,000 | 60,337,000 | 60,337,000 | 60,337,000 | 60,337,000 | 60,337,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other long-term liabilities | 241,000 | 242,000 | 243,000 | 244,000 | 28,000 | 198,000 | 203,000 | 74,000 | 321,000 | 349,000 | 352,000 | 384,000 | 251,000 | 295,000 | 276,000 | 5,664,000 | 79,000 | 81,000 | 2,901,000 | 2,568,000 | 2,234,000 | 1,910,000 | 1,598,000 | 1,285,000 | 932,000 | 643,000 | 441,000 | 8,915,000 | 7,458,000 | 7,257,000 | 6,672,000 | 643,000 | 504,000 | 353,000 | 358,000 | 443,000 | 541,000 | 620,000 | 700,000 | 769,000 | 1,001,000 | 1,125,000 | 1,085,000 | 1,070,000 | 1,645,000 | 902,000 | 927,000 | 963,000 | 988,000 | 627,000 | 621,000 | 629,000 | 624,000 | 616,000 | 631,000 | 617,000 | 630,000 | 60,000 | 65,000 | 146,000 | 151,000 | 160,000 | 166,000 | 117,000 | 101,000 | 106,000 | 7,611,000 | 7,616,000 | 5,622,000 | 3,627,000 | 82,000 | 99,000 | 117,000 | 135,000 | 152,000 | 170,000 | 187,000 | 205,000 | 222,000 | 240,000 | 258,000 | |||||
total liabilities | 412,368,000 | 424,287,000 | 414,987,000 | 389,457,000 | 380,563,000 | 373,472,000 | 368,085,000 | 375,024,000 | 368,017,000 | 359,227,000 | 406,190,000 | 404,837,000 | 498,761,000 | 600,200,000 | 721,491,000 | 816,872,000 | 852,135,000 | 564,529,000 | 390,357,000 | 294,579,000 | 284,111,000 | 271,019,000 | 247,432,000 | 270,778,000 | 261,859,000 | 256,493,000 | 253,441,000 | 147,819,000 | 139,375,000 | 132,550,000 | 129,446,000 | 19,236,000 | 13,393,000 | 11,441,000 | 12,736,000 | 20,479,000 | 31,026,000 | 28,843,000 | 25,213,000 | 29,554,000 | 27,719,000 | 34,966,000 | 37,096,000 | 37,808,000 | 25,320,000 | 22,795,000 | 19,732,000 | 18,328,000 | 19,302,000 | 19,353,000 | 21,694,000 | 24,926,000 | 34,764,000 | |||||||||||||||||||||||||||||||||
commitments and contingencies | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stockholders’ equity: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock: 0.001 par value... | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
common stock: 0.001 par value... | 117,000 | 117,000 | 124,000 | 125,000 | 131,000 | 131,000 | 131,000 | 130,000 | 129,000 | 129,000 | 128,000 | 128,000 | 127,000 | 126,000 | 126,000 | 123,000 | 120,000 | 114,000 | 114,000 | 110,000 | 110,000 | 109,000 | 88,000 | 84,000 | 84,000 | 65,000 | 65,000 | 63,000 | 63,000 | 63,000 | 62,000 | 62,000 | 61,000 | 55,000 | 45,000 | 39,000 | 39,000 | 38,000 | 38,000 | 38,000 | 38,000 | 30,000 | 29,000 | 26,000 | 263,000 | 183,000 | 183,000 | 183,000 | 183,000 | 178,000 | 178,000 | 157,000 | 155,000 | 126,000 | 123,000 | 116,000 | 116,000 | 88,000 | 87,000 | 55,000 | 54,000 | 41,000 | 40,000 | 40,000 | 40,000 | 40,000 | 40,000 | 40,000 | 40,000 | 40,000 | 40,000 | 40,000 | 40,000 | 31,000 | 31,000 | 30,000 | 25,000 | 25,000 | 25,000 | 25,000 | 25,000 | |||||
additional paid-in capital | 1,486,947,000 | 1,474,046,000 | 1,532,835,000 | 1,504,671,000 | 1,591,107,000 | 1,575,548,000 | 1,562,027,000 | 1,554,634,000 | 1,541,549,000 | 1,527,544,000 | 1,516,331,000 | 1,510,518,000 | 1,501,639,000 | 1,484,970,000 | 1,476,013,000 | 1,441,868,000 | 1,386,114,000 | 1,372,679,000 | 1,393,947,000 | 1,352,374,000 | 1,348,793,000 | 1,343,279,000 | 1,245,730,000 | 1,229,417,000 | 1,224,228,000 | 1,161,115,000 | 1,151,421,000 | 1,131,241,000 | 1,124,892,000 | 1,118,487,000 | 1,112,321,000 | 1,107,693,000 | 1,085,433,000 | 1,000,177,000 | 938,159,000 | 904,957,000 | 901,075,000 | 897,027,000 | 893,278,000 | 889,698,000 | 886,575,000 | 719,966,000 | 697,149,000 | 695,058,000 | 693,066,000 | 691,419,000 | 689,729,000 | 688,390,000 | 561,687,000 | 558,766,000 | 555,010,000 | 550,729,000 | 545,767,000 | 542,934,000 | 470,849,000 | 466,276,000 | 397,996,000 | 391,925,000 | 372,105,000 | 369,686,000 | 325,492,000 | 310,756,000 | 267,583,000 | 266,127,000 | 267,115,000 | 263,806,000 | 263,135,000 | 262,579,000 | 261,862,000 | 259,843,000 | 259,068,000 | 258,266,000 | 250,770,000 | 246,358,000 | 245,669,000 | 244,787,000 | 198,809,000 | 197,620,000 | 191,099,000 | 192,840,000 | 159,173,000 | 159,126,000 | 159,120,000 | 159,074,000 | 158,691,000 | 158,473,000 |
accumulated other comprehensive income | 800,000 | 652,000 | 514,000 | -168,000 | -794,000 | -354,000 | -258,000 | 353,000 | 502,000 | 398,000 | 248,000 | 187,000 | 158,000 | 172,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accumulated deficit | -953,726,000 | -980,653,000 | -999,374,000 | -903,275,000 | -910,325,000 | -927,919,000 | -939,305,000 | -930,584,000 | -930,803,000 | -945,096,000 | -948,527,000 | -924,195,000 | -991,928,000 | -1,055,737,000 | -1,184,492,000 | -1,217,351,000 | -1,317,130,000 | -1,288,700,000 | -1,293,173,000 | -1,294,064,000 | -1,278,597,000 | -1,282,998,000 | -1,231,419,000 | -1,218,824,000 | -1,182,068,000 | -1,148,609,000 | -1,105,896,000 | -1,066,224,000 | -1,026,255,000 | -985,727,000 | -946,283,000 | -907,325,000 | -879,904,000 | -857,776,000 | -837,458,000 | -812,171,000 | -790,430,000 | -755,736,000 | -726,750,000 | -699,727,000 | -672,865,000 | -642,741,000 | -619,150,000 | -592,933,000 | -570,647,000 | -540,828,000 | -516,051,000 | -502,211,000 | -489,155,000 | -473,480,000 | -456,316,000 | -435,491,000 | -414,948,000 | -397,157,000 | -382,047,000 | -365,542,000 | -361,275,000 | -346,046,000 | -335,411,000 | -316,945,000 | -301,823,000 | -296,825,000 | -268,821,000 | -259,637,000 | -249,038,000 | -239,532,000 | -243,642,000 | -248,743,000 | -251,842,000 | -246,422,000 | -240,343,000 | -227,914,000 | -215,838,000 | -198,737,000 | -181,033,000 | -167,943,000 | -151,488,000 | -139,336,000 | -124,063,000 | -115,891,000 | -107,129,000 | -98,845,000 | -90,266,000 | -95,336,000 | -90,173,000 | -86,140,000 |
total stockholders’ equity | 534,138,000 | 494,162,000 | 530,941,000 | 596,799,000 | 681,427,000 | 642,849,000 | 618,480,000 | 622,072,000 | 604,916,000 | 577,205,000 | 563,732,000 | 581,013,000 | 500,576,000 | 422,799,000 | 287,484,000 | 222,374,000 | 67,576,000 | 83,380,000 | 99,762,000 | 58,693,000 | 69,284,000 | 58,295,000 | 11,824,000 | 8,290,000 | 39,156,000 | 10,588,000 | 43,159,000 | 63,065,000 | 97,013,000 | 131,313,000 | 165,887,000 | 199,549,000 | 204,434,000 | 140,527,000 | 97,396,000 | 89,201,000 | 108,272,000 | 138,770,000 | 164,431,000 | 187,079,000 | 211,188,000 | 74,528,000 | 75,073,000 | 100,482,000 | 121,576,000 | 150,670,000 | 173,853,000 | 186,294,000 | 72,396,000 | 84,659,000 | 97,927,000 | 114,826,000 | 130,058,000 | 144,708,000 | 88,379,000 | 99,880,000 | 36,229,000 | 45,830,000 | 36,495,000 | 52,111,000 | 23,208,000 | 12,808,000 | -1,799,000 | 6,376,000 | 17,524,000 | 24,608,000 | 20,364,000 | 13,522,000 | 9,802,000 | 13,814,000 | 19,267,000 | 30,790,000 | 35,220,000 | 47,848,000 | 64,834,000 | 77,056,000 | 47,441,000 | 58,303,000 | 66,946,000 | 74,363,000 | 49,578,000 | 57,150,000 | 65,291,000 | 59,876,000 | 64,129,000 | 67,368,000 |
total liabilities and stockholders’ equity | 946,506,000 | 918,449,000 | 945,928,000 | 986,256,000 | 1,061,990,000 | 1,016,321,000 | 986,565,000 | 997,096,000 | 972,933,000 | 936,432,000 | 969,922,000 | 985,850,000 | 999,337,000 | 1,022,999,000 | 1,008,975,000 | 1,039,246,000 | 919,711,000 | 647,909,000 | 490,119,000 | 353,272,000 | 353,395,000 | 329,314,000 | 259,256,000 | 279,068,000 | 301,015,000 | 267,081,000 | 296,600,000 | 210,884,000 | 236,388,000 | 263,863,000 | 295,333,000 | 218,785,000 | 217,827,000 | 151,968,000 | 110,132,000 | 109,680,000 | 139,298,000 | 167,613,000 | 189,644,000 | 216,633,000 | 238,907,000 | 109,494,000 | 112,169,000 | 138,290,000 | 146,896,000 | 173,465,000 | 193,585,000 | 204,622,000 | 91,698,000 | 104,012,000 | 119,621,000 | 139,752,000 | 164,822,000 | 175,895,000 | 120,676,000 | 134,102,000 | 64,719,000 | 74,430,000 | 65,507,000 | 84,249,000 | 61,790,000 | 71,678,000 | 44,284,000 | 50,470,000 | 61,644,000 | 69,148,000 | 78,144,000 | 102,890,000 | 73,471,000 | 80,093,000 | 56,702,000 | 64,339,000 | 71,250,000 | |||||||||||||
accounts receivables, net of allowance for doubtful accounts of 12,313 at june 30, 2025 and december 31, 2024, respectively | 70,699,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other assets, net of allowance for doubtful accounts of 10,970 at june 30, 2025 | 64,613,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible notes, current portion, net of debt discount of 188 at june 30, 2025 | 40,020,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible notes, net of debt discount of 4,248 and 1,646 at june 30, 2025 and december 31, 2024, respectively | 220,752,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts receivables, net of allowance for doubtful accounts of 12,313 at march 31, 2025 and december 31, 2024, respectively | 54,925,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other assets, net of allowance for doubtful accounts of 10,970 at march 31, 2025 | 63,790,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible notes, net of debt discount of 4,701 and 1,646 at march 31, 2025 and december 31, 2024, respectively | 260,507,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accumulated other comprehensive loss | -2,644,000 | -4,722,000 | -4,911,000 | -4,373,000 | -2,108,000 | -5,959,000 | -5,372,000 | -4,200,000 | -5,438,000 | -9,262,000 | -6,560,000 | -4,163,000 | -1,022,000 | -2,095,000 | -2,575,000 | -2,387,000 | -3,088,000 | -1,983,000 | -2,431,000 | -2,015,000 | -1,687,000 | -1,510,000 | -213,000 | -881,000 | -1,156,000 | -1,929,000 | -3,350,000 | -3,624,000 | -2,412,000 | -2,559,000 | -2,135,000 | -2,930,000 | -2,560,000 | -2,727,000 | -2,955,000 | -1,669,000 | -1,106,000 | -184,000 | -549,000 | -1,210,000 | -616,000 | -36,000 | -348,000 | -12,000 | -120,000 | -102,000 | ||||||||||||||||||||||||||||||||||||||||
accounts receivables, net of allowance for doubtful accounts of 12,313 at december 31, 2024 and december 31, 2023, respectively | 45,281,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other assets | 74,760,000 | 74,458,000 | 73,671,000 | 73,452,000 | 74,325,000 | 74,154,000 | 73,915,000 | 73,941,000 | 3,311,000 | 3,337,000 | 3,363,000 | 3,447,000 | 3,398,000 | 3,623,000 | 3,838,000 | 3,668,000 | 3,573,000 | 3,238,000 | 3,181,000 | 3,301,000 | 3,344,000 | 3,509,000 | 1,799,000 | 3,104,000 | 4,976,000 | 3,834,000 | 2,104,000 | 1,267,000 | 1,270,000 | 1,270,000 | 253,000 | 1,241,000 | 334,000 | 330,000 | 346,000 | 267,000 | 231,000 | 231,000 | 20,000 | 20,000 | 20,000 | 872,000 | 876,000 | 31,000 | 297,000 | 302,000 | 463,000 | 468,000 | 473,000 | 438,000 | 438,000 | 438,000 | 362,000 | 224,000 | 224,000 | 112,000 | 67,000 | 2,076,000 | 2,076,000 | 1,049,000 | 3,703,000 | 4,591,000 | 5,645,000 | 2,178,000 | 155,000 | 153,000 | 1,310,000 | 1,304,000 | 1,302,000 | 412,000 | 412,000 | 412,000 | 412,000 | 402,000 | 407,000 | 411,000 | ||||||||||
convertible notes, net of debt discount of 1,646 and 2,802 at december 31, 2024 and december 31, 2023, respectively | 223,854,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts receivables, net of allowance for doubtful accounts of 12,313 at september 30, 2024 and december 31, 2023, respectively | 73,334,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible notes, net of debt discount of 1,939 and 2,802 at september 30, 2024 and december 31, 2023, respectively | 223,561,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts receivables, net of allowance for doubtful accounts of 12,313 at june 30, 2024 and december 31, 2023, respectively | 61,654,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible notes, net of debt discount of 2,228 and 2,802 at june 30, 2024 and december 31, 2023, respectively | 223,272,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts receivables, net of allowance for doubtful accounts of 12,313 at march 31, 2024 and december 31, 2023, respectively | 44,161,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible notes, net of debt discount of 2,516 and 2,802 at march 31, 2024 and december 31, 2023, respectively | 222,984,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts receivables, net of allowance for doubtful accounts of 12,313 and 0 at december 31, 2023 and december 31, 2022, respectively | 40,607,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cepi accrual | 47,401,000 | 107,738,000 | 107,738,000 | 107,370,000 | 107,370,000 | 128,848,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible notes, net of debt discount of 2,802 and 3,922 at december 31, 2023 and december 31, 2022, respectively | 222,698,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts receivables, net of allowance for doubtful accounts of 12,313 and 0 at september 30, 2023 and december 31, 2022, respectively | 46,347,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible notes, net of debt discount of 3,085 and 3,922 at september 30, 2023 and december 31, 2022, respectively | 222,415,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts receivables, net of allowance for doubtful accounts of 12,313 and 0 at june 30, 2023 and december 31, 2022, respectively | 43,245,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
restricted cash | 210,000 | 210,000 | 207,000 | 189,000 | 202,000 | 214,000 | 219,000 | 224,000 | 229,000 | 226,000 | 237,000 | 226,000 | 217,000 | 212,000 | 216,000 | 619,000 | 628,000 | 615,000 | 619,000 | 622,000 | 624,000 | 635,000 | 629,000 | 626,000 | 619,000 | 605,000 | 602,000 | 615,000 | 613,000 | 617,000 | 609,000 | 615,000 | 613,000 | 608,000 | 632,000 | 642,000 | 660,000 | 662,000 | 662,000 | 657,000 | 648,000 | 644,000 | 652,000 | 645,000 | 640,000 | 654,000 | 647,000 | 659,000 | 673,000 | 668,000 | 652,000 | 659,000 | 633,000 | 656,000 | 681,000 | 677,000 | 667,000 | 651,000 | 668,000 | 674,000 | 699,000 | 661,000 | 408,000 | 408,000 | 408,000 | 408,000 | 408,000 | 408,000 | 408,000 | 408,000 | 408,000 | 408,000 | 408,000 | 408,000 | 408,000 | 408,000 | 77,000 | |||||||||
convertible notes, net of debt discount of 3,366 and 3,922 at june 30, 2023 and december 31, 2022, respectively | 222,134,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts receivables, net of allowance for doubtful accounts of 12,313 and 0 at march 31, 2023 and december 31, 2022, respectively | 101,738,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible notes, net of debt discount of 3,645 and 3,922 at march 31, 2023 and december 31, 2022, respectively | 221,855,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts receivables | 145,130,000 | 129,772,000 | 172,270,000 | 133,968,000 | 116,216,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
prepaid manufacturing | 12,727,000 | 54,477,000 | 138,330,000 | 159,655,000 | 109,763,000 | 36,298,000 | 32,642,000 | 29,423,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
warrant liability | 18,016,000 | 72,017,000 | 29,639,000 | 31,737,000 | 10,736,000 | 10,660,000 | 31,905,000 | 6,250,000 | 14,860,000 | 7,594,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred revenue | 87,395,000 | 191,998,000 | 313,203,000 | 349,864,000 | 358,588,000 | 129,557,000 | 52,202,000 | 38,212,000 | 21,712,000 | 1,750,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible notes, net of debt discount of 3,922 and 5,010 at december 31, 2022 and december 31, 2021, respectively | 221,578,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible notes, net of debt discount of 4,197 and 5,010 at september 30, 2022, and december 31, 2021, respectively | 221,303,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible notes, net of debt discount of 4,470 and 5,010 at june 30, 2022 and december 31, 2021, respectively | 221,030,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible notes, net of debt discount of 4,741 and 5,010 at march 31, 2022 and december 31, 2021, respectively | 220,759,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term debt | 179,889,000 | 179,811,000 | 179,733,000 | 179,656,000 | 179,583,000 | 178,601,000 | 177,615,000 | 176,636,000 | 175,673,000 | 100,319,000 | 99,771,000 | 99,232,000 | 7,961,000 | 8,913,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible notes, net of debt discount of 5,010 at december 31, 2021 | 220,490,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock: 0.001 par value | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
authorized: 5,000 shares; issued and outstanding: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
series b convertible preferred stock — no shares and 4 shares at december 31, 2021 and 2020, respectively | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accumulated other comprehensive gain | -2,266,000 | -1,528,000 | -713,000 | -1,126,000 | 273,000 | 89,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts and other receivables | 200,362,000 | 105,900,000 | 83,994,000 | 22,661,000 | 35,023,000 | 903,000 | 8,135,000 | 8,886,000 | 8,822,000 | 7,582,000 | 5,791,000 | 3,704,000 | 1,507,000 | 1,304,000 | 763,000 | 854,000 | 783,000 | 810,000 | 1,465,000 | 1,342,000 | 2,290,000 | 1,864,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible notes, net of debt discount of 5,277 at september 30, 2021 | 220,223,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term deferred revenue | 67,969,000 | 106,950,000 | 64,350,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
series b convertible preferred stock ̶ no shares and 4 shares at september 30, 2021 and december 31, 2020, respectively | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible notes, net of debt discount of 5,541 at june 30, 2021 | 219,959,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
series b convertible preferred stock ̶ 4 shares at june 30, 2021 and december 31, 2020 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
series b convertible preferred stock ̶ 4 shares at march 31, 2021 and december 31, 2020 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
intangible assets | 202,000 | 2,500,000 | 4,823,000 | 7,147,000 | 9,445,000 | 11,717,000 | 14,041,000 | 16,364,000 | 18,662,000 | 1,306,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
series b convertible preferred stock — 4 shares and 5 shares at december 31, 2020 and 2019, respectively | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
series b convertible preferred stock ̶ 4 shares and 5 shares at september 30, 2020 and december 31, 2019, respectively | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
series b convertible preferred stock ̶ 4 shares and 5 shares at june 30, 2020 and december 31, 2019, respectively | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
series b convertible preferred stock ̶ 5 shares at march 31, 2020 and december 31, 2019 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
series b convertible preferred stock — 5 shares at december 31, 2019 and no shares at december 31, 2018 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
series b convertible preferred stock ̶ 5 shares at september 30, 2019 and no shares at december 31, 2018 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long term debt | 100,871,000 | 9,559,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred revenues | 1,759,000 | 2,654,000 | 3,558,000 | 7,448,000 | 5,694,000 | 5,865,000 | 5,644,000 | 6,584,000 | 7,511,000 | 6,125,000 | 6,126,000 | 6,346,000 | 7,167,000 | 6,785,000 | 4,172,000 | 2,859,000 | 3,801,000 | 4,210,000 | 1,429,000 | 1,429,000 | 1,429,000 | 1,429,000 | 1,429,000 | 1,429,000 | 2,384,000 | 2,718,000 | 3,127,000 | 3,672,000 | 16,154,000 | 33,133,000 | 6,784,000 | 3,682,000 | 3,516,000 | 3,427,000 | 781,000 | 548,000 | 748,000 | 778,000 | 1,427,000 | 829,000 | 750,000 | 750,000 | 48,000 | 1,000,000 | ||||||||||||||||||||||||||||||||||||||||||
accounts receivable | 1,164,000 | 1,394,000 | 1,163,000 | 657,000 | 909,000 | 727,000 | 727,000 | 1,292,000 | 1,730,000 | 1,627,000 | 2,159,000 | 2,025,000 | 1,547,000 | 1,005,000 | 3,685,000 | 1,284,000 | 1,375,000 | 9,527,000 | 783,000 | 1,139,000 | 1,127,000 | 1,001,000 | 1,255,000 | 1,349,000 | 1,152,000 | 895,000 | 1,184,000 | 1,519,000 | 2,978,000 | 6,407,000 | 6,216,000 | 8,057,000 | 6,140,000 | 7,234,000 | 574,000 | 1,102,000 | 1,218,000 | 2,154,000 | 1,885,000 | 710,000 | 421,000 | 689,000 | 1,061,000 | 744,000 | 8,957,000 | 3,131,000 | 3,544,000 | 4,572,000 | ||||||||||||||||||||||||||||||||||||||
deferred revenues, net of current portion | 6,988,000 | 3,916,000 | 6,599,000 | 6,900,000 | 855,000 | 1,710,000 | 2,823,000 | 1,173,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
series b convertible preferred stock — no shares at december 31, 2015 and 43 shares at december 31, 2014 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
series b convertible preferred stock — no shares and 43 shares issued and outstanding at september 30, 2015 and december 31, 2014, respectively | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term debt, current portion | 1,498,000 | 594,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
series b convertible preferred stock — 17 shares at june 30, 2015 and 43 at december 31, 2014 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
series b convertible preferred stock — 17 shares at march 31, 2015 and 43 at december 31, 2014 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
series b convertible preferred stock — 43 shares at december 31, 2014 and 2013 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other accrued liabilities | 5,403,000 | 4,979,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock: 0.001 par value: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
authorized: 5,000 shares | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
issued and outstanding: series b convertible preferred stock — 43 shares at september 30, 2014 and december 31, 2013 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
common stock: 0.001 par value: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
authorized: 350,000 shares | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
issued and outstanding: 262,934 shares at september 30, 2014 and 262,796 shares at december 31, 2013 | 263,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
issued and outstanding: series b convertible preferred stock — 43 shares at june 30, 2014 and december 31, 2013 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
issued and outstanding: 262,881 shares at june 30, 2014 and 262,796 shares at december 31, 2013 | 263,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
series b convertible preferred stock — 43 shares at march 31, 2014 and december 31, 2013 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
issued and outstanding: 262,856 shares at march 31, 2014 and 262,796 shares at december 31, 2013 | 263,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total accumulated other comprehensive loss | -88,000 | -148,000 | -319,000 | -810,000 | -950,000 | -595,000 | -939,000 | -1,247,000 | -580,000 | -1,009,000 | -618,000 | -172,000 | -315,000 | -746,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
series b convertible preferred stock — 43 shares at december 31, 2013 and zero shares at december 31, 2012 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred revenues, noncurrent | 2,751,000 | 3,820,000 | 4,013,000 | 5,283,000 | 4,775,000 | 5,312,000 | 5,849,000 | 6,386,000 | 4,583,000 | 4,940,000 | 5,298,000 | 5,655,000 | 6,012,000 | 16,369,000 | 16,726,000 | 17,083,000 | 17,440,000 | 17,798,000 | 18,543,000 | 18,512,000 | 39,188,000 | 39,785,000 | 40,127,000 | 40,792,000 | 10,000,000 | 10,000,000 | 10,000,000 | 10,000,000 | 10,000,000 | 750,000 | 750,000 | 750,000 | 6,750,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
accumulated other comprehensive loss: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
unrealized gain on marketable securities available-for-sale | 22,000 | 4,000 | 37,000 | 45,000 | 29,000 | -3,000 | 2,000 | 9,000 | -17,000 | 1,000 | 17,000 | 49,000 | 24,000 | 182,000 | 138,000 | 23,000 | 35,000 | 16,000 | 28,000 | 7,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cumulative translation adjustment | -341,000 | -814,000 | -987,000 | -640,000 | -968,000 | -1,217,000 | -577,000 | -1,006,000 | -612,000 | -174,000 | -324,000 | -729,000 | -552,000 | -1,220,000 | -616,000 | -168,000 | -36,000 | -349,000 | -811,000 | -403,000 | -273,000 | 329,000 | 320,000 | 260,000 | 225,000 | 152,000 | 142,000 | 144,000 | 82,000 | 60,000 | -5,000 | -4,000 | -4,000 | -4,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
note payable to symphony dynamo holdings llc | 14,452,000 | 13,905,000 | 13,357,000 | 12,810,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
dynavax stockholders’ equity: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
unrealized loss on marketable securities available-for-sale | -30,000 | -3,000 | -6,000 | -72,000 | -115,000 | -96,000 | -120,000 | -161,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
marketable securities | 82,020,000 | 34,149,000 | 34,245,000 | 32,232,000 | 49,701,000 | 19,022,000 | 28,325,000 | 6,509,000 | 13,783,000 | 15,264,000 | 42,324,000 | 58,677,000 | 25,243,000 | 31,613,000 | 50,649,000 | 31,561,000 | 53,118,000 | 46,023,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other intangible assets | 54,000 | 299,000 | 544,000 | 789,000 | 1,034,000 | 1,279,000 | 1,524,000 | 1,769,000 | 2,014,000 | 2,259,000 | 2,504,000 | 2,749,000 | 2,994,000 | 3,239,000 | 3,627,000 | 3,879,000 | 4,130,000 | 4,382,000 | 4,633,000 | 4,884,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term note payable to holdings | 10,939,000 | 10,540,000 | 10,140,000 | 9,741,000 | 9,342,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term contingent liability to holdings | 877,000 | 843,000 | 944,000 | 3,161,000 | 3,109,000 | 3,040,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term note payable to symphony dynamo holdings llc | 12,342,000 | 11,874,000 | 11,407,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term contingent liability to symphony dynamo holdings llc | 860,000 | 840,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other long-term accrued liabilities | 642,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
warrant liability to symphony dynamo holdings llc | 12,029,000 | 2,315,000 | 2,567,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
unrealized gain on marketable securities available for sale | 3,000 | 10,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
dynavax stockholders’ equity | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
investments held by symphony dynamo, inc. | 21,697,000 | 22,772,000 | 23,788,000 | 25,109,000 | 26,685,000 | 28,029,000 | 29,475,000 | 31,631,000 | 32,804,000 | 35,098,000 | 8,609,000 | 13,363,000 | 17,727,000 | 19,044,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liability from program option exercised under the sdi collaboration | 15,000,000 | 15,000,000 | 15,000,000 | 15,000,000 | 15,000,000 | 15,000,000 | 15,000,000 | 15,000,000 | 15,000,000 | 15,000,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accumulated other comprehensive income: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total dynavax stockholders’ equity | 6,376,000 | 18,082,000 | 23,966,000 | 18,739,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
noncontrolling interest in sdi | -558,000 | 642,000 | 1,625,000 | 2,634,000 | 3,573,000 | 5,286,000 | 6,775,000 | 8,341,000 | 10,342,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liabilities, noncontrolling interest and stockholders’ equity | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total liabilities, noncontrolling interest and stockholders’ equity | 90,623,000 | 87,559,000 | 96,938,000 | 105,332,000 | 120,449,000 | 87,996,000 | 98,482,000 | 87,033,000 | 75,498,000 | 76,624,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
unrealized gains on marketable securities available-for-sale | 15,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
inventory | 263,000 | 248,000 | 246,000 | 257,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
commitments and contingencies stockholders’ equity: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
noncontrolling interest in symphony dynamo, inc. | 11,963,000 | 2,016,000 | 6,457,000 | 9,728,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred stock compensation | -2,467,000 | -2,383,000 | -2,693,000 | -3,029,000 | -3,366,000 | -3,783,000 | -4,369,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accumulated other comprehensive gain: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
notes receivable from stockholders | -8,000 | -339,000 | -394,000 | -419,000 | -631,000 | -621,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liabilities, minority interest, convertible preferred stock, and stockholders’ equity | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
minority interest in dynavax asia | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible preferred stock: 0.001 par value... | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stockholders’ equity | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total liabilities, minority interest, convertible preferred stock, and stockholders’ equity | 73,646,000 | 79,073,000 | 81,014,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred revenue, noncurrent | 6,250,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of deferred revenue | 1,750,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
noncurrent portion of deferred revenue | 6,500,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible preferred stock |
Cashflow Statements:
Quarterly
Annual
| Unit: USD | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2017-12-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | 2016-12-31 | 2016-09-30 | 2016-06-30 | 2016-03-31 | 2015-12-31 | 2015-09-30 | 2015-06-30 | 2015-03-31 | 2014-12-31 | 2014-09-30 | 2014-06-30 | 2014-03-31 | 2013-12-31 | 2013-09-30 | 2013-06-30 | 2013-03-31 | 2012-12-31 | 2012-09-30 | 2012-06-30 | 2012-03-31 | 2011-12-31 | 2011-09-30 | 2011-06-30 | 2011-03-31 | 2010-12-31 | 2010-09-30 | 2010-06-30 | 2010-03-31 | 2009-12-31 | 2009-09-30 | 2009-06-30 | 2009-03-31 | 2008-12-31 | 2008-09-30 | 2008-06-30 | 2008-03-31 | 2007-12-31 | 2007-09-30 | 2007-06-30 | 2007-03-31 | 2006-12-31 | 2006-09-30 | 2006-06-30 | 2006-03-31 | 2005-12-31 | 2005-09-30 | 2005-06-30 | 2005-03-31 | 2004-12-31 | 2004-09-30 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
operating activities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net income | 26,927,000 | 7,050,000 | 17,594,000 | 219,000 | 14,293,000 | 3,431,000 | -24,332,000 | 67,733,000 | 63,809,000 | 128,755,000 | 32,859,000 | 99,779,000 | -28,430,000 | 4,473,000 | 891,000 | -15,467,000 | 4,401,000 | -51,579,000 | -12,595,000 | -38,958,000 | -27,421,000 | -22,128,000 | -20,318,000 | -25,287,000 | -21,741,000 | -34,694,000 | -28,986,000 | -27,023,000 | -26,862,000 | -30,124,000 | -23,591,000 | -26,217,000 | -22,286,000 | -29,819,000 | -24,777,000 | -13,840,000 | -13,056,000 | -15,675,000 | -17,164,000 | -20,825,000 | -20,543,000 | -17,791,000 | -15,110,000 | -16,505,000 | -15,229,000 | -10,635,000 | -18,466,000 | 3,099,000 | -5,420,000 | -6,079,000 | -12,429,000 | -12,076,000 | -17,101,000 | -17,704,000 | -13,090,000 | -16,455,000 | -12,152,000 | -15,273,000 | -8,172,000 | -8,762,000 | -8,284,000 | -8,579,000 | 5,070,000 | -5,163,000 | -4,033,000 | ||||||||||||||||||||
adjustments to reconcile net income to net cash from operating activities: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
depreciation and amortization | 1,291,000 | 1,242,000 | 1,173,000 | 1,184,000 | 1,184,000 | 1,135,000 | 1,124,000 | 1,114,000 | 1,115,000 | 1,100,000 | 1,013,000 | 837,000 | 890,000 | 1,100,000 | 985,000 | 1,016,000 | 1,078,000 | 1,096,000 | 1,106,000 | 1,107,000 | 1,103,000 | 1,049,000 | 1,014,000 | 1,100,000 | 4,642,000 | 1,494,000 | 1,702,000 | 1,110,000 | 853,000 | 835,000 | 823,000 | 788,000 | 782,000 | 885,000 | 789,000 | 683,000 | 628,000 | 544,000 | 402,000 | 407,000 | 324,000 | 299,000 | 335,000 | 388,000 | 336,000 | 341,000 | 339,000 | 341,000 | 340,000 | 327,000 | 319,000 | 309,000 | 306,000 | 300,000 | 292,000 | 294,000 | 305,000 | 344,000 | 360,000 | 301,000 | 343,000 | 372,000 | 399,000 | 422,000 | 475,000 | 490,000 | 470,000 | 489,000 | 453,000 | 470,000 | 438,000 | 392,000 | 379,000 | 371,000 | 341,000 | 333,000 | 1,624,000 | -1,011,000 | 184,000 | 181,000 | 191,000 | 203,000 | 184,000 | 229,000 | 97,000 |
amortization of right-of-use assets | 803,000 | 797,000 | 863,000 | 887,000 | 870,000 | 844,000 | 824,000 | 702,000 | 687,000 | 673,000 | 653,000 | 656,000 | 645,000 | 627,000 | 634,000 | 633,000 | 696,000 | 744,000 | 1,302,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
inventory write off | -338,000 | 0 | 3,976,000 | 0 | 0 | 1,264,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
sublease termination loss | 49,000 | 0 | 0 | 4,765,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accretion of discounts on marketable securities | -1,199,000 | -1,698,000 | -2,137,000 | -3,427,000 | -3,937,000 | -4,528,000 | -4,050,000 | -3,765,000 | -3,498,000 | 9,000 | -87,000 | -418,000 | -552,000 | -323,000 | -465,000 | -505,000 | -176,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stock-based compensation expense | 12,390,000 | 12,979,000 | 14,455,000 | 13,004,000 | 13,083,000 | 13,518,000 | 13,014,000 | 11,309,000 | 10,687,000 | 10,562,000 | 10,034,000 | 1,586,000 | 1,676,000 | 1,270,000 | 1,903,000 | 2,069,000 | 2,322,000 | 1,287,000 | 1,167,000 | 1,480,000 | 586,000 | 425,000 | 541,000 | 933,000 | 916,000 | 667,000 | 519,000 | 717,000 | 1,052,000 | 775,000 | 661,000 | 1,049,000 | 985,000 | 689,000 | 808,000 | 917,000 | 970,000 | ||||||||||||||||||||||||||||||||||||||||||||||||
bad debt expense | 0 | 0 | 10,970,000 | 0 | 0 | 0 | 12,313,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
non-cash interest expense | -2,513,000 | 1,642,000 | 1,691,000 | -1,116,000 | 1,698,000 | -1,121,000 | 1,695,000 | -1,126,000 | 1,690,000 | -1,130,000 | 1,686,000 | -1,134,000 | 1,682,000 | -1,140,000 | 1,680,000 | -938,000 | 414,000 | 413,000 | 403,000 | 388,000 | 1,338,000 | 1,440,000 | 1,398,000 | 1,321,000 | 814,000 | 811,000 | 805,000 | 791,000 | 348,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss on debt extinguishment | 0 | 0 | 82,095,000 | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
changes in operating assets and liabilities: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts and other receivables | 24,000 | -16,788,000 | -9,651,000 | 28,371,000 | -12,647,000 | -16,476,000 | -1,621,000 | 2,333,000 | -1,513,000 | 12,112,000 | 30,336,000 | -16,397,000 | 43,124,000 | -37,306,000 | -5,120,000 | 68,546,000 | -94,462,000 | -21,906,000 | -61,333,000 | 8,362,000 | -30,120,000 | 7,232,000 | 751,000 | -64,000 | -1,240,000 | -1,791,000 | -2,087,000 | -2,197,000 | -203,000 | -541,000 | 91,000 | -71,000 | 27,000 | 655,000 | -123,000 | 948,000 | -426,000 | ||||||||||||||||||||||||||||||||||||||||||||||||
inventories | 2,737,000 | -1,284,000 | -8,325,000 | -9,533,000 | 60,000 | -656,000 | -9,780,000 | -5,526,000 | 3,077,000 | 4,605,000 | 1,753,000 | 23,360,000 | -43,115,000 | 5,059,000 | -17,703,000 | 3,374,000 | 19,154,000 | -17,605,000 | -5,157,000 | -4,656,000 | -4,641,000 | -6,293,000 | -6,767,000 | -1,976,000 | -2,727,000 | -9,060,000 | -8,547,000 | -6,570,000 | -7,340,000 | -4,562,000 | -238,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
prepaid manufacturing | 12,727,000 | 41,750,000 | 83,853,000 | 21,325,000 | -49,892,000 | -73,465,000 | -3,656,000 | -3,219,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
prepaid expenses and other current assets | 3,335,000 | -77,000 | -5,518,000 | -467,000 | 3,647,000 | -1,490,000 | -4,800,000 | -23,000 | -1,478,000 | -1,868,000 | -1,304,000 | 14,375,000 | 34,534,000 | -51,543,000 | -9,231,000 | -12,671,000 | -51,640,000 | -76,000 | -171,000 | 9,580,000 | -9,323,000 | -1,083,000 | -1,000,000 | -1,669,000 | 1,034,000 | -797,000 | 154,000 | -1,498,000 | -721,000 | -580,000 | 394,000 | 11,000 | -199,000 | -1,603,000 | -39,000 | -244,000 | 600,000 | 505,000 | -301,000 | 62,000 | 1,369,000 | -380,000 | 580,000 | -480,000 | 1,400,000 | -2,655,000 | -948,000 | -255,000 | 121,000 | -24,000 | 835,000 | 367,000 | 1,726,000 | -2,277,000 | -738,000 | 263,000 | 395,000 | -273,000 | -155,000 | -281,000 | -262,000 | -15,000 | -216,000 | 422,000 | 223,000 | -133,000 | -107,000 | 360,000 | 262,000 | 67,000 | 844,000 | -111,000 | -653,000 | -78,000 | -1,009,000 | 444,000 | 158,000 | 1,429,000 | -1,427,000 | 330,000 | -19,000 | -721,000 | -113,000 | ||
other assets | -312,000 | -777,000 | -219,000 | 118,000 | -160,000 | 27,000 | 26,000 | 677,000 | 26,000 | 26,000 | 84,000 | -49,000 | 225,000 | 215,000 | -170,000 | -95,000 | -335,000 | -57,000 | 120,000 | 43,000 | 165,000 | -1,710,000 | 1,305,000 | 1,872,000 | -1,142,000 | -1,730,000 | -837,000 | 3,000 | -1,017,000 | 6,000 | 26,000 | -31,000 | -80,000 | -96,000 | 210,000 | -2,000 | 1,157,000 | -6,000 | -2,000 | 0 | -412,000 | 402,000 | 4,000 | ||||||||||||||||||||||||||||||||||||||||||
accounts payable | 1,355,000 | -1,835,000 | -4,668,000 | 1,876,000 | 2,592,000 | 2,071,000 | -2,640,000 | 2,564,000 | -461,000 | -4,247,000 | 4,096,000 | 390,000 | -2,018,000 | -14,619,000 | 16,938,000 | -222,000 | -7,754,000 | 7,504,000 | -295,000 | -2,015,000 | 2,560,000 | -1,898,000 | -2,095,000 | 1,813,000 | 218,000 | -1,607,000 | 4,424,000 | 1,040,000 | 754,000 | 1,274,000 | 349,000 | -416,000 | 1,435,000 | -824,000 | -2,110,000 | 477,000 | -900,000 | 946,000 | 658,000 | 973,000 | -375,000 | -1,395,000 | 2,043,000 | -3,807,000 | 3,172,000 | -42,000 | 154,000 | 220,000 | 36,000 | -474,000 | -439,000 | 588,000 | 423,000 | -1,203,000 | 318,000 | 727,000 | -429,000 | -138,000 | -449,000 | 262,000 | 1,034,000 | -58,000 | -595,000 | 649,000 | -185,000 | 134,000 | 183,000 | -225,000 | -249,000 | -1,385,000 | -1,654,000 | 2,467,000 | -1,454,000 | 1,841,000 | -617,000 | -927,000 | 1,691,000 | 248,000 | -6,000 | 639,000 | 891,000 | -662,000 | -102,000 | ||
lease liabilities | -999,000 | -1,051,000 | -1,101,000 | -1,167,000 | -1,111,000 | -1,084,000 | -1,025,000 | -994,000 | -956,000 | -886,000 | -793,000 | -759,000 | -688,000 | -872,000 | -806,000 | -818,000 | -862,000 | -803,000 | -751,000 | -741,000 | -748,000 | -711,000 | -672,000 | -660,000 | -579,000 | -655,000 | -106,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accrued and other liabilities | -9,984,000 | 10,783,000 | -7,363,000 | 7,065,000 | 3,594,000 | 6,742,000 | -6,368,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net cash from operating activities | 33,829,000 | 23,431,000 | -19,639,000 | 53,011,000 | 19,467,000 | 10,713,000 | -16,679,000 | 13,766,000 | 31,129,000 | 28,046,000 | 27,622,000 | 34,948,000 | 61,560,000 | 16,651,000 | -50,443,000 | 120,497,000 | 66,211,000 | 110,788,000 | 38,032,000 | -15,743,000 | -27,821,000 | -21,821,000 | -26,866,000 | -23,012,000 | -21,977,000 | -36,361,000 | -39,902,000 | -33,630,000 | -33,872,000 | -33,927,000 | -29,872,000 | -17,749,000 | -17,127,000 | -17,392,000 | -25,250,000 | -26,282,000 | -28,208,000 | -25,427,000 | -27,134,000 | -21,846,000 | -23,002,000 | -23,572,000 | -24,139,000 | -16,867,000 | -23,089,000 | -22,606,000 | -11,176,000 | -11,843,000 | -12,255,000 | -15,689,000 | -18,886,000 | -7,592,000 | -12,347,000 | -15,689,000 | -8,181,000 | -5,288,000 | -12,704,000 | -9,629,000 | -19,495,000 | -17,886,000 | -12,189,000 | -13,793,000 | -7,502,000 | -9,291,000 | -8,842,000 | -7,372,000 | -8,047,000 | 3,981,000 | 1,974,000 | -8,725,000 | -14,265,000 | 18,429,000 | -17,104,000 | -18,458,000 | -14,899,000 | -17,681,000 | -1,644,000 | -10,381,000 | -7,534,000 | -8,495,000 | -7,614,000 | 1,307,000 | -8,056,000 | -5,306,000 | -999,000 |
capital expenditures | -832,000 | -1,798,000 | -1,882,000 | -2,517,000 | -1,158,000 | -560,000 | -394,000 | -2,128,000 | -183,000 | -1,137,000 | -357,000 | -1,545,000 | -1,522,000 | -3,706,000 | 649,000 | -4,006,000 | -4,199,000 | 655,000 | -1,336,000 | -772,000 | -25,000 | -970,000 | -1,944,000 | -2,268,000 | -12,972,000 | -7,501,000 | -3,882,000 | -1,349,000 | -1,199,000 | -742,000 | -897,000 | -295,000 | -132,000 | -8,000 | -234,000 | -1,241,000 | -1,600,000 | -2,305,000 | -2,611,000 | -2,724,000 | -2,578,000 | -1,050,000 | -618,000 | 0 | -288,000 | -521,000 | -398,000 | -313,000 | -488,000 | -293,000 | -535,000 | -1,204,000 | -324,000 | -471,000 | -932,000 | -564,000 | -159,000 | -278,000 | -141,000 | -287,000 | -94,000 | -433,000 | 394,000 | 71,000 | -378,000 | -505,000 | 435,000 | 230,000 | 444,000 | -1,374,000 | -3,398,000 | 0 | 0 | 0 | -711,000 | -647,000 | 0 | 0 | -39,000 | -110,000 | -89,000 | -282,000 | -81,000 | -209,000 | -1,190,000 |
free cash flows | 32,997,000 | 21,633,000 | -21,521,000 | 50,494,000 | 18,309,000 | 10,153,000 | -17,073,000 | 11,638,000 | 30,946,000 | 26,909,000 | 27,265,000 | 33,403,000 | 60,038,000 | 12,945,000 | -49,794,000 | 116,491,000 | 62,012,000 | 111,443,000 | 36,696,000 | -16,515,000 | -27,846,000 | -22,791,000 | -28,810,000 | -25,280,000 | -34,949,000 | -43,862,000 | -43,784,000 | -34,979,000 | -35,071,000 | -34,669,000 | -30,769,000 | -18,044,000 | -17,259,000 | -17,400,000 | -25,484,000 | -27,523,000 | -29,808,000 | -27,732,000 | -29,745,000 | -24,570,000 | -25,580,000 | -24,622,000 | -24,757,000 | -16,867,000 | -23,377,000 | -23,127,000 | -11,574,000 | -12,156,000 | -12,743,000 | -15,982,000 | -19,421,000 | -8,796,000 | -12,671,000 | -16,160,000 | -9,113,000 | -5,852,000 | -12,863,000 | -9,907,000 | -19,636,000 | -18,173,000 | -12,283,000 | -14,226,000 | -7,108,000 | -9,220,000 | -9,220,000 | -7,877,000 | -7,612,000 | 4,211,000 | 2,418,000 | -10,099,000 | -17,663,000 | 18,429,000 | -17,104,000 | -18,458,000 | -15,610,000 | -18,328,000 | -1,644,000 | -10,381,000 | -7,573,000 | -8,605,000 | -7,703,000 | 1,025,000 | -8,137,000 | -5,515,000 | -2,189,000 |
investing activities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchases of marketable securities | -139,862,000 | -18,096,000 | -93,697,000 | -33,016,000 | -164,926,000 | -175,436,000 | -150,685,000 | -152,881,000 | -224,509,000 | -74,230,000 | -185,301,000 | -117,630,000 | -201,016,000 | -63,285,000 | -250,375,000 | -1,000 | 1,000 | -92,912,000 | -72,016,000 | -29,804,000 | -68,800,000 | -85,197,000 | -17,985,000 | -34,043,000 | -72,807,000 | -79,136,000 | -29,205,000 | -25,996,000 | -987,000 | -45,718,000 | -141,103,000 | -34,988,000 | -99,639,000 | -48,393,000 | -44,652,000 | -4,727,000 | -23,919,000 | -37,051,000 | -61,057,000 | -81,018,000 | -109,264,000 | 0 | -18,654,000 | 0 | -7,556,000 | -23,432,000 | -13,819,000 | -143,471,000 | -19,046,000 | -16,073,000 | -13,454,000 | -36,515,000 | -55,234,000 | -81,564,000 | -32,836,000 | -73,198,000 | -18,498,000 | -18,505,000 | -1,004,000 | -49,941,000 | -2,537,000 | 0 | -2,000 | -2,016,000 | -12,271,000 | -12,673,000 | -9,662,000 | -7,494,000 | -5,926,000 | -38,753,000 | -975,000 | -24,414,000 | -16,090,000 | -46,215,000 | -11,974,000 | 0 | -7,653,000 | -44,811,000 | -3,491,000 | -20,021,000 | -15,691,000 | ||||
proceeds from maturities and redemption of marketable securities | 168,422,000 | 114,340,000 | 104,535,000 | 150,807,000 | 147,448,000 | 154,265,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchases of property and equipment | -1,237,000 | -1,452,000 | -3,928,000 | -3,478,000 | -1,346,000 | -779,000 | -749,000 | -1,723,000 | -347,000 | -751,000 | -1,283,000 | -1,587,000 | -1,281,000 | -2,913,000 | -1,358,000 | -3,036,000 | -3,629,000 | -1,065,000 | -1,747,000 | -769,000 | -265,000 | -686,000 | -2,352,000 | -1,831,000 | -9,187,000 | -7,501,000 | -3,882,000 | -1,349,000 | -1,199,000 | -742,000 | -897,000 | -295,000 | -132,000 | -8,000 | -234,000 | -1,241,000 | -1,600,000 | -2,305,000 | -2,611,000 | -2,724,000 | -2,578,000 | -1,050,000 | -618,000 | -313,000 | -488,000 | -293,000 | -535,000 | -1,204,000 | -324,000 | -471,000 | -932,000 | -564,000 | -159,000 | -278,000 | -141,000 | -287,000 | -94,000 | -433,000 | 394,000 | 71,000 | -378,000 | -505,000 | 435,000 | 230,000 | 444,000 | -1,374,000 | -3,398,000 | -711,000 | -647,000 | -39,000 | -110,000 | -89,000 | -282,000 | -81,000 | -209,000 | -1,190,000 | |||||||||
net cash from investing activities | 27,323,000 | 94,792,000 | 6,910,000 | 23,366,000 | -15,465,000 | -28,767,000 | 2,831,000 | -20,242,000 | -106,074,000 | 24,722,000 | -52,334,000 | -32,967,000 | -119,047,000 | 52,502,000 | -216,483,000 | 54,938,000 | 45,672,000 | -63,752,000 | -22,633,000 | 14,342,000 | -2,054,000 | -49,383,000 | 10,563,000 | 24,851,000 | -40,219,000 | -42,027,000 | 14,613,000 | 44,412,000 | 43,564,000 | 27,175,000 | -59,685,000 | 6,057,000 | -82,348,000 | -25,401,000 | -7,011,000 | 28,122,000 | 25,981,000 | 11,394,000 | 20,752,000 | -36,552,000 | -63,507,000 | 24,785,000 | -10,522,000 | 37,111,000 | 25,862,000 | 12,892,000 | 14,732,000 | -102,568,000 | 6,660,000 | 8,205,000 | 36,351,000 | 4,583,000 | 1,442,000 | -39,375,000 | -6,343,000 | -48,722,000 | 17,000,000 | -28,790,000 | 394,000 | 1,700,000 | 7,195,000 | 7,745,000 | 3,235,000 | 1,634,000 | 7,125,000 | 7,728,000 | 13,629,000 | -20,813,000 | 21,592,000 | -18,028,000 | 13,652,000 | -29,248,000 | 7,264,000 | -13,990,000 | 15,594,000 | -35,104,000 | 21,282,000 | -7,658,000 | 2,773,000 | -49,846,000 | -1,190,000 | ||||
financing activities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of convertible notes | 0 | 0 | 39,708,000 | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
payment for debt issuance costs | 0 | -562,000 | -3,938,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
payments for debt extinguishment | 0 | 0 | -80,938,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from unwind of capped call options | 0 | 0 | 46,554,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
payments for repurchase of common stock | -572,000 | -71,170,000 | -29,465,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from exercise of stock options | 95,000 | 235,000 | 6,503,000 | 1,871,000 | 419,000 | 1,635,000 | 446,000 | 272,000 | 1,071,000 | 0 | 65,000 | 28,000 | 40,000 | 3,000 | 9,000 | 0 | 0 | 0 | 0 | 5,000 | 0 | 0 | 22,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from employee stock purchase plan | 664,000 | 0 | 835,000 | 0 | 856,000 | 0 | 904,000 | 0 | 758,000 | 0 | 777,000 | 1,000 | 720,000 | 0 | 710,000 | 0 | 458,000 | 0 | 383,000 | 0 | 361,000 | 0 | 311,000 | 0 | 158,000 | 0 | 407,000 | 0 | 339,000 | 0 | 255,000 | 1,000 | 137,000 | 0 | 155,000 | -1,000 | 355,000 | 0 | 261,000 | 0 | 188,000 | 0 | 103,000 | 0 | 60,000 | 1,000 | 69,000 | 0 | 77,000 | 0 | 147,000 | 0 | 179,000 | 0 | 128,000 | 0 | 92,000 | 0 | 40,000 | 0 | 30,000 | 0 | 42,000 | 0 | 35,000 | 0 | 37,000 | 0 | 68,000 | 0 | 136,000 | 0 | 78,000 | 0 | 71,000 | 0 | 57,000 | 0 | 57,000 | -1,000 | 49,000 | 0 | 66,000 | ||
payments for taxes related to net share settlement of restricted and performance stock units | -248,000 | -421,000 | -11,141,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net cash from financing activities | -61,000 | -71,918,000 | -31,882,000 | -98,875,000 | 2,476,000 | -1,415,000 | -4,203,000 | 1,776,000 | 2,994,000 | -294,000 | -3,090,000 | 153,000 | 8,057,000 | 1,028,000 | 10,287,000 | 14,816,000 | 5,322,000 | 3,335,000 | 32,303,000 | 66,000 | 1,412,000 | 93,482,000 | 14,539,000 | 0 | 65,744,000 | 345,000 | 88,262,000 | 6,000 | 359,000 | -123,000 | 98,829,000 | 18,078,000 | 81,712,000 | 58,665,000 | 29,387,000 | -216,000 | 387,000 | 24,000 | 336,000 | 300,000 | 153,006,000 | 20,514,000 | 139,000 | 9,758,000 | 60,000 | 14,000 | 69,000 | 125,290,000 | 76,000 | 20,000 | 15,000 | -14,178,000 | 930,000 | 70,037,000 | 2,253,000 | 67,054,000 | 4,787,000 | 18,660,000 | 939,000 | 43,364,000 | 2,122,000 | 41,229,000 | 916,000 | 19,708,000 | 2,310,000 | 4,000 | 37,000 | 0 | -749,000 | 0 | 2,141,000 | 2,000,000 | 3,578,000 | 30,000,000 | 74,000 | 45,070,000 | 219,000 | 17,554,000 | 57,000 | 33,157,000 | 384,000 | 66,000 | 98,000 | 228,000 | -256,000 |
effect of exchange rate changes on cash and cash equivalents, and restricted cash | 55,000 | 1,100,000 | 458,000 | -960,000 | 363,000 | -64,000 | -201,000 | 479,000 | -305,000 | -1,000 | 151,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net increase in cash and cash equivalents, and restricted cash | 61,146,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents, and restricted cash at beginning of period | 0 | 0 | 96,154,000 | 0 | 0 | 150,556,000 | 0 | 0 | 202,211,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents, and restricted cash at end of period | 61,146,000 | 47,405,000 | 52,001,000 | 6,841,000 | -19,533,000 | 132,304,000 | -72,256,000 | 52,473,000 | 174,560,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
supplemental disclosure of cash flow information | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash paid during the period for income taxes | 455,000 | 1,737,000 | 413,000 | 1,614,000 | 2,014,000 | 949,000 | 703,000 | 678,000 | 32,000 | 279,000 | 422,000 | 87,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash paid during the period for interest | 0 | 503,000 | 1,518,000 | 0 | 0 | 0 | 4,912,000 | -2,243,000 | 4,296,000 | 4,392,000 | 4,345,000 | 3,412,000 | 3,415,000 | 3,360,000 | 1,940,000 | 1,930,000 | 1,900,000 | 813,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
non-cash investing and financing activities: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchases of property and equipment, not yet paid | 405,000 | -346,000 | 2,046,000 | 961,000 | 188,000 | 219,000 | 355,000 | -405,000 | 164,000 | -386,000 | 926,000 | 42,000 | -241,000 | -793,000 | 2,007,000 | -970,000 | -570,000 | 1,720,000 | 411,000 | -3,000 | 240,000 | -284,000 | 408,000 | -437,000 | -3,785,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
right-of-use assets obtained in exchange of operating lease liabilities | 431,000 | 623,000 | 278,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net loss | -96,099,000 | -8,721,000 | -36,756,000 | -33,459,000 | -42,713,000 | -39,672,000 | -39,969,000 | -40,528,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
adjustments to reconcile net loss to net cash from operating activities: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net decrease in cash and cash equivalents, and restricted cash | -44,153,000 | -23,458,000 | -18,252,000 | -27,651,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
inventory write-off | 19,803,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
amortization of premiums (accretion of discounts) on marketable securities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
change in fair value of warrant liability | 0 | 0 | 0 | -1,801,000 | -19,222,000 | 45,121,000 | -2,097,000 | 25,552,000 | 76,000 | -21,245,000 | 25,655,000 | -8,610,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
gain on sale of assets | 0 | 0 | 0 | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cepi accrual | 0 | 368,000 | 0 | -21,478,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred revenue | -87,395,000 | -104,603,000 | -121,205,000 | -36,661,000 | -8,724,000 | 229,031,000 | 13,005,000 | 78,340,000 | 16,500,000 | -250,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from maturities and redemptions of marketable securities | 86,250,000 | 83,250,000 | 117,700,000 | 35,250,000 | 57,975,000 | 48,300,000 | 30,225,000 | 51,130,000 | 30,915,000 | 43,250,000 | 36,500,000 | 37,900,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from sale of assets, net of transaction costs | 0 | 0 | 3,992,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from warrants exercises | 0 | 8,455,000 | 13,556,000 | 882,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from exercise of stock options and/or release of restricted stock awards | 2,021,000 | 2,722,000 | 1,378,000 | 239,000 | 1,122,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
payments for taxes related to net share settlement of rsus | -245,000 | -486,000 | -1,672,000 | -4,106,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents, and restricted cash at beginning of year | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents, and restricted cash at end of year | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash paid during the year for income taxes | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash paid during the year for interest | 0 | 287,000 | 249,000 | 184,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
reclassification of contract asset from other current assets to other assets | 0 | 0 | 0 | 71,307,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
reclassification of cepi accrual to cepi accrual long-term | 0 | 0 | 0 | -60,337,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
advance payments forgiven per cepi-bio e assignment agreement | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
right-of-use assets obtained in exchange for operating lease liabilities | 1,522,000 | 4,297,000 | 0 | 34,807,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from sale of assets | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
payments for taxes related to net share settlement of restricted stock units | -251,000 | -1,834,000 | -6,742,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuances of common stock | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchases of capped call options | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
repayment of long-term debt | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
amortization of right-of-use assets and loss on disposal of property and equipment | 755,000 | 693,000 | 642,000 | 600,000 | 901,000 | 743,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accrued liabilities and other liabilities | 8,943,000 | 7,413,000 | -5,001,000 | 3,574,000 | 16,972,000 | -39,589,000 | 62,330,000 | 10,604,000 | -2,847,000 | 10,023,000 | 373,000 | -3,728,000 | -3,777,000 | 4,304,000 | -7,878,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from maturities of marketable securities | 117,782,000 | 99,703,000 | 134,250,000 | 41,775,000 | 44,610,000 | 54,700,000 | 71,757,000 | 47,250,000 | 73,635,000 | 91,815,000 | 41,340,000 | 17,423,000 | 23,000,000 | 37,875,000 | 34,090,000 | 51,500,000 | 50,750,000 | 84,420,000 | 47,190,000 | 48,335,000 | 25,835,000 | 8,750,000 | 37,571,000 | 33,706,000 | 36,845,000 | 28,949,000 | 41,216,000 | 26,194,000 | 24,571,000 | 50,340,000 | 42,302,000 | 57,000,000 | 42,660,000 | 27,425,000 | 25,054,000 | 18,308,000 | 16,222,000 | 18,145,000 | 19,000,000 | 0 | 6,500,000 | 9,250,000 | 13,750,000 | 12,501,000 | 15,000,000 | 15,150,000 | 16,750,000 | 18,100,000 | 21,000,000 | ||||||||||||||||||||||||||||||||||||
adjustments to reconcile net income to net cash provided by (used in) operating activities: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss on disposal of property and equipment and from lease termination | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
realized gain on available-for-sale securities | -1,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stock compensation expense | 8,727,000 | 8,613,000 | 7,929,000 | 7,646,000 | 6,162,000 | 5,376,000 | 5,024,000 | 4,723,000 | 3,516,000 | 4,102,000 | 4,088,000 | 1,778,000 | 5,189,000 | 4,748,000 | 9,349,000 | 6,170,000 | 6,343,000 | 6,046,000 | 6,290,000 | 4,799,000 | 4,073,000 | 3,660,000 | 3,363,000 | 3,821,000 | 4,096,000 | 3,662,000 | 3,124,000 | 3,244,000 | 2,814,000 | 2,630,000 | 1,918,000 | 1,954,000 | 1,493,000 | 2,845,000 | 3,736,000 | 4,266,000 | |||||||||||||||||||||||||||||||||||||||||||||||||
cost of sales - amortization of intangible assets | 0 | 0 | 202,000 | 2,298,000 | 2,323,000 | 2,324,000 | 2,297,000 | 2,273,000 | 2,324,000 | 3,823,000 | 2,298,000 | 2,417,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
tenant improvements provided by the landlord | 229,000 | 0 | 0 | 908,000 | 360,000 | 3,411,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
acquisition of technology licenses | 0 | 0 | 0 | -7,000,000 | 0 | 0 | 0 | -7,000,000 | 0 | -1,500,000 | 0 | -9,500,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from sales of marketable securities | 10,008,000 | 0 | -1,000 | 0 | 4,047,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from exercise of stock options and release of restricted stock awards | 152,000 | 7,337,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
amortization of premium (accretion of discounts) on marketable securities | 73,000 | 148,000 | 221,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term deferred revenue | -38,981,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of common stock | 0 | 0 | 28,156,000 | 840,000 | 93,468,000 | 14,229,000 | 51,999,000 | 326,000 | 13,623,000 | 80,987,000 | 58,665,000 | 29,535,000 | 163,686,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from warrants exercised | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
effect of exchange rate changes on cash, cash equivalents and restricted cash | -1,098,000 | -523,000 | -134,000 | -418,000 | -467,000 | 185,000 | -731,000 | 731,000 | 675,000 | 313,000 | -225,000 | 345,000 | -485,000 | 148,000 | -192,000 | -155,000 | -67,000 | -477,000 | 217,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net increase in cash, cash equivalents and restricted cash | -50,528,000 | 69,658,000 | -256,773,000 | 189,833,000 | 116,738,000 | 50,556,000 | 46,971,000 | 22,591,000 | -1,989,000 | 2,184,000 | 3,063,000 | -77,895,000 | 62,781,000 | 10,633,000 | 9,984,000 | -7,352,000 | 9,489,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash, cash equivalents and restricted cash at beginning of period | 0 | 0 | 436,408,000 | 0 | 0 | 32,310,000 | 0 | 0 | 40,100,000 | 0 | 0 | 49,967,000 | 0 | 0 | 27,213,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash, cash equivalents and restricted cash at end of period | -50,528,000 | 69,658,000 | 179,635,000 | 116,738,000 | 50,556,000 | 79,281,000 | -27,788,000 | 22,591,000 | 38,111,000 | 3,063,000 | -77,895,000 | 112,748,000 | 9,984,000 | -7,352,000 | 36,702,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
right-of-use assets obtained in exchange of lease liabilities | 708,000 | 594,000 | 1,173,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
remeasurement of operating lease right-of-use assets for lease modification | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(accretion of discounts) amortization of premium on marketable securities | -317,000 | -181,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
gain on disposal of property and equipment and from lease termination | 0 | 0 | -76,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from long-term debt | 0 | 0 | 0 | 74,250,000 | 0 | 0 | 0 | 99,000,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuances of preferred stock | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from exercise of stock options and restricted stock awards | 1,260,000 | 3,982,000 | 211,000 | 32,000 | 24,000 | 75,000 | 294,000 | 128,000 | 99,000 | 10,000 | 36,000 | 0 | 82,000 | 0 | 20,000 | 10,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash, cash equivalents and restricted cash at beginning of year | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash, cash equivalents and restricted cash at end of year | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds allocated to warrant liability at issuance | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
interest expense | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from exercise of warrants | 3,377,000 | 6,000 | -6,000 | 202,000 | 26,000 | 300,000 | 151,000 | 1,054,000 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds (tax withholding) from exercise of stock options and restricted stock awards | 387,000 | 0 | 1,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(gain) loss on disposal of property and equipment and from lease termination | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
non-cash acquisition of technology license | 0 | 0 | 0 | 12,773,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of preferred stock | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net decrease in cash, cash equivalents and restricted cash | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(tax withholding) from exercise of stock options and restricted stock awards | -1,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss on disposal of property and equipment | 0 | 1,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accretion of discounts and amortization of premiums on marketable securities | -89,000 | -69,000 | -25,000 | -10,000 | 23,000 | 32,000 | 48,000 | 75,000 | 162,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
reversal of deferred rent upon lease amendment | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accrued liabilities and other long-term liabilities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
release of accrual for litigation settlement and insurance recovery | 925,000 | 0 | 0 | 4,050,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
revaluation of warrant liability | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
disposal of fully depreciated property and equipment | 8,437,000 | 130,000 | 851,000 | 0 | 157,000 | 5,000 | 37,000 | 1,194,000 | 2,000 | 4,000 | 1,154,000 | 1,265,000 | 167,000 | 0 | 4,000 | 166,000 | 11,000 | 390,000 | 274,000 | 78,000 | 0 | 7,000 | 1,000 | 140,000 | 10,000 | 14,000 | 5,000 | 836,000 | 308,000 | 52,000 | 63,000 | 792,000 | 212,000 | 2,000 | 6,000 | 18,000 | 140,000 | ||||||||||||||||||||||||||||||||||||||||||||||||
tax withholding from exercise of stock options and restricted stock awards | -18,000 | -123,000 | -426,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
write-off of assets in progress | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash-settled portion of stock compensation expense | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accrued liabilities and other long term liabilities | 6,433,000 | 4,834,000 | 1,054,000 | 276,000 | 4,472,000 | 390,000 | -301,000 | -1,363,000 | -11,473,000 | 2,874,000 | 656,000 | -3,816,000 | 8,653,000 | 2,998,000 | -277,000 | -2,357,000 | 476,000 | 1,117,000 | 4,888,000 | -1,671,000 | 198,000 | 269,000 | -853,000 | -1,905,000 | 905,000 | 1,831,000 | 1,024,000 | -1,844,000 | 830,000 | 191,000 | -403,000 | -2,785,000 | -6,566,000 | 2,886,000 | 3,997,000 | 3,064,000 | 674,000 | -142,000 | 83,000 | ||||||||||||||||||||||||||||||||||||||||||||||
deferred revenues | 0 | 0 | -1,759,000 | -895,000 | -7,892,000 | -818,000 | -929,000 | -472,000 | 6,266,000 | -1,795,000 | -2,040,000 | 3,036,000 | -1,579,000 | -1,289,000 | -1,014,000 | -888,000 | 3,121,000 | 776,000 | -1,479,000 | -946,000 | 4,584,000 | -357,000 | -358,000 | -357,000 | -357,000 | -10,357,000 | -1,312,000 | -691,000 | -766,000 | -903,000 | -13,227,000 | -16,948,000 | 5,673,000 | 2,505,000 | -176,000 | -576,000 | 33,438,000 | 233,000 | -200,000 | -30,000 | -649,000 | 10,598,000 | -48,000 | 48,000 | -7,000,000 | ||||||||||||||||||||||||||||||||||||||||
(tax withholding) proceeds from exercise of stock options and restricted stock awards | 6,000 | 0 | -303,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accrual for litigation settlement and insurance recovery | 925,000 | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
return of unused development funding to astrazeneca ab | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
milestone payment from astrazeneca ab | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
gain on disposal of property and equipment | -8,000 | -3,000 | -21,000 | 0 | -4,000 | -20,000 | 14,000 | 0 | 0 | 0 | -50,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
common stock issuance costs - cash not paid as of period end | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(gain) loss on disposal of property and equipment | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accretion of debt discount related to debt financing | 0 | -15,000 | -49,000 | -51,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
amortization of intangible assets | 0 | 0 | 54,000 | 245,000 | 245,000 | 245,000 | 245,000 | 245,000 | 245,000 | 245,000 | 245,000 | 245,000 | 245,000 | 245,000 | 245,000 | 245,000 | 249,000 | 252,000 | 251,000 | 252,000 | 251,000 | 251,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss on extinguishment of debt | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
restricted cash and other assets | -907,000 | -4,000 | 16,000 | -79,000 | -36,000 | 0 | 852,000 | 4,000 | -845,000 | 266,000 | 10,000 | 152,000 | 1,000 | 13,000 | -42,000 | -5,000 | 14,000 | -83,000 | -126,000 | 14,000 | -117,000 | -61,000 | 2,016,000 | -26,000 | -1,004,000 | -1,024,000 | -10,000 | -16,000 | 17,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
payment of debt | 2,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds (withholding) from exercise of stock options and restricted stock awards | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
effect of exchange rate changes on cash and cash equivalents | 102,000 | 184,000 | 331,000 | 57,000 | -356,000 | 74,000 | -62,000 | 92,000 | -121,000 | 48,000 | 46,000 | -276,000 | -147,000 | -209,000 | -18,000 | 3,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net increase in cash and cash equivalents | 1,268,000 | -58,219,000 | -34,798,000 | 29,855,000 | 2,624,000 | -9,718,000 | 3,628,000 | 10,931,000 | -5,394,000 | -7,431,000 | 17,417,000 | 11,985,000 | 976,000 | 839,000 | -5,183,000 | 5,485,000 | 7,748,000 | -988,000 | 1,565,000 | -349,000 | 8,139,000 | -6,476,000 | -1,175,000 | -1,797,000 | 8,117,000 | -10,443,000 | 14,052,000 | -6,285,000 | -5,189,000 | -54,924,000 | -2,445,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents at beginning of year | 0 | 0 | 0 | 7,599,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents at end of year | 10,931,000 | -5,394,000 | -7,431,000 | 25,016,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net change in unrealized gain on marketable securities | -52,000 | 14,000 | -16,000 | -29,000 | -15,000 | -61,000 | -41,000 | 109,000 | 7,000 | 5,000 | -9,000 | 8,000 | -37,000 | -1,000 | 1,000 | 69,000 | -53,000 | 18,000 | -33,000 | -8,000 | 16,000 | 59,000 | -7,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash-settled portion of stock-based compensation expense | 0 | 274,000 | 328,000 | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net decrease in cash and cash equivalents | -2,817,000 | -14,071,000 | -5,954,000 | -9,880,000 | 14,777,000 | -12,188,000 | -1,482,000 | -844,000 | -1,027,000 | -6,640,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents at beginning of period | 0 | 0 | 24,289,000 | 0 | 0 | 44,812,000 | 0 | 0 | 49,511,000 | 0 | 0 | 23,122,000 | 0 | 0 | 31,941,000 | 0 | 0 | 22,453,000 | 0 | 0 | 36,720,000 | 0 | 0 | 28,103,000 | 0 | 0 | 14,293,000 | 0 | 0 | 14,154,000 | 0 | 0 | 8,725,000 | 0 | 0 | 16,590,000 | |||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents at end of period | -17,579,000 | 16,203,000 | 21,472,000 | -1,766,000 | -14,071,000 | 38,858,000 | 66,545,000 | 21,773,000 | 14,713,000 | 2,624,000 | -9,718,000 | 26,750,000 | -9,880,000 | 14,777,000 | 19,753,000 | -8,407,000 | 6,508,000 | 20,971,000 | -844,000 | -1,027,000 | 30,080,000 | 976,000 | 839,000 | 22,920,000 | 7,748,000 | -988,000 | 15,858,000 | 8,139,000 | -6,476,000 | 12,979,000 | 5,861,000 | -6,752,000 | 16,842,000 | 14,052,000 | -6,285,000 | 11,401,000 | |||||||||||||||||||||||||||||||||||||||||||||||||
unoccupied facility expense | 131,000 | 178,000 | 77,000 | 8,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(withholding) proceeds from exercise of stock options and restricted stock awards | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
return of unused development funding to astrazeneca ab “astrazeneca” | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
milestone payment from astrazeneca | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accretion of end of term payment related to debt financing | 50,000 | 57,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts receivable | 230,000 | -231,000 | -506,000 | 252,000 | -182,000 | 0 | 565,000 | 438,000 | -103,000 | 532,000 | -134,000 | -478,000 | -542,000 | 2,680,000 | -2,401,000 | 91,000 | 8,152,000 | -8,744,000 | 356,000 | -12,000 | -126,000 | 254,000 | 94,000 | -197,000 | -257,000 | 289,000 | 335,000 | 1,459,000 | 3,429,000 | -191,000 | 1,841,000 | -1,917,000 | 1,094,000 | -6,660,000 | 528,000 | 116,000 | 936,000 | -269,000 | -1,175,000 | 197,000 | 271,000 | -317,000 | 8,213,000 | -5,826,000 | 1,028,000 | ||||||||||||||||||||||||||||||||||||||||
accretion of discounts and amortization of premiums of marketable securities | 171,000 | 167,000 | 214,000 | 236,000 | 264,000 | 231,000 | 162,000 | 250,000 | 280,000 | 328,000 | 332,000 | 334,000 | 304,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from long-term debt payable to hercules | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss on lease | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
interest associated with long-term note payable to symphony dynamo holdings llc | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
payment of notes payable to holdings | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchases of property and equipment, net of proceeds from asset disposals | -288,000 | -521,000 | -398,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
payment of issuance costs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuances of common stock and warrants, net of issuance costs | -142,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
fair value adjustment of the warrant and contingent liabilities to holdings, including the impact of the anti-dilution provision associated with the common stock and warrants issued to symphony capital partners, l.p. and symphony strategic partners, llc | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuances of warrants | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
interest associated with long-term note payable to holdings | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
payments and proceeds from issuances of common stock and warrants, net of issuance costs | -1,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
effect of exchange rate on cash and cash equivalents | 125,000 | 33,000 | -63,000 | 136,000 | 95,000 | -196,000 | 83,000 | -175,000 | -155,000 | 38,000 | 74,000 | -6,000 | 104,000 | 327,000 | -448,000 | -132,000 | 313,000 | 462,000 | -408,000 | -130,000 | -602,000 | 9,000 | 60,000 | 35,000 | 73,000 | 10,000 | -2,000 | 62,000 | 22,000 | -1,000 | 0 | 0 | -4,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
shares issued to aspire capital in conjunction with purchase agreement | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
shares issued in conjunction with the symphony dynamo, inc. (“sdi”) transaction | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
warrants issued in conjunction with the sdi transaction | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
gain on disposal of assets | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
non-cash interest associated with the note payable to holdings | 547,000 | 548,000 | 547,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
fair value adjustment of the warrant and contingent liabilities to holdings | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from offering of common stock, net of issuance costs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(gain)/loss on disposal of assets | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of common stock, net of issuance costs | 4,591,000 | 18,653,000 | 834,000 | 43,275,000 | 2,064,000 | 42,108,000 | -48,000 | -33,000 | -79,000 | 75,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net income attributable to dynavax | -15,122,000 | -4,998,000 | -28,004,000 | -9,184,000 | -30,270,000 | -9,506,000 | 4,110,000 | 5,101,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
consideration paid in excess of carrying value of the noncontrolling interest in sdi | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
amount attributed to noncontrolling interest in sdi | -1,041,000 | -1,200,000 | -983,000 | -1,009,000 | -939,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
non-cash interest associated with long-term note payable to holdings | 468,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
fair value adjustment of the warrant and contingent liabilities to holdings, including the impact of the anti-dilution provision associated with the common stock and warrants issued to symphony | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
interest associated with deerfield financing agreement | 0 | 1,323,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
change in investments held by sdi | 1,629,000 | 1,075,000 | 1,016,000 | 1,321,000 | 1,576,000 | 1,344,000 | 1,446,000 | 2,156,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash acquired from the purchase of noncontrolling interest in sdi | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
note payable issued to holdings from purchase option exercised under the sdi collaboration | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
shares issued in conjunction with the sdi transaction | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liability from program option exercised under the sdi collaboration | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
modification of warrants previously issued to deerfield | 9,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
fair value adjustments to the common stock, warrant and contingent liability issued to holdings | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accretion and amortization of marketable securities | 278,000 | 263,000 | 354,000 | 242,000 | 83,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from the sale of property and equipment | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from exercise of stock options and delivery of restricted stock units | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
disposal of fully depreciated assets | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net change in unrealized losses on marketable securities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
non-cash interest associated with long-term note payable to symphony dynamo holdings llc | 467,000 | 468,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
fair value adjustment of the warrant and contingent liabilities to symphony dynamo holdings llc | 20,000 | -3,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net cash provided (used) by investing activities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
fair value adjustment of the warrant and contingent liabilities to holdings, including the impact of the anti-dilution provision associate with the common stock and warrants issued to symphony | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loan forgiveness | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from notes payable issued to deerfield | 0 | 0 | 0 | 2,000,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
repayment of notes payable issued to deerfield | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
non-cash interest associated with deerfield financing agreement | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
non-cash interest associated with note payable to holdings | 400,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
fair value of the common stock, warrants and contingent liability issued to holdings | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net cash (used in ) provided by investing activities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
fair value of the common stock, warrant, and contingent liability to holdings | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
interest associated with note payable to holdings | 399,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
change in the fair value of the warrant and contingent consideration to holdings | -183,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of common stock under equity distribution agreement, net of issuance costs | 919,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accretion and amortization on marketable securities | 0 | 10,000 | 24,000 | -30,000 | -100,000 | -88,000 | -202,000 | -331,000 | -277,000 | -339,000 | -551,000 | -688,000 | -448,000 | -17,000 | 60,000 | 109,000 | 210,000 | 322,000 | 318,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
inventory | 263,000 | -15,000 | -2,000 | 11,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accrued liabilities | -5,161,000 | 1,152,000 | 114,000 | -2,234,000 | 900,000 | 1,136,000 | -152,000 | -954,000 | 3,812,000 | -319,000 | 1,486,000 | 868,000 | -639,000 | 309,000 | -131,000 | 1,650,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from purchase of noncontrolling interest by preferred shareholders in sdi, net of fees | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
non-cash activities: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
note payable to holdings from purchase option exercised under the sdi collaboration | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
warrants issued in conjunction with the deerfield financing agreement | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss on the disposal of assets | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
acquired in-process research and development | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
realized loss on investments | 23,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash paid for acquisition, net of cash acquired | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from purchase of noncontrolling interest by shareholders in sdi, net of fees | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss on disposal of assets | 23,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
interest expense associated with deerfield financing agreement | 6,885,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from the purchase of noncontrolling interest in sdi, net of fees | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
supplemental disclosure of non-cash flow information | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
warrants issued in conjunction with deerfield financing agreement | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
amount attributed to noncontrolling interest in symphony dynamo, inc. | -1,489,000 | -1,566,000 | -2,001,000 | -1,621,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
realized gain on investments | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
interest accrued on notes receivable from stockholders | 0 | -4,000 | -5,000 | -7,000 | -9,000 | -9,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchases of investments held by sdi | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
exercise of stock options | 1,029,000 | 162,000 | 13,000 | 0 | -194,000 | 200,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
repayment of notes receivable from stockholders | 8,000 | 335,000 | 60,000 | 32,000 | 221,000 | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liability from program option exercised under the sdi transaction | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
repurchase of common stock for exercise of stock options | 0 | 0 | 0 | -200,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
realized loss on sale of marketable securities | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
increase in interest payable | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchases disposal of property and equipment | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from deerfield financing agreement | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
issuance cost associated with common stock offering | 0 | 0 | -19,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
supplemental disclosure of non-cash investing and financing activities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
warrants issued in conjunction with sdi transaction | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
change in investments held by symphony dynamo, inc. | -26,489,000 | 4,754,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(purchases) disposal of property and equipment | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from purchase of noncontrolling interest by preferred shareholders in symphony dynamo, inc., net of fees | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
warrants issued in conjunction with the symphony dynamo, inc. transaction | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss attributed to noncontrolling interest in symphony dynamo, inc. | -2,016,000 | -3,271,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
maturities and sales of marketable securities | 25,699,000 | 13,250,000 | 18,440,000 | 19,019,000 | 23,286,000 | 9,817,000 | 24,862,000 | 12,645,000 | 18,545,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchases of investments held by symphony dynamo, inc. | 4,364,000 | 1,317,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from purchase of noncontrolling interest by shareholders in symphony dynamo, inc., net of fees | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
restricted cash | 0 | -331,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
change in unrealized gain on marketable securities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
lease incentive | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
conversion of preferred stock upon initial public offering | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
conversion of ordinary shares in dynavax asia upon initial public offering | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
interest accrued on notes receivable | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
change in unrealized loss on marketable securities | 79,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
change in cumulative translation adjustment | 22,000 | -1,000 | 0 | 0 | -4,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
disposal (purchases) of property and equipment | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net increase increase in cash and cash equivalents | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
adjustments to reconcile net income (income) to net cash from operating activities: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
amortization of stock-based compensation expense | 666,000 | 439,000 | 308,000 | 336,000 | 317,000 | 793,000 | 728,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net change in unrealized loss on marketable securities | 29,000 | -48,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
realized loss on investment | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of ordinary shares in dynavax asia, net of issuance costs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
repurchase of common stock | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
repurchase of common stock for notes receivable | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deemed dividend upon issuance of ordinary shares of dynavax asia | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
conversion of ordinary shares in dynavax asia upon initial public offering. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net unrealized loss on marketable securities | 41,000 | -59,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of preferred stock, net of issuance costs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
repayments of equipment financing | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accretion and amortization on investments | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchase of marketable securities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
maturities and sale of marketable securities | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents at beginning of the period | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents at end of the period | -2,445,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
interest paid | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net unrealized gain on marketable securities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
issuance of common stock for notes receivable | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
marketable securities, at cost | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
unrealized gains |
