7Baggers

BioCryst Pharmaceuticals Quarterly Balance Sheets Chart

Quarterly
 | 
Annual
 
 Cash and Cash Eq  
 Account Payables  
 Deferred Revenue  
 Inventory  
20200930 20201231 20210331 20210630 20210930 20211231 20220331 20220630 20220930 20221231 20230331 20230630 20230930 20231231 20240331 20240630 20240930 20241231 20250331 20250630 072.06144.11216.17288.22360.28432.33504.39Milllion

BioCryst Pharmaceuticals Quarterly Balance Sheets Table

Quarterly
 | 
Annual
 
Unit: USD2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 2009-12-31 2009-09-30 2009-06-30 2009-03-31 2008-12-31 2008-09-30 2008-06-30 2008-03-31 2007-12-31 2007-09-30 2007-06-30 2007-03-31 2006-12-31 2006-09-30 2006-06-30 2006-03-31 2005-12-31 2005-09-30 2005-06-30 2005-03-31 2004-12-31 2004-09-30 2004-06-30 
                                                                                       
  assets                                                                                     
  current assets:                                                                                     
  cash and cash equivalents88,033,000 105,190,000 104,713,000 96,841,000 78,410,000 84,333,000 110,643,000 150,905,000 146,215,000 155,136,000 304,767,000 246,899,000 272,571,000 395,504,000 504,389,000 199,597,000 210,314,000 226,902,000 272,127,000 96,492,000 173,468,000 101,873,000 114,172,000 29,903,000 30,760,000 34,804,000 26,731,000 52,584,000 27,104,000 43,767,000 50,282,000 117,776,000 39,696,000 75,158,000 22,104,000 35,387,000 8,661,000 12,902,000 28,899,000 46,627,000 76,781,000 48,367,000 54,540,000 121,157,000 121,519,000 13,584,000 21,164,000 26,050,000 19,767,000 14,805,000 20,891,000 23,959,000 21,924,000 27,661,000 16,444,000 22,441,000 17,008,000 31,342,000 13,622,370 11,174,000 14,021,000 19,876,000 41,124,937 18,226,000 13,810,000 16,305,000 22,342,058 15,952,000 25,141,000 27,875,000 31,155,320 44,092,000 7,178,000 9,207,000 4,417,528 7,733,000 25,055,000 43,015,000 29,156,827 9,097,000 9,240,000 22,049,000 8,838,464 13,809,000 17,046,000 
  restricted cash492,000 291,000 210,000 813,000 1,795,000 1,798,000 1,804,000 1,584,000 1,574,000 1,463,000 1,472,000 1,444,000 1,448,000 3,354,000 3,345,000 4,296,000 4,348,000 4,008,000 2,221,000 2,213,000 2,188,000 1,559,000 1,551,000 1,547,000 4,629,000 2,394,000 1,544,000 1,506,000 7,625,000 4,599,000 3,286,000 3,122,000 5,357,000 2,798,000 1,546,000 1,506,000 4,426,000 1,965,000 1,612,000 1,622,000 1,569,000 2,637,000 150,000 150,000 150,000 150,000 151,000 150,000 2,129,000 616,000 308,000 300,000 2,230,000 955,000 625,000 625,000 1,416,000 625,000 625,000 625,000 625,000 625,000 625,000                       
  short-term investments172,005,000 189,902,000 216,137,000                                                                                   
  trade receivables91,177,000 93,394,000 79,069,000 72,456,000 68,759,000 60,586,000 56,950,000 53,646,000 57,667,000 48,639,000 50,599,000 42,610,000 41,491,000 36,415,000 29,413,000 26,212,000 27,620,000 18,386,000                                                                    
  inventory5,044,000 6,873,000 8,087,000 7,562,000 4,450,000 29,781,000 28,683,000 29,630,000 27,033,000 27,466,000 27,533,000 27,019,000 23,378,000 16,144,000 15,791,000    7,039,000     1,776,000 1,000,000 600,000 1,649,000 821,000 221,000 7,000   1,305,000 655,000 500,000 2,232,000 1,949,000 1,949,000 1,612,000  1,308,000 1,210,000 683,000            263,000                               
  prepaid expenses and other current assets12,541,000 14,327,000 13,752,000 16,281,000 16,426,000 18,381,000 19,542,000 20,016,000 14,112,000 15,157,000 12,586,000 11,070,000 11,053,000 12,333,000 9,986,000 8,975,000 5,560,000 5,908,000 5,528,000 5,241,000 3,016,000 5,249,000 4,422,000 3,447,000 2,341,000 2,087,000 2,390,000 2,445,000 1,729,000 2,397,000 1,381,000 1,421,000 1,524,000 1,721,000 1,438,000 2,007,000 1,674,000 3,221,000 4,870,000 4,970,000 5,449,000 4,322,000 6,172,000 4,546,000 5,020,000 835,000 1,725,000 1,656,000 1,179,000 1,781,000 1,097,000 826,000 344,000 407,000 378,000 795,000 260,000 676,000 1,004,430 1,187,000 1,421,000 1,275,000 1,055,712 3,201,000 6,744,000 692,000 1,136,842 2,331,000 2,369,000 3,131,000 1,879,463 2,101,000 2,287,000 1,865,000 3,775,975 1,705,000 4,504,000 2,727,000 839,662 644,000 739,000 671,000 699,284 571,000 541,000 
  current assets held for sale29,170,000                                                                                     
  total current assets398,462,000 409,977,000 421,968,000 427,125,000 363,457,000 447,100,000 495,966,000 502,466,000 511,056,000 490,883,000 516,500,000 509,001,000 494,853,000 511,714,000 566,136,000 252,743,000 265,802,000 273,771,000 323,800,000 162,436,000 203,837,000 125,508,000 164,345,000 78,803,000 103,719,000 117,649,000 114,352,000 128,495,000 92,669,000 104,156,000 125,391,000 175,370,000 92,263,000 113,502,000 66,987,000 64,632,000 46,112,000 50,425,000 65,990,000 84,502,000 107,088,000 81,366,000 89,343,000 135,144,000 138,250,000 35,731,000 42,121,000 46,839,000 33,530,000 35,407,000 41,978,000 46,582,000 45,064,000 52,949,000 52,858,000 60,446,000 79,877,000 100,451,000 87,418,974 89,762,000 79,755,000 92,790,000 111,022,152 50,686,000 57,451,000 65,129,000 75,024,706 80,111,000 55,620,000 77,259,000 91,704,652 91,561,000 51,428,000 47,288,000 45,789,686 48,659,000 61,246,000 71,794,000 81,100,061 31,479,000 33,791,000 41,708,000 23,872,379 23,524,000 24,705,000 
  long-term inventory22,205,000 25,097,000 23,187,000 21,633,000 24,525,000                                                                                 
  property and equipment8,457,000 7,593,000 7,777,000 7,421,000 7,663,000 7,831,000 7,910,000 8,999,000 8,438,000 8,376,000 8,617,000 8,464,000 8,702,000 8,799,000 8,714,000 7,829,000 7,669,000 7,035,000 7,113,000 7,142,000 7,149,000 7,270,000 7,347,000 7,452,000 7,551,000 7,644,000 9,135,000 9,236,000 9,390,000 9,395,000 9,546,000 9,613,000 9,602,000 9,753,000 9,922,000 10,095,000 10,112,000 8,362,000 5,149,000                                               
  long-term investments10,101,000 20,548,000 20,323,000 19,426,000 64,317,000    3,445,000 3,432,000 18,077,000 34,332,000   6,829,000                                                                       
  right of use assets11,546,000 11,982,000 12,008,000                                                                                   
  other assets3,592,000 4,850,000 5,157,000 15,649,000 12,457,000 12,961,000 13,084,000 11,459,000 6,946,000 7,046,000 6,806,000 6,797,000 6,983,000 7,207,000 6,472,000 5,191,000 3,813,000 3,625,000 3,802,000 3,646,000 3,720,000 3,811,000 3,590,000 4,245,000 4,333,000 5,390,000 978,000 1,420,000 841,000 222,000 2,027,000 1,955,000 1,871,000 2,271,000 3,813,000 2,190,000 1,610,000 2,714,000 5,468,000 5,239,000 5,699,000 6,495,000 6,031,000 1,277,000 2,700,000 4,495,000 3,620,000 5,075,000 5,695,000 6,074,000 8,694,000 9,114,000 8,704,000 7,734,000 7,433,000 7,157,000 6,695,000 5,930,000                            
  non-current assets held for sale2,825,000                                                                                     
  total assets457,188,000 480,047,000 490,420,000 491,254,000 472,419,000 467,892,000 516,960,000 522,924,000 529,885,000 509,737,000 550,000,000 558,594,000 510,538,000 527,720,000 588,151,000 265,763,000 277,284,000 284,431,000 334,715,000 176,226,000 214,706,000 136,589,000 175,282,000 90,500,000 116,344,000 142,338,000 146,841,000 168,308,000 136,644,000 155,372,000 178,259,000 191,492,000 113,509,000 129,513,000 89,847,000 91,502,000 82,217,000 102,881,000 124,555,000 138,956,000 150,181,000 129,867,000 136,874,000 137,125,000 141,975,000 43,387,000 48,866,000 53,205,000 39,916,000 46,899,000 57,439,000 64,094,000 76,236,000 80,085,000 82,208,000 92,511,000 108,412,000 122,766,000 109,447,235 111,354,000 116,103,000 124,655,000 142,190,106 60,588,000 64,694,000 72,602,000 84,691,677 99,351,000 107,649,000 129,144,000 142,716,839 141,154,000 78,426,000 67,916,000 68,485,421 80,198,000 91,879,000 102,224,000 99,248,394 38,153,000 43,425,000 49,489,000 32,468,571 37,885,000 41,765,000 
  liabilities and stockholders’ deficit                                                                                     
  current liabilities:                                                                                     
  accounts payable8,589,000 10,049,000 11,644,000 13,482,000 7,786,000 11,910,000 20,893,000 10,567,000 13,889,000 6,254,000 14,356,000 8,622,000 12,024,000 13,881,000 27,808,000 19,693,000 10,087,000 13,529,000 18,713,000 11,616,000 9,354,000 10,061,000 13,988,000 10,084,000 8,298,000 6,935,000 7,769,000 7,911,000 4,122,000 3,588,000 6,337,000 4,603,000 1,844,000 5,433,000 4,269,000 2,760,000 5,051,000 7,691,000 9,307,000 3,782,000 3,822,000 5,307,000 2,849,000 2,266,000 2,360,000 1,352,000 4,174,000 1,241,000 989,000 1,073,000 3,974,000 2,293,000 3,328,000 2,062,000 2,497,000 3,583,000 5,012,000 6,254,000 8,200,822 3,261,000 1,438,000 6,352,000 18,069,767 3,200,000 2,793,000 4,185,000 5,265,947 3,239,000 9,317,000 14,763,000 19,771,375 16,383,000 10,578,000 8,209,000 5,886,967 7,974,000 5,206,000 6,867,000 8,812,985 2,231,000 1,208,000 1,672,000 1,970,443 2,024,000 849,000 
  accrued expenses107,114,000 92,635,000 113,292,000 104,197,000 89,598,000 79,249,000 102,882,000 77,392,000 75,300,000 75,212,000 87,565,000 69,265,000 79,711,000 63,584,000 72,670,000 56,308,000 48,765,000 32,719,000 33,942,000 30,462,000 24,843,000 20,192,000 21,365,000 24,954,000 19,343,000 16,547,000 15,891,000 15,120,000 19,409,000 15,624,000 12,699,000 11,871,000 12,329,000 11,335,000 10,836,000 10,782,000 11,783,000 17,328,000 16,237,000 23,027,000 19,001,000 12,291,000 11,723,000 11,252,000 7,309,000 6,312,000 5,742,000 7,668,000 5,773,000 5,647,000 9,860,000 8,035,000 8,206,000 9,253,000 12,616,000 12,030,000 12,309,000 11,997,000 16,486,920 13,613,000 10,250,000 11,336,000 15,794,800 11,145,000 7,248,000 6,010,000 8,442,398 9,107,000 2,730,000 5,498,000 2,863,815 2,902,000 1,249,000 1,537,000 1,506,712 1,630,000 1,547,000 1,482,000 1,252,018 1,216,000 1,053,000 1,011,000 563,961 1,244,000 1,209,000 
  operating lease liabilities392,000 1,071,000 937,000 1,049,000 1,026,000 1,098,000 1,058,000                                                                               
  finance lease liabilities1,616,000 1,795,000 1,835,000 1,839,000 1,681,000 1,642,000 1,590,000                                                                               
  royalty financing obligations35,741,000 34,305,000 32,676,000 33,000,000 28,974,000 26,022,000 23,565,000 535,186,000 526,121,000 514,411,000 501,655,000 489,781,000 477,666,000 464,225,000 449,375,000                                                                       
  current liabilities held for sale23,708,000                                                                                     
  total current liabilities177,160,000 139,855,000 160,384,000 153,567,000 129,065,000 119,921,000 149,988,000 90,763,000 93,498,000 85,157,000 105,514,000 81,637,000 95,390,000 81,017,000 103,718,000 133,608,000 115,601,000 101,201,000 105,654,000 111,777,000 102,650,000 92,699,000 92,335,000 82,169,000 71,948,000 66,326,000 69,477,000 64,357,000 74,173,000 75,342,000 74,836,000 69,237,000 58,937,000 58,557,000 54,360,000 51,520,000 56,194,000 63,070,000 64,453,000 64,444,000 63,772,000 61,862,000 57,687,000 49,823,000 44,937,000 13,689,000 15,256,000 13,182,000 11,958,000 11,324,000 17,224,000 12,564,000 19,106,000 16,165,000 26,299,000 19,333,000 21,960,000 21,771,000 27,822,024 20,246,000 15,098,000 21,094,000 37,253,000 17,735,000 13,464,000 13,562,000 17,108,005 17,559,000 17,346,000 25,945,000 28,117,599 24,735,000 17,157,000 13,579,000 10,734,616 12,905,000 9,681,000 11,007,000 11,381,766 3,447,000 2,261,000 2,683,000 2,834,359 3,268,000 2,058,000 
  secured term loan242,794,000 315,413,000 314,869,000 314,333,000 313,822,000 308,484,000 303,231,000   232,522,000 231,624,000 223,867,000 144,516,000 140,236,000 136,082,000 132,050,000 126,796,000 123,039,000 119,735,000                                                                   
  non-current liabilities held for sale454,000                                                                                     
  total liabilities878,782,000 931,974,000 966,354,000 959,817,000                                                                            3,747,000 2,561,000 2,983,000    
  stockholders’ deficit:                                                                                     
  preferred stock, 0.01 par value; shares authorized - 5,000; no shares issued and outstanding at june 30, 2025 and december 31, 2024                                                                                     
  common stock2,099,000 2,092,000 2,085,000 2,071,000 2,066,000 2,063,000 2,058,000 1,898,000 1,895,000 1,889,000 1,879,000 1,864,000 1,859,000 1,856,000 1,843,000 1,798,000 1,787,000 1,777,000 1,769,000 1,766,000 1,764,000 1,542,000 1,541,000 1,104,000 1,104,000 1,103,000 1,101,000 1,096,000 989,000 987,000 984,000 984,000 804,000 804,000 738,000 738,000 737,000 737,000 734,000 733,000 732,000 725,000 720,000 719,000 717,000 601,000 591,000 591,000 542,000 514,000 509,000 509,000 501,000 492,000 457,000 452,000 451,000 451,000 449,590 449,000 449,000 440,000 439,068  383,000 383,000 382,751 382,000 381,000 381,000 379,672 380,000 295,000 294,000 292,488 292,000 292,000 291,000 288,135 264,000 262,000 262,000 217,583   
  additional paid-in capital1,339,584,000 1,314,857,000 1,291,100,000 1,270,318,000 1,250,983,000 1,237,537,000 1,222,236,000 1,205,744,000 1,191,981,000 1,177,192,000 1,158,118,000 1,138,654,000 1,125,453,000 1,115,443,000 1,098,498,000 1,040,769,000 1,022,975,000 1,010,779,000 1,002,408,000 994,811,000 991,574,000 880,319,000 877,300,000 795,589,000 790,076,000 784,278,000 780,400,000 776,724,000 720,587,000 718,037,000 714,869,000 711,965,000 620,453,000 618,009,000 566,913,000 564,791,000 562,634,000 560,762,000 558,113,000 556,095,000 553,610,000 546,698,000 542,943,000 538,959,000 536,864,000 426,520,000 420,988,000 420,097,000 399,684,000 393,738,000 391,611,000 390,783,000 386,966,000 382,181,000 367,829,000 365,868,000 364,593,000 363,235,000 361,520,258 360,153,000 358,604,000 350,325,000 348,571,914 300,989,000 298,106,000 296,626,000 295,207,583 293,831,000 292,132,000 290,750,000 288,683,369 287,330,000 220,321,000 217,979,000 216,310,578 215,107,000 213,920,000 212,674,000 210,014,946 178,844,000 177,659,000 177,653,000 154,880,528 154,575,000 154,369,000 
  accumulated other comprehensive income1,646,000 1,132,000 921,000 2,293,000 557,000 771,000 1,337,000 800,000 690,000 585,000 26,000 -98,000 15,000 186,000 177,000 114,000 87,000 182,000 3,000 9,000 3,000 14,000 39,000 60,000 41,000           22,000 46,000 48,000    10,000 -130,000 2,000 3,000 2,000 4,000 2,000 6,000 15,000 27,000 40,000 40,000 49,000 40,000 50,000 92,000 82,000 105,710 119,000 63,000 77,000 -25,783 40,000 40,000 68,000 103,507 133,000 252,000 726,000 378,057 152,000 -4,000 26,000 32,463 54,000 9,000         
  accumulated deficit-1,764,923,000 -1,770,008,000 -1,770,040,000 -1,743,245,000 -1,729,212,000 -1,716,538,000 -1,681,159,000 -1,619,428,000 -1,583,279,000 -1,507,953,000 -1,454,620,000 -1,383,079,000 -1,340,559,000 -1,281,700,000 -1,207,504,000 -1,189,725,000 -1,130,924,000 -1,087,726,000 -1,023,442,000 -962,949,000 -916,834,000 -878,227,000 -840,628,000 -838,006,000 -800,414,000 -762,785,000 -731,969,000 -704,537,000 -674,940,000 -656,494,000 -631,843,000 -612,300,000 -597,166,000 -580,280,000 -566,061,000 -561,558,000 -550,030,000 -533,749,000 -510,917,000 -492,782,000 -478,161,000 -483,062,000 -467,898,000 -456,226,000 -447,495,000 -432,846,000 -422,709,000 -417,280,000 -409,279,000 -397,107,000 -392,601,000 -381,548,000 -371,848,000 -359,572,000 -353,520,000 -340,328,000 -325,870,000 -309,599,000 -296,572,332 -286,372,000 -275,508,000 -265,315,000 -262,719,149 -277,871,000 -267,244,000 -258,560,000 -249,267,614 -259,338,000 -250,343,000 -237,634,000 -224,536,044 -222,253,000 -211,269,000 -204,306,000 -195,480,520 -185,431,000 -169,828,000 -159,745,000 -151,862,667 -144,702,000 -137,057,000 -131,409,000 -125,763,899 -120,475,000 -115,179,000 
  total stockholders’ deficit-421,594,000 -451,927,000 -475,934,000 -468,563,000 -475,606,000 -476,167,000 -455,528,000 -410,986,000 -388,713,000 -328,287,000 -294,597,000 -242,659,000 -213,232,000 -164,215,000 -106,986,000                               -5,723,000   -9,047,000 -2,840,000                                    
  total liabilities and stockholders’ deficit457,188,000 480,047,000 490,420,000 491,254,000 472,419,000 467,892,000 516,960,000 522,924,000 529,885,000 509,737,000 550,000,000 558,594,000 510,538,000 527,720,000 588,151,000                                                                       
  preferred stock, 0.01 par value; shares authorized - 5,000; no shares issued and outstanding at march 31, 2025 and december 31, 2024                                                                                     
  preferred stock, 0.01 par value; shares authorized - 5,000; no shares issued and outstanding at december 31, 2024 and 2023                                                                                     
  investments   233,172,000 193,617,000 252,221,000 278,344,000 246,685,000 264,455,000 243,022,000 119,543,000 179,959,000 144,912,000 47,964,000 3,212,000  8,114,000 13,454,000 28,239,000 46,827,000 15,935,000 11,185,000 22,054,000 38,532,000 61,387,000 72,753,000 77,736,000 67,737,000 53,636,000 47,540,000 64,115,000 43,848,000 40,977,000 23,524,000 32,546,000 17,434,000 27,079,000 22,914,000 22,664,000 23,700,000 17,584,000 19,160,000 18,232,000 5,977,000 10,589,000 17,807,000 16,891,000 16,541,000 9,358,000 13,462,000 14,708,000 17,062,000 12,958,000 15,617,000 25,274,000                               
  preferred stock, 0.01 par value; shares authorized - 5,000; no shares issued and outstanding at september 30, 2024 and december 31, 2023                                                                                     
  preferred stock, 0.01 par value; shares authorized - 5,000; no shares issued and outstanding at june 30, 2024 and december 31, 2023                                                                                     
  preferred stock, 0.01 par value; shares authorized - 5,000; no shares issued and outstanding at march 31, 2024 and december 31, 2023                                                                                     
  deferred revenue       522,000 1,779,000 1,200,000 1,224,000 1,554,000 1,521,000 1,471,000 1,421,000 602,000 551,000                                               2,509,000 2,528,000 2,547,000 2,565,285 4,345,000 4,345,000 4,756,000 4,658,266 4,680,000 4,620,000 3,161,000 2,699,463 2,699,000 2,391,000 2,162,000 873,786 300,000 300,000 300,000 300,000 300,000 300,000 
  preferred stock, 0.01 par value; shares authorized — 5,000; no shares outstanding at december 31, 2023 and 2022                                                                                     
  lease financing obligation       2,282,000 2,530,000 2,491,000 2,369,000 2,196,000 2,134,000 2,081,000 1,819,000 1,452,000 981,000 1,001,000 1,179,000 925,000 1,096,000 1,301,000 1,377,000    47,000 66,000 78,000 76,000 75,000 73,000 2,704,000 2,704,000 2,704,000 2,675,000 2,589,000 2,506,000 2,375,000                                               
  secured term loans       297,995,000 293,176,000                                                                             
  preferred stock, 0.01 par value; shares authorized - 5,000; no shares issued and outstanding                                                                                     
  stockholders’ equity:                                                                                     
  preferred stock, 0.01 par value; shares authorized — 5,000; no shares outstanding                                                                                     
  interest payable               25,553,000 25,217,000 23,547,000 21,670,000 19,304,000 17,806,000 16,381,000 14,904,000 13,423,000 14,745,000 13,392,000 11,848,000 10,427,000 14,832,000 13,465,000 12,095,000 10,705,000 11,587,000 10,291,000 8,990,000 7,563,000 9,203,000 7,974,000 6,746,000 5,517,000 4,450,000 7,241,000 6,029,000 4,824,000 3,786,000 4,552,000 3,867,000 2,734,000 3,658,000 3,068,000 1,998,000 928,000 3,500,000 2,450,000 1,400,000 350,000 1,318,000 257,000                            
  non-recourse notes payable               30,000,000 30,000,000 30,000,000 30,000,000 29,890,000 29,780,000 29,671,000 29,561,000 29,451,000 29,341,000 29,231,000 29,121,000 29,012,000 28,902,000 28,792,000 28,682,000 28,572,000 28,463,000 28,353,000 28,243,000 28,133,000 28,023,000 27,914,000 30,000,000 30,000,000 30,000,000 30,000,000 30,000,000 30,000,000 30,000,000 30,000,000 30,000,000 30,000,000 30,000,000 30,000,000 30,000,000 30,000,000 30,000,000 30,000,000 30,000,000 30,000,000 30,000,000 30,000,000                            
  inventories               13,663,000 9,846,000 5,113,000  6,241,000 5,233,000                               263,000 263,000 263,000  898,000 898,000 898,000 898,076 898,000 907,000 844,000 6,281,263                       
  liabilities and stockholders’ equity                                                                                     
  royalty financing obligation               142,114,000 136,862,000 131,296,000 124,717,000                                                                   
  preferred stock, 0.001 par value; shares authorized - 5,000; no shares issued and outstanding                                                                                     
  total stockholders’ equity               -147,044,000 -106,075,000 -74,988,000  33,637,000 76,507,000 3,648,000 38,252,000  -9,193,000 22,507,000 49,235,000 72,873,000 46,184,000 62,054,000 83,767,000 100,632,000 24,076,000 38,530,000 1,578,000 3,993,000 13,387,000 27,798,000 47,724,000 64,045,000 76,089,000 64,371,000 75,635,000 83,454,000 90,089,000   3,410,000    9,784,000 15,659,000 23,150,000 14,806,000 26,042,000 39,266,000 54,169,000 65,503,226 74,349,000 83,608,000 85,527,000 86,266,050 23,545,000 31,285,000 38,517,000 46,426,227 35,008,000 42,423,000 54,223,000 64,905,054 65,609,000 9,343,000 13,993,000 21,155,009  44,393,000 53,220,000 58,440,414 34,406,000 40,864,000 46,506,000 29,334,212 34,317,000 39,407,000 
  total liabilities and stockholders’ equity               265,763,000 277,284,000 284,431,000 334,715,000 176,226,000 214,706,000 136,589,000 175,282,000 90,500,000 116,344,000 142,338,000 146,841,000 168,308,000 136,644,000 155,372,000 178,259,000 191,492,000 113,509,000 129,513,000 89,847,000 91,502,000 82,217,000 102,881,000 124,555,000 138,956,000 150,181,000 129,867,000 136,874,000 137,125,000 141,975,000 43,387,000 48,866,000 53,205,000 39,916,000 46,899,000 57,439,000 64,094,000 76,236,000 80,085,000 82,208,000 92,511,000 108,412,000 122,766,000 109,447,235 111,354,000 116,103,000 124,655,000 142,190,106 60,588,000 64,694,000 72,602,000 84,691,677 99,351,000 107,649,000 129,144,000 142,716,839 141,154,000 78,426,000 67,916,000 68,485,421  91,879,000 102,224,000 99,248,394 38,153,000 43,425,000 49,489,000 32,468,571 37,885,000 41,765,000 
  deferred collaboration revenue                 405,000 150,000 432,000 715,000 1,067,000 2,120,000 221,000 221,000 221,000 221,000 200,000 300,000 7,300,000 8,484,000 8,686,000 1,717,000 1,869,000 2,022,000 2,282,000 2,134,000 2,163,000 2,163,000 2,102,000 6,453,000 1,490,000 1,481,000 1,481,000 1,482,000 1,473,000 1,473,000 1,539,000 1,538,000 1,536,000 1,392,000 1,308,000 4,072,000 2,400,000 9,786,000 3,370,000 3,321,000 2,497,000 2,496,534 2,497,000 2,497,000 2,497,000 2,496,534                       
  receivables                  8,646,000                         3,238,000 897,000 3,280,000 2,115,000 2,369,000 1,024,000 4,325,000 4,562,000                                   
  senior credit facility                   19,148,000 19,056,000 14,026,000 9,020,000 4,036,000   4,580,000 1,621,000 6,530,000 6,497,000 6,464,000 4,727,000 2,997,000 1,276,000 22,777,000 22,665,000                                                  
  total stockholders’ (deficit) equity                  -19,262,000     -41,253,000                       -1,126,000    -454,000                                   
  receivables from collaborations                   5,422,000 3,997,000 5,642,000 22,146,000 3,598,000 3,602,000 5,002,000 4,293,000 3,394,000 2,342,000 5,694,000 6,117,000 8,985,000 3,325,000 9,564,000 8,768,000 5,968,000 2,234,000 7,384,000 6,243,000 7,495,000 4,296,000 5,594,000 3,849,000         3,768,000 5,084,000 5,852,000 5,831,000 11,634,000 15,961,000 26,062,000 30,227,210 25,564,000 20,531,000 26,627,000 33,722,207 11,626,000 8,075,000 9,847,000 11,982,430 13,102,000 14,850,000 28,579,000 39,127,676    4,556,145           
  deferred rent                          54,000 81,000 107,000 131,000 155,000 178,000 201,000 223,000 244,000 265,000 297,000 313,000 329,000 345,000 361,000 378,000              138,000 151,000 52,000 52,537 52,000 52,000 52,000 52,537 53,000 53,000 40,000 40,000 40,000 40,000 40,000                
  preferred stock, 0.001 par value; shares authorized — 5,000; no shares outstanding                                                                                     
  other non-current liabilities                       3,543,000 3,742,000 3,889,000                                                            
  preferred stock, 0.001 par value; shares authorized — 5,000; no shares issued and outstanding                                                                                     
  deferred collaboration expense                         9,000 9,000 8,000 12,000 152,000 210,000 218,000 79,000 82,000 85,000 98,000 89,000 90,000 90,000 88,000 101,000 76,000 76,000 76,000 75,000 75,000 75,000 73,000 73,000 418,000 412,000 404,000 519,000 452,000 2,301,000 753,000 751,000 719,000 718,719 719,000 719,000 374,000 374,221 374,000 376,000 376,000 376,972 10,719,000 10,951,000 11,182,000 11,407,120 11,640,000 11,872,000 11,470,000 10,597,750 10,787,000 7,824,000 7,900,000 5,825,243       
  accumulated other comprehensive loss                         -89,000 -297,000 -410,000 -452,000 -476,000 -243,000 -17,000 -15,000 -3,000 -12,000    -206,000 -1,000 -92,000                                             
  foreign currency derivative                                   1,904,000 974,000        2,805,000 981,000  1,581,000 1,678,000 2,791,000 4,749,000 5,531,000 4,959,000 3,962,000 4,000,000 2,926,000 2,340,000 1,342,000                            
  receivables from product sales                                          5,641,000                                           
  deferred product sales revenue                                       16,000 46,000 5,533,000 5,605,000                                           
  furniture and equipment                                       1,146,000 1,047,000 727,000 207,000 210,000 216,000 260,000 306,000 359,000 425,000 486,000 583,000 751,000 882,000 999,000 1,098,000 1,353,000 1,537,000 1,734,000 1,929,049 3,087,000 3,330,000 3,564,000 3,871,653 4,175,000 4,429,000 4,566,000 4,880,475 5,271,000 5,232,000 5,086,000 5,294,079 4,120,000 3,169,000 3,062,000 3,029,271 2,679,000 2,671,000 2,760,000 2,407,954 2,342,000 2,456,000 2,634,000 2,817,154 2,948,000 3,163,000 
  preferred stock, 0.001 par value; shares authorized— 5,000; no shares issued and outstanding                                                                                     
  interest reserve                                                    1,742,000 1,742,000 1,742,000 1,742,000 3,000,000 3,000,000                            
  commitments and contingencies                                                                                     
  marketable securities                                                       21,558,000 40,583,000 37,129,000 40,323,169 49,595,000 41,531,000 43,169,000 27,838,812 17,259,000 28,446,000 37,909,000 39,186,404 48,726,000 13,260,000 17,674,000 19,542,193 24,620,000 23,690,000 27,849,000 33,040,038 36,082,000 29,712,000         
  preferred stock: 5,000 shares authorized; none issued and outstanding                                                                                     
  accrued vacation                                                         714,000 585,211 823,000 861,000 857,000 839,362 828,000 842,000 780,000 794,375 828,000 914,000 888,000 824,143 770,000 710,000 672,000 641,474 602,000 537,000 496,000 442,977    299,955   
  preferred stock: shares authorized — 5,000 series b junior participating preferred stock, .001 par value; shares authorized — 95; shares issued and outstanding — none                                                                                     
  preferred stock: shares authorized — 5,000,000 series b junior participating preferred stock, .001 par value; shares authorized — 95,000; shares issued and outstanding — none                                                                                     
  preferred stock: shares authorized – 5,000                                                                                     
  series b junior participating preferred stock, .001 par value; shares authorized – 45; shares issued and outstanding – none                                                                                     
  95,000; shares issued and outstanding – 38,735 in 2009 and 38,275 in 2008                                                               387,000                      
  preferred stock: shares authorized — 5,000                                                                                     
  series b junior participating preferred stock, .001 par value; shares authorized — 45; shares issued and outstanding — none                                                                                     
  preferred stock: shares authorized – 5,000 series b junior participating preferred stock, .001 par value; shares authorized – 45; shares issued and outstanding – none                                                                                     
  preferred stock: shares authorized — 5,000,000 series b junior participating preferred stock, .001 par value; shares authorized — 45,000; shares issued and outstanding — none                                                                                     
  preferred stock: shares authorized - 5,000                                                                                     
  series b junior participating preferred stock, .001 par value; shares authorized - 45; shares issued and outstanding - none                                                                                     
  patents and licenses, net of accumulated amortization of 32,094 in 2006                                                                                     
  preferred stock: shares authorized - 5,000,000 series b junior participating preferred stock, .001 par value; shares authorized - 45,000; shares issued and outstanding - none                                                                                     
  receivables from collaborations – billed                                                                       5,005,000              
  receivables from collaborations – unbilled                                                                       15,743,000              
  patents and licenses                                                                       297,000 314,000 303,000  260,000 248,000 222,000        
  receivables from collaborations — billed                                                                        3,460,000 3,871,000            
  receivables from collaborations — unbilled                                                                        14,813,000 4,496,000            
  preferred stock: shares authorized — 5,000 series b junior participating preferred stock, .001 par value; shares authorized — 45; shares issued and outstanding — none                                                                                     
  patents and licenses, net of accumulated amortization of 32,094 in 2006 and 13,076 in 2005                                                                          290,694           
  preferred stock: shares authorized - 5,000,000 series b junior participating preferred stock, .001 par value; shares authorized - 45,000; shares issued and outstanding — none                                                                                     
  receivable from collaboration                                                                           3,139,000 1,975,000 630,000 30,000,000       
  stockholders' equity:                                                                                     
  series a convertible preferred stock, .01 par value; shares authorized – 1,800; shares issued and outstanding – none                                                                                     
  total stockholders' equity                                                                           30,022,000          
  total liabilities and stockholders' equity                                                                           80,198,000          
  series b junior participating preferred stock, .001 par value; shares authorized – 21.5; shares issued and outstanding – none                                                                                     
  securities held-to-maturity                                                                             25,422,000 21,103,572 21,738,000 23,812,000 18,988,000 14,334,631 9,144,000 7,118,000 
  patents and licenses, net of accumulated amortization of 13,076 in 2005 and 3,934 in 2004                                                                              187,635       
  preferred stock: shares authorized - 5,000,000                                                                                     
  series a convertible preferred stock, .01 par value; shares authorized - 1,800,000; shares issued and outstanding - none                                                                                     
  series b junior participating preferred stock, .001 par value; shares authorized - 45,000; shares issued and outstanding - none                                                                                     
  patents                                                                               284,000 268,000 258,000  242,000 195,000 
  series b junior participating preferred stock, .001 par value; shares authorized – 21.5; shares issued and outstanding - none                                                                                     
  patents and licenses, less accumulated amortization of 3,934 in 2004 and 955 in 2003                                                                                  248,586   
  series b junior participating preferred stock, .001 par value; shares authorized - 21,500; shares issued and outstanding - none                                                                                     
  series a convertible preferred stock, .01 par value; shares                                                                                     
  authorized - 1,800; shares issued and outstanding - none                                                                                     
  series b junior participating preferred stock, .001 par value; shares                                                                                     
  authorized - 21.5; shares issued and outstanding - none                                                                                     
  45,000; shares issued and outstanding -                                                                                     
  21,682 in 2004 and 17,871 in 2003                                                                                    217,000 

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