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Deciphera Pharmaceuticals, Inc
(NASDAQ:DCPH) 

DCPH stock logo

Deciphera Pharmaceuticals, Inc., a biopharmaceutical company, develops drugs to enhance the lives of cancer patients by addressing key mechanisms of drug resistance that limit the rate and durability of response to existing cancer therapies. Its lead drug candidate is QINLOCK used for the treatment ...

Full Time Employees: 255
Sector: Healthcare
Industry: Biotechnology

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At a glance:
Bull Thesis:
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Main Competitors:
Moat:
Income Statements:
Quarterly
Annual
    Unit: USD2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 
                               
      revenues:
                               
      product revenues
    42,550,000 46,712,000 41,820,000 37,320,000 33,222,000 32,880,000 32,318,000 31,497,000 28,809,000 23,697,000 21,682,000 22,048,000 19,962,000 19,472,000 15,164,000 4,825,000            
      collaboration revenues
    2,449,000 1,582,000 1,493,000 984,000 223,000 3,465,000 3,656,000 997,000 414,000 502,000 1,538,000 1,525,000 5,194,000 14,000 285,000 2,265,000            
      total revenues
    44,999,000 48,294,000 43,313,000 38,304,000 33,445,000 36,345,000 35,974,000 32,494,000 29,223,000 24,199,000 23,220,000 23,573,000 25,156,000 19,486,000 15,449,000 7,090,000            
      yoy
    34.55% 32.88% 20.40% 17.88% 14.45% 50.19% 54.93% 37.84% 16.17% 24.19% 50.30% 232.48%                
      qoq
    -6.82% 11.50% 13.08% 14.53% -7.98% 1.03% 10.71% 11.19% 20.76% 4.22% -1.50% -6.29% 29.10% 26.13% 117.90%             
      cost and operating expenses:
                               
      cost of sales
    2,088,000 1,785,000 1,286,000 173,000 488,000 3,245,000 3,344,000 1,799,000 382,000 518,000 917,000 1,275,000 222,000 127,000 90,000 8,000            
      research and development
    57,834,000 58,599,000 62,463,000 58,296,000 54,765,000 48,066,000 47,485,000 44,858,000 47,412,000 74,931,000 66,444,000 59,984,000 55,681,000 52,288,000 49,213,000 46,081,000 51,388,000 46,636,000 40,374,000 34,811,000 35,789,000 27,356,000 20,630,000 17,976,000 16,925,000 15,658,000 9,751,000 
      selling, general, and administrative
    33,924,000 39,148,000 33,252,000 32,610,000 31,449,000 32,195,000 30,026,000 29,625,000 28,321,000 37,151,000 35,527,000 32,828,000 30,747,000 30,070,000 30,143,000 29,933,000 23,936,000           
      total cost and operating expenses
    93,846,000 99,532,000 97,001,000 91,079,000 86,702,000 83,506,000 80,855,000 76,282,000 76,115,000 112,600,000 102,888,000 94,087,000 86,650,000 82,485,000 79,446,000 76,022,000            
      income from operations
    -48,847,000 -51,238,000 -53,688,000 -52,775,000 -53,257,000 -47,161,000 -44,881,000 -43,788,000 -46,892,000 -88,401,000 -79,668,000 -70,514,000 -61,494,000 -62,999,000 -63,997,000 -68,932,000 -75,262,000 -70,373,000 -58,353,000 -22,975,000 -49,025,000 -33,830,000 -25,889,000 -22,429,000 -21,951,000 -20,338,000 -12,181,000 
      yoy
    -8.28% 8.64% 19.62% 20.52% 13.57% -46.65% -43.66% -37.90% -23.75% 40.32% 24.49% 2.30% -18.29% -10.48% 9.67% 200.03% 53.52% 108.02% 125.40% 2.43% 123.34% 66.34% 112.54%     
      qoq
    -4.67% -4.56% 1.73% -0.91% 12.93% 5.08% 2.50% -6.62% -46.96% 10.96% 12.98% 14.67% -2.39% -1.56% -7.16% -8.41% 6.95% 20.60% 153.98% -53.14% 44.92% 30.67% 15.43% 2.18% 7.93% 66.96%  
      operating margin %
    -108.55% -106.10% -123.95% -137.78% -159.24% -129.76% -124.76% -134.76% -160.46% -365.31% -343.10% -299.13% -244.45% -323.30% -414.25% -972.24% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% 
      other income:
                               
      interest and other income
    3,764,000 4,479,000 4,107,000 4,213,000 3,648,000 1,948,000 1,838,000 727,000  6,000 -170,000 81,000 196,000 259,000 296,000 1,691,000 2,455,000 3,169,000 2,174,000 1,540,000 1,654,000 1,551,000 1,475,000 760,000 543,000   
      total other income
    3,764,000 4,479,000 4,107,000 4,213,000 3,648,000 1,948,000 1,838,000 727,000  6,000 -170,000 81,000 196,000 259,000 296,000 1,691,000 2,455,000 3,157,000 2,157,000 1,515,000 1,641,000 1,531,000 1,454,000 739,000 521,000 426,000 143,000 
      net income
    -45,083,000 -47,190,000 -49,581,000 -48,562,000 -49,609,000 -45,935,000 -43,043,000 -43,061,000 -46,892,000 -88,395,000 -79,838,000 -70,433,000 -61,298,000 -62,740,000 -63,701,000 -67,241,000 -72,807,000 -67,216,000 -56,196,000 -21,460,000 -47,384,000       
      yoy
    -9.12% 2.73% 15.19% 12.77% 5.79% -48.03% -46.09% -38.86% -23.50% 40.89% 25.33% 4.75% -15.81% -6.66% 13.36% 213.33% 53.65%           
      qoq
    -4.46% -4.82% 2.10% -2.11% 8.00% 6.72% -0.04% -8.17% -46.95% 10.72% 13.35% 14.90% -2.30% -1.51% -5.26% -7.64% 8.32% 19.61% 161.86% -54.71%        
      net income margin %
    -100.19% -97.71% -114.47% -126.78% -148.33% -126.39% -119.65% -132.52% -160.46% -365.28% -343.83% -298.79% -243.67% -321.97% -412.33% -948.39% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% NaN% NaN% NaN% NaN% NaN% NaN% 
      net income per share
    -0.52 -0.54 -0.58 -0.57 -0.6 -0.55 -0.55 -0.6 -0.8 -1.51 -1.37 -1.21 -1.06 -1.1 -1.13 -1.2 -1.36 -1.36 -1.28 -0.56 -1.25 -0.87 -0.65 -0.65 -0.66 11.77 -5.85 
      weighted-average common shares outstanding—basic and diluted
    87,388,106 85,059,962 85,788,613 85,020,344 82,676,624 75,500,148 78,206,647 72,133,428 58,616,458 58,084,325 58,107,611 57,987,095 57,747,168 55,780,982 56,390,748 55,920,122 53,567,434 42,869,058 43,803,508 38,200,288 38,057,018 35,390,480 37,654,324 33,567,314 32,594,074 16,792,179  
      comprehensive loss:
                               
      other comprehensive income:
                               
      unrealized gains on marketable securities
    -206 978 250      -540 -246 -9  30 -28 47 -771 652 50 -114 154 21       
      currency translation adjustment
    -273 495 -179 108 93 432 -352 -48 -74 132 148 36               
      total other comprehensive income
    -479 1,473 71 -786 802 1,059 -774 -705 -614 -114 139 -17 32 -28 47 -771 652 50 -114 154 21       
      total comprehensive loss
    -45,562 -45,717 -49,510 -49,348 -48,807 -44,876 -43,817 -43,766 -47,506 -88,509 -79,699 -70,450 -61,266 -62,768 -63,654 -68,012 -72,155 -67,166 -56,310 -21,306 -47,363       
      unrealized losses on marketable securities
       -894 709 627 -422 -657    -53                
      interest expense
                     -12,000 -17,000 -25,000 -13,000 -20,000 -21,000 -21,000 -22,000 -23,000 -23,000 
      revenues
                    62,000           
      operating expenses:
                               
      total operating expenses
                    75,324,000 70,373,000 58,353,000 47,975,000 49,025,000 33,830,000 25,889,000 22,429,000 21,951,000 20,338,000 12,181,000 
      general and administrative
                     11,094,750 17,979,000 13,164,000 13,236,000 6,474,000 5,259,000 4,453,000 5,026,000 4,680,000 2,430,000 
      revenue
                       25,000,000        
      net income and comprehensive loss
                         -32,299,000 -24,435,000 -21,690,000 -21,430,000 -19,912,000 -12,038,000 
      other income
                             74,250 166,000 
      net income attributable to series a convertible preferred shareholders—basic and diluted
                             -7,593,000 -12,038,000 
      weighted-average series a convertible preferred shares outstanding—basic and diluted
                              2,057,750 
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 
                                 
        assets
                                 
        current assets:
                                 
        cash and cash equivalents
      91,228,000 83,507,000 108,087,000 81,394,000 114,637,000 64,741,000 82,538,000 109,698,000 95,332,000 87,063,000 53,189,000 90,947,000 201,648,000 135,897,000 111,154,000 155,446,000 229,652,000 120,320,000 173,712,000 57,237,000 82,228,000 293,764,000 320,875,000 346,527,000 179,873,000 196,754,000 82,149,000 
        short-term marketable securities
      181,299,000 222,709,000 230,988,000 247,346,000 283,996,000 259,745,000 282,039,000 274,149,000 161,221,000 198,571,000 289,081,000 304,405,000 300,527,000 416,033,000 434,171,000 454,890,000            
        accounts receivable
      32,684,000 31,952,000 27,549,000 23,200,000 22,439,000 22,429,000 23,278,000 25,851,000 23,151,000 20,595,000 18,049,000 18,608,000 21,821,000 13,896,000 11,814,000 7,384,000    20,000,000        
        inventory
      21,098,000 21,210,000 27,105,000 25,343,000 25,528,000 20,561,000 19,129,000 20,889,000 19,627,000 14,125,000 7,253,000 8,206,000 7,090,000 5,716,000 4,596,000 1,389,000            
        prepaid expenses and other current assets
      23,628,000 21,718,000 23,847,000 27,767,000 29,559,000 25,482,000 13,895,000 17,944,000 20,504,000 18,660,000 17,722,000 14,977,000 15,546,000 12,489,000 9,723,000 13,977,000 11,979,000 13,832,000 7,700,000 6,010,000 4,103,000 7,273,000 4,734,000 2,221,000 1,241,000 1,428,000 596,000 
        total current assets
      349,937,000 381,096,000 417,576,000 405,050,000 476,159,000 392,958,000 420,879,000 448,531,000 319,835,000 339,014,000 385,294,000 437,143,000 546,632,000 584,031,000 571,458,000 633,086,000 703,479,000 593,408,000 642,295,000 256,426,000 266,445,000 301,037,000 325,609,000 348,748,000 181,114,000 198,182,000 82,745,000 
        long-term marketable securities
      26,778,000 46,699,000 37,850,000 60,683,000 27,627,000 14,550,000 7,006,000 9,208,000 18,853,000 41,950,000 49,926,000 55,605,000  9,375,000 38,989,000 21,431,000            
        other long-term assets and long-term investments—restricted
      8,133,000                           
        property and equipment
      5,155,000 5,421,000 5,864,000 6,213,000 6,511,000 6,707,000 7,152,000 7,353,000 7,821,000 8,610,000 10,820,000 9,588,000 9,633,000 9,583,000 9,925,000 9,567,000 6,693,000 6,333,000 5,274,000 1,595,000 1,504,000 13,453,000 19,238,000 18,264,000 952,000 838,000 731,000 
        operating lease assets
      30,925,000 32,073,000 33,209,000 34,333,000 35,445,000 36,547,000 37,639,000 38,676,000 35,846,000 36,800,000 34,276,000 35,128,000 35,879,000 36,341,000 37,171,000 20,096,000 20,630,000 21,158,000 522,000         
        total assets
      420,928,000 473,566,000 497,836,000 509,618,000 549,019,000 454,039,000 475,952,000 507,037,000 385,464,000 429,484,000 483,418,000 540,566,000 595,246,000 642,432,000 659,668,000 686,305,000 732,927,000 622,409,000 649,601,000 260,007,000 269,688,000 315,559,000 345,916,000 368,156,000 182,141,000 199,095,000 87,867,000 
        liabilities and stockholders' equity
                                 
        current liabilities:
                                 
        accounts payable
      19,459,000 26,476,000 21,453,000 18,211,000 19,670,000 18,612,000 12,800,000 16,229,000 17,801,000 13,130,000 13,502,000 14,022,000 11,905,000 12,308,000 10,237,000 12,582,000 11,337,000 19,575,000 14,770,000 13,900,000 10,937,000 8,308,000 6,051,000 6,938,000 5,556,000 4,395,000 3,104,000 
        accrued expenses and other current liabilities
      60,396,000 70,295,000 68,005,000 59,455,000 60,942,000 64,622,000 59,498,000 55,214,000 65,938,000 80,773,000 59,625,000 49,428,000 49,344,000 55,227,000 48,941,000 37,333,000 32,234,000 38,716,000 26,884,000 20,935,000 16,333,000 14,248,000 11,406,000 11,790,000    
        operating lease liabilities
      3,574,000 3,504,000 3,436,000 3,368,000 3,301,000 3,235,000 3,170,000 3,102,000 2,931,000 2,870,000 2,662,000 2,604,000 2,540,000 2,457,000 2,010,000 1,424,000 1,501,000 1,747,000 415,000 313,000 434,000       
        total current liabilities
      83,429,000 100,275,000 92,894,000 81,034,000 83,913,000 86,469,000 75,468,000 74,545,000 86,670,000 96,773,000 75,789,000 66,054,000 63,789,000 69,992,000 61,188,000 51,339,000 45,072,000 60,038,000 42,256,000 35,335,000 27,891,000 22,743,000 17,644,000 18,915,000 16,295,000 13,815,000 10,080,000 
        operating lease liabilities, net of current portion
      21,449,000 22,375,000 23,272,000 24,154,000 25,022,000 25,879,000 26,708,000 27,481,000 27,229,000 27,991,000 27,172,000 27,856,000 28,444,000 28,764,000 29,394,000 15,282,000 15,595,000 15,904,000 107,000 164,000 244,000       
        total liabilities
      104,878,000 122,650,000 116,166,000 105,188,000 108,935,000 112,348,000 102,176,000 102,026,000 113,899,000 124,764,000 102,961,000 93,910,000 92,233,000 98,756,000 90,582,000 66,621,000 60,667,000 75,942,000 44,048,000 37,129,000 29,692,000 35,578,000 36,548,000 37,059,000 17,551,000 15,122,000 11,439,000 
        commitments and contingencies
                                 
        stockholders' equity:
                                 
        preferred stock, 0.01 par value per share...
                                 
        common stock, 0.01 par value per share...
      821,000 805,000 799,000 788,000 785,000 676,000 674,000 668,000 586,000 585,000 583,000 580,000 579,000 576,000 566,000 561,000 557,000 516,000 510,000 382,000 382,000 377,000 377,000 376,000 326,000 326,000  
        additional paid-in capital
      1,788,519,000 1,777,839,000 1,762,882,000 1,736,143,000 1,722,452,000 1,575,361,000 1,562,572,000 1,549,996,000 1,372,866,000 1,358,516,000 1,345,746,000 1,332,249,000 1,318,157,000 1,297,557,000 1,260,209,000 1,247,158,000 1,231,726,000 1,033,819,000 1,025,745,000 586,888,000 582,700,000 575,327,000 572,415,000 569,710,000 381,563,000 379,516,000 7,847,000 
        accumulated other comprehensive income
      98,000 577,000 -896,000 -967,000 -181,000 -983,000 -2,042,000 -1,268,000 -563,000 51,000 165,000 26,000 43,000 11,000 39,000 -8,000 763,000 111,000 61,000 175,000 21,000       
        accumulated deficit
      -1,473,388,000 -1,428,305,000 -1,381,115,000 -1,331,534,000 -1,282,972,000 -1,233,363,000 -1,187,428,000 -1,144,385,000 -1,101,324,000 -1,054,432,000 -966,037,000 -886,199,000 -815,766,000 -754,468,000 -691,728,000 -628,027,000 -560,786,000 -487,979,000 -420,763,000 -364,567,000 -343,107,000 -295,723,000 -263,424,000 -238,989,000 -217,299,000 -195,869,000 -175,957,000 
        total stockholders' equity
      316,050,000 350,916,000 381,670,000 404,430,000 440,084,000 341,691,000 373,776,000 405,011,000 271,565,000 304,720,000 380,457,000 446,656,000 503,013,000 543,676,000 569,086,000 619,684,000 672,260,000 546,467,000          
        total liabilities and stockholders' equity
      420,928,000 473,566,000 497,836,000 509,618,000 549,019,000 454,039,000 475,952,000 507,037,000 385,464,000 429,484,000 483,418,000 540,566,000 595,246,000 642,432,000 659,668,000 686,305,000 732,927,000 622,409,000          
        long-term investments—restricted and other long-term assets
       8,277,000 3,337,000 3,339,000 3,277,000 3,277,000 3,276,000 3,269,000                    
        long-term investments—restricted
              3,109,000 3,110,000 3,102,000 3,102,000 3,102,000 3,102,000 2,125,000 2,125,000        1,069,000    
        marketable securities
                      461,848,000 459,256,000 460,883,000 168,179,000 180,114,000       
        long-term investment—restricted
                      2,125,000 1,510,000 1,510,000 1,510,000 1,069,000 1,069,000 1,069,000     
        notes payable to related party
                        187,000 187,000 187,000 187,000 187,000 187,000 187,000 187,000 187,000 
        notes payable to related party, net of current portion
                        967,000 1,014,000 1,076,000 1,107,000 1,154,000 1,201,000 1,248,000 1,294,000 1,341,000 
        other long-term liabilities
                        718,000 616,000 481,000 381,000 212,000 47,000 8,000 13,000 18,000 
        liabilities and stockholders’ equity
                                 
        stockholders’ equity:
                                 
        total stockholders’ equity
                        605,553,000 222,878,000 239,996,000 279,981,000 309,368,000 331,097,000 164,590,000   
        total liabilities and stockholders’ equity
                        649,601,000 260,007,000 269,688,000 315,559,000 345,916,000 368,156,000 182,141,000   
        unbilled receivable
                         5,000,000        
        operating lease, right-of-use assets
                         476,000 670,000       
        other assets
                             75,000 75,000 75,000 75,000 
        lease liability, net of current portion
                           11,347,000 17,538,000 16,896,000    
        accrued expenses
                              10,552,000 9,233,000 6,789,000 
        deferred offering costs
                                4,316,000 
        liabilities, convertible preferred shares and stockholders’ equity/members’ deficit
                                 
        convertible preferred shares (series a, b-1, b-2, c), no par value; no shares and 3,632,711 authorized as of december 31, 2017 and 2016, respectively; no shares and 3,632,711 shares issued and outstanding as of december 31, 2017 and 2016
                                 
        stockholders’ equity/members’ deficit:
                                 
        common shares, no par value; no shares and 4,366,052 shares authorized as of december 31, 2017 and 2016, respectively; no shares issued or outstanding as of december 31, 2017 and 2016
                                 
        total stockholders’ equity/members’ deficit
                               183,973,000  
        total liabilities, convertible preferred shares and stockholders’ equity/members’ deficit
                               199,095,000  
        liabilities, convertible preferred shares and members’ deficit
                                 
        convertible preferred shares (series a, b-1, b-2, c), no par value; 4,455,039 shares authorized at september 30, 2017 and 3,632,711 shares authorized as of december 31, 2016; 4,323,044 shares issued and outstanding as of september 30, 2017, 3,632,711 shares issued and outstanding as of december 31, 2016; aggregate liquidation preference of 246,388 as of september 30, 2017 and 194,088 as of december 31, 2016
                                244,538,000 
        members’ deficit:
                                 
        common shares, no par value; 5,217,929 shares authorized as of september 30, 2017 and 4,366,052 shares authorized as of december 31, 2016; no shares issued or outstanding as of september 30, 2017 or december 31, 2016
                                 
        total members’ deficit
                                -168,110,000 
        total liabilities, convertible preferred shares and members’ deficit
                                87,867,000 
        revenue
                                 
        operating expenses:
                                 
        research and development
                                9,751,000 
        general and administrative
                                2,430,000 
        total operating expenses
                                12,181,000 
        income from operations
                                -12,181,000 
        other income:
                                 
        interest expense
                                -23,000 
        other income
                                166,000 
        total other income
                                143,000 
        net income and comprehensive loss
                                -12,038,000 
        net income attributable to series a convertible preferred shareholders—basic and diluted
                                -12,038,000 
        net income per share
                                -5,850 
        weighted-average series a convertible preferred shares outstanding—basic and diluted
                                2,057,750,000 
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 
                                  
          cash flows from operating activities:
                                  
          net income
        -45,083,000 -47,190,000 -49,581,000 -48,562,000 -49,609,000 -45,935,000 -43,043,000 -43,061,000 -46,892,000 -88,395,000 -79,838,000 -70,433,000 -61,298,000 -62,740,000 -63,701,000 -67,241,000 -72,807,000 -67,216,000 -56,196,000 -21,460,000 -47,384,000 -32,299,000 -24,435,000 -21,690,000 -21,430,000 -19,912,000 
          adjustments to reconcile net income to net cash flows used in operating activities:
                                  
          stock-based compensation expense
        10,174,000 14,073,000 11,160,000 12,856,000 12,514,000 12,313,000 12,373,000 12,988,000 14,268,000 10,794,000 11,794,000 12,371,000 11,119,000 9,706,000 9,828,000 10,609,000 6,994,000 5,345,000 4,729,000 4,107,000 6,229,000 2,805,000 2,614,000    
          depreciation expense
        450,000 456,000 465,000 571,000 608,000 601,000 742,000 820,000 783,000 780,000 759,000 743,000 732,000 695,000 666,000 484,000 460,000          
          noncash lease expense
        1,147,000 1,136,000 1,124,000 1,113,000 1,102,000 1,091,000 1,081,000 1,000,000 954,000 919,000 852,000 842,000 833,000 886,000 886,000            
          net amortization of (discounts) premium on marketable securities
        -1,653,000   -1,953,000 -1,566,000                      
          changes in operating assets and liabilities:
                                  
          accounts receivable
        -878,000 -4,167,000 -4,489,000 -766,000 77,000 1,230,000 2,383,000 -2,836,000 -2,561,000 -2,546,000 559,000 3,213,000 -7,925,000 -2,082,000 -4,430,000            
          inventory
        -918,000 972,000 3,531,000 -3,631,000 -1,258,000 -3,363,000 3,165,000 -1,443,000 -5,468,000 -6,880,000 881,000 -6,129,000 1,973,000 -786,000 -1,657,000            
          prepaid expenses and other current assets
        -1,967,000 2,171,000 3,901,000 1,797,000 -4,061,000 -11,544,000 4,026,000 -148,000 -1,844,000 -2,694,000 -2,751,000 568,000 -3,057,000 -2,802,000 1,176,000 -1,999,000 1,853,000 -9,894,000 -1,690,000 -1,907,000 3,170,000 -2,539,000 -2,438,000 -980,000 187,000 -832,000 
          other long-term assets
        140,000 -4,935,000   -1,000 -7,000                    
          accounts payable
        -6,944,000 4,933,000 3,272,000 -1,421,000 993,000 5,569,000 -3,386,000 -1,549,000 4,685,000 -345,000 -533,000 2,144,000 -433,000 2,375,000 -2,852,000 1,455,000 -8,511,000 4,400,000 870,000 2,963,000 2,629,000 2,257,000 -491,000 1,083,000 1,142,000 1,465,000 
          accrued expenses and other current liabilities
        -8,196,000 5,992,000 3,649,000 2,234,000 -7,464,000 5,829,000 3,199,000 -10,382,000 -14,830,000 21,462,000 10,359,000 4,848,000 -9,384,000 5,584,000 10,775,000 4,364,000 -6,800,000 12,151,000 4,799,000 4,602,000 2,637,000 2,640,000 -435,000    
          operating lease liabilities
        -857,000 -829,000 -813,000 -803,000 -791,000 -763,000 -749,000 -720,000 -702,000 -661,000 -626,000 -616,000 -607,000 -203,000 -185,000 -390,000 -555,000 127,000 -97,000 -201,000 -148,000      
          net cash flows used in operating activities
        -54,585,000 -28,809,000 -29,807,000 -38,626,000 -49,455,000 -35,158,000 -20,828,000 -45,524,000 -51,352,000 -67,176,000 -53,999,000 -51,967,000 -67,682,000 -49,128,000 -49,341,000 -60,844,000 -80,370,000 -55,833,000         
          cash flows from investing activities:
                                  
          purchases of marketable securities
        -20,264,000 -59,657,000 -33,780,000 -106,275,000 -122,860,000 -82,175,000 -58,707,000   -21,657,000 -101,597,000 -180,296,000 -31,825,000 -127,764,000 -150,823,000 -614,655,000 -203,527,000 -198,952,000 -364,431,000 -74,152,000 -179,607,000      
          maturities of marketable securities
        83,041,000 61,919,000 75,245,000 110,929,000 87,021,000 98,460,000 53,209,000 77,978,000 59,652,000 108,511,000 99,464,000 104,242,000 156,370,000 175,250,000 129,400,000 120,143,000 203,120,000          
          sales of marketable securities
         785,000     10,996,000 22,584,000   24,470,000            
          purchases of property and equipment
        -146,000 -63,000 -62,000 -293,000 -360,000 19,000 -573,000   1,109,000 -2,010,000 -432,000 -637,000 -430,000 -1,233,000 -2,984,000 -669,000 -1,725,000 -2,966,000 -203,000 -41,000 -303,000 -216,000 -455,000 -151,000 -130,000 
          net cash flows from investing activities
        62,631,000 2,199,000   -35,414,000 16,304,000 -6,071,000 -104,194,000 59,652,000 98,952,000 14,441,000 -60,453,000 123,908,000              
          cash flows from financing activities:
                                  
          proceeds from offerings of common stock, net of underwriting discounts and commissions
         14,622,000 135,125,000     1,000 8,588,000              
          proceeds from pre-funded warrant exercise
        9,000  24,000  6,000                    
          payments of offering costs
          -634,000                    
          proceeds from stock option exercises and employee stock purchase plan
        513,000 890,000 968,000 838,000 171,000 478,000 203,000 868,000 83,000 1,977,000 1,706,000                
          net cash flows from financing activities
        522,000 890,000 15,590,000 838,000 134,686,000 478,000 209,000 164,224,000 83,000 1,978,000 1,706,000 1,682,000 9,524,000 27,792,000 3,228,000 4,389,000 191,392,000 761,000         
          net increase in cash and cash equivalents
        8,568,000 -25,720,000 27,186,000 -33,427,000 49,817,000   14,506,000 8,383,000   -110,738,000 65,750,000 24,743,000 -44,292,000 -74,206,000 109,332,000 -53,392,000 116,475,000   -27,111,000 -25,652,000   114,605,000 
          effect of exchange rate changes on cash and cash equivalents
        -847,000 1,140,000 -493,000 184,000 79,000 579,000 -470,000 -140,000 -114,000 120,000 94,000 37,000 1,000              
          cash and cash equivalents at beginning of period
        83,507,000 64,741,000 87,063,000 135,897,000 120,320,000 293,764,000 196,754,000 
          cash and cash equivalents at end of period
        91,228,000 -24,580,000 26,693,000 -33,243,000 114,637,000 -17,797,000 -27,160,000 14,366,000 95,332,000 33,874,000 -37,758,000 -110,701,000 201,648,000 24,743,000 -44,292,000 -74,206,000 229,652,000 -53,392,000 116,475,000 -24,991,000 82,228,000 -27,111,000 -25,652,000 166,654,000 179,873,000 114,605,000 
          adjustments to reconcile net income to net cash from operating activities:
                                  
          acquired in-process research and development
                                 
          net amortization (accretion) of premiums (discounts) on marketable securities
                                  
          income tax liabilities
                                  
          increase in restricted investments
                     -977,000 -1,000 -614,000      
          proceeds from pre-funded warrants
                                  
          payments of public offering costs
                     -163,000 -300,000 -352,000 -267,000        
          net accretion of discounts on marketable securities
                     239,000 160,000 -478,000 -1,532,000 -1,729,000 -973,000 -811,000 -486,000      
          net cash flows used in investing activities
                      1,821,000 -17,751,000 -1,690,000 1,680,000         
          gain on disposal of equipment
                                  
          proceeds from sale of equipment
                                 
          proceeds from offerings of common stock and pre-funded warrants, net of underwriting discounts and commissions
                                 
          net decrease in cash and cash equivalents
                            -211,536,000    -16,881,000  
          net amortization (accretion) of premium (discounts) on marketable securities
               -33,000 255,000  545,000 482,000 365,000              
          other long-term liabilities
                         13,000 102,000 135,000 100,000 169,000 165,000 39,000 -5,000 -5,000 
          repayment of notes payable to related party
                         -1,154,000 -47,000 -62,000 -31,000 -47,000 -47,000 -47,000 -46,000 -47,000 
          supplemental disclosure of cash flow information:
                                  
          cash paid for interest
                         12,000 17,000 25,000 13,000 20,000 21,000 21,000 22,000 23,000 
          addition of operating lease asset included in accrued expenses and other current liabilities
                                  
          supplemental disclosure of non-cash investing and financing activities:
                                  
          purchases of property and equipment included in accounts payable and accrued expenses and other current liabilities
                                  
          unsettled exercise of stock options
                                  
          (gain) loss on disposal of equipment
                                  
          operating lease liabilities arising from obtaining operating lease assets
                                  
          proceeds from exercise of stock options
                    936,000  3,228,000 4,827,000 2,569,000 2,182,000 2,476,000 81,000 1,149,000 107,000 91,000 707,000 10,000  
          proceeds from public offerings, net of underwriting discounts and commissions
                     18,194,000 -138,000 189,175,000         
          amounts capitalized under build-to-suit lease transaction
                             -5,989,000 846,000    
          property and equipment purchases included in accounts payable and accrued expenses and other current liabilities
                      -209,000 373,000 152,000          
          offering costs included in accounts payable and accrued expenses and other current liabilities
                        438,000          
          unbilled receivables
                                  
          inventory purchases included in accrued expenses and other current liabilities
                                  
          operating lease assets
                        528,000 525,000         
          loss on disposal of property and equipment
                                 
          proceeds from issuance of convertible preferred shares
                                 
          payments of convertible preferred share issuance costs
                                 
          retirement of assets
                                  
          conversion of convertible preferred shares into common stock
                                  
          depreciation and amortization expense
                          169,000 112,000 104,000 99,000 88,000 74,000 56,000 49,000 
          maturities and sales of marketable securities
                          72,587,000        
          amounts capitalized under build-to-suit lease transactions
                                  
          property and equipment purchases included in accrued expenses and other current liabilities
                                  
          offering costs included in accrued expenses and other current liabilities
                                  
          unbilled receivable
                                  
          operating lease, right-of-use assets
                           194,000 143,000      
          net cash from operating activities
                           -37,266,000 -33,006,000 -26,868,000 -24,932,000 -18,289,000 -16,694,000 -12,753,000 
          capital expenditures
                           -203,000  -303,000 -216,000 -455,000 -54,000 -130,000 
          free cash flows
                           -37,469,000  -27,171,000 -25,148,000 -18,744,000 -16,748,000 -12,883,000 
          net cash from investing activities
                           12,256,000 -179,648,000 -303,000 -216,000 -1,524,000 -151,000 -130,000 
          net cash from financing activities
                           19,000 1,118,000 60,000 -504,000   127,488,000 
          supplemental disclosure of non-cash investing activities:
                                  
          supplemental disclosure of non-cash financing activities:
                                  
          offering costs included in accounts payable and accrued expenses
                                  
          purchases of property and equipment included in accounts payable and accrued expenses
                                  
          other assets
                                  
          proceeds from follow-on public offering, net of underwriting discounts and commissions
                              1,000    
          purchases of property and equipment included in accounts payable
                                97,000  
          offering costs included in accounts payable or accrued expenses
                                  
          payments of follow-on public offering costs
                                  
          payments of initial public offering costs
                                 -1,577,000 
          share-based compensation expense
                                2,037,000 2,844,000 
          accrued expenses
                                1,319,000 3,638,000 
          net cash used by financing activities
                                -36,000  
          deferred offering costs included in accounts payable or accrued expenses
                                  
          non-cash interest expense
                                  
          proceeds from initial public offering, net of underwriting discounts and commissions
                                  
          proceeds from issuance of convertible notes payable to related parties
                                  
          conversion of notes payable and accrued interest into convertible preferred shares
                                  
          conversion of member units into series a convertible preferred shares
                                  
          gain on extinguishment of notes payable to related party
                                  
          purchases of property and equipment included in accounts payable or accrued expenses