7Baggers

Amarin Corporation plc
(NASDAQ:AMRN) 

AMRN stock logo

Amarin Corporation plc, a pharmaceutical company, engages in the development and commercialization of therapeutics for the treatment of cardiovascular diseases in the United States. Its lead product is VASCEPA, a prescription-only omega-3 fatty acid product, used as an adjunct to diet for reducing t...

Founded: 1989
Full Time Employees: 965
Sector: Healthcare
Industry: Biotechnology

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Quarterly
Annual
    Unit: USD2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-11-10 2009-12-31 2009-07-01 2008-09-25 2008-05-19 2007-11-20 2007-08-01 2007-05-10 2007-02-08 2007-01-25 2006-11-09 2006-09-06 2006-08-03 2006-05-11 2006-02-09 2005-09-30 2004-12-31 2004-09-30 2003-12-31 2002-12-31 2001-12-31 
                                                                                      
      product revenue
    46,543,000 48,558,000 46,617,000 41,035,000 60,068,000 41,852,000 47,514,000 55,156,000 70,555,000 64,903,000 65,187,000 84,654,000 89,507,000 89,222,000 93,796,000 93,986,000 143,722,000 141,442,000 153,773,000 141,383,000 165,907,000 155,190,000 133,724,000 152,204,000 142,044,000 112,250,000 100,366,000 72,731,000 77,085,000 54,973,000 52,537,000 43,777,000 53,482,000 47,051,000 44,948,000 34,344,000 38,403,000 32,441,000 32,815,000 25,307,000 26,402,000 21,320,000 17,707,000 15,558,000                                       
      licensing and royalty revenue
    2,676,000 1,112,000 26,124,000 982,000 2,238,000 446,000 19,977,000 1,363,000 4,158,000 1,153,000 14,980,000 1,321,000 738,000 656,000 644,000 644,000 769,000 596,000 715,000 787,000 1,344,000 1,309,000 1,593,000 2,789,000                                                           
      total revenue
    49,219,000 49,670,000 72,741,000 42,017,000 62,306,000 42,298,000 67,491,000 56,519,000 74,713,000 66,056,000 80,167,000 85,975,000 90,245,000 89,878,000 94,440,000 94,630,000 144,491,000 142,038,000 154,488,000 142,170,000 167,251,000 156,499,000 135,317,000 154,993,000 143,277,000 112,408,000 100,792,000 73,278,000 77,330,000 55,323,000 52,643,000 43,919,000 53,866,000 47,360,000 45,241,000 34,637,000 38,696,000 32,734,000 33,111,000 25,543,000 26,633,000 21,483,000 17,707,000 15,933,000                                       
      yoy
    -21.00% 17.43% 7.78% -25.66% -16.61% -35.97% -15.81% -34.26% -17.21% -26.50% -15.11% -9.15% -37.54% -36.72% -38.87% -33.44% -13.61% -9.24% 14.17% -8.27% 16.73% 39.22% 34.25% 111.51% 85.28% 103.18% 91.46% 66.85% 43.56% 16.81% 16.36% 26.80% 39.20% 44.68% 36.63% 35.60% 45.29% 52.37% 86.99% 60.32%                                           
      qoq
    -0.91% -31.72% 73.12% -32.56% 47.30% -37.33% 19.41% -24.35% 13.11% -17.60% -6.76% -4.73% 0.41% -4.83% -0.20% -34.51% 1.73% -8.06% 8.66% -15.00% 6.87% 15.65% -12.69% 8.18% 27.46% 11.52% 37.55% -5.24% 39.78% 5.09% 19.86% -18.47% 13.74% 4.68% 30.61% -10.49% 18.21% -1.14% 29.63% -4.09% 23.97% 21.32% 11.13%                                        
      less: cost of goods sold
    26,050,000 27,462,000 22,379,000 16,887,000 35,399,000 26,022,000 24,722,000 24,615,000 29,589,000 23,560,000 23,199,000 25,794,000 26,641,000 23,941,000 35,810,000 22,239,000 30,635,000 30,211,000 32,155,000 28,326,000 34,768,000 33,071,000 28,797,000 34,807,000 30,665,000 25,444,000 22,770,000 17,140,000 17,508,000 13,541,000 12,846,000 10,648,000 13,432,000 11,921,000 11,401,000 8,198,000 10,155,000 8,451,000 8,861,000 6,896,000 8,389,000 7,478,000 6,381,000 5,627,000 5,848,000 5,366,000 5,025,000 4,246,000                                   
      gross margin
    23,169,000 22,208,000 50,362,000 25,130,000 -9,567,000 16,276,000 42,769,000 31,904,000 45,124,000 29,822,000 42,668,000 47,927,000 63,604,000 62,859,000 43,630,000 72,391,000 113,856,000 111,827,000 122,333,000 113,844,000 132,483,000 123,428,000 106,520,000 120,186,000 112,612,000 86,964,000 78,022,000 56,138,000 59,822,000 41,782,000 39,797,000 33,271,000 40,434,000 35,439,000 33,840,000 26,439,000 28,541,000 24,283,000 24,250,000 18,647,000 18,244,000 14,005,000 11,326,000 10,306,000 10,632,000 8,783,000 7,581,000 6,721,000                                   
      yoy
    -342.18% 36.45% 17.75% -21.23% -121.20% -45.42% 0.24% -33.43% -29.05% -52.56% -2.20% -33.79% -44.14% -43.79% -64.34% -36.41% -14.06% -9.40% 14.85% -5.28% 17.65% 41.93% 36.53% 114.09% 88.25% 108.14% 96.05% 68.73% 47.95% 17.90% 17.60% 25.84% 41.67% 45.94% 39.55% 41.79% 56.44% 73.39% 114.11% 80.93% 71.60% 59.46% 49.40% 53.34%                                       
      qoq
    4.33% -55.90% 100.41% -362.67% -158.78% -61.94% 34.06% -29.30% 51.31% -30.11% -10.97% -24.65% 1.19% 44.07% -39.73% -36.42% 1.81% -8.59% 7.46% -14.07% 7.34% 15.87% -11.37% 6.73% 29.49% 11.46% 38.98% -6.16% 43.18% 4.99% 19.61% -17.72% 14.09% 4.73% 27.99% -7.36% 17.53% 0.14% 30.05% 2.21% 30.27% 23.65% 9.90% -3.07% 21.05% 15.86% 12.80%                                    
      gross margin %
    47.07% 44.71% 69.23% 59.81% -15.35% 38.48% 63.37% 56.45% 60.40% 45.15% 53.22% 55.75% 70.48% 69.94% 46.20% 76.50% 78.80% 78.73% 79.19% 80.08% 79.21% 78.87% 78.72% 77.54% 78.60% 77.36% 77.41% 76.61% 77.36% 75.52% 75.60% 75.76% 75.06% 74.83% 74.80% 76.33% 73.76% 74.18% 73.24% 73.00% 68.50% 65.19% 63.96% 64.68% Infinity% Infinity% Infinity% Infinity% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN%    
      operating expenses:
                                                                                      
      selling, general and administrative
    20,059,000 19,697,000 38,673,000 36,573,000 36,970,000 36,904,000 38,547,000 39,889,000 43,941,000 45,457,000 50,953,000 59,587,000 68,131,000 58,745,000 86,893,000 90,647,000 92,368,000 102,965,000 107,203,000 105,798,000 116,816,000 120,164,000 92,395,000 133,937,000 96,025,000 82,559,000 73,406,000 71,633,000 79,686,000 49,960,000 53,944,000 43,407,000 35,639,000 33,194,000 31,545,000 34,171,000 31,225,000 26,061,000 26,066,000 28,020,000 23,519,000 26,727,000 26,054,000 24,741,000 18,397,000 19,270,000 21,094,000 20,585,000 22,293,000 28,274,000 33,961,000 39,267,000                               
      research and development
    5,371,000 4,208,000 4,915,000 5,312,000 5,985,000 4,540,000 4,746,000 5,598,000 5,791,000 5,105,000 5,642,000 5,681,000 5,239,000 5,765,000 9,356,000 10,051,000 5,753,000 7,820,000 6,357,000 9,377,000 8,509,000 10,204,000 9,969,000 10,278,000 11,097,000 8,923,000 7,130,000 7,242,000 11,907,000 14,072,000 18,159,000 11,762,000 11,947,000 10,694,000 13,694,000 10,823,000 10,177,000 13,490,000 12,578,000 13,730,000 13,347,000 13,092,000 12,009,000 12,614,000 12,435,000 14,457,000 11,727,000 11,707,000 16,602,000 16,821,000 17,489,000 21,838,000 19,221,000 20,913,000 14,066,000 4,756,000 5,951,000 6,013,000 5,189,000 4,449,000  15,282,000  10,963 1,971 1,748 2,237 2,409 4,378 5,051  4,711  3,800 2,898 2,419       
      restructuring
    4,064,000 9,406,000 22,759,000      229,000 711,000 10,032,000  -180,000 3,493,000 10,213,000  -398,000 14,115,000                                                                 
      total operating expenses
    29,494,000 33,311,000 66,347,000 41,885,000 42,955,000 41,444,000 43,293,000 45,487,000 49,961,000 51,273,000 66,627,000 65,268,000 73,190,000 68,003,000 106,462,000 100,698,000 97,723,000 124,900,000 113,560,000 115,175,000 125,325,000 130,368,000 102,364,000 144,215,000 107,122,000 91,482,000 80,536,000 78,875,000 91,593,000 64,032,000 72,103,000 55,169,000 47,586,000 43,888,000 45,239,000 44,994,000 41,402,000 39,551,000 38,644,000 41,750,000 36,866,000 39,819,000 38,063,000 37,355,000 30,832,000 33,727,000 32,821,000 32,292,000 42,994,000 48,777,000 54,294,000 62,392,000 35,956,000 34,310,000 27,701,000 18,783,000 12,325,000 9,446,000 15,214,000 7,175,000    28,180 6,749 7,733 6,890 16,437 9,673 8,582  8,357  7,945 6,777 5,824       
      operating income
    -6,325,000 -11,103,000 -15,985,000 -16,755,000 -52,522,000 -25,168,000 -524,000 -13,583,000 -4,837,000 -21,451,000 -23,959,000 -17,341,000 -9,586,000 -5,144,000 -62,832,000 -28,307,000 16,133,000 -13,073,000 8,773,000 -1,331,000 7,158,000 -6,940,000 4,156,000 -24,029,000 5,490,000 -4,518,000 -2,514,000 -22,737,000 -31,771,000 -22,250,000 -32,306,000 -21,898,000 -7,152,000 -8,449,000 -11,399,000 -18,555,000 -12,861,000 -15,268,000 -14,394,000 -23,103,000 -18,622,000 -25,814,000 -26,737,000 -27,049,000 -20,200,000 -24,944,000 -25,240,000 -25,571,000 -32,888,000 -40,374,000 -48,794,000 -60,051,000 -35,956,000 -34,310,000 27,701,000 -18,783,000 -12,325,000 -9,446,000 15,214,000 -7,175,000  19,575,000           -14,722          
      yoy
    -87.96% -55.88% 2950.57% 23.35% 985.84% 17.33% -97.81% -21.67% -49.54% 317.01% -61.87% -38.74% -159.42% -60.65% -816.20% 2026.75% 125.38% 88.37% 111.09% -94.46% 30.38% 53.61% -265.31% 5.68% -117.28% -79.69% -92.22% 3.83% 344.23% 163.34% 183.41% 18.02% -44.39% -44.66% -20.81% -19.69% -30.94% -40.85% -46.16% -14.59% -7.81% 3.49% 5.93% 5.78% -38.58% -38.22% -48.27% -57.42% -8.53% 17.67% -276.15% 219.71% 191.73% 263.22% 82.08% 161.78%  -148.26%                         
      qoq
    -43.03% -30.54% -4.60% -68.10% 108.69% 4703.05% -96.14% 180.81% -77.45% -10.47% 38.16% 80.90% 86.35% -91.81% 121.97% -275.46% -223.41% -249.01% -759.13% -118.59% -203.14% -266.99% -117.30% -537.69% -221.51% 79.71% -88.94% -28.43% 42.79% -31.13% 47.53% 206.18% -15.35% -25.88% -38.57% 44.27% -15.76% 6.07% -37.70% 24.06% -27.86% -3.45% -1.15% 33.91% -19.02% -1.17% -1.29% -22.25% -18.54% -17.26% -18.75% 67.01% 4.80% -223.86% -247.48% 52.40% 30.48% -162.09% -312.04%                        
      operating margin %
    -12.85% -22.35% -21.98% -39.88% -84.30% -59.50% -0.78% -24.03% -6.47% -32.47% -29.89% -20.17% -10.62% -5.72% -66.53% -29.91% 11.17% -9.20% 5.68% -0.94% 4.28% -4.43% 3.07% -15.50% 3.83% -4.02% -2.49% -31.03% -41.08% -40.22% -61.37% -49.86% -13.28% -17.84% -25.20% -53.57% -33.24% -46.64% -43.47% -90.45% -69.92% -120.16% -151.00% -169.77% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% Infinity% -Infinity% -Infinity% -Infinity% Infinity% -Infinity% NaN% Infinity% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% -Infinity% NaN% NaN% NaN% NaN% NaN% NaN%    
      interest income
    2,576,000 2,783,000 2,620,000 2,872,000 3,375,000 3,374,000 3,271,000 3,383,000 3,425,000 3,216,000 3,001,000 2,221,000 1,578,000 750,000 288,000 203,000 301,000 163,000 285,000 471,000 2,993,000 549,000 151,000 1,208,000 8,261,000 1,146,000 789,000                          13,382,000 -4,570,000  -3,951,000 134,000 3,000  1,000                       
      other income
    2,904,000 205,000 -85,000 253,000 -753,000 265,000 145,000 1,545,000 -1,029,000 -575,000 3,043,000 624,000 1,250,000 511,000 -2,255,000 -246,000 88,000 -57,000 -191,000  54,000 33,000 108,000 -91,000    3,000 -192,000 -58,000 -131,000 55,000 -26,000 25,000 80,000 -5,000   -182,000 -121,000 -93,000 -102,000 95,000 -128,000 -267,000 -247,000 4,225,000 16,000 -351,000 -302,000 -411,000 -124,000 -16,000 -427,000  68,000 -40,000 -59,000  77,000                       
      loss from operations before taxes
    -852,000 -8,115,000  -13,630,000 -49,907,000 -21,529,000  -8,655,000 -12,805,250 -18,810,000 -17,915,000 -14,496,000 -24,258,000 -3,883,000      -1,002,000 7,600,000 -6,358,000  -22,912,000 7,232,000 -3,462,000 -1,820,000 -24,431,000 -33,573,000 -24,471,000 -34,210,000 -24,095,000     -15,307,250 -16,787,000 -14,382,000  -23,713,500 -31,207,000   -8,855,500 -25,601,000  -25,555,000    -65,415,000   51,000,000    200,468,000                        
      benefit from income taxes
    -594,500 377,000     -1,370,000                              583,000 1,015,000 1,028,000 289,000 1,545,000 532,000   -321,250 -449,000 -411,000 -425,000 -1,633,000 1,635,000 -65,000 3,257,000                               
      net income
    -1,224,000 -7,738,000 -14,139,000 -15,697,000 -48,618,000 -25,134,000 1,522,000 -9,953,000 -5,781,000 -19,311,000 -17,560,000 -16,460,000 856,000 -5,140,000 -69,956,000 -31,563,000 14,698,000 -13,151,000 7,808,000 -1,626,000 4,926,000 -6,788,000 4,415,000 -20,553,000 7,068,000 -3,462,000 -1,820,000 -24,431,000 -33,669,000 -24,471,000 -34,210,000 -24,095,000 -22,465,000 -10,825,000 -13,634,000 -20,941,000 -27,453,000 -15,772,000 -13,354,000 -29,771,000 -21,891,000 -30,675,000 -31,512,000 -31,126,000 -19,657,000 -26,050,000 15,323,000 -25,980,000 -15,411,000 -48,884,000 -39,774,000 -62,158,000 -10,567,000 -26,426,000 53,904,000 -88,285,000                           
      yoy
    -97.48% -69.21% -1028.98% 57.71% 741.00% 30.15% -108.67% -39.53% -775.35% 275.70% -74.90% -47.85% -94.18% -60.92% -995.95% 1841.14% 198.38% 93.74% 76.85% -92.09% -30.31% 96.07% -342.58% -15.87% -120.99% -85.85% -94.68% 1.39% 49.87% 126.06% 150.92% 15.06% -18.17% -31.37% 2.10% -29.66% 25.41% -48.58% -57.62% -4.35% 11.36% 17.75% -305.65% 19.81% 27.55% -46.71% -138.53% -58.20% 45.84% 84.98% -173.79% -29.59%                               
      qoq
    -84.18% -45.27% -9.93% -67.71% 93.44% -1751.38% -115.29% 72.17% -70.06% 9.97% 6.68% -2022.90% -116.65% -92.65% 121.64% -314.74% -211.76% -268.43% -580.20% -133.01% -172.57% -253.75% -121.48% -390.79% -304.16% 90.22% -92.55% -27.44% 37.59% -28.47% 41.98% 7.26% 107.53% -20.60% -34.89% -23.72% 74.06% 18.11% -55.14% 36.00% -28.64% -2.66% 1.24% 58.35% -24.54% -270.01% -158.98% 68.58% -68.47% 22.90% -36.01% 488.23% -60.01% -149.02% -161.06%                            
      net income margin %
    -2.49% -15.58% -19.44% -37.36% -78.03% -59.42% 2.26% -17.61% -7.74% -29.23% -21.90% -19.15% 0.95% -5.72% -74.07% -33.35% 10.17% -9.26% 5.05% -1.14% 2.95% -4.34% 3.26% -13.26% 4.93% -3.08% -1.81% -33.34% -43.54% -44.23% -64.98% -54.86% -41.71% -22.86% -30.14% -60.46% -70.95% -48.18% -40.33% -116.55% -82.20% -142.79% -177.96% -195.36% -Infinity% -Infinity% Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% Infinity% -Infinity% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN%    
      loss per ordinary share:
                                                                                      
      basic
    -22.5 -20                                                                                 
      diluted
    -22.5 -20                                                                                 
      weighted-average ordinary shares:
                                                                                      
      basic
    414,984 415,531,000 414,477,000 413,422 410,937 411,150 410,851 410,146 407,655 408,417 407,848 406,177 401,155 404,614 398,187 397,805 395,992 396,618 395,899 394,638 381,759 389,699 384,663 361,136 342,538 350,994 330,863 328,712 297,237 295,595 293,662 285,207 270,652 270,803 270,725 270,163 211,874 209,149 184,471 184,052 180,654 183,245 180,464 175,582 173,719 174,502 172,886 172,872 161,022     149,200  136,011  133,238  123,426                       
      diluted
    414,984 415,531,000 414,477,000 413,422 410,937 411,150 411,395 410,146 407,655 408,417 407,848 406,177 401,155 404,614 398,187 397,805 402,480 396,618 401,767 394,638 381,759 389,699 399,664 361,136 342,538 350,994 330,863 328,712 297,237 295,595 293,662 285,207 270,652 270,803 270,725 270,163 211,874 209,149 184,471 184,052 180,654 183,245 180,464 175,582 173,824 175,141 207,674 174,431 167,070     149,200  136,011  155,975  151,500                       
      income from operations before taxes
      -13,450,000    2,892,000        -64,799,000 -28,350,000 16,393,000 -12,967,000 8,867,000    4,415,000          -11,350,000 -10,825,000 -13,634,000 -20,941,000    -30,060,000   -32,049,000 -31,598,000   15,734,000      -40,682,250 -22,853,000  -88,875,000 -21,278,000 97,112,000  18,245,000                       
      provision for income taxes
      -689,000 -2,067,000 1,289,000 -3,605,000  -1,298,000 -3,332,000 -501,000                                           -1,472,000 -3,573,000 2,904,000  -588,000 -767,000 1,635,000                        
      earnings per ordinary share:
                                                                                      
      basic
      -30                                                                                
      diluted
      -30                                                                                
      loss per share:
                                                                                      
      basic
       -0.04 -0.12 -0.06  -0.02 -0.033 -0.05 -0.04 -0.04 -0.068 -0.01  -0.08 -0.005 -0.03   0.01 -0.02  -0.06 0.02 -0.01 -0.01 -0.07 -0.11 -0.08 -0.12 -0.08 -0.08 -0.04 -0.05 -0.08 -0.1 -0.08 -0.07 -0.16 -0.12 -0.18  -0.18 -0.11 -0.15  -0.15                -0.96  -0.72    -0.07  -0.09   -0.08        
      diluted
       -0.04 -0.12 -0.06  -0.02 -0.033 -0.05 -0.04 -0.04 -0.068 -0.01  -0.08 -0.005 -0.03   0.01 -0.02  -0.06 0.02 -0.01 -0.01 -0.07 -0.11 -0.08 -0.12 -0.08 -0.08 -0.04 -0.05 -0.08 -0.1 -0.08 -0.07 -0.16 -0.12 -0.18  -0.18 -0.11 -0.17  -0.15                -0.96  -0.72         -0.08        
      weighted-average shares:
                                                                                      
      basic
    414,984 415,531,000 414,477,000 413,422 410,937 411,150 410,851 410,146 407,655 408,417 407,848 406,177 401,155 404,614 398,187 397,805 395,992 396,618 395,899 394,638 381,759 389,699 384,663 361,136 342,538 350,994 330,863 328,712 297,237 295,595 293,662 285,207 270,652 270,803 270,725 270,163 211,874 209,149 184,471 184,052 180,654 183,245 180,464 175,582 173,719 174,502 172,886 172,872 161,022     149,200  136,011  133,238  123,426                       
      diluted
    414,984 415,531,000 414,477,000 413,422 410,937 411,150 411,395 410,146 407,655 408,417 407,848 406,177 401,155 404,614 398,187 397,805 402,480 396,618 401,767 394,638 381,759 389,699 399,664 361,136 342,538 350,994 330,863 328,712 297,237 295,595 293,662 285,207 270,652 270,803 270,725 270,163 211,874 209,149 184,471 184,052 180,654 183,245 180,464 175,582 173,824 175,141 207,674 174,431 167,070     149,200  136,011  155,975  151,500                       
      less: cost of goods sold - restructuring inventory
             12,674,000 14,300,000 12,254,000  3,078,000 15,000,000                                                                    
      earnings per share:
                                                                                      
      basic
                  -0.18    0.02    0.01                    -0.35    0.09                                    
      diluted
                  -0.18    0.02    0.01                    -0.35    0.08                                    
      income tax benefit
              355,000      -466,750 -184,000 -1,059,000 -624,000 482,250 -430,000  2,359,000                                                           
      income tax provision
               -1,964,000 -2,406,750 -1,257,000 -5,157,000 -3,213,000                                                                   
      other expense
                       -142,000     -45,500 -90,000 -95,000          -95,250 -78,000                 52,000    -11,000                        
      licensing revenue
                            1,233,000 158,000 426,000 547,000 245,000 350,000 106,000 142,000 384,000 309,000 293,000 293,000 293,000 293,000 296,000 236,000 231,000 163,000  375,000                                       
      interest expense
                               -1,697,000 -2,684,000 -2,163,000 -1,773,000 -2,252,000 -2,669,000 -2,401,000 -2,315,000 -2,381,000 -2,424,000 -5,051,000 -5,616,000 -5,586,000 -5,427,000 -5,061,000 -4,807,000 -4,885,000 -5,010,000 -4,876,000 -4,296,000 -4,393,000 -7,533,000 -8,441,000 -9,345,000 -8,860,000   4,317,000    -94,000                        
      gain on change in fair value of derivative liabilities
                                         3,610,000 5,810,000 -1,250,000 -740,000 -230,000 -600,000 464,000 1,602,000 4,466,000 3,011,000 4,393,000 26,651,000 -1,402,000 18,841,000 3,620,000                               
      loss on change in fair value of derivative liabilities
                                                                                      
      preferred stock purchase option
                                               -868,000                                       
      preferred stock beneficial conversion features
                                             -1,646,000                                         
      net loss applicable to common shareholders
                                        -14,724,250 -15,772,000 -13,354,000  -31,792,000 -32,321,000                                         
      preferred stock beneficial conversion feature
                                              -31,341,000                                        
      net income applicable to common shareholders
                                           -29,771,000   -62,853,000 -31,994,000                                       
      gain on extinguishment of debt
                                                  38,034,000                                    
      benefit from (benefit from) income taxes
                                              537,000 472,000                                       
      product revenues
                                                16,480,000 14,149,000 12,606,000 10,967,000 4,061,250 8,403,000 5,500,000 2,341,000                               
      cost of goods sold
                                                    4,099,000 3,682,000 2,844,000 1,287,000                               
      loss from operations before income taxes
                                                    -38,910,750 -50,519,000 -39,709,000                                
      loss per share:
                                                                                      
      basic and diluted
                                                    -0.24 -0.29 -0.26 -0.41   0.38    1.58                        
      weighted-average shares:
                                                                                      
      basic and diluted
                                                     170,187 150,694 150,430 144,017,000  140,550  130,247,000  128,360  100,239,000                      
      revenues
                                                                                      
      marketing, general and administrative
                                                        16,735,000 13,397,000 13,635,000 14,027,000 4,046,250 3,433,000 10,025,000 2,726,000                       
      gain on change in fair value of derivative liability
                                                        -17,171,500 16,454,000  -66,209,000 30,734,000 106,614,000  25,342,000                       
      income per share:
                                                                                      
      basic
                                                        -0.298 -0.18  -0.65 -0.17 0.72  0.15                       
      diluted
                                                        -0.298 -0.18  -0.65 -0.17 0.62  0.12                       
      loss on change in fair value of derivative liability
                                                          18,930,000    185,359,000                        
      benefit for income taxes
                                                           590,000    49,000                       
      net and comprehensive income
                                                            -21,866,000 96,345,000  18,294,000                       
      net and comprehensive loss
                                                              202,103,000                        
      revenue
                                                                         400  100           
      operating expenses
                                                                   28,180 6,749 7,733 6,890 16,437 9,673 8,582  8,357 14,722 7,945 6,777        
      general and administrative
                                                                 4,293,000                     
      finance income
                                                                 -499,000  9,627 6,915 -139 821 648 552              
      finance costs
                                                                 21,000                     
      loss before tax
                                                                 19,097,000                     
      income tax/
                                                                 34,000                     
      loss for the period attributable to equity holders of the parent
                                                                 19,131,000                     
      basic loss per ordinary share
                                                                 -190                     
      diluted loss per ordinary share
                                                                 -190                     
      shares used in calculation of basic and diluted loss per share
                                                                 98,828,575                     
      revenue:
                                                                                      
      total revenues
                                                                               500       
      selling, general & administrative
                                                                   11,423 3,842 3,222 3,112 3,779 3,996 2,891  2,912 5,990 3,160 2,830 2,584 4,752  2,962    
      amortisation of intangible assets
                                                                        169 170  169  168 169 169   288    
      share-based compensation
                                                                   4,633 936 865 1,541 1,465 1,130 470  565 1,166 817 349        
      reorganization costs
                                                                   1,161  1,898                 
      impairment of intangible assets
                                                                                      
      total research & development
                                                                   12,954 2,218 2,120 2,615 2,756 4,617 5,206  4,897  4,070 2,898 2,419       
      total selling, general & administrative
                                                                   15,226 4,531 5,613 4,275 13,681 5,056 3,376  3,460  3,875 3,530 3,405       
      total operating income
                                                                   -28,180                   
      finance expense
                                                                   -3,330 -109 -183                 
      loss before taxes
                                                                   -21,883                   
      income tax credit
                                                                   674 194 172 179 169 317 128  118  163 390        
      net loss for the period
                                                                   -21,209                   
      weighted average shares - basic
                                                                   22,064                   
      gross profit
                                                                         400  100           
      impairment of intangible fixed assets
                                                                       8,784               
      categorized as follows:
                                                                                      
      total operating
                                                                    -6,749 -7,733 -6,890 -16,437 -9,673       -5,324       
      profit/(loss) before taxes
                                                                    57                  
      net profit/(loss) for the period
                                                                    251                  
      weighted-average shares – basic
                                                                    20,118                  
      income/(loss) per share:
                                                                                      
      basic
                                                                    0.01                  
      weighted-average shares - diluted
                                                                    20,118                  
      diluted
                                                                    0.01                  
      amortization of intangible assets
                                                                            337    337      
      (loss) before taxes
                                                                     -8,055 -6,069 -15,789 -9,121              
      net (loss) for the period
                                                                     -7,883 -5,890 -15,620 -8,804              
      weighted-average shares – basic*
                                                                     11,013                 
      weighted-average shares: - basic
                                                                      97,566                
      (loss)/income per share: -
                                                                                      
      basic
                                                                      -0.06 -0.17 -0.1       -0.1       
      diluted
                                                                      -0.06 -0.17 -0.1       -0.1       
      weighted-average shares - basic
                                                                       92,948 90,484 88,326  81,412  81,202 78,307 54,085       
      (loss)/income per share:
                                                                                      
      basic
                                                                      -0.06 -0.17 -0.1       -0.1       
      diluted
                                                                      -0.06 -0.17 -0.1       -0.1       
      group restructuring
                                                                            531  531        
      operating income on ordinary activities before interest
                                                                         -8,182  -8,257  -7,945 -6,777        
      net interest receivable/
                                                                         1,555  884  970 33        
      income before taxes
                                                                         -6,627  -7,373  -6,975 -6,744        
      net income for the period
                                                                         -6,499  -7,255  -6,812 -6,354        
      loss per share:
                                                                                      
      basic
       -0.04 -0.12 -0.06  -0.02 -0.033 -0.05 -0.04 -0.04 -0.068 -0.01  -0.08 -0.005 -0.03   0.01 -0.02  -0.06 0.02 -0.01 -0.01 -0.07 -0.11 -0.08 -0.12 -0.08 -0.08 -0.04 -0.05 -0.08 -0.1 -0.08 -0.07 -0.16 -0.12 -0.18  -0.18 -0.11 -0.15  -0.15                -0.96  -0.72    -0.07  -0.09   -0.08        
      * see note 4
                                                                                      
      research & development
                                                                            6,698    3,862      
      unaudited
                                                                                      
      turnover
                                                                                      
      cost of sales
                                                                                      
      interest receivable and similar income
                                                                                      
      interest payable and similar charges
                                                                                      
      loss on ordinary activities before tax
                                                                                      
      tax on loss on ordinary activities
                                                                                     
      retained loss for the financial period
                                                                                      
      diluted loss per share
                                                                                      
      loss per share:
                                                                                      
      basic -
                                                                             -0.08         
      * see note 5 over page
                                                                                      
      revenues from continuing activities
                                                                               500       
      revenues from discontinued activities
                                                                                  1,017    
      cost of sales:
                                                                                      
      direct costs
                                                                                      
      cost of sales from discontinued activities
                                                                                  107    
      continuing activities
                                                                               500       
      discontinued activities
                                                                                      
      total gross profit
                                                                               500       
      company restructuring
                                                                               652       
      non recurring payment
                                                                                      
      operating expenses from continuing activities
                                                                               5,824 8,951  3,250    
      research & development from discontinued activities
                                                                                  1,383    
      selling, general & administrative from discontinued activities
                                                                                      
      other income - valeant settlement
                                                                                      
      operating expenses from discontinued activities
                                                                                      
      operating (loss) from continuing activities
                                                                               -5,324 -8,951      
      operating (loss) on discontinued activities
                                                                                      
      exceptional income/(expense) - discontinued activities
                                                                                      
      escrow proceeds of q4 2003 swedish disposal
                                                                                      
      (loss) on disposal of us operations and certain products
                                                                                      
      gain on settlement of debt on related sale of distribution rights
                                                                                    
      (loss)/profit on ordinary activities before interest
                                                                                      
      net interest (payable)/receivable and similar (charges)/credits
                                                                               -39       
      (loss)/income before taxes
                                                                               -5,363       
      income tax credit/
                                                                               163       
      dividend credit
                                                                                      
      net (loss)/income for the period
                                                                               -5,200       
      revenue from continuing activities
                                                                                      
      gross profit:
                                                                                      
      gross profit from discontinued activities
                                                                                  910    
      total gross profit:
                                                                                  910    
      total operating expenses from discontinued activities
                                                                                  2,958    
      total operating (loss) on discontinued activities
                                                                                      
      exceptional income — discontinued activities
                                                                                      
      escrow proceeds from disposal of swedish business
                                                                                      
      loss on disposal of us operations and certain products
                                                                                     
      gain on settlement of elan debt
                                                                                      
      profit on ordinary activities before interest from discontinued activities
                                                                                      
      discontinued operations
                                                                                      
      continuing operations
                                                                                      
      profit on disposal of swedish operations
                                                                                    
      profit on ordinary activities before tax
                                                                                      
      tax on profit on ordinary activities
                                                                                    
      retained profit for the financial period
                                                                                      
      basic profit per ordinary share
                                                                                      
      diluted profit per share
                                                                                      
      selling, general & administrative pre-exceptional item
                                                                                  1,575    
      adjustment to deferred consideration relating to distribution rights
                                                                                      
      total selling, general & administrative from discontinued activities
                                                                                  1,575    
      exceptional income - discontinued activities
                                                                                      
      escrow proceeds from disposal of swedish business in q4 2003
                                                                                  350    
      (loss) on ordinary activities before interest from discontinued activities
                                                                                      
      operating income/
                                                                                      
      operating profit
                                                                                      
      profit for the financial period
                                                                                      
      dividends — non-equity
                                                                                      
      earnings per ordinary share
                                                                                      
      diluted earnings per share
                                                                                      
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-11-10 2009-12-31 2009-12-09 2009-11-23 2009-07-01 2009-06-30 2008-12-31 2008-09-25 2008-06-30 2008-05-19 2007-12-31 2007-11-27 2007-11-20 2007-08-01 2007-06-30 2007-05-19 2007-05-10 2007-05-04 2006-12-31 2006-09-06 2005-12-31 2005-09-30 2004-12-31 2004-09-30 2004-02-09 2004-01-31 2003-09-30 2002-12-31 2001-12-31 2000-12-31 
                                                                                                 
        assets
                                                                                                 
        current assets:
                                                                                                 
        cash and cash equivalents
      134,660,000 122,802,000 147,877,000 119,524,000 121,038,000 156,944,000 215,924,000 213,944,000 199,252,000 270,814,000 232,995,000 191,412,000 217,666,000 240,498,000 228,001,000 219,151,000 219,454,000 222,875,000 327,016,000 290,994,000 186,964,000 207,207,000 214,007,000 329,045,000 644,588,000 673,207,000 221,771,000 211,089,000 249,227,000 81,892,000 102,257,000 129,049,000 73,637,000 79,086,000 85,464,000 96,076,000 98,251,000 117,562,000 72,491,000 81,363,000 106,961,000 118,976,000 136,050,000 161,195,000 119,539,000 135,435,000 150,528,000 164,278,000 191,514,000 225,885,000 149,426,000 201,780,000 260,242,000 215,110,000 250,255,000 245,822,000 116,602,000 125,855,000 131,446,000 129,482,000 31,442,000 37,745,000  1,635 11,239  1,635 11,239  26,340  18,303 198  27,610 27,610   36,802             
        restricted cash
      201,000 301,000 300,000 300,000 300,000 526,000 525,000 525,000 525,000 524,000 524,000 523,000 523,000 3,920,000 3,918,000 3,918,000 3,918,000 3,917,000 3,917,000 3,917,000 3,915,000 3,915,000 3,913,000 3,910,000 3,907,000 3,904,000 1,503,000 1,502,000 1,500,000 600,000 600,000 600,000 600,000 600,000 600,000 600,000 600,000 600,000 600,000 600,000 600,000 600,000 600,000 600,000 600,000 600,000 600,000 600,000 1,000,000 1,400,000 1,400,000 1,400,000                                        
        short-term investments
      167,929,000 163,785,000 150,827,000 162,263,000 173,182,000 148,788,000 90,739,000 94,235,000 121,407,000 49,848,000 79,919,000 112,959,000 91,695,000 63,203,000 85,232,000 143,406,000 234,674,000 256,267,000 181,910,000 223,742,000 313,969,000 354,655,000 336,273,000 213,190,000                                                                    
        accounts receivable
      126,832,000 127,309,000 119,130,000 106,734,000 122,279,000 112,642,000 123,691,000 115,806,000 133,563,000 122,400,000 122,730,000 133,236,000 130,990,000 123,379,000 143,942,000 110,234,000 163,653,000 149,361,000 182,259,000 151,275,000 154,574,000 147,292,000 124,985,000 158,288,000 116,430,000 103,583,000 95,398,000 79,485,000 66,523,000 47,648,000 50,309,000 39,180,000 45,318,000 34,610,000 37,475,000 29,450,000 19,985,000 17,504,000 17,639,000 15,019,000 13,826,000 11,239,000 9,943,000 8,545,000 7,842,000 6,667,000 6,364,000 4,025,000 3,645,000 3,721,000 2,267,000 3,441,000                                      4,960 2,856 
        inventory
      195,910,000 184,703,000 171,244,000 159,490,000 166,048,000 224,000,000 239,408,000 255,280,000 258,616,000 254,461,000 227,021,000 225,813,000 228,732,000 227,606,000 225,772,000 267,818,000 234,676,000 309,268,000 272,455,000 230,892,000 188,864,000 148,531,000 124,844,000 92,121,000 76,769,000 54,557,000 46,268,000 57,909,000 57,802,000 43,673,000 40,093,000 35,104,000 30,260,000 28,550,000 24,814,000 23,879,000 20,507,000 19,773,000 20,306,000 21,344,000 18,985,000 19,704,000 20,499,000 16,183,000      27,083,000 28,514,000 27,435,000 21,262,000 8,989,000                                      
        prepaid and other current assets
      24,350,000 29,434,000 17,441,000 24,750,000 12,552,000 7,316,000 31,552,000 8,142,000 11,618,000 19,464,000 43,306,000 19,878,000 19,492,000 27,914,000 32,259,000 28,092,000 22,352,000 21,345,000 28,426,000 29,696,000 30,947,000 26,945,000 23,589,000 20,760,000 13,311,000 12,859,000 7,103,000 5,334,000 2,945,000 2,935,000 2,878,000 3,618,000 3,455,000 4,185,000 2,076,000 4,785,000 6,983,000 5,741,000 5,476,000 6,105,000 3,152,000 4,689,000 1,308,000 2,293,000                                                
        total current assets
      649,882,000 628,334,000 606,819,000 573,061,000 595,399,000 650,216,000 701,839,000 687,932,000 724,981,000 717,511,000 706,495,000 683,821,000 689,098,000 686,520,000 719,124,000 772,619,000 878,727,000 963,033,000 995,983,000 930,516,000 879,233,000 888,545,000 827,611,000 817,314,000 855,005,000 848,110,000 372,043,000 355,319,000 377,997,000 202,402,000 196,137,000 207,551,000 153,270,000 147,031,000 150,429,000 154,790,000 146,326,000 161,180,000 116,512,000 124,431,000 143,524,000 156,142,000 169,334,000 189,750,000 145,281,000 158,039,000 177,981,000 194,147,000 219,402,000 262,562,000 184,714,000 242,044,000 285,694,000 228,742,000 257,221,000 251,323,000 118,972,000 128,069,000 132,582,000 130,567,000 33,113,000 38,609,000 56,052,000 4,026 16,140 16,140 4,026 16,140 29,096 29,096 21,728 21,728 372 24,059 30,407 30,407 21,728 31,354 39,591           28,578 16,423 
        property, plant and equipment
      12,000 13,000 14,000 15,000 16,000 24,000 49,000 81,000 114,000 147,000 179,000 187,000 874,000 999,000 1,137,000 1,281,000 1,425,000 1,569,000 1,713,000 1,862,000 2,016,000 2,166,000 2,316,000 2,466,000 2,361,000 2,124,000 858,000 57,000 63,000 69,000 17,000 20,000 28,000 39,000 52,000 69,000 78,000 102,000 137,000 172,000 243,000 266,000 296,000 339,000 381,000 424,000 472,000 523,000 579,000 646,000 706,000 766,000 811,000 796,000 621,000 492,000 432,000 73,000 65,000 73,000 88,000 119,000 128,000 464 595 595 464 595 527 527 595  635 643 643 595 632 314           1,530 960 
        long-term inventory
       9,106,000 39,586,000 57,404,000 64,740,000 74,023,000 71,294,000 74,225,000 77,615,000 91,792,000 122,318,000 143,730,000 163,620,000 187,964,000 210,252,000 141,052,000 121,254,000                                                                           
        operating lease right-of-use asset
      6,461,000 7,186,000 7,640,000 8,363,000 7,592,000 7,984,000 7,540,000 7,876,000 8,310,000 8,510,000 8,978,000 9,190,000 9,074,000 8,462,000 8,599,000 8,689,000 7,660,000 7,762,000 7,861,000 7,958,000 8,054,000 8,149,000 8,291,000 8,397,000 8,511,000 8,633,000 8,762,000 8,900,000                                                                
        other long-term assets
      1,055,000 1,109,000 1,135,000 1,174,000 1,213,000 1,250,000 1,287,000 1,324,000 1,360,000 1,395,000 1,604,000 1,638,000 458,000 456,000 456,000 456,000 456,000 456,000 456,000 456,000 432,000 1,074,000 1,074,000 1,074,000 1,074,000 1,074,000 1,102,000 643,000 174,000 174,000 174,000 174,000 174,000 174,000 173,000 652,000 741,000 682,000 174,000 174,000 2,045,000                                                   
        intangible asset
      13,365,000 14,066,000 14,932,000 15,660,000 16,389,000 17,118,000 17,846,000 18,575,000 19,304,000 19,676,000 20,377,000 21,078,000 21,780,000 21,638,000 22,274,000 22,911,000 23,547,000 24,183,000 24,820,000 25,456,000 13,817,000 14,177,000 14,538,000 14,898,000 15,258,000 6,996,000 7,157,000 7,319,000 7,480,000 7,642,000 7,803,000 7,964,000 8,126,000 8,287,000 8,449,000 8,610,000 8,772,000 8,933,000 9,095,000 9,256,000 9,417,000 9,579,000 9,740,000 9,902,000 10,063,000 10,225,000 10,386,000 10,548,000 10,709,000 10,870,000 11,032,000 11,193,000 11,355,000                                       
        total assets
      670,775,000 659,814,000 670,126,000 655,677,000 685,349,000 750,615,000 799,855,000 790,013,000 831,684,000 839,031,000 860,018,000 860,188,000 886,179,000 908,303,000 973,237,000 973,709,000 1,068,065,000 1,035,805,000 1,044,991,000 990,252,000 966,021,000 960,203,000 914,869,000 925,668,000 882,209,000 866,937,000 389,922,000 372,238,000 385,714,000 210,287,000 204,131,000 215,709,000 161,598,000 166,613,000 170,185,000 175,203,000 166,999,000 193,903,000 147,636,000 152,712,000 173,462,000 182,422,000 195,165,000 215,339,000 171,107,000 185,373,000 205,839,000 220,207,000 252,476,000 293,846,000 214,667,000 271,331,000 310,855,000 254,998,000 271,175,000 260,840,000 126,379,000 131,670,000 135,520,000 132,806,000 35,367,000 38,744,000 56,197,000 25,876 36,657 36,657 25,876 36,657 49,550 49,550 42,254 42,254 396 24,716 31,074 31,074 42,254 41,486 49,559   46,760,000  23,721,000      62,486 32,502 
        liabilities and stockholders’ equity
                                                                                                 
        current liabilities:
                                                                                                 
        accounts payable
      45,355,000 36,712,000 44,711,000 45,661,000 40,366,000 40,507,000 54,383,000 67,600,000 52,762,000 53,362,000 54,309,000 58,779,000 64,602,000 93,157,000 116,312,000 90,753,000 114,922,000 72,415,000 141,251,000 94,262,000 105,876,000 121,366,000 86,757,000 98,330,000 49,950,000 42,042,000 34,018,000 26,776,000 37,632,000 26,174,000 34,471,000 31,877,000 25,155,000 15,805,000 16,455,000 15,117,000 6,062,000 6,864,000 14,811,000 15,137,000 10,832,000 17,899,000 13,006,000 10,756,000 8,525,000 6,059,000 5,543,000 4,823,000 6,375,000 6,233,000 9,688,000 22,945,000 17,458,000 13,696,000 8,429,000 4,568,000 4,419,000 3,836,000 1,930,000 1,513,000 4,449,000                             2,075 1,226 
        accrued expenses and other current liabilities
      149,104,000 145,521,000 141,235,000 116,747,000 139,583,000 161,047,000 176,159,000 154,440,000 204,174,000 211,304,000 214,598,000 183,264,000 192,678,000 192,001,000 243,064,000 207,622,000 253,111,000 289,684,000 226,545,000 228,734,000 198,641,000 189,650,000 168,549,000 170,731,000 139,826,000 134,542,000 103,495,000 94,170,000 84,171,000 93,899,000 73,753,000 61,311,000 58,902,000 51,627,000 49,102,000 44,434,000 37,720,000 38,334,000 31,052,000 24,551,000 24,226,000 22,503,000 21,004,000 17,675,000 16,268,000 15,365,000 13,205,000  9,594,000                                           
        total current liabilities
      194,459,000 182,233,000 185,946,000 162,408,000 179,949,000 201,554,000 230,542,000 224,381,000 259,277,000 266,691,000 270,932,000 244,242,000 259,479,000 287,356,000 361,574,000 300,573,000 370,682,000 364,745,000 370,439,000 325,769,000 307,443,000 326,189,000 283,467,000 310,327,000 242,248,000 229,712,000 184,885,000 161,804,000 157,263,000 151,642,000 137,637,000 119,230,000 108,530,000 90,070,000 86,292,000 77,944,000 76,249,000 75,114,000 77,851,000 53,587,000 50,723,000 55,320,000 50,271,000 42,533,000 40,306,000 35,335,000 37,930,000 31,362,000 37,540,000 31,299,000 35,434,000 42,391,000 25,202,000 32,512,000 17,499,000 9,584,000 8,452,000 6,428,000 3,773,000 3,920,000 7,577,000 5,876,000 6,693,000 9,752 7,108 7,108 9,752 7,108 8,553 8,553 15,412 15,412 215 8,469 10,243 10,243 15,412 10,202            36,902 3,037 
        long-term liabilities:
                                                                                                 
        long-term operating lease liability
      6,080,000 6,731,000 7,338,000 7,940,000 7,723,000 8,215,000 8,099,000 8,389,000 8,737,000 8,970,000 9,472,000 9,841,000 10,015,000 9,924,000 10,174,000 10,398,000 8,576,000 8,729,000 8,875,000 9,015,000 9,153,000 9,255,000 9,311,000 9,381,000 9,443,000 9,432,000 8,160,000 7,930,000                                                                
        other long-term liabilities
      10,955,000 11,956,000 11,918,000 11,642,000 11,501,000 9,471,000 9,335,000 9,199,000 9,064,000 7,273,000 7,155,000 8,610,000 8,205,000 9,697,000 7,636,000 7,490,000 7,648,000 5,350,000 5,528,000 5,660,000 6,214,000 4,303,000 4,821,000 2,665,000 3,751,000 5,402,000 6,813,000 8,030,000 10,523,000 8,652,000 6,764,000 1,150,000 1,150,000 1,158,000 1,158,000 1,167,000 710,000 731,000 268,000 300,000 335,000 608,000 626,000 631,000 386,000 640,000 619,000 632,000 658,000 811,000 795,000   702,000 704,000                                     
        total liabilities
      211,494,000 200,920,000 205,202,000 181,990,000 199,173,000 219,240,000 247,976,000 244,077,000 279,587,000 285,883,000 290,890,000 275,395,000 290,846,000 320,476,000 393,194,000 332,600,000 400,966,000 393,310,000 399,667,000 355,641,000 338,516,000 352,946,000 312,106,000 339,892,000 273,946,000 271,041,000 240,835,000 231,367,000 233,384,000 263,113,000 250,818,000 232,366,000 226,698,000 212,722,000 208,949,000 203,972,000 176,057,000 178,726,000 312,052,000 308,848,000 302,653,000 293,513,000 286,517,000 277,163,000 259,555,000 254,614,000 255,816,000 277,801,000 286,332,000 311,543,000 309,001,000 331,417,000 314,852,000 254,960,000 265,855,000 325,254,000 132,341,000 162,005,000 290,235,000 179,255,000 237,734,000 6,141,000 7,595,000 11,852 7,759 7,759 11,852 7,759 10,450 10,450 18,105 18,105  8,554 10,335 10,335 18,105 10,382 10,756           42,114 11,656 
        commitments and contingencies
                                                                                                 
        stockholders’ equity:
                                                                                                 
        ordinary shares, £0.50 par, unlimited authorized; 429,847,579 shares issued, 416,214,102 shares outstanding at december 31, 2025; 422,256,900 shares issued, 411,584,851 shares outstanding at december 31, 2024
      310,184,000                                                                                           
        additional paid-in capital
      1,923,801,000 1,922,351,000 1,920,993,000 1,916,223,000 1,914,750,000 1,911,445,000 1,906,903,000 1,902,698,000 1,899,456,000 1,895,155,000 1,891,957,000 1,890,496,000 1,885,352,000 1,878,923,000 1,869,770,000 1,861,017,000 1,855,246,000 1,845,103,000 1,834,548,000 1,831,388,000 1,817,649,000 1,799,069,000 1,787,492,000 1,774,671,000 1,764,317,000 1,745,946,000 1,311,965,000 1,301,389,000 1,282,762,000 1,057,408,000 1,040,743,000 1,036,697,000 977,866,000 974,343,000 970,797,000 967,073,000 964,914,000 961,691,000 822,013,000 818,591,000 816,171,000 812,409,000 802,846,000 769,533,000 738,890,000 738,440,000 733,113,000 740,819,000 738,754,000 739,524,000 630,565,000 625,086,000 619,266,000 613,087,000 593,341,000 478,757,000 449,393,000 443,399,000 417,413,000 329,186,000 206,718,000                               
        treasury stock
      -67,360,000 -67,356,000 -67,108,000 -66,445,000 -65,326,000 -65,344,000 -65,276,000 -65,188,000 -63,752,000 -63,743,000 -63,464,000 -63,277,000 -61,770,000 -61,585,000 -61,419,000 -61,261,000 -60,726,000 -59,602,000 -59,011,000 -58,334,000 -51,082,000 -50,728,000 -50,252,000 -49,731,000 -35,900,000 -20,533,000 -20,533,000 -19,493,000 -10,413,000 -9,867,000 -6,909,000 -6,782,000 -4,229,000 -4,054,000 -3,902,000 -3,726,000 -1,498,000 -1,350,000 -1,197,000 -1,105,000 -411,000 -368,000 -334,000 -334,000 -217,000 -217,000 -217,000 -217,000 -217,000 -217,000 -217,000 -217,000 -217,000 -217,000 -217,000 -217,000 -217,000 -217,000 -217,000 -217,000 -217,000                               
        accumulated deficit
      -1,707,344,000 -1,706,120,000 -1,698,382,000 -1,684,243,000 -1,668,546,000 -1,619,928,000 -1,594,794,000 -1,596,316,000 -1,586,363,000 -1,580,582,000 -1,561,271,000 -1,543,711,000 -1,527,251,000 -1,528,107,000 -1,522,967,000 -1,453,011,000 -1,421,448,000 -1,436,146,000 -1,422,995,000 -1,430,803,000 -1,429,177,000 -1,434,103,000 -1,427,315,000 -1,431,730,000 -1,411,177,000 -1,418,245,000 -1,414,783,000 -1,412,963,000 -1,388,532,000 -1,354,863,000 -1,330,392,000 -1,296,182,000 -1,271,869,000 -1,249,404,000 -1,238,579,000 -1,224,945,000 -1,204,004,000 -1,176,551,000 -1,160,779,000 -1,149,064,000 -1,119,293,000 -1,097,402,000 -1,065,081,000 -1,002,228,000 -970,234,000 -950,577,000 -924,527,000 -939,850,000 -913,870,000 -898,459,000 -849,575,000 -809,801,000 -747,643,000 -737,076,000 -710,648,000 -656,744,000 -568,459,000 -586,797,000 -683,142,000 -481,039,000 -499,333,000                             -28,549 -25,133 
        total stockholders’ equity
      459,281,000 458,894,000 464,924,000 473,687,000 486,176,000 531,375,000 551,879,000 545,936,000 552,097,000 553,148,000 569,128,000 584,793,000 595,333,000 587,827,000 580,043,000 641,109,000 667,099,000 642,495,000 645,324,000 634,611,000 627,505,000 607,257,000 602,763,000 585,776,000 608,263,000 595,896,000 149,087,000 140,871,000 152,330,000         15,177,000                38,000 5,320,000                                     
        total liabilities and stockholders’ equity
      670,775,000 659,814,000 670,126,000 655,677,000 685,349,000 750,615,000 799,855,000 790,013,000 831,684,000 839,031,000 860,018,000 860,188,000 886,179,000 908,303,000 973,237,000 973,709,000 1,068,065,000 1,035,805,000 1,044,991,000 990,252,000 966,021,000 960,203,000 914,869,000 925,668,000 882,209,000 866,937,000 389,922,000 372,238,000 385,714,000         193,903,000                254,998,000 271,175,000                                     
        ordinary shares, £0.50 par value per share, unlimited authorized; 429,597,419 shares issued, 415,965,977 shares outstanding as of september 30, 2025; 422,256,900 shares issued, 411,584,851 shares outstanding as of december 31, 2024
       310,019,000                                                                                          
        ordinary shares, £0.50 par value per share, unlimited authorized; 428,714,819 shares issued, 415,401,497 shares outstanding as of june 30, 2025; 422,256,900 shares issued, 411,584,851 shares outstanding as of december 31, 2024
        309,421,000                                                                                         
        ordinary shares, £0.50 par value per share, unlimited authorized; 426,842,579 shares issued, 414,365,189 shares outstanding as of march 31, 2025; 422,256,900 shares issued, 411,584,851 shares outstanding as of december 31, 2024
         308,152,000                                                                                        
        current deferred revenue
             2,341,000 2,341,000 2,025,000 2,025,000 2,199,000 2,199,000 2,198,000 2,198,000 2,198,000 2,649,000 2,646,000 2,643,000 2,773,000 2,926,000                                                                       
        long-term deferred revenue
             2,108,000 2,509,000 2,949,000 3,331,000 12,702,000 13,147,000 13,499,000 13,810,000 14,139,000 14,060,000 14,486,000 14,825,000 15,197,000 15,706,000                                                                       
        common stock
          305,298,000 305,202,000 305,046,000 304,742,000 302,756,000 302,318,000 301,906,000 301,285,000 299,002,000 298,596,000 294,659,000 294,364,000 294,027,000 293,140,000 292,782,000 292,360,000 290,115,000 287,585,000 285,672,000 270,716,000 269,173,000 266,878,000 250,588,000 250,088,000 246,663,000 232,646,000 225,507,000 225,246,000 208,768,000 208,642,000 208,556,000 208,465,000 207,166,000 207,023,000 151,183,000 151,078,000 149,978,000 149,906,000 149,842,000 145,026,000 143,113,000 143,113,000 141,654,000 141,654,000 141,477,000 141,455,000 124,893,000 124,846,000 124,597,000 124,244,000 122,844,000 113,790,000 113,321,000 113,280,000 111,231,000 105,621,000 90,465,000                               
        long-term investments
                67,000 544,000 1,275,000 2,264,000 11,395,000 26,701,000 34,996,000 38,802,000 14,158,000 24,004,000 62,469,000 46,092,000 61,039,000 81,519,000                                                                    
        debt from royalty-bearing instrument
                           9,467,000 22,455,000 36,978,000                                                                    
        series a convertible preferred stock, £0.05 par, unlimited authorized; nil shares issued and nil outstanding at december 31, 2020 and 289,317,460 shares issued and outstanding at december 31, 2019
                                                                                                 
        deferred revenue, current
                           5,706,000 5,706,000 4,288,000 2,342,000 1,962,000 1,962,000 1,898,000 1,220,000 1,220,000 1,056,000 1,453,000 1,644,000 2,222,000 1,447,000 1,197,000 1,172,000 1,172,000 1,172,000 1,172,000 923,000 923,000 856,000                                                 
        deferred revenue, long-term
                           13,199,000 14,507,000 17,519,000 18,504,000 17,617,000 17,775,000 18,265,000 19,490,000 19,736,000 17,750,000 17,459,000 17,192,000 16,997,000 13,332,000 13,625,000 13,943,000 14,236,000 14,529,000 14,822,000 13,308,000 13,538,000 13,769,000                                                 
        series a convertible preferred stock, £0.05 par, unlimited authorized; 23,850,780 shares issued and outstanding as of september 30, 2020
                           5,434,000                                                                      
        series a convertible preferred stock, £0.05 par, unlimited authorized; 51,603,780 shares issued and outstanding as of june 30, 2020
                            7,166,000                                                                     
        series a convertible preferred stock, £0.05 par, unlimited authorized; 289,317,460 shares issued and outstanding as of march 31, 2020 and december 31, 2019
                             21,850,000                                                                    
        current portion of long-term debt from royalty-bearing instrument
                              50,130,000 51,166,000 45,410,000 38,960,000 34,240,000 30,130,000 27,876,000 24,370,000 22,348,000 20,197,000 18,833,000 17,004,000 15,944,000 13,471,000                                                      
        long-term debt from royalty-bearing instrument
                               8,878,000 23,202,000 35,338,000 46,108,000 53,924,000 59,564,000 65,480,000 70,834,000 75,559,000 79,283,000 82,405,000 85,155,000 88,645,000                                                      
        series a convertible preferred stock, £0.05 par, unlimited authorized; 289,317,460 shares issued and outstanding as of december 31, 2019 and december 31, 2018
                              21,850,000                                                                   
        series a convertible preferred stock, £0.05 par, unlimited authorized; 289,317,460 shares issued and outstanding as of september 30, 2019 and december 31, 2018
                               21,850,000                                                                  
        series a convertible preferred stock, £0.05 par, unlimited authorized; 289,317,460 shares issued and outstanding as of june 30, 2019 and december 31, 2018
                                21,850,000                                                                 
        series a convertible preferred stock, £0.05 par, unlimited authorized; 289,317,460 shares issued and outstanding as of march 31, 2019 and december 31, 2018
                                 21,850,000                                                                
        current portion of exchangeable senior notes, net of discount
                                   219,000 481,000 219,000 481,000 219,000 455,000 192,000 15,351,000 15,273,000                                                      
        exchangeable senior notes, net of discount
                                   29,159,000 29,103,000 29,047,000 28,992,000 28,938,000 28,884,000 28,831,000   125,644,000 138,703,000 138,605,000 126,108,000 124,629,000 123,192,000 121,846,000                                               
        stockholders’ equity
                                                                                                 
        series a convertible preferred stock, £0.05 par, unlimited authorized; 289,317,460 shares issued and outstanding as of december 31, 2018
                                  21,850,000                                                               
        other receivables
                                   25,654,000                                                              
        liabilities and stockholders’ deficit
                                                                                                 
        stockholders’ deficit:
                                                                                                 
        series a convertible preferred stock, £0.05 par, unlimited authorized; 289,317,460 shares issued and outstanding as of september 30, 2018
                                   21,850,000                                                              
        total stockholders’ deficit
                                   -52,826,000 -46,687,000 -16,657,000 -65,100,000 -46,109,000 -38,764,000 -28,769,000 -9,058,000  -164,416,000 -156,136,000 -129,191,000 -111,091,000 -91,352,000 -61,824,000 -88,448,000 -69,241,000 -49,977,000 -57,594,000 -33,856,000 -17,697,000 -94,334,000 -60,086,000 -3,997,000   -64,414,000 -5,962,000 -30,335,000                                  
        total liabilities and stockholders’ deficit
                                   210,287,000 204,131,000 215,709,000 161,598,000 166,613,000 170,185,000 175,203,000 166,999,000  147,636,000 152,712,000 173,462,000 182,422,000 195,165,000 215,339,000 171,107,000 185,373,000 205,839,000 220,207,000 252,476,000 293,846,000 214,667,000 271,331,000 310,855,000   260,840,000 126,379,000 131,670,000                                  
        series a convertible preferred stock, £0.05 par, unlimited authorized; 328,184,640 shares issued and outstanding as of june 30, 2018 and december 31, 2017
                                    24,364,000                                                             
        series a convertible preferred stock, £0.05 par, unlimited authorized; 328,184,640 shares issued and outstanding as of march 31, 2018 and december 31, 2017
                                     24,364,000                                                            
        deferred tax assets
                                       11,082,000 11,082,000 11,082,000 11,082,000 23,006,000 21,718,000 18,679,000  934,000 934,000 934,000 934,000 471,000 471,000  471,000                                           
        series a convertible preferred stock, £0.05 par, unlimited authorized; 328,184,640 shares issued and outstanding as of december 31, 2017 and december 31, 2016
                                      24,364,000                                                           
        series a convertible preferred stock, £0.05 par, unlimited authorized; 328,184,640 shares issued and outstanding as of september 30, 2017 and december 31, 2016
                                       24,364,000                                                          
        series a convertible preferred stock, £0.05 par, unlimited authorized; 328,184,640 shares issued and outstanding as of june 30, 2017 and december 31, 2016
                                        24,364,000                                                         
        series a convertible preferred stock, £0.05 par, unlimited authorized; 328,184,640 shares issued and outstanding as of march 31, 2017 and december 31, 2016
                                         24,364,000                                                        
        long-term debt derivative liabilities
                                            3,610,000 9,420,000 8,170,000 6,930,000 6,700,000 6,100,000 7,400,000 9,000,000 9,400,000                                             
        series a convertible preferred stock, £0.05 par, unlimited authorized; 328,184,640 issued and outstanding as of december 31, 2016 and 2015
                                          24,364,000                                                       
        series a convertible preferred stock, £0.05 par, unlimited authorized; 328,184,640 shares issued and outstanding as of september 30, 2016 and december 31, 2015
                                           24,364,000                                                      
        current portion of long-term debt
                                            30,816,000 12,727,000 14,742,000 13,995,000 15,405,000 14,102,000 15,394,000 13,790,000                                              
        long-term debt
                                            90,150,000 92,016,000 91,512,000 91,009,000 90,522,000 90,082,000 89,617,000 89,152,000 88,700,000 88,207,000 87,717,000 87,319,000 86,687,000                                        419 
        series a convertible preferred stock, £0.05 par, unlimited authorized; 328,184,640 shares issued and outstanding as of june 30, 2016 and december 31, 2015
                                            24,364,000                                                     
        series a convertible preferred stock, £0.05 par, unlimited authorized; 328,184,640 shares issued and outstanding as of march 31, 2016 and december 31, 2015
                                             24,364,000                                                    
        deferred tax assets, current
                                                                                                 
        deferred tax assets, long-term
                                              18,233,000                                                   
        series a convertible preferred stock, £0.05 par, unlimited authorized; 328,184,640 issued and outstanding as of december 31, 2015 (equivalent to 32,818,464 ordinary shares upon future consolidation and redesignation at a 10:1 ratio); zero shares issued and outstanding as of december 31, 2014
                                              24,364,000                                                   
        other non-current assets
                                               2,297,000 2,508,000 2,697,000 2,826,000 4,823,000 5,063,000 3,021,000 4,360,000 5,335,000 5,335,000 5,335,000 4,951,000     3,528,000 2,873,000              18                   
        series a convertible preferred stock, £0.05 par, unlimited authorized; 328,184,640 issued and outstanding as of september 30, 2015 (equivalent to 32,818,464 ordinary shares upon future consolidation and redesignation at a 10:1 ratio); zero shares issued and outstanding as of december 31, 2014
                                               24,364,000                                                  
        series a convertible preferred stock, £0.05 par, unlimited authorized; 289,317,460 issued and outstanding as of june 30, 2015 (equivalent to 28,931,746 ordinary shares upon future consolidation and redesignation at a 10:1 ratio); zero shares issued and outstanding as of december 31, 2014
                                                21,375,000                                                 
        deferred revenue
                                                 14,625,000     1,703,000 1,617,000 1,833,000 2,865,000                                        
        series a convertible preferred stock, £0.05 par, unlimited authorized; 352,150,790 issued and outstanding at march 31, 2015 (equivalent to 35,215,079 ordinary shares upon future consolidation and redesignation at a 10:1 ratio); zero shares issued and outstanding at december 31, 2014
                                                 26,179,000                                                
        inventory, current
                                                  13,733,000 11,886,000 17,143,000 21,830,000 21,209,000                                           
        other current assets
                                                  2,633,000 2,980,000 2,875,000 2,943,000 1,563,000 3,537,000 2,171,000 7,051,000 3,253,000 4,110,000 6,433,000 4,968,000 1,837,000 2,214,000 1,136,000 1,085,000 1,063,000 446,000 2,602,000 1,165 1,227 1,227 1,165 1,227 1,500 1,500 1,721 1,721 174 1,753 1,434 1,434 1,721 1,216 1,172             
        inventory, long-term
                                                                                                 
        warrant derivative liability
                                                  119,000 121,000 4,513,000 5,929,000  39,598,000 36,028,000 49,011,000 54,854,000 90,963,000 120,214,000 191,387,000 123,125,000 155,018,000 285,984,000 174,819,000 230,069,000                               
        exchangeable senior notes
                                                   120,487,000 119,167,000 150,000,000 149,317,000 145,316,000 141,457,000 137,735,000 134,250,000                                       
        accrued interest payable
                                                    14,669,000 12,569,000 12,974,000 10,901,000 9,555,000 4,646,000 2,520,000                                       
        deferred tax asset
                                                     471,000  936,000 936,000 937,000 937,000 533,000 533,000 533,000 533,000   2,166,000 608,000                               
        accrued expenses and other liabilities
                                                     8,041,000  12,548,000 14,358,000 11,935,000 5,224,000 18,816,000 9,070,000 5,016,000 4,033,000 2,592,000 1,843,000 2,407,000 3,128,000 1,769,000 3,838,000 2,828 3,782  2,828 3,782  4,578  6,733 109  7,919 7,919   8,660             
        long-term debt redemption feature
                                                     7,600,000 11,100,000 7,200,000 8,600,000                                         
        inventory, long term
                                                      5,482,000                                           
        warrant derivative liability, current
                                                      6,894,000                                           
        warrant derivative liability, long-term
                                                                                                 
        long- term debt
                                                         85,873,000                                        
        long- term debt redemption feature
                                                         15,600,000                                        
        other long term liabilities
                                                         807,000 816,000                                       
        long term debt
                                                          85,153,000 130,783,000 127,438,000                                     
        long term debt redemption feature
                                                          14,577,000                                       
        other long term assets
                                                           15,672,000 2,482,000 1,657,000 2,241,000                                   
        liabilities and stockholders’ (deficit) equity
                                                                                                 
        long term debt and other long-term liabilities
                                                             124,283,000                                    
        lease obligations and other long-term liabilities
                                                              764,000 559,000 478,000 516,000 88,000                               
        liabilities and stockholders’
                                                                                                 
        stockholders’
                                                                                                 
        total stockholders’
                                                                -154,715,000 -46,449,000                                
        total liabilities and stockholders’
                                                                135,520,000 132,806,000                                
        revenues
                                                                                                 
        operating expenses:
                                                                                                 
        research and development
                                                                5,189,000 4,449,000                                
        marketing, general and administrative
                                                                10,025,000 2,726,000                                
        total operating expenses
                                                                15,214,000 7,175,000                                
        operating income
                                                                15,214,000 -7,175,000                                
        loss on change in fair value of derivative liability
                                                                185,359,000                                 
        interest income
                                                                -94,000 1,000                                
        other income
                                                                -11,000 77,000                                
        income from operations before taxes
                                                                200,468,000 18,245,000                                
        benefit from income taxes
                                                                1,635,000                                 
        net and comprehensive loss
                                                                202,103,000                                 
        loss per share:
                                                                                                 
        basic and diluted
                                                                1,580                                 
        weighted-average shares:
                                                                                                 
        gain on change in fair value of derivative liability
                                                                 25,342,000                                
        benefit for income taxes
                                                                 49,000                                
        net and comprehensive income
                                                                 18,294,000                                
        income per share:
                                                                                                 
        basic
                                                                 150                                
        diluted
                                                                 120                                
        stockholders’ (deficit) equity:
                                                                                                 
        total stockholders’ (deficit) equity
                                                                  -202,367,000                               
        total liabilities and stockholders’ (deficit) equity
                                                                  35,367,000                               
        non-current assets
                                                                                                 
        investment available for sale
                                                                   16,000                              
        total non-current assets
                                                                   135,000 145,000 21,850 20,517  21,850 20,517  20,454  20,526 24  667 667   9,968             
        current assets
                                                                                                 
        current tax recoverable
                                                                   418,000 1,192,000 1,226 674  1,226 674  1,256  1,704   1,363 1,363   1,617             
        equity
                                                                                             2,982 -10,062   
        capital and reserves attributable to owners of the parent
                                                                                                 
        share capital
                                                                   84,698,000 83,930,000 25,928 25,928 25,928 25,928 25,928 25,928 25,928 12,942  8,691 8,691 8,691 12,942 7,991 7,990             
        share premium
                                                                   189,063,000 188,337,000 152,864 152,273  152,864 152,273  152,378  147,171 9,224  139,938 139,938   139,313             
        share based payment reserve
                                                                   24,623,000 22,793,000 21,118 19,564  21,118 19,564  16,877  10,175 543  7,419 7,419   4,824             
        capital redemption reserve
                                                                   27,633,000 27,633,000 27,633 27,633  27,633 27,633  27,633  27,633   27,633 27,633   27,633 27,633 27,633  27,633  27,634       
        treasury shares
                                                                   -217,000  -217 -217  -217 -217  -217  -217   -217 -217   -217 -217 -217  -217         
        foreign currency translation adjustment
                                                                   -2,764,000  -2,254   -2,254   -1,719     -1,926 -1,926   -1,261             
        retained deficit
                                                                   -290,433,000                              
        total shareholders’ equity
                                                                   32,603,000 48,602,000 14,024 28,898  14,024 28,898  39,100  24,149   20,739 20,739              20,372 20,846 
        liabilities
                                                                                                 
        non-current liabilities
                                                                                                 
        provisions
                                                                   260,000 890,000 614 627 627 614 627 374 374 606 606     606 81 119             
        other liabilities
                                                                   5,000 12,000 28 24 24 28 24 30 30 36 36  85 92 92 36 99 116             
        total non-current liabilities
                                                                   265,000 902,000 2,100 651 651 2,100 651 1,897 1,897 2,693 2,693 19 85 92 92 2,693 180 235             
        current liabilities
                                                                                                 
        trade payables
                                                                   3,801,000 2,457,000 1,627 1,955 1,955 1,627 1,955 1,604 1,604 3,462 3,462 106 1,832 2,324 2,324 3,462 1,435 2,096             
        total shareholders’ equity & liabilities
                                                                   38,744,000                              
        intangible assets
                                                                     21,374 19,916  21,374 19,916 19,916 19,916  19,916       9,636 8,953 9,290  9,965  3,755   44,747 29,477   
        available for sale investment
                                                                    17,000 12  12  11 11 15   22 24 24 15 20 18             
        cash on short term deposits
                                                                                                 
        cash
                                                                    52,258,000   14,239   26,340  18,303   20,735   18,303 28,969            20,688 1,348 
        capital and reserves attributable to owners of the parent holders of the company
                                                                                                 
        equity component of 8% convertible debt
                                                                           145  145                    
        retained earnings
                                                                     -220,326 -203,766  -220,326 -203,766  -191,843  -185,192   -171,419 -171,419   -149,723             
        borrowings
                                                                     1,439   1,439                         
        derivative financial liability
                                                                           1,493                      
        current derivative financial liabilities
                                                                     3,565   3,565                         
        total shareholders’ equity and liabilities
                                                                    56,197,000 25,876 36,657  25,876 36,657  49,550  42,254                    
        capital and reserves attributable to equity holders of the company
                                                                                                 
        warrant reserve
                                                                     9,278 9,918  9,278 9,918  9,918  13,328   10,614 10,614   10,009             
        financial liability
                                                                     1,458   1,458  1,493                       
        investments in subsidiaries
                                                                                                 
        available for sale investments
                                                                           15                    
        cash on short-term deposits
                                                                      3,000   3,000                        
        other current derivative financial liabilities
                                                                      1,037   1,037  1,910                      
        foreign currency translation reserve
                                                                      -2,435   -2,435    -1,836                    
        selected balance sheet data
                                                                                                 
        intangible fixed assets
                                                                       19,916     19,916      19,916 9,480              
        income tax recoverable
                                                                       674   1,256  1,704   1,571   1,704 1,169              
        convertible debt
                                                                            2,051      2,051               
        accrued expenses & other liabilities
                                                                       4,819   6,488  6,733   6,637   6,733 8,767              
        capital and reserves attributable to equity holders
                                                                                                 
        other reserves
                                                                       2,970   13,172  11,207   7,471   11,207 23,113              
        total shareholders' equity and liabilities
                                                                       36,657   49,550  42,254   24,716 31,074 31,074 42,254 41,486 49,559             
        1. selected balance sheet data
                                                                                                 
        non-current assets - sum
                                                                          20,454  20,526                     
        2. the selected financial data set out in this press release should be read in conjunction with our 2007 ifrs annual report on form 20-f which was filed with the sec on may 19, 2008.
                                                                                                 
        3. loss per share
                                                                                                 
        effective january 18, 2008 our ordinary shares were consolidated on a one-for-ten basis whereby ten ordinary shares of 5p each became one ordinary share of 50p. shares and share related information (such as loss per share information) reflect this one-for-ten ordinary share consolidation.
                                                                                                 
        4. non-current assets - intangible assets
                                                                                                 
        intangible assets of 19,916,000 relate to the acquisition of ester neurosciences limited on december 5, 2007 representing the upfront acquisition consideration already satisfied in cash and shares in december 2007 plus 4,756,000 of a provision relating to a future contingent milestone, likely payable during 2008. this milestone is payable in cash or shares, at amarin’s option (see note 6 below).
                                                                                                 
        5. non-current liabilities – convertible debt
                                                                                                 
        in december 2007, the company issued 2.75 million 8% convertible notes. these notes are being repaid out of the proceeds of the first tranche of the funding announced on may 14, 2008.the difference between the carrying amount of the liability component at the date of issue and the amount reported in the balance sheet at december 31, 2007 represents the change in amortized cost under the effective interest rate method.
                                                                                                 
        6. current liabilities – provisions
                                                                                                 
        included in provisions is 4,756,000 which relates to the fair value of the contingent consideration payable to former ester shareholders in cash or shares, at amarin’s option, on the achievement of a certain milestone as a result of the acquisition of ester neurosciences limited on december 5, 2007. the achievement of this milestone is considered to be probable and is recognized as a liability.
                                                                                                 
        7. basis of preparation
                                                                                                 
        as at december 31, 2007, the company had cash balances of 18,303,000. as previously announced, on may 14, 2008, amarin announced a private placement of ordinary shares for up to 60 million to be funded in two equal tranches. amarin expects to announce the closing of the first tranche shortly. the investors in this funding have an option to fund up to 30 million in the second tranche upon completion of certain business milestones by the company. amarin now forecasts having sufficient cash to fund operations for at least the next 12 months. the directors of the company believe it is appropriate to prepare the financial statements on a going concern basis. the basis of preparation assumes that the company will continue in operational existence for the foreseeable future.
                                                                                                 
        non-current assets property, plant and equipment
                                                                             595                    
        current assets inventory
                                                                                                 
        non-current liabilities borrowings
                                                                             2,051                    
        equity capital and reserves attributable to equity holders of the company share capital
                                                                             12,942                    
        assets non-current assets
                                                                                                 
        other non-current liabilities
                                                                              19                   
        retained losses
                                                                              -9,612                   
        total equity
                                                                              162                   
        total equity and liabilities
                                                                              396                   
        2. the selected financial data set out in this press release should be read in conjunction with our 2006 20-f which was filed with the sec on march 5, 2007 and our 2006 statutory annual report (including risk factors described therein) which was furnished on a form 6-k to the sec on may 9, 2007 and our ifrs transition document also furnished on a form 6-k to the sec on may 9, 2007.
                                                                                                 
        3. loss per share basic loss per share is calculated by dividing the net income by the weighted-average number of shares in issue in the period. the company reported a net income in the three months ended september 30, 2006 and 2007. as a result the loss per share is not reduced by dilution from outstanding options and warrants.
                                                                                                 
        4. going concern basis as at september 30, 2007, amarin had cash of 20.7 million compared to 36.8 million at december 31, 2006. amarin has no debt other than working capital liabilities and based on current business activities forecasts having sufficient cash to fund the group’s operating activities into september 2008.
                                                                                                 
        amarin intends to obtain additional funding through earning licensing fees from its partnering activities and/or completing further financings. there is no assurance that amarin’s efforts to raise additional funding will be successful. if efforts are unsuccessful, there is uncertainty as to whether amarin will be able to fund its business through the third quarter of 2008 and beyond.
                                                                                                 
        these selected data do not include any adjustments that might be necessary should such funding not be available. amarin believes it will be successful in obtaining further funds as described above and the directors have therefore presented the selected data on a going concern basis.
                                                                                                 
        shareholders’ equity
                                                                                                 
        fair value investment reserve
                                                                                               
        2. the selected financial data set out in this press release should be read in conjunction with our 2006 annual report on form 20-f, which was filed with the sec on march 5, 2007, our 2006 statutory annual report (including risk factors described therein), which was furnished to the sec on form 6-k on may 9, 2007, and our ifrs transition document also furnished to the sec on form 6-k on may 9, 2007. 3. intangible assets on april 24, 2007, amarin announced the results from its phase iii clinical trials of miraxion to treat hd, which showed no statistically significant difference in either study between miraxion and placebo with regard to primary and secondary endpoints. at march 31, 2007, the valuation model for miraxion, which incorporated appropriate industry-based risk factors, continued to show that the fair value of miraxion was in excess of its book value of 9.5 million and, on that basis, no impairment write down is recognised in respect of the intangible asset at march 31, 2007. while miraxion may have potential value in central nervous system disorders and other therapeutic indications, due to the results of the phase iii trials, at this stage, amarin has determined that it is appropriate to write off the intangible asset, all of which relates to miraxion. this is a non-adjusting event for the first quarter. the non-cash write off will occur in the second quarter of 2007 and will increase net income and reduce net assets of amarin by an amount equivalent to the intangible asset’s carrying value at the date of impairment, estimated to be 9.5 million.
                                                                                                 
        derivative liability
                                                                                                 
        total capital and reserves
                                                                                    38,568             
        fixed assets
                                                                                                 
        tangible assets
                                                                                     282 198  421  261   2,305 1,482   
        investments
                                                                                           158,171 158,171   44 10,064 
        stock
                                                                                             6,331 4,799   
        debtors
                                                                                     2,789 2,251  2,135  913 524,601 587,604 3,696 9,694   
        cash at bank and in hand
                                                                                     36,802 28,815  16,382  7,211 149 307 11,232 15,072   
        creditors: amounts falling due within one year
                                                                                     -10,756 -6,852  -3,654     -30,973 41,557   
        net current assets/
                                                                                     28,835     5,225       
        total assets less current liabilities
                                                                                     38,070 33,702  25,249  9,241 5,558  37,338 18,967   
        creditors: amounts falling due after more than one year
                                                                                     -116 -137       -34,311 22,792   
        convertible loan note
                                                                                                 
        provisions for liabilities and charges
                                                                                     -119 -85  -652     -45 31   
        net assets
                                                                                     37,835 33,480  24,597         
        capital and reserves
                                                                                                 
        called up share capital
                                                                                     7,990 7,121  4,471  1,454 4,000,000 4,000,000 29,076 11,838   
        share premium account
                                                                                     146,859 130,654  102,644  70,223 5,000,000 5,000,000 71,015 37,981   
        profit and loss account
                                                                                     -144,430 -131,711  -109,934      -52,648   
        total equity shareholders’ funds
                                                                                     37,835            
        net current assets
                                                                                      24,214  14,863         
        equity shareholders’ funds
                                                                                      33,480  24,597   5,558      
        statement of operations data — uk gaap
                                                                                                 
        net sales revenues
                                                                                       500,000  1,017,000        
        total (loss) from operations
                                                                                       -18,908,000          
        (loss) from continuing operations
                                                                                       -18,908,000          
        net income
                                                                                       -18,707,000  4,012,000        
        net income per ordinary share
                                                                                       -400  210        
        amounts in accordance with us gaap
                                                                                                 
        operating
                                                                                       -19,527,000          
        net
                                                                                       -19,630,000          
        weighted-average shares
                                                                                       46,590,000  22,511,000        
        consolidated balance sheet data
                                                                                                 
        amounts in accordance with uk gaap
                                                                                                 
        working capital (liabilities)/assets
                                                                                       28,673,000          
        long term obligations
                                                                                       -180,000          
        capital stock
                                                                                       6,778,000  3,206,000        
        total shareholders’ equity/
                                                                                       38,580,000  16,693,000        
        number of ordinary shares in issue
                                                                                       77,549,000  37,632,000        
        denomination of each ordinary share
                                                                                                 
        number of £ 13% cumulative preference shares in issue
                                                                                                 
        long term obligations/deferred credit
                                                                                       -41,519,000          
        statement of operations data – uk gaap
                                                                                                 
        total income from operations
                                                                                                 
        working capital assets/
                                                                                         8,651,000        
        number of £1 3% cumulative preference shares in issue
                                                                                                 
        net assets/
                                                                                          4,241   2,982    
        equity shareholders’ funds/
                                                                                          4,241       
        tangible fixed assets
                                                                                                 
        fixture and fittings
                                                                                           129,537 117,629     
        office equipment
                                                                                           12,203 5,091     
        creditors: amounts due within one year
                                                                                                 
        net current(liabilities)/assets
                                                                                                 
        net current liabilities
                                                                                             -9,714    
        equity shareholders’ (deficit)/funds
                                                                                                 
        unaudited
                                                                                                 
        merger reserve
                                                                                             -1,653 -1,027   
        profit and loss account — deficit
                                                                                             -95,456    
        total shareholders’ funds/
                                                                                             2,982    
        analysis of shareholders’ funds/
                                                                                                 
        non-equity
                                                                                              6,206   
        net current (liabilities)/assets
                                                                                              -11,992   
        net (liabilities)/assets
                                                                                              -3,856   
        total shareholders’ (deficit)/funds
                                                                                              -3,856   
        analysis of shareholders’ (deficit)/funds
                                                                                                 
        a s s e t s
                                                                                                 
        accounts receivable from related parties
                                                                                                50 
        inventories
                                                                                               2,438 1,878 
        prepaid expenses
                                                                                               448 227 
        intangibles
                                                                                               32,378 15,119 
        l i a b i l i t i e s
                                                                                                 
        short-term debt
                                                                                               118  
        short-term debt owed to related parties
                                                                                               30,919  
        current portion of finance leases and purchase contracts
                                                                                               97 166 
        other current liabilities
                                                                                               3,693 1,645 
        long-term debt owed to related parties
                                                                                               4,466 5,847 
        finance leases and purchase contracts
                                                                                                94 
        provision for deferred taxes
                                                                                                 
        other long term creditors
                                                                                               77 151 
        provision for restructuring
                                                                                               669  
        s h a r e h o l d e r s ’ e q u i t y
                                                                                                 
        ordinary shares of 10 pence par value 500,000,000 shares authorized, 76,743,893 (us11,169,000) issued and outstanding at december 31, 2001; 500,000,000 shares authorized, 68,145,760 (us10,180,000) issued and outstanding at december 31, 2000; and 500,000,000 authorized, 19,014,462 (us3,064,000) issued and outstanding at december 31, 1999
                                                                                               7,674 6,814 
        3% cumulative convertible preference shares of 100 pence par value 5,000,000 shares authorized, 4,129,819 (us6,011,000) issued and outstanding at december 31, 2001; 5,000,000 shares authorized, 4,129,819 (us6,304,000) issued and outstanding at december 31, 2000; and 5,000,000 authorized, 4,129,819 (us6,656,000 issued and outstanding at december 31, 1999
                                                                                               4,130 4,130 
        additional paid-in capital.
                                                                                               38,144 36,062 
        merger and other reserves
                                                                                               -1,027 -1,027 
        total liabilities and shareholders’ equity
                                                                                               62,486 32,502 
        benefit from deferred taxes
                                                                                                 
        benefit from restructuring
                                                                                                2,108 
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 
                                                                    
          cash flows from operating activities:
                                                                    
          net loss
        -44,609,000 -7,738,000 -14,139,000 -15,697,000 -48,618,000 -25,134,000 1,522,000 -9,953,000  -19,311,000 -17,560,000 -16,460,000        -1,626,000 4,926,000 -6,788,000 4,415,000 -20,553,000 7,068,000 -3,462,000 -1,820,000 -24,431,000 -33,669,000 -24,471,000 -34,210,000 -24,095,000      -15,772,000        -26,050,000 15,323,000 -25,980,000 -15,411,000 -48,884,000 -39,774,000 -62,158,000 -10,567,000 -26,428,000   18,338,000 96,345,000   
          adjustments to reconcile net loss to net cash from operating activities:
                                                                    
          depreciation and amortization
        95,000 1,000 1,000 1,000 8,000 25,000 32,000 33,000 33,000 33,000 31,000 63,000 125,000 138,000 144,000 144,000 144,000 144,000 149,000 150,000 151,000 150,000 150,000 146,000 127,000 47,000 6,000 11,000 1,000 3,000 8,000 11,000 13,000 17,000 21,000    44,000 41,000 40,000 43,000 42,000 43,000 48,000 51,000 56,000 67,000 60,000 60,000 59,000 57,000 48,000 43,000 32,000 28,000 16,000 17,000 15,000 
          accretion of investments
        -2,710,000 -830,000 -973,000 -1,216,000  -1,418,000 -1,198,000 -1,547,000                -151,000                                     
          stock-based compensation
        5,383,000 1,956,000 6,039,000 4,327,000 3,402,000 4,698,000 4,387,000 5,218,000 4,647,000 3,608,000 1,835,000 5,556,000 6,612,000 4,877,000 8,646,000 6,078,000 10,102,000 10,432,000 2,479,000 13,925,000 11,508,000 11,583,000 12,131,000 10,591,000 8,188,000 7,963,000 7,883,000 6,883,000 4,774,000 6,651,000 3,619,000 3,762,000 3,489,000 3,495,000 3,625,000 3,351,000 3,237,000 3,414,000 3,365,000 3,597,000 3,712,000 3,919,000 3,216,000 3,042,000 2,750,000 1,921,000 2,394,000 1,957,000 515,000 4,207,000 5,089,000 4,874,000 4,731,000 4,635,000 4,835,000 3,874,000 3,272,000 2,662,000 1,820,000 1,540,000 
          amortization of intangible asset
        592,000 866,000 728,000 729,000 729,000 728,000 729,000 729,000 701,000 701,000 701,000 702,000 636,000 636,000 637,000 636,000 637,000 636,000 636,000 361,000 360,000 361,000 360,000 360,000 195,000 161,000 162,000 161,000 162,000 161,000 161,000 162,000 161,000 162,000 161,000 162,000 161,000 162,000 161,000 161,000 162,000 161,000 162,000 161,000 162,000 161,000 162,000 161,000 161,000 162,000 162,000 161,000         
          changes in assets and liabilities:
                                                                    
          accounts receivable
        16,314,000 -8,179,000 -12,396,000 15,545,000 -9,637,000 11,049,000 -7,885,000 17,757,000 -11,163,000 330,000 10,506,000 -2,246,000 -7,611,000 20,563,000 -33,708,000 53,419,000 -14,292,000 32,898,000 -30,984,000 3,299,000 -7,282,000 -22,307,000 33,303,000 -41,858,000 -12,847,000 -8,185,000 -15,913,000 -12,962,000 -18,875,000 2,661,000 -11,129,000 6,138,000 -10,708,000 2,865,000 -8,025,000 -9,465,000 -2,493,000 135,000 -2,620,000 -1,193,000 -2,587,000 -1,296,000 -1,398,000 -703,000 -1,175,000 -303,000 -2,339,000 -380,000 76,000 -1,454,000 1,174,000 -3,441,000         
          inventory
        68,464,000 17,021,000 6,064,000 13,894,000 67,235,000 12,679,000 18,803,000 6,726,000 10,022,000 3,086,000 20,204,000 22,809,000 23,218,000 20,454,000 -27,154,000 -52,940,000 -46,662,000 -36,813,000 -41,563,000 -42,028,000 -40,333,000 -23,687,000 -32,723,000 -15,352,000 -22,212,000 -8,289,000 11,641,000 -107,000 -14,129,000 -3,580,000 -4,989,000 -4,844,000 -1,710,000 -3,736,000 -935,000 -3,372,000             392,000 1,431,000   -12,273,000        
          prepaid and other current assets
        16,326,000 -12,021,000 7,338,000 -12,577,000 -5,405,000 24,405,000 -23,410,000 3,476,000 7,846,000 23,842,000 -23,428,000 -386,000 8,566,000 4,201,000 -4,167,000 -5,740,000 -1,006,000 7,080,000 1,270,000 1,251,000 -4,613,000 -2,750,000 -2,857,000 -7,416,000 -452,000 -5,756,000 -1,769,000 -2,389,000 -10,000 -57,000 740,000 -163,000 730,000 391,000 2,709,000 2,198,000 -1,242,000 -265,000 629,000 -2,953,000 1,537,000 -3,381,000 985,000 340,000                 
          other long-term assets
        43,000 26,000 39,000 39,000 37,000 37,000 37,000 36,000 35,000 209,000 34,000 -556,000     -24,000     28,000 -459,000 -469,000     -1,000 479,000 89,000                         
          interest receivable
        -519,000 29,000 -30,000 450,000 180,000 -249,000   44,000 100,000 120,000 -16,000 -142,000 254,000 89,000 140,000 15,000 51,000 554,000 118,000 403,000 -420,000 -291,000 -1,021,000                                     
          deferred revenue
            -4,449,000 -401,000 -124,000 -382,000 -9,545,000 -445,000 -351,000 -311,000 -329,000 -372,000 -423,000 -336,000 -502,000 -662,000 -273,000 -1,308,000 -1,594,000 961,000 1,267,000 -158,000 -426,000 -547,000 -246,000 2,150,000 -106,000 -142,000 -383,000 1,940,000 -43,000 -293,000 -293,000 -293,000 -293,000 1,763,000 -230,000 -164,000 14,625,000 -1,703,000             
          accounts payable, accrued expenses and other current liabilities
                                                                    
          other long-term liabilities
        2,272,000 -115,000 397,000 -413,000 1,930,000 -192,000 182,000 221,000 1,758,000 84,000 -1,612,000 115,000 -2,014,000 1,948,000 12,000 635,000 2,248,000 -222,000 -177,000 -596,000 1,902,000 -432,000 2,192,000 -1,033,000 -1,518,000 -1,136,000 -817,000 -2,369,000 1,871,000 1,888,000   -8,000 -9,000 457,000                         
          net cash from operating activities
        -22,470,000 -12,697,000 16,606,000 -12,459,000 -13,310,000 -2,360,000 -2,749,000 -12,601,000 -645,000 7,329,000 7,204,000 -7,008,000 1,552,000 -18,213,000 -64,584,000 -98,847,000 -28,240,000 -4,540,000 -15,053,000 -18,704,000 -38,323,000 10,853,000 1,587,000 4,137,000 -8,936,000 21,750,000 15,909,000 -38,089,000 -32,303,000 -28,157,000 -24,438,000 -9,805,000 -2,140,000 -6,277,000 -10,503,000 -13,917,000 -19,311,000 -18,724,000 -8,969,000 -24,811,000 -24,648,000 -22,481,000 -24,976,000 -12,643,000 -13,624,000 -19,878,000 -11,313,000 -27,494,000 -33,081,000 -44,839,000 -52,781,000 -59,635,000 -43,764,000 -39,417,000 -21,385,000 -17,737,000 -11,576,000 -8,277,000 -10,777,000 -8,809,000 
          capital expenditures
         -1,000 -251,000 -364,000 -5,000  -12,000 -18,000  -14,000 -72,000 -213,000 -172,000 -92,000 -365,000  
          free cash flows
        -22,470,000 -12,697,000 16,606,000 -12,459,000 -13,310,000 -2,360,000 -2,749,000 -12,601,000 -645,000 7,329,000 7,204,000 -7,008,000 1,552,000 -18,213,000 -64,584,000 -98,847,000 -28,240,000 -4,540,000 -15,053,000  -38,323,000 10,852,000 1,587,000 3,886,000 -9,300,000 21,750,000 15,909,000 -38,089,000 -32,308,000 -28,157,000 -24,438,000  -2,140,000 -6,277,000 -10,503,000 -13,929,000 -19,311,000 -18,724,000 -8,969,000 -24,811,000 -24,666,000 -22,481,000 -24,976,000 -12,643,000 -13,624,000 -19,878,000 -11,313,000  -33,081,000 -44,839,000 -52,781,000 -59,649,000 -43,836,000 -39,630,000 -21,557,000 -17,829,000 -11,941,000 -8,277,000 -10,777,000  
          cash flows from investing activities:
                                                                    
          maturities of securities
        70,500,000 57,000,000 50,300,000 55,000,000 47,000,000 52,800,000 71,000,000 62,000,000 29,111,000 64,004,000 64,080,000 32,913,000  54,203,000 73,191,000 113,220,000                                             
          purchases of securities
        -128,821,000 -69,129,000 -37,890,000 -42,936,000 -69,839,000 -109,351,000 -66,305,000 -33,281,000 -99,601,000 -33,236,000 -29,737,000 -52,523,000 -44,126,000 -23,335,000 -1,000 -14,171,000 -57,128,000 -158,557,000   -91,589,000 -59,632,000                                       
          investment in software and website development costs
                                                                    
          purchases of furniture, fixtures and equipment
                            -1,000 -251,000 -364,000                                    
          net cash from investing activities
        -58,321,000 -12,129,000 12,410,000 12,064,000 -22,839,000 -56,551,000 4,695,000 28,719,000 -70,999,000 30,767,000 34,320,000 -19,610,000 -27,819,000 30,868,000 73,190,000 99,049,000 25,016,000 -99,491,000 50,649,000 127,929,000 23,686,000 -4,359,000 -102,468,000 -293,822,000 -364,000 -1,313,000   -5,000    -12,000 -21,000 -18,000        -14,000 -12,627,000 -626,000 -997,000 -92,000 -365,000    
          cash flows from financing activities:
                                                                    
          proceeds from issuance of ordinary shares under employee stock purchase plan
                                                                    
          proceeds from exercise of stock options
            10,000                                                     
          taxes related to stock-based awards
                                                                    
          net cash from financing activities
        587,000 -248,000 -663,000 -1,119,000 17,000 -68,000 34,000 -1,426,000 83,000 -277,000 60,000 364,000 38,000 -156,000 244,000 -505,000 -196,000 -110,000 426,000 -5,193,000 -5,606,000 -13,292,000 -14,154,000 -25,855,000 -19,316,000 433,400,000 -4,425,000 -47,000 200,543,000 7,845,000 -2,354,000 65,217,000 -3,309,000 -101,000 -109,000 11,754,000 63,795,000 97,000 -766,000 12,651,000 5,417,000 -169,000 54,299,000 -2,272,000 4,785,000 -2,437,000 258,000 -1,290,000 121,298,000 427,000 1,187,000 101,523,000 4,898,000 26,815,000 147,049,000 2,688,000 4,360,000 12,750,000 106,849,000 
          net increase in cash and cash equivalents and restricted cash
        -80,204,000 -25,074,000 28,353,000 -1,514,000  -58,979,000 1,980,000 14,692,000 -71,561,000 37,819,000   -26,229,000 12,499,000 8,850,000 -303,000 -3,420,000 -104,141,000 36,022,000 104,032,000 -20,243,000    -28,616,000 453,837,000 10,683,000 -38,136,000 168,235,000 -20,365,000 -26,792,000 55,412,000                             
          cash and cash equivalents and restricted cash, beginning of period
        78,439,000 121,338,000 199,777,000 218,189,000 223,372,000 190,879,000 648,495,000 250,727,000 74,237,000                             
          cash and cash equivalents and restricted cash, end of period
        -1,765,000 -25,074,000 28,353,000 119,824,000 -36,132,000 -58,979,000 1,980,000 214,469,000 -71,561,000 37,819,000 41,584,000 191,935,000 -26,229,000 12,499,000 8,850,000 223,069,000 -3,420,000 -104,141,000 36,022,000 294,911,000 -20,243,000 -6,798,000 -115,035,000 332,955,000 -28,616,000 453,837,000 10,683,000 212,591,000 168,235,000 -20,365,000 -26,792,000 129,649,000                             
          supplemental disclosure of cash flow information:
                                                                    
          cash paid during the year for:
                                                                    
          income taxes, net of refunds
                                                                    
          supplemental disclosure of non-cash transactions:
                                                                    
          initial recognition of operating lease right-of-use asset
        213,000 -981,000 1,837,000 1,000 879,000 108,000 81,000 177,000 -150,000 134,000 446,000 893,000 96,000 16,000 1,036,000         8,995,000                                 
          initial recognition of furniture, fixtures and equipment lease
                624,000                                                 
          adjustments to reconcile loss to net cash from operating activities:
                                                                    
          accounts payable and other current liabilities
         -3,713,000 23,538,000 -17,541,000  -28,988,000 8,502,000 -34,896,000  -4,241,000 26,864,000 -15,237,000  -66,015,000 61,001,000 -69,658,000  -5,697,000 44,800,000 6,479,000  55,710,000 -13,755,000 79,285,000 10,951,000 40,197,000 17,003,000 -2,238,000 1,597,000 11,859,000 15,023,000 9,123,000 16,597,000 1,961,000 6,129,000 15,580,000 -1,444,000 -624,000 6,242,000 4,531,000 -4,413,000 7,926,000 4,427,000 2,549,000 3,355,000 2,677,000               
          proceeds from issuance of common stock under employee stock purchase plan
                                   620,000                               
          taxes paid related to stock-based awards
         -248,000 -720,000 -1,119,000  -68,000 -88,000 -1,436,000  -279,000 -187,000 -1,507,000  -166,000 -158,000 -535,000  -591,000 -677,000 -7,252,000  -476,000 -521,000 -13,831,000  -1,040,000 -9,080,000 -546,000 -2,958,000 -127,000 -2,553,000 -174,000 -156,000 -209,000 -2,228,000 -148,000 -153,000                       
          income taxes
         -1,000 -169,000 22,000 -1,937,000 -1,376,000 -698,000 29,000 -1,264,000 -432,000 -633,000 -38,000 -292,000 622,000 -2,163,000 51,000 -14,000 -41,000 3,706,000 5,000 10,000 177,000   -20,000 16,000   25,000 20,000 782,000 23,000 567,000 408,000 714,000 64,000 364,000 326,000 500,000 267,000 185,000 355,000 154,000 17,000 200,000 167,000 381,000 33,000 630,000 202,000 563,000 421,000 384,000 202,000 111,000 180,000 171,000 145,000 265,000 
          amortization of investments
                -1,113,000 -730,000 -946,000 -907,000 -284,000 182,000 201,000 374,000 365,000 438,000 477,000 649,000 831,000 738,000                                       
          net decrease in cash and cash equivalents and restricted cash
                   -26,254,000           -115,035,000 -315,540,000                                     
          shares issued in settlement of laxdale milestone payment
                                                                    
          purchase of furniture, fixtures and equipment
                 -1,000                                                   
          proceeds from the sale of common stock
                                                                   
          net income
                      -69,956,000 -31,563,000 14,698,000 -13,151,000                -10,825,000 -13,634,000 -20,941,000    -29,771,000   -31,512,000 -31,126,000            -88,285,000    18,294,000 
          adjustments to reconcile net income to net cash from operating activities:
                                                                    
          (purchases) disposal of furniture, fixtures and equipment
                                                                    
          cash received during the year for:
                                                                    
          laxdale milestone
                        12,000,000                                         
          proceeds from the sale of common stock, net of transaction costs
                                                                   
          proceeds from exercise of stock options, net of transaction costs
                 2,000 7,000 1,871,000 1,000 10,000 19,000 30,000 306,000 481,000 75,000 2,059,000 3,297,000 203,000 352,000 1,306,000 4,934,000 2,200,000 1,888,000 15,456,000 9,908,000 14,668,000 278,000 1,548,000 187,000 55,000 100,000 296,000 151,000 12,000 102,000 22,000 27,000 4,000 23,000 -1,000 285,000 86,000 102,000 439,000 371,000 1,156,000 5,887,000 791,000 21,000 119,000 3,230,000 1,724,000 
          amortization of debt discount and debt issuance costs
                            34,000 111,000 201,000 289,000 362,000 404,000 432,000 446,000 496,000 547,000 567,000 573,000 596,000 589,000 584,000 563,000 537,000 2,208,000 2,565,000 2,473,000 2,604,000 1,966,000 1,877,000 1,811,000 1,824,000 1,772,000 1,094,000 1,173,000 4,399,000 4,492,000 4,536,000 4,204,000 3,491,000 3,345,000       
          accrued interest payable
                            -80,000 -108,000 -129,000 -111,000 -65,000 -64,000 -8,000 -73,000 61,000 -313,000 269,000 -327,000 468,000 -3,131,000 -1,561,000 -2,267,000 -1,475,000 -3,314,000 599,000 -2,015,000 747,000 -1,410,000 1,303,000 -1,292,000   2,101,000 -405,000 2,073,000 1,346,000 4,911,000 2,124,000 1,426,000 -1,414,000 1,312,000 1,196,000     
          sale and maturities of securities
                        82,144,000 59,066,000 125,159,000 127,925,000 115,275,000 55,274,000                                       
          investment in website development costs
                                                                    
          disposal (purchases) of furniture, fixtures and equipment
                                                                    
          payment of transaction costs for conversion of preferred stock
                            -238,000 -28,000                                      
          payment on debt from royalty-bearing instrument
                            -9,420,000 -12,991,000 -14,595,000 -13,330,000                                     
          interest
                            161,000 689,000 318,000 875,000 1,014,000 -11,405,000 7,273,000 7,709,000 5,497,000 5,779,000 4,378,000 5,873,000 4,705,000 4,990,000 3,435,000 4,111,000 3,244,000 6,171,000 2,530,000 5,138,000 2,334,000 4,396,000 1,556,000 4,273,000 1,411,000 3,890,000 1,096,000 3,636,000 840,000 2,625,000 2,625,000        
          conversion of series a convertible preferred stock into common stock
                                                                  
          disposal of furniture, fixtures and equipment
                           4,000                                         
          proceeds from the issuance of common stock, net of transaction costs
                                                                    
          adjustments to reconcile income to net cash from operating activities:
                                                                    
          cash (paid) received during the year for:
                                                                    
          proceeds from issuance of common stock, net of transaction costs
                              -837,000 440,108,000   194,833,000 70,007,000     -1,000                   -17,000 98,671,000 
          cash received (paid) during the year for:
                                                                    
          disposal (purchase) of furniture, fixtures and equipment
                                                                   
          transaction costs related to exchange of exchangeable senior notes
                                            -2,000                        
          exchange of exchangeable senior notes into common stock
                                                                   
          proceeds from sales of securities
                               17,077,000                                     
          purchase of securities
                               -310,648,000                                     
          deferred income taxes
                                            11,932,000 -1,288,000 -1,400,000 -446,000 -2,670,000 -851,000 -636,000 -95,000 -3,696,000 75,000 31,000 -24,000 2,955,000 -1,553,000 -887,000 -3,949,000         
          proceeds from issuance of exchangeable debt
                                                                  
          payment of debt issuance costs
                                        -1,207,000                         
          repurchase of exchangeable senior notes, including transaction costs
                                                                    
          payment on long-term debt from royalty-bearing instrument
                                -10,211,000 -8,908,000 -6,110,000 -6,423,000 -4,151,000 -3,826,000 -2,928,000 -3,785,000                             
          other receivables
                                                                    
          purchases of equipment
                                    -5,000    -12,000     -18,000        -14,000 -72,000 -213,000 -172,000 -92,000 -365,000    
          loss on sale of fixed assets
                                             48,000                     
          allowance for doubtful accounts
                                                                    
          gain on change in fair value of derivative liabilities
                                               1,250,000                     
          repurchase of exchangeable senior notes
                                         -15,107,000                         
          stock-based compensation—warrants
                                                -9,000 -326,000 -105,000 -72,000 -2,524,000 276,000 -1,004,000 -451,000 -2,790,000 -1,195,000 1,858,000 2,374,000 -1,100,000 -3,352,000 5,035,000 -679,000 
          gain on extinguishment of debt
                                                                  
          proceeds from issuance of preferred stock, net of transaction costs
                                                5,517,000 -104,000 52,253,000                 
          proceeds from issuance of convertible debt, net of transaction costs
                                                                    
          proceeds from exercise of warrants, net of transaction costs
                                                2,713,000    40,000 50,000 70,000 194,000 1,596,000 14,871,000 59,000 41,000 3,731,000 8,476,000 6,454,000 
          debt issuance costs
                                                    -55,000               
          payment under capital leases
                                                                    
          net decrease in cash and cash equivalents
                                          -10,612,000 -2,175,000     -12,015,000     -15,093,000 -13,750,000 -27,236,000             
          cash and cash equivalents, beginning of period
                                        98,251,000 106,961,000 119,539,000 191,514,000 260,242,000 116,602,000 31,442,000 
          cash and cash equivalents, end of period
                                        -5,449,000 -6,378,000 -10,612,000 96,076,000 -19,311,000 45,071,000 -8,872,000 81,363,000 -12,015,000 -17,074,000 -25,145,000 161,195,000 -15,896,000 -15,093,000 -13,750,000 164,278,000 -34,371,000 76,459,000 -52,354,000 201,780,000 45,132,000 -35,145,000 4,433,000 245,822,000 -9,253,000 -5,591,000 1,964,000 129,482,000 
          transfer of preferred stock purchase option derivative liability to equity
                                                868,000                 
          accretion of preferred stock beneficial conversion features
                                                                   
          reacquisition of conversion option in convertible notes
                                                                   
          net increase in cash and cash equivalents
                                             45,071,000 -8,872,000 -25,598,000   -25,145,000 41,656,000     -34,371,000 76,459,000 -52,354,000 -58,462,000 45,132,000 -35,145,000 4,433,000 129,220,000 -9,253,000 -5,591,000 1,964,000 98,040,000 
          loss on change in fair value of derivative liabilities
                                             -3,610,000            1,402,000           
          proceeds from issuance of convertible debt
                                           30,000,000                         
          loss on sale of property, plant and equipment
                                                                    
          (gain) loss on change in fair value of derivative liabilities
                                                                    
          refund of equity issuance costs
                                                                   
          payments under capital leases
                                                -3,000 -2,000 28,000 -25,000 -13,000 -26,000      -19,000 -1,000     
          supplemental disclosure of non-cash items:
                                                                    
          depreciation
                                             35,000                       
          inventories
                                             533,000 1,038,000 -2,359,000 719,000 795,000 -4,316,000 -2,450,000 -1,847,000 5,257,000 4,687,000 4,861,000    -6,173,000         
          other non-current assets
                                                -98,000 211,000 189,000 129,000 1,997,000 295,000 383,000 1,339,000 975,000 -1,000 -383,000 16,295,000 -11,822,000 -3,483,000 -2,050,000     
          other non-current liabilities
                                             463,000 -32,000 -35,000 -273,000 -18,000 -5,000 245,000            2,793,000     
          purchase of equipment
                                             -21,000                     
          non-cash transactions:
                                                                    
          accretion of preferred stock beneficial conversion feature
                                                                    
          excess tax provision on stock-based awards
                                               94,000   89,000 552,000                 
          acquisition of treasury stock
                                               -694,000 -43,000 -34,000 -117,000                 
          gain on changes in fair value of derivative liabilities
                                                  600,000 -464,000  -4,466,000 -3,011,000 -4,393,000             
          change in lease liability
                                                        3,000 22,000 -12,000 -7,000 5,000 -9,000 -38,000 -8,000 18,000 11,000 -38,000 -12,000 
          shares issued for services
                                                        9,000 10,000 8,000 8,000 10,000 8,000 6,000    6,000 
          restricted cash
                                                    400,000 400,000 -1,400,000         
          repurchase of convertible notes, including transaction costs
                                                                    
          excess tax benefit from (provision on) stock-based awards
                                                                    
          reclassification of warrant liability to additional paid-in capital
                                                                    
          excess tax provision on (benefit from) stock-based awards
                                                                    
          loss on changes in fair value of derivative liabilities
                                                           -3,620,000         
          excess tax (provision on) benefit from stock-based awards
                                                 -66,000                   
          excess provision on stock-based awards
                                                   -552,000                 
          excess tax benefit from stock-based awards
                                                    2,300,000 -1,000 605,000 37,000 -325,000 -678,000 -1,228,000 -2,146,000 -6,076,000 -1,884,000 -2,628,000 -510,000   
          foreign exchange loss on intangible asset
                                                                    
          (gain) loss on changes in fair value of derivative liabilities
                                                                    
          other current and prepaid assets
                                                                    
          purchase of long-term investment
                                                                    
          purchase of intangible asset
                                                                    
          proceeds on issuance of exchangeable senior notes, net of transaction costs
                                                                    
          proceeds from long-term debt, net of transaction costs
                                                                    
          reclass of warrant liability to additional paid-in capital
                                                                    
          current portion of long-term debt
                                                                    
          other current assets
                                                     -59,000 68,000 -1,380,000 1,973,000 -1,365,000 4,880,000 -3,798,000 857,000 2,323,000 -1,465,000 -3,131,000    586,000 
          supplemental disclosure of non-cash items: reacquisition of conversion option in convertible notes
                                                                    
          excess tax provision from stock-based awards
                                                       1,000             
          accounts payable and other liabilities
                                                       -3,105,000   -11,680,000 14,993,000  18,570,000 13,368,000 1,137,000    -3,217,000 
          proceeds from long term debt, net of transaction costs
                                                                    
          repayment of capital leases
                                                                    
          accounts payable, accrued expenses and other liabilities
                                                                    
          proceeds from issuance of exchangeable debt, net of transaction costs
                                                             144,316,000     
          transfer from derivative liability to equity, fair value of warrants exercised
                                                             11,603,000 91,961,000 321,000  21,000,000 79,229,000 29,229,000 
          proceeds from issuance of senior notes, net of transaction costs
                                                                    
          reclass of derivative warrant liability to additional paid-in capital
                                                                    
          purchase of long term investment
                                                            -412,000 -413,000      
          laxdale intangible asset
                                                                    
          expense for commitment fee
                                                                    
          amortization of laxdale milestone
                                                                    
          loss on change in fair value of derivative liability
                                                             -16,453,000 18,930,000 66,209,000     
          gain on sale of intellectual property
                                                                    
          stock-based compensation—ester
                                                                    
          non-cash interest
                                                                    
          loss on changes in fair value of derivative liability
                                                                -30,734,000 -106,614,000 185,359,000 -25,342,000 
          sale of lorazepam
                                                                    
          proceeds on issuance of convertible debt
                                                                    
          repayment of convertible debt
                                                                    
          repayment of finance leases
                                                                    
          reclass of additional paid-in capital to warrant liability
                                                                    
          conversion of bridge loans
                                                                    
          issuance of ester shares
                                                                    
          issuance of proseed shares
                                                                    
          stock issued for services
                                                                 13,000   
          other assets
                                                                 -1,083,000   
          accounts payable, accrued expenses, and other liabilities
                                                                 3,235,000   
          cash flows from operating activities
                                                                    
          loss after tax
                                                                    
          adjustments:
                                                                    
          depreciation of property, plant and equipment
                                                                    
          amortization of intangible assets
                                                                    
          impairment of intangible assets
                                                                    
          (increase)/decrease fair value of available for sale investment
                                                                    
          share based payments
                                                                    
          share based payments — warrants
                                                                    
          effect of exchange rate changes on assets/liabilities and other items
                                                                    
          interest received
                                                                    
          interest expense
                                                                    
          interest on finance leases
                                                                    
          increase in other liabilities
                                                                    
          decrease/(increase) in other current assets
                                                                    
          decrease in current liabilities
                                                                    
          (decrease)/increase in provisions
                                                                    
          fair value (gain)/loss on derivative financial liability through income statement
                                                                    
          r&d tax credit
                                                                    
          cash expended on operating activities
                                                                    
          tax refund
                                                                    
          net cash outflow from operating activities
                                                                    
          cash flows from investing activities
                                                                    
          purchase intangible assets
                                                                    
          sale of lorazapam
                                                                    
          purchases of property, plant and equipment
                                                                    
          net cash inflow/(outflow) from investing activities
                                                                    
          cash flows from financing activities
                                                                    
          proceeds from issue of share capital
                                                                    
          net proceeds on the issue of convertible debentures
                                                                    
          interest paid
                                                                    
          expenses on issue of share capital
                                                                    
          expenses on issue of convertible debentures
                                                                    
          repayment of finance lease
                                                                    
          net cash inflow from financing activities
                                                                    
          net increase/(decrease) in cash and cash equivalents
                                                                    
          cash and cash equivalents at the beginning of the year
                                                                    
          exchange rate gains on cash and cash equivalents
                                                                    
          cash and cash equivalents at end of year
                                                                    
          amortization of convertible bridge loan
                                                                    
          share based compensation
                                                                    
          interest paid on finance leases
                                                                    
          decrease in other current assets
                                                                    
          decrease in provisions
                                                                    
          fair value loss /(gain) on derivative financial liability through income statement
                                                                    
          purchase of property, plant and equipment
                                                                    
          net cash (outflow)/inflow from investing activities
                                                                    
          borrowings received
                                                                    
          net (decrease)/increase in cash and cash equivalents
                                                                    
          cash and cash equivalents at beginning of period
                                                                    
          effect of exchange rate changes on cash and cash equivalents
                                                                    
          cash and cash equivalents at end of period
                                                                    
          finance income on option
                                                                    
          (decrease)/increase in other liabilities
                                                                    
          fair value gain on derivative financial liability through income statement
                                                                    
          net cash inflow from investing activities
                                                                    
          impairment of property, plant and equipment
                                                                    
          effect of exchange rate changes on assets/liabilities and other items*
                                                                    
          (increase)/decrease in other current assets
                                                                    
          increase/(decrease) in other liabilities
                                                                    
          effect of exchange rates on foreign currency cash balances
                                                                    
          cash and cash equivalents at the end of the year
                                                                    
          options granted at the market price risk free interest rate
                                                                    
          expected life
                                                                    
          volatility
                                                                    
          expected forfeiture rate
                                                                    
          forced exercise rate
                                                                    
          minimum gain for voluntary exercise rate
                                                                    
          voluntary early exercise at a minimum gain rate
                                                                    
          expected dividend
                                                                    
          net (loss) as reported
                                                                    
          basic and diluted (loss) per ordinary share
                                                                    
          net cash (used) by operating activities
                                                                    
          net cash provided/(used) by financing activities
                                                                    
          net cash (used)/provided by investing activities
                                                                    
          net effect of foreign exchange on cash and cash equivalents
                                                                    
          deduct: stock-based employee compensation expense determined under fair value based method for all awards, net of related tax effect
                                                                    
          add back total stock based compensation expense determined under the intrinsic value based method
                                                                    
          pro forma net
                                                                    
          net cash used by operating activities
                                                                    
          net cash (used)/provided by financing activities
                                                                    
          net cash provided/(used) by investing activities
                                                                    
          cash at beginning of period
                                                                    
          cash outflow on investing activities
                                                                    
          cash inflow from financing activities
                                                                    
          movement in cash and cash equivalents
                                                                    
          cash and cash equivalents at beginning of year
                                                                    
          cash and cash equivalents at the end of year
                                                                    
          net cash (outflow)/inflow from operating activities
                                                                    
          cash and cash equivalents at the beginning of the period
                                                                    
          cash and cash equivalents at the end of the period
                                                                    
          proforma net
                                                                    
          net cash used by investing activities
                                                                    
          net provided by operating activities
                                                                    
          basic and diluted (loss) per ordinary share as reported
                                                                    
          proforma
                                                                    
          weighted-average grant date fair value options granted at the market price
                                                                    
          options granted at a premium to the market price
                                                                    
          options granted at a discount to the market price
                                                                    
          operating profit including discontinued activities
                                                                    
          adjustments to reconcile operating loss to net cash from operating activities:
                                                                    
          depreciation of tangible fixed assets
                                                                    
          amortisation of intangible fixed assets
                                                                    
          changes in assets and liabilities
                                                                    
          prepaid expenses and accrued income
                                                                    
          accounts payable
                                                                    
          other current liabilities
                                                                    
          exchange differences
                                                                    
          total adjustments
                                                                    
          returns on investments and payment for interest
                                                                    
          interest on finance leases and purchase contracts
                                                                    
          net cash from returns on investments and payment for interest
                                                                    
          taxation
                                                                    
          taxation received
                                                                    
          purchase of intangible fixed assets from related party
                                                                    
          purchase of intangible fixed assets
                                                                    
          cash eliminated on sale of south american transdermal business
                                                                    
          sale of property, plant and equipment
                                                                    
          proceeds on sale of uk transdermal business to related party
                                                                    
          cash flows from management of liquid resources
                                                                    
          proceeds on sale of current asset investments
                                                                    
          increase in short term deposits with banks
                                                                    
          net cash from management of liquid resources
                                                                    
          issuance of ordinary shares
                                                                    
          expenses on issuance of ordinary shares
                                                                    
          restructuring costs paid
                                                                    
          (repayment)/proceeds of bank loans
                                                                    
          payments under lease and purchase contracts
                                                                    
          new bank and other loans
                                                                    
          borrowings under short term loan arrangements
                                                                    
          net increase in cash
                                                                    
          cash at beginning of year
                                                                    
          cash at end of year