7Baggers
Quarterly
Annual
    Unit: USD2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2015-12-31 2014-12-31 2013-12-31 2012-12-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 2009-12-31 2009-09-30 2009-06-30 2009-03-31 2008-12-31 2008-09-30 2008-06-30 2008-03-31 2007-12-31 2007-09-30 2007-06-30 2007-03-31 2006-12-31 2006-09-30 2006-06-30 2006-03-31 2005-12-31 2005-09-30 2005-06-30 2005-03-31 2004-12-31 2004-09-30 2004-06-30 
      
    		                                                                       
      statements of operations
    		                                                                       
      revenues:
    		                                                                       
      net product revenues
    		851,082,000 672,212,000 468,538,000 450,831,000 420,146,000 410,088,000 365,163,000 346,288,000 313,153,000 305,705,000 276,328,000 261,675,000 232,267,000 213,515,000 186,872,000 198,514,000 167,044,000 160,811,000 135,769,000 112,843,000 99,206,000 77,533,000 71,938,000                                                 
      net revenues from collaborations
    		351,742,000 61,496,000 99,185,000 106,948,000 57,387,000 227,338,000 118,548,000 76,407,000 427,472,000 5,844,000 36,462,000 70,645,000 29,297,000 9,025,000 25,945,000 59,625,000 20,136,000 59,395,000 41,797,000 50,719,000 26,647,000 26,429,000 27,538,000                                                 
      royalty revenue
    		46,202,000 39,981,000 26,466,000 35,387,000 23,386,000 22,399,000 10,622,000 17,023,000 9,905,000 7,205,000 6,500,000 2,715,000 2,742,000 2,278,000 442,000 396,000 453,000 347,000                                                      
      total revenues
    		1,249,026,000 773,689,000 594,189,000 593,166,000 500,919,000 659,825,000 494,333,000 439,718,000 750,530,000 318,754,000 319,290,000 335,035,000 264,306,000 224,818,000 213,259,000 258,535,000 187,633,000 220,553,000 177,566,000 163,562,000 125,853,000 103,962,000 99,476,000 71,681,000 70,061,000 44,714,000 33,294,000 21,033,000 2,069,000                                           
      yoy
    		149.35% 17.26% 20.20% 34.90% -33.26% 107.00% 54.82% 31.25% 183.96% 41.78% 49.72% 29.59% 40.86% 1.93% 20.10% 58.07% 49.09% 112.15% 78.50% 128.18% 79.63% 132.50% 198.78% 240.80% 3286.23%                                               
      qoq
    		61.44% 30.21% 0.17% 18.42% -24.08% 33.48% 12.42% -41.41% 135.46% -0.17% -4.70% 26.76% 17.56% 5.42% -17.51% 37.79% -14.93% 24.21% 8.56% 29.96% 21.06% 4.51% 38.78% 2.31% 56.69% 34.30% 58.29% 916.58%                                            
      operating costs and expenses:
    		                                                                       
      cost of goods sold
    		197,231,000 142,029,000 70,183,000 102,649,000 81,980,000 67,271,000 54,613,000 71,975,000 79,473,000 75,336,000 41,432,000 46,172,000 36,507,000 34,038,000 23,457,000 33,635,000 28,091,000 30,256,000 23,023,000 23,024,000 21,797,000 19,929,000 13,302,000 12,176,000 5,213,000 4,326,000 3,347,000 1,665,000 137,000                                           
      gross profit
    		1,051,795,000 631,660,000 524,006,000 490,517,000 418,939,000 592,554,000 439,720,000 367,743,000 671,057,000 243,418,000 277,858,000 288,863,000 227,799,000 190,780,000 189,802,000 224,900,000 159,542,000 190,297,000 154,543,000 140,538,000 104,056,000 84,033,000 86,174,000 59,505,000 64,848,000 40,388,000 29,947,000 19,368,000 1,932,000                                           
      yoy
    		151.06% 6.60% 19.17% 33.39% -37.57% 143.43% 58.25% 27.31% 194.58% 27.59% 46.39% 28.44% 42.78% 0.25% 22.82% 60.03% 53.32% 126.46% 79.34% 136.18% 60.46% 108.06% 187.76% 207.23% 3256.52%                                               
      qoq
    		66.51% 20.54% 6.83% 17.09% -29.30% 34.76% 19.57% -45.20% 175.68% -12.39% -3.81% 26.81% 19.40% 0.52% -15.61% 40.97% -16.16% 23.14% 9.97% 35.06% 23.83% -2.48% 44.82% -8.24% 60.56% 34.86% 54.62% 902.48%                                            
      gross margin %
    		84.21% 81.64% 88.19% 82.69% 83.63% 89.80% 88.95% 83.63% 89.41% 76.37% 87.02% 86.22% 86.19% 84.86% 89.00% 86.99% 85.03% 86.28% 87.03% 85.92% 82.68% 80.83% 86.63% 83.01% 92.56% 90.33% 89.95% 92.08% 93.38%                                           
      cost of collaborations and royalties
    		2,923,000 924,000 858,000 168,000 3,925,000 1,401,000 11,363,000 13,883,000 4,836,000 10,034,000 13,437,000 5,094,000 4,609,000 6,770,000 12,170,000 4,029,000 4,572,000 8,499,000                                                      
      research and development
    		358,814,000 323,621,000 265,122,000 300,169,000 270,926,000 294,142,000 260,995,000 272,141,000 253,179,000 248,526,000 230,569,000 262,039,000 245,371,000 205,712,000 169,893,000 229,050,000 194,572,000 182,635,000 185,899,000 168,469,000 161,783,000 154,996,000 169,571,000 201,301,000 160,796,000 163,890,000 129,127,000 131,036,000 139,945,000 137,582,000 96,857,000 117,772,000 95,252,000 90,627,000 86,984,000      23,369,000 24,274,000 25,303,000 26,349,000 26,080,000 27,468,000 28,136,000 24,700,000 21,575,000 23,219,000 38,615,000 25,321,000 24,943,000 22,105,000 29,558,000 20,277,000 15,584,000 59,618,000 18,813,000 26,671,000 12,343,000 12,833,000 12,692,000 11,930,000 12,762,000 7,995,000 9,190,000 5,372,000 5,178,000 4,831,000 4,159,000 
      selling, general and administrative
    		322,076,000 323,314,000 239,949,000 295,339,000 220,993,000 248,397,000 210,797,000 198,123,000 199,175,000 214,689,000 183,659,000 210,344,000 235,859,000 169,984,000 154,471,000 186,382,000 142,075,000 145,323,000 146,859,000 166,291,000 167,472,000 127,896,000 126,761,000 156,277,000 120,351,000 112,769,000 89,608,000 108,688,000 116,545,000                                           
      total operating costs and expenses
    		881,044,000 789,888,000 576,112,000 698,325,000 577,824,000 611,211,000 537,768,000 556,122,000 536,663,000 548,585,000 469,097,000 523,649,000 522,346,000 416,504,000 359,991,000 453,096,000 369,310,000 366,713,000 363,820,000 357,784,000 351,052,000 302,821,000 309,634,000                                              7,091,250 7,793,000 7,106,000 
      income from operations
    		367,982,000 -16,199,000 18,077,000 -105,159,000 -76,905,000 48,614,000 -43,435,000 -116,404,000 213,867,000 -229,831,000 -149,807,000 -188,614,000 -258,040,000 -191,686,000 -146,732,000 -194,561,000 -181,677,000 -146,160,000 -186,254,000 -194,222,000 -225,199,000 -198,859,000 -210,158,000 -298,073,000 -216,299,000 -236,271,000 -188,788,000 -220,356,000 -254,558,000 -192,354,000 -147,405,000 -147,303,000 -125,800,000 -120,474,000 -106,511,000      -13,586,000 -12,438,000 -13,118,000 -15,676,000 -12,410,000 -8,728,000 -11,626,000 -11,306,000 -8,069,000 -9,650,000 -22,412,000 -7,980,000 -7,813,000 -3,234,000 -12,831,000 -3,957,000 -2,892,000 -51,338,000 -14,953,000 -23,994,000 -9,991,000 -8,604,000 -11,109,000 -9,797,000 -14,917,000 -10,670,000 -11,204,000 -6,681,000 -6,683,250 -6,426,000 -6,975,000 
      yoy
    		-578.49% -133.32% -141.62% -9.66% -135.96% -121.15% -71.01% -38.28% -182.88% 19.90% 2.10% -3.06% 42.03% 31.15% -21.22% 0.17% -19.33% -26.50% -11.37% -34.84% 4.11% -15.83% 11.32% 35.27% -15.03% 22.83% 28.07% 49.59% 102.35% 59.66% 38.39%          9.48% 42.51% 12.83% 38.65% 53.80% -9.55% -48.13% 41.68% 3.28% 198.39% 74.67% 101.67% 170.16% -93.70% -14.19% -83.51% -71.05% 496.68% 34.60% 144.91% -33.02% -19.36% -0.85% 46.64% 123.20% 66.04% 60.63%     
      qoq
    		-2371.63% -189.61% -117.19% 36.74% -258.20% -211.92% -62.69% -154.43% -193.05% 53.42% -20.57% -26.91% 34.62% 30.64% -24.58% 7.09% 24.30% -21.53% -4.10% -13.76% 13.25% -5.38% -29.49% 37.81% -8.45% 25.15% -14.33% -13.44% 32.34% 30.49% 0.07% 17.09% 4.42% 13.11%       9.23% -5.18% -16.32% 26.32% 42.19% -24.93% 2.83% 40.12% -16.38% -56.94% 180.85% 2.14% 141.59% -74.80% 224.26% 36.83% -94.37% 243.33% -37.68% 140.16% 16.12% -22.55% 13.39% -34.32% 39.80% -4.77% 67.70% -0.03% 4.00% -7.87%  
      operating margin %
    		29.46% -2.09% 3.04% -17.73% -15.35% 7.37% -8.79% -26.47% 28.50% -72.10% -46.92% -56.30% -97.63% -85.26% -68.80% -75.26% -96.83% -66.27% -104.89% -118.75% -178.94% -191.28% -211.27% -415.83% -308.73% -528.40% -567.03% -1047.67% -12303.43%                                           
      other income:
    		                                                                       
      interest expense
    		-44,398,000 -40,246,000 -38,646,000 -38,971,000 -34,376,000 -33,258,000 -35,253,000 -31,338,000 -30,893,000 -30,035,000 -28,955,000 -29,913,000 -41,084,000 -42,609,000 -42,362,000 -36,816,000 -40,274,000 -33,416,000 -32,515,000 -28,517,000 -28,731,000 -27,248,000                               -256,000 -176,000 -208,000 -232,000 -250,000 -272,000 -275,000 -286,000 -296,000 -265,000 -230,000 -238,000 -252,000 -244,000 -248,000 -225,000 -181,000 -175,000 -97,000 
      interest income
    		28,681,000 27,486,000 28,673,000 31,019,000 32,146,000 29,182,000 29,645,000 30,406,000 25,425,000 21,075,000 18,655,000    1,012,000 495,000 225,000 409,000 450,000 1,092,000 2,072,000 3,165,000 5,480,000 7,253,000 9,889,000 8,781,000 7,525,000 10,571,000 6,796,000 6,101,000 5,794,000 4,235,000 3,296,000 2,577,000 2,128,000      236,000 265,000 322,000 382,000 472,000 602,000 641,000 590,000 843,000 1,036,000 1,458,000 2,048,000 2,679,000 3,486,000 3,547,000 4,702,000 5,814,000 4,311,000 2,578,000 2,690,000 1,824,000 1,555,000 1,538,000 1,260,000 790,000 237,000 258,000 264,000 208,000 185,000 74,000 
      loss related to convertible debt
    		-39,146,000                                                                       
      other income
    		-74,150,000 -6,399,000 -49,700,000 -80,847,000 -29,528,000 -55,705,000 -14,544,000 -20,351,000 -57,658,000 -35,418,000 -12,255,000 11,506,000 -30,233,000 -40,378,000 -51,274,000 -29,420,000 17,490,000 -9,164,000 19,044,000 -21,952,000 -594,000 45,039,000 23,032,000 14,237,000 -2,519,000 -453,000 43,000 -1,295,000 2,925,000 2,208,000 335,000 841,000 -433,000 -523,000 -2,907,000      1,000 -597,000 -16,000 81,000 6,351,000 20,000 43,000 -11,000 484,000 -10,000 -24,000 178,000 -71,000 -1,546,000 -412,000 82,000 -14,000 -169,000 -41,000 -55,000 25,000 -86,000 -109,000 -85,000 -112,000 -1,000 49,000 42,000 -196,000  42,000 
      total other income
    		-129,013,000 -19,159,000 -59,673,000 -88,799,000 -31,758,000 -59,781,000 -20,152,000 -21,283,000 -63,126,000 -44,378,000 -22,555,000 -18,407,000 -147,903,000 -82,987,000 -92,624,000 -65,741,000 -22,559,000 -42,171,000 -13,021,000 -49,377,000 -27,253,000 20,956,000 28,512,000 21,490,000 7,370,000 17,750,000 7,568,000 9,276,000 9,721,000 28,873,000 6,129,000 5,076,000 2,863,000 2,054,000 -779,000      -717,000 -799,000 -706,000 -609,000 5,907,000 -604,000 -3,235,000 -999,000 -161,000 -110,000 618,000 756,000 -1,523,000 -417,000 1,322,000 2,923,000 4,614,000 3,731,000 2,262,000 2,349,000 1,553,000 1,204,000 1,199,000 937,000 426,000 -8,000 59,000 81,000 -55,250 10,000 19,000 
      income before income taxes
    		238,969,000 -35,358,000 -41,596,000 -193,958,000 -108,663,000 -11,167,000 -63,587,000 -137,687,000 150,741,000 -274,209,000 -172,362,000 -207,021,000 -405,943,000 -274,673,000 -239,356,000 -260,302,000 -204,236,000 -188,331,000 -199,275,000 -243,599,000 -252,452,000 -177,903,000 -181,646,000 -276,583,000 -208,929,000 -218,521,000 -181,220,000 -211,080,000 -244,837,000 -163,481,000 -141,276,000          -14,303,000 -13,237,000 -13,824,000 -16,285,000 -6,503,000 -9,332,000 -14,861,000 -12,305,000 -8,230,000 -9,760,000 -21,794,000 -7,224,000 -9,336,000 -3,651,000 -11,509,000 -1,034,000 1,722,000 -47,607,000              
      benefit from income taxes
    		12,115,000 -30,919,000 -15,883,000 110,195,000 -2,907,000 -5,722,000 -2,348,000   -1,815,000 -1,739,000 -472,000 23,000 -2,729,000 -985,000 -630,500 -278,000 -1,228,000 -1,016,000   -1,326,000 -575,000   -960,000  -361,000 -445,000 -79,000 62,000                229,000 -18,000 439,000 552,000 -908,000 -665,000 -56,000 793,000 -1,251,000 -205,000 -60,000 -5,185,000              
      net income
    		251,084,000 -66,277,000 -57,479,000 -83,763,000 -111,570,000 -16,889,000 -65,935,000 -137,870,000 147,753,000 -276,024,000 -174,101,000 -207,493,000 -405,920,000 -277,402,000 -240,341,000 -258,460,000 -204,514,000 -189,559,000 -200,291,000 -243,540,000 -253,291,000 -179,229,000 -182,221,000 -276,185,000 -208,535,000 -219,481,000 -181,915,000 -211,441,000 -245,282,000 -163,560,000 -141,214,000 -142,227,000 -122,937,000 -118,420,000 -107,290,000      -14,303,000 -13,237,000 -13,824,000 -16,285,000 -6,930,000 -9,630,000 -14,632,000 -12,323,000 -7,791,000 -9,208,000 -22,702,000 -7,889,000 -9,392,000 -2,858,000 -12,760,000 -1,239,000 1,662,000 -52,792,000 -12,691,000 -21,645,000 -8,438,000 -7,400,000 -9,910,000 -8,860,000 -14,491,000 -10,678,000 -11,145,000 -6,600,000 -5,700,000 -6,416,000 -6,956,000 
      yoy
    		-325.05% 292.43% -12.82% -39.24% -175.51% -93.88% -62.13% -33.55% -136.40% -0.50% -27.56% -19.72% 98.48% 46.34% 20.00% 6.13% -19.26% 5.76% 9.92% -11.82% 21.46% -18.34% 0.17% 30.62% -14.98% 34.19% 28.82% 48.66% 99.52% 38.12% 31.62%          106.39% 37.46% -5.52% 32.15% -11.05% 4.58% -35.55% 56.20% -17.05% 222.18% 77.92% 536.72% -665.10% -94.59% 0.54% -94.28% -119.70% 613.41% 28.06% 144.30% -41.77% -30.70% -11.08% 34.24% 154.23% 66.43% 60.22%     
      qoq
    		-478.84% 15.31% -31.38% -24.92% 560.61% -74.39% -52.18% -193.31% -153.53% 58.54% -16.09% -48.88% 46.33% 15.42% -7.01% 26.38% 7.89% -5.36% -17.76% -3.85% 41.32% -1.64% -34.02% 32.44% -4.99% 20.65% -13.96% -13.80% 49.96% 15.82% -0.71% 15.69% 3.81% 10.37%       8.05% -4.25% -15.11% 134.99% -28.04% -34.19% 18.74% 58.17% -15.39% -59.44% 187.77% -16.00% 228.62% -77.60% 929.86% -174.55% -103.15% 315.98% -41.37% 156.52% 14.03% -25.33% 11.85% -38.86% 35.71% -4.19% 68.86% 15.79% -11.16% -7.76%  
      net income margin %
    		20.10% -8.57% -9.67% -14.12% -22.27% -2.56% -13.34% -31.35% 19.69% -86.59% -54.53% -61.93% -153.58% -123.39% -112.70% -99.97% -109.00% -85.95% -112.80% -148.90% -201.26% -172.40% -183.18% -385.30% -297.65% -490.86% -546.39% -1005.28% -11855.10%                                           
      net income per common share — basic
    		1,910                                                                       
      net income per common share — diluted
    		1,840                                                                       
      weighted-average common shares — basic
    		131,447,000                                                                       
      weighted-average common shares — diluted
    		137,348,000                                                                       
      statements of comprehensive income
    		                                                                       
      other comprehensive income:
    		                                                                       
      unrealized gains on marketable securities
    		1,131,000                                                                       
      foreign currency translation gains
    		6,993,000                 825,000 6,848,000 -416,250 -2,576,000                                                   
      defined benefit pension plans, net of tax
    		53,000 53,000 55,000 -1,589,000 30,000 30,000 33,000 -1,642,000 -10,000 -4,000 -5,000 1,616,000 34,000 34,000 35,000 769,000 58,000 58,000 58,000 -456,000 76,000 72,000 74,000                                                 
      total other comprehensive income
    		8,177,000 7,565,000  -9,692,000 9,811,000 -7,649,000 -3,613,000 8,964,000 4,741,000 2,044,000 5,530,000 -871,000 -1,559,000 -4,159,000 -4,806,000 971,000 1,851,000 636,000 6,905,000 -168,750 -3,981,000 -1,153,000                                                  
      comprehensive income
    		259,261,000   -48,961,250 -101,759,000   -72,514,250 152,494,000                                                               
      net income per common share — basic and diluted
    		 -510 -440                                      -340 -310 -330 -380 -170 -230 -350 -290 -180 -220 -550  -230 -70 -310 -30 80 -1,350 -340 -580 -260 -230 -310 -300 -590 -510 -540 -320    
      weighted-average common shares used to compute basic and diluted net income per common share
    		 130,628,000 129,676,000 127,651,000  126,733,000 126,138,000 124,906,000  124,659,000 124,111,000 121,689,000 122,166,000 120,896,000 120,393,000 118,451,000 119,141,000 117,772,000 117,080,000 114,986,000 115,986,000 114,911,000 112,748,000 109,264,000 108,701,000 108,576,000 105,400,000 100,590,000 100,783,000 100,519,000 99,979,000 90,554,000 91,828,000 88,098,000 86,027,000      42,410,000 42,654,000 42,379,000 42,345,000 42,040,000 42,123,000 41,991,000 41,870,000 41,633,000 41,708,000 41,520,000 41,399,000 41,077,000 41,197,000 40,908,000 40,736,000 38,657,000    31,890,000 32,122,000 32,010,000 30,028,000 21,949,000 20,913,576,000 20,605,681,000 20,434,896,000 11,886,126,000 19,507,468,000 6,997,479,000 
      statements of comprehensive loss
    		                                                                       
      unrealized gain on marketable securities
    		 -343,000 1,030,000 -4,787,000 9,078,000 -727,000 -3,568,000 7,040,000 1,878,000 -2,025,000 4,125,000     -1,666,000 -64,000 -247,000 -1,000                      -14,000 95,000 -228,000 -732,000 -574,000 2,000 492,000 107,000 -1,169,000 272,000 1,021,000 -473,000 2,175,000 130,000  336,000 150,000 273,000 -94,000  -12,000 104,000 26,000    33,000     
      foreign currency translation gain
    		 7,855,000  -3,316,000 703,000 -6,952,000 -78,000 3,566,000 2,873,000 4,073,000 1,410,000 -5,651,000 460,000 -2,459,000 2,376,000 1,868,000 1,857,000                                                       
      comprehensive loss
    		 -58,712,000 -60,478,000   -24,538,000 -69,548,000   -273,980,000 -168,571,000 -208,364,000 -407,479,000 -281,561,000 -245,147,000 -257,489,000 -202,663,000 -188,923,000 -193,386,000 -249,969,000 -257,272,000 -180,382,000 -177,762,000 -278,332,000 -207,075,000 -222,459,000 -181,555,000 -211,262,000 -244,867,000 -162,514,000 -141,634,000 -142,919,000 -122,719,000 -118,551,000 -107,677,000      -14,317,000 -13,142,000 -14,052,000 -17,017,000 -7,504,000 -9,628,000 -14,169,000 -12,216,000 -8,964,000 -8,940,000 -21,704,000 -8,452,000 -7,108,000 -2,295,000 -15,067,000 -893,000 1,819,000 -53,206,000 -12,757,000 -21,662,000 -8,061,000 -7,249,000 -9,726,000 -8,790,000 -14,601,000 -10,677,000 -11,368,000 -6,829,000 -5,344,000 -6,322,000 -7,062,000 
      other comprehensive loss:
    		                                                                       
      foreign currency translation loss
    		  -4,084,000                                                                     
      total other comprehensive loss
    		  -2,999,000                                                                     
      net income per common share - basic
    		   -382.5 -870   -607.5 1,180                                                               
      net income per common share - diluted
    		   -382.5 -870   -607.5 1,150                                                               
      weighted-average common shares - basic
    		    128,590,000                                                                   
      weighted-average common shares - diluted
    		    128,590,000                                                                   
      net income per common share - basic and diluted
    		     -130 -520   -2,210 -1,400 -1,905 -3,320 -2,290 -2,000 -1,260 -1,720 -1,610 -1,710 -1,342.5 -2,180 -1,560 -1,620 -1,407.5 -1,920 -2,020 -1,730 -1,370 -2,430 -1,630 -1,410 -982.5 -1,340 -1,340 -1,250                 -190                    
      loss on the extinguishment of debt
    		            -76,586,000                                                           
      (benefit from) benefit from income taxes
    		       -1,635,500 -2,988,000                                    -21,750 -298,000                          
      weighted-average common shares- basic
    		        125,220,000                                                               
      weighted-average common shares- diluted
    		        131,337,000                                                               
      unrealized loss on marketable securities
    		           -2,751,000 -2,053,000 -1,734,000 -7,217,000                                        -1,808,000     -71,000    -1,000 -39,000 9,000  -31,000    
      cost of collaborations
    		                  8,039,000                                                     
      change in fair value of liability obligation
    		                         9,422,000                                              
      benefit for income taxes
    		                   -685,000 -839,000   -315,250 394,000  -695,000                                             
      unrealized gain on marketable debt securities
    		                   192,000 -1,481,000 -1,796,000 4,045,000                                                 
      foreign currency translation
    		                     571,000 340,000 570,250 1,439,000 842,000                     -29,000  -4,000 -4,000 -23,000 -90,000 109,000 433,000 -499,000 10,000                
      product revenues
    		                       27,647,000 46,066,000 38,231,000 26,291,000 12,075,000 460,000                                           
      net revenue from collaborators
    		                       9,370,250 23,995,000 6,483,000 7,003,000                                             
      costs and expenses:
    		                                                                       
      total costs and expenses
    		                       197,356,750 286,360,000 280,985,000 222,082,000 241,389,000 256,627,000                                12,364,750 16,815,000 17,130,000 15,514,000 16,469,000 12,083,000 12,312,000 8,324,000    
      gain on litigation settlement
    		                             20,564,000                                          
      comprehensive loss:
    		                                                                       
      unrealized gain on marketable securities, net of tax
    		                       193,000 -50,000 462,000 360,000 179,000 415,000 1,046,000  -548,500 218,000                                       
      defined benefit pension plans
    		                       691,000 71,000                                               
      unrealized loss on pension obligation
    		                         -4,282,000                                              
      net revenues from collaborators
    		                           8,958,000 1,609,000 29,907,000 21,899,000 37,924,000 17,096,000 15,932,000 18,960,000                                     
      reclassification adjustment for realized loss on marketable securities included in net income
    		                                                                       
      operating expenses:
    		                                                                       
      general and administrative
    		                             84,679,000 72,447,000 67,455,000 47,644,000 45,779,000 38,487,000      10,672,000 8,955,000 8,429,000 10,224,000 7,522,000 8,928,000 10,107,000 11,170,000 13,120,000 10,680,000 8,398,000 7,716,000 7,274,000 6,863,000 7,106,000 5,872,000 5,540,000 8,035,000 5,273,000 4,540,000 4,629,000 3,982,000 4,438,000 3,584,000 3,707,000 4,088,000 3,122,000 2,952,000 2,999,000 2,962,000 2,947,000 
      total operating expenses
    		                             222,261,000 169,304,000 185,227,000 142,896,000 136,406,000 125,471,000      34,041,000 33,229,000 33,732,000 36,573,000 33,602,000 36,396,000 38,243,000 35,870,000 34,695,000 33,899,000 47,013,000 33,037,000 32,217,000 28,968,000 36,664,000 26,149,000 21,124,000 67,653,000 24,086,000 31,211,000            
      unrealized loss on marketable securities, net of tax
    		                              -420,000   -476,000 -1,936,000                                     
      reclassification adjustment for realized gain on marketable securities included in net income
    		                                 345,000 1,549,000                                     
      net revenues from research collaborators
    		                                        20,455,000 20,791,000 20,614,000 20,897,000 21,192,000 27,668,000 26,617,000 24,564,000 26,626,000 24,249,000 24,601,000 25,057,000 24,404,000 25,734,000 23,833,000 22,192,000 18,232,000 16,315,000 9,133,000 7,217,000            
      equity in loss of joint venture
    		                                        -954,000 -467,000 -1,012,000 -1,072,000 -916,000 -1,226,000 -3,919,000 -1,578,000 -1,488,000 -1,136,000 -816,000 -1,470,000 -3,875,000 -2,181,000 -1,605,000 -1,629,000 -936,000 -139,000              
      non-cash stock-based compensation expenses included in operating expenses are as follows:
    		                                                                       
      weighted-average common shares — basic and diluted
    		                                                         39,025,000 37,534,000 37,376,000            
      foreign currency translation adjustments
    		                                                        -151,250 -687,000 28,000 54,000 69,000 47,000 158,000 71,000 -71,000 -8,000 -256,000 -198,000 412,000 94,000 -106,000 
      non-cash stock-based compensation expense included in these amounts are as follows:
    		                                                                       
      net revenues
    		                                                            4,987,250 8,211,000 6,021,000 5,717,000 1,041,000 1,413,000 1,108,000 1,643,000    
      cost and expenses:
    		                                                                       
      total non-cash stock-based compensation
    		                                                               2,375,000 1,002,000 2,196,000 919,000 480,000    
      accretion of redeemable convertible preferred stock
    		                                                                      -751,000 
      net income attributable to common stockholders
    		                                                                -14,491,000 -10,678,000 -11,145,000 -6,600,000 -5,700,000 -6,416,000 -7,707,000 
      revenue from research collaborators
    		                                                                    408,000 1,367,000 131,000 
      in-process research and development
    		                                                                       
      net income per common share
    		                                                                    -785 -330 -1,100 
      noncash stock-based compensation expense included in these amounts are as follows:
    		                                                                       
      total stock-based compensation
    		                                                                    728,750 731,000 -47,000 
      costs and expenses
    		                                                                       
      noncash stock-based compensation income included in these amounts are as follows:
    		                                                                       
    The information provided in this report is taken from www.sec.gov and many other data providers. While we have conducted our best efforts to ensure that the parsed data is accurate, we cannot guarantee its accuracy. Please use caution and understand that any consequences of its use are your own responsibility.