BioMarin Pharmaceutical Inc
(NASDAQ:BMRN)

BioMarin Pharmaceutical Inc., a biotechnology company, develops and commercializes therapies for people with serious and life-threatening rare diseases and medical conditions. Its commercial products include Aldurazyme to treat mucopolysaccharidosis I, a genetic disease; Brineura for the treatment o...

Website: http://www.biomarin.com

Founded: 1997

Full Time Employees: 3,001

Sector: Healthcare

Industry: Biotechnology

Pharmaceuticals

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Quarterly

Annual

Unit: USD	2026-03-31	2025-12-31	2025-09-30	2025-06-30	2025-03-31	2024-12-31	2024-09-30	2024-06-30	2024-03-31	2023-12-31	2023-09-30	2023-06-30	2023-03-31	2022-12-31	2022-09-30	2022-06-30	2022-03-31	2021-12-31	2021-09-30	2021-06-30	2021-03-31	2020-12-31	2020-09-30	2020-06-30	2020-03-31	2019-12-31	2019-09-30	2019-06-30	2019-03-31	2018-12-31	2018-09-30	2018-06-30	2018-03-31	2017-12-31	2017-09-30	2017-06-30	2017-03-31	2016-12-31	2016-09-30	2016-06-30	2016-03-31	2015-12-31	2015-09-30	2015-06-30	2015-03-31	2014-12-31	2014-09-30	2014-06-30	2014-03-31	2013-12-31	2013-09-30	2013-06-30	2013-03-31	2012-12-31	2012-09-30	2012-06-30	2012-03-31	2011-12-31	2011-09-30	2011-06-30	2011-03-31	2010-12-31	2010-09-30	2010-06-30	2010-03-31	2009-12-31	2009-09-30	2009-06-30	2009-03-31	2008-12-31	2008-09-30	2008-06-30	2008-03-31	2007-12-31	2007-09-30	2007-06-30	2007-03-31	2006-12-31

revenues:
net product revenues	760,078,000	859,321,000	760,812,000	812,982,000	734,644,000	735,634,000	733,867,000	702,129,000	637,815,000	633,148,000	568,266,000	584,698,000	586,426,000	525,492,000	493,348,000	517,660,000	505,525,000	435,219,000	393,840,000	486,670,000	467,769,000	437,045,000	460,741,000	419,032,000	489,043,000	436,585,000	450,900,000	379,075,000	394,483,000	347,151,000	386,320,000	367,786,000	369,099,000	353,577,000	298,752,000	315,926,000	302,190,000	298,186,000	278,262,000	298,576,000	235,357,000	226,420,000	207,767,000	249,023,000	201,312,000	227,752,000	173,416,000	188,244,000	149,004,000	144,286,000	134,330,000	132,400,000	127,344,000	130,957,000	126,310,000	122,991,000	116,239,000	106,064,000	112,891,000	109,616,000	109,076,000	98,477,000	96,559,000	90,592,000	84,073,000	83,952,000	78,383,000	81,472,000	71,914,000	65,956,000	67,812,000	60,458,000	57,625,000
royalty and other revenues	6,130,000	15,244,000	15,321,000	12,428,000	10,501,000	11,679,000	11,873,000	9,900,000	11,018,000	13,059,000	13,063,000	10,577,000	9,989,000	12,046,000	11,996,000	16,138,000	13,834,000	14,591,000	14,902,000	15,023,000	18,261,000	15,072,000	16,043,000	10,453,000	13,026,000	17,858,000	10,197,000	8,688,000	6,262,000	6,063,000	5,386,000	5,059,000	4,348,000	4,728,000	35,396,000	1,522,000	1,555,000
total revenues	766,208,000	874,565,000	776,133,000	825,410,000	745,145,000	747,313,000	745,740,000	712,029,000	648,833,000	646,207,000	581,329,000	595,275,000	596,415,000	537,538,000	505,344,000	533,798,000	519,359,000	449,810,000	408,742,000	501,693,000	486,030,000	452,117,000	476,784,000	429,485,000	502,069,000	454,443,000	461,097,000	387,763,000	400,745,000	353,214,000	391,706,000	372,845,000	373,447,000	358,305,000	334,148,000	317,448,000	303,745,000	300,091,000	279,896,000	300,131,000	236,736,000	227,936,000	208,904,000	250,523,000	203,264,000	230,854,000	176,847,000	191,787,000	151,552,000	146,873,000	136,874,000	136,810,000	127,928,000	131,938,000	128,117,000	124,019,000	116,649,000	107,846,000	113,425,000	110,631,000	109,456,000	101,614,000	97,750,000	91,950,000	84,953,000	87,082,000	80,807,000	82,787,000	73,980,000	99,276,000	72,646,000	64,174,000	60,396,000	44,854,000	25,006,000	28,884,000	22,838,000
yoy	2.83%	17.03%	4.08%	15.92%	14.84%	15.65%	28.28%	19.61%	8.79%	20.22%	15.04%	11.52%	14.84%	19.50%	23.63%	6.40%	6.86%	-0.51%	-14.27%	16.81%	-3.19%	-0.51%	3.40%	10.76%	25.28%	28.66%	17.72%	4.00%	7.31%	-1.42%	17.23%	17.45%	22.95%	19.40%	19.38%	5.77%	28.31%	31.66%	33.98%	19.80%	16.47%	-1.26%	18.13%	30.63%	34.12%	57.18%	29.20%	40.18%	18.47%	11.32%	6.84%	10.31%	9.67%	22.34%	12.95%	12.10%	6.57%	6.13%	16.04%	20.32%	28.84%	16.69%	20.97%	11.07%	14.83%	-12.28%	11.23%	29.00%	22.49%	121.33%	190.51%	122.18%	164.45%
qoq	-12.39%	12.68%	-5.97%	10.77%	-0.29%	0.21%	4.73%	9.74%	0.41%	11.16%	-2.34%	-0.19%	10.95%	6.37%	-5.33%	2.78%	15.46%	10.05%	-18.53%	3.22%	7.50%	-5.17%	11.01%	-14.46%	10.48%	-1.44%	18.91%	-3.24%	13.46%	-9.83%	5.06%	-0.16%	4.23%	7.23%	5.26%	4.51%	1.22%	7.22%	-6.74%	26.78%	3.86%	9.11%	-16.61%	23.25%	-11.95%	30.54%	-7.79%	26.55%	3.19%	7.31%	0.05%	6.94%	-3.04%	2.98%	3.30%	6.32%	8.16%	-4.92%	2.53%	1.07%	7.72%	3.95%	6.31%	8.24%	-2.44%	7.77%	-2.39%	11.90%	-25.48%	36.66%	13.20%	6.26%	34.65%	79.37%	-13.43%	26.47%
operating expenses:
cost of sales	194,999,000	275,709,000	140,085,000	150,090,000	151,558,000	136,139,000	188,457,000	130,459,000	125,180,000	135,478,000	124,745,000	128,082,000	126,549,000	127,290,000	116,288,000	123,126,000	116,965,000	119,750,000	103,537,000	127,062,000	120,166,000	126,138,000	188,793,000	97,967,000	111,374,000	95,899,000	96,949,000	77,436,000	89,182,000	75,019,000	78,893,000	79,019,000	82,333,000	75,995,000	59,480,000	56,305,000	50,006,000	64,147,000	50,738,000	51,617,000	43,118,000	42,598,000	36,719,000	39,878,000	32,813,000	45,818,000	29,920,000	31,210,000	22,816,000	24,621,000	28,054,000	22,567,000	20,500,000	26,532,000	24,619,000	23,574,000	17,105,000	21,519,000	22,445,000	19,263,000	20,796,000	20,469,000	18,003,000	14,401,000	17,412,000	16,729,000	14,970,000	19,848,000	14,362,000	11,665,000	14,063,000	9,593,000	17,188,000	5,224,000	4,460,000	4,557,000	4,117,000
research and development	178,796,000	192,413,000	409,478,000	161,308,000	158,731,000	173,509,000	184,901,000	183,787,000	204,987,000	206,250,000	191,314,000	177,363,000	171,846,000	172,751,000	157,829,000	158,190,000	160,836,000	161,092,000	157,869,000	161,107,000	148,725,000	156,667,000	147,053,000	182,139,000	142,257,000	172,812,000	172,963,000	185,641,000	183,591,000	175,390,000	161,408,000	175,582,000	183,948,000	168,608,000	154,103,000	143,039,000	145,003,000	175,242,000	160,831,000	167,039,000	158,793,000	176,118,000	158,713,000	157,901,000	142,074,000	141,989,000	125,686,000	107,702,000	86,166,000	97,312,000	88,064,000	85,661,000	83,743,000	84,363,000	66,209,000	77,812,000	73,834,000	57,908,000	58,577,000	52,909,000	45,017,000	42,197,000	39,366,000	35,649,000	30,097,000	27,443,000	26,991,000	26,324,000	34,358,000	25,732,000	26,175,000	23,755,000	17,628,000	24,015,000	17,241,000	19,186,000	18,159,000
selling, general and administrative	258,290,000	446,207,000	268,415,000	232,279,000	206,116,000	266,607,000	253,480,000	263,032,000	225,906,000	275,024,000	223,928,000	215,336,000	223,003,000	245,739,000	216,816,000	196,835,000	194,619,000	217,563,000	183,333,000	184,161,000	174,318,000	195,512,000	179,450,000	175,412,000	187,295,000	187,900,000	170,112,000	160,754,000	162,158,000	164,171,000	148,566,000	153,280,000	138,336,000	160,280,000	130,532,000	143,505,000	120,019,000	142,958,000	118,758,000	109,577,000	105,300,000	113,907,000	94,044,000	101,514,000	92,806,000	99,632,000	74,604,000	68,089,000	60,069,000	71,809,000	61,841,000	50,656,000	51,050,000	55,049,000	46,337,000	51,539,000	45,248,000	48,454,000	44,880,000	41,015,000	41,037,000	42,098,000	38,348,000	37,277,000	34,000,000	36,528,000	28,667,000	30,527,000	28,568,000	28,730,000	28,964,000	25,203,000	23,669,000	23,892,000	19,713,000	17,649,000	16,284,000
intangible asset amortization	4,483,000	4,846,000	4,847,000	4,846,000	4,847,000	9,651,000	5,009,000	14,299,000	14,298,000
total operating expenses	636,568,000	919,175,000	822,825,000	548,523,000	521,252,000	585,906,000	631,847,000	591,577,000	560,371,000	631,988,000	555,668,000	536,405,000	537,068,000	562,038,000	507,761,000	494,646,000	382,032,000	515,690,000	461,961,000	490,021,000	460,944,000	496,957,000	532,725,000	470,430,000	397,108,000	463,605,000	457,087,000	429,117,000	454,696,000	391,362,000	407,447,000	398,108,000	417,819,000	300,258,000	347,875,000	356,260,000	323,953,000	389,712,000	339,981,000	872,937,000	317,653,000	126,617,000	290,777,000	314,763,000	269,124,000	289,610,000	165,644,000	210,669,000	178,008,000	199,183,000	187,598,000	156,862,000	160,849,000	178,842,000	138,608,000	154,973,000	138,515,000	129,281,000	128,942,000	109,863,000	107,162,000	104,964,000	99,689,000	88,907,000	82,163,000	80,700,000	70,674,000	78,474,000	78,381,000	67,220,000	70,295,000	59,644,000	59,578,000	54,224,000	42,507,000	42,485,000	39,653,000
income from operations	129,640,000	-44,610,000	-46,692,000	276,887,000	223,893,000	161,407,000	113,893,000	120,452,000	88,462,000	14,219,000	25,661,000	58,870,000	59,347,000	-24,500,000	-2,417,000	39,152,000	137,327,000	-65,880,000	-53,219,000	11,672,000	25,086,000	-44,840,000	-55,941,000	-40,945,000	104,961,000	-9,162,000	4,010,000	-41,354,000	-53,951,000	-38,148,000	-15,741,000	-25,263,000	-44,372,000	58,047,000	-13,727,000	-38,812,000	-20,208,000	-89,621,000	-60,085,000	-572,806,000	-80,917,000	101,319,000	-81,873,000	-64,240,000	-65,860,000	-58,756,000	11,203,000	-18,882,000	-26,456,000	-52,310,000	-50,724,000	-20,052,000	-32,921,000	-46,904,000	-10,491,000	-30,954,000	-21,866,000	-21,435,000	-15,517,000	768,000	2,294,000	-3,350,000	-1,939,000	3,043,000	2,790,000	6,382,000	10,133,000	4,313,000	-4,401,000	32,056,000	2,351,000	4,530,000	818,000	-9,370,000	-17,501,000	-13,601,000	-16,815,000
yoy	-42.10%	-127.64%	-141.00%	129.87%	153.10%	1035.15%	343.84%	104.61%	49.06%	-158.04%	-1161.69%	50.36%	-56.78%	-62.81%	-95.46%	235.44%	447.42%	46.92%	-4.87%	-128.51%	-76.10%	389.41%	-1495.04%	-0.99%	-294.55%	-75.98%	-125.47%	63.69%	21.59%	-165.72%	14.67%	-34.91%	119.58%	-164.77%	-77.15%	-93.22%	-75.03%	-188.45%	-26.61%	791.67%	22.86%	-272.44%	-830.81%	240.22%	148.94%	12.32%	-122.09%	-5.83%	-19.64%	11.53%	383.50%	-35.22%	50.56%	118.82%	-32.39%	-4130.47%	-1053.18%	539.85%	700.26%	-74.76%	-17.78%	-152.49%	-119.14%	-29.45%	-163.39%	-80.09%	331.01%	-4.79%	-638.02%	-442.11%	-113.43%	-133.31%	-104.86%
qoq	-390.61%	-4.46%	-116.86%	23.67%	38.71%	41.72%	-5.45%	36.16%	522.14%	-44.59%	-56.41%	-0.80%	-342.23%	913.65%	-106.17%	-71.49%	-308.45%	23.79%	-555.95%	-53.47%	-155.95%	-19.84%	36.62%	-139.01%	-1245.61%	-328.48%	-109.70%	-23.35%	41.43%	142.35%	-37.69%	-43.07%	-176.44%	-522.87%	-64.63%	92.06%	-77.45%	49.16%	-89.51%	607.89%	-179.86%	-223.75%	27.45%	-2.46%	12.09%	-624.47%	-159.33%	-28.63%	-49.42%	3.13%	152.96%	-39.09%	-29.81%	347.09%	-66.11%	41.56%	2.01%	38.14%	-2120.44%	-66.52%	-168.48%	72.77%	-163.72%	9.07%	-56.28%	-37.02%	134.94%	-198.00%	-113.73%	1263.50%	-48.10%	453.79%	-108.73%	-46.46%	28.67%	-19.11%
operating margin %	16.92%	-5.10%	-6.02%	33.55%	30.05%	21.60%	15.27%	16.92%	13.63%	2.20%	4.41%	9.89%	9.95%	-4.56%	-0.48%	7.33%	26.44%	-14.65%	-13.02%	2.33%	5.16%	-9.92%	-11.73%	-9.53%	20.91%	-2.02%	0.87%	-10.66%	-13.46%	-10.80%	-4.02%	-6.78%	-11.88%	16.20%	-4.11%	-12.23%	-6.65%	-29.86%	-21.47%	-190.85%	-34.18%	44.45%	-39.19%	-25.64%	-32.40%	-25.45%	6.33%	-9.85%	-17.46%	-35.62%	-37.06%	-14.66%	-25.73%	-35.55%	-8.19%	-24.96%	-18.75%	-19.88%	-13.68%	0.69%	2.10%	-3.30%	-1.98%	3.31%	3.28%	7.33%	12.54%	5.21%	-5.95%	32.29%	3.24%	7.06%	1.35%	-20.89%	-69.99%	-47.09%	-73.63%
interest income	22,560,000	19,210,000	17,854,000	18,827,000	19,013,000	17,680,000	18,053,000	19,785,000	19,365,000	18,044,000	15,740,000	12,612,000	11,943,000	8,710,000	4,999,000	2,505,000	1,820,000	1,745,000	1,827,000	4,471,000	2,439,000	3,071,000	4,004,000	4,291,000	5,244,000	5,211,000	5,340,000	5,899,000	6,298,000	5,690,000	6,338,000	5,569,000	5,234,000	4,822,000	3,976,000	2,983,000	3,072,000	2,926,000	1,633,000	1,357,000	1,571,000	1,451,000	1,344,000	1,023,000	683,000	1,644,000	1,435,000	1,735,000	1,123,000	1,141,000	574,000	650,000	718,000	765,000	778,000	536,000	505,000	632,000	722,000	798,000	782,000	919,000	968,000	1,035,000	1,190,000	1,035,000	1,012,000	886,000	2,153,000	3,231,000	3,407,000	4,101,000	5,649,000	7,383,000	7,948,000	6,907,000	3,694,000
interest expense	-14,958,000	-2,778,000	-2,579,000	-2,679,000	-2,863,000	-2,577,000	-2,968,000	-3,574,000	-3,547,000	-6,098,000	-3,779,000	-3,755,000	-3,703,000	-3,626,000	-4,679,000	-3,859,000	-3,806,000	-3,846,000	-3,870,000	-3,817,000	-3,804,000	-4,749,000	-9,597,000	-8,048,000	-6,915,000	-6,930,000	-2,937,000	-6,866,000	-6,727,000	-7,746,000	-12,131,000	-12,225,000	-11,562,000	-11,664,000	-10,884,000	-10,040,000	-10,119,000	-9,732,000	-9,980,000	-9,944,000	-9,843,000	-9,333,000	-9,447,000	-10,002,000	-9,462,000	-9,197,000	-9,118,000	-9,221,000	-9,106,000	-7,593,000	-526,000	-603,000	-1,725,000	-1,930,000	-1,837,000	-1,925,000	-1,947,000	-1,704,000	-2,432,000	-2,072,000	-2,141,000	-2,257,000	-3,008,000	-2,635,000	-2,429,000	-2,715,000	-2,880,000	-4,404,000	-4,087,000	-4,097,000	-4,105,000	-4,081,000	-4,110,000	-4,080,000	-4,109,000	-3,720,000	-2,335,000
other income	3,961,000	1,025,000	5,093,000	4,833,000	-1,954,000	550,750	5,463,000		1,267,000	-6,838,000	4,047,000	3,083,000		1,858,000	193,000	-2,947,000		58,000	8,925,000	2,005,000	858,000	5,262,000	1,239,000	2,508,000	-1,861,000	907,000	3,960,000	470,000	1,608,000	-3,061,000	2,589,000	2,849,000	-172,000	3,688,000	267,000	543,000	3,472,000	4,425,000	1,723,000		198,000			-9,121,000	249,000	347,000	-74,000	-147,000	153,000	638,000	239,000	-123,000	228,000	-1,772,000	125,000	-176,000	36,000
income before income taxes	141,203,000	-27,153,000	-26,324,000	297,868,000	238,089,000	169,639,000	134,441,000	132,136,000	105,547,000	19,327,000	41,669,000	70,810,000	56,757,000	-17,558,000	-1,904,000	34,851,000	134,187,000	-66,574,000	-46,160,000	14,156,000	23,228,000	-40,185,000	-61,216,000	-42,273,000	101,352,000	-9,781,000	9,822,000	-41,895,000	-52,957,000	-43,311,000	-19,413,000	-29,177,000	-50,804,000	54,598,000	-20,621,000	-45,546,000	-24,306,000	-92,166,000	-66,813,000	-582,945,000	-89,126,000	92,965,000	-90,443,000	-82,544,000	-74,703,000	-65,737,000	3,221,000	-27,728,000	-34,624,000	-59,375,000	-52,316,000	-20,291,000	-44,521,000	-50,094,000	-11,761,000	-32,417,000	-24,006,000	-23,116,000	-19,731,000	-1,173,000	393,000	-19,238,000	-4,618,000	579,000	1,787,000	3,881,000	7,585,000	1,834,000	-12,735,000	26,556,000	1,081,000	3,963,000	1,824,000
provision for income taxes	35,676,000	19,420,000	4,420,000	57,336,000	52,403,000	44,696,000	28,361,000	24,962,000	16,885,000	-1,048,000	1,291,000	14,770,000	5,905,000	-17,309,000	4,748,000	7,187,000	13,389,000				5,857,000			-13,090,000	19,971,000				3,516,000									-13,455,000	-24,016,000			24,348,000	483,000	-555,000	-7,202,000									-1,712,250	-6,404,000															135,750	252,000
net income	105,527,000	-46,573,000	-30,744,000	240,532,000	185,686,000	124,943,000	106,080,000	107,174,000	88,662,000	20,375,000	40,378,000	56,040,000	50,852,000	-249,000	-6,652,000	27,664,000	120,798,000	-57,898,000	-36,494,000	12,941,000	17,371,000	22,099,000	784,803,000	-29,183,000	81,381,000	15,024,000	55,036,000	-37,435,000	-56,473,000	-3,650,000	-12,620,000	-16,792,000	-44,149,000	-51,392,000	-12,527,000	-36,833,000	-16,290,000	-78,711,000	-42,797,000	-423,560,000	-85,142,000	68,617,000	-90,926,000	-81,989,000	-67,501,000	-69,797,000	7,445,000	-33,502,000	-38,115,000	-61,990,000	-53,020,000	-21,533,000	-39,810,000	-53,012,000	-5,357,000	-32,006,000	-23,972,000	-26,735,000	-17,653,000	-5,077,000	-4,371,000	-12,189,000	217,334,000	-477,000	1,151,000	4,711,000	6,640,000	1,000	-13,152,000	24,506,000	829,000	3,810,000	1,686,000	2,570,000	-5,216,000	-3,864,000	-9,293,000
yoy	-43.17%	-137.28%	-128.98%	124.43%	109.43%	513.22%	162.72%	91.25%	74.35%	-8282.73%	-707.01%	102.57%	-57.90%	-99.57%	-81.77%	113.77%	595.40%	-361.99%	-104.65%	-144.34%	-78.65%	47.09%	1325.98%	-22.04%	-244.11%	-511.62%	-536.10%	122.93%	27.91%	-92.90%	0.74%	-54.41%	171.02%	-34.71%	-70.73%	-91.30%	-80.87%	-214.71%	-52.93%	416.61%	26.13%	-198.31%	-1321.30%	144.73%	77.10%	12.59%	-114.04%	55.58%	-4.26%	16.94%	889.73%	-32.72%	66.07%	98.29%	-69.65%	530.41%	448.43%	119.34%	-108.12%	964.36%	-479.76%	-358.73%	3173.10%	-47800.00%	-108.75%	-80.78%	700.97%	-99.97%	-880.07%	853.54%	-115.89%	-198.60%	-118.14%
qoq	-326.58%	51.49%	-112.78%	29.54%	48.62%	17.78%	-1.02%	20.88%	335.15%	-49.54%	-27.95%	10.20%	-20522.49%	-96.26%	-124.05%	-77.10%	-308.64%	58.65%	-382.00%	-25.50%	-21.39%	-97.18%	-2789.25%	-135.86%	441.67%	-72.70%	-247.02%	-33.71%	1447.21%	-71.08%	-24.85%	-61.97%	-14.09%	310.25%	-65.99%	126.11%	-79.30%	83.92%	-89.90%	397.47%	-224.08%	-175.46%	10.90%	21.46%	-3.29%	-1037.50%	-122.22%	-12.10%	-38.51%	16.92%	146.23%	-45.91%	-24.90%	889.58%	-83.26%	33.51%	-10.33%	51.45%	247.71%	16.15%	-64.14%	-105.61%	-45662.68%	-141.44%	-75.57%	-29.05%	663900.00%	-100.01%	-153.67%	2856.09%	-78.24%	125.98%	-34.40%	-149.27%	34.99%	-58.42%
net income margin %	13.77%	-5.33%	-3.96%	29.14%	24.92%	16.72%	14.22%	15.05%	13.66%	3.15%	6.95%	9.41%	8.53%	-0.05%	-1.32%	5.18%	23.26%	-12.87%	-8.93%	2.58%	3.57%	4.89%	164.60%	-6.79%	16.21%	3.31%	11.94%	-9.65%	-14.09%	-1.03%	-3.22%	-4.50%	-11.82%	-14.34%	-3.75%	-11.60%	-5.36%	-26.23%	-15.29%	-141.13%	-35.96%	30.10%	-43.53%	-32.73%	-33.21%	-30.23%	4.21%	-17.47%	-25.15%	-42.21%	-38.74%	-15.74%	-31.12%	-40.18%	-4.18%	-25.81%	-20.55%	-24.79%	-15.56%	-4.59%	-3.99%	-12.00%	222.34%	-0.52%	1.35%	5.41%	8.22%	0.00%	-17.78%	24.68%	1.14%	5.94%	2.79%	5.73%	-20.86%	-13.38%	-40.69%
earnings per share, basic	0.55	-0.24	-0.16	1.25	0.97	0.66	0.56	0.56	0.47	0.11	0.21	0.3	0.27
earnings per share, diluted	0.54	-0.24	-0.16	1.23	0.95	0.65	0.55	0.55	0.46	0.1	0.21	0.29	0.27
weighted-average common shares outstanding, basic	192,497	191,787	192,032	191,907	190,967	190,027	190,429	190,114	188,866	187,834	188,219	187,948	186,667	185,266	185,597	185,254	183,990	182,852	183,214	182,844	181,772	180,804	181,142	180,729	179,898	179,039	179,289		178,271	177,061			175,932	174,427	175,103			165,985	167,714				160,886	160,406	157,612		147,016	146,120	143,983			139,400		120,271			115,070	112,122	112,290	111,114	110,652	103,093	102,110	101,712	101,144	100,271	100,331	100,065	99,902	98,975	99,537	98,923	97,647
weighted-average common shares outstanding, diluted	197,671	197,394	192,032	197,091	196,474	196,708	197,147	200,505	199,262	191,595	191,173	194,998	194,363	188,963	185,597	187,448	194,886	182,852	183,214	185,427	184,365	191,678	197,674	180,729	187,163	179,039	185,924		178,271	177,268			176,150	174,427	175,103			166,219	167,714				161,134	160,406	157,612		159,304	146,351	144,157			139,596		120,271			115,070	112,122	112,290	111,114	110,743	125,674	131,278	101,834	103,720	100,271	101,906	101,217	99,933	103,572	103,403	104,120	103,869
comprehensive income	114,763	74,971	-20,116	176,816	143,184	83,838.5	83,931	135,019	116,404	39,348.5	65,252	48,145	43,997	39,531.75	5,625	47,013	105,489	5,049	-25,316	6,998	38,514	206,805.5	765,138	-33,260	95,344	-1,785	74,600	-39,790				10,624										-60,674.5	-98,203			-12,500.25	16,693			-25,672	-43,988	-20,247
gain on sale of nonfinancial assets									-10,000,000								-108,000,000								-59,495,000
other expense								-4,527,000					-10,830,000				-1,154,000																							-1,417,000		-2,276,250	-281,000
intangible asset amortization and contingent consideration										15,236,000	15,681,000	15,624,000	15,670,000	16,258,000	16,828,000	16,495,000	17,612,000	17,285,000	17,222,000	17,691,000	17,735,000	18,640,000	17,429,000	14,912,000	15,677,000	16,994,000	17,063,000	20,286,000	19,765,000	6,782,000	18,580,000	10,227,000	13,202,000	20,375,000	3,760,000	13,411,000	8,925,000	7,365,000	9,654,000	-54,414,000	10,442,000	-35,208,000	1,301,000	15,470,000	1,431,000	2,171,000	2,934,000	3,668,000	8,957,000	5,441,000	9,639,000	-2,022,000	5,556,000	12,898,000	1,443,000	2,048,000	2,328,000	1,400,000	3,040,000	-3,324,000	312,000	200,000	3,972,000	1,580,000	654,000
net income per share														0.193	-0.04	0.15	0.66	-0.32	-0.2	0.07	0.1	0.12	4.33	-0.16	0.45	0.09	0.31	-0.21	-0.32	-0.02	-0.07	-0.09	-0.25	-0.29	-0.07	-0.21	-0.09	-0.44	-0.26	-2.61	-0.53	0.44	-0.57	-0.51	-0.43	-0.48	0.05	-0.23	-0.26	-0.44	-0.38	-0.15	-0.31	-0.43	-0.04	-0.27	-0.21	-0.24	-0.16	-0.05	-0.04	-0.14	2.13	-0.01	0.01	-0.013	0.07	0.01	-0.13	0.25	0.01	0.04	0.02	0.03	-0.05	-0.04	-0.1
equity in the income of biomarin/genzyme llc																		-337,250	177,000										-185,000				68,000																			-163,000				102,000														-578,000	-572,000	-587,000	-533,000	9,366,000	8,446,000	6,550,000	6,163,000
benefit from income taxes																		-8,676,000	-9,666,000	1,215,000		-62,284,000	-846,019,000			-11,539,500	-45,214,000	-4,460,000		-6,458,250	-6,793,000	-12,385,000	-6,655,000	-6,205,750	-8,094,000	-8,713,000	-8,016,000			-159,385,000	-3,984,000					1,260,250	-4,224,000	5,774,000	3,491,000	2,615,000	704,000	1,242,000	-4,711,000			-411,000	-34,000	3,619,000	-2,078,000	3,904,000	4,764,000	-7,049,000	-221,952,000	1,056,000	636,000	-830,000	945,000	522,000	417,000			153,000	138,000
equity in the loss of biomarin/genzyme llc																				-175,000	-1,351,000	1,071,000	-921,000	-79,000	-77,000	193,000	-551,000	-44,000		-46,000	-468,000	-107,000		-295,000	-253,000	-220,000	-523,000	-164,000	-104,000	-135,000	-135,000	-278,000	-186,000	-204,000	-150,000	225,000	-225,000	-539,000	-338,000	-438,000	-147,000		-401,000	-253,000	-336,000		-734,000	-609,000	-608,000	-667,000	-542,000	-797,000	-639,000	-864,000	-691,000	-443,250	-680,000	-546,000	-547,000
gain on sale of intangible assets																										-10,000,000		-15,000,000		-30,000,000		-20,000,000
weighted-average common shares outstanding, basic and diluted																												179,048			177,481	176,873				174,374	172,710			162,587	161,548	160,025				146,349				137,755	140,796		127,969		123,434	117,912																		95,878	96,199	95,796	94,557
comprehensive loss																													-41,950	-13,043.5	-13,651		-49,147	-24,975	-19,303	-56,511	-24,086	-142,593.5	-45,167	-419,079	-106,128			-93,347	-51,148			-30,836	-35,858				-38,453	-15,972.25	-7,674	-29,868	-26,347
impairment of intangible assets																																						149,779,500		599,118,000
collaborative agreement revenues																																						58,500	1,000		233,000	169,000	131,000	342,000	376,000	318,000	353,000	506,000	415,000	1,140,000	1,754,000	889,000	135,000	226,000	1,210,000	423,000	96,000	93,000	97,000	153,000	125,000	175,000	130,000	176,000	201,000	354,000	648,000	868,000	509,000	31,518,000	2,414,000	2,509,000	2,465,000	17,506,000	3,107,000	3,505,000	4,147,000
royalty, license and other revenues																																						1,083,500	1,633,000	1,555,000	1,146,000	1,347,000	1,006,000	1,158,000	1,576,000	2,784,000	3,078,000	3,037,000	2,133,000
debt conversion expense																																													-163,000			-674,000		-813,000	-1,732,000		-10,420,000						-1,896,000
gain on sale of intangible asset																																															-67,500,000
royalty and license revenues																																																		1,447,000	790,000	3,521,000	449,000	755,000	597,000	605,000	314,000	1,689,000	437,000	862,000	255,000	2,962,000	1,061,000	1,182,000	679,000	2,776,000	1,776,000	447,000	1,557,000	1,802,000	2,420,000	1,207,000	306,000	1,146,000	574,000	4,438,000	357,000
net gain from sale of investments																																																														-25,000			927,000			1,585,000
impairment loss on equity investments																																																																					-5,853,000
amortization of acquired intangible assets																																																																			46,000	1,775,000	1,093,000	1,093,000	1,093,000	1,093,000	1,093,000	1,093,000	1,093,000	1,093,000	1,093,000
net product sales																																																																										26,202,000	21,325,000	20,941,000	18,334,000

Balance Sheets:

Quarterly

Annual

Unit: USD	2026-03-31	2025-12-31	2025-09-30	2025-06-30	2025-03-31	2024-12-31	2024-09-30	2024-06-30	2024-03-31	2023-12-31	2023-09-30	2023-06-30	2023-03-31	2022-12-31	2022-09-30	2022-06-30	2022-03-31	2021-12-31	2021-09-30	2021-06-30	2021-03-31	2020-12-31	2020-09-30	2020-06-30	2020-03-31	2019-12-31	2019-09-30	2019-06-30	2019-03-31	2018-12-31	2018-09-30	2018-06-30	2018-03-31	2017-12-31	2017-09-30	2017-06-30	2017-03-31	2016-12-31	2016-09-30	2016-06-30	2016-03-31	2015-12-31	2015-09-30	2015-06-30	2015-03-31	2014-12-31	2014-09-30	2014-06-30	2014-03-31	2013-12-31	2013-09-30	2013-06-30	2013-03-31	2012-12-31	2012-09-30	2012-06-30	2012-03-31	2011-12-31	2011-09-30	2011-06-30	2011-03-31	2010-12-31	2010-09-30	2010-06-30	2010-03-31	2009-12-31	2009-09-30	2009-06-30	2009-03-31	2008-12-31	2008-09-30	2008-06-30	2008-03-31	2007-12-31	2007-09-30	2007-06-30	2007-03-31	2006-12-31

assets
current assets:
cash and cash equivalents	2,222,435,000	1,311,679,000	1,250,108,000	1,213,816,000	1,048,803,000	942,842,000	675,448,000	972,150,000	746,996,000	755,127,000	785,414,000	694,381,000	580,074,000	724,531,000	761,515,000	619,802,000	605,440,000	587,276,000	617,143,000	641,533,000	667,313,000	649,158,000	1,015,675,000	818,900,000	476,632,000	437,446,000	423,220,000	307,577,000	364,369,000	493,982,000	882,184,000	427,411,000	473,980,000	598,028,000	431,399,000	354,864,000	348,234,000	408,330,000	707,349,000	305,969,000	270,453,000	397,040,000	376,346,000	440,664,000	900,570,000	875,486,000	398,005,000	584,717,000	639,778,000	568,781,000	181,565,000	175,445,000	154,380,000	180,527,000	181,330,000	177,757,000	82,586,000	46,272,000	71,254,000	112,956,000	90,782,000	88,079,000	127,539,000	115,779,000	108,963,000	167,171,000	191,778,000	200,050,000	214,579,000	222,900,000	271,217,000	252,209,000	319,990,000	228,343,000	291,825,000	205,010,000	98,331,000	89,162,000
short-term investments		248,930,000	227,731,000	218,309,000	223,532,000	194,864,000	254,996,000	252,201,000	299,584,000	318,683,000	340,431,000	476,577,000	572,017,000	567,006,000	512,253,000	489,945,000	450,798,000	426,599,000	462,333,000	481,864,000	420,178,000	416,228,000	489,998,000	561,472,000	381,764,000	316,361,000	297,572,000	423,526,000	530,485,000	590,326,000	561,192,000	935,662,000	908,815,000	797,940,000	825,700,000	372,912,000	329,821,000	381,347,000	327,499,000	197,318,000	186,400,000	195,579,000	241,984,000	240,889,000	108,119,000	69,706,000	268,368,000	251,901,000	247,703,000	215,942,000	198,086,000	225,116,000	247,502,000	270,211,000	245,125,000	224,829,000	150,393,000	148,820,000	153,120,000	145,964,000	161,799,000	186,033,000	224,428,000	221,894,000	214,679,000	133,506,000	171,566,000	146,341,000	337,290,000	336,892,000	291,752,000	323,448,000	254,772,000	357,251,000	294,861,000	382,700,000	174,976,000	199,685,000
accounts receivable	903,914,000	908,214,000	790,266,000	855,855,000	739,177,000	660,535,000	777,547,000	691,232,000	637,163,000	633,704,000	572,498,000	610,222,000	597,913,000	461,316,000	419,622,000	466,507,000	430,147,000	373,399,000	374,937,000	424,419,000	396,097,000	448,351,000	411,712,000	381,215,000	396,384,000	377,404,000	402,970,000	377,150,000	393,429,000	342,633,000	384,343,000	363,566,000	318,394,000	261,365,000	251,891,000	238,338,000	230,250,000	215,280,000	215,894,000	214,158,000	180,751,000	164,959,000	148,949,000	186,083,000	175,738,000	144,472,000	121,395,000	122,282,000	110,462,000	117,822,000	124,745,000	115,063,000	120,345,000	109,066,000	117,290,000	100,750,000	105,828,000	104,839,000	107,057,000	106,606,000	106,198,000	86,576,000	78,734,000	77,682,000	82,606,000	73,540,000	68,378,000	72,576,000	61,355,000	54,298,000	51,135,000	52,156,000	47,253,000	16,976,000	15,968,000	15,900,000	14,525,000	14,670,000
inventory	1,273,221,000	1,298,883,000	1,382,173,000	1,340,169,000	1,274,848,000	1,232,653,000	1,179,339,000	1,183,621,000	1,137,982,000	1,107,183,000	1,032,159,000	975,546,000	918,921,000	894,083,000	839,460,000	802,315,000	786,356,000	776,669,000	749,406,000	710,975,000	713,929,000	698,548,000	700,847,000	743,852,000	705,652,000	680,275,000	609,049,000	578,736,000	534,696,000	530,871,000	508,482,000	473,356,000	468,161,000	475,775,000	457,393,000	429,831,000	384,143,000	355,126,000	347,420,000	326,556,000	296,979,000	271,683,000	262,100,000	237,532,000	222,833,000	199,452,000	204,444,000	193,498,000	176,893,000	162,605,000	148,684,000	142,296,000	135,822,000	128,695,000	120,825,000	120,125,000	124,064,000	130,118,000	115,628,000	112,299,000	110,067,000	109,698,000	91,741,000	83,778,000	79,761,000	78,662,000	75,441,000	72,836,000	76,423,000	73,162,000	68,094,000	61,802,000	54,736,000	32,445,000	31,551,000	30,714,000	27,438,000	25,075,000
other current assets	205,500,000	185,784,000	204,265,000	177,183,000	181,545,000	201,533,000	169,260,000	160,426,000	163,287,000	141,391,000	224,806,000	193,391,000	173,180,000	104,521,000	149,851,000	139,029,000	121,283,000	110,442,000	107,751,000	99,046,000	91,249,000	129,934,000	120,747,000	142,127,000	155,817,000	130,657,000	126,548,000	119,779,000	93,876,000	98,403,000	71,652,000	80,072,000	71,760,000	74,036,000	83,646,000	62,875,000	60,340,000	61,708,000	68,409,000	61,945,000	58,207,000	60,378,000	115,330,000	77,558,000	84,265,000	105,310,000	56,458,000	37,268,000	41,013,000	41,707,000	28,161,000	33,526,000	35,501,000	25,509,000	54,816,000	58,073,000	50,519,000	39,753,000	39,965,000	36,286,000	34,984,000	33,874,000	31,747,000	22,775,000	14,422,000	14,848,000	13,104,000	15,178,000	23,928,000	50,270,000	14,609,000	11,951,000	6,654,000	7,195,000	5,076,000	5,306,000	4,561,000	4,036,000
total current assets	4,605,070,000	3,953,490,000	3,854,543,000	3,805,332,000	3,467,905,000	3,232,427,000	3,056,590,000	3,259,630,000	2,985,012,000	2,956,088,000	2,955,308,000	2,950,117,000	2,842,105,000	2,751,457,000	2,682,701,000	2,517,598,000	2,394,024,000	2,274,385,000	2,311,570,000	2,357,837,000	2,288,766,000	2,342,219,000	2,738,979,000	2,647,566,000	2,116,249,000	1,942,143,000	1,859,359,000	1,806,768,000	1,916,855,000	2,056,215,000	2,407,853,000	2,280,067,000	2,241,110,000	2,207,144,000	2,050,029,000	1,458,820,000	1,352,788,000	1,421,791,000	1,666,571,000	1,105,946,000	992,790,000	1,089,639,000	1,175,589,000	1,213,929,000	1,522,728,000	1,425,629,000	1,077,819,000	1,220,227,000	1,246,410,000	1,137,418,000	713,479,000	720,920,000	723,024,000	743,462,000	719,386,000	681,534,000	513,390,000	469,802,000	487,024,000	514,111,000	503,830,000	504,260,000	554,189,000	521,908,000	500,431,000	467,727,000	520,267,000	506,981,000	713,575,000	737,696,000	697,013,000	701,814,000	683,728,000	644,297,000	641,234,000	640,932,000	320,645,000	334,224,000
noncurrent assets:
long-term investments		492,242,000	512,937,000	508,592,000	506,724,000	521,238,000	561,985,000	557,083,000	620,551,000	611,135,000	548,002,000	385,777,000	340,635,000	333,835,000	372,302,000	412,503,000	462,827,000	507,793,000	466,618,000	350,237,000	321,127,000	285,473,000	265,122,000	323,058,000	290,796,000	411,978,000	431,804,000	374,965,000	320,000,000	235,864,000	204,883,000	279,988,000	313,599,000	385,785,000	416,304,000	482,036,000	533,628,000	572,711,000	362,956,000	201,620,000	314,404,000	425,652,000	514,381,000	509,627,000	223,920,000	97,856,000	448,328,000	244,148,000	251,450,000	267,700,000	147,771,000	123,905,000	123,819,000	115,993,000	106,741,000	121,970,000	54,000	94,385,000	145,640,000	153,206,000	141,378,000	128,171,000	88,955,000	117,734,000	128,722,000	169,849,000	128,435,000	138,863,000	4,011,000
property, plant and equipment	958,071,000	952,508,000	1,038,187,000	1,030,385,000	1,032,613,000	1,043,041,000	1,045,408,000	1,052,898,000	1,060,425,000	1,066,133,000	1,067,156,000	1,067,278,000	1,068,142,000	1,073,366,000	1,051,821,000	1,049,464,000	1,039,544,000	1,035,461,000	1,024,787,000	1,026,579,000	1,022,474,000	1,032,471,000	1,015,062,000	1,010,917,000	1,009,972,000	1,010,868,000	969,300,000	962,970,000	951,890,000	948,682,000	924,033,000	900,480,000	895,392,000	896,700,000	878,624,000	851,097,000	824,013,000	798,768,000	729,836,000	724,494,000	716,916,000	704,207,000	604,513,000	568,051,000	538,117,000	523,516,000	486,741,000	469,862,000	437,066,000	319,316,000	285,664,000	282,002,000	281,865,000	284,473,000	273,724,000	267,374,000	264,317,000	268,971,000	266,190,000	216,496,000	217,884,000	221,866,000	213,755,000	212,620,000	203,949,000	199,141,000	182,099,000	159,789,000	142,252,000	124,979,000	110,716,000	105,199,000	95,732,000	76,818,000	66,249,000	58,780,000	56,487,000	55,466,000
intangible assets	204,662,000	213,837,000	233,112,000	239,620,000	247,346,000	255,278,000	260,920,000	265,533,000	279,653,000	294,701,000	302,476,000	310,343,000	325,989,000	338,569,000	354,024,000	369,368,000	374,251,000	388,652,000	388,487,000	394,298,000	405,903,000	417,271,000	427,172,000	433,381,000	443,717,000	456,580,000	462,849,000	476,632,000	485,981,000	491,808,000	494,687,000	502,295,000	509,902,000	517,510,000	530,957,000	538,565,000	546,172,000	553,780,000	561,387,000	568,966,000	1,177,232,000	683,996,000	920,943,000	923,861,000	926,896,000	156,578,000	159,949,000	163,045,000	165,397,000	163,147,000	165,791,000	168,434,000	172,016,000	162,980,000	165,624,000	168,267,000	170,914,000	180,277,000	100,780,000	101,736,000	102,692,000	103,648,000	104,604,000	77,985,000	77,416,000	40,977,000	4,194,000	4,391,000	6,316,000	7,626,000	6,068,000	7,244,000	8,420,000	9,596,000
goodwill	196,199,000	196,199,000	196,199,000	196,199,000	196,199,000	196,199,000	196,199,000	196,199,000	196,199,000	196,199,000	196,199,000	196,199,000	196,199,000	196,199,000	196,199,000	196,199,000	196,199,000	196,199,000	196,199,000	196,199,000	196,199,000	196,199,000	196,199,000	196,199,000	196,199,000	197,039,000	197,039,000	197,039,000	197,039,000	197,039,000	197,039,000	197,039,000	197,039,000	197,039,000	197,039,000	197,039,000	197,039,000	197,039,000	197,039,000	197,039,000	197,039,000	197,039,000	202,392,000	202,392,000	202,392,000	54,258,000	54,258,000	54,258,000	54,258,000	54,258,000	54,258,000	54,975,000	54,975,000	51,543,000	51,543,000	51,543,000	51,543,000	51,543,000	51,543,000	53,055,000	53,055,000	53,364,000	53,364,000	40,360,000	40,360,000	23,722,000	21,262,000	21,262,000	21,262,000	21,262,000	21,262,000	21,262,000	21,262,000	21,262,000	21,262,000	21,262,000	21,262,000	21,262,000
deferred tax assets	1,500,598,000	1,508,697,000	1,509,109,000	1,427,021,000	1,460,566,000	1,489,366,000	1,530,779,000	1,545,006,000	1,546,043,000	1,545,809,000	1,523,953,000	1,509,290,000	1,510,568,000	1,505,412,000	1,455,205,000	1,448,912,000	1,446,676,000	1,449,075,000	1,445,109,000	1,431,683,000	1,429,386,000	1,432,150,000	1,396,547,000	555,137,000	539,990,000	549,422,000	525,131,000	475,554,000	467,333,000	460,952,000	429,194,000	425,380,000	407,009,000	399,095,000	484,759,000	470,961,000	458,387,000	446,786,000	288,006,000	266,182,000	243,212,000	220,191,000
restricted cash equivalents	850,000,000
other assets	276,416,000	277,049,000	270,781,000	249,192,000	235,654,000	251,391,000	199,314,000	190,772,000	184,790,000	171,538,000	165,069,000	144,168,000	150,057,000	176,236,000	151,788,000	151,797,000	149,186,000	151,760,000	144,705,000	141,663,000	141,198,000	142,237,000	119,009,000	135,852,000	125,918,000	122,009,000	112,646,000	99,456,000	96,300,000	36,568,000	37,565,000	39,430,000	32,666,000	29,852,000	22,985,000	21,447,000	26,580,000	32,815,000	36,443,000	23,057,000	25,400,000	408,644,000	60,790,000	58,284,000	80,332,000	65,281,000	61,532,000	46,562,000	41,545,000	156,171,000	14,010,000	14,883,000	15,158,000	16,611,000	19,739,000	20,061,000	19,849,000	15,495,000	13,559,000	12,267,000	12,227,000	14,215,000	228,505,000	14,558,000	14,112,000	15,306,000	12,578,000	12,689,000	12,500,000	12,584,000	12,758,000	13,713,000	13,108,000	15,536,000	14,786,000	14,823,000	6,571,000	9,372,000
total assets	8,591,016,000	7,594,022,000	7,614,868,000	7,456,341,000	7,147,007,000	6,988,940,000	6,851,195,000	7,067,121,000	6,872,673,000	6,841,603,000	6,758,163,000	6,563,172,000	6,433,695,000	6,375,074,000	6,264,040,000	6,145,841,000	6,062,707,000	6,003,325,000	5,977,475,000	5,898,496,000	5,805,053,000	5,848,020,000	6,158,090,000	5,302,110,000	4,722,841,000	4,690,039,000	4,558,128,000	4,393,384,000	4,435,398,000	4,427,128,000	4,695,254,000	4,624,679,000	4,596,717,000	4,633,125,000	4,580,697,000	4,019,965,000	3,938,607,000	4,023,690,000	3,842,238,000	3,087,304,000	3,666,993,000	3,729,368,000	3,624,853,000	3,648,689,000	3,658,686,000	2,490,453,000	2,440,433,000	2,345,685,000	2,340,728,000	2,249,217,000	1,620,530,000	1,601,520,000	1,598,293,000	1,601,643,000	1,567,376,000	1,532,527,000	1,297,085,000	1,303,681,000	1,295,076,000	1,280,392,000	1,264,146,000	1,262,623,000	1,244,533,000	985,516,000	966,205,000	917,163,000	869,357,000	844,437,000	900,283,000	906,695,000	859,038,000	854,555,000	827,702,000	815,279,000	791,056,000	781,639,000	449,764,000	463,436,000
liabilities and stockholders’ equity
current liabilities:
accounts payable and accrued liabilities	793,152,000	759,031,000	798,438,000	684,247,000	628,213,000	606,988,000	715,658,000	572,500,000	593,543,000	683,147,000	669,825,000	597,231,000	598,231,000	572,959,000	492,717,000	434,773,000	426,418,000	491,590,000	466,711,000	411,132,000	399,225,000	492,548,000	480,403,000	443,202,000	454,506,000	570,621,000	483,745,000	429,502,000	412,830,000	437,290,000	378,226,000	358,732,000	346,538,000	401,921,000	364,920,000	319,210,000	272,447,000	370,505,000	306,129,000	292,342,000	290,562,000	392,511,000	296,200,000	256,330,000	230,212,000	235,739,000	206,550,000	166,720,000	156,038,000	183,271,000	167,633,000	142,241,000	144,008,000	147,068,000	111,489,000	96,557,000	96,359,000	94,125,000	83,254,000	82,035,000	75,986,000	83,632,000						59,104,000	55,877,000	58,851,000	47,982,000	54,267,000	42,367,000	49,907,000	35,874,000	30,604,000	24,889,000	32,166,000
total current liabilities	793,152,000	759,031,000	798,438,000	684,247,000	628,213,000	606,988,000	715,658,000	1,067,337,000	1,087,900,000	1,177,024,000	1,163,223,000	597,231,000	598,231,000	588,884,000	521,020,000	464,727,000	490,418,000	539,822,000	514,898,000	443,344,000	430,035,000	492,548,000	854,693,000	813,302,000	820,470,000	932,503,000	493,745,000	439,428,000	500,986,000	523,241,000	838,660,000	804,950,000	773,471,000	816,518,000	417,529,000	374,303,000	340,206,000	439,310,000	377,335,000	364,580,000	388,011,000	445,457,000	390,491,000	347,704,000	305,506,000	235,739,000	206,550,000	166,720,000	156,038,000	183,271,000	167,633,000	142,241,000	144,008,000	170,433,000	134,929,000	119,997,000	119,814,000	94,125,000	83,254,000	82,035,000	75,986,000	83,844,000	92,097,000	83,930,000	78,699,000	78,154,000	64,070,000	60,033,000	126,314,000	130,081,000	120,735,000	63,423,000	53,311,000	61,543,000	49,062,000	44,543,000	38,829,000	46,045,000
noncurrent liabilities:
long-term debt	1,430,282,000
other long-term liabilities	155,475,000	150,816,000	163,056,000	148,819,000	129,685,000	128,824,000	127,514,000	119,369,000	117,352,000	119,935,000	105,457,000	98,120,000	92,415,000	100,015,000	92,473,000	95,260,000	100,913,000	98,519,000	103,131,000	105,711,000	107,728,000	114,195,000	121,237,000	128,711,000	125,172,000	98,124,000	97,432,000	103,686,000	114,558,000	58,647,000	57,370,000	55,080,000	60,953,000	59,105,000	56,780,000	50,979,000	44,484,000	42,034,000	43,273,000	39,312,000	41,935,000	44,588,000	45,853,000	52,038,000	39,980,000	30,077,000	26,260,000	25,658,000	24,720,000	38,549,000	34,411,000	30,756,000	29,539,000	26,674,000	92,392,000	87,239,000	80,449,000	88,179,000	88,944,000	88,532,000	89,799,000	84,001,000	69,689,000	41,541,000	45,183,000	19,741,000	4,351,000	3,887,000	2,946,000	2,856,000	3,162,000	2,108,000	1,769,000	2,082,000	2,854,000	3,278,000	2,479,000	2,078,000
total liabilities	2,378,909,000	1,507,023,000	1,558,157,000	1,429,228,000	1,353,548,000	1,330,950,000	1,437,799,000	1,780,822,000	1,798,857,000	1,890,054,000	1,861,266,000	1,780,345,000	1,774,652,000	1,771,918,000	1,695,526,000	1,641,034,000	1,671,392,000	1,732,585,000	1,711,326,000	1,656,925,000	1,643,043,000	1,742,018,000	2,104,197,000	2,065,431,000	1,482,879,000	1,567,658,000	1,483,723,000	1,432,430,000	1,498,771,000	1,459,188,000	1,780,309,000	1,739,575,000	1,789,714,000	1,824,462,000	1,767,135,000	1,224,386,000	1,169,520,000	1,257,415,000	1,196,430,000	1,169,728,000	1,376,757,000	1,328,521,000	1,332,213,000	1,291,732,000	1,233,231,000	962,559,000	931,991,000	883,716,000	880,607,000	908,176,000	344,000	343,262,000	348,141,000	585,880,000	552,182,000	532,101,000	525,135,000	530,633,000	520,537,000	548,087,000	543,306,000	545,366,000	658,869,000	622,554,000	620,965,000	594,978,000	565,504,000	561,003,000	626,343,000	630,020,000	621,137,000	628,528,000	618,536,000	627,553,000	616,511,000	614,037,000	285,050,000	345,634,000
stockholders’ equity:
common stock	193,000	192,000	192,000	192,000	192,000	191,000	191,000	190,000	190,000	189,000	188,000	188,000	188,000	186,000	186,000	186,000	185,000	184,000	184,000	183,000	183,000	182,000	181,000	181,000	181,000	180,000	180,000	179,000	179,000	178,000	178,000	178,000	177,000	176,000	176,000	175,000	173,000	173,000	173,000	164,000	163,000	162,000	162,000	161,000	161,000	149,000	148,000	147,000	146,000	144,000	142,000	140,000	139,000	126,000	124,000	123,000	116,000	115,000	114,000	112,000	111,000	111,000	103,000	102,000	102,000	101,000	101,000	100,000	100,000	100,000	100,000	99,000	98,000	97,000	97,000	96,000	96,000	92,000
additional paid-in capital	5,966,868,000	5,956,582,000	5,900,968,000	5,851,637,000	5,794,302,000	5,802,068,000	5,739,910,000	5,696,701,000	5,619,264,000	5,611,562,000	5,542,774,000	5,493,956,000	5,417,873,000	5,404,895,000	5,335,853,000	5,272,666,000	5,206,287,000	5,191,502,000	5,133,742,000	5,083,831,000	5,010,619,000	4,993,407,000	4,937,791,000	4,885,637,000	4,854,814,000	4,832,707,000	4,782,916,000	4,744,316,000	4,682,900,000	4,669,926,000	4,620,817,000	4,577,300,000	4,510,451,000	4,483,220,000	4,435,449,000	4,397,980,000	4,314,793,000	4,288,113,000	4,231,514,000	3,458,124,000	3,410,297,000	3,414,837,000	3,371,377,000	3,337,503,000	3,308,137,000	2,359,744,000	2,278,761,000	2,249,445,000	2,213,347,000	2,059,101,000	1,926,133,000	1,863,961,000	1,833,831,000	1,561,890,000	1,505,776,000	1,483,336,000	1,221,933,000	1,197,082,000	1,175,422,000	1,122,732,000	1,103,885,000	1,090,188,000	948,394,000	931,361,000	917,738,000	899,950,000	887,966,000	873,378,000	862,373,000	852,947,000	841,657,000	828,434,000	814,458,000	794,917,000	784,317,000	772,294,000	765,540,000	709,359,000
company common stock held by the nonqualified deferred compensation plan	-10,450,000	-10,508,000	-11,291,000	-11,674,000	-11,177,000	-11,227,000	-11,717,000	-11,673,000	-11,700,000	-9,860,000	-10,393,000	-10,393,000	-9,949,000	-8,859,000	-9,325,000	-9,290,000
accumulated other comprehensive loss	-4,237,000								-1,046,000	-28,788,000		-18,617,000	-10,722,000							-939,000											-2,160,000	-1,129,000	-28,545,000																																										128,000	-7,000	-5,000	-25,000
retained earnings	259,733,000	154,206,000	200,779,000	231,523,000
total stockholders’ equity	6,212,107,000	6,086,999,000	6,056,711,000	6,027,113,000	5,793,459,000	5,657,990,000	5,413,396,000	5,286,299,000	5,073,816,000	4,951,549,000	4,896,897,000	4,782,827,000	4,659,043,000	4,603,156,000	4,568,514,000	4,504,807,000	4,391,315,000	4,270,740,000	4,266,149,000	4,241,571,000	4,162,010,000	4,106,002,000	4,053,893,000	3,236,679,000	3,239,962,000	3,122,381,000	3,074,405,000	2,960,954,000	2,936,627,000	2,967,940,000	2,914,945,000	2,885,104,000	2,807,003,000	2,808,663,000	2,813,562,000	2,795,579,000	2,769,087,000	2,766,275,000	2,645,808,000	1,917,576,000	2,290,236,000	2,400,847,000	2,292,640,000	2,356,957,000	2,425,455,000	1,527,894,000	1,508,442,000	1,461,969,000	1,460,121,000	1,341,041,000	1,276,486,000	1,258,258,000	1,250,152,000	1,015,763,000	1,015,194,000	1,000,426,000	771,950,000	773,048,000	774,539,000	732,305,000	720,840,000	717,257,000	585,664,000	362,962,000	345,240,000	322,185,000	303,853,000	283,434,000	273,940,000	276,675,000	237,901,000	226,027,000	209,166,000	187,726,000	174,545,000	167,602,000	164,714,000	117,802,000
total liabilities and stockholders’ equity	8,591,016,000	7,594,022,000	7,614,868,000	7,456,341,000	7,147,007,000	6,988,940,000	6,851,195,000	7,067,121,000	6,872,673,000	6,841,603,000	6,758,163,000	6,563,172,000	6,433,695,000	6,375,074,000	6,264,040,000	6,145,841,000	6,062,707,000	6,003,325,000	5,977,475,000	5,898,496,000	5,805,053,000	5,848,020,000	6,158,090,000	5,302,110,000	4,722,841,000	4,690,039,000	4,558,128,000	4,393,384,000	4,435,398,000	4,427,128,000	4,695,254,000	4,624,679,000	4,596,717,000	4,633,125,000	4,580,697,000	4,019,965,000	3,938,607,000	4,023,690,000	3,842,238,000	3,087,304,000	3,666,993,000	3,729,368,000	3,624,853,000	3,648,689,000	3,658,686,000	2,490,453,000	2,440,433,000	2,345,685,000	2,340,728,000	2,249,217,000	1,620,530,000	1,601,520,000	1,598,293,000	1,601,643,000	1,567,376,000	1,532,527,000	1,297,085,000	1,303,681,000	1,295,076,000	1,280,392,000	1,264,146,000	1,262,623,000	1,244,533,000	985,516,000	966,205,000	917,163,000	869,357,000	844,437,000	900,283,000	906,695,000	859,038,000	854,555,000	827,702,000	815,279,000	791,056,000	781,639,000	449,764,000	463,436,000
long-term convertible debt		597,176,000	596,663,000	596,162,000	595,650,000	595,138,000	594,627,000	594,116,000	593,605,000	593,095,000	592,586,000	1,084,994,000	1,084,006,000	1,083,019,000	1,082,033,000	1,081,047,000	1,080,061,000	1,079,077,000	1,078,093,000	1,077,110,000	1,076,127,000	1,075,145,000	1,074,164,000	1,073,202,000	486,713,000	486,238,000	843,616,000	839,165,000	834,766,000	830,417,000	826,119,000	821,871,000	817,672,000	813,521,000	1,166,036,000	676,205,000	668,437,000	660,761,000	653,178,000	645,685,000	668,009,000	662,286,000	667,793,000	661,492,000	655,491,000	657,976,000	656,884,000	650,872,000	661,419,000	655,566,000	78,310,000	109,822,000	109,849,000	324,859,000	324,861,000	324,865,000	324,872,000
accumulated other comprehensive income		-13,473,000	-33,937,000	-44,565,000	19,151,000	61,653,000	4,650,000	26,799,000			6,257,000			-3,867,000	30,749,000	18,472,000	-877,000	14,432,000	10,239,000		5,004,000	-16,139,000	10,385,000	30,050,000	34,127,000	20,164,000	37,003,000	17,439,000	19,794,000	5,271,000				-22,961,000	-21,434,000	-14,658,000	5,020,000	12,816,000	2,158,000	4,528,000	47,000	21,033,000	25,184,000	32,461,000	43,819,000	27,466,000	19,189,000	9,941,000	7,275,000	5,018,000	11,473,000	2,441,000	1,155,000	-202,000	2,333,000	4,650,000	2,512,000	4,887,000	1,304,000	-5,923,000	-5,787,000	188,000	-1,581,000	10,224,000	4,405,000	933,000	-704,000	101,000	2,069,000	1,106,000	-1,818,000	-575,000	351,000	139,000
accumulated deficit					-9,009,000	-194,695,000	-319,638,000	-425,718,000	-532,892,000	-621,554,000	-641,929,000	-682,307,000	-738,347,000	-789,199,000	-788,949,000	-777,227,000	-804,891,000	-925,689,000	-867,791,000	-831,297,000	-844,238,000	-861,609,000	-883,708,000	-1,668,511,000	-1,639,328,000	-1,720,709,000	-1,735,733,000	-1,790,769,000	-1,753,334,000	-1,694,134,000	-1,690,475,000	-1,677,855,000	-1,661,063,000	-1,637,548,000	-1,586,156,000	-1,573,629,000	-1,536,796,000	-1,520,506,000	-1,573,068,000	-1,530,271,000	-1,106,711,000	-1,021,569,000	-1,090,186,000	-999,260,000	-917,271,000	-849,770,000	-779,973,000	-787,418,000	-753,916,000	-715,801,000	-653,811,000	-600,791,000	-579,258,000	-539,448,000	-486,436,000	-481,079,000	-449,073,000	-425,101,000	-398,366,000	-380,713,000	-375,636,000	-371,265,000	-359,076,000	-576,410,000	-575,933,000	-577,084,000	-581,795,000	-588,436,000	-589,748,000	-576,596,000	-601,102,000	-601,931,000	-605,741,000	-607,427,000	-609,997,000	-604,781,000	-600,917,000	-591,624,000
short-term convertible debt								494,837,000	494,357,000	493,877,000	493,398,000												374,290,000	370,100,000	365,964,000	361,882,000					374,230,000	369,752,000	365,326,000	360,949,000			22,495,000	22,478,000	22,460,000	24,420,000
short-term contingent consideration														15,925,000	28,303,000	29,954,000	64,000,000	48,232,000	48,187,000	32,212,000	30,810,000						10,000,000	9,926,000	88,156,000	85,951,000
long-term contingent consideration																		15,167,000	15,204,000	30,760,000	29,153,000	60,130,000	54,103,000	50,216,000	50,524,000	50,793,000	48,930,000	50,151,000	48,461,000	46,883,000
company common stock held by nonqualified deferred compensation plan																	-9,389,000	-9,689,000	-10,225,000	-10,207,000	-9,558,000	-9,839,000	-10,756,000	-10,678,000	-9,832,000	-9,961,000	-9,961,000	-10,211,000	-12,912,000	-13,301,000	-13,415,000	-13,390,000	-14,017,000	-14,224,000	-14,473,000	-14,289,000	-14,103,000	-14,321,000	-14,969,000	-14,969,000	-13,560,000	-13,616,000	-13,897,000	-13,908,000	-9,391,000	-9,695,000	-9,683,000	-10,146,000	-6,731,000	-7,421,000	-7,451,000	-7,493,000	-5,715,000	-6,603,000	-6,603,000	-6,604,000	-3,538,000	-3,935,000	-3,935,000	-3,903,000	-1,733,000	-1,965,000	-2,176,000	-2,315,000	-1,072,000
short-term contingent acquisition consideration																															86,204,000	76,466,000
long-term contingent acquisition consideration																															58,160,000	57,674,000
short-term contingent acquisition consideration payable																																	61,607,000	53,648,000	52,609,000	55,093,000	45,264,000	46,327,000	48,746,000	47,818,000	97,449,000	52,946,000	94,291,000	91,374,000	75,294,000
long-term contingent acquisition consideration payable																																	137,618,000	135,318,000	126,790,000	122,899,000	116,393,000	115,310,000	122,644,000	120,151,000	135,275,000	32,663,000	34,874,000	37,296,000	39,052,000	38,767,000	42,297,000	40,466,000	38,430,000	30,790,000	26,500,000	23,261,000	27,224,000	30,618,000
deferred tax liabilities																																									143,527,000
long-term deferred tax liabilities																																										143,527,000	193,202,000	193,202,000	193,202,000						37,190,000	37,182,000	37,521,000	33,296,000
current deferred tax assets																																											30,880,000	31,203,000	31,203,000	31,203,000	29,149,000	30,561,000	30,561,000	30,561,000	32,238,000	29,474,000	29,474,000	29,454,000
long-term deferred tax assets																																											146,245,000	172,545,000	163,411,000	166,296,000	150,991,000	147,143,000	144,124,000	150,391,000	238,703,000	235,400,000	226,757,000	225,501,000	229,771,000	220,593,000	221,239,000	222,649,000	229,172,000	228,400,000	231,947,000	236,017,000
investment in biomarin/genzyme llc																																													890,000	1,039,000	815,000	440,000	478,000	816,000	854,000	1,001,000	679,000	1,080,000	848,000	1,185,000	1,082,000	559,000	1,168,000	1,121,000	1,133,000	1,082,000	1,161,000	351,000	1,215,000	441,000	522,000	462,000	367,000	915,000	343,000	315,000	905,000	44,881,000	35,516,000	33,269,000	31,619,000	31,457,000
convertible debt																																																						23,365,000	23,440,000	23,440,000	23,455,000	348,329,000	348,339,000	377,520,000	377,521,000	377,521,000	497,083,000	497,083,000	497,083,000	497,083,000	497,083,000	497,083,000	497,083,000	497,083,000	497,240,000	497,245,000	497,300,000	497,375,000	497,375,000	497,375,000	172,500,000	223,940,000
deferred revenue																																																														212,000			158,000	86,000	149,000	929,000	120,000	307,000	1,443,000	3,236,000	4,879,000
accounts payable, accrued liabilities and other current liabilities																																																															92,097,000	83,930,000	78,541,000	78,068,000	63,921,000
acquisition obligation, net of discount																																																																					70,317,000
company common stock held by deferred compensation plan																																																																		-1,715,000	-1,715,000	-1,709,000	-854,000	-882,000	-936,000
advances to biomarin/genzyme llc																																																																						174,000	206,000	248,000	323,000	2,087,000	1,953,000	1,302,000	814,000	1,596,000
other investments																																																																						1,633,000	4,659,000
current portion of acquisition obligation, net of discount																																																																						70,741,000	71,158,000	5,816,000	6,065,000	6,309,000	6,549,000	6,785,000	6,786,000	6,787,000
other current liabilities																																																																						182,000	152,000	104,000
long-term portion of acquisition obligation, net of discount																																																																								65,752,000	66,156,000	66,553,000	66,946,000	67,332,000	67,945,000	68,548,000
restricted cash																																																																							6,219,000	5,008,000	4,547,000	2,889,000	3,632,000	3,103,000	2,617,000
current portion of deferred revenue																																																																										5,327,000	6,639,000	7,154,000	7,154,000	7,092,000
deferred revenue, net of current portion																																																																											274,000	1,509,000	3,297,000	5,023,000
acquired intangible assets																																																																											8,377,000	9,470,000	10,563,000	11,655,000
cash balances related to long-term debt
current portion of equipment and facility loans
equipment and facility loan, net of current portion
stockholders’ equity

Cashflow Statements:

Quarterly

Annual

Unit: USD	2026-03-31	2025-12-31	2025-09-30	2025-06-30	2025-03-31	2024-12-31	2024-09-30	2024-06-30	2024-03-31	2023-12-31	2023-09-30	2023-06-30	2023-03-31	2022-12-31	2022-09-30	2022-06-30	2022-03-31	2021-12-31	2021-09-30	2021-06-30	2021-03-31	2020-12-31	2020-09-30	2020-06-30	2020-03-31	2019-12-31	2019-09-30	2019-06-30	2019-03-31	2018-09-30	2018-06-30	2018-03-31	2017-09-30	2017-06-30	2017-03-31	2016-09-30	2016-06-30	2016-03-31	2015-09-30	2015-06-30	2015-03-31	2013-12-31	2013-09-30	2012-12-31	2012-09-30	2011-12-31	2011-09-30	2010-12-31	2010-09-30	2010-06-30	2010-03-31	2009-12-31	2009-09-30	2009-06-30	2009-03-31	2008-12-31	2008-09-30	2008-06-30	2008-03-31	2007-12-31	2007-09-30	2007-06-30	2007-03-31

cash flows from operating activities:
net income	105,527,000	-46,573,000	-30,744,000	240,532,000	185,686,000	124,943,000	106,080,000	107,174,000	88,662,000	20,375,000	40,378,000	56,040,000	50,852,000	-249,000	-6,652,000	27,664,000	120,798,000	-57,898,000	-36,494,000	12,941,000	17,371,000	22,099,000	784,803,000	-29,183,000	81,381,000																	-61,990,000	-53,020,000			-26,735,000	-17,653,000	-12,189,000	217,334,000	-477,000	1,151,000	4,711,000	6,641,000	1,312,000	-13,152,000	24,506,000	829,000	3,810,000	1,686,000	2,570,000	-5,216,000	-3,864,000	-9,293,000
adjustments to reconcile net income to net cash from operating activities:
depreciation and amortization	16,411,000	20,438,000	18,487,000	18,563,000	22,069,000	23,607,000	19,006,000	26,463,000	27,350,000	26,861,000	25,685,000	25,419,000	26,421,000	24,553,000	24,802,000	25,271,000	27,343,000	25,986,000	26,839,000	27,231,000	27,983,000	27,358,000	26,634,000	25,216,000	25,964,000	25,790,000	30,739,000	26,344,000	22,427,000	70,955,000	44,610,000	23,633,000	59,197,000	38,497,000	19,412,000	76,805,000	48,496,000	20,244,000	45,306,000	29,579,000	14,397,000	9,384,000	13,375,000	11,857,000	11,667,000	9,628,000	9,350,000	7,931,000	7,819,000	6,577,000	5,410,000	4,861,000	4,841,000	6,170,000	5,103,000	4,757,000	4,554,000	4,450,000	3,870,000	3,705,000	3,489,000	3,313,000	3,036,000
non-cash interest expense	6,086,000	653,000	649,000	660,000	660,000	660,000	718,000	991,000	990,000	990,000	1,140,000	1,029,000	1,029,000	1,028,000	1,027,000	1,029,000	1,033,000	1,032,000	1,032,000	1,039,000	1,043,000	1,745,000	5,232,000	4,916,000	4,618,000	4,565,000	525,000	4,461,000	4,409,000	26,099,000	17,300,000	8,601,000	23,792,000	15,601,000	7,755,000	22,276,000	14,762,000	7,337,000	21,243,000	14,080,000	7,000,000
accretion of discount on investments	-455,000	-1,106,000	-978,000	-1,355,000	-1,362,000		-1,941,000	-2,176,000	-2,502,000																			-619,000	-891,000	769,000	-41,000	761,000	2,162,000	1,327,000	660,000	681,000	536,000	309,000	1,616,000	941,000	417,000	1,631,000	1,320,000
stock-based compensation	43,458,000	46,913,000	49,265,000	47,531,000	37,700,000	51,919,000	43,489,000	47,914,000	58,249,000	54,855,000	48,387,000	50,162,000	53,695,000	46,734,000	54,663,000	47,078,000	47,833,000		49,026,000	54,843,000	49,503,000		50,169,000	44,962,000	46,994,000		39,173,000	39,829,000	42,761,000	112,261,000	75,214,000	36,608,000	106,678,000	70,775,000	30,674,000	97,220,000	64,075,000	30,177,000	84,465,000	54,396,000	23,714,000	23,543,000	16,790,000	11,926,000	11,990,000	11,188,000	11,784,000	9,835,000	10,294,000	9,627,000	8,606,000	9,356,000	9,155,000	8,960,000	8,534,000	8,228,000	8,243,000	6,655,000	5,210,000	5,544,000
impairment of assets				0	2,967,000																															599,118,000	599,118,000		12,802,000	12,802,000
deferred income taxes	9,220,000	613,000	-13,646,000	33,342,000	28,429,000	42,387,000	12,172,000	1,252,000	285,000	-24,844,000	-15,029,000	1,252,000	-6,360,000	-51,344,000	-4,198,000	-1,345,000	4,800,000	-3,588,000	-13,224,000	-2,131,000	3,335,000	-34,708,000	-848,335,000	-16,467,000	10,603,000	-22,980,000	-49,697,000	-9,379,000	-704,000	-32,735,000	-29,681,000	-13,988,000	-36,150,000	-22,770,000	-10,441,000	-206,691,000	-184,494,000	-19,277,000	14,629,000	-14,951,000	-7,800,000	10,056,000	-9,490,000	689,000	-10,753,000	-2,481,000	-149,000	-7,512,000
unrealized foreign exchange losses	6,710,000
other	-5,374,000	-2,710,000	212,000	-649,000	-1,267,000	21,389,000	-396,000	-985,000	127,000	-141,000	-585,000	583,000	-222,000	-1,343,000	-682,000	-718,000	700,000	-1,312,000	-941,000	495,000	-871,000	-1,385,000	1,038,000	-267,000	-383,000	-1,661,000	3,585,000	-3,584,000	-19,000	-459,000	1,772,000	662,000	4,657,000	3,806,000	969,000	1,044,000	705,000	526,000	1,059,000	721,000	-443,000															-164,000
changes in operating assets and liabilities:
accounts receivable	-7,159,000	-120,676,000	48,746,000	-98,534,000	-57,590,000	72,547,000	-74,375,000	-52,695,000	-3,386,000	-58,495,000	13,891,000	-7,035,000	-138,796,000	-28,281,000	38,810,000	-37,749,000	-54,813,000	61,000	48,093,000	-22,874,000	40,294,000	-26,120,000	-24,887,000	23,870,000	-31,898,000	23,951,000	-30,773,000	20,660,000	-51,690,000	-95,884,000	-77,416,000	-26,257,000	-21,598,000	-16,834,000	-14,051,000	-52,023,000	-50,250,000	-16,044,000	146,000	-37,587,000	-26,789,000	6,923,000	-9,682,000	8,224,000	-16,540,000	2,025,000	-451,000	-7,842,000	-1,052,000	4,924,000	-9,066,000	-5,162,000	4,198,000	-11,221,000	-7,057,000	-3,163,000	1,021,000	-4,903,000	-30,277,000	-1,008,000	-67,000	-1,376,000	145,000
inventory	44,490,000	-18,133,000	-26,334,000	-48,127,000	-24,335,000	-34,271,000	18,150,000	-30,589,000	-16,820,000	-59,110,000	-41,472,000	-42,378,000	-14,098,000	-40,845,000	-25,988,000	-2,556,000	1,125,000	-15,935,000	-25,504,000	12,804,000	-6,425,000	12,159,000	-27,012,000	-25,592,000	-20,706,000	-54,983,000	-19,452,000	-34,854,000	1,735,000	-10,232,000	15,493,000	10,843,000	-80,885,000	-60,369,000	-22,660,000	-59,802,000	-42,713,000	-11,803,000	-61,980,000	-38,434,000	-23,946,000	-13,921,000	-6,388,000	-7,870,000	-700,000	-14,490,000	-3,329,000	-17,957,000	-7,963,000	-4,017,000	-1,099,000	-3,221,000	-2,605,000	3,586,000	-3,260,000	-5,069,000	-6,293,000	-7,050,000	4,474,000	-895,000	-837,000	-3,276,000	-2,363,000
other current assets	-11,551,000	41,016,000	-17,033,000	-8,765,000	-6,327,000	16,161,000	-21,554,000	18,968,000	-17,353,000	9,054,000	-5,959,000	-17,429,000	-36,001,000	16,380,000	3,443,000	-3,990,000	-8,011,000	2,731,000	-7,302,000	-8,453,000	42,784,000	-14,536,000	12,407,000	12,139,000	8,302,000	-13,749,000	-8,270,000	-15,101,000	10,112,000	4,276,000	-2,037,000	2,924,000	-20,787,000	-3,710,000	2,763,000	-1,556,000	3,186,000	2,399,000	-27,970,000	2,211,000	-3,522,000	-10,297,000	4,583,000	4,648,000	6,022,000	8,690,000	-2,889,000	2,593,000	-641,000	-1,638,000	2,925,000	3,658,000	1,964,000	6,074,000	25,719,000	-36,428,000	-1,872,000	-5,297,000	541,000	-2,118,000	228,000	-825,000	-443,000
other assets	1,484,000	-5,894,000	-19,174,000	-11,881,000	-1,624,000	-41,861,000	-8,959,000	-10,750,000	-12,130,000	-10,337,000	-15,196,000	-5,293,000	-323,000	-31,999,000	2,991,000	7,709,000	1,440,000	-6,186,000	-728,000	-1,296,000	1,617,000	-23,104,000	56,000	-5,158,000	-441,000	-1,783,000	-2,519,000	-6,813,000	2,220,000	-3,148,000	-6,448,000	-1,099,000	-1,030,000	-1,109,000	-527,000	-5,002,000	-1,439,000	-1,232,000	-1,391,000	497,000	330,000	1,983,000	78,000	2,829,000	-670,000	-947,000	-1,639,000	-3,178,000	498,000	-1,775,000	-871,000	695,000	-307,000	-1,453,000	-221,000	2,329,000	-665,000	-1,478,000	-143,000	-2,746,000	-903,000	-572,000	-524,000
accounts payable and accrued liabilities	3,100,000	-53,342,000	116,367,000	5,766,000	-2,655,000												-78,143,000	22,818,000	53,755,000	11,420,000	-72,304,000	-10,851,000	18,251,000	308,000	-94,733,000	55,342,000	59,318,000	4,499,000	-42,070,000	-12,090,000	-32,989,000	-51,887,000	-1,732,000	-36,286,000	-77,822,000	-77,852,000	-87,560,000	-90,744,000	924,000	-33,633,000	-57,236,000	9,058,000	19,057,000	21,586,000	14,393,000	8,650,000	4,146,000						2,803,000	1,863,000	-4,046,000	6,486,000	-3,495,000	12,123,000	-7,681,000	11,197,000	1,990,000	5,278,000	-6,817,000
other long-term liabilities	8,704,000	-7,023,000	16,355,000	3,468,000	2,069,000	4,532,000	3,520,000	3,400,000	3,309,000	9,252,000	7,229,000	2,842,000	4,262,000	10,185,000	-1,676,000	-3,286,000	1,710,000	-3,605,000	-316,000	-1,719,000	2,304,000	-16,096,000	3,287,000	794,000	5,144,000	742,000	-7,893,000	8,805,000	1,474,000	3,744,000	2,663,000	-408,000	3,497,000	3,459,000	2,744,000	-4,451,000	-8,058,000	-4,614,000	790,000	7,070,000	9,186,000	4,191,000	3,351,000	-2,591,000	4,390,000	943,000	450,000	860,000	693,000	-702,000	1,049,000
net cash from operating activities	220,651,000	99,644,000	368,685,000	185,271,000	174,394,000	185,627,000	221,481,000	118,762,000	46,971,000	27,483,000	135,646,000	70,062,000	-73,932,000	6,786,000	158,321,000	56,226,000	-45,431,000	11,180,000	97,060,000	82,784,000	113,512,000	-13,384,000	86,206,000	27,737,000	-15,194,000	57,343,000	70,125,000	-24,338,000	-54,868,000	-29,166,000	-76,366,000	-42,509,000	-23,371,000	-61,663,000	-80,443,000	-228,190,000	-217,573,000	-171,553,000	-153,652,000	-150,802,000	-137,811,000	-11,296,000	-9,492,000	11,986,000	14,214,000	-175,000	8,861,000	-15,782,000	9,057,000	22,221,000	3,250,000	19,466,000	29,075,000	19,171,000	20,020,000	3,967,000	1,885,000	7,193,000	-22,220,000	2,064,000	-9,733,000	-6,700,000	-20,126,000
capital expenditures	-20,923,000	-40,722,000	-28,447,000	-17,101,000	-16,768,000	-19,530,000	-18,463,000	-21,327,000	-26,104,000	-28,917,000	-21,735,000	-21,583,000	-24,456,000	-35,688,000	-29,300,000	-27,154,000	-28,817,000	-28,738,000	-18,734,000	-22,599,000	-25,507,000	-31,026,000	-16,570,000	-26,162,000	-40,554,000	-50,785,000	-32,854,000	-32,631,000	-28,756,000	-102,541,000	-52,682,000	-30,164,000	-159,329,000	-116,847,000	-69,090,000	-96,806,000	-70,710,000	-45,204,000	-123,844,000	-79,288,000	-43,832,000	-29,684,000	-13,202,000	-13,895,000	-15,013,000	-8,680,000	-56,388,000	0	-9,372,000	-15,240,000	-14,108,000	0	-26,559,000	-21,884,000	-18,737,000	-11,923,000	-12,113,000	0	-19,889,000	0	-5,648,000	0	-3,235,000
free cash flows	199,728,000	58,922,000	340,238,000	168,170,000	157,626,000	166,097,000	203,018,000	97,435,000	20,867,000	-1,434,000	113,911,000	48,479,000	-98,388,000	-28,902,000	129,021,000	29,072,000	-74,248,000	-17,558,000	78,326,000	60,185,000	88,005,000	-44,410,000	69,636,000	1,575,000	-55,748,000	6,558,000	37,271,000	-56,969,000	-83,624,000	-131,707,000	-129,048,000	-72,673,000	-182,700,000	-178,510,000	-149,533,000	-324,996,000	-288,283,000	-216,757,000	-277,496,000	-230,090,000	-181,643,000	-40,980,000	-22,694,000	-1,909,000	-799,000	-8,855,000	-47,527,000	-15,782,000	-315,000	6,981,000	-10,858,000	19,466,000	2,516,000	-2,713,000	1,283,000	-7,956,000	-10,228,000	7,193,000	-42,109,000	2,064,000	-15,381,000	-6,700,000	-23,361,000
cash flows from investing activities:
purchases of property, plant and equipment	-20,923,000	-40,722,000	-28,447,000	-17,101,000	-16,768,000	-19,530,000	-18,463,000	-21,327,000	-26,104,000	-28,917,000	-21,735,000	-21,583,000	-24,456,000	-35,688,000	-29,300,000	-27,154,000	-28,817,000	-28,738,000	-18,734,000	-22,599,000	-25,507,000	-31,026,000	-16,570,000	-26,162,000	-40,554,000	-50,785,000	-32,854,000	-32,631,000	-28,756,000	-102,541,000	-52,682,000	-30,164,000	-159,329,000	-116,847,000	-69,090,000	-96,806,000	-70,710,000	-45,204,000	-123,844,000	-79,288,000	-43,832,000	-29,684,000	-13,202,000	-13,895,000	-15,013,000	-8,680,000	-56,388,000
maturities and sales of investments	767,277,000	43,254,000	98,809,000	117,934,000	77,804,000	154,582,000	160,787,000	186,116,000	131,533,000	113,186,000	260,614,000	275,945,000	215,118,000	142,751,000	165,646,000	155,780,000	155,818,000	188,937,000	153,171,000	154,304,000	194,637,000	210,610,000	175,113,000	75,410,000	94,701,000	104,533,000	212,201,000	203,583,000	219,894,000	857,063,000	311,969,000	104,462,000	325,678,000	234,617,000	149,916,000	302,801,000	283,780,000	181,267,000	261,786,000	154,200,000	124,137,000	56,018,000	77,526,000	72,378,000	58,412,000	54,897,000	81,455,000	70,622,000	85,057,000	28,627,000	22,055,000	102,250,000	46,359,000
purchases of investments	-25,792,000	-42,613,000	-110,829,000	-113,159,000	-89,274,000	-57,879,000	-156,909,000	-73,797,000	-121,665,000	-141,453,000	-282,994,000	-223,685,000	-220,364,000	-154,427,000	-152,577,000
net cash from investing activities	725,528,000	-42,449,000	-330,963,000	-12,592,000	-28,238,000	76,404,000	-16,157,000	90,480,000	-14,236,000	-64,963,000	-45,799,000	29,530,000	-30,012,000	-54,710,000	-23,402,000	-29,699,000	87,782,000	-55,421,000	-119,847,000	-120,257,000	-70,788,000	11,027,000	106,699,000	-248,751,000	77,404,000	-48,896,000	48,678,000	19,671,000	-50,479,000	335,314,000	-67,012,000	-71,734,000	-445,005,000	-14,776,000	25,047,000	-174,398,000	152,539,000	76,999,000	-1,259,149,000	-1,196,069,000	-750,871,000	-306,416,000	3,313,000	-52,353,000	-20,947,000	-34,914,000	-58,321,000	-13,610,000	-4,005,000	-13,129,000	-70,598,000	-45,521,000	-42,867,000	36,401,000	-27,688,000	-54,698,000	14,751,000	-80,492,000	101,362,000	-68,851,000	91,539,000	-203,288,000	29,604,000
cash flows from financing activities:
taxes paid related to net share settlement of equity awards	-28,180,000	-2,700,000	-2,176,000	-12,310,000	-38,779,000	-4,909,000	-5,912,000	-16,791,000	-49,948,000	-3,920,000	-4,537,000	-16,440,000	-51,422,000	-3,587,000	-6,319,000	-11,428,000	-32,949,000	-1,377,000	-5,697,000	-9,634,000	-29,097,000	-1,971,000	-6,022,000	-7,801,000	-28,844,000	-1,729,000	-4,051,000	-6,795,000	-30,105,000	-34,180,000	-28,614,000	-22,899,000	-31,863,000	-26,624,000	-17,935,000	-55,241,000	-52,824,000	-40,788,000	-21,968,000	-19,566,000	-735,000
proceeds from issuance of debt	850,000,000
payments of debt issuance costs	-8,653,000
net cash from financing activities	813,167,000	3,157,000	-2,169,000	-4,603,000	-38,779,000	2,859,000	-499,125,000	12,612,000	-42,793,000	10,840,000	-788,000	11,963,000	-40,742,000	10,869,000	7,541,000	-11,780,000	-25,280,000	14,396,000	-1,031,000	10,951,000	-24,364,000	-366,155,000	3,256,000	563,688,000	-19,671,000	4,042,000	-1,975,000	-51,760,000	-24,981,000	-21,645,000	-26,796,000	-9,765,000	494,049,000	12,113,000	-6,743,000	707,758,000	-29,496,000	-37,165,000	916,205,000	912,440,000	914,791,000	704,928,000	12,299,000	39,564,000	10,306,000	10,107,000	7,758,000	-10,068,000	6,708,000	-2,276,000	9,140,000	1,448,000	5,521,000	-70,102,000	-653,000	2,414,000	2,372,000	5,518,000	12,505,000	3,306,000	4,908,000	316,666,000	-310,000
effect of exchange rate changes on cash	1,410,000	1,219,000	739,000	-3,063,000	-1,416,000	2,504,000	-2,901,000	3,300,000	1,927,000	-3,647,000	1,974,000	2,752,000	229,000	71,000	-747,000	-385,000	1,093,000	-22,000	-572,000	742,000	-205,000	1,995,000	614,000	-406,000	-3,353,000	1,737,000	-1,185,000	-365,000	715,000	-347,000	-443,000	-40,000	-2,604,000	10,860,000	2,043,000	5,139,000	3,459,000	5,132,000	-2,544,000	-391,000	-1,025,000
net increase in cash, cash equivalents and restricted cash equivalents	1,760,756,000
cash, cash equivalents and restricted cash equivalents:
beginning of period	1,311,679,000	0	0	0	942,842,000	0	0	0	755,127,000	0	0	0	724,531,000	0	0	0	587,276,000	0	0	0	649,158,000	0	0	0	437,446,000	0	0	0	493,982,000	598,028,000	598,028,000	598,028,000	408,330,000	408,330,000	408,330,000	397,040,000	397,040,000	397,040,000	875,486,000	875,486,000	875,486,000	0	0	0	0	0	0		0	0	167,171,000		0	0	222,900,000		0	0	228,343,000		0	0	89,162,000
end of period	3,072,435,000	61,571,000	36,292,000	165,013,000	1,048,803,000	267,394,000	-296,702,000	225,154,000	746,996,000	-30,287,000	91,033,000	114,307,000	580,074,000	-36,984,000	141,713,000	14,362,000	605,440,000	-29,867,000	-24,390,000	-25,780,000	667,313,000	-366,517,000	196,775,000	342,268,000	476,632,000	14,226,000	115,643,000	-56,792,000	364,369,000	882,184,000	427,411,000	473,980,000	431,399,000	354,864,000	348,234,000	707,349,000	305,969,000	270,453,000	376,346,000	440,664,000	900,570,000	387,216,000	6,120,000	-803,000	3,573,000	-24,982,000	-41,702,000		11,760,000	6,816,000	108,963,000		-8,272,000	-14,529,000	214,579,000		19,008,000	-67,781,000	319,990,000		86,815,000	106,679,000	98,331,000
supplemental cash flow disclosures:
cash paid for income taxes	14,644,000	25,997,000	7,823,000	51,997,000	10,388,000	21,181,000	13,204,000	20,583,000	2,301,000	21,625,000	23,504,000	23,819,000	4,364,000	40,947,000	1,604,000	10,505,000	1,316,000	2,622,000	5,372,000	7,161,000	2,998,000	4,622,000	1,395,000	693,000	2,267,000	3,638,000	2,155,000	3,027,000	906,000	15,791,000	14,858,000	11,731,000	21,744,000	16,341,000	6,376,000	95,163,000	93,969,000	73,215,000	15,377,000	13,814,000	1,358,000	1,732,000	1,777,000	991,000	677,000	1,009,000	1,088,000	677,000	1,721,000	929,000	254,000	1,758,000	253,000	406,000	407,000	1,029,000	145,000
supplemental cash flow disclosures for non-cash investing and financing activities:
accounts payable and accrued liabilities related to fixed assets	11,200,000
accounts payable and accrued liabilities related to intangible assets	4,481,000
gain on sale of nonfinancial assets						0	0	0	-10,000,000					0	0	0	-108,000,000					0	0	0	-59,495,000
roctavian inventory write-off
unrealized foreign exchange gain		4,215,000	5,550,000	4,720,000	-10,026,000										-3,742,000															-11,997,000	-5,693,000
acquired in-process research & development expense		0
proceeds from sale of nonfinancial assets						0	0	0	10,000,000					-6,675,000	0	0	110,000,000					0	0	0	67,159,000
purchase of intangible assets		-2,368,000	-5,303,000			-769,000	-2,713,000	-512,000	-8,000,000	-7,779,000	-1,684,000	-1,147,000	-310,000	-671,000	-7,171,000	-881,000	-1,858,000	-15,621,000	-1,626,000	-3,653,000	-2,747,000	-8,838,000	-3,583,000	-7,323,000	-3,463,000	-10,057,000	-2,553,000
acquisition, net of cash acquired		0
proceeds from exercises of awards under equity incentive plans		6,746,000	7,000			7,862,000	4,797,000	29,421,000	7,197,000	14,805,000	4,355,000	29,024,000	21,169,000	25,467,000	14,373,000	21,258,000	8,235,000	16,317,000	5,237,000	21,823,000	5,817,000	11,645,000	13,341,000	36,811,000	10,116,000	9,843,000	2,755,000	13,215,000	5,798,000	55,643,000	44,926,000	13,134,000
repayments of convertible debt						0
net increase in cash and cash equivalents		61,571,000	36,292,000	165,013,000	105,961,000	267,394,000	-296,702,000			-30,287,000	91,033,000	114,307,000	-144,457,000	-36,984,000	141,713,000	14,362,000	18,164,000	-29,867,000	-24,390,000	-25,780,000	18,155,000	-366,517,000	196,775,000	342,268,000	39,186,000	14,226,000				284,156,000						310,309,000		-126,587,000	-499,140,000	-434,822,000	25,084,000	387,216,000	6,120,000	-803,000	3,573,000							-24,607,000	-8,272,000	-14,529,000	-8,321,000	-48,317,000	19,008,000	-67,781,000	91,647,000
cash and cash equivalents:
cash paid for interest		3,673,000	-65,000			3,707,000	1,528,000	3,706,000	1,420,000	3,663,000	1,465,000	3,738,000	1,437,000	3,706,000	1,438,000	3,715,000	1,422,000		1,478,000	3,730,000	1,465,000		1,461,000	2,751,000	1,403,000		1,482,000	2,812,000	1,483,000			1,528,000																					2,155,000	3,045,000	2,153,000	3,045,000	2,146,000
impairment of assets and other noncash adjustments
increase in accounts payable and accrued liabilities related to fixed assets			2,293,000	6,479,000	-1,758,000	-15,187,000	-3,484,000	3,774,000	8,167,000	-7,813,000	-692,000
increase in accounts payable and accrued liabilities related to intangible assets			-3,878,000			8,442,000				455,000	8,793,000			966,000	-6,787,000	7,200,000	-637,000	39,000	7,992,000	99,000	1,298,000	2,751,000	-520,000
decrease in accounts payable and accrued liabilities related to intangible assets								16,802,000	-8,512,000				-1,478,000
amortization of premium (accretion of discount) on investments										-2,447,000	-2,248,000	-2,563,000	-1,970,000										137,000
impairment of assets and other non-cash adjustments						0	5,685,000
unrealized foreign exchange loss						5,599,000	-2,394,000	-9,154,000	-10,804,000	22,992,000	-2,001,000	840,000	6,615,000				-6,887,000	-463,000			3,950,000	-1,071,000	6,881,000	-7,199,000	9,400,000	241,000	-15,000	1,218,000	-419,000			5,616,000	4,348,000
non-cash changes in the fair value of contingent consideration														-539,000	905,000	-651,000	1,989,000	1,772,000	1,766,000	2,233,000	2,255,000	3,148,000	1,936,000	-580,000	-4,000	-441,000	755,000	-7,369,000	12,260,000
accounts payable and other short-term liabilities						-100,259,000	122,280,000	4,745,000	-59,006,000	12,520,000	81,426,000	6,593,000	-31,686,000	61,416,000	73,947,000
payments of contingent consideration										0	0	0	-9,475,000
principal repayments of financing leases								-18,000	-42,000	-45,000	-606,000	-621,000	-1,014,000	-970,000	-513,000	-556,000	-566,000	-547,000	-551,000	-857,000	-1,084,000	-838,000	-4,033,000	-1,104,000	-943,000
net decrease in cash and cash equivalents									-8,131,000																			-56,792,000	-129,613,000		-170,617,000	-124,048,000	23,069,000	-53,466,000	-60,096,000		-91,071,000									-24,982,000		-39,460,000	11,760,000	6,816,000	-58,208,000
loss on equity investment											0	0	12,650,000
decrease in accounts payable and accrued liabilities related to fixed assets													-8,430,000	3,758,000			-2,481,000		1,703,000	3,402,000	-12,795,000		9,978,000	-3,332,000	-19,927,000		-2,334,000	35,000	-3,502,000	-7,678,000	-7,734,000	-11,367,000	-25,047,000	-29,300,000	-26,297,000	-13,988,000	-17,130,000	-14,788,000	-11,386,000	-6,911,000	-20,985,000		14,616,000
amortization of premium on investments														-698,000	671,000	1,418,000	1,652,000	1,876,000	1,401,000	1,205,000	673,000
inventory reserves, net of stock-based compensation
investment in convertible note																						0	0
repurchase of common stock																						0	0
proceeds from convertible senior subordinated note offering																						0	-30,000										481,713,000
payment of contingent consideration															0
purchases of available-for-sale securities																	-147,361,000		-252,572,000	-247,401,000	-237,171,000		-48,258,000	-281,580,000	-40,104,000		-142,177,000	-146,477,000	-239,843,000	-439,198,000	-345,458,000	-145,933,000
stock-based compensation expense
purchase of available-for-sale debt securities
cash paid for interest, net of interest capitalized into fixed assets																														7,521,000	5,831,000		4,287,000	4,519,000		4,564,000	4,521,000		4,979,000	5,133,000	309,000	-1,079,000	205,000	3,068,000	230,000	3,196,000	336,000	3,402,000	2,151,000	2,702,000	1,822,000
adjustments to reconcile net loss to net cash from operating activities:
inventory write-off, net of stock-based compensation
payment of contingent acquisition consideration																											-1,000			-43,108,000	-43,108,000
(accretion of discount) amortization of premium on investments																									60,000
net loss																										15,024,000	55,036,000	-37,435,000	-56,473,000	-73,561,000	-60,941,000	-44,149,000	-65,650,000	-53,123,000	-16,290,000	-551,499,000	-508,702,000	-85,142,000	-240,416,000	-149,490,000	-67,501,000
gain on sale of intangible assets																										-10,000,000	0			-20,000,000	-20,000,000
gain on sale of equity investment																																							-3,022,000	-3,022,000
proceeds from sale of intangible asset																														20,000,000	20,000,000
conversion of convertible debt																																	22,477,000	22,477,000		8,924,000	6,941,000		8,957,000	8,133,000	8,133,000	16,269,000	31,512,000
proceeds from sale of intangible assets
supplemental cash flow disclosures for non cash investing and financing activities:
loss on sale of equity investment																																				2,020,000	2,027,000
non-cash changes in the fair value of contingent consideration\
business acquisitions, net of cash acquired																																				-1,467,000	-1,467,000		-538,392,000	-538,392,000	-538,392,000	0	0					0	-18,826,000	0	-14,124,000
proceeds from public offering of common stock																																				712,938,000			888,257,000	888,257,000	888,257,000			0	55,000
gain on the sale of equity investments																																		-3,252,000	-3,252,000
non-cash changes in the fair value of contingent acquisition consideration																														12,836,000	1,828,000
non-cash changes in the fair value of contingent acquisition consideration payable																																5,631,000	3,382,000	7,195,000	1,353,000	-56,954,000	-59,066,000	2,936,000	15,101,000	14,606,000	282,000
payment of contingent acquisition consideration payable																																	-1,894,000	-1,894,000	-1,894,000											0
depreciation and amortization expense
gain on sale of intangible asset
deposit on purchase of pku rights
stock-based compensation capitalized into inventory																																	12,077,000	7,600,000	3,226,000	8,960,000	5,751,000	2,469,000	8,271,000	5,492,000	2,480,000	1,902,000	1,829,000	1,305,000	1,181,000	1,320,000	1,499,000	1,434,000	1,381,000	1,244,000	1,080,000	1,327,000	1,424,000	1,369,000	1,303,000	1,295,000	1,274,000
depreciation capitalized into inventory																																	17,899,000	11,752,000	5,508,000	13,402,000	7,880,000	2,617,000	11,005,000	7,316,000	3,580,000	2,795,000	2,830,000	2,591,000	2,469,000	2,509,000	2,065,000	2,480,000	2,045,000	1,543,000	1,466,000	1,173,000	1,920,000	689,000	650,000	714,000	741,000
loss on the sale of equity investments																																	-3,252,000
impairment of intangible assets																																										0	0	0	0
funds held in escrow for the purchase of real property																																				-8,383,000			-12,500,000
purchase of available-for-sale securities																																	-609,794,000	-130,986,000	-54,388,000	-370,393,000
proceeds from exercises of stock options and the espp																																	46,119,000	40,659,000		49,498,000	23,014,000
accrual for inventory purchases related to the acquisition of the merck pku business																																				1,322,000	1,322,000	2,436,000
unrealized foreign exchange gain on forward contracts																																		-4,870,000	-1,730,000	-10,961,000	-7,882,000	-6,526,000		-10,203,000	-5,686,000					1,475,000								1,699,000	1,624,000	176,000	-304,000	61,000	-161,000
proceeds from exercises of stock options and the employee stock purchase plan																																			13,086,000
gain on termination of leases
purchase of available-for-sale investments																																					-58,914,000	-58,914,000	-842,873,000	-729,263,000	-288,431,000	-215,850,000	-61,011,000	-105,351,000	-64,346,000	-131,000	-82,733,000
investment in convertible promissory note
excess tax benefit from stock option exercises																																				-563,000	-314,000	-99,000	-463,000	-385,000	-527,000	-398,000	118,000	-377,000	-12,000	-306,000	-81,000	-509,000	-19,000			18,000	0	-127,000	-4,000
purchase of promissory note																																						-150,000	-3,326,000	-3,326,000	-3,326,000
proceeds from exercises of stock options and employee stock purchase plan																																						3,521,000	51,515,000	45,427,000	28,026,000
debt conversion expense																																									163,000	813,000	1,732,000			0
proceeds from convertible senior note offering
purchase of capped call share options
payments for debt conversion																																									-163,000	-813,000	-1,732,000
supplemental cash flow disclosures from investing and financing activities:
gain on termination of lease
unrealized foreign exchange loss on forward contracts																																							-16,491,000				-295,000
release of escrow balance for purchase of san rafael corporate center
equity in the loss of biomarin/genzyme llc																																									150,000	438,000	147,000	253,000	336,000	609,000	608,000	796,000	640,000	864,000	691,000		1,320,000	-94,000	547,000
deferred offering costs reclassified into additional paid-in-capital as a result of conversion of convertible debt																																									45,000	147,000	303,000
restricted funds held in escrow for the purchase of san rafael corporate center
investments in biomarin/genzyme llc																																										-400,000	0	-485,000	0	0	-655,000	-718,000	-1,450,000	0	-1,465,000	-740,000
proceeds from exercises of stock options and espp																																										12,094,000	14,293,000
unrealized foreign exchange (gain) loss on forward contracts																																																-551,000	-2,194,000	-1,415,000	-60,000	-3,725,000
other non-cash movements
investment in biomarin/genzyme llc
proceeds from exercises of stock options
payment on maturity of 2013 convertible note																																										0	0
repayment of capital lease obligations																																										-79,000	-144,000	-143,000	-142,000	-355,000	-53,000	-77,000	-33,000	-42,000	-43,000	-49,000	-45,000	-43,000	-48,000
loss on conversion of convertible promissory note
restricted funds held in escrow
purchase of intellectual property
increase in asset retirement obligation
changes in the fair value of contingent acquisition consideration payable																																											8,832,000	12,113,000	617,000	595,000	2,234,000	-607,000	3,143,000	799,000	654,000
decrease in accrued liabilities related to fixed assets																																													318,000
net gain from sale of investments																																																25,000	0	0	-927,000	0
payment on debt conversion
increase in accrued liabilities related to fixed assets
deferred offering costs reclassified into additional paid-in capital as a result of conversion of convertible debt
common stock transferred into the nonqualified deferred compensation plan
equipment acquired through capital leases																																														96,000	-176,000
amortization of discount on investments																																													1,337,000	981,000	1,002,000
proceeds from exercise of stock options and employee stock purchase plan																																													10,381,000
net payment on debt conversion																																														0
change in asset retirement obligation																																													49,000
net provided by investing activities
imputed interest on acquisition obligation																																																				0	-282,000	1,782,000	1,077,000	1,083,000	1,089,000	1,098,000	1,108,000	1,117,000	1,128,000	1,136,000	1,146,000
impairment loss on equity investments																																																				0
proceeds from espp and exercise of stock options																																																			9,183,000			1,914,000	891,000	3,048,000	3,872,000	7,268,000	14,255,000	5,046,000	6,658,000	2,076,000	1,440,000
repayment of acquisition obligation																																																				0	0	-72,100,000	-1,500,000	-1,500,000	-1,500,000	-1,750,000	-1,750,000	-1,750,000	-1,750,000	-1,750,000	-1,750,000
asset retirement obligation
proceeds from employee stock purchase plan (espp) and exercise of stock options																																															11,858,000	13,215,000	6,722,000
cash flows from investing activities
changes in accrued liabilities related to fixed assets																																																2,649,000	-13,396,000	1,313,000	4,477,000	-1,276,000	-19,000	-516,000	1,996,000	7,333,000	-3,725,000
changes in contingent acquisition consideration payable																																																	3,143,000	-19,657,000	21,110,000
amortization of discount (premium) on investments																																																947,000	1,005,000	1,303,000	1,198,000	954,000
deferred revenue																																																213,000	0	-158,000	72,000	-63,000	-780,000	809,000	-187,000	-1,136,000	-1,793,000	-1,643,000	-448,000	-1,586,000	-1,750,000	-1,788,000	-1,664,000
distributions from biomarin/genzyme llc																																																								0	4,000	0	16,679,000	0	6,200,000	4,900,000	6,000,000
investment in equity securities
payment of contingent acquisition payable																																																-9,631,000	0
beginning of year
end of year
distribution of inventory from the joint venture restructure
equipment acquired through capital lease obligations
accounts payable, accrued liabilities and other current liabilities																																																	2,565,000	8,322,000	-6,483,000
purchase of property, plant and equipment																																																	-9,372,000	-15,240,000	-14,108,000								-19,889,000		-5,648,000
purchase of investments																																																	-59,414,000	-26,516,000	-62,956,000	-106,893,000	-61,287,000
supplemental non-cash investing and financing activities disclosures:
investment in la jolla pharmaceutical company																																																				0	0	0	-6,250,000
equity in the (income) loss of biomarin/genzyme llc																																																										587,000	533,000
other liabilities																																																				-819,000	384,000	984,000	138,000	-326,000	995,000	148,000	143,000	-771,000	-425,000	798,000	401,000
investment in summit corporation plc
acquisition of huxley pharmaceuticals, inc.
payment to lead therapeutics, inc.
net proceeds from convertible debt offering
conversion of convertible notes																																																								157,000	6,000
distribution of inventory resulting from the joint venture restructure																																																								0	0
equipment acquired through capital lease																																																								90,000	143,000
deferred offering costs reclassified to additional paid in capital as a result of convertible notes																																																								5,000	0
common shares transferred to nonqualified deferred compensation plan
advances to biomarin/genzyme llc																																																					-91,000			32,000	42,000	75,000	1,764,000	-134,000	-651,000	-488,000	782,000
purchase of property and equipment																																																					-26,559,000	-21,884,000	-18,737,000	-11,923,000	-12,113,000						-3,235,000
proceeds from employee stock purchase plan and exercise of stock options
impairment loss on investments																																																						0	5,848,000
gain on sale of investments
amortization of discount on short-term investments																																																							-643,000	-1,018,000	-1,187,000	-1,443,000	-2,839,000	-3,445,000	-3,638,000	-3,177,000	-2,193,000
maturities and sales of short-term investments																																																							110,100,000	160,924,000	155,848,000	189,850,000	254,556,000
purchase of short-term investments																																																							-112,801,000	-201,731,000	-124,732,000	-257,643,000	-149,025,000	-251,445,000	-166,883,000	-317,178,000	-103,358,000
equity in the income of biomarin/genzyme llc																																																												-9,366,000	-8,446,000	-6,550,000	-6,163,000
impairment loss on investment
decrease in cash balances related to long-term debt
repayment of equipment and facility loans
net proceeds from public offering of common stock
cash flows from operating activities
investment summit corporation plc
settlement of forward contracts																																																									2,033,000	-256,000	-959,000
loss on disposals and impairment of property and equipment
loss on disposals and impairments of property and equipment
cash flows from financing activities
effect of foreign currency translation on cash																																																												-1,000	101,000	1,000	1,000
decrease in restricted cash
sale of short-term investments																																																												192,513,000	258,395,000	112,656,000	130,250,000
settlement of dispute with medicis
proceeds from equipment and facility loans
increase in cash balances related to long-term debt
loss on disposals of property and equipment																																																													0	0	9,000
net settlement of foreign currency forward contracts																																																													-525,000	-73,000	-53,000
proceeds from convertible debt offering																																																													0
net increase in cash																																																													86,815,000	106,679,000	9,169,000
stock based compensation																																																														4,691,000	3,815,000
acquired in-process research and development
impairment of acquired intangible assets
gain on disposals and impairments of property and equipment
notes receivable from officer
acquisition of ascent pediatrics
sales of short-term investments
purchases of short-term investments
reclassification of amounts (to) from cash balances related to long-term debt
proceeds from convertible debt offering, net of offering costs

BioMarin Pharmaceutical Inc(NASDAQ:BMRN)

BioMarin Pharmaceutical Inc
(NASDAQ:BMRN)