7Baggers

AnaptysBio, Inc
(NASDAQ:ANAB) 

ANAB stock logo

AnaptysBio, Inc., a clinical stage biotechnology company, engages in developing therapeutic product candidates for inflammation and immuno-oncology indications. The company's products include Imsidolimab, an IL-36R antibody that inhibits the interleukin-36 receptor for the treatment of various derma...

Founded: 2005
Full Time Employees: 89
Sector: Healthcare
Industry: Biotechnology

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At a glance:
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Income Statements:
Quarterly
Annual
    Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 
                                          
      collaboration revenue
    25,556,000 108,249,000 76,320,000 22,263,000 27,771,000 43,113,000 30,017,000 10,971,000 7,179,000 9,005,000 3,318,000 3,460,000 1,374,000 6,808,000 1,293,000 1,216,000 970,000 1,011,000 20,890,000 30,027,000 11,247,000 60,000,000   15,000,000 3,000,000  5,000,000   5,000,000   3,000,000  7,000,000   
      operating expenses:
                                          
      research and development
    33,991,000 25,559,000 31,407,000 37,824,000 41,180,000 42,589,000 42,212,000 41,997,000 37,042,000 33,525,000 30,878,000 32,923,000 34,957,000 23,374,000 22,064,000 20,844,000 22,516,000 26,776,000 22,221,000 25,314,000 24,185,000 21,567,000 19,542,000 17,948,000 20,968,000 21,426,000 29,931,000 27,350,000 20,631,000 15,920,000 17,883,000 10,583,000 11,810,000 7,606,000 6,697,000 7,205,000 7,935,000  
      general and administrative
    26,202,000 15,789,000 10,209,000 10,609,000 14,130,000 10,194,000 10,562,000 9,295,000 12,338,000 10,276,000 10,172,000 10,680,000 10,818,000 9,407,000 8,862,000 8,171,000 10,203,000 5,392,000 5,432,000 5,246,000 5,423,000 5,088,000 4,794,000 4,687,000 4,285,000 3,832,000 3,814,000 4,307,000 4,141,000 3,743,000 4,004,000 3,832,000 3,947,000 2,545,000 2,390,000 2,350,000 2,053,000  
      total operating expenses
    60,193,000 41,348,000 41,616,000 48,433,000 55,310,000 52,783,000 52,774,000 51,292,000 49,380,000 51,140,000 41,050,000 43,603,000 45,775,000 32,781,000 30,926,000 29,015,000 32,719,000 32,168,000 27,653,000 30,560,000 29,608,000 26,655,000 24,336,000 22,635,000 25,253,000 25,258,000 33,745,000 31,657,000 24,772,000 19,663,000 21,887,000 14,415,000 15,757,000 10,151,000 9,087,000 9,555,000 9,988,000  
      income from operations
    -34,637,000 66,901,000 34,704,000 -26,170,000 -27,539,000 -9,670,000 -22,757,000 -40,321,000 -42,201,000 -42,135,000 -37,732,000 -40,143,000 -44,401,000 -25,973,000 -29,633,000 -27,799,000 -31,749,000 -31,157,000 -6,763,000 -533,000 -18,361,000 33,345,000 -24,336,000 -22,635,000 -10,253,000 -22,258,000 -33,745,000 -26,657,000 -24,772,000 -19,663,000 -16,887,000 -14,415,000 -15,757,000 -7,151,000 -9,087,000 -2,555,000 -9,988,000  
      yoy
    25.77% -791.84% -252.50% -35.10% -34.74% -77.05% -39.69% 0.44% -4.95% 62.23% 27.33% 44.40% 39.85% -16.64% 338.16% 5115.57% 72.92% -193.44% -72.21% -97.65% 79.08% -249.81% -27.88% -15.09% -58.61% 13.20% 99.83% 84.93% 57.21% 174.97% 85.84% 464.19% 57.76%      
      qoq
    -151.77% 92.78% -232.61% -4.97% 184.79% -57.51% -43.56% -4.45% 0.16% 11.67% -6.01% -9.59% 70.95% -12.35% 6.60% -12.44% 1.90% 360.70% 1168.86% -97.10% -155.06% -237.02% 7.51% 120.76% -53.94% -34.04% 26.59% 7.61% 25.98% 16.44% 17.15% -8.52% 120.35% -21.31% 255.66% -74.42%   
      other income, net:
                                          
      interest income
    2,653,000 2,508,000 2,924,000 3,654,000 4,413,000 5,263,000 5,324,000 4,623,000 4,584,000 4,880,000 4,854,000 4,653,000 4,486,000 3,839,000 2,262,000 1,107,000 342,000 68,000 64,000 104,000 195,000 376,000 625,000 1,061,000 1,897,000 2,282,000 2,757,000 2,957,000 2,988,000 2,834,000 1,369,000 1,297,000 1,185,000      
      non-cash interest expense for the sale of future royalties
    -20,859,000 -19,711,000 -22,515,000 -19,606,000 -18,061,000 -17,404,000 -15,413,000 -10,953,000 -6,317,000 -4,958,000 -4,431,000 -4,358,000 -4,336,000 -4,251,000 -6,135,000 -5,868,000 -4,854,000                      
      other income
    -1,000 -3,000  3,531,000 1,902,000 21,000 -5,000    1,000 3,000 -4,000 -4,000 4,000 6,000 6,000 1,000 33,000  3,000 -75,000 -56,000 26,000 94,000 -109,000 144,000 -41,000 7,000 8,000 -40,000 -64,000 -63,000 -877,000 449,000 310,000 347,000  
      total other expense
    -18,207,000 -10,939,500 -19,591,000 -12,421,000 -11,746,000                                  
      income before income taxes
    -52,844,000 49,695,000 15,113,000 -38,591,000 -39,285,000 -21,790,000 -32,851,000 -46,651,000              33,646,000 -23,767,000 -21,548,000 -8,262,000 -20,285,000 -31,084,000 -24,022,000 -22,097,000          
      provision for income taxes
    -40,000 -20,750  -39,000 -44,000 -2,250  -9,000                  22,000 51,000 60,000 19,000          
      net income
    -52,884,000 49,614,000 15,113,000 -38,630,000 -39,329,000 -21,784,000 -32,851,000 -46,660,000 -43,936,000 -42,211,000 -37,308,000 -39,845,000 -44,255,000 -26,413,000 -33,502,000 -32,554,000 -36,255,000 -32,538,000 -6,666,000 -429,000 -18,163,000 33,646,000 -23,767,000 -21,548,000 -8,262,000 -20,263,000 -31,033,000 -23,962,000 -22,078,000 -16,994,000 -15,958,000 -13,618,000 -15,086,000 -6,861,000 -9,090,000 -2,684,000 -11,435,000  
      yoy
    34.47% -327.75% -146.00% -17.21% -10.49% -48.39% -11.95% 17.10% -0.72% 59.81% 11.36% 22.40% 22.07% -18.82% 402.58% 7488.34% 99.61% -196.71% -71.95% -98.01% 119.84% -266.05% -23.41% -10.07% -62.58% 19.24% 94.47% 75.96% 46.35% 147.69% 75.56% 407.38% 31.93%      
      qoq
    -206.59% 228.29% -139.12% -1.78% 80.54% -33.69% -29.59% 6.20% 4.09% 13.14% -6.37% -9.96% 67.55% -21.16% 2.91% -10.21% 11.42% 388.12% 1453.85% -97.64% -153.98% -241.57% 10.30% 160.81% -59.23% -34.70% 29.51% 8.53% 29.92% 6.49% 17.18% -9.73% 119.88% -24.52% 238.67% -76.53%   
      other comprehensive loss:
                                          
      unrealized loss on available-for-sale securities
    -122,000                                      
      comprehensive loss
    -53,006,000   -38,797,000 -39,473,000 -22,238,000 -31,677,000 -46,451,000 -43,763,000 -40,658,000 -36,047,000 -40,189,000 -42,276,000 -25,652,000 -35,648,000 -33,981,000 -38,267,000 -32,760,000 -6,690,000 -494,000 -18,270,000 33,383,000 -24,261,000 -21,940,000 -7,455,000 -20,405,000 -31,127,000 -23,592,000 -21,651,000 -16,676,000 -15,822,000 -13,494,000 -15,887,000 -7,244,000 -9,074,000  -11,448,000  
      net loss per common share:
                                          
      basic and diluted
    -1,840   -1,340 -1,280 -660 -1,140 -1,710 -1,640 -1,590 -1,410 -1,500 -1,580 -930 -1,180 -1,150 -1,310 -1,190 -240 -20 -660 1,230 -870 -790 -300 -750 -1,150 -890 -820 -640 -660 -570 -630    -750  
      weighted-average number of shares outstanding:
                                          
      basic and diluted
    28,691,000 28,758,000  28,810,000 30,644,000 28,382,000 28,893,000 27,356,000 26,801,000 26,924,000 26,546,000 26,629,000 27,953,000 28,165,000 28,289,000 28,204,000 27,713,000 27,431,000 27,436,000 27,391,000 27,361,000 27,302,000 27,316,000 27,279,000 27,264,000 27,059,000 27,058,000 27,026,000 26,981,000 24,673,000 24,146,000 23,932,000 23,801,000 19,782,000   15,295,000  
      unrealized gain on available for sale securities
     -71,000 53,000 -167,000 -144,000 -454,000 1,174,000 209,000 173,000 1,553,000 1,261,000 -344,000 1,979,000                          
      comprehensive income
     -15,776,000 15,166,000                                 -2,730,000   
      net income per common share:
                                          
      basic
     -540 540                                 -130   
      diluted
     -540 520                                 -130   
      weighted-average number of shares outstanding:
                                          
      basic
      27,833,000                                20,382,000 20,271,000   
      diluted
      29,018,000                                20,382,000 20,271,000   
      total other income
         -12,120,000 -10,094,000 -6,330,000 -1,735,000 -80,000 424,000 298,000 146,000 -416,000 -3,869,000 -4,755,000 -4,506,000 -1,381,000 97,000 104,000 198,000 301,000 569,000 1,087,000 1,991,000 1,973,000 2,661,000 2,635,000 2,675,000 2,477,000 929,000 797,000 671,000 290,000 -3,000 -129,000 -1,447,000  
      other expense
            -2,000                              
      unrealized loss on available for sale securities
                 761,000 -2,146,000 -1,427,000 -2,012,000 -49,000 -24,000              -801,000   -46,000 -13,000  
      unrealized income on available for sale securities
                       -65,000 -107,000         373,000 136,000 124,000  -10,750 16,000    
      interest expense
                             -200,000 -240,000 -281,000 -320,000 -365,000 -400,000 -436,000 -451,000 -456,000 -452,000 -439,000 -428,000  
      other comprehensive income:
                                          
      unrealized income on available for sale securities, net of tax of 0, (25), 0 and 189, respectively
                         -19,750 -494,000                
      unrealized income on available for sale securities, net of tax of 0, 99, 0 and 214, respectively
                           -392,000               
      unrealized income on available for sale securities, net of tax of 0 and 115, respectively
                            807,000              
      unrealized income on available for sale securities, net of tax of (25), 0, 189 and 0, respectively
                             175,750 -94,000            
      unrealized income on available for sale securities, net of tax of 99, 0, 214 and 0, respectively
                               370,000           
      unrealized income on available for sale securities, net of tax of 115 and 0, respectively
                                427,000          
      change in fair value of liability for preferred stock warrants
                                        -1,366,000  
      other comprehensive income
                                 -28,750 136,000 124,000  -10,750 16,000    
      other comprehensive loss
                                    -801,000   -46,000 -13,000  
      net income attributed to participating securities
                                          
      net loss attributed to common stockholders
                                     -5,802,250 -9,090,000    
      net loss per common share:
                                          
      basic
                                     -310 -450    
      diluted
                                     -310 -450    
      net income attributed to common stockholders
                                       -2,684,000   
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 
                                            
        assets
                                            
        current assets:
                                            
        cash and cash equivalents
      248,469,000 238,196,000 109,833,000 44,298,000 98,637,000 123,080,000 191,581,000 71,821,000 53,695,000 35,965,000 26,295,000 35,206,000 94,562,000 71,308,000 58,547,000 71,701,000 166,412,000 495,729,000 336,328,000 332,254,000 284,148,000 250,456,000 209,154,000 221,172,000 165,317,000 171,017,000 182,898,000 146,552,000 105,853,000 113,596,000 293,408,000 57,057,000 69,474,000 81,189,000 26,669,000 30,752,000 96,754,000 51,232,000 
        receivables from collaborative partners
      25,747,000 33,850,000 75,685,000 21,418,000 17,884,000 40,765,000 12,195,000 9,007,000 7,089,000 6,851,000 3,269,000 3,182,000 1,523,000 1,419,000 1,180,000 1,033,000 921,000 876,000 761,000                    
        short-term investments
      37,986,000 73,442,000 139,123,000 221,412,000 241,299,000 262,293,000 238,536,000 278,983,000 300,970,000 354,939,000 386,752,000 394,280,000 336,589,000 369,933,000 384,419,000 370,450,000 339,209,000 52,368,000 37,736,000 58,597,000 96,212,000 143,197,000 129,192,000 156,706,000 197,166,000 203,210,000 238,104,000 275,664,000 309,812,000 313,486,000 200,406,000 210,852,000 178,691,000 167,218,000 89,053,000 75,607,000 6,742,000  
        prepaid expenses and other current assets
      3,907,000 4,762,000 6,009,000 4,778,000 5,292,000 5,738,000 6,369,000 7,539,000 10,666,000 9,080,000 11,684,000 5,867,000 4,480,000 4,545,000 6,298,000 9,625,000 5,869,000 4,903,000 11,759,000 6,508,000 5,464,000 2,908,000 7,468,000 6,638,000 3,572,000 3,506,000 3,595,000 3,772,000 6,102,000 6,960,000 4,035,000 3,758,000 2,170,000 2,688,000 3,119,000 3,852,000 1,694,000 1,633,000 
        total current assets
      316,109,000 350,250,000 330,650,000 291,906,000 363,112,000 431,876,000 448,681,000 367,350,000 372,420,000 406,835,000 428,000,000 438,535,000 437,154,000 447,205,000 450,444,000 452,809,000 512,411,000 553,876,000 386,644,000 398,061,000 387,131,000 396,561,000 345,814,000 384,516,000 371,055,000 377,733,000 424,597,000 430,988,000 421,942,000 434,216,000 503,022,000 271,819,000 251,945,000 252,696,000 120,327,000 115,848,000 110,155,000 58,208,000 
        property and equipment
      1,280,000 1,370,000 1,500,000 1,628,000 1,741,000 1,849,000 1,728,000 1,833,000 1,954,000 2,098,000 2,254,000 2,023,000 1,982,000 2,089,000 1,972,000 2,059,000 2,162,000 2,283,000 2,413,000 2,488,000 1,754,000 1,783,000 1,585,000 1,495,000 1,610,000 1,618,000 1,695,000 1,481,000 1,584,000 1,445,000 1,344,000 1,086,000 659,000 665,000 513,000 543,000 569,000 471,000 
        operating lease right-of-use assets
      12,039,000 12,519,000 12,994,000 13,464,000 13,923,000 14,383,000 14,839,000 15,291,000 15,732,000 16,174,000 16,613,000 17,047,000 17,471,000 17,898,000 18,320,000 18,739,000 19,147,000 19,558,000 19,778,000 20,278,000                   
        other long-term assets
      256,000 256,000 256,000 256,000 256,000 256,000 256,000 256,000 256,000 256,000 256,000 256,000 256,000 256,000 256,000 256,000 256,000 256,000 258,000 258,000 477,000 602,000 1,114,000 1,354,000 1,293,000 1,481,000 1,735,000 1,913,000 2,089,000 148,000 79,000 322,000 289,000      
        total assets
      329,684,000 364,395,000 353,098,000 335,250,000 422,053,000 483,834,000 493,418,000 427,376,000 405,835,000 452,389,000 487,326,000 517,100,000 551,792,000 610,383,000 618,503,000 603,848,000 625,171,000 643,070,000 424,335,000 426,569,000 396,418,000 416,552,000 384,750,000 401,746,000 424,233,000 435,197,000 451,505,000 480,149,000 494,226,000 508,997,000 523,121,000 306,017,000 314,837,000 329,364,000 121,945,000 130,409,000 131,111,000 62,180,000 
        liabilities and stockholders’ equity
                                            
        current liabilities:
                                            
        accounts payable
      7,517,000 3,871,000 2,893,000 3,329,000 6,123,000 4,002,000 3,592,000 4,890,000 4,582,000 4,698,000 6,521,000 4,761,000 3,168,000 2,784,000 3,006,000 1,587,000 2,481,000 1,741,000 5,717,000 4,103,000 2,452,000 4,217,000 5,484,000 6,289,000 8,571,000 16,237,000 10,522,000 10,921,000 9,072,000 5,443,000 6,180,000 4,426,000 2,416,000 2,323,000 2,557,000 3,724,000 2,546,000 2,278,000 
        accrued expenses
      32,065,000 32,674,000 33,171,000 30,197,000 35,952,000 39,501,000 38,401,000 33,680,000 25,903,000 30,967,000 30,916,000 35,164,000 30,956,000 21,633,000 16,453,000 16,714,000 15,763,000 12,853,000 14,075,000 15,958,000 11,826,000 15,262,000 18,139,000 12,916,000 13,781,000 11,052,000 15,286,000 14,102,000 8,400,000 8,761,000 7,145,000 4,837,000 4,405,000 4,875,000 3,604,000 3,230,000 4,330,000 3,429,000 
        current portion of operating lease liability
      2,120,000 2,080,000 2,040,000 2,001,000 1,962,000 1,925,000 1,887,000 1,850,000 1,813,000 1,777,000 1,741,000 1,706,000 1,671,000 1,637,000 1,604,000 1,570,000 1,537,000 1,505,000 1,097,000 555,000                   
        total current liabilities
      41,702,000 38,625,000 38,104,000 35,527,000 44,037,000 45,428,000 43,880,000 40,420,000 32,298,000 37,442,000 39,178,000 41,631,000 35,795,000 26,054,000 21,063,000 19,871,000 19,781,000 16,099,000 20,889,000 20,616,000 14,475,000 19,821,000 24,474,000 20,130,000 23,250,000 29,535,000 29,730,000 30,623,000 24,754,000 21,836,000 20,873,000 16,790,000 14,343,000 14,090,000 11,174,000 10,079,000 8,126,000 5,708,000 
        liability related to sale of future royalties
      263,742,000 276,528,000 331,844,000 331,361,000 330,382,000 353,426,000 350,564,000 361,981,000 310,184,000 310,807,000 311,272,000 310,073,000 307,516,000 304,413,000 301,586,000 261,019,000 255,584,000 251,093,000                     
        operating lease liability, net of current portion
      11,493,000 12,032,000 12,566,000 13,095,000 13,613,000 14,112,000 14,607,000 15,096,000 15,575,000 16,037,000 16,493,000 16,946,000 17,388,000 17,813,000 18,235,000 18,652,000 19,059,000 19,450,000 19,838,000 20,222,000                   
        stockholders’ equity:
                                            
        preferred stock, 0.001 par value...
                                            
        common stock, 0.001 par value...
      29,000 28,000 28,000 28,000 30,000 30,000 30,000 27,000 27,000 27,000 27,000 27,000 27,000 29,000 28,000 28,000 28,000 28,000 27,000 27,000 27,000 27,000 27,000 27,000 27,000 27,000 27,000 27,000 27,000 27,000 27,000 24,000 24,000 24,000 20,000 20,000 20,000 3,000 
        additional paid-in capital
      838,307,000                      657,560,000                
        accumulated other comprehensive loss
      -146,000       -415,000 -624,000 -797,000 -2,350,000 -3,611,000 -3,267,000 -5,246,000 -6,007,000 -3,861,000 -2,434,000 -422,000 -200,000 -176,000 -111,000         -223,000 -541,000 -677,000 -801,000 -426,000 -43,000 -59,000   
        accumulated deficit
      -825,443,000 -772,559,000 -822,173,000 -837,286,000 -798,656,000 -759,327,000 -737,543,000 -704,692,000 -658,032,000 -614,096,000 -571,885,000 -534,577,000 -494,732,000 -450,477,000 -424,064,000 -390,562,000 -358,008,000 -321,753,000 -289,215,000 -282,549,000 -282,120,000 -263,957,000 -297,603,000 -273,836,000 -252,288,000 -244,026,000 -223,763,000 -192,730,000 -168,768,000 -146,690,000 -129,696,000 -113,738,000 -100,120,000 -85,034,000 -78,173,000 -69,083,000 -66,399,000 -54,923,000 
        total stockholders’ equity
      12,747,000 37,210,000   34,021,000 70,868,000 84,367,000 9,879,000 47,778,000 88,103,000 120,383,000 148,450,000 191,093,000 262,103,000 277,619,000 304,306,000 330,747,000 356,428,000 383,608,000 385,731,000 381,943,000 396,731,000 360,243,000 381,436,000 400,564,000 405,008,000 420,892,000 448,421,000 468,155,000 486,365,000 499,677,000 284,979,000 294,527,000 307,581,000 101,355,000 109,175,000 110,115,000  
        total liabilities and stockholders’ equity
      329,684,000 364,395,000  335,250,000 422,053,000 483,834,000 493,418,000 427,376,000 405,835,000 452,389,000 487,326,000 517,100,000 551,792,000 610,383,000 618,503,000 603,848,000 625,171,000 643,070,000 424,335,000 426,569,000 396,418,000 416,552,000 384,750,000 401,746,000 424,233,000  451,505,000 480,149,000 494,226,000          
        long-term investments
        7,698,000 27,996,000 43,021,000 35,470,000 27,914,000 42,646,000 15,473,000 27,026,000 40,203,000 59,239,000 94,929,000 142,935,000 147,511,000 129,985,000 91,195,000 67,097,000 15,242,000 5,484,000 7,056,000 17,546,000 36,177,000 14,321,000 50,215,000 54,305,000 23,418,000 45,707,000 68,551,000 73,128,000 18,616,000 32,730,000 61,884,000 75,897,000 999,000 13,912,000 20,327,000  
        additional paid in capital
       809,765,000 792,682,000 792,531,000 832,486,000 829,860,000 821,121,000 714,959,000 706,407,000 702,969,000 694,591,000 686,611,000 689,065,000 717,797,000 707,662,000 698,701,000 691,161,000 678,575,000 672,996,000 668,429,000 664,147,000 660,665,000  654,492,000 651,680,000 648,669,000 644,148,000 640,550,000 636,692,000 633,251,000 629,887,000 399,370,000 395,424,000 393,017,000 179,551,000 178,297,000 176,507,000 16,672,000 
        accumulated other comprehensive gain
       -24,000 47,000 -6,000 161,000 305,000 759,000                                
        stockholders’ (deficit) equity:
                                            
        total stockholders’ (deficit) equity
        -29,416,000 -44,733,000                                   
        total liabilities and stockholders’ (deficit) equity
        353,098,000                                    
        long-term restricted cash
                                            
        short-term restricted cash
                        60,000                    
        receivable from collaborative partners
                         642,000 1,247,000    5,000,000   5,000,000   5,000,000       1,225,000 
        restricted cash
                         60,000 60,000 60,000 60,000 60,000 60,000 60,000 60,000 60,000 60,000 60,000 60,000 60,000 60,000 60,000 60,000 60,000 60,000 60,000 
        other current liabilities
                          197,000 342,000 851,000 925,000 898,000 871,000 845,000 819,000 794,000 58,000 48,000 27,000 22,000 17,000 13,000   1,000 
        notes payable, current portion
                               1,375,000 3,077,000 4,781,000 6,488,000 7,574,000 7,500,000 7,500,000 7,500,000 6,875,000 5,000,000 3,125,000 1,250,000  
        other long-term liabilities
                            33,000 180,000 419,000 654,000 883,000 1,105,000 1,317,000          
        accumulated other comprehensive income
                           -4,000 259,000 753,000 1,145,000 338,000 480,000 574,000 204,000        -13,000  
        australian tax incentive receivable
                                  175,000 174,000 173,000 152,000 1,610,000 1,601,000 1,486,000 5,637,000 4,965,000 4,118,000 
        total liabilities, preferred stock and stockholders’ equity
                               435,197,000    508,997,000 523,121,000 306,017,000 314,837,000      
        liabilities, preferred stock andstockholders’ equity
                                            
        notes payable, net of current portion
                                   625,000 2,409,000 4,120,000 5,834,000 7,553,000 9,269,000 10,987,000 12,709,000 13,809,000 
        deferred rent
                                   171,000 162,000 128,000 133,000 140,000 147,000 168,000 161,000 154,000 
        liabilities, preferred stock and stockholders’ equity
                                            
        long-term vendor deposits
                                       46,000 46,000 46,000   
        deferred financing costs
                                           3,441,000 
        liabilities, convertible preferred stock andstockholders’ equity
                                            
        preferred stock warrant liabilities
                                           3,241,000 
        commitments and contingencies
                                            
        series b convertible preferred stock, 0.001 par value...
                                           28,220,000 
        series c convertible preferred stock, 0.001 par value...
                                           6,452,000 
        series c-1 convertible preferred stock, 0.001 par value...
                                           2,156,000 
        series d convertible preferred stock, 0.001 par value...
                                           40,688,000 
        stockholders’ equity
                                            
        total liabilities, convertible preferred stock and stockholders’ equity
                                       329,364,000 121,945,000 130,409,000 131,111,000  
        liabilities, convertible preferred stock and stockholders’ deficit
                                            
        deferred revenue
                                            
        income taxes payable
                                            
        stockholders’ deficit:
                                            
        total stockholders’ deficit
                                           -38,248,000 
        total liabilities, convertible preferred stock and stockholders’ deficit
                                           62,180,000 
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 
                                             
          cash flows from operating activities:
                                             
          net loss
        -52,884,000 49,614,000 15,113,000 -38,630,000 -39,329,000 -21,784,000 -32,851,000 -46,660,000 -43,936,000 -42,211,000 -37,308,000 -39,845,000 -44,255,000   -32,554,000 -36,255,000 -32,538,000 -6,666,000 -429,000 -18,163,000 33,646,000 -23,767,000 -21,548,000 -8,262,000 -20,263,000 -31,033,000 -23,962,000 -22,078,000 -16,994,000 -15,958,000 -13,618,000 -15,086,000    -11,435,000 
          adjustments to reconcile net loss to net cash from operating activities:
                                             
          depreciation and amortization
        130,000 131,000 140,000 142,000 146,000 145,000 144,000 154,000 163,000 165,000 158,000 163,000 166,000 184,000 166,000 163,000 162,000 165,000 169,000 160,000 125,000 144,000 138,000 137,000 140,000 140,000 135,000 124,000 115,000 106,000 91,000 64,000 54,000 47,000 46,000 51,000 39,000 
          stock-based compensation
        14,218,000 8,506,000 9,157,000 9,239,000 9,170,000 8,184,000 8,189,000 7,544,000 10,131,000 8,111,000 7,807,000 8,427,000 8,860,000 6,685,000 6,271,000 6,658,000 7,742,000 3,978,000 4,364,000 3,690,000 3,315,000 2,978,000 2,805,000 2,741,000 2,975,000 2,757,000 3,144,000 3,643,000 2,867,000 2,621,000 2,532,000 2,548,000 2,260,000 1,132,000 942,000 1,438,000 866,000 
          accretion/amortization of investments
        -8,000 -340,000 -1,130,000 -1,597,000 -1,667,000 -2,302,000 -2,566,000 -2,477,000 -2,968,000 -3,154,000 -2,993,000 -2,183,000 -2,191,000 -1,723,000   161,000 100,000 100,000 126,000 167,000 222,000 178,000 69,000 -8,000 -184,000 -523,000           
          amortization of right-of-use assets – operating
        480,000 475,000 470,000 459,000 460,000 456,000 452,000 441,000 442,000 439,000 434,000 424,000 427,000 422,000 419,000 408,000 411,000 220,000 500,000                   
          non-cash interest expense for sale of future royalties
        20,859,000                                     
          changes in operating assets and liabilities:
                                             
          receivables from collaborative partners
        8,103,000 41,835,000 -54,267,000 -3,534,000 22,881,000 -28,570,000 -3,188,000 -1,918,000 -238,000 -3,582,000 -87,000 -1,659,000 -104,000 -239,000 -147,000 -112,000 -45,000 -115,000                    
          prepaid expenses and other assets
        1,501,000 971,000 -303,000 414,000 530,000 299,000 1,405,000 3,065,000 -1,566,000 2,843,000 -5,796,000 -1,292,000 51,000 1,705,000 2,821,000 -4,118,000 -1,221,000 6,740,000 -5,306,000 -959,000 -2,276,000 5,008,000 -424,000 -2,711,000 233,000 253,000 490,000 2,649,000 -1,214,000 -3,785,000 -217,000 -1,574,000 388,000 -304,000 909,000 -2,347,000 -143,000 
          accounts payable and other liabilities
        -17,819,000 -22,412,000 -18,561,000 -22,320,000 -24,034,000 -40,047,000 3,364,000 8,018,000 -5,172,000 -1,498,000 -2,702,000 6,605,000 8,533,000 4,832,000 1,257,000 75,000 3,536,000 -5,321,000 -191,000 5,897,000 -5,125,000 -4,446,000 4,057,000 -3,298,000 -5,190,000 1,319,000 520,000 7,584,000 5,076,000 1,137,000 3,849,000 2,255,000 -158,000 1,137,000 -1,019,000 1,418,000 682,000 
          deferred income
            3,544,000                                 
          operating lease liabilities
        -499,000 -494,000 -490,000 -479,000 -462,000 -457,000 -452,000 -442,000 -426,000 -420,000 -418,000 -407,000 -391,000 -389,000 -383,000 -374,000 -359,000 20,000 158,000                   
          net cash from operating activities
        -25,919,000 97,997,000 -27,356,000 -40,244,000 -10,700,000 -66,672,000 -10,090,000 -21,322,000 -37,253,000 -34,349,000 -36,474,000 -25,409,000 -24,568,000 -10,685,000 -17,747,000 -24,147,000 -21,014,000 -25,301,000 -7,006,000 9,591,000 -23,204,000 37,578,000 -17,013,000 -19,610,000 -15,112,000 -15,805,000 -22,096,000 -15,517,000 -16,099,000 -12,290,000 -14,860,000 -8,878,000 -12,478,000 -4,810,000 -3,888,000 -2,643,000 -8,097,000 
          capital expenditures
        -17,000 -1,000 -12,000 -39,000 -35,000 -263,000 -35,000 -33,000 -27,000 -280,000 -162,000 -190,000 -175,000 -175,000 -50,000 -78,000 -55,000 -14,000 -172,000 -863,000 -317,000 -311,000 -88,000 -83,000 -87,000 -104,000 -280,000 -241,000 -180,000 -206,000 -321,000 -304,000 -232,000 -124,000 -13,000 -68,000 -85,000 
          free cash flows
        -25,936,000 97,996,000 -27,368,000 -40,283,000 -10,735,000 -66,935,000 -10,125,000 -21,355,000 -37,280,000 -34,629,000 -36,636,000 -25,599,000 -24,743,000 -10,860,000 -17,797,000 -24,225,000 -21,069,000 -25,315,000 -7,178,000 8,728,000 -23,521,000 37,267,000 -17,101,000 -19,693,000 -15,199,000 -15,909,000 -22,376,000 -15,758,000 -16,279,000 -12,496,000 -15,181,000 -9,182,000 -12,710,000 -4,934,000 -3,901,000 -2,711,000 -8,182,000 
          cash flows from investing activities:
                                             
          purchase of investments
                                             
          sales and maturities of investments
        35,000,000 73,501,000 122,950,000 90,650,000 137,429,000 91,749,000 110,000,000 146,743,000 127,640,000 115,765,000 100,845,000 98,744,000 134,126,000 149,250,000 147,746,000 101,400,000 9,620,000 25,500,000 27,744,000 42,320,000 63,284,000 42,264,000 74,445,000 88,411,000 84,851,000 80,905,000 102,879,000 110,667,000 89,600,000 57,598,000 58,520,000 55,450,000 34,581,000 27,271,000    
          purchases of property and equipment
        -17,000 -1,000 -12,000 -39,000 -35,000 -263,000 -35,000 -33,000 -27,000 -280,000 -162,000 -190,000 -175,000 -175,000 -50,000 -78,000 -55,000 -14,000 -172,000 -863,000 -317,000 -311,000 -88,000 -83,000 -87,000 -104,000 -280,000 -241,000 -180,000 -206,000 -321,000 -304,000 -232,000 -124,000 -13,000 -68,000 -85,000 
          net cash from investing activities
        34,983,000 73,500,000 103,282,000 36,403,000 14,847,000 -29,396,000 58,620,000 -2,442,000 68,616,000 49,178,000 30,635,000 -20,455,000 85,396,000 21,497,000 -32,434,000 -70,996,000 -312,912,000 -66,694,000 10,839,000 37,961,000 56,729,000 3,598,000 4,732,000 75,394,000 10,751,000 4,035,000    -166,150,000 24,615,000 -3,062,000 2,146,000 -153,057,000 -495,000 -62,421,000 -27,085,000 
          cash flows from financing activities:
                                             
          proceeds from issuance of common stock
        14,021,000 12,212,000 336,000 1,423,000 290,000 555,000 4,128,000 979,000 811,000 264,000 160,000 783,000 1,265,000 3,419,000 2,699,000 865,000 4,844,000                     
          repurchase and retirements of common stock
          -9,720,000 -51,098,000 -4,424,000      -12,474,000 -37,526,000                         
          payment for net share settlement of equity awards
         -1,451,000 -7,504,000                             
          principal repayment of liability for sale of future royalties
        -12,812,000 -51,962,000 -1,007,000 -823,000 -23,005,000                                 
          net cash from financing activities
        1,209,000 -43,134,000 -10,391,000 -50,498,000 -28,590,000 27,567,000 71,230,000 41,890,000 -13,633,000 -5,159,000 -3,072,000 -13,492,000 -37,574,000  37,027,000 432,000 4,609,000  241,000 554,000 167,000 126,000 263,000 71,000 -1,339,000 -111,000 -1,421,000 -1,660,000 -1,301,000 -1,372,000 226,596,000 -477,000 -1,383,000 212,387,000 300,000 -938,000 80,704,000 
          net increase in cash and cash equivalents
        10,273,000 128,363,000 65,535,000 -54,339,000 -24,443,000 -68,501,000 119,760,000 18,126,000 17,730,000    23,254,000  -13,154,000 -94,711,000 -329,317,000                     
          cash and cash equivalents, beginning of period
        238,196,000 123,080,000 35,965,000                             
          cash and cash equivalents, end of period
        248,469,000 128,363,000 65,535,000 -54,339,000 98,637,000 -68,501,000 119,760,000 18,126,000 53,695,000                             
          supplemental disclosure of cash flow information
                                             
          interest portion of repayment for sale of future royalties
        20,833,000 23,065,000 21,025,000 17,804,000 18,100,000                                 
          state income taxes paid
        40,000                                     
          non-cash investing and financing activities:
                                             
          amounts accrued for property and equipment
        23,000    11,000 3,000    -271,000 227,000 14,000 38,000 126,000   19,000 20,000 -78,000 31,000 58,000 114,000 140,000 -61,000 86,000 -41,000 68,000 -219,000 233,000 -1,000 -34,000 187,000 7,000 179,000 3,000 -43,000 52,000 
          amounts accrued for repurchase of common stock
                                             
          receivable related to issuance of common stock, upon exercise of stock options
        304,000 -423,000        -8,000 -43,000 32,000 -9,000                       
          proceeds from public offerings, net of underwriters' fees
                                            
          proceeds from the sale of future royalties
                                          
          payments for repurchase of common stock
                                             
          payments for offering costs
             -122,000                          -280,000 -102,000 -12,000 -1,086,000 -399,000 
          payments for issuance costs related to the sale of future royalties
                                             
          non-cash interest expense
          22,515,000 19,606,000 18,061,000  15,413,000 10,953,000 6,317,000 4,958,000 4,431,000 4,358,000 4,336,000 4,251,000 6,135,000 5,868,000 4,854,000         173,000 171,000 168,000 164,000 165,000 164,000 161,000 156,000 159,000 157,000   
          purchases of investments
          -19,656,000 -54,208,000 -122,547,000  -51,345,000 -149,152,000 -58,997,000  -70,048,000 -119,009,000 -48,555,000  -180,130,000 -172,318,000 -322,477,000  -16,748,000                   
          proceeds from public offerings, net of underwriters’ fees
                                             
          payments for debt issuance costs
              -67,000    -43,000  -288,000 -2,000                     
          income taxes paid
          39,000 5,000                                 
          amounts accrued for repurchases of common stock
          74,000 -479,000 959,000      -13,000 -818,000 1,290,000                         
          amounts accrued for offering costs
                                         -178,000   1,290,000 
          amounts accrued for issuance costs related to the sale of future royalties
                     56,000 -104,000 128,000                     
          repayment of liability for sale of future royalties
              -26,830,000 -9,053,000 -6,940,000 -5,423,000 -3,232,000 -1,801,000 -1,270,000 -1,424,000 -384,000 -433,000 -233,000                     
          gain on disposal of property and equipment
                                             
          proceeds from the sale of property and equipment
                                            
          net increase in cash, cash equivalents, and restricted cash
                         159,341,000 4,074,000 48,106,000 33,692,000 41,302,000 -12,018,000   -11,881,000 36,346,000   -179,812,000   -11,715,000    45,522,000 
          cash, cash equivalents and restricted cash, beginning of period
                 71,308,000 495,729,000 250,516,000 171,077,000 113,656,000 81,249,000 51,292,000 
          cash, cash equivalents and restricted cash, end of period
                 9,670,000 -8,911,000 -59,356,000 94,562,000 12,761,000 -13,154,000 -94,711,000 166,412,000 159,341,000 4,074,000 48,106,000 284,208,000 41,302,000 -12,018,000 55,855,000 165,377,000 -11,881,000 36,346,000 40,699,000 105,913,000 -179,812,000 236,351,000 -12,417,000 69,534,000 54,520,000 -4,083,000 -66,002,000 96,814,000 
          leased assets obtained in exchange for operating lease liabilities
                                           
          net decrease in cash and cash equivalents
                  -8,911,000                           
          loss on disposal of property and equipment, net of gain on lease termination
                                             
          payments on notes payable
                             -1,375,000 -1,875,000 -1,875,000 -1,875,000 -1,875,000 -1,875,000 -1,875,000 -1,875,000 -1,250,000     
          net cash provided (used in) by financing activities
                                             
          interest paid
                             4,000 40,000 83,000 129,000 172,000 208,000 250,000 288,000 297,000 327,000 293,000 191,000 278,000 
          net income
                                          -9,090,000   
          adjustments to reconcile net income to net cash from operating activities:
                                             
          australian tax incentive receivable
                                 175,000 -1,000 -1,000 -21,000 1,458,000 -9,000 -115,000 4,151,000 -672,000 -847,000 
          proceeds from issuance of common stock, upon the exercise of stock options
                          241,000 554,000 167,000 126,000 263,000 71,000 36,000 1,764,000 454,000 215,000 574,000 731,000 669,000 1,397,000 72,000 165,000 311,000 148,000 355,000 
          receivable from collaborative partners
                           605,000 -1,247,000    -5,000,000         1,225,000 
          acquisition of investments
                            -6,238,000 -38,355,000 -69,625,000 -12,934,000 -74,013,000 -76,766,000 -42,736,000 -52,550,000 -79,763,000 -223,542,000 -33,584,000 -58,208,000 -32,203,000 -180,204,000 -21,348,000 -62,353,000 -27,000,000 
          income taxes
                                             
          proceeds from issuance of common stock, upon the exercise of warrants
                                     1,000 75,000 1,000 535,000 
          net decrease in cash, cash equivalents, and restricted cash
                                -5,700,000    -7,743,000      -4,083,000   
          change in fair value of liability for preferred stock warrants
                                         1,366,000 
          reclassification of warrants to equity
                                         4,607,000 
          proceeds for offering costs
                                             
          net from investing activities
                                             
          accretion of discount on investments
                                    -1,028,000         
          net provided by investing activities
                                    9,657,000         
          loss from investments
                                     -678,000   -83,000     
          loss on disposal of property and equipment
                                             
          deferred revenue
                                             
          proceeds from debt
                                             
          fair value of warrants issued with debt
                                             
          income from investments
                                         -5,000    
          income taxes payable
                                             
          proceeds from the issuance of preferred stock, net of issuance cost
                                             
          noncash investing and financing activities:
                                             
          proceeds from initial public offering, net of underwriters fees
                                          80,213,000 
          noncash interest expense
                                            150,000 
          restricted cash
                                             
          proceeds from sale of property and equipment
                                             
          proceeds from the issuance of preferred stock, net of issuance costs
                                             
          payments for deferred offering costs
                                             
          amounts accrued for deferred financing costs
                                             
          conversion of convertible promissory notes payable to related parties into shares of series c-1 preferred stock