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Alnylam Pharmaceuticals Quarterly Balance Sheets Chart

Quarterly
 | 
Annual
 
 Account Receivables  
 Cash and Cash Eq  
 Account Payables  
 Deferred Revenue  
 Long-Term Debt  
 Inventory  
20200930 20201231 20210331 20210630 20210930 20211231 20220331 20220630 20220930 20221231 20230331 20230630 20230930 20231231 20240331 20240630 20240930 20241231 20250331 20250630 00.160.320.480.640.80.951.11Billion

Alnylam Pharmaceuticals Quarterly Balance Sheets Table

Quarterly
 | 
Annual
 
Unit: USD2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 2009-12-31 2009-09-30 2009-06-30 2009-03-31 2008-12-31 2008-09-30 2008-06-30 2008-03-31 2007-12-31 2007-09-30 2007-06-30 2007-03-31 2006-12-31 2006-09-30 2006-06-30 2006-03-31 2005-12-31 2005-09-30 2005-06-30 2005-03-31 2004-12-31 2004-09-30 2004-06-30 
                                                                                       
  assets                                                                                     
  current assets:                                                                                     
  cash and cash equivalents1,113,685,000 1,019,654,000 966,428,000 1,099,920,000 968,492,000 681,879,000 812,688,000 1,033,024,000 657,800,000 672,245,000 866,394,000 1,073,228,000 575,558,000 534,081,000 819,975,000 1,093,991,000 745,767,000 379,543,000 496,580,000 496,704,000 580,829,000 467,779,000 547,178,000 923,304,000 1,136,289,000 724,959,000 420,146,000 316,608,000 361,457,000 396,149,000 645,361,000 202,045,000 408,671,000 171,079,000 193,617,000 168,481,000 271,076,000 231,278,000 180,895,000 149,218,000 151,262,000 306,580,000 75,179,000 82,721,000 80,727,000 350,589,000 53,169,000 11,840,000 24,975,000 97,804,000 51,405,000 75,838,000 48,274,000 61,739,000 70,228,000 74,336,000 67,110,000 90,590,000 74,599,000 46,881,000 66,182,000 114,947,000 137,468,000 98,087,000 147,870,000 227,268,000 191,792,000 196,737,000 247,536,000 196,281,000 105,157,000 200,547,000 84,464,000 66,662,000 127,955,000 35,516,000 35,645,000 56,804,000 15,757,000 7,178,000 9,165,000 12,215,000 20,272,000 14,544,000 31,891,000 
  marketable debt securities1,743,900,000 1,605,368,000 1,719,920,000 1,671,993,000 1,646,268,000 1,678,147,000 1,615,516,000 1,362,843,000 1,372,451,000 1,372,574,000 1,297,890,000 1,169,050,000 1,504,154,000 1,673,485,000 1,548,617,000 1,161,324,000 1,101,782,000 1,273,027,000 1,333,182,000 1,279,955,000 1,258,425,000 836,346,000 975,017,000 797,754,000 790,542,000 519,578,000 662,803,000 905,222,000 1,074,165,000                                                         
  marketable equity securities 7,200,000 8,156,000 8,322,000 9,889,000 11,256,000 11,178,000 10,411,000 27,256,000 25,856,000 28,122,000 23,051,000 30,901,000 31,997,000 66,972,000 72,550,000 52,533,000 56,967,000 44,633,000 57,217,000 86,310,000 38,078,000 13,967,000    1,206,000 15,004,000 12,044,000                                                         
  accounts receivable567,112,000 418,035,000 405,308,000 353,852,000 309,481,000 321,377,000 327,787,000 325,445,000 220,635,000 219,434,000 237,963,000 184,513,000 142,271,000 156,533,000 198,571,000 141,064,000 146,587,000 110,626,000 102,413,000 79,118,000 69,115,000 75,572,000 43,011,000 48,109,000 30,739,000 33,801,000 18,760,000 3,362,000                                                          
  inventory71,688,000 65,581,000 78,509,000 75,987,000 83,981,000 93,988,000 89,146,000 95,771,000 100,453,000 131,879,000 128,962,000 115,489,000 88,976,000 78,516,000 86,363,000 97,899,000 84,358,000 73,940,000 75,202,000 66,942,000 77,418,000 68,300,000 56,348,000 54,562,000 40,587,000 32,001,000 24,068,000 11,081,000                                                          
  prepaid expenses and other current assets147,314,000 152,420,000 116,964,000 145,350,000 154,745,000 201,960,000 126,382,000 157,958,000 145,452,000 119,030,000 132,916,000 125,516,000 129,778,000 115,065,000 88,078,000 108,534,000 94,136,000 75,980,000 62,767,000 74,766,000 88,349,000 98,698,000 80,343,000 73,536,000 65,616,000 81,674,000 73,713,000 90,843,000 51,932,000 66,665,000 40,120,000 30,430,000 22,033,000 18,127,000 21,744,000 19,282,000 22,152,000 27,626,000 16,559,000 17,453,000 15,117,000 13,206,000 9,739,000 10,699,000 10,270,000 8,409,000 3,910,000 4,776,000 4,205,000 3,542,000 2,540,000 5,679,000 6,933,000 7,252,000 4,158,000 4,909,000 5,077,000 4,919,000 6,889,000 6,432,000 6,021,000 5,109,000 4,151,000 5,173,000 5,327,000 5,454,000 4,674,000 4,523,000 4,182,000 1,922,000 2,926,000 4,125,000 1,575,000 1,057,000 1,695,000 1,706,000 2,199,000 1,729,000 1,657,000 1,301,000 1,238,000 988,000 966,000 1,345,000 1,413,000 
  total current assets3,643,699,000 3,268,258,000 3,295,285,000 3,355,424,000 3,172,856,000 2,988,607,000 2,982,697,000 2,985,452,000 2,524,047,000 2,541,018,000 2,692,247,000 2,690,847,000 2,471,638,000 2,589,677,000 2,808,576,000 2,675,362,000 2,725,163,000 2,470,083,000 2,614,777,000 2,554,702,000 2,160,446,000 1,584,773,000 1,715,864,000 1,897,265,000 2,063,773,000 1,392,013,000 1,200,696,000 1,342,120,000 1,502,559,000 1,685,297,000 1,764,740,000 993,368,000 960,709,000 597,188,000 671,877,000 747,564,000 888,068,000 1,050,074,000 1,105,388,000 1,041,793,000 1,029,150,000 1,090,186,000 746,367,000 643,017,000 665,121,000 674,063,000 254,028,000 199,164,000 214,359,000 240,111,000 125,456,000 235,933,000 240,342,000 208,539,000 152,028,000 179,957,000 224,334,000 250,709,000 254,139,000 244,623,000 273,510,000 273,309,000 293,534,000 228,165,000 278,422,000 419,339,000 442,249,000 451,779,000 550,631,000 455,475,000 463,559,000 477,632,000 201,958,000 209,916,000 222,784,000 126,827,000 129,057,000 137,120,000 82,414,000 26,697,000 33,840,000 41,442,000  47,198,000 50,511,000 
  property, plant and equipment499,791,000 498,684,000 502,784,000 506,997,000 517,159,000 523,460,000 526,057,000 525,591,000 527,474,000 523,032,000 523,494,000 514,821,000 508,201,000 504,389,000 501,958,000 484,941,000 470,700,000 464,572,000 465,029,000 444,690,000 439,126,000 429,814,000 425,179,000 396,456,000 371,769,000 341,712,000 320,658,000 272,652,000 227,839,000 201,979,000 181,900,000 161,899,000 147,533,000 129,962,000 114,572,000                                                   
  operating lease right-of-use assets192,401,000 197,233,000 191,148,000 196,408,000 198,303,000 195,468,000 199,732,000 203,485,000 208,801,000 215,049,000 215,136,000 218,802,000 223,921,000 228,769,000 231,675,000 235,853,000 238,089,000 237,213,000 241,485,000 245,234,000 229,674,000 221,280,000 221,197,000 223,444,000 226,357,000 226,412,000                                                            
  deferred tax assets104,363,000 107,224,000 116,863,000                                     9,406,000 19,654,000 33,667,000 31,667,000                 1,943,000 1,937,000 1,937,000 1,937,000 5,312,000 5,606,000 5,606,000 5,382,000                   
  restricted investments68,593,000 68,592,000 68,593,000 68,592,000 49,391,000 49,390,000 49,391,000 49,390,000 49,388,000 49,388,000 49,390,000 49,389,000 49,390,000 40,889,000 40,891,000 40,890,000 40,890,000 40,725,000 40,725,000 24,725,000 24,725,000 24,725,000 14,825,000 14,825,000 44,825,000 44,825,000 44,825,000 44,825,000 44,825,000 30,000,000 30,000,000 150,000,000 150,000,000 150,000,000 150,000,000 150,000,000 150,000,000                                                 
  other assets57,172,000 73,820,000 65,310,000 77,618,000 71,925,000 67,461,000 72,003,000 75,155,000 92,686,000 63,453,000 66,092,000 61,396,000 77,267,000 69,821,000 60,204,000 35,267,000 34,587,000 42,676,000 45,045,000 37,932,000 20,396,000 19,032,000 18,069,000 9,632,000 9,687,000 9,037,000 8,623,000 16,057,000 14,166,000 5,215,000 4,171,000 1,471,000 1,471,000 1,471,000 1,562,000 1,561,000 1,471,000 1,471,000 1,471,000            101,000                 89,000 116,000 145,000 173,000 201,000 685,000 749,000 803,000 351,000 416,000 508,000 550,000 428,000 457,000 485,000 514,000   
  total assets4,566,019,000 4,213,811,000 4,239,983,000 4,205,039,000 4,009,634,000 3,824,386,000 3,829,880,000 3,839,073,000 3,402,396,000 3,391,940,000 3,546,359,000 3,535,255,000 3,330,417,000 3,433,545,000 3,643,304,000 3,472,313,000 3,509,429,000 3,255,269,000 3,407,061,000 3,307,283,000 3,374,367,000 2,279,624,000 2,395,134,000 2,541,622,000 2,716,411,000 2,013,999,000 1,574,802,000 1,675,654,000 1,789,389,000 1,923,139,000 1,994,730,000 1,358,281,000 1,434,283,000 1,133,926,000 1,262,810,000 1,312,910,000 1,382,162,000 1,316,949,000 1,386,510,000 1,436,144,000 1,530,771,000 1,628,790,000 1,079,595,000 986,357,000 1,032,659,000 1,080,297,000 420,530,000 447,503,000 462,558,000 471,578,000 287,520,000 322,352,000 318,477,000 340,295,000 281,917,000 310,223,000 340,828,000 369,052,000 393,265,000 412,606,000 440,180,000 463,406,000 481,385,000 495,668,000 518,653,000 554,529,000 554,676,000 580,181,000 580,046,000 486,256,000 493,791,000 505,091,000 219,658,000 227,340,000 240,006,000 144,527,000 147,114,000 153,687,000 98,348,000 43,248,000 50,862,000 59,067,000  62,545,000 68,473,000 
  liabilities and stockholders' equity                                                                                     
  current liabilities:                                                                                     
  accounts payable102,393,000 97,399,000 88,415,000 70,805,000 73,980,000 78,148,000 55,519,000 73,840,000 59,746,000 62,237,000 98,094,000 40,572,000 52,418,000 54,916,000 73,426,000 40,048,000 53,079,000 45,381,000 51,966,000 27,872,000 26,125,000 40,484,000 49,884,000 39,392,000 71,215,000 22,671,000 59,708,000 21,772,000 11,988,000 13,206,000 28,355,000 9,239,000 23,170,000 25,371,000 54,465,000 23,137,000 12,824,000 17,442,000 16,787,000 14,272,000 15,715,000 15,486,000 15,111,000 5,201,000 6,168,000 5,037,000 5,896,000 2,728,000 4,534,000 3,105,000 4,420,000 5,093,000 5,519,000 4,339,000 5,800,000 5,486,000 7,949,000 5,800,000 9,312,000 6,561,000 10,398,000 6,988,000 12,489,000 8,426,000 6,463,000 8,729,000 2,588,000 3,342,000 6,240,000 9,084,000 3,826,000 7,057,000 5,669,000 3,007,000 4,085,000 2,456,000 3,698,000 3,928,000 1,975,000 1,985,000 1,612,000 1,653,000 910,000 1,450,000 1,810,000 
  accrued expenses918,966,000 704,165,000 887,472,000 946,168,000 808,643,000 698,865,000 713,013,000 713,094,000 598,530,000 508,599,000 545,460,000 510,579,000 421,243,000 355,936,000 395,174,000 388,576,000 341,187,000 280,527,000 355,909,000 295,260,000 211,186,000 183,221,000 197,201,000 177,948,000 138,800,000 106,873,000 112,719,000 93,564,000 89,867,000 63,824,000 72,203,000 51,260,000 43,820,000 31,842,000 42,118,000 36,211,000 37,551,000 30,805,000 28,798,000 18,444,000 17,758,000 14,427,000 23,680,000 19,799,000 15,783,000 16,600,000 14,160,000 15,386,000 8,488,000 9,086,000 11,558,000 14,914,000 14,228,000 13,006,000 12,340,000 12,230,000 11,380,000 12,050,000 11,116,000 10,880,000 7,425,000 8,754,000 9,833,000 8,381,000 9,908,000 10,389,000 9,328,000 9,859,000 9,497,000 9,666,000 11,724,000 11,746,000 9,980,000 7,297,000 4,479,000 5,104,000 4,583,000 3,669,000 3,899,000       
  operating lease liabilities46,097,000 46,011,000 41,886,000                                                                                   
  deferred revenue15,080,000 28,160,000 55,481,000 71,030,000 69,009,000 76,850,000 102,753,000 77,140,000 54,639,000 35,794,000 42,105,000 144,208,000 114,292,000 131,838,000 149,483,000 115,044,000 98,144,000 116,340,000 127,207,000 114,601,000 107,587,000 86,043,000 77,821,000 107,359,000 89,242,000 2,642,000 3,496,000 3,444,000 9,161,000 35,855,000 41,705,000 38,532,000 39,794,000 36,755,000 33,540,000 21,087,000 18,885,000 16,944,000 15,352,000 13,973,000 12,460,000 14,099,000 23,871,000 30,270,000 27,002,000 29,121,000 32,696,000 33,558,000 33,560,000 33,548,000 31,417,000 31,156,000 35,345,000 48,410,000 62,366,000 75,727,000 80,721,000 81,010,000 81,134,000 81,270,000 83,100,000 81,893,000 81,929,000 82,420,000 82,570,000 82,539,000 79,864,000 80,048,000 80,806,000 58,822,000 59,249,000 61,652,000 7,840,000 9,899,000 11,144,000 10,924,000 9,599,000 10,387,000 10,734,000 1,266,000 1,390,000 1,519,000 1,000,000 1,071,000 1,451,000 
  liability related to the sale of future royalties97,523,000 81,793,000 113,018,000 90,516,000 61,963,000 46,174,000 54,991,000 44,195,000 33,650,000 23,706,000 40,289,000 35,851,000 28,496,000 21,983,000 37,079,000 26,376,000 22,876,000 13,660,000 13,316,000 10,316,000 5,957,000                                                                 
  development derivative liability120,788,000 118,095,000                                                                                    
  total current liabilities1,300,847,000 1,075,623,000 1,186,272,000 1,220,663,000 1,055,251,000 941,709,000 967,786,000 949,785,000 788,639,000 673,391,000 767,915,000 772,791,000 657,685,000 605,963,000 695,710,000 610,656,000 554,648,000 494,825,000 585,270,000 480,241,000 384,302,000 338,791,000 352,594,000 352,864,000 328,604,000 149,163,000 179,494,000 121,503,000 113,659,000 115,383,000 144,251,000 101,045,000 108,726,000 95,786,000 131,699,000 81,761,000 70,575,000 66,369,000 62,099,000 57,112,000 66,598,000 80,693,000 95,334,000 56,849,000 53,745,000 83,831,000 53,864,000 54,895,000 53,066,000 49,750,000 48,345,000 54,758,000 57,064,000 66,638,000 80,990,000 93,927,000 100,534,000 99,344,000 102,046,000 99,433,000 102,033,000 98,571,000 110,733,000 101,121,000 102,331,000 104,251,000 99,452,000 102,024,000 105,727,000 84,910,000 82,091,000 87,456,000 27,106,000 23,498,000 22,925,000 21,530,000 20,601,000 19,990,000 18,484,000 8,002,000 9,021,000 6,138,000  6,640,000 8,704,000 
  operating lease liabilities, net of current portion224,445,000 230,061,000 229,541,000                                                                                   
  convertible debt1,026,522,000 1,025,566,000 1,024,621,000 1,023,654,000 1,022,688,000 1,021,732,000 1,020,776,000 1,019,809,000 1,018,843,000 1,017,887,000 1,016,942,000 1,015,975,000                                                                          
  liability related to the sale of future royalties, net of current portion1,345,147,000 1,338,821,000 1,334,353,000 1,333,849,000 1,342,580,000 1,336,892,000 1,322,248,000 1,310,814,000 1,298,446,000 1,285,200,000 1,252,015,000 1,231,873,000 1,214,311,000 1,193,822,000 1,151,024,000 1,132,362,000 1,105,685,000 1,086,065,000 1,058,225,000 1,032,708,000 1,008,336,000                                                                 
  development derivative liability, net of current portion407,535,000 422,434,000                                                                                    
  other liabilities10,932,000 5,871,000 398,108,000 357,477,000 350,428,000 319,990,000 308,438,000 280,734,000 257,054,000 224,046,000 212,580,000 183,001,000 157,301,000 120,828,000 98,963,000 76,450,000 71,633,000 60,461,000 37,908,000 16,341,000 18,855,000 9,198,000 9,330,000 9,036,000 9,514,000 5,072,000 4,965,000 4,335,000 4,186,000 4,458,000 4,347,000 2,842,000 2,815,000 3,184,000 3,067,000 1,991,000 1,777,000 1,373,000 1,301,000     500,000 1,000,000 1,000,000                                        
  total liabilities4,315,428,000 4,098,376,000 4,172,895,000 4,172,685,000 4,012,701,000 4,043,658,000 4,050,524,000 4,004,939,000 3,810,527,000 3,651,180,000 3,704,582,000 3,602,893,000 3,154,377,000 3,032,379,000 3,055,101,000 2,716,420,000 2,656,067,000 2,329,079,000 2,390,814,000 2,092,260,000 1,974,641,000 929,895,000 956,442,000 934,535,000 959,216,000 467,013,000 272,837,000 197,535,000 168,587,000 168,334,000 228,299,000 299,446,000 311,317,000 303,025,000 342,589,000 297,942,000 283,680,000 127,898,000 121,796,000 114,540,000 122,167,000 132,280,000 143,328,000 81,879,000 90,390,000 125,324,000 150,183,000 149,921,000 154,383,000 160,022,000 153,467,000 145,192,000 130,190,000 142,917,000 163,920,000 182,350,000 204,277,000 223,485,000 235,032,000 251,963,000 274,702,000 291,576,000 303,420,000 313,647,000 334,171,000 355,785,000 352,551,000 375,624,000 380,877,000 283,444,000 294,623,000 312,156,000 40,388,000 37,313,000 38,832,000 39,750,000 37,037,000 35,771,000 36,569,000 20,177,000 21,474,000 19,238,000  17,564,000 17,798,000 
  commitments and contingencies                                                                                     
  stockholders' equity:                                                                                     
  preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of june 30, 2025 and december 31, 2024                                                                                     
  common stock1,310,000 1,303,000 1,293,000 1,289,000 1,281,000 1,265,000 1,259,000 1,255,000 1,250,000 1,243,000 1,240,000 1,230,000 1,210,000 1,207,000 1,202,000 1,195,000 1,186,000 1,173,000 1,164,000 1,161,000 1,156,000 1,131,000 1,122,000 1,113,000 1,110,000 1,064,000 1,011,000 1,009,000 1,005,000 1,005,000 997,000 924,000 917,000 861,000 859,000 858,000 856,000 855,000 851,000 847,000 845,000 842,000 772,000 767,000 763,000 755,000 637,000 632,000 624,000 621,000 525,000 524,000 520,000 519,000 427,000 427,000 427,000 424,000 423,000 422,000 421,000 419,000 418,000 418,000 417,000 414,000 414,000 414,000 411,000 408,000 408,000 406,000 376,000 375,000 371,000 322,000 321,000 320,000 267,000 212,000 209,000 209,000  201,000 200,000 
  additional paid-in capital7,690,737,000 7,496,876,000 7,388,061,000 7,259,876,000 7,122,704,000 6,881,977,000 6,811,063,000 6,736,939,000 6,647,173,000 6,522,091,000 6,454,540,000 6,336,771,000 6,172,990,000 6,116,558,000 6,058,453,000 5,968,661,000 5,863,476,000 5,747,394,000 5,644,074,000 5,592,884,000 5,520,320,000 5,289,966,000 5,201,176,000 5,091,248,000 5,034,284,000 4,601,662,000 4,175,139,000 4,140,033,000 4,037,853,000 4,009,342,000 3,947,552,000 3,097,110,000 3,038,529,000 2,627,969,000 2,609,614,000 2,585,765,000 2,565,728,000 2,546,884,000 2,506,197,000 2,483,958,000 2,468,187,000 2,450,690,000 1,843,362,000 1,823,766,000 1,810,775,000 1,776,366,000 846,228,000 833,660,000 813,613,000 806,137,000 624,876,000 621,350,000 613,149,000 609,260,000 518,731,000 514,290,000 509,826,000 504,793,000 500,443,000 495,350,000 490,558,000 482,743,000 476,663,000 471,755,000 465,277,000 457,838,000 452,767,000 448,092,000 440,410,000 428,990,000 424,453,000 420,039,000 353,221,000 351,252,000 340,779,000 236,416,000 235,264,000 234,057,000 170,033,000 117,176,000 112,902,000 112,158,000 112,216,000 106,403,000 107,526,000 
  accumulated other comprehensive loss-29,952,000 -37,517,000 -34,518,000 -24,826,000 -34,637,000 -26,988,000 -23,375,000 -32,339,000 -37,080,000 -39,124,000 -44,654,000 -43,783,000 -42,224,000 -38,065,000 -33,259,000 -34,230,000 -36,081,000 -36,717,000 -43,622,000 -37,193,000 -33,212,000 -32,059,000 -36,518,000 -34,371,000 -35,831,000 -32,853,000 -33,213,000 -33,392,000 -33,807,000 -34,853,000 -34,433,000 -33,741,000 -33,959,000 -33,828,000                   -62,000 -37,000                        -71,000        
  accumulated deficit-7,411,504,000 -7,345,227,000 -7,287,748,000 -7,203,985,000 -7,092,415,000 -7,075,526,000 -7,009,591,000 -6,871,721,000 -7,019,474,000 -6,743,450,000 -6,569,349,000 -6,361,856,000 -5,955,936,000 -5,678,534,000 -5,438,193,000 -5,179,733,000 -4,975,219,000 -4,785,660,000 -4,585,369,000 -4,341,829,000 -4,088,538,000 -3,909,309,000 -3,727,088,000 -3,450,903,000 -3,242,368,000 -3,022,887,000 -2,840,972,000 -2,629,531,000 -2,384,249,000 -2,220,689,000 -2,147,685,000 -2,005,458,000 -1,882,521,000 -1,764,101,000 -1,656,811,000 -1,543,877,000 -1,439,806,000 -1,349,677,000 -1,246,703,000 -1,155,982,000 -1,079,190,000 -1,007,407,000 -956,630,000 -935,241,000 -891,252,000 -847,178,000 -596,235,000 -563,878,000 -534,192,000 -516,023,000 -507,010,000 -444,822,000 -425,320,000 -412,364,000 -400,996,000 -386,693,000 -373,456,000 -359,632,000 -343,347,000 -336,417,000 -326,787,000 -312,155,000 -299,832,000 -292,041,000 -282,833,000 -260,131,000 -252,242,000 -242,850,000 -239,992,000 -227,232,000 -225,993,000 -227,655,000 -174,863,000 -162,171,000 -140,527,000 -132,089,000 -124,689,000 -114,779,000 -105,919,000 -91,428,000 -80,750,000 -69,604,000 -63,005,000 -57,305,000 -50,889,000 
  total stockholders' equity250,591,000 115,435,000                                                                                    
  total liabilities and stockholders' equity4,566,019,000 4,213,811,000                                                                                    
  preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of march 31, 2025 and december 31, 2024                                                                                     
  liabilities and stockholders’ equity                                                                                     
  deferred revenue, net of current portion   1,012,000 2,402,000 185,506,000 188,175,000 196,086,000 194,129,000 191,257,000 193,791,000 132,930,000 175,341,000 157,668,000 152,360,000 177,123,000 202,391,000 208,123,000 225,094,000 265,708,000 281,530,000 306,124,000 318,383,000 296,179,000 313,887,000 478,000 458,000 1,623,000 4,522,000 7,676,000 43,075,000 38,356,000 42,079,000 46,049,000 49,392,000 55,894,000 54,810,000 53,952,000 52,965,000 52,117,000 50,256,000 46,566,000 42,983,000 20,028,000 32,548,000 37,674,000 93,394,000 91,779,000 97,636,000 105,980,000 100,874,000 85,029,000 68,108,000 72,374,000 78,487,000 84,810,000 100,122,000 120,200,000 129,974,000 149,666,000 169,958,000 190,248,000 189,884,000 209,677,000 229,669,000 248,959,000 250,121,000 269,441,000 268,868,000 191,440,000 204,067,000 217,051,000 5,105,000 5,655,000 6,786,000 8,473,000 6,685,000 8,070,000 10,099,000       
  stockholders’ equity                                                                                     
  preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of december 31, 2024 and december 31, 2023                                                                                     
  total stockholders’ equity  67,088,000 32,354,000         176,040,000 401,166,000 588,203,000 755,893,000 853,362,000 926,190,000 1,016,247,000 1,215,023,000 1,399,726,000 1,349,729,000 1,438,692,000 1,607,087,000 1,757,195,000 1,546,986,000 1,301,965,000 1,478,119,000 1,620,802,000 1,754,805,000 1,766,431,000 1,058,835,000 1,122,966,000 830,901,000 920,221,000 1,014,968,000 1,098,482,000 1,189,051,000 1,264,714,000 1,321,604,000 1,408,604,000 1,496,510,000 936,267,000 904,478,000 942,269,000 954,973,000 270,347,000 297,582,000 308,175,000 311,556,000 134,053,000 177,160,000 188,287,000 197,378,000 117,997,000 127,873,000 136,551,000 145,567,000 158,233,000 160,643,000 165,478,000 171,830,000 177,965,000 182,021,000 184,482,000 198,744,000 202,125,000 204,557,000 199,169,000 202,812,000 199,168,000 192,935,000 179,270,000 190,027,000 201,174,000 104,777,000 110,077,000 117,916,000 61,779,000 23,071,000 29,388,000 39,829,000  44,981,000 50,675,000 
  total liabilities and stockholders’ equity  4,239,983,000 4,205,039,000         3,330,417,000 3,433,545,000 3,643,304,000 3,472,313,000 3,509,429,000 3,255,269,000 3,407,061,000 3,307,283,000 3,374,367,000 2,279,624,000 2,395,134,000 2,541,622,000 2,716,411,000 2,013,999,000 1,574,802,000 1,675,654,000 1,789,389,000 1,923,139,000 1,994,730,000 1,358,281,000 1,434,283,000 1,133,926,000 1,262,810,000 1,312,910,000 1,382,162,000 1,316,949,000 1,386,510,000 1,436,144,000 1,530,771,000 1,628,790,000 1,079,595,000 986,357,000 1,032,659,000 1,080,297,000 420,530,000 447,503,000 462,558,000 471,578,000 287,520,000 322,352,000 318,477,000 340,295,000 281,917,000 310,223,000 340,828,000 369,052,000 393,265,000 412,606,000 440,180,000 463,406,000 481,385,000 495,668,000 518,653,000 554,529,000 554,676,000 580,181,000 580,046,000 486,256,000 493,791,000 505,091,000 219,658,000 227,340,000 240,006,000 144,527,000 147,114,000 153,687,000 98,348,000 43,248,000 50,862,000 59,067,000    
  operating lease liability   42,144,000 41,656,000 41,672,000 41,510,000 41,516,000 42,074,000 43,055,000 41,967,000 41,581,000 41,236,000 41,290,000 40,548,000 40,612,000 39,362,000 38,917,000 36,872,000 32,192,000 33,447,000 29,043,000 27,688,000 28,165,000 29,347,000 16,977,000                                                            
  operating lease liability, net of current portion   236,030,000 239,352,000 237,829,000 243,101,000 247,711,000 253,416,000 259,399,000 261,339,000 266,323,000 272,016,000 277,388,000 281,347,000 286,030,000 288,559,000 288,015,000 293,039,000 297,262,000 281,618,000 275,782,000 276,135,000 276,456,000 277,211,000 282,300,000                                                            
  preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of september 30, 2024 and december 31, 2023                                                                                     
  liabilities and stockholders’ deficit                                                                                     
  stockholders’ deficit:                                                                                     
  preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of june 30, 2024 and december 31, 2023                                                                                     
  total stockholders’ deficit    -3,067,000 -219,272,000 -220,644,000 -165,866,000 -408,131,000 -259,240,000                                                                            
  total liabilities and stockholders’ deficit    4,009,634,000 3,824,386,000 3,829,880,000 3,839,073,000 3,402,396,000 3,391,940,000                                                                            
  preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of march 31, 2024 and december 31, 2023                                                                                     
  preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of december 31, 2023 and december 31, 2022                                                                                     
  preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of september 30, 2023 and december 31, 2022                                                                                     
  preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of june 30, 2023 and december 31, 2022                                                                                     
  preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of march 31, 2023 and december 31, 2022                                                                                     
  liabilities and stockholders’ (deficit) equity                                                                                     
  long-term debt            677,723,000 676,710,000 675,697,000 433,799,000 433,151,000 191,590,000 191,278,000      30,000,000 30,000,000 30,000,000 30,000,000 30,000,000 30,000,000 30,000,000 150,000,000 150,000,000 150,000,000 150,000,000 150,000,000 150,000,000                                                 
  stockholders’ (deficit) equity:                                                                                     
  preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of december 31, 2022 and december 31, 2021                                                                                     
  total stockholders’ (deficit) equity          -158,223,000 -67,638,000                                                                          
  total liabilities and stockholders’ (deficit) equity          3,546,359,000 3,535,255,000                                                                          
  preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of september 30, 2022 and december 31, 2021                                                                                     
  stockholders’ equity:                                                                                     
  preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of june 30, 2022 and december 31, 2021                                                                                     
  preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of march 31, 2022 and december 31, 2021                                                                                     
  receivable related to the sale of future royalties                500,000,000 500,000,000 500,000,000 500,000,000 500,000,000                                                                 
  preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of december 31, 2021 and december 31, 2020                                                                                     
  preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of september 30, 2021 and december 31, 2020                                                                                     
  preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of june 30, 2021 and december 31, 2020                                                                                     
  preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of march 31, 2021 and december 31, 2020                                                                                     
  preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of december 31, 2020 and december 31, 2019                                                                                     
  preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of september 30, 2020 and december 31, 2019                                                                                     
  preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of june 30, 2020 and december 31, 2019                                                                                     
  preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of march 31, 2020 and december 31, 2019                                                                                     
  deferred rent                          3,571,000 2,723,000 2,643,000 2,498,000 1,988,000 2,014,000 1,942,000 1,818,000 1,576,000 1,326,000 1,315,000 1,178,000 1,162,000 1,017,000 1,011,000 1,010,000 1,005,000 723,000 711,000 869,000 1,112,000 1,200,000 1,252,000 988,000 950,000 840,000 608,000 608,000 484,000 484,000 484,000 484,000 484,000 485,000 838,000 838,000 838,000 837,000 1,561,000 1,561,000 1,561,000 1,561,000 5,074,000 4,853,000 5,200,000 3,120,000 3,271,000 3,095,000 3,202,000 3,310,000 3,417,000 2,391,000 2,467,000 2,574,000 2,682,000 2,789,000 2,896,000   
  deferred rent, net of current portion                          57,920,000 40,074,000 16,220,000 10,817,000 6,626,000 7,203,000 7,697,000 8,006,000 8,431,000 8,296,000 6,518,000 6,204,000 5,431,000 5,311,000 5,313,000 5,021,000 5,011,000 4,502,000 3,097,000 2,819,000 2,925,000 3,247,000 3,681,000 4,292,000 4,248,000 4,884,000 4,328,000 3,202,000 3,727,000 2,884,000 2,879,000 2,874,000 2,869,000 2,864,000 2,543,000 2,576,000 2,609,000 2,642,000 1,951,000 2,342,000 2,732,000 3,122,000                  
  preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of december 31, 2019 and december 31, 2018                                                                                     
  preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of september 30, 2019 and december 31, 2018                                                                                     
  preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding at june 30, 2019 and december 31, 2018                                                                                     
  preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding at march 31, 2019 and december 31, 2018                                                                                     
  preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at december 31, 2018 and 2017                                                                                     
  preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at september 30, 2018 and december 31, 2017                                                                                     
  billed and unbilled collaboration receivables                            2,961,000 50,768,000 34,002,000 14,644,000 15,405,000 19,457,000 23,334,000 15,146,000 9,514,000 8,814,000 8,298,000 8,130,000 9,403,000 10,107,000 39,937,000 384,000 89,000 164,000 4,248,000 609,000 460,000 558,000 104,000 1,918,000 4,385,000 2,192,000 1,468,000                               
  preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at june 30, 2018 and december 31, 2017                                                                                     
  marketable securities                             1,171,715,000 1,045,257,000 746,249,000 514,600,000 385,843,000 424,185,000 531,041,000 571,994,000 748,422,000 848,217,000 828,427,000 788,740,000 660,403,000 526,929,000 507,927,000 524,585,000 314,901,000 192,701,000 181,939,000 184,719,000 138,207,000 71,407,000 152,498,000 180,750,000 137,356,000 76,174,000 98,685,000 150,839,000 154,050,000 158,532,000 184,486,000 193,012,000 146,811,000 143,934,000 119,883,000 119,368,000 180,786,000 238,596,000 223,379,000 290,787,000 247,592,000 350,445,000 267,831,000 110,304,000 137,804,000 89,305,000 84,758,000 87,622,000 75,471,000 64,245,000 17,631,000 22,477,000 26,075,000  30,393,000 14,207,000 
  preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at march 31, 2018 and december 31, 2017                                                                                     
  investment in equity securities of regulus therapeutics inc.                                 2,682,000 8,997,000 13,614,000 13,332,000 33,934,000 51,419,000 38,565,000 64,628,000 99,890,000  41,286,000 49,450,000 55,478,000 45,452,000 57,999,000 60,336,000 47,666,000                                    
  preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at december 31, 2017 and 2016                                                                                     
  preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at september 30, 2017 and december 31, 2016                                                                                     
  preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at june 30, 2017 and december 31, 2016                                                                                     
  preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at march 31, 2017 and december 31, 2016                                                                                     
  preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at december 31, 2016 and 2015                                                                                     
  accumulated other comprehensive income                                  -33,441,000 -27,778,000 -28,296,000 -9,011,000 4,369,000 -7,219,000 18,762,000 52,385,000 48,763,000 15,186,000 21,983,000 25,030,000 19,717,000 27,168,000 28,130,000 20,821,000 15,662,000    -165,000 -151,000 -246,000 -18,000 714,000 1,288,000 1,286,000 823,000 716,000 1,889,000 1,621,000 623,000 1,186,000 -1,099,000 -1,660,000 646,000 300,000 145,000 558,000 624,000 640,000    -142,000 -32,000 -32,000 191,000 420,000 41,000 -37,000 
  property and equipment                                   74,219,000 55,394,000 36,814,000 27,812,000 26,316,000 25,169,000 21,166,000 21,740,000 18,806,000 16,953,000 15,731,000 16,448,000 16,974,000 18,045,000 18,983,000 19,799,000 18,792,000 14,206,000 13,703,000 14,643,000 15,309,000 16,252,000 17,021,000 18,289,000 18,399,000 18,554,000 18,304,000 18,324,000 18,152,000 18,483,000 19,321,000 19,194,000 19,577,000 18,853,000 15,875,000 13,810,000 10,434,000 12,965,000 12,527,000 12,173,000    10,580,000    11,694,000 8,969,000 11,436,000 
  preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at september 30, 2016 and december 31, 2015                                                                                     
  preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at june 30, 2016 and december 31, 2015                                                                                     
  preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at march 31, 2016 and december 31, 2015                                                                                     
  deferred tax liabilities                                       9,406,000 19,654,000 33,667,000 31,667,000                                           
  preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at december 31, 2015 and 2014                                                                                     
  preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at september 30, 2015 and december 31, 2014                                                                                     
  preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at june 30, 2015 and december 31, 2014                                                                                     
  accrued intraperiod tax allocation                                         2,004,000  856,000 4,081,000 6,825,000  2,023,000 5,232,000 3,023,000                                    
  preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at march 31, 2015 and december 31, 2014                                                                                     
  investment in equity securities of regulus therapeutics inc                                          94,583,000        38,748,000                                   
  preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at december 31, 2014 and 2013                                                                                     
  preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at september 30, 2014 and december 31, 2013                                                                                     
  preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at june 30, 2014 and december 31, 2013                                                                                     
  liability for stock issuance                                             25,379,000                                        
  preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at march 31, 2014 and december 31, 2013                                                                                     
  preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at december 31, 2013 and 2012                                                                                     
  preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at september 30, 2013 and december 31, 2012                                                                                     
  preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at june 30, 2013 and december 31, 2012                                                                                     
  preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at march 31, 2013 and december 31, 2012                                                                                     
  other long-term liabilities                                                   521,000 690,000 703,000 716,000 729,000 742,000 1,067,000 143,000  168,000 181,000 194,000 207,000 220,000 233,000 246,000 318,000 270,000 286,000 302,000 583,000              
  preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at december 31, 2012 and 2011                                                                                     
  investment in joint venture                                                      564,000 1,421,000 1,801,000 2,709,000 3,616,000 20,000 1,183,000 5,032,000 6,435,000 7,867,000 8,901 9,713,000 1,583,000 4,699,000 6,412,000 7,684,000 9,129,000 9,901,000              
  intangible assets                                                   145,000 188,000 231,000 275,000 318,000 361,000 405,000 448,000 491,000 535,000 578,000 622,000 665,000 708,000 751,000 795,000 838,000 882,000 925,000 968,000 1,610,000 1,737,000 1,835,000 1,933,000    2,491,000    3,405,000 3,523,000 3,642,000 
  preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at september 30, 2012 and december 31, 2011                                                                                     
  accumulated other comprehensive gain                                                   108,000                        263,000 113,000         
  preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at june 30, 2012 and december 31, 2011                                                                                     
  preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at march 31, 2012 and december 31, 2011                                                                                     
  income taxes receivable                                                          10,669,000                           
  preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at december 31, 2011 and 2010                                                                                     
  collaboration receivables                                                       2,027,000 1,308,000 1,150,000 3,450,000 4,881,000 6,358,000 4,505,000 6,044,000 5,022,000 5,857,000 5,831,000 4,188,000 24,140,000 5,126,000 9,680,000 5,031,000 5,129,000 5,615,000 4,393,000 3,829,000 4,847,000 3,591,000 3,116,000 609,000       
  preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at september 30, 2011 and december 31, 2010                                                                                     
  preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at june 30, 2011 and december 31, 2010                                                                                     
  preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at march 31, 2011 and december 31, 2010                                                                                     
  deferred tax assets, net of current portion                                                           8,570,000 8,674,000 8,674,000 8,556,000                       
  income taxes payable                                                           237,000 272,000 98,000 5,644,000 1,057,000 1,829,000 1,033,000 6,111,000 3,987,000 5,216,000 3,450,000 3,497,000 3,296,000              
  preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at december 31, 2010 and 2009                                                                                     
  preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at september 30, 2010 and december 31, 2009                                                                                     
  preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at june 30, 2010 and december 31, 2009                                                                                     
  preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at march 31, 2010 and december 31, 2009                                                                                     
  restricted cash                                                                  2,999,000 3,000,000 3,000,000 6,152,000 6,152,000 5,313,000 2,313,000 2,313,000 2,313,000 2,313,000 2,313,000 2,313,000 2,313,000 2,313,000 2,313,000 2,313,000    
  restricted cash, net of current portion                                                                 3,152,000 3,152,000 3,152,000 3,152,000                 
  preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at december 31, 2009 and 2008                                                                                     
  preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at september 30, 2009 and december 31, 2008                                                                                     
  preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at june 30, 2009 and december 31, 2008                                                                                     
  preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at march 31, 2009 and december 31, 2008                                                                                     
  current portion of notes payable                                                                   3,227,000 3,968,000 3,888,000 3,795,000 3,705,000 3,617,000 3,295,000 3,217,000 3,046,000 2,721,000 2,006,000        
  notes payable, net of current portion                                                                   719,000 938,000 1,955,000 2,963,000 3,946,000 4,906,000 5,065,000 5,919,000 6,437,000 6,334,000 5,320,000        
  preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at december 31, 2008 and 2007                                                                                     
  preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at september 30, 2008 and december 31, 2007                                                                                     
  preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at june 30, 2008 and december 31, 2007                                                                                     
  preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at march 31, 2008 and december 31, 2007                                                                                     
  preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at december 31, 2007 and 2006                                                                                     
  deferred stock-based compensation                                                                                     
  preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at september 30, 2007 and december 31, 2006                                                                                     
  deferred stock compensation                                                                        -22,000 -53,000 -89,000 -135,000 -932,000 -1,611,000 -2,460,000 -2,857,000 -2,941,000 -3,125,000 -3,697,000   
  preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at june 30, 2007 and december 31, 2006                                                                                     
  preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at march 31, 2007 and december 31, 2006                                                                                     
  related party notes receivable                                                                              146,000 283,000 281,000 297,000 310,000   
  preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at december 31, 2006 and december 31, 2005                                                                                     
  property and equipment, net of accumulated depreciation of 7,732 and 5,097 at september 30, 2006 and december 31, 2005, respectively                                                                           12,856,000          
  intangible assets, net of accumulated amortization of 1,454 and 1,143 at september 30, 2006 and december 31, 2005, respectively                                                                           2,180,000          
  preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding as of september 30, 2006 and december 31, 2005                                                                                     
  property and equipment, net of accumulated depreciation of 6,764 and 5,097 at june 30, 2006 and december 31, 2005, respectively                                                                            13,044,000         
  intangible assets, net of accumulated amortization of 1,350 and 1,143 at june 30, 2006 and december 31, 2005, respectively                                                                            2,284,000         
  preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at june 30, 2006 and december 31, 2005                                                                                     
  property and equipment, net of accumulated depreciation of 5,862 and 5,097 at march 31, 2006 and december 31, 2005, respectively                                                                             11,359,000        
  intangible assets, net of accumulated amortization of 1,247 and 1,143 at march 31, 2006 and december 31, 2005, respectively                                                                             2,387,000        
  preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at march 31, 2006 and december 31, 2005                                                                                     
  current portion of note payable                                                                              1,876,000 1,765,000 1,776,000 1,288,000 790,000 379,000  
  note payable, net of current portion                                                                              5,519,000 5,782,000 6,187,000 6,478,000 6,411,000 6,591,000 5,705,000 
  preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at december 31, 2005 and december 31, 2004                                                                                     
  collaboration receivable                                                                               304,000  1,867,000 859,000 916,000 3,000,000 
  property and equipment, net of accumulated depreciation of 4,403 and 2,463 at september 30, 2005 and december 31, 2004, respectively                                                                               10,760,000      
  intangible assets, net of accumulated amortization of 1,025 and 670 at september 30, 2005 and december 31, 2004, respectively                                                                               3,050,000      
  accrued liabilities                                                                               2,986,000 4,243,000 1,678,000 3,875,000 3,740,000 5,443,000 
  preferred stock, 0.01 par value, 5,000,000 shares authorized; no shares issued or outstanding as of september 30, 2005 or december 31, 2004                                                                                     
  collaboration and license receivables                                                                                679,000     
  property and equipment, net of accumulated depreciation of 3,704 and 2,464 at june 30, 2005 and december 31, 2004, respectively                                                                                11,084,000     
  intangible assets, net of accumulated amortization of 907 and 670 at june 30, 2005 and december 31, 2004, respectively                                                                                3,168,000     
  preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at june 30, 2005 and no shares authorized, issued or outstanding at december 31, 2004                                                                                     
  property and equipment, net of accumulated depreciation of 3,063 and 2,463 at march 31, 2005 and december 31, 2004, respectively                                                                                 11,540,000    
  intangible assets, net of accumulated amortization of 788 and 670 at march 31, 2005 and december 31, 2004, respectively                                                                                 3,287,000    
  preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at march 31, 2005 and december 31, 2004                                                                                     
  liabilities, redeemable convertible preferred stock and stockholders’ equity                                                                                     
  redeemable convertible preferred stock                                                                                     
  deferred financing costs                                                                                   542,000 571,000 
  deferred compensation                                                                                   -4,359,000 -6,125,000 
  total liabilities, redeemable convertible preferred stock and stockholders’ equity                                                                                   62,545,000 68,473,000 
  current assets                                                                                     
  current liabilities                                                                                     

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