Quarterly
Annual
| Unit: USD | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2017-12-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cash flows from operating activities: | |||||||||||||||||||||||||||||||||||
net income | 15,113,000 | -38,630,000 | -39,329,000 | -21,784,000 | -32,851,000 | -46,660,000 | -43,936,000 | -42,211,000 | -37,308,000 | -39,845,000 | -44,255,000 | -26,413,000 | -33,502,000 | -32,554,000 | -36,255,000 | -32,538,000 | -6,666,000 | -429,000 | -18,163,000 | 33,646,000 | -23,767,000 | -21,548,000 | -8,262,000 | -20,263,000 | -31,033,000 | -23,962,000 | -22,078,000 | -16,994,000 | -15,958,000 | -13,618,000 | -15,086,000 | -6,861,000 | -9,090,000 | -2,684,000 | -11,435,000 |
adjustments to reconcile net income to net cash from operating activities: | |||||||||||||||||||||||||||||||||||
depreciation and amortization | 140,000 | 142,000 | 146,000 | 145,000 | 144,000 | 154,000 | 163,000 | 165,000 | 158,000 | 163,000 | 166,000 | 184,000 | 166,000 | 163,000 | 162,000 | 165,000 | 169,000 | 160,000 | 125,000 | 144,000 | 138,000 | 137,000 | 140,000 | 140,000 | 135,000 | 124,000 | 115,000 | 106,000 | 91,000 | 64,000 | 54,000 | 47,000 | 46,000 | 51,000 | 39,000 |
stock-based compensation | 9,157,000 | 9,239,000 | 9,170,000 | 8,184,000 | 8,189,000 | 7,544,000 | 10,131,000 | 8,111,000 | 7,807,000 | 8,427,000 | 8,860,000 | 6,685,000 | 6,271,000 | 6,658,000 | 7,742,000 | 3,978,000 | 4,364,000 | 3,690,000 | 3,315,000 | 2,978,000 | 2,805,000 | 2,741,000 | 2,975,000 | 2,757,000 | 3,144,000 | 3,643,000 | 2,867,000 | 2,621,000 | 2,532,000 | 2,548,000 | 2,260,000 | 1,132,000 | 942,000 | 1,438,000 | 866,000 |
accretion/amortization of investments | -1,130,000 | -1,597,000 | -1,667,000 | -2,302,000 | -2,566,000 | -2,477,000 | -2,968,000 | -3,154,000 | -2,993,000 | -2,183,000 | -2,191,000 | -1,723,000 | 161,000 | 100,000 | 100,000 | 126,000 | 167,000 | 222,000 | 178,000 | 69,000 | -8,000 | -184,000 | -523,000 | ||||||||||||
amortization of right-of-use assets – operating | 470,000 | 459,000 | 460,000 | 456,000 | 452,000 | 441,000 | 442,000 | 439,000 | 434,000 | 424,000 | 427,000 | 422,000 | 419,000 | 408,000 | 411,000 | 220,000 | 500,000 | ||||||||||||||||||
non-cash interest expense | 22,515,000 | 19,606,000 | 18,061,000 | 15,413,000 | 10,953,000 | 6,317,000 | 4,958,000 | 4,431,000 | 4,358,000 | 4,336,000 | 4,251,000 | 6,135,000 | 5,868,000 | 4,854,000 | 173,000 | 171,000 | 168,000 | 164,000 | 165,000 | 164,000 | 161,000 | 156,000 | 159,000 | 157,000 | |||||||||||
changes in operating assets and liabilities: | |||||||||||||||||||||||||||||||||||
receivables from collaborative partners | -54,267,000 | -3,534,000 | 22,881,000 | -28,570,000 | -3,188,000 | -1,918,000 | -238,000 | -3,582,000 | -87,000 | -1,659,000 | -104,000 | -239,000 | -147,000 | -112,000 | -45,000 | -115,000 | |||||||||||||||||||
prepaid expenses and other assets | -303,000 | 414,000 | 530,000 | 299,000 | 1,405,000 | 3,065,000 | -1,566,000 | 2,843,000 | -5,796,000 | -1,292,000 | 51,000 | 1,705,000 | 2,821,000 | -4,118,000 | -1,221,000 | 6,740,000 | -5,306,000 | -959,000 | -2,276,000 | 5,008,000 | -424,000 | -2,711,000 | 233,000 | 253,000 | 490,000 | 2,649,000 | -1,214,000 | -3,785,000 | -217,000 | -1,574,000 | 388,000 | -304,000 | 909,000 | -2,347,000 | -143,000 |
accounts payable and other liabilities | -18,561,000 | -22,320,000 | -24,034,000 | -40,047,000 | 3,364,000 | 8,018,000 | -5,172,000 | -1,498,000 | -2,702,000 | 6,605,000 | 8,533,000 | 4,832,000 | 1,257,000 | 75,000 | 3,536,000 | -5,321,000 | -191,000 | 5,897,000 | -5,125,000 | -4,446,000 | 4,057,000 | -3,298,000 | -5,190,000 | 1,319,000 | 520,000 | 7,584,000 | 5,076,000 | 1,137,000 | 3,849,000 | 2,255,000 | -158,000 | 1,137,000 | -1,019,000 | 1,418,000 | 682,000 |
operating lease liabilities | -490,000 | -479,000 | -462,000 | -457,000 | -452,000 | -442,000 | -426,000 | -420,000 | -418,000 | -407,000 | -391,000 | -389,000 | -383,000 | -374,000 | -359,000 | 20,000 | 158,000 | ||||||||||||||||||
net cash from operating activities | -27,356,000 | -40,244,000 | -10,700,000 | -66,672,000 | -10,090,000 | -21,322,000 | -37,253,000 | -34,349,000 | -36,474,000 | -25,409,000 | -24,568,000 | -10,685,000 | -17,747,000 | -24,147,000 | -21,014,000 | -25,301,000 | -7,006,000 | 9,591,000 | -23,204,000 | 37,578,000 | -17,013,000 | -19,610,000 | -15,112,000 | -15,805,000 | -22,096,000 | -15,517,000 | -16,099,000 | -12,290,000 | -14,860,000 | -8,878,000 | -12,478,000 | -4,810,000 | -3,888,000 | -2,643,000 | -8,097,000 |
capex | -12,000 | -39,000 | -35,000 | -263,000 | -35,000 | -33,000 | -27,000 | -280,000 | -162,000 | -190,000 | -175,000 | -175,000 | -50,000 | -78,000 | -55,000 | -14,000 | -172,000 | -863,000 | -317,000 | -311,000 | -88,000 | -83,000 | -87,000 | -104,000 | -280,000 | -241,000 | -180,000 | -206,000 | -321,000 | -304,000 | -232,000 | -124,000 | -13,000 | -68,000 | -85,000 |
free cash flows | -27,368,000 | -40,283,000 | -10,735,000 | -66,935,000 | -10,125,000 | -21,355,000 | -37,280,000 | -34,629,000 | -36,636,000 | -25,599,000 | -24,743,000 | -10,860,000 | -17,797,000 | -24,225,000 | -21,069,000 | -25,315,000 | -7,178,000 | 8,728,000 | -23,521,000 | 37,267,000 | -17,101,000 | -19,693,000 | -15,199,000 | -15,909,000 | -22,376,000 | -15,758,000 | -16,279,000 | -12,496,000 | -15,181,000 | -9,182,000 | -12,710,000 | -4,934,000 | -3,901,000 | -2,711,000 | -8,182,000 |
cash flows from investing activities: | |||||||||||||||||||||||||||||||||||
purchases of investments | -19,656,000 | -54,208,000 | -122,547,000 | -51,345,000 | -149,152,000 | -58,997,000 | -70,048,000 | -119,009,000 | -48,555,000 | -180,130,000 | -172,318,000 | -322,477,000 | -16,748,000 | ||||||||||||||||||||||
sales and maturities of investments | 122,950,000 | 90,650,000 | 137,429,000 | 91,749,000 | 110,000,000 | 146,743,000 | 127,640,000 | 115,765,000 | 100,845,000 | 98,744,000 | 134,126,000 | 149,250,000 | 147,746,000 | 101,400,000 | 9,620,000 | 25,500,000 | 27,744,000 | 42,320,000 | 63,284,000 | 42,264,000 | 74,445,000 | 88,411,000 | 84,851,000 | 80,905,000 | 102,879,000 | 110,667,000 | 89,600,000 | 57,598,000 | 58,520,000 | 55,450,000 | 34,581,000 | 27,271,000 | |||
purchases of property and equipment | -12,000 | -39,000 | -35,000 | -263,000 | -35,000 | -33,000 | -27,000 | -280,000 | -162,000 | -190,000 | -175,000 | -175,000 | -50,000 | -78,000 | -55,000 | -14,000 | -172,000 | -863,000 | -317,000 | -311,000 | -88,000 | -83,000 | -87,000 | -104,000 | -280,000 | -241,000 | -180,000 | -206,000 | -321,000 | -304,000 | -232,000 | -124,000 | -13,000 | -68,000 | -85,000 |
net cash from investing activities | 103,282,000 | 36,403,000 | 14,847,000 | -29,396,000 | 58,620,000 | -2,442,000 | 68,616,000 | 49,178,000 | 30,635,000 | -20,455,000 | 85,396,000 | 21,497,000 | -32,434,000 | -70,996,000 | -312,912,000 | -66,694,000 | 10,839,000 | 37,961,000 | 56,729,000 | 3,598,000 | 4,732,000 | 75,394,000 | 10,751,000 | 4,035,000 | -166,150,000 | 24,615,000 | -3,062,000 | 2,146,000 | -153,057,000 | -495,000 | -62,421,000 | -27,085,000 | |||
cash flows from financing activities: | |||||||||||||||||||||||||||||||||||
proceeds from public offerings, net of underwriters’ fees | |||||||||||||||||||||||||||||||||||
proceeds from issuance of common stock | 336,000 | 1,423,000 | 290,000 | 555,000 | 4,128,000 | 979,000 | 811,000 | 264,000 | 160,000 | 783,000 | 1,265,000 | 3,419,000 | 2,699,000 | 865,000 | 4,844,000 | ||||||||||||||||||||
repurchase and retirements of common stock | -9,720,000 | -51,098,000 | -4,424,000 | 0 | -12,474,000 | -37,526,000 | |||||||||||||||||||||||||||||
proceeds from the sale of future royalties | 0 | 0 | 0 | ||||||||||||||||||||||||||||||||
payment for net share settlement of equity awards | 0 | 0 | -1,451,000 | 0 | 0 | 0 | -7,504,000 | ||||||||||||||||||||||||||||
principal repayment of liability for sale of future royalties | -1,007,000 | -823,000 | -23,005,000 | ||||||||||||||||||||||||||||||||
payments for offering costs | -122,000 | 0 | -280,000 | -102,000 | -12,000 | -1,086,000 | -399,000 | ||||||||||||||||||||||||||||
payments for debt issuance costs | -67,000 | 0 | 0 | -43,000 | -288,000 | 0 | -2,000 | ||||||||||||||||||||||||||||
net cash from financing activities | -10,391,000 | -50,498,000 | -28,590,000 | 27,567,000 | 71,230,000 | 41,890,000 | -13,633,000 | -5,159,000 | -3,072,000 | -13,492,000 | -37,574,000 | 37,027,000 | 432,000 | 4,609,000 | 241,000 | 554,000 | 167,000 | 126,000 | 263,000 | 71,000 | -1,339,000 | -111,000 | -1,421,000 | -1,660,000 | -1,301,000 | -1,372,000 | 226,596,000 | -477,000 | -1,383,000 | 212,387,000 | 300,000 | -938,000 | 80,704,000 | ||
net increase in cash and cash equivalents | 65,535,000 | -54,339,000 | -24,443,000 | -68,501,000 | 119,760,000 | 18,126,000 | 17,730,000 | 23,254,000 | -13,154,000 | -94,711,000 | -329,317,000 | ||||||||||||||||||||||||
cash and cash equivalents, beginning of period | 0 | 0 | 123,080,000 | 0 | 0 | 0 | 35,965,000 | ||||||||||||||||||||||||||||
cash and cash equivalents, end of period | 65,535,000 | -54,339,000 | 98,637,000 | -68,501,000 | 119,760,000 | 18,126,000 | 53,695,000 | ||||||||||||||||||||||||||||
supplemental disclosure of cash flow information | |||||||||||||||||||||||||||||||||||
interest portion of repayment for sale of future royalties | 21,025,000 | 17,804,000 | 18,100,000 | ||||||||||||||||||||||||||||||||
income taxes paid | 0 | 39,000 | 5,000 | ||||||||||||||||||||||||||||||||
non-cash investing and financing activities: | |||||||||||||||||||||||||||||||||||
amounts accrued for property and equipment | 11,000 | 3,000 | -271,000 | 227,000 | 14,000 | 38,000 | 126,000 | 19,000 | 20,000 | -78,000 | 31,000 | 58,000 | 114,000 | 140,000 | -61,000 | 86,000 | -41,000 | 68,000 | -219,000 | 233,000 | -1,000 | -34,000 | 187,000 | 7,000 | 179,000 | 3,000 | -43,000 | 52,000 | |||||||
amounts accrued for repurchases of common stock | 74,000 | -479,000 | 959,000 | -13,000 | -818,000 | 1,290,000 | |||||||||||||||||||||||||||||
receivable related to issuance of common stock, upon exercise of stock options | 0 | 0 | -8,000 | -43,000 | 32,000 | -9,000 | |||||||||||||||||||||||||||||
amounts accrued for offering costs | -178,000 | 1,290,000 | |||||||||||||||||||||||||||||||||
amounts accrued for issuance costs related to the sale of future royalties | 56,000 | -104,000 | 0 | 128,000 | |||||||||||||||||||||||||||||||
deferred income | 3,544,000 | ||||||||||||||||||||||||||||||||||
non-cash interest expense for sale of future royalties | |||||||||||||||||||||||||||||||||||
purchase of investments | |||||||||||||||||||||||||||||||||||
proceeds from public offerings, net of underwriters' fees | 0 | ||||||||||||||||||||||||||||||||||
payments for repurchase of common stock | |||||||||||||||||||||||||||||||||||
payments for issuance costs related to the sale of future royalties | |||||||||||||||||||||||||||||||||||
amounts accrued for repurchase of common stock | |||||||||||||||||||||||||||||||||||
repayment of liability for sale of future royalties | -26,830,000 | -9,053,000 | -6,940,000 | -5,423,000 | -3,232,000 | -1,801,000 | -1,270,000 | -1,424,000 | -384,000 | -433,000 | -233,000 | ||||||||||||||||||||||||
gain on disposal of property and equipment | |||||||||||||||||||||||||||||||||||
proceeds from the sale of property and equipment | 0 | ||||||||||||||||||||||||||||||||||
net increase in cash, cash equivalents, and restricted cash | 159,341,000 | 4,074,000 | 48,106,000 | 33,692,000 | 41,302,000 | -12,018,000 | -11,881,000 | 36,346,000 | -179,812,000 | -11,715,000 | 45,522,000 | ||||||||||||||||||||||||
cash, cash equivalents and restricted cash, beginning of period | 0 | 0 | 0 | 71,308,000 | 0 | 0 | 0 | 495,729,000 | 0 | 0 | 0 | 250,516,000 | 0 | 0 | 0 | 171,077,000 | 0 | 0 | 0 | 113,656,000 | 0 | 0 | 0 | 81,249,000 | 0 | 0 | 0 | 51,292,000 | |||||||
cash, cash equivalents and restricted cash, end of period | 9,670,000 | -8,911,000 | -59,356,000 | 94,562,000 | 12,761,000 | -13,154,000 | -94,711,000 | 166,412,000 | 159,341,000 | 4,074,000 | 48,106,000 | 284,208,000 | 41,302,000 | -12,018,000 | 55,855,000 | 165,377,000 | -11,881,000 | 36,346,000 | 40,699,000 | 105,913,000 | -179,812,000 | 236,351,000 | -12,417,000 | 69,534,000 | 54,520,000 | -4,083,000 | -66,002,000 | 96,814,000 | |||||||
leased assets obtained in exchange for operating lease liabilities | 0 | 0 | |||||||||||||||||||||||||||||||||
net decrease in cash and cash equivalents | -8,911,000 | ||||||||||||||||||||||||||||||||||
(gain) loss on disposal of property and equipment, net of gain on lease termination | |||||||||||||||||||||||||||||||||||
payments on notes payable | 0 | 0 | 0 | -1,375,000 | -1,875,000 | -1,875,000 | -1,875,000 | -1,875,000 | -1,875,000 | -1,875,000 | -1,875,000 | -1,250,000 | |||||||||||||||||||||||
net cash provided (used in) by financing activities | |||||||||||||||||||||||||||||||||||
interest paid | 0 | 0 | 0 | 4,000 | 40,000 | 83,000 | 129,000 | 172,000 | 208,000 | 250,000 | 288,000 | 297,000 | 327,000 | 293,000 | 191,000 | 278,000 | |||||||||||||||||||
australian tax incentive receivable | 0 | 0 | 175,000 | -1,000 | -1,000 | -21,000 | 1,458,000 | -9,000 | -115,000 | 4,151,000 | -672,000 | -847,000 | |||||||||||||||||||||||
proceeds from issuance of common stock, upon the exercise of stock options | 241,000 | 554,000 | 167,000 | 126,000 | 263,000 | 71,000 | 36,000 | 1,764,000 | 454,000 | 215,000 | 574,000 | 731,000 | 669,000 | 1,397,000 | 72,000 | 165,000 | 311,000 | 148,000 | 355,000 | ||||||||||||||||
receivable from collaborative partners | 605,000 | -1,247,000 | -5,000,000 | 0 | 0 | 0 | 1,225,000 | ||||||||||||||||||||||||||||
acquisition of investments | -6,238,000 | -38,355,000 | -69,625,000 | -12,934,000 | -74,013,000 | -76,766,000 | -42,736,000 | -52,550,000 | -79,763,000 | -223,542,000 | -33,584,000 | -58,208,000 | -32,203,000 | -180,204,000 | -21,348,000 | -62,353,000 | -27,000,000 | ||||||||||||||||||
income taxes | |||||||||||||||||||||||||||||||||||
loss on disposal of property and equipment, net of gain on lease termination | |||||||||||||||||||||||||||||||||||
proceeds from issuance of common stock, upon the exercise of warrants | 0 | 0 | 1,000 | 75,000 | 0 | 1,000 | 0 | 535,000 | |||||||||||||||||||||||||||
net decrease in cash, cash equivalents, and restricted cash | -5,700,000 | -7,743,000 | -4,083,000 | ||||||||||||||||||||||||||||||||
change in fair value of liability for preferred stock warrants | 0 | 0 | 0 | 1,366,000 | |||||||||||||||||||||||||||||||
reclassification of warrants to equity | 0 | 0 | 0 | 4,607,000 | |||||||||||||||||||||||||||||||
proceeds for offering costs | |||||||||||||||||||||||||||||||||||
net provided by investing activities | 57,876,000 | 9,657,000 | |||||||||||||||||||||||||||||||||
accretion of discount on investments | -1,028,000 | ||||||||||||||||||||||||||||||||||
(income) income from investments | -678,000 | -83,000 | |||||||||||||||||||||||||||||||||
loss on disposal of property and equipment | |||||||||||||||||||||||||||||||||||
deferred revenue | |||||||||||||||||||||||||||||||||||
proceeds from debt | |||||||||||||||||||||||||||||||||||
fair value of warrants issued with debt | |||||||||||||||||||||||||||||||||||
proceeds (payments) for offering costs | |||||||||||||||||||||||||||||||||||
income from investments | -5,000 | ||||||||||||||||||||||||||||||||||
income taxes payable | |||||||||||||||||||||||||||||||||||
proceeds from the issuance of preferred stock, net of issuance cost | |||||||||||||||||||||||||||||||||||
noncash investing and financing activities: | |||||||||||||||||||||||||||||||||||
proceeds from initial public offering, net of underwriters fees | 0 | 0 | 80,213,000 | ||||||||||||||||||||||||||||||||
noncash interest expense | 150,000 | ||||||||||||||||||||||||||||||||||
restricted cash | |||||||||||||||||||||||||||||||||||
proceeds from sale of property and equipment | |||||||||||||||||||||||||||||||||||
proceeds from the issuance of preferred stock, net of issuance costs | |||||||||||||||||||||||||||||||||||
payments for deferred offering costs | |||||||||||||||||||||||||||||||||||
amounts accrued for deferred financing costs | |||||||||||||||||||||||||||||||||||
conversion of convertible promissory notes payable to related parties into shares of series c-1 preferred stock |
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