BeiGene, Ltd(NASDAQ:BGNE)

BeiGene, Ltd., a commercial-stage biotechnology company, engages in discovering, developing, manufacturing, and commercializing medicines for cancer therapeutics in the People's Republic of China and the United States. Its commercial products include BRUKINSA to treat relapsed/refractory (R/R) mantl...
Website: http://www.beigene.com
Founded: 2010
Full Time Employees: 9,400 (Dec 2022)
Sector: Healthcare
Industry: Biotechnology
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Quarterly
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| Unit: USD | 2026-03-31 | 2025-12-31 | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2017-12-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | 2016-09-30 | 2016-06-30 | 2016-03-31 | 2015-12-31 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
revenues | |||||||||||||||||||||||||||||||||||||||||
product revenue | 1,487,329,000 | 1,476,442,000 | 1,395,013,000 | 1,302,076,000 | 1,108,530,000 | 1,118,035,000 | 993,447,000 | 921,146,000 | 746,918,000 | 630,526,000 | 595,290,000 | 553,745,000 | 410,291,000 | 339,022,000 | 349,506,000 | 304,511,000 | 261,573,000 | 196,785,000 | 192,461,000 | 138,624,000 | 106,117,000 | 100,100,000 | 91,080,000 | 65,635,000 | 52,059,000 | 56,892,000 | 50,141,000 | 58,142,000 | 57,421,000 | 37,762,000 | 38,447,000 | 31,426,000 | 23,250,000 | 15,606,000 | 8,822,000 | ||||||
other revenue | 26,109,000 | 21,728,000 | 17,271,000 | ||||||||||||||||||||||||||||||||||||||
total revenues | 1,513,438,000 | 1,498,170,000 | 1,412,284,000 | 1,315,300,000 | 1,117,279,000 | 1,127,824,000 | 1,001,599,000 | 929,166,000 | 751,652,000 | 634,409,000 | 781,308,000 | 595,261,000 | 447,801,000 | 380,095,000 | 387,628,000 | 341,572,000 | 306,626,000 | 213,979,000 | 206,440,000 | 149,992,000 | 605,872,000 | 100,100,000 | 91,080,000 | 65,635,000 | 52,059,000 | 56,892,000 | 50,141,000 | 243,346,000 | 77,833,000 | 58,670,000 | 54,202,000 | 52,804,000 | 32,544,000 | 18,174,000 | 220,213,000 | ||||||
yoy | 35.46% | 32.84% | 41.00% | 41.56% | 48.64% | 77.78% | 28.20% | 56.09% | 67.85% | 66.91% | 101.56% | 74.27% | 46.04% | 77.63% | 87.77% | 127.73% | -49.39% | 113.77% | 126.66% | 128.52% | 1063.82% | 75.95% | 81.65% | -73.03% | -33.11% | -3.03% | -7.49% | 360.85% | 139.16% | 222.82% | -75.39% | ||||||||||
qoq | 1.02% | 6.08% | 7.37% | 17.72% | -0.93% | 12.60% | 7.80% | 23.62% | 18.48% | -18.80% | 31.25% | 32.93% | 17.81% | -1.94% | 13.48% | 11.40% | 43.30% | 3.65% | 37.63% | -75.24% | 505.27% | 9.90% | 38.77% | 26.08% | -8.50% | 13.46% | -79.40% | 212.65% | 32.66% | 8.24% | 2.65% | 62.25% | 79.07% | -91.75% | |||||||
cost of sales - product | 167,215,000 | 142,422,000 | 196,510,000 | 164,606,000 | 165,002,000 | 160,560,000 | 170,462,000 | 138,132,000 | 124,935,000 | 105,832,000 | 96,309,000 | 95,990,000 | 81,789,000 | 73,522,000 | 76,543,000 | 71,173,000 | 65,237,000 | 48,545,000 | 47,413,000 | 36,263,000 | 32,685,000 | 21,078,000 | 21,123,000 | 14,307,000 | 14,149,000 | -17,984,000 | -20,106,000 | -17,839,000 | -15,261,000 | -9,193,000 | -8,706,000 | -6,256,000 | -4,550,000 | -3,030,000 | -1,944,000 | ||||||
gross profit | 1,346,223,000 | 1,355,748,000 | 1,215,774,000 | 1,150,694,000 | 952,277,000 | 967,264,000 | 831,137,000 | 791,034,000 | 626,717,000 | 528,577,000 | 684,999,000 | 499,271,000 | 366,012,000 | 306,573,000 | 311,085,000 | 270,399,000 | 241,389,000 | 165,434,000 | 159,027,000 | 113,729,000 | 573,187,000 | 79,022,000 | 69,957,000 | 51,328,000 | 37,910,000 | 38,908,000 | 30,035,000 | 225,507,000 | 62,572,000 | 49,477,000 | 45,496,000 | 46,548,000 | 27,994,000 | 15,144,000 | 218,269,000 | ||||||
yoy | 41.37% | 40.16% | 46.28% | 45.47% | 51.95% | 82.99% | 21.33% | 58.44% | 71.23% | 72.41% | 120.20% | 84.64% | 51.63% | 85.31% | 95.62% | 137.76% | -57.89% | 109.35% | 127.32% | 121.57% | 1411.97% | 103.10% | 132.92% | -77.24% | -39.41% | -21.36% | -33.98% | 384.46% | 123.52% | 226.71% | -79.16% | ||||||||||
qoq | -0.70% | 11.51% | 5.66% | 20.84% | -1.55% | 16.38% | 5.07% | 26.22% | 18.57% | -22.84% | 37.20% | 36.41% | 19.39% | -1.45% | 15.05% | 12.02% | 45.91% | 4.03% | 39.83% | -80.16% | 625.35% | 12.96% | 36.29% | 35.39% | -2.57% | 29.54% | -86.68% | 260.40% | 26.47% | 8.75% | -2.26% | 66.28% | 84.85% | -93.06% | |||||||
gross margin % | 88.95% | 90.49% | 86.09% | 87.49% | 85.23% | 85.76% | 82.98% | 85.13% | 83.38% | 83.32% | 87.67% | 83.87% | 81.74% | 80.66% | 80.25% | 79.16% | 78.72% | 77.31% | 77.03% | 75.82% | 94.61% | 78.94% | 76.81% | 78.20% | 72.82% | 68.39% | 59.90% | 92.67% | 80.39% | 84.33% | 83.94% | 88.15% | 86.02% | 83.33% | 99.12% | NaN% | NaN% | NaN% | NaN% | NaN% | |
operating expenses | |||||||||||||||||||||||||||||||||||||||||
research and development | 541,224,000 | 615,423,000 | 523,662,000 | 524,896,000 | 481,887,000 | 542,012,000 | 496,179,000 | 454,466,000 | 460,638,000 | 493,987,000 | 453,259,000 | 422,764,000 | 408,584,000 | 446,023,000 | 426,363,000 | 378,207,000 | 389,915,000 | 430,485,000 | 351,937,000 | 356,091,000 | 320,726,000 | 355,537,000 | 349,070,000 | 285,968,000 | 304,302,000 | -283,259,000 | -236,968,000 | -228,760,000 | -178,351,000 | -257,464,000 | -147,590,000 | -164,251,000 | -109,700,000 | -91,340,000 | -87,660,000 | -47,245,000 | |||||
selling, general and administrative | 555,097,000 | 555,290,000 | 528,998,000 | 537,913,000 | 459,288,000 | 504,677,000 | 455,223,000 | 443,729,000 | 427,427,000 | 416,547,000 | 364,421,000 | 395,034,000 | 328,499,000 | 328,984,000 | 322,892,000 | 331,403,000 | 294,573,000 | 306,501,000 | 269,227,000 | 232,289,000 | 182,106,000 | 208,209,000 | 160,837,000 | 124,049,000 | 107,081,000 | -143,354,000 | -105,002,000 | -82,248,000 | -57,645,000 | -72,490,000 | -48,820,000 | -45,160,000 | -28,915,000 | -27,415,000 | -15,641,000 | ||||||
total operating expenses | 1,096,321,000 | 1,170,713,000 | 1,052,660,000 | 1,062,809,000 | 941,175,000 | 1,046,689,000 | 951,402,000 | 898,195,000 | 888,065,000 | -58,022,000 | |||||||||||||||||||||||||||||||
income from operations | 249,902,000 | 185,035,000 | 163,114,000 | 87,885,000 | 11,102,000 | -79,425,000 | -120,265,000 | -107,161,000 | -261,348,000 | -383,795,000 | -133,968,000 | -318,715,000 | -371,258,000 | -468,622,000 | -438,357,000 | -439,399,000 | -443,287,000 | -571,739,000 | -462,325,000 | -474,838,000 | 70,167,000 | -484,912,000 | -440,137,000 | -358,877,000 | -373,756,000 | -388,037,000 | -312,266,000 | -85,833,000 | -173,755,000 | -280,808,000 | -151,102,000 | -163,050,000 | -110,809,000 | -103,798,000 | 114,905,000 | -58,022,000 | |||||
yoy | 2150.96% | -332.97% | -235.63% | -182.01% | -104.25% | -79.31% | -10.23% | -66.38% | -29.60% | -18.10% | -69.44% | -27.47% | -16.25% | -18.04% | -5.18% | -7.46% | -731.76% | 17.91% | 5.04% | 32.31% | -118.77% | 24.97% | 40.95% | 318.11% | 115.11% | 38.19% | 106.66% | -47.36% | 56.81% | 170.53% | -231.50% | 181.01% | |||||||||
qoq | 35.06% | 13.44% | 85.60% | 691.61% | -113.98% | -33.96% | 12.23% | -59.00% | -31.90% | 186.48% | -57.97% | -14.15% | -20.78% | 6.90% | -0.24% | -0.88% | -22.47% | 23.67% | -2.64% | -776.73% | -114.47% | 10.17% | 22.64% | -3.98% | -3.68% | 24.26% | 263.81% | -50.60% | -38.12% | 85.84% | -7.33% | 47.15% | 6.75% | -190.33% | -298.04% | ||||||
operating margin % | 16.51% | 12.35% | 11.55% | 6.68% | 0.99% | -7.04% | -12.01% | -11.53% | -34.77% | -60.50% | -17.15% | -53.54% | -82.91% | -123.29% | -113.09% | -128.64% | -144.57% | -267.19% | -223.95% | -316.58% | 11.58% | -484.43% | -483.24% | -546.78% | -717.95% | -682.06% | -622.78% | -35.27% | -223.24% | -478.62% | -278.78% | -308.78% | -340.49% | -571.13% | 52.18% | -Infinity% | NaN% | NaN% | NaN% | NaN% | |
interest income | 27,664,000 | 58,131,000 | 3,029,000 | 3,497,000 | 5,848,000 | 7,808,000 | 10,643,000 | 13,225,000 | 16,160,000 | 16,274,000 | 26,649,000 | 15,070,000 | 16,016,000 | 18,219,000 | 12,759,000 | 11,431,000 | 10,071,000 | -4,482,000 | -2,230,000 | -4,866,000 | -4,179,000 | -5,186,000 | -614,000 | 1,108,000 | 6,690,000 | -438,000 | 2,206,000 | 2,886,000 | 4,477,000 | 5,950,000 | 4,553,000 | 1,892,000 | 1,552,000 | -527,000 | -1,785,000 | -1,982,000 | 186,000 | 209,000 | 262,000 | 494,000 | |
interest expense | -32,887,000 | ||||||||||||||||||||||||||||||||||||||||
other income | 14,536,000 | -35,691,000 | -18,979,000 | 8,167,000 | 3,950,000 | -13,734,000 | 11,318,000 | 1,762,000 | 16,749,000 | 336,657,000 | 18,303,000 | 19,438,000 | -125,640,000 | 11,967,000 | -10,583,000 | 31,477,000 | -867,000 | -4,123,000 | 8,122,000 | 5,711,000 | 19,976,000 | 3,681,000 | 8,141,000 | -1,817,000 | -878,000 | 1,728,000 | -396,000 | 1,585,000 | 75,000 | 729,000 | 9,926,000 | 1,103,000 | -477,000 | 905,000 | 198,000 | 748,000 | 315,000 | ||||
income before income taxes | 259,215,000 | 149,241,000 | 147,164,000 | 99,549,000 | 20,900,000 | -85,351,000 | -98,304,000 | -105,920,000 | -243,426,000 | -350,772,000 | 229,338,000 | -367,463,000 | -336,939,000 | -430,965,000 | -551,238,000 | -557,585,000 | -421,249,000 | -586,804,000 | -433,078,000 | -480,571,000 | 61,865,000 | -481,976,000 | -435,040,000 | -337,793,000 | -363,385,000 | -140,813,000 | -311,877,000 | -83,825,000 | -167,550,000 | ||||||||||||
income tax expense | 31,858,000 | 82,739,000 | 22,323,000 | 5,229,000 | 19,630,000 | 66,530,000 | 23,046,000 | 14,485,000 | 7,724,000 | 16,781,000 | 13,925,000 | 13,674,000 | 11,492,000 | 14,370,000 | 6,318,000 | 13,864,000 | 13,025,000 | -230,000 | -4,630,000 | -1,475,000 | 1,554,000 | -201,000 | |||||||||||||||||||
net income | 227,357,000 | 66,502,000 | 124,841,000 | 94,320,000 | 1,270,000 | -151,881,000 | -121,350,000 | -120,405,000 | -251,150,000 | -367,553,000 | 215,413,000 | -381,137,000 | -348,431,000 | -445,335,000 | -557,556,000 | -571,449,000 | -434,274,000 | -585,653,000 | -413,855,000 | -480,341,000 | 66,495,000 | -472,649,000 | -426,617,000 | -336,318,000 | -364,939,000 | -387,895,000 | -308,660,000 | -85,954,000 | -168,069,000 | -266,710,000 | -144,492,000 | -157,715,000 | -105,116,000 | -99,280,000 | 117,284,000 | -60,680,000 | |||||
yoy | 17802.13% | -143.79% | -202.88% | -178.34% | -100.51% | -58.68% | -156.33% | -68.41% | -27.92% | -17.47% | -138.64% | -33.30% | -19.77% | -23.96% | 34.72% | 18.97% | -753.09% | 23.91% | -2.99% | 42.82% | -118.22% | 21.85% | 38.22% | 291.28% | 117.14% | 45.44% | 113.62% | -45.50% | 59.89% | 168.64% | -223.20% | 159.91% | |||||||||
qoq | 241.88% | -46.73% | 32.36% | 7326.77% | -100.84% | 25.16% | 0.78% | -52.06% | -31.67% | -270.63% | -156.52% | 9.39% | -21.76% | -20.13% | -2.43% | 31.59% | -25.85% | 41.51% | -13.84% | -822.37% | -114.07% | 10.79% | 26.85% | -7.84% | -5.92% | 25.67% | 259.10% | -48.86% | -36.98% | 84.58% | -8.38% | 50.04% | 5.88% | -184.65% | -293.28% | ||||||
net income margin % | 15.02% | 4.44% | 8.84% | 7.17% | 0.11% | -13.47% | -12.12% | -12.96% | -33.41% | -57.94% | 27.57% | -64.03% | -77.81% | -117.16% | -143.84% | -167.30% | -141.63% | -273.70% | -200.47% | -320.24% | 10.98% | -472.18% | -468.40% | -512.41% | -701.01% | -681.81% | -615.58% | -35.32% | -215.94% | -454.59% | -266.58% | -298.68% | -323.00% | -546.27% | 53.26% | -Infinity% | NaN% | NaN% | NaN% | NaN% | |
earnings per share | |||||||||||||||||||||||||||||||||||||||||
basic | 0.16 | 0.04 | 0.09 | 0.07 | -0.09 | -0.09 | -0.095 | 0.16 | 0.06 | ||||||||||||||||||||||||||||||||
diluted | 0.15 | 0.04 | 0.08 | 0.06 | -0.09 | -0.09 | -0.095 | 0.15 | 0.05 | ||||||||||||||||||||||||||||||||
weighted-average shares outstanding—basic | 1,442,451,870 | 1,417,803,727 | 1,432,801,699 | 1,408,166,754 | 1,390,052,966 | 1,376,751,873 | 1,360,716,279 | 1,332,017,262 | 1,188,943,726 | ||||||||||||||||||||||||||||||||
weighted-average shares outstanding—diluted | 1,505,027,338 | 1,474,829,908 | 1,488,750,354 | 1,463,277,401 | 1,445,253,219 | 1,376,751,873 | 1,390,331,833 | 1,332,017,262 | 1,257,489,671 | ||||||||||||||||||||||||||||||||
earnings per american depositary share | |||||||||||||||||||||||||||||||||||||||||
basic | 2.05 | 0.6 | 1.13 | 0.87 | 0.01 | -1.178 | -1.15 | -1.23 | 2.06 | 0.73 | |||||||||||||||||||||||||||||||
diluted | 1.96 | 0.57 | 1.09 | 0.84 | 0.01 | -1.178 | -1.15 | -1.23 | 2.01 | 0.69 | |||||||||||||||||||||||||||||||
weighted-average adss outstanding—basic | 110,957,836 | 109,061,825 | 110,215,515 | 108,320,520 | 106,927,151 | 105,903,990 | 104,670,483 | 102,462,866 | 91,457,210 | ||||||||||||||||||||||||||||||||
weighted-average adss outstanding—diluted | 115,771,334 | 113,448,454 | 114,519,258 | 112,559,800 | 111,173,325 | 105,903,990 | 106,948,603 | 102,462,866 | 96,729,975 | ||||||||||||||||||||||||||||||||
collaboration revenue | 13,224,000 | 8,749,000 | 9,789,000 | 8,152,000 | 8,020,000 | 4,734,000 | 3,883,000 | 186,018,000 | 41,516,000 | 37,510,000 | 41,073,000 | 38,122,000 | 37,061,000 | 45,053,000 | 17,194,000 | 13,979,000 | 11,368,000 | 499,755,000 | 185,204,000 | 20,412,000 | 20,908,000 | 15,755,000 | 21,378,000 | 9,294,000 | 2,568,000 | 211,391,000 | 393,000 | 677,000 | |||||||||||||
amortization of intangible assets | 1,838,000 | 1,287,000 | 188,000 | 187,000 | 188,000 | 187,000 | 188,000 | 188,000 | 187,000 | 188,000 | 187,000 | 188,000 | 188,000 | 187,000 | 188,000 | 283,000 | -332,000 | -331,000 | -332,000 | -331,000 | -331,000 | -188,000 | -187,000 | -188,000 | -187,000 | -63,000 | |||||||||||||||
other expense | -11,984,000 | -63,818,000 | -129,617,000 | ||||||||||||||||||||||||||||||||||||||
net income per share | -0.09 | -0.19 | -0.28 | -0.26 | -0.33 | -0.41 | -0.43 | -0.4 | -0.37 | -0.33 | -0.36 | -0.5 | -0.39 | -0.11 | -0.22 | ||||||||||||||||||||||||||
weighted-average shares outstanding—basic and diluted | 1,368,746,793 | 1,361,082,567 | 1,355,547,626 | 1,357,034,547 | 1,360,224,377 | 1,354,164,760 | 1,345,303,747 | 1,336,463,026 | 1,205,971,284 | 1,194,071,476 | |||||||||||||||||||||||||||||||
net loss per american depositary share (“ads”), basic and diluted | -1.15 | -2.41 | -5.25 | -4.81 | -4.31 | -4.7 | -6.43 | -5.11 | -1.43 | -2.81 | |||||||||||||||||||||||||||||||
weighted-average adss outstanding—basic and diluted | 105,288,215 | 104,698,659 | 104,272,894 | 104,387,273 | 104,632,644 | 104,166,520 | 103,484,904 | 102,804,848 | 92,767,022 | 91,851,652 | |||||||||||||||||||||||||||||||
expenses | |||||||||||||||||||||||||||||||||||||||||
total expenses | 662,077,750 | 915,276,000 | 913,976,000 | 819,059,000 | 848,717,000 | 825,985,000 | 780,971,000 | 749,913,000 | 785,718,000 | 668,765,000 | 624,830,000 | 535,705,000 | 585,012,000 | 531,217,000 | 424,512,000 | 425,815,000 | -444,929,000 | -362,407,000 | -329,179,000 | -251,588,000 | -339,478,000 | -205,304,000 | -215,854,000 | -143,353,000 | -121,972,000 | -105,308,000 | |||||||||||||||
net loss per american depositary share | -3.64 | -3.34 | -3.785 | -5.39 | -5.56 | ||||||||||||||||||||||||||||||||||||
net income per share | -0.09 | -0.19 | -0.28 | -0.26 | -0.33 | -0.41 | -0.43 | -0.4 | -0.37 | -0.33 | -0.36 | -0.5 | -0.39 | -0.11 | -0.22 | ||||||||||||||||||||||||||
basic | -0.33 | -0.145 | -0.19 | 0.003 | 0.21 | ||||||||||||||||||||||||||||||||||||
diluted | -0.33 | -0.145 | -0.19 | 0.003 | 0.2 | ||||||||||||||||||||||||||||||||||||
net income per american depositary share | |||||||||||||||||||||||||||||||||||||||||
income tax benefit | -6,020,750 | -19,223,000 | -2,086,000 | -8,423,000 | -7,561,000 | 3,217,000 | -2,129,000 | -519,000 | 8,544,000 | 472,000 | 3,368,000 | 3,412,000 | 670,000 | 3,061,000 | |||||||||||||||||||||||||||
less: net loss attributable to noncontrolling interests | 96,000 | -1,393,000 | -1,116,000 | -1,204,000 | 166,000 | -1,303,000 | -384,000 | -429,000 | 1,545,000 | -461,000 | -828,000 | -520,000 | |||||||||||||||||||||||||||||
net loss attributable to beigene, ltd. | -585,653,000 | -413,855,000 | -480,341,000 | -472,745,000 | -425,224,000 | -335,202,000 | -363,735,000 | -388,061,000 | -307,357,000 | -85,570,000 | -167,640,000 | -156,887,000 | -104,596,000 | -60,545,000 | |||||||||||||||||||||||||||
loss per share attributable to beigene, ltd. | -0.173 | -0.34 | -0.4 | ||||||||||||||||||||||||||||||||||||||
loss per american depositary share | -2.248 | -4.46 | -5.23 | ||||||||||||||||||||||||||||||||||||||
net income attributable to beigene, ltd. | 66,495,000 | -101,378,500 | -144,031,000 | 1,554,500 | 117,386,000 | ||||||||||||||||||||||||||||||||||||
earnings per share attributable to beigene, ltd. | |||||||||||||||||||||||||||||||||||||||||
basic | 0.16 | 0.04 | 0.09 | 0.07 | -0.09 | -0.09 | -0.095 | 0.16 | 0.06 | ||||||||||||||||||||||||||||||||
diluted | 0.15 | 0.04 | 0.08 | 0.06 | -0.09 | -0.09 | -0.095 | 0.15 | 0.05 | ||||||||||||||||||||||||||||||||
weighted-average shares outstanding, basic and diluted | 1,340,729,572 | 1,206,210,049 | 1,085,131,783 | 1,148,973,077 | 1,010,230,470 | 1,005,347,581 | 780,701,283 | 781,482,459 | 777,509,102 | 774,750,255 | 720,753,819 | ||||||||||||||||||||||||||||||
weighted-average adss outstanding, basic and diluted | 103,133,044 | 92,785,388 | 83,471,676 | 88,382,544 | 77,710,036 | 77,334,429 | 60,053,945 | 60,114,035 | 59,808,392 | 59,596,173 | 55,442,601 | ||||||||||||||||||||||||||||||
income before income tax expense | -103,643,750 | -144,964,000 | 825,250 | 114,223,000 | |||||||||||||||||||||||||||||||||||||
weighted-average shares used for eps calculation | |||||||||||||||||||||||||||||||||||||||||
basic | 739,789,269 | 547,546,656 | |||||||||||||||||||||||||||||||||||||||
diluted | 739,789,269 | 600,612,680 | |||||||||||||||||||||||||||||||||||||||
weighted-average adss used in net income per share calculation | |||||||||||||||||||||||||||||||||||||||||
loss before income tax expense | -161,083,000 | -108,528,000 | -60,479,000 | ||||||||||||||||||||||||||||||||||||||
net income per share | -0.09 | -0.19 | -0.28 | -0.26 | -0.33 | -0.41 | -0.43 | -0.4 | -0.37 | -0.33 | -0.36 | -0.5 | -0.39 | -0.11 | -0.22 | ||||||||||||||||||||||||||
basic and diluted | -0.22 | -0.16 | |||||||||||||||||||||||||||||||||||||||
weighted-average shares used for eps calculation | |||||||||||||||||||||||||||||||||||||||||
basic and diluted | 698,506,891 | 670,510,605 | 543,185,460 | 517,663,736 | 516,437,707 | 428,137,509 | 427,746,711 | 294,042,572 | |||||||||||||||||||||||||||||||||
net loss per american depositary share | -3.64 | -3.34 | -3.785 | -5.39 | -5.56 | ||||||||||||||||||||||||||||||||||||
basic and diluted | -2.92 | -2.03 | |||||||||||||||||||||||||||||||||||||||
weighted-average adss used in net loss per share calculation | |||||||||||||||||||||||||||||||||||||||||
revenue | |||||||||||||||||||||||||||||||||||||||||
changes in fair value of financial instruments | |||||||||||||||||||||||||||||||||||||||||
gain on sale of available-for-sale securities | 34,000 | 2,000 | 8,000 | ||||||||||||||||||||||||||||||||||||||
less: net loss attributable to noncontrolling interest | -59,250 | -102,000 | -135,000 | ||||||||||||||||||||||||||||||||||||||
total revenue | 393,000 | 677,000 | |||||||||||||||||||||||||||||||||||||||
operating expenses: | |||||||||||||||||||||||||||||||||||||||||
general and administrative | -10,777,000 | ||||||||||||||||||||||||||||||||||||||||
loss per share | |||||||||||||||||||||||||||||||||||||||||
basic and diluted | -0.12 | ||||||||||||||||||||||||||||||||||||||||
weighted-average number of ordinary shares used in net loss per share calculation | |||||||||||||||||||||||||||||||||||||||||
basic and diluted | 698,506,891 | 670,510,605 | 543,185,460 | 517,663,736 | 516,437,707 | 428,137,509 | 427,746,711 | 294,042,572 | |||||||||||||||||||||||||||||||||
loss per american depositary share | -2.248 | -4.46 | -5.23 | ||||||||||||||||||||||||||||||||||||||
basic and diluted | -1.52 | ||||||||||||||||||||||||||||||||||||||||
loss per ads | |||||||||||||||||||||||||||||||||||||||||
basic and diluted | |||||||||||||||||||||||||||||||||||||||||
disposal loss on available-for-sale securities |
Balance Sheets:
Quarterly
Annual
| Unit: USD | 2026-03-31 | 2025-12-31 | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2017-12-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | 2016-09-30 | 2016-06-30 | 2016-03-31 | 2015-12-31 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
assets | |||||||||||||||||||||||||||||||||||||||||
current assets: | |||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents | 4,791,676,000 | 4,547,530,000 | 4,036,868,000 | 2,756,056,000 | 2,516,411,000 | 2,627,410,000 | 2,701,933,000 | 2,592,655,000 | 2,793,370,000 | 3,171,800,000 | 3,067,336,000 | 3,410,368,000 | 3,538,644,000 | 3,869,564,000 | 4,197,132,000 | 4,531,137,000 | 4,347,162,000 | 4,375,678,000 | 1,383,310,000 | 1,776,448,000 | 1,901,819,000 | 1,381,950,000 | 1,464,470,000 | 1,345,014,000 | 1,957,101,000 | 618,011,000 | 856,151,000 | 918,948,000 | 764,492,000 | 712,937,000 | 643,485,000 | 438,420,000 | 490,634,000 | 239,602,000 | 208,510,000 | 261,006,000 | 97,750,000 | 85,532,000 | 58,084,000 | 208,506,000 | |
accounts receivable | 938,019,000 | 865,080,000 | 863,281,000 | 770,776,000 | 717,239,000 | 676,278,000 | 569,047,000 | 529,449,000 | 435,294,000 | 358,027,000 | 309,079,000 | 299,282,000 | 309,628,000 | 173,168,000 | 189,170,000 | 172,259,000 | 190,800,000 | 483,113,000 | 129,584,000 | 73,787,000 | 84,010,000 | 60,403,000 | 60,266,000 | 61,663,000 | 65,620,000 | 70,878,000 | 55,912,000 | 58,108,000 | 58,976,000 | 41,056,000 | 37,372,000 | 33,171,000 | 23,485,000 | 29,428,000 | 10,521,000 | ||||||
inventories | 681,590,000 | 608,227,000 | 531,687,000 | 502,867,000 | 494,660,000 | 494,986,000 | 431,676,000 | 443,260,000 | 447,345,000 | 416,122,000 | 316,929,000 | 321,333,000 | 296,995,000 | 282,346,000 | 290,911,000 | 262,210,000 | 245,628,000 | 242,626,000 | 150,979,000 | 117,587,000 | 72,974,000 | 89,293,000 | 35,525,000 | 33,234,000 | 28,775,000 | 28,553,000 | 37,512,000 | 49,048,000 | 13,140,000 | 16,242,000 | 19,699,000 | 6,322,000 | 7,498,000 | 10,930,000 | 5,712,000 | ||||||
prepaid expenses and other current assets | 189,995,000 | 212,752,000 | 232,641,000 | 280,522,000 | 168,182,000 | 192,919,000 | 209,080,000 | 273,658,000 | 231,741,000 | 243,392,000 | 241,661,000 | 255,050,000 | 264,835,000 | 216,553,000 | 199,766,000 | 207,383,000 | 266,436,000 | 270,173,000 | 235,015,000 | 225,455,000 | 171,399,000 | 160,012,000 | 150,880,000 | 144,466,000 | 126,312,000 | 90,238,000 | 95,936,000 | 96,206,000 | 89,941,000 | 81,942,000 | 69,925,000 | 63,293,000 | 49,382,000 | 35,623,000 | 17,712,000 | 11,261,000 | 8,702,000 | 6,335,000 | 6,135,000 | 4,556,000 | |
total current assets | 6,601,280,000 | 6,233,589,000 | 5,664,477,000 | 4,310,221,000 | 3,896,492,000 | 3,991,593,000 | 3,911,736,000 | 3,839,022,000 | 3,907,750,000 | 4,203,414,000 | 4,053,542,000 | 4,401,419,000 | 4,704,318,000 | 5,207,078,000 | 5,749,168,000 | 6,345,876,000 | 6,948,139,000 | 7,613,880,000 | 4,432,835,000 | 4,799,039,000 | 5,140,979,000 | 4,960,690,000 | 4,965,736,000 | 3,392,404,000 | 3,595,187,000 | 1,172,696,000 | 1,435,550,000 | 1,755,680,000 | 1,796,730,000 | 1,943,842,000 | 2,180,195,000 | 1,516,707,000 | 1,585,702,000 | 913,497,000 | 962,330,000 | 418,691,000 | 336,178,000 | 209,953,000 | 232,754,000 | 251,782,000 | |
property, plant and equipment | 1,640,918,000 | 1,641,678,000 | 1,628,114,000 | 1,615,792,000 | 1,598,588,000 | 1,578,423,000 | 1,562,965,000 | 1,516,491,000 | 1,417,992,000 | 1,324,154,000 | 1,178,038,000 | 1,031,938,000 | 925,404,000 | 845,946,000 | 681,914,000 | 633,100,000 | 624,673,000 | 587,605,000 | 450,788,000 | 395,167,000 | 373,949,000 | 357,686,000 | 291,218,000 | 258,106,000 | 240,331,000 | 226,499,000 | 212,672,000 | 197,806,000 | |||||||||||||
operating lease right-of-use assets | 145,497,000 | 148,184,000 | 140,217,000 | 145,769,000 | 146,416,000 | 139,309,000 | 101,046,000 | 103,633,000 | 87,747,000 | 95,207,000 | 98,742,000 | 99,422,000 | 108,989,000 | 109,960,000 | 110,340,000 | 117,583,000 | 115,497,000 | 117,431,000 | 100,585,000 | 95,980,000 | 86,946,000 | 90,581,000 | 88,689,000 | 90,620,000 | 91,509,000 | 82,520,000 | 75,339,000 | 74,640,000 | 72,624,000 | ||||||||||||
intangible assets | 61,681,000 | 62,704,000 | 63,581,000 | 64,890,000 | 50,139,000 | 51,095,000 | 53,939,000 | 53,715,000 | 55,171,000 | 57,138,000 | 53,657,000 | 46,895,000 | 39,735,000 | 40,616,000 | 40,849,000 | 43,325,000 | 45,807,000 | 46,679,000 | 14,104,000 | 12,008,000 | 4,813,000 | 5,000,000 | 5,188,000 | 5,375,000 | 5,563,000 | 5,846,000 | 6,178,000 | 6,509,000 | 6,841,000 | 7,172,000 | 7,299,000 | 6,875,000 | 7,062,000 | 7,250,000 | 7,437,000 | ||||||
other non-current assets | 104,243,000 | 102,418,000 | 136,197,000 | 161,722,000 | 149,891,000 | 160,490,000 | 201,174,000 | 199,318,000 | 199,021,000 | 125,362,000 | 140,900,000 | 147,549,000 | 173,366,000 | 170,413,000 | 140,553,000 | 130,955,000 | 164,554,000 | 163,049,000 | 175,122,000 | 132,244,000 | 127,820,000 | 113,090,000 | 162,600,000 | 112,382,000 | 94,250,000 | 68,455,000 | 64,848,000 | 60,158,000 | 58,605,000 | 53,668,000 | 28,908,000 | 11,452,000 | 14,210,000 | 42,915,000 | 2,051,000 | 16,687,000 | 6,900,000 | 8,918,000 | 8,724,000 | 5,744,000 | |
total non-current assets | 1,952,339,000 | 1,954,984,000 | 1,968,109,000 | 1,988,173,000 | 1,945,034,000 | 1,929,317,000 | 1,919,124,000 | 1,873,157,000 | 1,759,931,000 | 1,601,861,000 | 1,471,337,000 | 1,327,317,000 | 1,252,457,000 | 1,172,212,000 | 976,845,000 | 1,032,331,000 | 1,073,249,000 | 1,032,069,000 | 853,499,000 | 725,077,000 | 680,025,000 | 640,067,000 | 600,654,000 | 510,886,000 | 472,025,000 | 439,593,000 | 445,520,000 | 394,638,000 | 375,502,000 | 305,842,000 | 228,432,000 | 137,149,000 | 123,225,000 | 132,982,000 | 86,729,000 | 55,284,000 | 40,551,000 | 25,472,000 | 18,476,000 | 13,446,000 | |
total assets | 8,553,619,000 | 8,188,573,000 | 7,632,586,000 | 6,298,394,000 | 5,841,526,000 | 5,920,910,000 | 5,830,860,000 | 5,712,179,000 | 5,667,681,000 | 5,805,275,000 | 5,524,879,000 | 5,728,736,000 | 5,956,775,000 | 6,379,290,000 | 6,726,013,000 | 7,378,207,000 | 8,021,388,000 | 8,645,949,000 | 5,286,334,000 | 5,524,116,000 | 5,821,004,000 | 5,600,757,000 | 5,566,390,000 | 3,903,290,000 | 4,067,212,000 | 1,612,289,000 | 1,881,070,000 | 2,150,318,000 | 2,172,232,000 | 2,249,684,000 | 2,408,627,000 | 1,653,856,000 | 1,708,927,000 | 1,046,479,000 | 1,049,059,000 | 473,975,000 | 376,729,000 | 235,425,000 | 251,230,000 | 265,228,000 | |
liabilities and shareholders’ equity | |||||||||||||||||||||||||||||||||||||||||
current liabilities: | |||||||||||||||||||||||||||||||||||||||||
accounts payable | 423,546,000 | 479,035,000 | 383,676,000 | 360,783,000 | 364,498,000 | 404,997,000 | 307,532,000 | 333,022,000 | 356,575,000 | 315,111,000 | 341,857,000 | 266,975,000 | 241,360,000 | 294,781,000 | 252,071,000 | 234,355,000 | 236,915,000 | 262,400,000 | 206,203,000 | 168,826,000 | 146,923,000 | 231,957,000 | 146,265,000 | 157,173,000 | 98,364,000 | 122,488,000 | 112,282,000 | 148,536,000 | 105,320,000 | 113,283,000 | 85,552,000 | 85,878,000 | 52,719,000 | 69,779,000 | 35,168,000 | 24,419,000 | 20,482,000 | 7,307,000 | 6,071,000 | 3,823,000 | |
accrued expenses and other payables | 1,079,283,000 | 1,109,120,000 | 1,001,661,000 | 908,882,000 | 692,179,000 | 803,713,000 | 717,343,000 | 646,538,000 | 569,438,000 | 693,731,000 | 505,824,000 | 454,950,000 | 417,922,000 | 467,352,000 | 410,255,000 | 454,183,000 | 385,976,000 | 558,055,000 | 389,874,000 | 398,856,000 | 312,134,000 | 346,144,000 | 279,323,000 | 207,921,000 | 179,331,000 | 163,556,000 | 133,020,000 | 103,061,000 | 90,737,000 | 100,414,000 | 75,882,000 | 75,037,000 | 55,712,000 | 49,598,000 | 46,991,000 | 22,427,000 | 24,463,000 | 21,715,000 | 14,226,000 | 11,577,000 | |
tax payable | 63,522,000 | 41,625,000 | 11,219,000 | 5,536,000 | 34,144,000 | 25,930,000 | 14,880,000 | 5,278,000 | 27,324,000 | 22,951,000 | 20,158,000 | 17,074,000 | 33,929,000 | 25,189,000 | 22,665,000 | 15,564,000 | 38,505,000 | 21,395,000 | 20,878,000 | 13,855,000 | 27,463,000 | 20,380,000 | 9,244,000 | 10,448,000 | 19,535,000 | 13,454,000 | 9,061,000 | 2,175,000 | 6,857,000 | 5,888,000 | 1,549,000 | 1,151,000 | 9,889,000 | 9,156,000 | 2,852,000 | 3,106,000 | 2,570,000 | 294,000 | 168,000 | 33,000 | |
operating lease liabilities, current portion | 20,584,000 | 20,698,000 | 15,732,000 | 17,250,000 | 18,303,000 | 17,576,000 | 17,707,000 | 17,658,000 | 19,401,000 | 21,950,000 | 23,246,000 | 23,508,000 | 24,545,000 | 24,041,000 | 24,340,000 | 24,788,000 | 22,894,000 | 21,925,000 | 18,644,000 | 16,550,000 | 13,993,000 | 13,895,000 | 13,280,000 | 12,888,000 | 14,597,000 | 10,814,000 | |||||||||||||||
research and development cost share liability, current portion | 35,700,000 | 64,345,000 | 90,596,000 | 108,992,000 | 111,127,000 | 111,154,000 | 104,067,000 | 84,615,000 | 81,986,000 | 68,004,000 | 63,652,000 | 62,516,000 | 69,510,000 | 114,335,000 | 115,721,000 | 125,394,000 | 120,971,000 | 120,801,000 | 153,838,000 | 145,820,000 | 135,333,000 | 127,808,000 | 147,387,000 | 136,704,000 | 128,672,000 | ||||||||||||||||
sale of future royalty liability, current portion | 72,735,000 | 56,714,000 | 52,245,000 | ||||||||||||||||||||||||||||||||||||||
short-term debt | 116,140,000 | 57,293,000 | 813,296,000 | 808,394,000 | 763,470,000 | 851,529,000 | 863,803,000 | 851,657,000 | 826,965,000 | 688,366,000 | 328,560,000 | 421,052,000 | 281,808,000 | 328,969,000 | 441,275,000 | 380,729,000 | 407,387,000 | 427,565,000 | 442,372,000 | 434,802,000 | 405,045,000 | 335,015,000 | 50,222,000 | ||||||||||||||||||
total current liabilities | 1,811,510,000 | 1,828,830,000 | 2,368,425,000 | 2,209,837,000 | 1,983,721,000 | 2,214,899,000 | 2,025,332,000 | 1,938,768,000 | 1,881,689,000 | 1,810,113,000 | 1,283,297,000 | 1,405,109,000 | 1,254,551,000 | 1,468,528,000 | 1,411,311,000 | 1,398,409,000 | 1,376,306,000 | 1,599,555,000 | 1,304,435,000 | 1,242,314,000 | 1,112,542,000 | 1,075,199,000 | 645,721,000 | 551,195,000 | 451,797,000 | 310,312,000 | 265,734,000 | 271,679,000 | 238,809,000 | 246,452,000 | 188,424,000 | 186,435,000 | 141,896,000 | 149,988,000 | 103,161,000 | 49,952,000 | 49,985,000 | 29,316,000 | 20,465,000 | 15,826,000 | |
non-current liabilities: | |||||||||||||||||||||||||||||||||||||||||
long-term debt | 962,515,000 | 961,913,000 | 139,571,000 | 146,091,000 | 160,157,000 | 166,484,000 | 197,618,000 | 209,148,000 | 202,113,000 | 151,551,000 | |||||||||||||||||||||||||||||||
sale of future royalty liability, non-current portion | 831,664,000 | 850,242,000 | 832,755,000 | ||||||||||||||||||||||||||||||||||||||
operating lease liabilities, non-current portion | 49,670,000 | 52,940,000 | 51,387,000 | 53,940,000 | 54,895,000 | 44,277,000 | 32,454,000 | 35,398,000 | 17,722,000 | 22,251,000 | 25,474,000 | 25,821,000 | 32,543,000 | 34,517,000 | 36,904,000 | 41,921,000 | 39,989,000 | 43,041,000 | 37,613,000 | 34,172,000 | 26,565,000 | 29,417,000 | 28,679,000 | 31,165,000 | 32,967,000 | 25,833,000 | |||||||||||||||
deferred tax liabilities | 55,866,000 | 53,209,000 | 47,066,000 | 44,093,000 | 43,110,000 | 42,007,000 | 15,935,000 | 15,942,000 | 16,437,000 | 16,494,000 | 16,358,000 | 15,652,000 | 16,061,000 | 15,996,000 | 15,249,000 | 14,739,000 | 14,219,000 | 14,169,000 | 13,266,000 | 12,270,000 | 10,794,000 | 10,792,000 | 11,884,000 | 11,379,000 | 10,368,000 | 10,532,000 | 10,681,000 | 11,802,000 | 11,333,000 | 11,139,000 | 1,859,000 | ||||||||||
other long-term liabilities | 81,952,000 | 80,245,000 | 64,056,000 | 63,079,000 | 65,629,000 | 66,735,000 | 50,568,000 | 51,533,000 | 48,901,000 | 50,510,000 | 41,986,000 | 43,118,000 | 45,619,000 | 46,095,000 | 45,169,000 | 48,432,000 | 51,828,000 | 54,234,000 | 54,606,000 | 55,331,000 | 55,320,000 | 57,429,000 | 47,890,000 | 46,514,000 | 45,305,000 | 46,562,000 | 36,580,000 | 38,101,000 | 38,972,000 | 38,931,000 | 34,879,000 | 21,772,000 | 22,902,000 | 31,959,000 | 744,000 | 1,123,000 | 893,000 | 247,000 | 165,000 | 89,000 | |
total non-current liabilities | 1,981,667,000 | 1,998,549,000 | 1,134,835,000 | 318,082,000 | 358,292,000 | 373,789,000 | 369,455,000 | 407,156,000 | 425,631,000 | 457,835,000 | 478,348,000 | 525,068,000 | 544,918,000 | 527,407,000 | 659,531,000 | 677,254,000 | 759,582,000 | 803,407,000 | 624,826,000 | 675,027,000 | 704,875,000 | 656,315,000 | 624,155,000 | 805,603,000 | 788,359,000 | 323,622,000 | 321,099,000 | 307,375,000 | 310,744,000 | 249,585,000 | 236,772,000 | 240,753,000 | 208,309,000 | 212,260,000 | 181,409,000 | 153,851,000 | 18,327,000 | 18,277,000 | 10,718,000 | 6,303,000 | |
total liabilities | 3,793,177,000 | 3,827,379,000 | 3,503,260,000 | 2,527,919,000 | 2,342,013,000 | 2,588,688,000 | 2,394,787,000 | 2,345,924,000 | 2,307,320,000 | 2,267,948,000 | 1,761,645,000 | 1,930,177,000 | 1,799,469,000 | 1,995,935,000 | 2,070,842,000 | 2,075,663,000 | 2,135,888,000 | 2,402,962,000 | 1,929,261,000 | 1,917,341,000 | 1,817,417,000 | 1,731,514,000 | 1,269,876,000 | 1,356,798,000 | 1,240,156,000 | 633,934,000 | 586,833,000 | 579,054,000 | 549,553,000 | 496,037,000 | 425,196,000 | 427,188,000 | 350,205,000 | 362,248,000 | 284,570,000 | 203,803,000 | 68,312,000 | 47,593,000 | 31,183,000 | 22,129,000 | |
commitments and contingencies | |||||||||||||||||||||||||||||||||||||||||
shareholders’ equity: | |||||||||||||||||||||||||||||||||||||||||
ordinary shares, 0.0001 par value per share... | 144,000 | 144,000 | 144,000 | 143,000 | 140,000 | 138,000 | 138,000 | 137,000 | 136,000 | 135,000 | 135,000 | 133,000 | 118,000 | 79,000 | 77,000 | ||||||||||||||||||||||||||
additional paid-in capital | 12,906,326,000 | 12,759,137,000 | 12,616,844,000 | 12,395,276,000 | 12,247,260,000 | 12,087,908,000 | 11,974,415,000 | 11,840,197,000 | 11,705,069,000 | 11,598,688,000 | 11,502,527,000 | 11,752,019,000 | 11,644,957,000 | 11,540,979,000 | 11,451,566,000 | 11,356,686,000 | 11,268,290,000 | 11,191,007,000 | 7,724,822,000 | 7,561,155,000 | 7,486,518,000 | 7,414,932,000 | 7,367,799,000 | 5,200,275,000 | 5,138,239,000 | 2,925,970,000 | 2,861,012,000 | 2,814,449,000 | 2,777,474,000 | 2,744,814,000 | 2,710,053,000 | 1,804,942,000 | 1,782,033,000 | 1,000,747,000 | 981,237,000 | 604,603,000 | 597,268,000 | 388,568,000 | 385,787,000 | 384,502,000 | 208,889,000 |
accumulated other comprehensive loss | -53,482,000 | -78,184,000 | -101,257,000 | -113,698,000 | -142,321,000 | -148,988,000 | -83,525,000 | -140,474,000 | -131,644,000 | -99,446,000 | -144,931,000 | -143,687,000 | -59,014,000 | -419,000 | -9,299,000 | -6,548,000 | -724,000 | -480,000 | -322,000 | ||||||||||||||||||||||
accumulated deficit | -8,092,546,000 | -8,319,903,000 | -8,386,405,000 | -8,511,246,000 | -8,605,566,000 | -8,606,836,000 | -8,454,955,000 | -8,333,605,000 | -8,213,200,000 | -7,962,050,000 | -7,594,497,000 | -7,809,910,000 | -7,428,773,000 | -7,080,342,000 | -6,635,007,000 | -5,971,826,000 | -5,400,377,000 | -4,966,103,000 | -4,380,450,000 | -3,966,595,000 | -3,486,254,000 | -3,552,749,000 | -3,080,004,000 | -2,654,780,000 | -2,319,578,000 | -1,955,843,000 | -1,567,782,000 | -1,260,425,000 | -1,174,855,000 | -1,007,215,000 | -738,960,000 | -594,929,000 | -438,042,000 | -330,517,000 | -231,194,000 | -348,580,000 | |||||
total shareholders’ equity | 4,760,442,000 | 4,361,194,000 | 4,129,326,000 | 3,770,475,000 | 3,499,513,000 | 3,332,222,000 | 3,436,073,000 | 3,366,255,000 | 3,360,361,000 | 3,537,327,000 | 308,417,000 | ||||||||||||||||||||||||||||||
total liabilities and shareholders’ equity | 8,553,619,000 | 8,188,573,000 | 7,632,586,000 | 6,298,394,000 | 5,841,526,000 | 5,920,910,000 | 5,830,860,000 | 5,712,179,000 | 5,667,681,000 | 5,805,275,000 | 376,729,000 | ||||||||||||||||||||||||||||||
research and development cost share liability, non-current portion | 10,879,000 | 34,501,000 | 54,286,000 | 82,985,000 | 119,012,000 | 143,544,000 | 170,662,000 | 191,739,000 | 208,775,000 | 207,052,000 | 179,625,000 | 204,252,000 | 219,385,000 | 247,572,000 | 269,561,000 | 266,163,000 | 303,126,000 | 340,585,000 | 375,040,000 | 384,151,000 | 424,890,000 | 460,528,000 | |||||||||||||||||||
long-term bank loans | 187,513,000 | 185,271,000 | 199,027,000 | 202,491,000 | 207,426,000 | 206,298,000 | 208,058,000 | 185,207,000 | 201,605,000 | 200,906,000 | 194,856,000 | 193,017,000 | 183,637,000 | ||||||||||||||||||||||||||||
short-term investments | 2,600,000 | 106,989,000 | 105,693,000 | 294,057,000 | 665,251,000 | 871,998,000 | 1,172,554,000 | 1,897,783,000 | 2,241,962,000 | 2,533,617,000 | 2,605,452,000 | 2,910,472,000 | 3,268,725,000 | 3,254,300,000 | 1,807,744,000 | 1,417,097,000 | 364,728,000 | 375,768,000 | 618,803,000 | 849,167,000 | 1,068,509,000 | 1,390,276,000 | 931,208,000 | 973,381,000 | 597,914,000 | 548,925,000 | 146,424,000 | 229,726,000 | 118,086,000 | 168,535,000 | 38,720,000 | ||||||||||
short-term restricted cash | 11,473,000 | 11,548,000 | 9,693,000 | 159,000 | 196,000 | 191,000 | 333,000 | 330,000 | 328,000 | 330,000 | 310,000 | 305,000 | 307,000 | 295,000 | 283,000 | 282,000 | 288,000 | 14,271,000 | 14,567,000 | 14,900,000 | 14,544,000 | ||||||||||||||||||||
deferred revenue, current portion | 159,034,000 | 185,477,000 | 213,861,000 | 144,984,000 | 163,396,000 | 163,658,000 | 187,414,000 | 72,626,000 | 63,605,000 | 71,651,000 | 17,504,000 | 18,140,000 | 15,302,000 | 14,011,000 | 12,233,000 | 9,132,000 | |||||||||||||||||||||||||
deferred revenue, non-current portion | 300,000 | 300,000 | 24,276,000 | 37,345,000 | 42,026,000 | 149,899,000 | 167,570,000 | 204,369,000 | 220,289,000 | 52,272,000 | 75,272,000 | 78,594,000 | 8,240,000 | 9,842,000 | 18,297,000 | 21,291,000 | 24,808,000 | 29,477,000 | |||||||||||||||||||||||
liabilities and shareholders' equity | |||||||||||||||||||||||||||||||||||||||||
shareholders' equity: | |||||||||||||||||||||||||||||||||||||||||
ordinary shares, us0.0001 par value per share... | 135,000 | 137,000 | 136,000 | 135,000 | 134,000 | 133,000 | 121,000 | 120,000 | 119,000 | 118,000 | 102,000 | 101,000 | 78,000 | 78,000 | 78,000 | 77,000 | |||||||||||||||||||||||||
total shareholders' equity | 3,763,234,000 | ||||||||||||||||||||||||||||||||||||||||
total liabilities and shareholders' equity | 5,524,879,000 | ||||||||||||||||||||||||||||||||||||||||
long-term restricted cash | 1,513,000 | 4,963,000 | 5,277,000 | 3,189,000 | 3,939,000 | 6,958,000 | 6,881,000 | 6,056,000 | 9,927,000 | 8,282,000 | 7,748,000 | 4,950,000 | 4,602,000 | 2,435,000 | 2,476,000 | 30,401,000 | 9,161,000 | 8,991,000 | 13,232,000 | ||||||||||||||||||||||
equity: | |||||||||||||||||||||||||||||||||||||||||
total equity | 3,798,559,000 | 4,157,306,000 | 4,383,355,000 | 4,655,171,000 | 5,302,544,000 | 5,885,500,000 | 6,242,987,000 | 3,357,073,000 | 3,606,775,000 | 4,003,587,000 | 3,869,243,000 | 4,296,514,000 | 2,546,492,000 | 2,827,056,000 | 978,355,000 | 1,294,237,000 | 1,571,264,000 | 1,622,679,000 | 1,753,647,000 | 1,983,431,000 | 1,226,668,000 | 1,358,722,000 | 684,231,000 | 764,489,000 | 270,172,000 | ||||||||||||||||
total liabilities and equity | 5,728,736,000 | 5,956,775,000 | 6,379,290,000 | 6,726,013,000 | 7,378,207,000 | 8,021,388,000 | 8,645,949,000 | 5,286,334,000 | 5,524,116,000 | 5,821,004,000 | 5,600,757,000 | 5,566,390,000 | 3,903,290,000 | 4,067,212,000 | 1,612,289,000 | 1,881,070,000 | 2,150,318,000 | 2,172,232,000 | 2,249,684,000 | 2,408,627,000 | 1,653,856,000 | 1,708,927,000 | 1,046,479,000 | 1,049,059,000 | 473,975,000 | ||||||||||||||||
accumulated other comprehensive income | -77,417,000 | -161,523,000 | -82,450,000 | 17,454,000 | 17,950,000 | 12,580,000 | 12,095,000 | 3,204,000 | 6,942,000 | -8,001,000 | -14,830,000 | -225,000 | 6,072,000 | 1,526,000 | 3,114,000 | 320,000 | 38,000 | ||||||||||||||||||||||||
deferred tax assets | 103,429,000 | 115,760,000 | 110,424,000 | 106,844,000 | 79,751,000 | 78,215,000 | 65,962,000 | 48,009,000 | 39,801,000 | 37,937,000 | 37,894,000 | 42,146,000 | 31,389,000 | 30,526,000 | 29,542,000 | 16,474,000 | 16,071,000 | 11,991,000 | 7,675,000 | 7,684,000 | 4,827,000 | 2,928,000 | |||||||||||||||||||
shareholder loan | 160,164,000 | 157,278,000 | 157,384,000 | 150,758,000 | 154,321,000 | 155,174,000 | 148,888,000 | 146,409,000 | 149,217,000 | 154,551,000 | 146,271,000 | 140,311,000 | 135,027,000 | ||||||||||||||||||||||||||||
total beigene, ltd. shareholders’ equity | 3,869,243,000 | 4,287,494,000 | 2,536,298,000 | 2,812,214,000 | 962,205,000 | 1,278,478,000 | 1,553,877,000 | 1,608,769,000 | 1,739,202,000 | 1,970,446,000 | 1,213,197,000 | 1,344,381,000 | 669,809,000 | 750,140,000 | 255,753,000 | ||||||||||||||||||||||||||
noncontrolling interest | 9,020,000 | 10,194,000 | 14,842,000 | 16,150,000 | 15,759,000 | 17,387,000 | 13,910,000 | 14,445,000 | 12,985,000 | 13,471,000 | 14,341,000 | 14,422,000 | 14,349,000 | 14,419,000 | |||||||||||||||||||||||||||
short-term bank loans | 26,061,000 | ||||||||||||||||||||||||||||||||||||||||
long-term bank loan | 131,491,000 | 81,913,000 | 104,233,000 | 84,489,000 | 77,480,000 | 40,785,000 | 40,824,000 | 51,467,000 | 9,565,000 | 9,222,000 | 9,018,000 | 17,701,000 | 17,434,000 | 18,030,000 | 10,553,000 | 6,214,000 | |||||||||||||||||||||||||
short-term bank loan | 11,298,000 | ||||||||||||||||||||||||||||||||||||||||
property and equipment | 242,402,000 | 157,061,000 | 111,262,000 | 90,510,000 | 76,990,000 | 62,568,000 | 55,322,000 | 33,770,000 | 30,723,000 | 16,554,000 | 9,752,000 | 7,702,000 | |||||||||||||||||||||||||||||
land use right | 45,058,000 | 11,629,000 | 12,132,000 | 12,863,000 | 12,465,000 | 12,251,000 | |||||||||||||||||||||||||||||||||||
long-term bank loans, current portion | |||||||||||||||||||||||||||||||||||||||||
long-term bank loans, non-current portion | 83,311,000 | ||||||||||||||||||||||||||||||||||||||||
unbilled receivable | 6,114,000 | 8,612,000 | 4,878,000 | 12,702,000 | 23,862,000 | 170,950,000 | |||||||||||||||||||||||||||||||||||
goodwill | 109,000 | 109,000 | 109,000 | 109,000 | 109,000 | 109,000 | 109,000 | 109,000 | 1,984,000 | ||||||||||||||||||||||||||||||||
current portion of operating lease liabilities | 10,671,000 | 9,167,000 | 9,451,000 | ||||||||||||||||||||||||||||||||||||||
current portion of long-term bank loan | 700,000 | 8,740,000 | 8,940,000 | 8,727,000 | 8,736,000 | 9,067,000 | 9,565,000 | 9,222,000 | 9,018,000 | ||||||||||||||||||||||||||||||||
operating lease liabilities | 18,847,000 | 18,662,000 | 19,545,000 | ||||||||||||||||||||||||||||||||||||||
restricted cash, current | 14,560,000 | ||||||||||||||||||||||||||||||||||||||||
restricted cash, non-current | 52,751,000 | ||||||||||||||||||||||||||||||||||||||||
deferred revenue, current | 16,705,000 | ||||||||||||||||||||||||||||||||||||||||
deferred revenue, non-current | 14,660,000 | ||||||||||||||||||||||||||||||||||||||||
restricted cash | 31,591,000 | 17,460,000 | |||||||||||||||||||||||||||||||||||||||
ordinary shares | 70,000 | 70,000 | 59,000 | 59,000 | 52,000 | 52,000 | 43,000 | 43,000 | 43,000 | 32,000 | |||||||||||||||||||||||||||||||
short-term loan | 2,470,000 | ||||||||||||||||||||||||||||||||||||||||
liabilities and shareholders’ deficit | |||||||||||||||||||||||||||||||||||||||||
advances from customers | 393,000 | ||||||||||||||||||||||||||||||||||||||||
senior promissory note | |||||||||||||||||||||||||||||||||||||||||
warrant and option liabilities | |||||||||||||||||||||||||||||||||||||||||
deferred rental | |||||||||||||||||||||||||||||||||||||||||
convertible preferred shares | |||||||||||||||||||||||||||||||||||||||||
series a | |||||||||||||||||||||||||||||||||||||||||
total mezzanine equity | |||||||||||||||||||||||||||||||||||||||||
shareholders’ deficit: | |||||||||||||||||||||||||||||||||||||||||
total shareholders’ (deficit) equity | 187,832,000 | 220,047,000 | 243,099,000 | 88,917,000 | |||||||||||||||||||||||||||||||||||||
total liabilities, mezzanine equity and shareholders’ (deficit) equity | 235,425,000 | 251,230,000 | 265,228,000 | 116,764,000 |
Cashflow Statements:
Quarterly
Annual
| Unit: USD | 2026-03-31 | 2025-12-31 | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2017-12-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | 2016-09-30 | 2016-06-30 | 2016-03-31 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
operating activities: | ||||||||||||||||||||||||||||||||||||||||
net income | 227,357,000 | 66,502,000 | 124,841,000 | 94,320,000 | 1,270,000 | -434,274,000 | 66,495,000 | |||||||||||||||||||||||||||||||||
adjustments to reconcile net income to net cash from operating activities: | ||||||||||||||||||||||||||||||||||||||||
depreciation and amortization expense | 41,144,000 | 35,984,000 | 37,284,000 | 35,614,000 | 32,804,000 | 50,246,000 | 71,292,000 | 24,931,000 | 25,293,000 | 23,819,000 | 21,510,000 | 22,335,000 | 20,011,000 | 18,016,000 | 16,201,000 | 15,461,000 | 16,600,000 | 13,121,000 | 12,177,000 | 11,527,000 | 9,632,000 | 7,828,000 | 8,344,000 | 7,867,000 | 7,750,000 | 7,484,000 | 4,022,000 | 3,695,000 | 3,416,000 | 3,363,000 | 2,445,000 | 2,336,000 | 2,244,000 | 2,054,000 | ||||||
share-based compensation expenses | 123,355,000 | 140,809,000 | 150,809,000 | 95,478,000 | 114,697,000 | 130,637,000 | 88,667,000 | 96,004,000 | 103,371,000 | 75,322,000 | 78,176,000 | 81,305,000 | 65,555,000 | 67,077,000 | 64,791,000 | 45,833,000 | 50,297,000 | 45,468,000 | 38,255,000 | 36,818,000 | 32,602,000 | 26,392,000 | 25,958,000 | 25,132,000 | 18,641,000 | 17,396,000 | 2,779,000 | 1,285,000 | 2,614,000 | |||||||||||
amortization of research and development cost share liability | -28,645,000 | -26,251,000 | -29,275,000 | -25,757,000 | -19,812,000 | -21,612,000 | -16,575,000 | -21,903,000 | -13,136,000 | -16,725,000 | -15,900,000 | -5,271,000 | -17,398,000 | -26,013,000 | -24,806,000 | -23,764,000 | -21,819,000 | -29,640,000 | -28,944,000 | -26,972,000 | -26,930,000 | -28,690,000 | -30,056,000 | -27,606,000 | -27,634,000 | |||||||||||||||
non-cash interest expense | 21,096,000 | 2,534,000 | 2,572,000 | 2,570,000 | 1,717,000 | 1,901,000 | 1,858,000 | 1,856,000 | 1,849,000 | 2,103,000 | 2,012,000 | 2,239,000 | 2,564,000 | |||||||||||||||||||||||||||
other items | 6,172,000 | -12,548,000 | -5,533,000 | 2,759,000 | 12,369,000 | -353,000 | 6,103,000 | 4,565,000 | 848,000 | -6,820,000 | 55,000 | 192,000 | 575,000 | 1,285,000 | 1,402,000 | 2,816,000 | 3,544,000 | 5,791,000 | 6,507,000 | 5,949,000 | 5,263,000 | 5,490,000 | 2,007,000 | 242,000 | -1,105,000 | |||||||||||||||
changes in operating assets and liabilities: | ||||||||||||||||||||||||||||||||||||||||
accounts receivable | -75,300,000 | 2,340,000 | -93,925,000 | -41,503,000 | -31,866,000 | -125,699,000 | -29,848,000 | -93,871,000 | -80,025,000 | -44,795,000 | -11,588,000 | 4,564,000 | -136,487,000 | 19,395,000 | -22,713,000 | 14,876,000 | 292,554,000 | -353,845,000 | -55,836,000 | 10,318,000 | -23,656,000 | -134,000 | 1,403,000 | 5,858,000 | 3,236,000 | -14,966,000 | 2,196,000 | 868,000 | -17,920,000 | -3,684,000 | -4,201,000 | -9,686,000 | 5,943,000 | -18,907,000 | ||||||
inventories | -71,838,000 | -70,506,000 | -28,836,000 | 2,187,000 | 3,987,000 | -79,384,000 | 23,837,000 | 1,315,000 | -37,264,000 | -88,577,000 | 1,227,000 | -40,571,000 | -13,027,000 | 18,943,000 | -43,999,000 | -28,631,000 | -3,002,000 | -91,647,000 | -33,392,000 | -44,613,000 | 16,319,000 | -51,934,000 | -2,291,000 | -4,459,000 | -222,000 | 8,959,000 | 11,536,000 | -35,908,000 | 3,102,000 | 3,457,000 | -13,377,000 | 1,176,000 | 3,432,000 | -5,218,000 | ||||||
other assets | 15,270,000 | -18,083,000 | 100,563,000 | -75,053,000 | 29,737,000 | 35,621,000 | 41,738,000 | -27,832,000 | -4,401,000 | 29,718,000 | 13,029,000 | 19,781,000 | -50,408,000 | -33,607,000 | -1,990,000 | 49,268,000 | -16,953,000 | -14,190,000 | -15,734,000 | |||||||||||||||||||||
accounts payable | -42,187,000 | 87,214,000 | 28,471,000 | -4,284,000 | -31,568,000 | 107,961,000 | 11,344,000 | -44,108,000 | 46,300,000 | -9,882,000 | 64,044,000 | -10,089,000 | -22,589,000 | -8,555,000 | 34,565,000 | 4,662,000 | -35,024,000 | 32,384,000 | 30,182,000 | 30,620,000 | -73,178,000 | 73,856,000 | -12,872,000 | 56,301,000 | -21,450,000 | 10,375,000 | -29,582,000 | 41,795,000 | -20,364,000 | 17,893,000 | -4,731,000 | 28,795,000 | -18,487,000 | 33,878,000 | 8,178,000 | 4,768,000 | 8,474,000 | |||
accrued expenses and other payables | -16,819,000 | 145,876,000 | 90,261,000 | 127,985,000 | -52,360,000 | 56,716,000 | 82,894,000 | 51,053,000 | -79,309,000 | 130,022,000 | 58,171,000 | 30,599,000 | -38,681,000 | 43,999,000 | -17,897,000 | 93,567,000 | -74,042,000 | 139,225,000 | -869,000 | 35,698,000 | -34,010,000 | 66,821,000 | 71,401,000 | 28,696,000 | 15,775,000 | 30,536,000 | 29,959,000 | 12,325,000 | -8,790,000 | 24,259,000 | 845,000 | 19,324,000 | 6,115,000 | 2,607,000 | 22,241,000 | -2,036,000 | 2,166,000 | 7,489,000 | 2,649,000 | 3,222,000 |
other liabilities | 1,731,000 | 15,418,000 | 3,486,000 | -3,979,000 | 4,043,000 | -14,233,000 | 241,000 | -186,000 | -660,000 | 532,000 | -33,000 | -109,000 | 197,000 | -1,376,000 | 2,281,000 | -400,000 | -1,714,000 | -6,058,000 | 249,000 | |||||||||||||||||||||
net cash from operating activities | 201,336,000 | 417,347,000 | 402,553,000 | 263,598,000 | 44,082,000 | 75,160,000 | 188,369,000 | -95,588,000 | -308,572,000 | -221,638,000 | -78,150,000 | -293,888,000 | -563,777,000 | -318,191,000 | -561,906,000 | -379,959,000 | -236,563,000 | -507,839,000 | -495,713,000 | -420,266,000 | 125,095,000 | -332,334,000 | -346,241,000 | -262,942,000 | -341,944,000 | -267,181,000 | -265,012,000 | -46,101,000 | -171,975,000 | -193,894,000 | -132,185,000 | -117,137,000 | -104,501,000 | 93,749,000 | 6,600,000 | |||||
capital expenditures | -40,789,000 | 0 | -48,084,000 | -43,826,000 | -56,407,000 | 0 | -133,655,000 | -109,950,000 | -156,578,000 | 0 | -157,882,000 | -121,470,000 | -125,585,000 | 0 | -108,655,000 | -50,290,000 | -45,131,000 | 0 | -67,043,000 | -38,531,000 | -42,389,000 | 0 | -28,681,000 | -32,605,000 | -21,533,000 | 0 | -30,873,000 | -21,447,000 | -21,828,000 | -23,254,000 | -26,720,000 | -10,613,000 | -9,696,000 | -18,933,000 | -18,560,000 | |||||
free cash flows | 160,547,000 | 417,347,000 | 354,469,000 | 219,772,000 | -12,325,000 | 75,160,000 | 54,714,000 | -205,538,000 | -465,150,000 | -221,638,000 | -236,032,000 | -415,358,000 | -689,362,000 | -318,191,000 | -670,561,000 | -430,249,000 | -281,694,000 | -507,839,000 | -562,756,000 | -458,797,000 | 82,706,000 | -332,334,000 | -374,922,000 | -295,547,000 | -363,477,000 | -267,181,000 | -295,885,000 | -67,548,000 | -193,803,000 | -217,148,000 | -158,905,000 | -127,750,000 | -114,197,000 | 74,816,000 | -11,960,000 | |||||
investing activities: | ||||||||||||||||||||||||||||||||||||||||
purchases of property, plant and equipment | -40,789,000 | -48,084,000 | -43,826,000 | -56,407,000 | -133,655,000 | -109,950,000 | -156,578,000 | -157,882,000 | -121,470,000 | -125,585,000 | -108,655,000 | -50,290,000 | -45,131,000 | -67,043,000 | -38,531,000 | -42,389,000 | -28,681,000 | -32,605,000 | -21,533,000 | -30,873,000 | -21,447,000 | -21,828,000 | ||||||||||||||||||
proceeds from sale or maturity of investments | 27,000 | 0 | 0 | 1,800,000 | 0 | 0 | 2,655,000 | 19,000 | 190,538,000 | 376,962,000 | 301,370,000 | 720,000,000 | 331,028,000 | 760,876,000 | 890,515,000 | 1,107,000,000 | 778,467,000 | 975,366,000 | 740,499,000 | 256,743,000 | 384,537,000 | 456,893,000 | 710,598,000 | |||||||||||||||||
purchase of in-process research and development | 0 | -691,000 | 0 | -60,000,000 | 0 | 0 | 0 | -31,800,000 | 0 | -48,665,000 | -20,000,000 | 0 | -75,000,000 | 0 | 0 | 0 | -8,500,000 | -20,000,000 | -46,500,000 | 0 | -43,000,000 | -20,000,000 | 0 | -20,000,000 | -29,000,000 | -60,000,000 | 0 | 0 | -10,000,000 | |||||||||||
other investing activities | -4,748,000 | 9,375,000 | -499,000 | -2,779,000 | -7,334,000 | 17,881,000 | -227,000 | -1,082,000 | -19,434,000 | -9,250,000 | 0 | |||||||||||||||||||||||||||||
net cash from investing activities | -45,510,000 | -38,335,000 | -49,274,000 | -66,605,000 | -121,941,000 | -93,605,000 | -133,882,000 | -111,032,000 | -209,831,000 | -62,584,000 | -186,275,000 | 67,800,000 | 241,063,000 | 38,536,000 | 169,484,000 | 658,710,000 | 210,393,000 | 109,110,000 | -11,995,000 | 251,596,000 | 291,948,000 | -86,925,000 | -1,536,577,000 | -429,895,000 | -1,114,969,000 | -23,892,000 | 213,630,000 | 192,009,000 | 172,416,000 | 213,243,000 | -394,352,000 | -68,242,000 | -401,326,000 | |||||||
financing activities: | ||||||||||||||||||||||||||||||||||||||||
repayment of long-term loan | -7,641,000 | -14,618,000 | -4,263,000 | -12,584,000 | -4,215,000 | -10,450,000 | -3,561,000 | -10,441,000 | -3,579,000 | -5,228,000 | -1,457,000 | 0 | ||||||||||||||||||||||||||||
proceeds from short-term loans | 58,204,000 | 12,155,000 | 0 | 141,521,000 | 80,000,000 | 543,858,000 | 0 | 182,384,000 | 142,028,000 | 498,916,000 | 768,000 | 150,000,000 | 96,188,000 | 17,586,000 | 50,000,000 | 262,993,000 | 30,867,000 | 41,588,000 | 71,001,000 | |||||||||||||||||||||
repayment of short-term loans | -768,999,000 | 0 | -102,861,000 | -172,921,000 | -546,726,000 | 0 | -150,000,000 | -93,002,000 | -16,574,000 | -50,000,000 | -271,653,000 | -30,023,000 | -42,258,000 | -73,147,000 | -281,525,000 | |||||||||||||||||||||||||
repayment of sale of future royalties liability | -2,557,000 | |||||||||||||||||||||||||||||||||||||||
proceeds from option exercises and employee share purchase plan | 23,875,000 | 19,243,000 | 80,535,000 | 33,144,000 | 63,359,000 | 8,795,000 | 16,223,000 | 5,564,000 | 14,791,000 | 3,360,000 | 17,183,000 | 3,580,000 | 31,589,000 | 11,287,000 | 16,705,000 | 7,092,000 | 11,880,000 | 10,570,000 | 46,591,000 | 9,847,000 | 25,754,000 | 17,271,000 | 47,632,000 | 16,569,000 | 11,629,000 | 26,617,000 | 9,745,000 | 4,373,000 | 6,269,000 | |||||||||||
other financing activities | -3,249,000 | 0 | 0 | |||||||||||||||||||||||||||||||||||||
net cash from financing activities | 68,632,000 | 96,931,000 | 961,272,000 | 35,025,000 | -33,777,000 | -4,523,000 | 12,662,000 | 23,017,000 | 162,293,000 | 347,048,000 | -76,782,000 | 166,080,000 | -19,868,000 | -110,366,000 | 120,242,000 | -17,580,000 | -11,267,000 | 3,384,654,000 | 109,207,000 | 35,631,000 | 107,419,000 | 325,658,000 | 1,994,007,000 | 80,993,000 | 2,802,168,000 | 2,198,000 | 25,136,000 | 15,382,000 | 42,964,000 | 8,803,000 | 871,250,000 | 46,583,000 | 763,901,000 | 3,048,000 | 339,708,000 | |||||
effect of foreign exchange rate changes | 19,320,000 | 23,162,000 | 9,905,000 | 23,477,000 | 3,480,000 | -51,713,000 | 28,348,000 | -5,902,000 | -22,438,000 | 42,266,000 | 525,000 | -62,184,000 | 11,311,000 | 64,546,000 | -62,717,000 | -80,212,000 | 9,000,000 | 7,266,000 | 1,512,000 | 9,318,000 | -4,061,000 | 13,891,000 | 8,627,000 | 1,925,000 | -6,212,000 | 8,827,000 | -15,607,000 | -6,997,000 | 4,265,000 | 1,765,000 | -7,644,000 | -1,661,000 | 3,444,000 | 2,537,000 | 2,522,000 | 86,000 | ||||
net increase in cash, cash equivalents, and restricted cash | 243,778,000 | 499,105,000 | 1,324,456,000 | 180,959,000 | -28,437,000 | 2,993,191,000 | -396,989,000 | -123,721,000 | 520,401,000 | -79,710,000 | 119,816,000 | -609,919,000 | 1,339,043,000 | -280,048,000 | -41,853,000 | 154,293,000 | 47,670,000 | 29,917,000 | 240,785,000 | -38,083,000 | 268,492,000 | |||||||||||||||||||
cash, cash equivalents, and restricted cash at beginning of period | 4,609,647,000 | 0 | 0 | 2,638,747,000 | 0 | 0 | 3,185,984,000 | 0 | 0 | 3,875,037,000 | 0 | 0 | 4,382,887,000 | 0 | 0 | 1,390,005,000 | 0 | 0 | 620,775,000 | 0 | 0 | 740,713,000 | 0 | |||||||||||||||||
cash, cash equivalents, and restricted cash at end of period | 4,853,425,000 | 1,324,456,000 | 255,495,000 | 2,530,591,000 | 95,497,000 | -189,505,000 | 2,807,436,000 | -340,682,000 | -122,192,000 | 3,543,766,000 | -334,897,000 | 180,959,000 | 4,354,450,000 | -396,989,000 | -123,721,000 | 1,910,406,000 | 119,816,000 | -609,919,000 | 1,959,818,000 | -41,853,000 | 154,293,000 | 788,383,000 | 240,785,000 | |||||||||||||||||
supplemental cash flow information: | ||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents | 4,791,676,000 | 510,662,000 | 1,280,812,000 | 239,645,000 | 2,516,411,000 | -74,523,000 | 109,278,000 | -200,715,000 | 2,793,370,000 | 104,464,000 | -343,032,000 | -128,276,000 | 3,538,644,000 | -327,568,000 | -334,005,000 | 183,975,000 | 4,347,162,000 | 2,992,368,000 | -393,138,000 | -125,371,000 | 1,901,819,000 | 119,456,000 | -612,087,000 | 1,957,101,000 | -62,797,000 | 154,456,000 | 764,492,000 | 205,065,000 | -52,214,000 | 490,634,000 | ||||||||||
short-term restricted cash | 40,839,000 | -11,703,000 | 37,185,000 | 4,469,000 | 11,333,000 | 28,000 | -13,871,000 | 11,710,000 | 11,445,000 | -75,000 | 1,855,000 | 9,534,000 | 159,000 | 5,000 | -142,000 | 3,000 | 330,000 | -2,000 | 20,000 | 5,000 | 305,000 | 12,000 | 1,000 | 282,000 | ||||||||||||||||
long-term restricted cash | 20,910,000 | 146,000 | 6,459,000 | 11,381,000 | 2,847,000 | -186,000 | 90,000 | -500,000 | 2,621,000 | 703,000 | 495,000 | -3,450,000 | 4,963,000 | 2,088,000 | -750,000 | -3,019,000 | 6,958,000 | 825,000 | -3,871,000 | 1,645,000 | 8,282,000 | 348,000 | 2,167,000 | 2,435,000 | ||||||||||||||||
income taxes (refunded)/paid | -2,737,000 | |||||||||||||||||||||||||||||||||||||||
interest expense paid | 12,834,000 | 12,130,000 | 11,812,000 | 12,206,000 | 14,014,000 | 12,708,000 | 11,440,000 | 1,202,000 | 888,000 | 879,000 | 336,000 | 331,000 | 320,000 | 322,000 | 313,000 | 305,000 | 268,000 | 134,000 | 108,000 | |||||||||||||||||||||
supplemental non-cash information: | ||||||||||||||||||||||||||||||||||||||||
capital expenditures included in accounts payable and accrued expenses | 43,249,000 | -5,866,000 | -2,087,000 | 60,010,000 | -40,247,000 | 15,091,000 | 100,473,000 | 12,207,000 | 31,391,000 | 64,013,000 | ||||||||||||||||||||||||||||||
rou assets obtained in exchange for new operating lease liabilities | 9,261,000 | 986,000 | 2,482,000 | 15,659,000 | ||||||||||||||||||||||||||||||||||||
cash flows from operating activities: | ||||||||||||||||||||||||||||||||||||||||
share-based compensation expense | 13,327,000 | 7,082,000 | 5,992,000 | |||||||||||||||||||||||||||||||||||||
acquired in-process research and development | 0 | 191,000 | 31,800,000 | 48,665,000 | 30,000,000 | 0 | 45,000,000 | 8,500,000 | 20,000,000 | 46,500,000 | 0 | 43,000,000 | 20,000,000 | 0 | 20,000,000 | 29,000,000 | 60,000,000 | 0 | 0 | 10,000,000 | ||||||||||||||||||||
impairment of equity investments | 41,410,000 | |||||||||||||||||||||||||||||||||||||||
loss on long-term investments | ||||||||||||||||||||||||||||||||||||||||
deferred income tax expense | ||||||||||||||||||||||||||||||||||||||||
gain on bms termination settlement | 0 | |||||||||||||||||||||||||||||||||||||||
deferred revenue | 156,000 | 261,000 | 0 | -183,010,000 | -39,511,000 | -33,066,000 | -38,996,000 | -36,083,000 | -37,061,000 | -39,676,000 | 282,805,000 | -13,979,000 | -11,368,000 | 150,245,000 | 0 | 0 | -25,744,000 | -2,238,000 | -3,383,000 | -2,234,000 | -1,703,000 | -1,739,000 | -1,568,000 | |||||||||||||||||
cash flows from investing activities: | ||||||||||||||||||||||||||||||||||||||||
purchases of property and equipment | -23,254,000 | -26,720,000 | -10,613,000 | -9,696,000 | -18,933,000 | -18,560,000 | ||||||||||||||||||||||||||||||||||
purchase of intangible assets | -332,000 | |||||||||||||||||||||||||||||||||||||||
purchase of long-term investments | ||||||||||||||||||||||||||||||||||||||||
proceeds from sale or maturity of short-term investments | ||||||||||||||||||||||||||||||||||||||||
cash flows from financing activities: | ||||||||||||||||||||||||||||||||||||||||
proceeds from sale of future royalties | 26,000,000 | |||||||||||||||||||||||||||||||||||||||
proceeds from long-term loan | 0 | 0 | 0 | 9,053,000 | 0 | 6,731,000 | 0 | 0 | 6,019,000 | 155,000 | 10,664,000 | 7,009,000 | 36,695,000 | 0 | 0 | 7,640,000 | ||||||||||||||||||||||||
payments of debt issuance costs | ||||||||||||||||||||||||||||||||||||||||
payments of withholding taxes from share-based awards | 0 | 0 | ||||||||||||||||||||||||||||||||||||||
cash, cash equivalents, and restricted cash, beginning of year | ||||||||||||||||||||||||||||||||||||||||
cash, cash equivalents, and restricted cash, end of year | ||||||||||||||||||||||||||||||||||||||||
supplemental cash flow disclosures: | ||||||||||||||||||||||||||||||||||||||||
interest paid | 4,998,000 | 5,017,000 | 5,304,000 | 6,966,000 | 6,282,000 | 6,617,000 | 6,569,000 | 9,131,000 | 7,340,000 | 6,927,000 | 38,223,000 | 2,218,000 | 1,136,000 | |||||||||||||||||||||||||||
supplemental non-cash activities: | ||||||||||||||||||||||||||||||||||||||||
accruals for capital expenditures | ||||||||||||||||||||||||||||||||||||||||
purchase of in-process research and development included in accounts payable | ||||||||||||||||||||||||||||||||||||||||
purchase of intangible asset | 0 | 0 | 0 | -4,674,000 | ||||||||||||||||||||||||||||||||||||
income taxes paid | 2,929,000 | 67,712,000 | 9,321,000 | 14,652,000 | 9,142,000 | 43,146,000 | 2,490,000 | 13,487,000 | 9,987,000 | 24,913,000 | 7,616,000 | 4,494,000 | 570,000 | 23,700,000 | 736,000 | 481,000 | 687,000 | 14,049,000 | 478,000 | 1,346,000 | 8,719,000 | 531,000 | 1,077,000 | 7,514,000 | 360,000 | 309,000 | 11,513,000 | 329,000 | 27,857,000 | 683,000 | 670,000 | 76,000 | 0 | 0 | 25,000 | |||||
increase in equity investment from deconsolidation of a subsidiary | 0 | 0 | 40,798,000 | |||||||||||||||||||||||||||||||||||||
gain on deconsolidation of a subsidiary | 0 | -3,735,000 | 0 | |||||||||||||||||||||||||||||||||||||
net decrease in cash, cash equivalents, and restricted cash | -108,156,000 | -74,681,000 | 95,497,000 | -189,505,000 | -378,548,000 | -340,682,000 | -122,192,000 | -331,271,000 | ||||||||||||||||||||||||||||||||
net loss | -151,881,000 | -121,350,000 | -120,405,000 | -251,150,000 | -367,553,000 | 215,413,000 | -381,137,000 | -348,431,000 | -445,335,000 | -552,757,000 | -585,653,000 | -413,855,000 | -472,649,000 | -426,617,000 | -336,318,000 | -364,939,000 | -387,895,000 | -308,660,000 | -85,954,000 | -168,069,000 | -157,715,000 | -105,116,000 | ||||||||||||||||||
adjustments to reconcile net loss to net cash from operating activities: | ||||||||||||||||||||||||||||||||||||||||
unrealized losses on long-term investments | ||||||||||||||||||||||||||||||||||||||||
acquired intangible asset included in accounts payable | ||||||||||||||||||||||||||||||||||||||||
purchases of short-term investments | ||||||||||||||||||||||||||||||||||||||||
proceeds from public offering, net of cost | ||||||||||||||||||||||||||||||||||||||||
proceeds from sale of ordinary shares, net of cost | 0 | 0 | 2,069,610,000 | 0 | 2,162,407,000 | 0 | ||||||||||||||||||||||||||||||||||
unrealized losses on equity investments | 10,095,000 | 2,009,000 | 169,000 | 5,583,000 | -7,116,000 | 6,555,000 | 16,974,000 | |||||||||||||||||||||||||||||||||
deferred income tax benefits | 750,000 | -51,000 | 36,000 | -7,170,000 | 12,836,000 | -5,286,000 | -2,677,000 | -26,097,000 | -60,000 | -12,251,000 | -19,045,000 | -7,702,000 | -854,000 | -206,000 | 4,102,000 | -11,878,000 | -473,000 | -983,000 | -13,150,000 | -386,000 | -4,323,000 | -4,090,000 | 26,000 | -1,812,000 | ||||||||||||||||
purchases of investments | -3,999,000 | -10,518,000 | -1,064,000 | -3,231,000 | -11,000,000 | -504,000 | -705,828,000 | -592,888,000 | -764,163,000 | -810,703,000 | -2,436,762,000 | -1,135,764,000 | -1,307,179,000 | -318,475,000 | -140,034,000 | -223,437,000 | -487,354,000 | -519,176,000 | -917,588,000 | -566,698,000 | -632,224,000 | |||||||||||||||||||
proceeds from research and development cost share liability | 0 | 0 | 0 | 616,834,000 | ||||||||||||||||||||||||||||||||||||
payment to acquire joint venture (jv) minority interest | ||||||||||||||||||||||||||||||||||||||||
acquisitions of equipment included in accounts payable | -11,366,000 | -4,060,000 | 62,736,000 | 11,300,000 | 13,012,000 | -2,021,000 | 30,906,000 | 1,964,000 | 2,550,000 | 26,412,000 | -6,672,000 | 3,465,000 | 32,462,000 | 4,014,000 | 4,366,000 | 3,640,000 | 733,000 | 109,000 | -831,000 | 2,204,000 | 241,000 | -13,000 | 91,000 | |||||||||||||||||
acquired in-process research and development included in accrued expenses | 0 | |||||||||||||||||||||||||||||||||||||||
unrealized gains on equity investments | 9,534,000 | |||||||||||||||||||||||||||||||||||||||
capital contribution from noncontrolling interest | 0 | 0 | 0 | 0 | ||||||||||||||||||||||||||||||||||||
prepayment to acquire joint venture ("jv") minority interest | ||||||||||||||||||||||||||||||||||||||||
repayment of short-term loan | 0 | 0 | ||||||||||||||||||||||||||||||||||||||
unrealized gains on equity method investments | 3,327,000 | 1,290,000 | ||||||||||||||||||||||||||||||||||||||
prepaid expenses and other current assets | -11,453,000 | -12,587,000 | 1,649,000 | -18,515,000 | -36,075,000 | 14,310,000 | 270,000 | -6,265,000 | -8,270,000 | -12,000,000 | -6,633,000 | -13,911,000 | -13,758,000 | -17,913,000 | -5,931,000 | |||||||||||||||||||||||||
other non-current assets | -6,495,000 | 15,291,000 | -8,608,000 | 5,338,000 | -2,710,000 | -5,475,000 | -5,014,000 | -81,000 | -10,212,000 | -31,729,000 | -4,805,000 | -1,612,000 | -2,082,000 | -29,066,000 | -496,000 | |||||||||||||||||||||||||
tax payable | 7,149,000 | 14,591,000 | -9,266,000 | -9,086,000 | 6,080,000 | 4,393,000 | 6,886,000 | -4,682,000 | 969,000 | 4,252,000 | 398,000 | -8,738,000 | 733,000 | 6,304,000 | -1,180,000 | 536,000 | 1,766,000 | 126,000 | 135,000 | 33,000 | ||||||||||||||||||||
operating lease liabilities | 1,215,000 | -5,414,000 | -2,094,000 | -3,511,000 | 10,917,000 | 7,129,000 | 1,689,000 | -1,167,000 | 1,550,000 | |||||||||||||||||||||||||||||||
other long-term liabilities | -910,000 | 1,426,000 | -26,778,000 | 1,207,000 | -1,256,000 | 9,982,000 | -1,521,000 | -871,000 | 892,000 | 4,052,000 | 13,107,000 | -1,130,000 | 933,000 | 31,215,000 | -379,000 | 230,000 | 329,000 | 82,000 | ||||||||||||||||||||||
deconsolidation of a subsidiary | 0 | |||||||||||||||||||||||||||||||||||||||
payment for asset acquisition, net of cash acquired | ||||||||||||||||||||||||||||||||||||||||
proceeds from public offering | ||||||||||||||||||||||||||||||||||||||||
proceeds from public offering and hk ipo | ||||||||||||||||||||||||||||||||||||||||
payment to acquire joint venture ("jv") minority interest | ||||||||||||||||||||||||||||||||||||||||
proceeds from loans | ||||||||||||||||||||||||||||||||||||||||
repayment of loans | ||||||||||||||||||||||||||||||||||||||||
operating lease right-of-use assets | 2,258,000 | 1,525,000 | -8,990,000 | -7,181,000 | -699,000 | -2,016,000 | -1,588,000 | |||||||||||||||||||||||||||||||||
proceeds from long-term loans | ||||||||||||||||||||||||||||||||||||||||
repayment of long-term loans | ||||||||||||||||||||||||||||||||||||||||
gain on deconsolidation of entity | ||||||||||||||||||||||||||||||||||||||||
deconsolidation of entity | ||||||||||||||||||||||||||||||||||||||||
proceeds from long-term bank loan | ||||||||||||||||||||||||||||||||||||||||
proceeds from short-term bank loan | 14,899,000 | 11,298,000 | ||||||||||||||||||||||||||||||||||||||
provision for doubtful accounts | 2,022,000 | |||||||||||||||||||||||||||||||||||||||
unrealized gain on equity securities | -6,964,000 | |||||||||||||||||||||||||||||||||||||||
payment for the acquisition of land use right | 0 | |||||||||||||||||||||||||||||||||||||||
cash acquired in business combination, net of cash paid | 0 | |||||||||||||||||||||||||||||||||||||||
proceeds from sale or maturity of available-for-sale securities | 611,443,000 | 257,568,000 | 177,861,000 | 84,028,000 | 96,287,000 | 65,613,000 | ||||||||||||||||||||||||||||||||||
proceeds from public offering, net of underwriter discount | 0 | 758,001,000 | 0 | |||||||||||||||||||||||||||||||||||||
payment of public offering cost | 0 | -414,000 | 0 | |||||||||||||||||||||||||||||||||||||
proceeds from public offering and hk ipo, net of underwriter discount | ||||||||||||||||||||||||||||||||||||||||
payment of public offering and hk ipo costs | ||||||||||||||||||||||||||||||||||||||||
proceeds from long-term bank loans | 0 | |||||||||||||||||||||||||||||||||||||||
repayment of long-term bank loans | ||||||||||||||||||||||||||||||||||||||||
proceeds from short-term loan | 0 | 0 | 0 | 2,470,000 | ||||||||||||||||||||||||||||||||||||
proceeds from shareholder loan | 0 | 0 | ||||||||||||||||||||||||||||||||||||||
realized gain on available-for-sale securities | ||||||||||||||||||||||||||||||||||||||||
non-cash amortization of bond discount | -51,000 | -1,244,000 | -2,408,000 | -3,593,000 | ||||||||||||||||||||||||||||||||||||
unbilled receivable | 0 | 6,114,000 | 2,498,000 | -3,734,000 | 7,824,000 | 11,160,000 | -7,555,000 | |||||||||||||||||||||||||||||||||
prepayment of assets acquisition | ||||||||||||||||||||||||||||||||||||||||
proceeds from follow-on public offering, net of underwriter discount | ||||||||||||||||||||||||||||||||||||||||
payment of follow-on public offering cost | ||||||||||||||||||||||||||||||||||||||||
proceeds from hk ipo and global follow-on public offering | ||||||||||||||||||||||||||||||||||||||||
payment of hk ipo and global follow-on public offering costs | ||||||||||||||||||||||||||||||||||||||||
repayment of long-term bank loan | ||||||||||||||||||||||||||||||||||||||||
restricted cash, current | -296,000 | -333,000 | 14,900,000 | |||||||||||||||||||||||||||||||||||||
restricted cash, non-current | 21,240,000 | 170,000 | 8,991,000 | |||||||||||||||||||||||||||||||||||||
changes in operating assets and liabilities adjusted through accumulated deficit | 0 | 0 | 2,291,000 | |||||||||||||||||||||||||||||||||||||
disposal gain on available-for-sale securities | -996,000 | -810,000 | ||||||||||||||||||||||||||||||||||||||
changes in fair value of financial instruments | 0 | 0 | 1,514,000 | |||||||||||||||||||||||||||||||||||||
loss on disposal of property and equipment | 125,000 | 0 | 7,000 | |||||||||||||||||||||||||||||||||||||
disposal loss on available-for-sale securities | 137,000 | 228,000 | 712,000 | |||||||||||||||||||||||||||||||||||||
proceeds from disposal of property and equipment | ||||||||||||||||||||||||||||||||||||||||
proceeds from exercise of warrants and rental deferral option | ||||||||||||||||||||||||||||||||||||||||
proceeds from option exercises | 8,803,000 | 10,277,000 | 4,268,000 | 6,314,000 | 3,048,000 | |||||||||||||||||||||||||||||||||||
discount provided on sale of ordinary shares for business combination | 0 | |||||||||||||||||||||||||||||||||||||||
other non-cash income | -1,854,000 | -482,000 | ||||||||||||||||||||||||||||||||||||||
net cash from (provided by) investing activities | ||||||||||||||||||||||||||||||||||||||||
restricted cash | 14,131,000 | 17,460,000 | ||||||||||||||||||||||||||||||||||||||
non-cash activities: | ||||||||||||||||||||||||||||||||||||||||
cash, cash equivalents, and restricted cash at beginning of year | 239,602,000 | |||||||||||||||||||||||||||||||||||||||
cash, cash equivalents, and restricted cash at end of year | 508,094,000 | |||||||||||||||||||||||||||||||||||||||
other non-cash expenses | -34,000 | |||||||||||||||||||||||||||||||||||||||
deferred rental | ||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of convertible preferred shares | ||||||||||||||||||||||||||||||||||||||||
payment of convertible preferred shares issuance cost | ||||||||||||||||||||||||||||||||||||||||
net increase in cash and cash equivalents | 31,092,000 | -52,496,000 | 163,256,000 | 10,236,000 | 27,448,000 | -150,422,000 | 190,637,000 | |||||||||||||||||||||||||||||||||
cash and cash equivalents at beginning of period | 0 | 0 | 0 | 87,514,000 | 0 | 0 | 17,869,000 | |||||||||||||||||||||||||||||||||
cash and cash equivalents at end of period | 31,092,000 | -52,496,000 | 163,256,000 | 97,750,000 | 27,448,000 | -150,422,000 | 208,506,000 | |||||||||||||||||||||||||||||||||
conversion of senior promissory note | 0 | 0 | 14,693,000 | |||||||||||||||||||||||||||||||||||||
conversion of deferred rental | 0 | 0 | 980,000 | |||||||||||||||||||||||||||||||||||||
conversion of convertible preferred shares | 0 | 0 | 176,084,000 | |||||||||||||||||||||||||||||||||||||
exercise of warrants and option | ||||||||||||||||||||||||||||||||||||||||
follow-on public offering costs accrued in accounts payable | ||||||||||||||||||||||||||||||||||||||||
operating activities | ||||||||||||||||||||||||||||||||||||||||
advances from customers | ||||||||||||||||||||||||||||||||||||||||
investing activities | ||||||||||||||||||||||||||||||||||||||||
purchase of available-for-sale securities | -436,419,000 | |||||||||||||||||||||||||||||||||||||||
investment in time deposits | ||||||||||||||||||||||||||||||||||||||||
financing activities | ||||||||||||||||||||||||||||||||||||||||
proceeds from exercise of warrants and options | 63,000 | |||||||||||||||||||||||||||||||||||||||
exercise of warrants and options | ||||||||||||||||||||||||||||||||||||||||
initial public offering costs accrued in accrued expenses and other payables | 0 | |||||||||||||||||||||||||||||||||||||||
depreciation expense | 540,000 | 864,000 | ||||||||||||||||||||||||||||||||||||||
payment for the acquisition of land use rights | ||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of ordinary shares, net of underwriter discount | ||||||||||||||||||||||||||||||||||||||||
payment of initial public offering cost | ||||||||||||||||||||||||||||||||||||||||
proceeds from employee option exercises | ||||||||||||||||||||||||||||||||||||||||
loss on sale of available-for-sale securities | ||||||||||||||||||||||||||||||||||||||||
interest expense | 25,000 | 0 | 93,000 | |||||||||||||||||||||||||||||||||||||
payment for land auction deposit | ||||||||||||||||||||||||||||||||||||||||
net cash provided by investing activities | 43,543,000 | 40,343,000 | ||||||||||||||||||||||||||||||||||||||
net cash provided by financing activities | 2,533,000 | 7,640,000 | 4,521,000 | 170,049,000 | ||||||||||||||||||||||||||||||||||||
depreciation expenses | 505,000 | 492,000 | 439,000 | |||||||||||||||||||||||||||||||||||||
proceeds from disposal of available-for-sale securities | 67,761,000 | 46,900,000 | 43,646,000 | |||||||||||||||||||||||||||||||||||||
proceeds from issuance of ordinary shares, net of initial public offering costs | 0 | 0 | 167,931,000 | |||||||||||||||||||||||||||||||||||||
proceeds from issuance of preferred shares | ||||||||||||||||||||||||||||||||||||||||
conversion of warrant and option liabilities | 0 | 0 | 3,687,000 | |||||||||||||||||||||||||||||||||||||
proceeds from exercise of warrants | 0 | 2,118,000 | ||||||||||||||||||||||||||||||||||||||
initial public offering costs accrued for in accrued expenses and other payables | 166,000 | |||||||||||||||||||||||||||||||||||||||
gain on debt extinguishment | ||||||||||||||||||||||||||||||||||||||||
acquisition of non-controlling interest | ||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of convertible promissory notes | ||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of secured guaranteed convertible promissory note | ||||||||||||||||||||||||||||||||||||||||
proceeds from exercise of share options | ||||||||||||||||||||||||||||||||||||||||
proceeds due to related parties | ||||||||||||||||||||||||||||||||||||||||
repayment to related party | ||||||||||||||||||||||||||||||||||||||||
net cash (used in) provided by financing activities | ||||||||||||||||||||||||||||||||||||||||
repayment of subordinated convertible promissory note, convertible promissory notes and secured guaranteed convertible promissory note | ||||||||||||||||||||||||||||||||||||||||
repayment of due to related parties |
