AnaptysBio, Inc(NASDAQ:ANAB)

AnaptysBio, Inc., a clinical stage biotechnology company, engages in developing therapeutic product candidates for inflammation and immuno-oncology indications. The company's products include Imsidolimab, an IL-36R antibody that inhibits the interleukin-36 receptor for the treatment of various derma...
Website: http://www.anaptysbio.com
Founded: 2005
Full Time Employees: 89
Sector: Healthcare
Industry: Biotechnology
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At a glance:
Bull Thesis:
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Income Statements:
Quarterly
Annual
| Unit: USD | 2026-03-31 | 2025-12-31 | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2017-12-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | 2016-12-31 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
collaboration revenue | 25,556,000 | 108,249,000 | 76,320,000 | 22,263,000 | 27,771,000 | 43,113,000 | 30,017,000 | 10,971,000 | 7,179,000 | 9,005,000 | 3,318,000 | 3,460,000 | 1,374,000 | 6,808,000 | 1,293,000 | 1,216,000 | 970,000 | 1,011,000 | 20,890,000 | 30,027,000 | 11,247,000 | 60,000,000 | 15,000,000 | 3,000,000 | 5,000,000 | 5,000,000 | 3,000,000 | 7,000,000 | ||||||||||
operating expenses: | ||||||||||||||||||||||||||||||||||||||
research and development | 33,991,000 | 25,559,000 | 31,407,000 | 37,824,000 | 41,180,000 | 42,589,000 | 42,212,000 | 41,997,000 | 37,042,000 | 33,525,000 | 30,878,000 | 32,923,000 | 34,957,000 | 23,374,000 | 22,064,000 | 20,844,000 | 22,516,000 | 26,776,000 | 22,221,000 | 25,314,000 | 24,185,000 | 21,567,000 | 19,542,000 | 17,948,000 | 20,968,000 | 21,426,000 | 29,931,000 | 27,350,000 | 20,631,000 | 15,920,000 | 17,883,000 | 10,583,000 | 11,810,000 | 7,606,000 | 6,697,000 | 7,205,000 | 7,935,000 | |
general and administrative | 26,202,000 | 15,789,000 | 10,209,000 | 10,609,000 | 14,130,000 | 10,194,000 | 10,562,000 | 9,295,000 | 12,338,000 | 10,276,000 | 10,172,000 | 10,680,000 | 10,818,000 | 9,407,000 | 8,862,000 | 8,171,000 | 10,203,000 | 5,392,000 | 5,432,000 | 5,246,000 | 5,423,000 | 5,088,000 | 4,794,000 | 4,687,000 | 4,285,000 | 3,832,000 | 3,814,000 | 4,307,000 | 4,141,000 | 3,743,000 | 4,004,000 | 3,832,000 | 3,947,000 | 2,545,000 | 2,390,000 | 2,350,000 | 2,053,000 | |
total operating expenses | 60,193,000 | 41,348,000 | 41,616,000 | 48,433,000 | 55,310,000 | 52,783,000 | 52,774,000 | 51,292,000 | 49,380,000 | 51,140,000 | 41,050,000 | 43,603,000 | 45,775,000 | 32,781,000 | 30,926,000 | 29,015,000 | 32,719,000 | 32,168,000 | 27,653,000 | 30,560,000 | 29,608,000 | 26,655,000 | 24,336,000 | 22,635,000 | 25,253,000 | 25,258,000 | 33,745,000 | 31,657,000 | 24,772,000 | 19,663,000 | 21,887,000 | 14,415,000 | 15,757,000 | 10,151,000 | 9,087,000 | 9,555,000 | 9,988,000 | |
income from operations | -34,637,000 | 66,901,000 | 34,704,000 | -26,170,000 | -27,539,000 | -9,670,000 | -22,757,000 | -40,321,000 | -42,201,000 | -42,135,000 | -37,732,000 | -40,143,000 | -44,401,000 | -25,973,000 | -29,633,000 | -27,799,000 | -31,749,000 | -31,157,000 | -6,763,000 | -533,000 | -18,361,000 | 33,345,000 | -24,336,000 | -22,635,000 | -10,253,000 | -22,258,000 | -33,745,000 | -26,657,000 | -24,772,000 | -19,663,000 | -16,887,000 | -14,415,000 | -15,757,000 | -7,151,000 | -9,087,000 | -2,555,000 | -9,988,000 | |
yoy | 25.77% | -791.84% | -252.50% | -35.10% | -34.74% | -77.05% | -39.69% | 0.44% | -4.95% | 62.23% | 27.33% | 44.40% | 39.85% | -16.64% | 338.16% | 5115.57% | 72.92% | -193.44% | -72.21% | -97.65% | 79.08% | -249.81% | -27.88% | -15.09% | -58.61% | 13.20% | 99.83% | 84.93% | 57.21% | 174.97% | 85.84% | 464.19% | 57.76% | |||||
qoq | -151.77% | 92.78% | -232.61% | -4.97% | 184.79% | -57.51% | -43.56% | -4.45% | 0.16% | 11.67% | -6.01% | -9.59% | 70.95% | -12.35% | 6.60% | -12.44% | 1.90% | 360.70% | 1168.86% | -97.10% | -155.06% | -237.02% | 7.51% | 120.76% | -53.94% | -34.04% | 26.59% | 7.61% | 25.98% | 16.44% | 17.15% | -8.52% | 120.35% | -21.31% | 255.66% | -74.42% | ||
other income, net: | ||||||||||||||||||||||||||||||||||||||
interest income | 2,653,000 | 2,508,000 | 2,924,000 | 3,654,000 | 4,413,000 | 5,263,000 | 5,324,000 | 4,623,000 | 4,584,000 | 4,880,000 | 4,854,000 | 4,653,000 | 4,486,000 | 3,839,000 | 2,262,000 | 1,107,000 | 342,000 | 68,000 | 64,000 | 104,000 | 195,000 | 376,000 | 625,000 | 1,061,000 | 1,897,000 | 2,282,000 | 2,757,000 | 2,957,000 | 2,988,000 | 2,834,000 | 1,369,000 | 1,297,000 | 1,185,000 | |||||
non-cash interest expense for the sale of future royalties | -20,859,000 | -19,711,000 | -22,515,000 | -19,606,000 | -18,061,000 | -17,404,000 | -15,413,000 | -10,953,000 | -6,317,000 | -4,958,000 | -4,431,000 | -4,358,000 | -4,336,000 | -4,251,000 | -6,135,000 | -5,868,000 | -4,854,000 | |||||||||||||||||||||
other income | -1,000 | -3,000 | 3,531,000 | 1,902,000 | 21,000 | -5,000 | 1,000 | 3,000 | -4,000 | -4,000 | 4,000 | 6,000 | 6,000 | 1,000 | 33,000 | 3,000 | -75,000 | -56,000 | 26,000 | 94,000 | -109,000 | 144,000 | -41,000 | 7,000 | 8,000 | -40,000 | -64,000 | -63,000 | -877,000 | 449,000 | 310,000 | 347,000 | ||||||
total other expense | -18,207,000 | -10,939,500 | -19,591,000 | -12,421,000 | -11,746,000 | |||||||||||||||||||||||||||||||||
income before income taxes | -52,844,000 | 49,695,000 | 15,113,000 | -38,591,000 | -39,285,000 | -21,790,000 | -32,851,000 | -46,651,000 | 33,646,000 | -23,767,000 | -21,548,000 | -8,262,000 | -20,285,000 | -31,084,000 | -24,022,000 | -22,097,000 | ||||||||||||||||||||||
provision for income taxes | -40,000 | -20,750 | -39,000 | -44,000 | -2,250 | -9,000 | 22,000 | 51,000 | 60,000 | 19,000 | ||||||||||||||||||||||||||||
net income | -52,884,000 | 49,614,000 | 15,113,000 | -38,630,000 | -39,329,000 | -21,784,000 | -32,851,000 | -46,660,000 | -43,936,000 | -42,211,000 | -37,308,000 | -39,845,000 | -44,255,000 | -26,413,000 | -33,502,000 | -32,554,000 | -36,255,000 | -32,538,000 | -6,666,000 | -429,000 | -18,163,000 | 33,646,000 | -23,767,000 | -21,548,000 | -8,262,000 | -20,263,000 | -31,033,000 | -23,962,000 | -22,078,000 | -16,994,000 | -15,958,000 | -13,618,000 | -15,086,000 | -6,861,000 | -9,090,000 | -2,684,000 | -11,435,000 | |
yoy | 34.47% | -327.75% | -146.00% | -17.21% | -10.49% | -48.39% | -11.95% | 17.10% | -0.72% | 59.81% | 11.36% | 22.40% | 22.07% | -18.82% | 402.58% | 7488.34% | 99.61% | -196.71% | -71.95% | -98.01% | 119.84% | -266.05% | -23.41% | -10.07% | -62.58% | 19.24% | 94.47% | 75.96% | 46.35% | 147.69% | 75.56% | 407.38% | 31.93% | |||||
qoq | -206.59% | 228.29% | -139.12% | -1.78% | 80.54% | -33.69% | -29.59% | 6.20% | 4.09% | 13.14% | -6.37% | -9.96% | 67.55% | -21.16% | 2.91% | -10.21% | 11.42% | 388.12% | 1453.85% | -97.64% | -153.98% | -241.57% | 10.30% | 160.81% | -59.23% | -34.70% | 29.51% | 8.53% | 29.92% | 6.49% | 17.18% | -9.73% | 119.88% | -24.52% | 238.67% | -76.53% | ||
other comprehensive loss: | ||||||||||||||||||||||||||||||||||||||
unrealized loss on available-for-sale securities | -122,000 | |||||||||||||||||||||||||||||||||||||
comprehensive loss | -53,006,000 | -38,797,000 | -39,473,000 | -22,238,000 | -31,677,000 | -46,451,000 | -43,763,000 | -40,658,000 | -36,047,000 | -40,189,000 | -42,276,000 | -25,652,000 | -35,648,000 | -33,981,000 | -38,267,000 | -32,760,000 | -6,690,000 | -494,000 | -18,270,000 | 33,383,000 | -24,261,000 | -21,940,000 | -7,455,000 | -20,405,000 | -31,127,000 | -23,592,000 | -21,651,000 | -16,676,000 | -15,822,000 | -13,494,000 | -15,887,000 | -7,244,000 | -9,074,000 | -11,448,000 | ||||
net loss per common share: | ||||||||||||||||||||||||||||||||||||||
basic and diluted | -1,840 | -1,340 | -1,280 | -660 | -1,140 | -1,710 | -1,640 | -1,590 | -1,410 | -1,500 | -1,580 | -930 | -1,180 | -1,150 | -1,310 | -1,190 | -240 | -20 | -660 | 1,230 | -870 | -790 | -300 | -750 | -1,150 | -890 | -820 | -640 | -660 | -570 | -630 | -750 | ||||||
weighted-average number of shares outstanding: | ||||||||||||||||||||||||||||||||||||||
basic and diluted | 28,691,000 | 28,758,000 | 28,810,000 | 30,644,000 | 28,382,000 | 28,893,000 | 27,356,000 | 26,801,000 | 26,924,000 | 26,546,000 | 26,629,000 | 27,953,000 | 28,165,000 | 28,289,000 | 28,204,000 | 27,713,000 | 27,431,000 | 27,436,000 | 27,391,000 | 27,361,000 | 27,302,000 | 27,316,000 | 27,279,000 | 27,264,000 | 27,059,000 | 27,058,000 | 27,026,000 | 26,981,000 | 24,673,000 | 24,146,000 | 23,932,000 | 23,801,000 | 19,782,000 | 15,295,000 | ||||
unrealized gain on available for sale securities | -71,000 | 53,000 | -167,000 | -144,000 | -454,000 | 1,174,000 | 209,000 | 173,000 | 1,553,000 | 1,261,000 | -344,000 | 1,979,000 | ||||||||||||||||||||||||||
comprehensive income | -15,776,000 | 15,166,000 | -2,730,000 | |||||||||||||||||||||||||||||||||||
net income per common share: | ||||||||||||||||||||||||||||||||||||||
basic | -540 | 540 | -130 | |||||||||||||||||||||||||||||||||||
diluted | -540 | 520 | -130 | |||||||||||||||||||||||||||||||||||
weighted-average number of shares outstanding: | ||||||||||||||||||||||||||||||||||||||
basic | 27,833,000 | 20,382,000 | 20,271,000 | |||||||||||||||||||||||||||||||||||
diluted | 29,018,000 | 20,382,000 | 20,271,000 | |||||||||||||||||||||||||||||||||||
total other income | -12,120,000 | -10,094,000 | -6,330,000 | -1,735,000 | -80,000 | 424,000 | 298,000 | 146,000 | -416,000 | -3,869,000 | -4,755,000 | -4,506,000 | -1,381,000 | 97,000 | 104,000 | 198,000 | 301,000 | 569,000 | 1,087,000 | 1,991,000 | 1,973,000 | 2,661,000 | 2,635,000 | 2,675,000 | 2,477,000 | 929,000 | 797,000 | 671,000 | 290,000 | -3,000 | -129,000 | -1,447,000 | ||||||
other expense | -2,000 | |||||||||||||||||||||||||||||||||||||
unrealized loss on available for sale securities | 761,000 | -2,146,000 | -1,427,000 | -2,012,000 | -49,000 | -24,000 | -801,000 | -46,000 | -13,000 | |||||||||||||||||||||||||||||
unrealized income on available for sale securities | -65,000 | -107,000 | 373,000 | 136,000 | 124,000 | -10,750 | 16,000 | |||||||||||||||||||||||||||||||
interest expense | -200,000 | -240,000 | -281,000 | -320,000 | -365,000 | -400,000 | -436,000 | -451,000 | -456,000 | -452,000 | -439,000 | -428,000 | ||||||||||||||||||||||||||
other comprehensive income: | ||||||||||||||||||||||||||||||||||||||
unrealized income on available for sale securities, net of tax of 0, (25), 0 and 189, respectively | -19,750 | -494,000 | ||||||||||||||||||||||||||||||||||||
unrealized income on available for sale securities, net of tax of 0, 99, 0 and 214, respectively | -392,000 | |||||||||||||||||||||||||||||||||||||
unrealized income on available for sale securities, net of tax of 0 and 115, respectively | 807,000 | |||||||||||||||||||||||||||||||||||||
unrealized income on available for sale securities, net of tax of (25), 0, 189 and 0, respectively | 175,750 | -94,000 | ||||||||||||||||||||||||||||||||||||
unrealized income on available for sale securities, net of tax of 99, 0, 214 and 0, respectively | 370,000 | |||||||||||||||||||||||||||||||||||||
unrealized income on available for sale securities, net of tax of 115 and 0, respectively | 427,000 | |||||||||||||||||||||||||||||||||||||
change in fair value of liability for preferred stock warrants | -1,366,000 | |||||||||||||||||||||||||||||||||||||
other comprehensive income | -28,750 | 136,000 | 124,000 | -10,750 | 16,000 | |||||||||||||||||||||||||||||||||
other comprehensive loss | -801,000 | -46,000 | -13,000 | |||||||||||||||||||||||||||||||||||
net income attributed to participating securities | ||||||||||||||||||||||||||||||||||||||
net loss attributed to common stockholders | -5,802,250 | -9,090,000 | ||||||||||||||||||||||||||||||||||||
net loss per common share: | ||||||||||||||||||||||||||||||||||||||
basic | -310 | -450 | ||||||||||||||||||||||||||||||||||||
diluted | -310 | -450 | ||||||||||||||||||||||||||||||||||||
net income attributed to common stockholders | -2,684,000 |
Balance Sheets:
Quarterly
Annual
| Unit: USD | 2026-03-31 | 2025-12-31 | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2017-12-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | 2016-12-31 |
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assets | ||||||||||||||||||||||||||||||||||||||
current assets: | ||||||||||||||||||||||||||||||||||||||
cash and cash equivalents | 248,469,000 | 238,196,000 | 109,833,000 | 44,298,000 | 98,637,000 | 123,080,000 | 191,581,000 | 71,821,000 | 53,695,000 | 35,965,000 | 26,295,000 | 35,206,000 | 94,562,000 | 71,308,000 | 58,547,000 | 71,701,000 | 166,412,000 | 495,729,000 | 336,328,000 | 332,254,000 | 284,148,000 | 250,456,000 | 209,154,000 | 221,172,000 | 165,317,000 | 171,017,000 | 182,898,000 | 146,552,000 | 105,853,000 | 113,596,000 | 293,408,000 | 57,057,000 | 69,474,000 | 81,189,000 | 26,669,000 | 30,752,000 | 96,754,000 | 51,232,000 |
receivables from collaborative partners | 25,747,000 | 33,850,000 | 75,685,000 | 21,418,000 | 17,884,000 | 40,765,000 | 12,195,000 | 9,007,000 | 7,089,000 | 6,851,000 | 3,269,000 | 3,182,000 | 1,523,000 | 1,419,000 | 1,180,000 | 1,033,000 | 921,000 | 876,000 | 761,000 | |||||||||||||||||||
short-term investments | 37,986,000 | 73,442,000 | 139,123,000 | 221,412,000 | 241,299,000 | 262,293,000 | 238,536,000 | 278,983,000 | 300,970,000 | 354,939,000 | 386,752,000 | 394,280,000 | 336,589,000 | 369,933,000 | 384,419,000 | 370,450,000 | 339,209,000 | 52,368,000 | 37,736,000 | 58,597,000 | 96,212,000 | 143,197,000 | 129,192,000 | 156,706,000 | 197,166,000 | 203,210,000 | 238,104,000 | 275,664,000 | 309,812,000 | 313,486,000 | 200,406,000 | 210,852,000 | 178,691,000 | 167,218,000 | 89,053,000 | 75,607,000 | 6,742,000 | |
prepaid expenses and other current assets | 3,907,000 | 4,762,000 | 6,009,000 | 4,778,000 | 5,292,000 | 5,738,000 | 6,369,000 | 7,539,000 | 10,666,000 | 9,080,000 | 11,684,000 | 5,867,000 | 4,480,000 | 4,545,000 | 6,298,000 | 9,625,000 | 5,869,000 | 4,903,000 | 11,759,000 | 6,508,000 | 5,464,000 | 2,908,000 | 7,468,000 | 6,638,000 | 3,572,000 | 3,506,000 | 3,595,000 | 3,772,000 | 6,102,000 | 6,960,000 | 4,035,000 | 3,758,000 | 2,170,000 | 2,688,000 | 3,119,000 | 3,852,000 | 1,694,000 | 1,633,000 |
total current assets | 316,109,000 | 350,250,000 | 330,650,000 | 291,906,000 | 363,112,000 | 431,876,000 | 448,681,000 | 367,350,000 | 372,420,000 | 406,835,000 | 428,000,000 | 438,535,000 | 437,154,000 | 447,205,000 | 450,444,000 | 452,809,000 | 512,411,000 | 553,876,000 | 386,644,000 | 398,061,000 | 387,131,000 | 396,561,000 | 345,814,000 | 384,516,000 | 371,055,000 | 377,733,000 | 424,597,000 | 430,988,000 | 421,942,000 | 434,216,000 | 503,022,000 | 271,819,000 | 251,945,000 | 252,696,000 | 120,327,000 | 115,848,000 | 110,155,000 | 58,208,000 |
property and equipment | 1,280,000 | 1,370,000 | 1,500,000 | 1,628,000 | 1,741,000 | 1,849,000 | 1,728,000 | 1,833,000 | 1,954,000 | 2,098,000 | 2,254,000 | 2,023,000 | 1,982,000 | 2,089,000 | 1,972,000 | 2,059,000 | 2,162,000 | 2,283,000 | 2,413,000 | 2,488,000 | 1,754,000 | 1,783,000 | 1,585,000 | 1,495,000 | 1,610,000 | 1,618,000 | 1,695,000 | 1,481,000 | 1,584,000 | 1,445,000 | 1,344,000 | 1,086,000 | 659,000 | 665,000 | 513,000 | 543,000 | 569,000 | 471,000 |
operating lease right-of-use assets | 12,039,000 | 12,519,000 | 12,994,000 | 13,464,000 | 13,923,000 | 14,383,000 | 14,839,000 | 15,291,000 | 15,732,000 | 16,174,000 | 16,613,000 | 17,047,000 | 17,471,000 | 17,898,000 | 18,320,000 | 18,739,000 | 19,147,000 | 19,558,000 | 19,778,000 | 20,278,000 | ||||||||||||||||||
other long-term assets | 256,000 | 256,000 | 256,000 | 256,000 | 256,000 | 256,000 | 256,000 | 256,000 | 256,000 | 256,000 | 256,000 | 256,000 | 256,000 | 256,000 | 256,000 | 256,000 | 256,000 | 256,000 | 258,000 | 258,000 | 477,000 | 602,000 | 1,114,000 | 1,354,000 | 1,293,000 | 1,481,000 | 1,735,000 | 1,913,000 | 2,089,000 | 148,000 | 79,000 | 322,000 | 289,000 | |||||
total assets | 329,684,000 | 364,395,000 | 353,098,000 | 335,250,000 | 422,053,000 | 483,834,000 | 493,418,000 | 427,376,000 | 405,835,000 | 452,389,000 | 487,326,000 | 517,100,000 | 551,792,000 | 610,383,000 | 618,503,000 | 603,848,000 | 625,171,000 | 643,070,000 | 424,335,000 | 426,569,000 | 396,418,000 | 416,552,000 | 384,750,000 | 401,746,000 | 424,233,000 | 435,197,000 | 451,505,000 | 480,149,000 | 494,226,000 | 508,997,000 | 523,121,000 | 306,017,000 | 314,837,000 | 329,364,000 | 121,945,000 | 130,409,000 | 131,111,000 | 62,180,000 |
liabilities and stockholders’ equity | ||||||||||||||||||||||||||||||||||||||
current liabilities: | ||||||||||||||||||||||||||||||||||||||
accounts payable | 7,517,000 | 3,871,000 | 2,893,000 | 3,329,000 | 6,123,000 | 4,002,000 | 3,592,000 | 4,890,000 | 4,582,000 | 4,698,000 | 6,521,000 | 4,761,000 | 3,168,000 | 2,784,000 | 3,006,000 | 1,587,000 | 2,481,000 | 1,741,000 | 5,717,000 | 4,103,000 | 2,452,000 | 4,217,000 | 5,484,000 | 6,289,000 | 8,571,000 | 16,237,000 | 10,522,000 | 10,921,000 | 9,072,000 | 5,443,000 | 6,180,000 | 4,426,000 | 2,416,000 | 2,323,000 | 2,557,000 | 3,724,000 | 2,546,000 | 2,278,000 |
accrued expenses | 32,065,000 | 32,674,000 | 33,171,000 | 30,197,000 | 35,952,000 | 39,501,000 | 38,401,000 | 33,680,000 | 25,903,000 | 30,967,000 | 30,916,000 | 35,164,000 | 30,956,000 | 21,633,000 | 16,453,000 | 16,714,000 | 15,763,000 | 12,853,000 | 14,075,000 | 15,958,000 | 11,826,000 | 15,262,000 | 18,139,000 | 12,916,000 | 13,781,000 | 11,052,000 | 15,286,000 | 14,102,000 | 8,400,000 | 8,761,000 | 7,145,000 | 4,837,000 | 4,405,000 | 4,875,000 | 3,604,000 | 3,230,000 | 4,330,000 | 3,429,000 |
current portion of operating lease liability | 2,120,000 | 2,080,000 | 2,040,000 | 2,001,000 | 1,962,000 | 1,925,000 | 1,887,000 | 1,850,000 | 1,813,000 | 1,777,000 | 1,741,000 | 1,706,000 | 1,671,000 | 1,637,000 | 1,604,000 | 1,570,000 | 1,537,000 | 1,505,000 | 1,097,000 | 555,000 | ||||||||||||||||||
total current liabilities | 41,702,000 | 38,625,000 | 38,104,000 | 35,527,000 | 44,037,000 | 45,428,000 | 43,880,000 | 40,420,000 | 32,298,000 | 37,442,000 | 39,178,000 | 41,631,000 | 35,795,000 | 26,054,000 | 21,063,000 | 19,871,000 | 19,781,000 | 16,099,000 | 20,889,000 | 20,616,000 | 14,475,000 | 19,821,000 | 24,474,000 | 20,130,000 | 23,250,000 | 29,535,000 | 29,730,000 | 30,623,000 | 24,754,000 | 21,836,000 | 20,873,000 | 16,790,000 | 14,343,000 | 14,090,000 | 11,174,000 | 10,079,000 | 8,126,000 | 5,708,000 |
liability related to sale of future royalties | 263,742,000 | 276,528,000 | 331,844,000 | 331,361,000 | 330,382,000 | 353,426,000 | 350,564,000 | 361,981,000 | 310,184,000 | 310,807,000 | 311,272,000 | 310,073,000 | 307,516,000 | 304,413,000 | 301,586,000 | 261,019,000 | 255,584,000 | 251,093,000 | ||||||||||||||||||||
operating lease liability, net of current portion | 11,493,000 | 12,032,000 | 12,566,000 | 13,095,000 | 13,613,000 | 14,112,000 | 14,607,000 | 15,096,000 | 15,575,000 | 16,037,000 | 16,493,000 | 16,946,000 | 17,388,000 | 17,813,000 | 18,235,000 | 18,652,000 | 19,059,000 | 19,450,000 | 19,838,000 | 20,222,000 | ||||||||||||||||||
stockholders’ equity: | ||||||||||||||||||||||||||||||||||||||
preferred stock, 0.001 par value... | ||||||||||||||||||||||||||||||||||||||
common stock, 0.001 par value... | 29,000 | 28,000 | 28,000 | 28,000 | 30,000 | 30,000 | 30,000 | 27,000 | 27,000 | 27,000 | 27,000 | 27,000 | 27,000 | 29,000 | 28,000 | 28,000 | 28,000 | 28,000 | 27,000 | 27,000 | 27,000 | 27,000 | 27,000 | 27,000 | 27,000 | 27,000 | 27,000 | 27,000 | 27,000 | 27,000 | 27,000 | 24,000 | 24,000 | 24,000 | 20,000 | 20,000 | 20,000 | 3,000 |
additional paid-in capital | 838,307,000 | 657,560,000 | ||||||||||||||||||||||||||||||||||||
accumulated other comprehensive loss | -146,000 | -415,000 | -624,000 | -797,000 | -2,350,000 | -3,611,000 | -3,267,000 | -5,246,000 | -6,007,000 | -3,861,000 | -2,434,000 | -422,000 | -200,000 | -176,000 | -111,000 | -223,000 | -541,000 | -677,000 | -801,000 | -426,000 | -43,000 | -59,000 | ||||||||||||||||
accumulated deficit | -825,443,000 | -772,559,000 | -822,173,000 | -837,286,000 | -798,656,000 | -759,327,000 | -737,543,000 | -704,692,000 | -658,032,000 | -614,096,000 | -571,885,000 | -534,577,000 | -494,732,000 | -450,477,000 | -424,064,000 | -390,562,000 | -358,008,000 | -321,753,000 | -289,215,000 | -282,549,000 | -282,120,000 | -263,957,000 | -297,603,000 | -273,836,000 | -252,288,000 | -244,026,000 | -223,763,000 | -192,730,000 | -168,768,000 | -146,690,000 | -129,696,000 | -113,738,000 | -100,120,000 | -85,034,000 | -78,173,000 | -69,083,000 | -66,399,000 | -54,923,000 |
total stockholders’ equity | 12,747,000 | 37,210,000 | 34,021,000 | 70,868,000 | 84,367,000 | 9,879,000 | 47,778,000 | 88,103,000 | 120,383,000 | 148,450,000 | 191,093,000 | 262,103,000 | 277,619,000 | 304,306,000 | 330,747,000 | 356,428,000 | 383,608,000 | 385,731,000 | 381,943,000 | 396,731,000 | 360,243,000 | 381,436,000 | 400,564,000 | 405,008,000 | 420,892,000 | 448,421,000 | 468,155,000 | 486,365,000 | 499,677,000 | 284,979,000 | 294,527,000 | 307,581,000 | 101,355,000 | 109,175,000 | 110,115,000 | |||
total liabilities and stockholders’ equity | 329,684,000 | 364,395,000 | 335,250,000 | 422,053,000 | 483,834,000 | 493,418,000 | 427,376,000 | 405,835,000 | 452,389,000 | 487,326,000 | 517,100,000 | 551,792,000 | 610,383,000 | 618,503,000 | 603,848,000 | 625,171,000 | 643,070,000 | 424,335,000 | 426,569,000 | 396,418,000 | 416,552,000 | 384,750,000 | 401,746,000 | 424,233,000 | 451,505,000 | 480,149,000 | 494,226,000 | |||||||||||
long-term investments | 7,698,000 | 27,996,000 | 43,021,000 | 35,470,000 | 27,914,000 | 42,646,000 | 15,473,000 | 27,026,000 | 40,203,000 | 59,239,000 | 94,929,000 | 142,935,000 | 147,511,000 | 129,985,000 | 91,195,000 | 67,097,000 | 15,242,000 | 5,484,000 | 7,056,000 | 17,546,000 | 36,177,000 | 14,321,000 | 50,215,000 | 54,305,000 | 23,418,000 | 45,707,000 | 68,551,000 | 73,128,000 | 18,616,000 | 32,730,000 | 61,884,000 | 75,897,000 | 999,000 | 13,912,000 | 20,327,000 | |||
additional paid in capital | 809,765,000 | 792,682,000 | 792,531,000 | 832,486,000 | 829,860,000 | 821,121,000 | 714,959,000 | 706,407,000 | 702,969,000 | 694,591,000 | 686,611,000 | 689,065,000 | 717,797,000 | 707,662,000 | 698,701,000 | 691,161,000 | 678,575,000 | 672,996,000 | 668,429,000 | 664,147,000 | 660,665,000 | 654,492,000 | 651,680,000 | 648,669,000 | 644,148,000 | 640,550,000 | 636,692,000 | 633,251,000 | 629,887,000 | 399,370,000 | 395,424,000 | 393,017,000 | 179,551,000 | 178,297,000 | 176,507,000 | 16,672,000 | ||
accumulated other comprehensive gain | -24,000 | 47,000 | -6,000 | 161,000 | 305,000 | 759,000 | ||||||||||||||||||||||||||||||||
stockholders’ (deficit) equity: | ||||||||||||||||||||||||||||||||||||||
total stockholders’ (deficit) equity | -29,416,000 | -44,733,000 | ||||||||||||||||||||||||||||||||||||
total liabilities and stockholders’ (deficit) equity | 353,098,000 | |||||||||||||||||||||||||||||||||||||
long-term restricted cash | ||||||||||||||||||||||||||||||||||||||
short-term restricted cash | 60,000 | |||||||||||||||||||||||||||||||||||||
receivable from collaborative partners | 642,000 | 1,247,000 | 5,000,000 | 5,000,000 | 5,000,000 | 1,225,000 | ||||||||||||||||||||||||||||||||
restricted cash | 60,000 | 60,000 | 60,000 | 60,000 | 60,000 | 60,000 | 60,000 | 60,000 | 60,000 | 60,000 | 60,000 | 60,000 | 60,000 | 60,000 | 60,000 | 60,000 | 60,000 | 60,000 | 60,000 | |||||||||||||||||||
other current liabilities | 197,000 | 342,000 | 851,000 | 925,000 | 898,000 | 871,000 | 845,000 | 819,000 | 794,000 | 58,000 | 48,000 | 27,000 | 22,000 | 17,000 | 13,000 | 1,000 | ||||||||||||||||||||||
notes payable, current portion | 1,375,000 | 3,077,000 | 4,781,000 | 6,488,000 | 7,574,000 | 7,500,000 | 7,500,000 | 7,500,000 | 6,875,000 | 5,000,000 | 3,125,000 | 1,250,000 | ||||||||||||||||||||||||||
other long-term liabilities | 33,000 | 180,000 | 419,000 | 654,000 | 883,000 | 1,105,000 | 1,317,000 | |||||||||||||||||||||||||||||||
accumulated other comprehensive income | -4,000 | 259,000 | 753,000 | 1,145,000 | 338,000 | 480,000 | 574,000 | 204,000 | -13,000 | |||||||||||||||||||||||||||||
australian tax incentive receivable | 175,000 | 174,000 | 173,000 | 152,000 | 1,610,000 | 1,601,000 | 1,486,000 | 5,637,000 | 4,965,000 | 4,118,000 | ||||||||||||||||||||||||||||
total liabilities, preferred stock and stockholders’ equity | 435,197,000 | 508,997,000 | 523,121,000 | 306,017,000 | 314,837,000 | |||||||||||||||||||||||||||||||||
liabilities, preferred stock andstockholders’ equity | ||||||||||||||||||||||||||||||||||||||
notes payable, net of current portion | 625,000 | 2,409,000 | 4,120,000 | 5,834,000 | 7,553,000 | 9,269,000 | 10,987,000 | 12,709,000 | 13,809,000 | |||||||||||||||||||||||||||||
deferred rent | 171,000 | 162,000 | 128,000 | 133,000 | 140,000 | 147,000 | 168,000 | 161,000 | 154,000 | |||||||||||||||||||||||||||||
liabilities, preferred stock and stockholders’ equity | ||||||||||||||||||||||||||||||||||||||
long-term vendor deposits | 46,000 | 46,000 | 46,000 | |||||||||||||||||||||||||||||||||||
deferred financing costs | 3,441,000 | |||||||||||||||||||||||||||||||||||||
liabilities, convertible preferred stock andstockholders’ equity | ||||||||||||||||||||||||||||||||||||||
preferred stock warrant liabilities | 3,241,000 | |||||||||||||||||||||||||||||||||||||
commitments and contingencies | ||||||||||||||||||||||||||||||||||||||
series b convertible preferred stock, 0.001 par value... | 28,220,000 | |||||||||||||||||||||||||||||||||||||
series c convertible preferred stock, 0.001 par value... | 6,452,000 | |||||||||||||||||||||||||||||||||||||
series c-1 convertible preferred stock, 0.001 par value... | 2,156,000 | |||||||||||||||||||||||||||||||||||||
series d convertible preferred stock, 0.001 par value... | 40,688,000 | |||||||||||||||||||||||||||||||||||||
stockholders’ equity | ||||||||||||||||||||||||||||||||||||||
total liabilities, convertible preferred stock and stockholders’ equity | 329,364,000 | 121,945,000 | 130,409,000 | 131,111,000 | ||||||||||||||||||||||||||||||||||
liabilities, convertible preferred stock and stockholders’ deficit | ||||||||||||||||||||||||||||||||||||||
deferred revenue | ||||||||||||||||||||||||||||||||||||||
income taxes payable | ||||||||||||||||||||||||||||||||||||||
stockholders’ deficit: | ||||||||||||||||||||||||||||||||||||||
total stockholders’ deficit | -38,248,000 | |||||||||||||||||||||||||||||||||||||
total liabilities, convertible preferred stock and stockholders’ deficit | 62,180,000 |
Cashflow Statements:
Quarterly
Annual
| Unit: USD | 2026-03-31 | 2025-12-31 | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2017-12-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cash flows from operating activities: | |||||||||||||||||||||||||||||||||||||
net loss | -52,884,000 | 49,614,000 | 15,113,000 | -38,630,000 | -39,329,000 | -21,784,000 | -32,851,000 | -46,660,000 | -43,936,000 | -42,211,000 | -37,308,000 | -39,845,000 | -44,255,000 | -32,554,000 | -36,255,000 | -32,538,000 | -6,666,000 | -429,000 | -18,163,000 | 33,646,000 | -23,767,000 | -21,548,000 | -8,262,000 | -20,263,000 | -31,033,000 | -23,962,000 | -22,078,000 | -16,994,000 | -15,958,000 | -13,618,000 | -15,086,000 | -11,435,000 | |||||
adjustments to reconcile net loss to net cash from operating activities: | |||||||||||||||||||||||||||||||||||||
depreciation and amortization | 130,000 | 131,000 | 140,000 | 142,000 | 146,000 | 145,000 | 144,000 | 154,000 | 163,000 | 165,000 | 158,000 | 163,000 | 166,000 | 184,000 | 166,000 | 163,000 | 162,000 | 165,000 | 169,000 | 160,000 | 125,000 | 144,000 | 138,000 | 137,000 | 140,000 | 140,000 | 135,000 | 124,000 | 115,000 | 106,000 | 91,000 | 64,000 | 54,000 | 47,000 | 46,000 | 51,000 | 39,000 |
stock-based compensation | 14,218,000 | 8,506,000 | 9,157,000 | 9,239,000 | 9,170,000 | 8,184,000 | 8,189,000 | 7,544,000 | 10,131,000 | 8,111,000 | 7,807,000 | 8,427,000 | 8,860,000 | 6,685,000 | 6,271,000 | 6,658,000 | 7,742,000 | 3,978,000 | 4,364,000 | 3,690,000 | 3,315,000 | 2,978,000 | 2,805,000 | 2,741,000 | 2,975,000 | 2,757,000 | 3,144,000 | 3,643,000 | 2,867,000 | 2,621,000 | 2,532,000 | 2,548,000 | 2,260,000 | 1,132,000 | 942,000 | 1,438,000 | 866,000 |
accretion/amortization of investments | -8,000 | -340,000 | -1,130,000 | -1,597,000 | -1,667,000 | -2,302,000 | -2,566,000 | -2,477,000 | -2,968,000 | -3,154,000 | -2,993,000 | -2,183,000 | -2,191,000 | -1,723,000 | 161,000 | 100,000 | 100,000 | 126,000 | 167,000 | 222,000 | 178,000 | 69,000 | -8,000 | -184,000 | -523,000 | ||||||||||||
amortization of right-of-use assets – operating | 480,000 | 475,000 | 470,000 | 459,000 | 460,000 | 456,000 | 452,000 | 441,000 | 442,000 | 439,000 | 434,000 | 424,000 | 427,000 | 422,000 | 419,000 | 408,000 | 411,000 | 220,000 | 500,000 | ||||||||||||||||||
non-cash interest expense for sale of future royalties | 20,859,000 | ||||||||||||||||||||||||||||||||||||
changes in operating assets and liabilities: | |||||||||||||||||||||||||||||||||||||
receivables from collaborative partners | 8,103,000 | 41,835,000 | -54,267,000 | -3,534,000 | 22,881,000 | -28,570,000 | -3,188,000 | -1,918,000 | -238,000 | -3,582,000 | -87,000 | -1,659,000 | -104,000 | -239,000 | -147,000 | -112,000 | -45,000 | -115,000 | |||||||||||||||||||
prepaid expenses and other assets | 1,501,000 | 971,000 | -303,000 | 414,000 | 530,000 | 299,000 | 1,405,000 | 3,065,000 | -1,566,000 | 2,843,000 | -5,796,000 | -1,292,000 | 51,000 | 1,705,000 | 2,821,000 | -4,118,000 | -1,221,000 | 6,740,000 | -5,306,000 | -959,000 | -2,276,000 | 5,008,000 | -424,000 | -2,711,000 | 233,000 | 253,000 | 490,000 | 2,649,000 | -1,214,000 | -3,785,000 | -217,000 | -1,574,000 | 388,000 | -304,000 | 909,000 | -2,347,000 | -143,000 |
accounts payable and other liabilities | -17,819,000 | -22,412,000 | -18,561,000 | -22,320,000 | -24,034,000 | -40,047,000 | 3,364,000 | 8,018,000 | -5,172,000 | -1,498,000 | -2,702,000 | 6,605,000 | 8,533,000 | 4,832,000 | 1,257,000 | 75,000 | 3,536,000 | -5,321,000 | -191,000 | 5,897,000 | -5,125,000 | -4,446,000 | 4,057,000 | -3,298,000 | -5,190,000 | 1,319,000 | 520,000 | 7,584,000 | 5,076,000 | 1,137,000 | 3,849,000 | 2,255,000 | -158,000 | 1,137,000 | -1,019,000 | 1,418,000 | 682,000 |
deferred income | 3,544,000 | ||||||||||||||||||||||||||||||||||||
operating lease liabilities | -499,000 | -494,000 | -490,000 | -479,000 | -462,000 | -457,000 | -452,000 | -442,000 | -426,000 | -420,000 | -418,000 | -407,000 | -391,000 | -389,000 | -383,000 | -374,000 | -359,000 | 20,000 | 158,000 | ||||||||||||||||||
net cash from operating activities | -25,919,000 | 97,997,000 | -27,356,000 | -40,244,000 | -10,700,000 | -66,672,000 | -10,090,000 | -21,322,000 | -37,253,000 | -34,349,000 | -36,474,000 | -25,409,000 | -24,568,000 | -10,685,000 | -17,747,000 | -24,147,000 | -21,014,000 | -25,301,000 | -7,006,000 | 9,591,000 | -23,204,000 | 37,578,000 | -17,013,000 | -19,610,000 | -15,112,000 | -15,805,000 | -22,096,000 | -15,517,000 | -16,099,000 | -12,290,000 | -14,860,000 | -8,878,000 | -12,478,000 | -4,810,000 | -3,888,000 | -2,643,000 | -8,097,000 |
capital expenditures | -17,000 | -1,000 | -12,000 | -39,000 | -35,000 | -263,000 | -35,000 | -33,000 | -27,000 | -280,000 | -162,000 | -190,000 | -175,000 | -175,000 | -50,000 | -78,000 | -55,000 | -14,000 | -172,000 | -863,000 | -317,000 | -311,000 | -88,000 | -83,000 | -87,000 | -104,000 | -280,000 | -241,000 | -180,000 | -206,000 | -321,000 | -304,000 | -232,000 | -124,000 | -13,000 | -68,000 | -85,000 |
free cash flows | -25,936,000 | 97,996,000 | -27,368,000 | -40,283,000 | -10,735,000 | -66,935,000 | -10,125,000 | -21,355,000 | -37,280,000 | -34,629,000 | -36,636,000 | -25,599,000 | -24,743,000 | -10,860,000 | -17,797,000 | -24,225,000 | -21,069,000 | -25,315,000 | -7,178,000 | 8,728,000 | -23,521,000 | 37,267,000 | -17,101,000 | -19,693,000 | -15,199,000 | -15,909,000 | -22,376,000 | -15,758,000 | -16,279,000 | -12,496,000 | -15,181,000 | -9,182,000 | -12,710,000 | -4,934,000 | -3,901,000 | -2,711,000 | -8,182,000 |
cash flows from investing activities: | |||||||||||||||||||||||||||||||||||||
purchase of investments | |||||||||||||||||||||||||||||||||||||
sales and maturities of investments | 35,000,000 | 73,501,000 | 122,950,000 | 90,650,000 | 137,429,000 | 91,749,000 | 110,000,000 | 146,743,000 | 127,640,000 | 115,765,000 | 100,845,000 | 98,744,000 | 134,126,000 | 149,250,000 | 147,746,000 | 101,400,000 | 9,620,000 | 25,500,000 | 27,744,000 | 42,320,000 | 63,284,000 | 42,264,000 | 74,445,000 | 88,411,000 | 84,851,000 | 80,905,000 | 102,879,000 | 110,667,000 | 89,600,000 | 57,598,000 | 58,520,000 | 55,450,000 | 34,581,000 | 27,271,000 | |||
purchases of property and equipment | -17,000 | -1,000 | -12,000 | -39,000 | -35,000 | -263,000 | -35,000 | -33,000 | -27,000 | -280,000 | -162,000 | -190,000 | -175,000 | -175,000 | -50,000 | -78,000 | -55,000 | -14,000 | -172,000 | -863,000 | -317,000 | -311,000 | -88,000 | -83,000 | -87,000 | -104,000 | -280,000 | -241,000 | -180,000 | -206,000 | -321,000 | -304,000 | -232,000 | -124,000 | -13,000 | -68,000 | -85,000 |
net cash from investing activities | 34,983,000 | 73,500,000 | 103,282,000 | 36,403,000 | 14,847,000 | -29,396,000 | 58,620,000 | -2,442,000 | 68,616,000 | 49,178,000 | 30,635,000 | -20,455,000 | 85,396,000 | 21,497,000 | -32,434,000 | -70,996,000 | -312,912,000 | -66,694,000 | 10,839,000 | 37,961,000 | 56,729,000 | 3,598,000 | 4,732,000 | 75,394,000 | 10,751,000 | 4,035,000 | -166,150,000 | 24,615,000 | -3,062,000 | 2,146,000 | -153,057,000 | -495,000 | -62,421,000 | -27,085,000 | |||
cash flows from financing activities: | |||||||||||||||||||||||||||||||||||||
proceeds from issuance of common stock | 14,021,000 | 12,212,000 | 336,000 | 1,423,000 | 290,000 | 555,000 | 4,128,000 | 979,000 | 811,000 | 264,000 | 160,000 | 783,000 | 1,265,000 | 3,419,000 | 2,699,000 | 865,000 | 4,844,000 | ||||||||||||||||||||
repurchase and retirements of common stock | -9,720,000 | -51,098,000 | -4,424,000 | 0 | -12,474,000 | -37,526,000 | |||||||||||||||||||||||||||||||
payment for net share settlement of equity awards | 0 | 0 | 0 | -1,451,000 | 0 | 0 | 0 | -7,504,000 | |||||||||||||||||||||||||||||
principal repayment of liability for sale of future royalties | -12,812,000 | -51,962,000 | -1,007,000 | -823,000 | -23,005,000 | ||||||||||||||||||||||||||||||||
net cash from financing activities | 1,209,000 | -43,134,000 | -10,391,000 | -50,498,000 | -28,590,000 | 27,567,000 | 71,230,000 | 41,890,000 | -13,633,000 | -5,159,000 | -3,072,000 | -13,492,000 | -37,574,000 | 37,027,000 | 432,000 | 4,609,000 | 241,000 | 554,000 | 167,000 | 126,000 | 263,000 | 71,000 | -1,339,000 | -111,000 | -1,421,000 | -1,660,000 | -1,301,000 | -1,372,000 | 226,596,000 | -477,000 | -1,383,000 | 212,387,000 | 300,000 | -938,000 | 80,704,000 | ||
net increase in cash and cash equivalents | 10,273,000 | 128,363,000 | 65,535,000 | -54,339,000 | -24,443,000 | -68,501,000 | 119,760,000 | 18,126,000 | 17,730,000 | 23,254,000 | -13,154,000 | -94,711,000 | -329,317,000 | ||||||||||||||||||||||||
cash and cash equivalents, beginning of period | 238,196,000 | 0 | 0 | 0 | 123,080,000 | 0 | 0 | 0 | 35,965,000 | ||||||||||||||||||||||||||||
cash and cash equivalents, end of period | 248,469,000 | 128,363,000 | 65,535,000 | -54,339,000 | 98,637,000 | -68,501,000 | 119,760,000 | 18,126,000 | 53,695,000 | ||||||||||||||||||||||||||||
supplemental disclosure of cash flow information | |||||||||||||||||||||||||||||||||||||
interest portion of repayment for sale of future royalties | 20,833,000 | 23,065,000 | 21,025,000 | 17,804,000 | 18,100,000 | ||||||||||||||||||||||||||||||||
state income taxes paid | 40,000 | ||||||||||||||||||||||||||||||||||||
non-cash investing and financing activities: | |||||||||||||||||||||||||||||||||||||
amounts accrued for property and equipment | 23,000 | 11,000 | 3,000 | -271,000 | 227,000 | 14,000 | 38,000 | 126,000 | 19,000 | 20,000 | -78,000 | 31,000 | 58,000 | 114,000 | 140,000 | -61,000 | 86,000 | -41,000 | 68,000 | -219,000 | 233,000 | -1,000 | -34,000 | 187,000 | 7,000 | 179,000 | 3,000 | -43,000 | 52,000 | ||||||||
amounts accrued for repurchase of common stock | |||||||||||||||||||||||||||||||||||||
receivable related to issuance of common stock, upon exercise of stock options | 304,000 | -423,000 | 0 | 0 | -8,000 | -43,000 | 32,000 | -9,000 | |||||||||||||||||||||||||||||
proceeds from public offerings, net of underwriters' fees | 0 | ||||||||||||||||||||||||||||||||||||
proceeds from the sale of future royalties | 0 | 0 | 0 | ||||||||||||||||||||||||||||||||||
payments for repurchase of common stock | |||||||||||||||||||||||||||||||||||||
payments for offering costs | -122,000 | 0 | -280,000 | -102,000 | -12,000 | -1,086,000 | -399,000 | ||||||||||||||||||||||||||||||
payments for issuance costs related to the sale of future royalties | |||||||||||||||||||||||||||||||||||||
non-cash interest expense | 22,515,000 | 19,606,000 | 18,061,000 | 15,413,000 | 10,953,000 | 6,317,000 | 4,958,000 | 4,431,000 | 4,358,000 | 4,336,000 | 4,251,000 | 6,135,000 | 5,868,000 | 4,854,000 | 173,000 | 171,000 | 168,000 | 164,000 | 165,000 | 164,000 | 161,000 | 156,000 | 159,000 | 157,000 | |||||||||||||
purchases of investments | -19,656,000 | -54,208,000 | -122,547,000 | -51,345,000 | -149,152,000 | -58,997,000 | -70,048,000 | -119,009,000 | -48,555,000 | -180,130,000 | -172,318,000 | -322,477,000 | -16,748,000 | ||||||||||||||||||||||||
proceeds from public offerings, net of underwriters’ fees | |||||||||||||||||||||||||||||||||||||
payments for debt issuance costs | -67,000 | 0 | 0 | -43,000 | -288,000 | 0 | -2,000 | ||||||||||||||||||||||||||||||
income taxes paid | 0 | 39,000 | 5,000 | ||||||||||||||||||||||||||||||||||
amounts accrued for repurchases of common stock | 74,000 | -479,000 | 959,000 | -13,000 | -818,000 | 1,290,000 | |||||||||||||||||||||||||||||||
amounts accrued for offering costs | -178,000 | 1,290,000 | |||||||||||||||||||||||||||||||||||
amounts accrued for issuance costs related to the sale of future royalties | 56,000 | -104,000 | 0 | 128,000 | |||||||||||||||||||||||||||||||||
repayment of liability for sale of future royalties | -26,830,000 | -9,053,000 | -6,940,000 | -5,423,000 | -3,232,000 | -1,801,000 | -1,270,000 | -1,424,000 | -384,000 | -433,000 | -233,000 | ||||||||||||||||||||||||||
gain on disposal of property and equipment | |||||||||||||||||||||||||||||||||||||
proceeds from the sale of property and equipment | 0 | ||||||||||||||||||||||||||||||||||||
net increase in cash, cash equivalents, and restricted cash | 159,341,000 | 4,074,000 | 48,106,000 | 33,692,000 | 41,302,000 | -12,018,000 | -11,881,000 | 36,346,000 | -179,812,000 | -11,715,000 | 45,522,000 | ||||||||||||||||||||||||||
cash, cash equivalents and restricted cash, beginning of period | 0 | 0 | 0 | 71,308,000 | 0 | 0 | 0 | 495,729,000 | 0 | 0 | 0 | 250,516,000 | 0 | 0 | 0 | 171,077,000 | 0 | 0 | 0 | 113,656,000 | 0 | 0 | 0 | 81,249,000 | 0 | 0 | 0 | 51,292,000 | |||||||||
cash, cash equivalents and restricted cash, end of period | 9,670,000 | -8,911,000 | -59,356,000 | 94,562,000 | 12,761,000 | -13,154,000 | -94,711,000 | 166,412,000 | 159,341,000 | 4,074,000 | 48,106,000 | 284,208,000 | 41,302,000 | -12,018,000 | 55,855,000 | 165,377,000 | -11,881,000 | 36,346,000 | 40,699,000 | 105,913,000 | -179,812,000 | 236,351,000 | -12,417,000 | 69,534,000 | 54,520,000 | -4,083,000 | -66,002,000 | 96,814,000 | |||||||||
leased assets obtained in exchange for operating lease liabilities | 0 | 0 | |||||||||||||||||||||||||||||||||||
net decrease in cash and cash equivalents | -8,911,000 | ||||||||||||||||||||||||||||||||||||
loss on disposal of property and equipment, net of gain on lease termination | |||||||||||||||||||||||||||||||||||||
payments on notes payable | 0 | 0 | 0 | -1,375,000 | -1,875,000 | -1,875,000 | -1,875,000 | -1,875,000 | -1,875,000 | -1,875,000 | -1,875,000 | -1,250,000 | |||||||||||||||||||||||||
net cash provided (used in) by financing activities | |||||||||||||||||||||||||||||||||||||
interest paid | 0 | 0 | 0 | 4,000 | 40,000 | 83,000 | 129,000 | 172,000 | 208,000 | 250,000 | 288,000 | 297,000 | 327,000 | 293,000 | 191,000 | 278,000 | |||||||||||||||||||||
net income | -9,090,000 | ||||||||||||||||||||||||||||||||||||
adjustments to reconcile net income to net cash from operating activities: | |||||||||||||||||||||||||||||||||||||
australian tax incentive receivable | 0 | 0 | 175,000 | -1,000 | -1,000 | -21,000 | 1,458,000 | -9,000 | -115,000 | 4,151,000 | -672,000 | -847,000 | |||||||||||||||||||||||||
proceeds from issuance of common stock, upon the exercise of stock options | 241,000 | 554,000 | 167,000 | 126,000 | 263,000 | 71,000 | 36,000 | 1,764,000 | 454,000 | 215,000 | 574,000 | 731,000 | 669,000 | 1,397,000 | 72,000 | 165,000 | 311,000 | 148,000 | 355,000 | ||||||||||||||||||
receivable from collaborative partners | 605,000 | -1,247,000 | -5,000,000 | 0 | 0 | 0 | 1,225,000 | ||||||||||||||||||||||||||||||
acquisition of investments | -6,238,000 | -38,355,000 | -69,625,000 | -12,934,000 | -74,013,000 | -76,766,000 | -42,736,000 | -52,550,000 | -79,763,000 | -223,542,000 | -33,584,000 | -58,208,000 | -32,203,000 | -180,204,000 | -21,348,000 | -62,353,000 | -27,000,000 | ||||||||||||||||||||
income taxes | |||||||||||||||||||||||||||||||||||||
proceeds from issuance of common stock, upon the exercise of warrants | 0 | 0 | 1,000 | 75,000 | 0 | 1,000 | 0 | 535,000 | |||||||||||||||||||||||||||||
net decrease in cash, cash equivalents, and restricted cash | -5,700,000 | -7,743,000 | -4,083,000 | ||||||||||||||||||||||||||||||||||
change in fair value of liability for preferred stock warrants | 0 | 0 | 0 | 1,366,000 | |||||||||||||||||||||||||||||||||
reclassification of warrants to equity | 0 | 0 | 0 | 4,607,000 | |||||||||||||||||||||||||||||||||
proceeds for offering costs | |||||||||||||||||||||||||||||||||||||
net from investing activities | |||||||||||||||||||||||||||||||||||||
accretion of discount on investments | -1,028,000 | ||||||||||||||||||||||||||||||||||||
net provided by investing activities | 9,657,000 | ||||||||||||||||||||||||||||||||||||
loss from investments | -678,000 | -83,000 | |||||||||||||||||||||||||||||||||||
loss on disposal of property and equipment | |||||||||||||||||||||||||||||||||||||
deferred revenue | |||||||||||||||||||||||||||||||||||||
proceeds from debt | |||||||||||||||||||||||||||||||||||||
fair value of warrants issued with debt | |||||||||||||||||||||||||||||||||||||
income from investments | -5,000 | ||||||||||||||||||||||||||||||||||||
income taxes payable | |||||||||||||||||||||||||||||||||||||
proceeds from the issuance of preferred stock, net of issuance cost | |||||||||||||||||||||||||||||||||||||
noncash investing and financing activities: | |||||||||||||||||||||||||||||||||||||
proceeds from initial public offering, net of underwriters fees | 0 | 0 | 80,213,000 | ||||||||||||||||||||||||||||||||||
noncash interest expense | 150,000 | ||||||||||||||||||||||||||||||||||||
restricted cash | |||||||||||||||||||||||||||||||||||||
proceeds from sale of property and equipment | |||||||||||||||||||||||||||||||||||||
proceeds from the issuance of preferred stock, net of issuance costs | |||||||||||||||||||||||||||||||||||||
payments for deferred offering costs | |||||||||||||||||||||||||||||||||||||
amounts accrued for deferred financing costs | |||||||||||||||||||||||||||||||||||||
conversion of convertible promissory notes payable to related parties into shares of series c-1 preferred stock |
