Alnylam Pharmaceuticals Stock Income Statements

Alnylam Pharmaceuticals Quarterly Income Statements Chart

Quarterly

Annual

Revenue

Gross Profit

Operating Profit

Net Income

Alnylam Pharmaceuticals Quarterly Income Statements Table

Quarterly

Annual

Unit: USD	2025-06-30	2025-03-31	2024-12-31	2024-09-30	2024-06-30	2024-03-31	2023-12-31	2023-09-30	2023-06-30	2023-03-31	2022-12-31	2022-09-30	2022-06-30	2022-03-31	2021-12-31	2021-09-30	2021-06-30	2021-03-31	2020-12-31	2020-09-30	2020-06-30	2020-03-31	2019-12-31	2019-09-30	2019-06-30	2019-03-31	2018-12-31	2018-09-30	2018-06-30	2018-03-31	2017-12-31	2017-09-30	2017-06-30	2017-03-31	2016-12-31	2015-12-31	2014-12-31	2013-12-31	2012-12-31	2011-12-31	2011-09-30	2011-06-30	2011-03-31	2010-12-31	2010-09-30	2010-06-30	2010-03-31	2009-12-31	2009-09-30	2009-06-30	2009-03-31	2008-12-31	2008-09-30	2008-06-30	2008-03-31	2007-12-31	2007-09-30	2007-06-30	2007-03-31	2006-12-31	2006-09-30	2006-06-30	2006-03-31	2005-12-31	2005-09-30	2005-06-30	2005-03-31	2004-12-31	2004-09-30	2004-06-30

statements of operations
revenues:
net product revenues	672,212,000	468,538,000	450,831,000	420,146,000	410,088,000	365,163,000	346,288,000	313,153,000	305,705,000	276,328,000	261,675,000	232,267,000	213,515,000	186,872,000	198,514,000	167,044,000	160,811,000	135,769,000	112,843,000	99,206,000	77,533,000	71,938,000
net revenues from collaborations	61,496,000	99,185,000	106,948,000	57,387,000	227,338,000	118,548,000	76,407,000	427,472,000	5,844,000	36,462,000	70,645,000	29,297,000	9,025,000	25,945,000	59,625,000	20,136,000	59,395,000	41,797,000	50,719,000	26,647,000	26,429,000	27,538,000
royalty revenue	39,981,000	26,466,000	35,387,000	23,386,000	22,399,000	10,622,000	17,023,000	9,905,000	7,205,000	6,500,000	2,715,000	2,742,000	2,278,000	442,000	396,000	453,000	347,000
total revenues	773,689,000	594,189,000	593,166,000	500,919,000	659,825,000	494,333,000	439,718,000	750,530,000	318,754,000	319,290,000	335,035,000	264,306,000	224,818,000	213,259,000	258,535,000	187,633,000	220,553,000	177,566,000	163,562,000	125,853,000	103,962,000	99,476,000	71,681,000	70,061,000	44,714,000	33,294,000	21,033,000	2,069,000
yoy	17.26%	20.20%	34.90%	-33.26%	107.00%	54.82%	31.25%	183.96%	41.78%	49.72%	29.59%	40.86%	1.93%	20.10%	58.07%	49.09%	112.15%	78.50%	128.18%	79.63%	132.50%	198.78%	240.80%	3286.23%
qoq	30.21%	0.17%	18.42%	-24.08%	33.48%	12.42%	-41.41%	135.46%	-0.17%	-4.70%	26.76%	17.56%	5.42%	-17.51%	37.79%	-14.93%	24.21%	8.56%	29.96%	21.06%	4.51%	38.78%	2.31%	56.69%	34.30%	58.29%	916.58%
operating costs and expenses:
cost of goods sold	142,029,000	70,183,000	102,649,000	81,980,000	67,271,000	54,613,000	71,975,000	79,473,000	75,336,000	41,432,000	46,172,000	36,507,000	34,038,000	23,457,000	33,635,000	28,091,000	30,256,000	23,023,000	23,024,000	21,797,000	19,929,000	13,302,000	12,176,000	5,213,000	4,326,000	3,347,000	1,665,000	137,000
gross profit	631,660,000	524,006,000	490,517,000	418,939,000	592,554,000	439,720,000	367,743,000	671,057,000	243,418,000	277,858,000	288,863,000	227,799,000	190,780,000	189,802,000	224,900,000	159,542,000	190,297,000	154,543,000	140,538,000	104,056,000	84,033,000	86,174,000	59,505,000	64,848,000	40,388,000	29,947,000	19,368,000	1,932,000
yoy	6.60%	19.17%	33.39%	-37.57%	143.43%	58.25%	27.31%	194.58%	27.59%	46.39%	28.44%	42.78%	0.25%	22.82%	60.03%	53.32%	126.46%	79.34%	136.18%	60.46%	108.06%	187.76%	207.23%	3256.52%
qoq	20.54%	6.83%	17.09%	-29.30%	34.76%	19.57%	-45.20%	175.68%	-12.39%	-3.81%	26.81%	19.40%	0.52%	-15.61%	40.97%	-16.16%	23.14%	9.97%	35.06%	23.83%	-2.48%	44.82%	-8.24%	60.56%	34.86%	54.62%	902.48%
gross margin %	81.64%	88.19%	82.69%	83.63%	89.80%	88.95%	83.63%	89.41%	76.37%	87.02%	86.22%	86.19%	84.86%	89.00%	86.99%	85.03%	86.28%	87.03%	85.92%	82.68%	80.83%	86.63%	83.01%	92.56%	90.33%	89.95%	92.08%	93.38%
cost of collaborations and royalties	924,000	858,000	168,000	3,925,000	1,401,000	11,363,000	13,883,000	4,836,000	10,034,000	13,437,000	5,094,000	4,609,000	6,770,000	12,170,000	4,029,000	4,572,000	8,499,000
research and development	323,621,000	265,122,000	300,169,000	270,926,000	294,142,000	260,995,000	272,141,000	253,179,000	248,526,000	230,569,000	262,039,000	245,371,000	205,712,000	169,893,000	229,050,000	194,572,000	182,635,000	185,899,000	168,469,000	161,783,000	154,996,000	169,571,000	201,301,000	160,796,000	163,890,000	129,127,000	131,036,000	139,945,000	137,582,000	96,857,000	117,772,000	95,252,000	90,627,000	86,984,000						23,369,000	24,274,000	25,303,000	26,349,000	26,080,000	27,468,000	28,136,000	24,700,000	21,575,000	23,219,000	38,615,000	25,321,000	24,943,000	22,105,000	29,558,000	20,277,000	15,584,000	59,618,000	18,813,000	26,671,000	12,343,000	12,833,000	12,692,000	11,930,000	12,762,000	7,995,000	9,190,000	5,372,000	5,178,000	4,831,000	4,159,000
selling, general and administrative	323,314,000	239,949,000	295,339,000	220,993,000	248,397,000	210,797,000	198,123,000	199,175,000	214,689,000	183,659,000	210,344,000	235,859,000	169,984,000	154,471,000	186,382,000	142,075,000	145,323,000	146,859,000	166,291,000	167,472,000	127,896,000	126,761,000	156,277,000	120,351,000	112,769,000	89,608,000	108,688,000	116,545,000
total operating costs and expenses	789,888,000	576,112,000	698,325,000	577,824,000	611,211,000	537,768,000	556,122,000	536,663,000	548,585,000	469,097,000	523,649,000	522,346,000	416,504,000	359,991,000	453,096,000	369,310,000	366,713,000	363,820,000	357,784,000	351,052,000	302,821,000	309,634,000																																														7,091,250	7,793,000	7,106,000
income from operations	-16,199,000	18,077,000	-105,159,000	-76,905,000	48,614,000	-43,435,000	-116,404,000	213,867,000	-229,831,000	-149,807,000	-188,614,000	-258,040,000	-191,686,000	-146,732,000	-194,561,000	-181,677,000	-146,160,000	-186,254,000	-194,222,000	-225,199,000	-198,859,000	-210,158,000	-298,073,000	-216,299,000	-236,271,000	-188,788,000	-220,356,000	-254,558,000	-192,354,000	-147,405,000	-147,303,000	-125,800,000	-120,474,000	-106,511,000						-13,586,000	-12,438,000	-13,118,000	-15,676,000	-12,410,000	-8,728,000	-11,626,000	-11,306,000	-8,069,000	-9,650,000	-22,412,000	-7,980,000	-7,813,000	-3,234,000	-12,831,000	-3,957,000	-2,892,000	-51,338,000	-14,953,000	-23,994,000	-9,991,000	-8,604,000	-11,109,000	-9,797,000	-14,917,000	-10,670,000	-11,204,000	-6,681,000	-6,683,250	-6,426,000	-6,975,000
yoy	-133.32%	-141.62%	-9.66%	-135.96%	-121.15%	-71.01%	-38.28%	-182.88%	19.90%	2.10%	-3.06%	42.03%	31.15%	-21.22%	0.17%	-19.33%	-26.50%	-11.37%	-34.84%	4.11%	-15.83%	11.32%	35.27%	-15.03%	22.83%	28.07%	49.59%	102.35%	59.66%	38.39%										9.48%	42.51%	12.83%	38.65%	53.80%	-9.55%	-48.13%	41.68%	3.28%	198.39%	74.67%	101.67%	170.16%	-93.70%	-14.19%	-83.51%	-71.05%	496.68%	34.60%	144.91%	-33.02%	-19.36%	-0.85%	46.64%	123.20%	66.04%	60.63%
qoq	-189.61%	-117.19%	36.74%	-258.20%	-211.92%	-62.69%	-154.43%	-193.05%	53.42%	-20.57%	-26.91%	34.62%	30.64%	-24.58%	7.09%	24.30%	-21.53%	-4.10%	-13.76%	13.25%	-5.38%	-29.49%	37.81%	-8.45%	25.15%	-14.33%	-13.44%	32.34%	30.49%	0.07%	17.09%	4.42%	13.11%							9.23%	-5.18%	-16.32%	26.32%	42.19%	-24.93%	2.83%	40.12%	-16.38%	-56.94%	180.85%	2.14%	141.59%	-74.80%	224.26%	36.83%	-94.37%	243.33%	-37.68%	140.16%	16.12%	-22.55%	13.39%	-34.32%	39.80%	-4.77%	67.70%	-0.03%	4.00%	-7.87%
operating margin %	-2.09%	3.04%	-17.73%	-15.35%	7.37%	-8.79%	-26.47%	28.50%	-72.10%	-46.92%	-56.30%	-97.63%	-85.26%	-68.80%	-75.26%	-96.83%	-66.27%	-104.89%	-118.75%	-178.94%	-191.28%	-211.27%	-415.83%	-308.73%	-528.40%	-567.03%	-1047.67%	-12303.43%
other income:
interest expense	-40,246,000	-38,646,000	-38,971,000	-34,376,000	-33,258,000	-35,253,000	-31,338,000	-30,893,000	-30,035,000	-28,955,000	-29,913,000	-41,084,000	-42,609,000	-42,362,000	-36,816,000	-40,274,000	-33,416,000	-32,515,000	-28,517,000	-28,731,000	-27,248,000																															-256,000	-176,000	-208,000	-232,000	-250,000	-272,000	-275,000	-286,000	-296,000	-265,000	-230,000	-238,000	-252,000	-244,000	-248,000	-225,000	-181,000	-175,000	-97,000
interest income	27,486,000	28,673,000	31,019,000	32,146,000	29,182,000	29,645,000	30,406,000	25,425,000	21,075,000	18,655,000				1,012,000	495,000	225,000	409,000	450,000	1,092,000	2,072,000	3,165,000	5,480,000	7,253,000	9,889,000	8,781,000	7,525,000	10,571,000	6,796,000	6,101,000	5,794,000	4,235,000	3,296,000	2,577,000	2,128,000						236,000	265,000	322,000	382,000	472,000	602,000	641,000	590,000	843,000	1,036,000	1,458,000	2,048,000	2,679,000	3,486,000	3,547,000	4,702,000	5,814,000	4,311,000	2,578,000	2,690,000	1,824,000	1,555,000	1,538,000	1,260,000	790,000	237,000	258,000	264,000	208,000	185,000	74,000
other income	-6,399,000	-49,700,000	-80,847,000	-29,528,000	-55,705,000	-14,544,000	-20,351,000	-57,658,000	-35,418,000	-12,255,000	11,506,000	-30,233,000	-40,378,000	-51,274,000	-29,420,000	17,490,000	-9,164,000	19,044,000	-21,952,000	-594,000	45,039,000	23,032,000	14,237,000	-2,519,000	-453,000	43,000	-1,295,000	2,925,000	2,208,000	335,000	841,000	-433,000	-523,000	-2,907,000						1,000	-597,000	-16,000	81,000	6,351,000	20,000	43,000	-11,000	484,000	-10,000	-24,000	178,000	-71,000	-1,546,000	-412,000	82,000	-14,000	-169,000	-41,000	-55,000	25,000	-86,000	-109,000	-85,000	-112,000	-1,000	49,000	42,000	-196,000		42,000
total other income	-19,159,000	-59,673,000	-88,799,000	-31,758,000	-59,781,000	-20,152,000	-21,283,000	-63,126,000	-44,378,000	-22,555,000	-18,407,000	-147,903,000	-82,987,000	-92,624,000	-65,741,000	-22,559,000	-42,171,000	-13,021,000	-49,377,000	-27,253,000	20,956,000	28,512,000	21,490,000	7,370,000	17,750,000	7,568,000	9,276,000	9,721,000	28,873,000	6,129,000	5,076,000	2,863,000	2,054,000	-779,000						-717,000	-799,000	-706,000	-609,000	5,907,000	-604,000	-3,235,000	-999,000	-161,000	-110,000	618,000	756,000	-1,523,000	-417,000	1,322,000	2,923,000	4,614,000	3,731,000	2,262,000	2,349,000	1,553,000	1,204,000	1,199,000	937,000	426,000	-8,000	59,000	81,000	-55,250	10,000	19,000
income before income taxes	-35,358,000	-41,596,000	-193,958,000	-108,663,000	-11,167,000	-63,587,000	-137,687,000	150,741,000	-274,209,000	-172,362,000	-207,021,000	-405,943,000	-274,673,000	-239,356,000	-260,302,000	-204,236,000	-188,331,000	-199,275,000	-243,599,000	-252,452,000	-177,903,000	-181,646,000	-276,583,000	-208,929,000	-218,521,000	-181,220,000	-211,080,000	-244,837,000	-163,481,000	-141,276,000										-14,303,000	-13,237,000	-13,824,000	-16,285,000	-6,503,000	-9,332,000	-14,861,000	-12,305,000	-8,230,000	-9,760,000	-21,794,000	-7,224,000	-9,336,000	-3,651,000	-11,509,000	-1,034,000	1,722,000	-47,607,000
benefit from income taxes	-30,919,000	-15,883,000	110,195,000	-2,907,000	-5,722,000	-2,348,000			-1,815,000	-1,739,000	-472,000	23,000	-2,729,000	-985,000	-630,500	-278,000	-1,228,000	-1,016,000			-1,326,000	-575,000			-960,000		-361,000	-445,000	-79,000	62,000																229,000	-18,000	439,000	552,000	-908,000	-665,000	-56,000	793,000	-1,251,000	-205,000	-60,000	-5,185,000
net income	-66,277,000	-57,479,000	-83,763,000	-111,570,000	-16,889,000	-65,935,000	-137,870,000	147,753,000	-276,024,000	-174,101,000	-207,493,000	-405,920,000	-277,402,000	-240,341,000	-258,460,000	-204,514,000	-189,559,000	-200,291,000	-243,540,000	-253,291,000	-179,229,000	-182,221,000	-276,185,000	-208,535,000	-219,481,000	-181,915,000	-211,441,000	-245,282,000	-163,560,000	-141,214,000	-142,227,000	-122,937,000	-118,420,000	-107,290,000						-14,303,000	-13,237,000	-13,824,000	-16,285,000	-6,930,000	-9,630,000	-14,632,000	-12,323,000	-7,791,000	-9,208,000	-22,702,000	-7,889,000	-9,392,000	-2,858,000	-12,760,000	-1,239,000	1,662,000	-52,792,000	-12,691,000	-21,645,000	-8,438,000	-7,400,000	-9,910,000	-8,860,000	-14,491,000	-10,678,000	-11,145,000	-6,600,000	-5,700,000	-6,416,000	-6,956,000
yoy	292.43%	-12.82%	-39.24%	-175.51%	-93.88%	-62.13%	-33.55%	-136.40%	-0.50%	-27.56%	-19.72%	98.48%	46.34%	20.00%	6.13%	-19.26%	5.76%	9.92%	-11.82%	21.46%	-18.34%	0.17%	30.62%	-14.98%	34.19%	28.82%	48.66%	99.52%	38.12%	31.62%										106.39%	37.46%	-5.52%	32.15%	-11.05%	4.58%	-35.55%	56.20%	-17.05%	222.18%	77.92%	536.72%	-665.10%	-94.59%	0.54%	-94.28%	-119.70%	613.41%	28.06%	144.30%	-41.77%	-30.70%	-11.08%	34.24%	154.23%	66.43%	60.22%
qoq	15.31%	-31.38%	-24.92%	560.61%	-74.39%	-52.18%	-193.31%	-153.53%	58.54%	-16.09%	-48.88%	46.33%	15.42%	-7.01%	26.38%	7.89%	-5.36%	-17.76%	-3.85%	41.32%	-1.64%	-34.02%	32.44%	-4.99%	20.65%	-13.96%	-13.80%	49.96%	15.82%	-0.71%	15.69%	3.81%	10.37%							8.05%	-4.25%	-15.11%	134.99%	-28.04%	-34.19%	18.74%	58.17%	-15.39%	-59.44%	187.77%	-16.00%	228.62%	-77.60%	929.86%	-174.55%	-103.15%	315.98%	-41.37%	156.52%	14.03%	-25.33%	11.85%	-38.86%	35.71%	-4.19%	68.86%	15.79%	-11.16%	-7.76%
net income margin %	-8.57%	-9.67%	-14.12%	-22.27%	-2.56%	-13.34%	-31.35%	19.69%	-86.59%	-54.53%	-61.93%	-153.58%	-123.39%	-112.70%	-99.97%	-109.00%	-85.95%	-112.80%	-148.90%	-201.26%	-172.40%	-183.18%	-385.30%	-297.65%	-490.86%	-546.39%	-1005.28%	-11855.10%
net income per common share — basic and diluted	-510	-440																																						-340	-310	-330	-380	-170	-230	-350	-290	-180	-220	-550		-230	-70	-310	-30	80	-1,350	-340	-580	-260	-230	-310	-300	-590	-510	-540	-320
weighted-average common shares used to compute basic and diluted net income per common share	130,628,000	129,676,000	127,651,000		126,733,000	126,138,000	124,906,000		124,659,000	124,111,000	121,689,000	122,166,000	120,896,000	120,393,000	118,451,000	119,141,000	117,772,000	117,080,000	114,986,000	115,986,000	114,911,000	112,748,000	109,264,000	108,701,000	108,576,000	105,400,000	100,590,000	100,783,000	100,519,000	99,979,000	90,554,000	91,828,000	88,098,000	86,027,000						42,410,000	42,654,000	42,379,000	42,345,000	42,040,000	42,123,000	41,991,000	41,870,000	41,633,000	41,708,000	41,520,000	41,399,000	41,077,000	41,197,000	40,908,000	40,736,000	38,657,000				31,890,000	32,122,000	32,010,000	30,028,000	21,949,000	20,913,576,000	20,605,681,000	20,434,896,000	11,886,126,000	19,507,468,000	6,997,479,000
statements of comprehensive loss
other comprehensive income:
unrealized gain on marketable securities	-343,000	1,030,000	-4,787,000	9,078,000	-727,000	-3,568,000	7,040,000	1,878,000	-2,025,000	4,125,000					-1,666,000	-64,000	-247,000	-1,000																						-14,000	95,000	-228,000	-732,000	-574,000	2,000	492,000	107,000	-1,169,000	272,000	1,021,000	-473,000	2,175,000	130,000		336,000	150,000	273,000	-94,000		-12,000	104,000	26,000				33,000
foreign currency translation gain	7,855,000		-3,316,000	703,000	-6,952,000	-78,000	3,566,000	2,873,000	4,073,000	1,410,000	-5,651,000	460,000	-2,459,000	2,376,000	1,868,000	1,857,000
defined benefit pension plans, net of tax	53,000	55,000	-1,589,000	30,000	30,000	33,000	-1,642,000	-10,000	-4,000	-5,000	1,616,000	34,000	34,000	35,000	769,000	58,000	58,000	58,000	-456,000	76,000	72,000	74,000
total other comprehensive income	7,565,000		-9,692,000	9,811,000	-7,649,000	-3,613,000	8,964,000	4,741,000	2,044,000	5,530,000	-871,000	-1,559,000	-4,159,000	-4,806,000	971,000	1,851,000	636,000	6,905,000	-168,750	-3,981,000	-1,153,000
comprehensive loss	-58,712,000	-60,478,000			-24,538,000	-69,548,000			-273,980,000	-168,571,000	-208,364,000	-407,479,000	-281,561,000	-245,147,000	-257,489,000	-202,663,000	-188,923,000	-193,386,000	-249,969,000	-257,272,000	-180,382,000	-177,762,000	-278,332,000	-207,075,000	-222,459,000	-181,555,000	-211,262,000	-244,867,000	-162,514,000	-141,634,000	-142,919,000	-122,719,000	-118,551,000	-107,677,000						-14,317,000	-13,142,000	-14,052,000	-17,017,000	-7,504,000	-9,628,000	-14,169,000	-12,216,000	-8,964,000	-8,940,000	-21,704,000	-8,452,000	-7,108,000	-2,295,000	-15,067,000	-893,000	1,819,000	-53,206,000	-12,757,000	-21,662,000	-8,061,000	-7,249,000	-9,726,000	-8,790,000	-14,601,000	-10,677,000	-11,368,000	-6,829,000	-5,344,000	-6,322,000	-7,062,000
other comprehensive loss:
foreign currency translation loss		-4,084,000
total other comprehensive loss		-2,999,000
net income per common share - basic			-382.5	-870			-607.5	1,180
net income per common share - diluted			-382.5	-870			-607.5	1,150
weighted-average common shares - basic				128,590,000
weighted-average common shares - diluted				128,590,000
statements of comprehensive income
comprehensive income			-48,961,250	-101,759,000			-72,514,250	152,494,000
net income per common share - basic and diluted					-130	-520			-2,210	-1,400	-1,905	-3,320	-2,290	-2,000	-1,260	-1,720	-1,610	-1,710	-1,342.5	-2,180	-1,560	-1,620	-1,407.5	-1,920	-2,020	-1,730	-1,370	-2,430	-1,630	-1,410	-982.5	-1,340	-1,340	-1,250																	-190
loss on the extinguishment of debt												-76,586,000
(benefit from) benefit from income taxes							-1,635,500	-2,988,000																																				-21,750	-298,000
weighted-average common shares- basic								125,220,000
weighted-average common shares- diluted								131,337,000
unrealized loss on marketable securities											-2,751,000	-2,053,000	-1,734,000	-7,217,000																																								-1,808,000					-71,000				-1,000	-39,000	9,000		-31,000
foreign currency translation gains																	825,000	6,848,000	-416,250	-2,576,000
cost of collaborations																		8,039,000
change in fair value of liability obligation																									9,422,000
benefit for income taxes																			-685,000	-839,000			-315,250	394,000		-695,000
unrealized gain on marketable debt securities																			192,000	-1,481,000	-1,796,000	4,045,000
foreign currency translation																					571,000	340,000	570,250	1,439,000	842,000																					-29,000		-4,000	-4,000	-23,000	-90,000	109,000	433,000	-499,000	10,000
product revenues																							27,647,000	46,066,000	38,231,000	26,291,000	12,075,000	460,000
net revenue from collaborators																							9,370,250	23,995,000	6,483,000	7,003,000
costs and expenses:
total costs and expenses																							197,356,750	286,360,000	280,985,000	222,082,000	241,389,000	256,627,000																																12,364,750	16,815,000	17,130,000	15,514,000	16,469,000	12,083,000	12,312,000	8,324,000
gain on litigation settlement																													20,564,000
comprehensive loss:
unrealized gain on marketable securities, net of tax																							193,000	-50,000	462,000	360,000	179,000	415,000	1,046,000		-548,500	218,000
defined benefit pension plans																							691,000	71,000
unrealized loss on pension obligation																									-4,282,000
net revenues from collaborators																											8,958,000	1,609,000	29,907,000	21,899,000	37,924,000	17,096,000	15,932,000	18,960,000
reclassification adjustment for realized loss on marketable securities included in net income
operating expenses:
general and administrative																													84,679,000	72,447,000	67,455,000	47,644,000	45,779,000	38,487,000						10,672,000	8,955,000	8,429,000	10,224,000	7,522,000	8,928,000	10,107,000	11,170,000	13,120,000	10,680,000	8,398,000	7,716,000	7,274,000	6,863,000	7,106,000	5,872,000	5,540,000	8,035,000	5,273,000	4,540,000	4,629,000	3,982,000	4,438,000	3,584,000	3,707,000	4,088,000	3,122,000	2,952,000	2,999,000	2,962,000	2,947,000
total operating expenses																													222,261,000	169,304,000	185,227,000	142,896,000	136,406,000	125,471,000						34,041,000	33,229,000	33,732,000	36,573,000	33,602,000	36,396,000	38,243,000	35,870,000	34,695,000	33,899,000	47,013,000	33,037,000	32,217,000	28,968,000	36,664,000	26,149,000	21,124,000	67,653,000	24,086,000	31,211,000
unrealized loss on marketable securities, net of tax																														-420,000			-476,000	-1,936,000
reclassification adjustment for realized gain on marketable securities included in net income																																	345,000	1,549,000
net revenues from research collaborators																																								20,455,000	20,791,000	20,614,000	20,897,000	21,192,000	27,668,000	26,617,000	24,564,000	26,626,000	24,249,000	24,601,000	25,057,000	24,404,000	25,734,000	23,833,000	22,192,000	18,232,000	16,315,000	9,133,000	7,217,000
equity in loss of joint venture																																								-954,000	-467,000	-1,012,000	-1,072,000	-916,000	-1,226,000	-3,919,000	-1,578,000	-1,488,000	-1,136,000	-816,000	-1,470,000	-3,875,000	-2,181,000	-1,605,000	-1,629,000	-936,000	-139,000
non-cash stock-based compensation expenses included in operating expenses are as follows:
weighted-average common shares — basic and diluted																																																									39,025,000	37,534,000	37,376,000
foreign currency translation adjustments																																																								-151,250	-687,000	28,000	54,000	69,000	47,000	158,000	71,000	-71,000	-8,000	-256,000	-198,000	412,000	94,000	-106,000
non-cash stock-based compensation expense included in these amounts are as follows:
net revenues																																																												4,987,250	8,211,000	6,021,000	5,717,000	1,041,000	1,413,000	1,108,000	1,643,000
cost and expenses:
total non-cash stock-based compensation																																																															2,375,000	1,002,000	2,196,000	919,000	480,000
accretion of redeemable convertible preferred stock																																																																						-751,000
net income attributable to common stockholders																																																																-14,491,000	-10,678,000	-11,145,000	-6,600,000	-5,700,000	-6,416,000	-7,707,000
revenue from research collaborators																																																																				408,000	1,367,000	131,000
in-process research and development
net income per common share																																																																				-785	-330	-1,100
noncash stock-based compensation expense included in these amounts are as follows:
total stock-based compensation																																																																				728,750	731,000	-47,000
costs and expenses
noncash stock-based compensation income included in these amounts are as follows:

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