Quarterly
Annual
| Unit: USD | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2017-12-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | 2016-12-31 | 2016-09-30 | 2016-06-30 | 2016-03-31 | 2015-12-31 | 2015-09-30 | 2015-06-30 | 2015-03-31 | 2014-12-31 | 2014-09-30 | 2014-06-30 | 2014-03-31 | 2013-12-31 | 2013-09-30 | 2013-06-30 | 2013-03-31 | 2012-12-31 | 2012-09-30 | 2012-06-30 | 2012-03-31 | 2011-12-31 | 2011-09-30 | 2011-06-30 | 2011-03-31 | 2010-12-31 | 2010-09-30 | 2010-06-30 | 2010-03-31 | 2009-12-31 | 2009-09-30 | 2009-06-30 | 2009-03-31 | 2008-12-31 | 2008-09-30 | 2008-06-30 | 2008-03-31 | 2007-12-31 | 2007-09-30 | 2007-06-30 | 2007-03-31 | 2006-12-31 | 2006-09-30 | 2006-06-30 | 2006-03-31 | 2005-12-31 | 2005-09-30 | 2005-06-30 | 2005-03-31 | 2004-12-31 | 2004-09-30 | 2004-06-30 |
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assets | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current assets: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents | 1,490,249,000 | 1,113,685,000 | 1,019,654,000 | 966,428,000 | 1,099,920,000 | 968,492,000 | 681,879,000 | 812,688,000 | 1,033,024,000 | 657,800,000 | 672,245,000 | 866,394,000 | 1,073,228,000 | 575,558,000 | 534,081,000 | 819,975,000 | 1,093,991,000 | 745,767,000 | 379,543,000 | 496,580,000 | 496,704,000 | 580,829,000 | 467,779,000 | 547,178,000 | 923,304,000 | 1,136,289,000 | 724,959,000 | 420,146,000 | 316,608,000 | 361,457,000 | 396,149,000 | 645,361,000 | 202,045,000 | 408,671,000 | 171,079,000 | 193,617,000 | 168,481,000 | 271,076,000 | 231,278,000 | 180,895,000 | 149,218,000 | 151,262,000 | 306,580,000 | 75,179,000 | 82,721,000 | 80,727,000 | 350,589,000 | 53,169,000 | 11,840,000 | 24,975,000 | 97,804,000 | 51,405,000 | 75,838,000 | 48,274,000 | 61,739,000 | 70,228,000 | 74,336,000 | 67,110,000 | 90,590,000 | 74,599,000 | 46,881,000 | 66,182,000 | 114,947,000 | 137,468,000 | 98,087,000 | 147,870,000 | 227,268,000 | 191,792,000 | 196,737,000 | 247,536,000 | 196,281,000 | 105,157,000 | 200,547,000 | 84,464,000 | 66,662,000 | 127,955,000 | 35,516,000 | 35,645,000 | 56,804,000 | 15,757,000 | 7,178,000 | 9,165,000 | 12,215,000 | 20,272,000 | 14,544,000 | 31,891,000 |
marketable debt securities | 1,234,375,000 | 1,743,900,000 | 1,605,368,000 | 1,719,920,000 | 1,671,993,000 | 1,646,268,000 | 1,678,147,000 | 1,615,516,000 | 1,362,843,000 | 1,372,451,000 | 1,372,574,000 | 1,297,890,000 | 1,169,050,000 | 1,504,154,000 | 1,673,485,000 | 1,548,617,000 | 1,161,324,000 | 1,101,782,000 | 1,273,027,000 | 1,333,182,000 | 1,279,955,000 | 1,258,425,000 | 836,346,000 | 975,017,000 | 797,754,000 | 790,542,000 | 519,578,000 | 662,803,000 | 905,222,000 | 1,074,165,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
marketable equity securities | 7,200,000 | 8,156,000 | 8,322,000 | 9,889,000 | 11,256,000 | 11,178,000 | 10,411,000 | 27,256,000 | 25,856,000 | 28,122,000 | 23,051,000 | 30,901,000 | 31,997,000 | 66,972,000 | 72,550,000 | 52,533,000 | 56,967,000 | 44,633,000 | 57,217,000 | 86,310,000 | 38,078,000 | 13,967,000 | 1,206,000 | 15,004,000 | 12,044,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts receivable | 964,768,000 | 567,112,000 | 418,035,000 | 405,308,000 | 353,852,000 | 309,481,000 | 321,377,000 | 327,787,000 | 325,445,000 | 220,635,000 | 219,434,000 | 237,963,000 | 184,513,000 | 142,271,000 | 156,533,000 | 198,571,000 | 141,064,000 | 146,587,000 | 110,626,000 | 102,413,000 | 79,118,000 | 69,115,000 | 75,572,000 | 43,011,000 | 48,109,000 | 30,739,000 | 33,801,000 | 18,760,000 | 3,362,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
inventory | 75,383,000 | 71,688,000 | 65,581,000 | 78,509,000 | 75,987,000 | 83,981,000 | 93,988,000 | 89,146,000 | 95,771,000 | 100,453,000 | 131,879,000 | 128,962,000 | 115,489,000 | 88,976,000 | 78,516,000 | 86,363,000 | 97,899,000 | 84,358,000 | 73,940,000 | 75,202,000 | 66,942,000 | 77,418,000 | 68,300,000 | 56,348,000 | 54,562,000 | 40,587,000 | 32,001,000 | 24,068,000 | 11,081,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
prepaid expenses and other current assets | 188,036,000 | 147,314,000 | 152,420,000 | 116,964,000 | 145,350,000 | 154,745,000 | 201,960,000 | 126,382,000 | 157,958,000 | 145,452,000 | 119,030,000 | 132,916,000 | 125,516,000 | 129,778,000 | 115,065,000 | 88,078,000 | 108,534,000 | 94,136,000 | 75,980,000 | 62,767,000 | 74,766,000 | 88,349,000 | 98,698,000 | 80,343,000 | 73,536,000 | 65,616,000 | 81,674,000 | 73,713,000 | 90,843,000 | 51,932,000 | 66,665,000 | 40,120,000 | 30,430,000 | 22,033,000 | 18,127,000 | 21,744,000 | 19,282,000 | 22,152,000 | 27,626,000 | 16,559,000 | 17,453,000 | 15,117,000 | 13,206,000 | 9,739,000 | 10,699,000 | 10,270,000 | 8,409,000 | 3,910,000 | 4,776,000 | 4,205,000 | 3,542,000 | 2,540,000 | 5,679,000 | 6,933,000 | 7,252,000 | 4,158,000 | 4,909,000 | 5,077,000 | 4,919,000 | 6,889,000 | 6,432,000 | 6,021,000 | 5,109,000 | 4,151,000 | 5,173,000 | 5,327,000 | 5,454,000 | 4,674,000 | 4,523,000 | 4,182,000 | 1,922,000 | 2,926,000 | 4,125,000 | 1,575,000 | 1,057,000 | 1,695,000 | 1,706,000 | 2,199,000 | 1,729,000 | 1,657,000 | 1,301,000 | 1,238,000 | 988,000 | 966,000 | 1,345,000 | 1,413,000 |
total current assets | 3,952,811,000 | 3,643,699,000 | 3,268,258,000 | 3,295,285,000 | 3,355,424,000 | 3,172,856,000 | 2,988,607,000 | 2,982,697,000 | 2,985,452,000 | 2,524,047,000 | 2,541,018,000 | 2,692,247,000 | 2,690,847,000 | 2,471,638,000 | 2,589,677,000 | 2,808,576,000 | 2,675,362,000 | 2,725,163,000 | 2,470,083,000 | 2,614,777,000 | 2,554,702,000 | 2,160,446,000 | 1,584,773,000 | 1,715,864,000 | 1,897,265,000 | 2,063,773,000 | 1,392,013,000 | 1,200,696,000 | 1,342,120,000 | 1,502,559,000 | 1,685,297,000 | 1,764,740,000 | 993,368,000 | 960,709,000 | 597,188,000 | 671,877,000 | 747,564,000 | 888,068,000 | 1,050,074,000 | 1,105,388,000 | 1,041,793,000 | 1,029,150,000 | 1,090,186,000 | 746,367,000 | 643,017,000 | 665,121,000 | 674,063,000 | 254,028,000 | 199,164,000 | 214,359,000 | 240,111,000 | 125,456,000 | 235,933,000 | 240,342,000 | 208,539,000 | 152,028,000 | 179,957,000 | 224,334,000 | 250,709,000 | 254,139,000 | 244,623,000 | 273,510,000 | 273,309,000 | 293,534,000 | 228,165,000 | 278,422,000 | 419,339,000 | 442,249,000 | 451,779,000 | 550,631,000 | 455,475,000 | 463,559,000 | 477,632,000 | 201,958,000 | 209,916,000 | 222,784,000 | 126,827,000 | 129,057,000 | 137,120,000 | 82,414,000 | 26,697,000 | 33,840,000 | 41,442,000 | 47,198,000 | 50,511,000 | |
property, plant and equipment | 501,754,000 | 499,791,000 | 498,684,000 | 502,784,000 | 506,997,000 | 517,159,000 | 523,460,000 | 526,057,000 | 525,591,000 | 527,474,000 | 523,032,000 | 523,494,000 | 514,821,000 | 508,201,000 | 504,389,000 | 501,958,000 | 484,941,000 | 470,700,000 | 464,572,000 | 465,029,000 | 444,690,000 | 439,126,000 | 429,814,000 | 425,179,000 | 396,456,000 | 371,769,000 | 341,712,000 | 320,658,000 | 272,652,000 | 227,839,000 | 201,979,000 | 181,900,000 | 161,899,000 | 147,533,000 | 129,962,000 | 114,572,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||
operating lease right-of-use assets | 191,390,000 | 192,401,000 | 197,233,000 | 191,148,000 | 196,408,000 | 198,303,000 | 195,468,000 | 199,732,000 | 203,485,000 | 208,801,000 | 215,049,000 | 215,136,000 | 218,802,000 | 223,921,000 | 228,769,000 | 231,675,000 | 235,853,000 | 238,089,000 | 237,213,000 | 241,485,000 | 245,234,000 | 229,674,000 | 221,280,000 | 221,197,000 | 223,444,000 | 226,357,000 | 226,412,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred tax assets | 98,558,000 | 104,363,000 | 107,224,000 | 116,863,000 | 9,406,000 | 19,654,000 | 33,667,000 | 31,667,000 | 1,943,000 | 1,937,000 | 1,937,000 | 1,937,000 | 5,312,000 | 5,606,000 | 5,606,000 | 5,382,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
restricted investments | 51,314,000 | 68,593,000 | 68,592,000 | 68,593,000 | 68,592,000 | 49,391,000 | 49,390,000 | 49,391,000 | 49,390,000 | 49,388,000 | 49,388,000 | 49,390,000 | 49,389,000 | 49,390,000 | 40,889,000 | 40,891,000 | 40,890,000 | 40,890,000 | 40,725,000 | 40,725,000 | 24,725,000 | 24,725,000 | 24,725,000 | 14,825,000 | 14,825,000 | 44,825,000 | 44,825,000 | 44,825,000 | 44,825,000 | 44,825,000 | 30,000,000 | 30,000,000 | 150,000,000 | 150,000,000 | 150,000,000 | 150,000,000 | 150,000,000 | 150,000,000 | ||||||||||||||||||||||||||||||||||||||||||||||||
other assets | 55,835,000 | 57,172,000 | 73,820,000 | 65,310,000 | 77,618,000 | 71,925,000 | 67,461,000 | 72,003,000 | 75,155,000 | 92,686,000 | 63,453,000 | 66,092,000 | 61,396,000 | 77,267,000 | 69,821,000 | 60,204,000 | 35,267,000 | 34,587,000 | 42,676,000 | 45,045,000 | 37,932,000 | 20,396,000 | 19,032,000 | 18,069,000 | 9,632,000 | 9,687,000 | 9,037,000 | 8,623,000 | 16,057,000 | 14,166,000 | 5,215,000 | 4,171,000 | 1,471,000 | 1,471,000 | 1,471,000 | 1,562,000 | 1,561,000 | 1,471,000 | 1,471,000 | 1,471,000 | 101,000 | 89,000 | 116,000 | 145,000 | 173,000 | 201,000 | 685,000 | 749,000 | 803,000 | 351,000 | 416,000 | 508,000 | 550,000 | 428,000 | 457,000 | 485,000 | 514,000 | |||||||||||||||||||||||||||||
total assets | 4,851,662,000 | 4,566,019,000 | 4,213,811,000 | 4,239,983,000 | 4,205,039,000 | 4,009,634,000 | 3,824,386,000 | 3,829,880,000 | 3,839,073,000 | 3,402,396,000 | 3,391,940,000 | 3,546,359,000 | 3,535,255,000 | 3,330,417,000 | 3,433,545,000 | 3,643,304,000 | 3,472,313,000 | 3,509,429,000 | 3,255,269,000 | 3,407,061,000 | 3,307,283,000 | 3,374,367,000 | 2,279,624,000 | 2,395,134,000 | 2,541,622,000 | 2,716,411,000 | 2,013,999,000 | 1,574,802,000 | 1,675,654,000 | 1,789,389,000 | 1,923,139,000 | 1,994,730,000 | 1,358,281,000 | 1,434,283,000 | 1,133,926,000 | 1,262,810,000 | 1,312,910,000 | 1,382,162,000 | 1,316,949,000 | 1,386,510,000 | 1,436,144,000 | 1,530,771,000 | 1,628,790,000 | 1,079,595,000 | 986,357,000 | 1,032,659,000 | 1,080,297,000 | 420,530,000 | 447,503,000 | 462,558,000 | 471,578,000 | 287,520,000 | 322,352,000 | 318,477,000 | 340,295,000 | 281,917,000 | 310,223,000 | 340,828,000 | 369,052,000 | 393,265,000 | 412,606,000 | 440,180,000 | 463,406,000 | 481,385,000 | 495,668,000 | 518,653,000 | 554,529,000 | 554,676,000 | 580,181,000 | 580,046,000 | 486,256,000 | 493,791,000 | 505,091,000 | 219,658,000 | 227,340,000 | 240,006,000 | 144,527,000 | 147,114,000 | 153,687,000 | 98,348,000 | 43,248,000 | 50,862,000 | 59,067,000 | 62,545,000 | 68,473,000 | |
liabilities and stockholders' equity | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current liabilities: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts payable | 117,591,000 | 102,393,000 | 97,399,000 | 88,415,000 | 70,805,000 | 73,980,000 | 78,148,000 | 55,519,000 | 73,840,000 | 59,746,000 | 62,237,000 | 98,094,000 | 40,572,000 | 52,418,000 | 54,916,000 | 73,426,000 | 40,048,000 | 53,079,000 | 45,381,000 | 51,966,000 | 27,872,000 | 26,125,000 | 40,484,000 | 49,884,000 | 39,392,000 | 71,215,000 | 22,671,000 | 59,708,000 | 21,772,000 | 11,988,000 | 13,206,000 | 28,355,000 | 9,239,000 | 23,170,000 | 25,371,000 | 54,465,000 | 23,137,000 | 12,824,000 | 17,442,000 | 16,787,000 | 14,272,000 | 15,715,000 | 15,486,000 | 15,111,000 | 5,201,000 | 6,168,000 | 5,037,000 | 5,896,000 | 2,728,000 | 4,534,000 | 3,105,000 | 4,420,000 | 5,093,000 | 5,519,000 | 4,339,000 | 5,800,000 | 5,486,000 | 7,949,000 | 5,800,000 | 9,312,000 | 6,561,000 | 10,398,000 | 6,988,000 | 12,489,000 | 8,426,000 | 6,463,000 | 8,729,000 | 2,588,000 | 3,342,000 | 6,240,000 | 9,084,000 | 3,826,000 | 7,057,000 | 5,669,000 | 3,007,000 | 4,085,000 | 2,456,000 | 3,698,000 | 3,928,000 | 1,975,000 | 1,985,000 | 1,612,000 | 1,653,000 | 910,000 | 1,450,000 | 1,810,000 |
accrued expenses | 1,153,648,000 | 918,966,000 | 704,165,000 | 887,472,000 | 946,168,000 | 808,643,000 | 698,865,000 | 713,013,000 | 713,094,000 | 598,530,000 | 508,599,000 | 545,460,000 | 510,579,000 | 421,243,000 | 355,936,000 | 395,174,000 | 388,576,000 | 341,187,000 | 280,527,000 | 355,909,000 | 295,260,000 | 211,186,000 | 183,221,000 | 197,201,000 | 177,948,000 | 138,800,000 | 106,873,000 | 112,719,000 | 93,564,000 | 89,867,000 | 63,824,000 | 72,203,000 | 51,260,000 | 43,820,000 | 31,842,000 | 42,118,000 | 36,211,000 | 37,551,000 | 30,805,000 | 28,798,000 | 18,444,000 | 17,758,000 | 14,427,000 | 23,680,000 | 19,799,000 | 15,783,000 | 16,600,000 | 14,160,000 | 15,386,000 | 8,488,000 | 9,086,000 | 11,558,000 | 14,914,000 | 14,228,000 | 13,006,000 | 12,340,000 | 12,230,000 | 11,380,000 | 12,050,000 | 11,116,000 | 10,880,000 | 7,425,000 | 8,754,000 | 9,833,000 | 8,381,000 | 9,908,000 | 10,389,000 | 9,328,000 | 9,859,000 | 9,497,000 | 9,666,000 | 11,724,000 | 11,746,000 | 9,980,000 | 7,297,000 | 4,479,000 | 5,104,000 | 4,583,000 | 3,669,000 | 3,899,000 | ||||||
operating lease liabilities | 44,755,000 | 46,097,000 | 46,011,000 | 41,886,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred revenue | 2,541,000 | 15,080,000 | 28,160,000 | 55,481,000 | 71,030,000 | 69,009,000 | 76,850,000 | 102,753,000 | 77,140,000 | 54,639,000 | 35,794,000 | 42,105,000 | 144,208,000 | 114,292,000 | 131,838,000 | 149,483,000 | 115,044,000 | 98,144,000 | 116,340,000 | 127,207,000 | 114,601,000 | 107,587,000 | 86,043,000 | 77,821,000 | 107,359,000 | 89,242,000 | 2,642,000 | 3,496,000 | 3,444,000 | 9,161,000 | 35,855,000 | 41,705,000 | 38,532,000 | 39,794,000 | 36,755,000 | 33,540,000 | 21,087,000 | 18,885,000 | 16,944,000 | 15,352,000 | 13,973,000 | 12,460,000 | 14,099,000 | 23,871,000 | 30,270,000 | 27,002,000 | 29,121,000 | 32,696,000 | 33,558,000 | 33,560,000 | 33,548,000 | 31,417,000 | 31,156,000 | 35,345,000 | 48,410,000 | 62,366,000 | 75,727,000 | 80,721,000 | 81,010,000 | 81,134,000 | 81,270,000 | 83,100,000 | 81,893,000 | 81,929,000 | 82,420,000 | 82,570,000 | 82,539,000 | 79,864,000 | 80,048,000 | 80,806,000 | 58,822,000 | 59,249,000 | 61,652,000 | 7,840,000 | 9,899,000 | 11,144,000 | 10,924,000 | 9,599,000 | 10,387,000 | 10,734,000 | 1,266,000 | 1,390,000 | 1,519,000 | 1,000,000 | 1,071,000 | 1,451,000 |
liability related to the sale of future royalties | 115,691,000 | 97,523,000 | 81,793,000 | 113,018,000 | 90,516,000 | 61,963,000 | 46,174,000 | 54,991,000 | 44,195,000 | 33,650,000 | 23,706,000 | 40,289,000 | 35,851,000 | 28,496,000 | 21,983,000 | 37,079,000 | 26,376,000 | 22,876,000 | 13,660,000 | 13,316,000 | 10,316,000 | 5,957,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
development derivative liability | 121,251,000 | 120,788,000 | 118,095,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total current liabilities | 1,555,477,000 | 1,300,847,000 | 1,075,623,000 | 1,186,272,000 | 1,220,663,000 | 1,055,251,000 | 941,709,000 | 967,786,000 | 949,785,000 | 788,639,000 | 673,391,000 | 767,915,000 | 772,791,000 | 657,685,000 | 605,963,000 | 695,710,000 | 610,656,000 | 554,648,000 | 494,825,000 | 585,270,000 | 480,241,000 | 384,302,000 | 338,791,000 | 352,594,000 | 352,864,000 | 328,604,000 | 149,163,000 | 179,494,000 | 121,503,000 | 113,659,000 | 115,383,000 | 144,251,000 | 101,045,000 | 108,726,000 | 95,786,000 | 131,699,000 | 81,761,000 | 70,575,000 | 66,369,000 | 62,099,000 | 57,112,000 | 66,598,000 | 80,693,000 | 95,334,000 | 56,849,000 | 53,745,000 | 83,831,000 | 53,864,000 | 54,895,000 | 53,066,000 | 49,750,000 | 48,345,000 | 54,758,000 | 57,064,000 | 66,638,000 | 80,990,000 | 93,927,000 | 100,534,000 | 99,344,000 | 102,046,000 | 99,433,000 | 102,033,000 | 98,571,000 | 110,733,000 | 101,121,000 | 102,331,000 | 104,251,000 | 99,452,000 | 102,024,000 | 105,727,000 | 84,910,000 | 82,091,000 | 87,456,000 | 27,106,000 | 23,498,000 | 22,925,000 | 21,530,000 | 20,601,000 | 19,990,000 | 18,484,000 | 8,002,000 | 9,021,000 | 6,138,000 | 6,640,000 | 8,704,000 | |
operating lease liabilities, net of current portion | 223,421,000 | 224,445,000 | 230,061,000 | 229,541,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible debt | 1,040,276,000 | 1,026,522,000 | 1,025,566,000 | 1,024,621,000 | 1,023,654,000 | 1,022,688,000 | 1,021,732,000 | 1,020,776,000 | 1,019,809,000 | 1,018,843,000 | 1,017,887,000 | 1,016,942,000 | 1,015,975,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liability related to the sale of future royalties, net of current portion | 1,349,166,000 | 1,345,147,000 | 1,338,821,000 | 1,334,353,000 | 1,333,849,000 | 1,342,580,000 | 1,336,892,000 | 1,322,248,000 | 1,310,814,000 | 1,298,446,000 | 1,285,200,000 | 1,252,015,000 | 1,231,873,000 | 1,214,311,000 | 1,193,822,000 | 1,151,024,000 | 1,132,362,000 | 1,105,685,000 | 1,086,065,000 | 1,058,225,000 | 1,032,708,000 | 1,008,336,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
development derivative liability, net of current portion | 439,659,000 | 407,535,000 | 422,434,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other liabilities | 9,769,000 | 10,932,000 | 5,871,000 | 398,108,000 | 357,477,000 | 350,428,000 | 319,990,000 | 308,438,000 | 280,734,000 | 257,054,000 | 224,046,000 | 212,580,000 | 183,001,000 | 157,301,000 | 120,828,000 | 98,963,000 | 76,450,000 | 71,633,000 | 60,461,000 | 37,908,000 | 16,341,000 | 18,855,000 | 9,198,000 | 9,330,000 | 9,036,000 | 9,514,000 | 5,072,000 | 4,965,000 | 4,335,000 | 4,186,000 | 4,458,000 | 4,347,000 | 2,842,000 | 2,815,000 | 3,184,000 | 3,067,000 | 1,991,000 | 1,777,000 | 1,373,000 | 1,301,000 | 500,000 | 1,000,000 | 1,000,000 | |||||||||||||||||||||||||||||||||||||||||||
total liabilities | 4,617,768,000 | 4,315,428,000 | 4,098,376,000 | 4,172,895,000 | 4,172,685,000 | 4,012,701,000 | 4,043,658,000 | 4,050,524,000 | 4,004,939,000 | 3,810,527,000 | 3,651,180,000 | 3,704,582,000 | 3,602,893,000 | 3,154,377,000 | 3,032,379,000 | 3,055,101,000 | 2,716,420,000 | 2,656,067,000 | 2,329,079,000 | 2,390,814,000 | 2,092,260,000 | 1,974,641,000 | 929,895,000 | 956,442,000 | 934,535,000 | 959,216,000 | 467,013,000 | 272,837,000 | 197,535,000 | 168,587,000 | 168,334,000 | 228,299,000 | 299,446,000 | 311,317,000 | 303,025,000 | 342,589,000 | 297,942,000 | 283,680,000 | 127,898,000 | 121,796,000 | 114,540,000 | 122,167,000 | 132,280,000 | 143,328,000 | 81,879,000 | 90,390,000 | 125,324,000 | 150,183,000 | 149,921,000 | 154,383,000 | 160,022,000 | 153,467,000 | 145,192,000 | 130,190,000 | 142,917,000 | 163,920,000 | 182,350,000 | 204,277,000 | 223,485,000 | 235,032,000 | 251,963,000 | 274,702,000 | 291,576,000 | 303,420,000 | 313,647,000 | 334,171,000 | 355,785,000 | 352,551,000 | 375,624,000 | 380,877,000 | 283,444,000 | 294,623,000 | 312,156,000 | 40,388,000 | 37,313,000 | 38,832,000 | 39,750,000 | 37,037,000 | 35,771,000 | 36,569,000 | 20,177,000 | 21,474,000 | 19,238,000 | 17,564,000 | 17,798,000 | |
commitments and contingencies | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stockholders' equity: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of september 30, 2025 and december 31, 2024 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
common stock | 1,318,000 | 1,310,000 | 1,303,000 | 1,293,000 | 1,289,000 | 1,281,000 | 1,265,000 | 1,259,000 | 1,255,000 | 1,250,000 | 1,243,000 | 1,240,000 | 1,230,000 | 1,210,000 | 1,207,000 | 1,202,000 | 1,195,000 | 1,186,000 | 1,173,000 | 1,164,000 | 1,161,000 | 1,156,000 | 1,131,000 | 1,122,000 | 1,113,000 | 1,110,000 | 1,064,000 | 1,011,000 | 1,009,000 | 1,005,000 | 1,005,000 | 997,000 | 924,000 | 917,000 | 861,000 | 859,000 | 858,000 | 856,000 | 855,000 | 851,000 | 847,000 | 845,000 | 842,000 | 772,000 | 767,000 | 763,000 | 755,000 | 637,000 | 632,000 | 624,000 | 621,000 | 525,000 | 524,000 | 520,000 | 519,000 | 427,000 | 427,000 | 427,000 | 424,000 | 423,000 | 422,000 | 421,000 | 419,000 | 418,000 | 418,000 | 417,000 | 414,000 | 414,000 | 414,000 | 411,000 | 408,000 | 408,000 | 406,000 | 376,000 | 375,000 | 371,000 | 322,000 | 321,000 | 320,000 | 267,000 | 212,000 | 209,000 | 209,000 | 201,000 | 200,000 | |
additional paid-in capital | 7,414,771,000 | 7,690,737,000 | 7,496,876,000 | 7,388,061,000 | 7,259,876,000 | 7,122,704,000 | 6,881,977,000 | 6,811,063,000 | 6,736,939,000 | 6,647,173,000 | 6,522,091,000 | 6,454,540,000 | 6,336,771,000 | 6,172,990,000 | 6,116,558,000 | 6,058,453,000 | 5,968,661,000 | 5,863,476,000 | 5,747,394,000 | 5,644,074,000 | 5,592,884,000 | 5,520,320,000 | 5,289,966,000 | 5,201,176,000 | 5,091,248,000 | 5,034,284,000 | 4,601,662,000 | 4,175,139,000 | 4,140,033,000 | 4,037,853,000 | 4,009,342,000 | 3,947,552,000 | 3,097,110,000 | 3,038,529,000 | 2,627,969,000 | 2,609,614,000 | 2,585,765,000 | 2,565,728,000 | 2,546,884,000 | 2,506,197,000 | 2,483,958,000 | 2,468,187,000 | 2,450,690,000 | 1,843,362,000 | 1,823,766,000 | 1,810,775,000 | 1,776,366,000 | 846,228,000 | 833,660,000 | 813,613,000 | 806,137,000 | 624,876,000 | 621,350,000 | 613,149,000 | 609,260,000 | 518,731,000 | 514,290,000 | 509,826,000 | 504,793,000 | 500,443,000 | 495,350,000 | 490,558,000 | 482,743,000 | 476,663,000 | 471,755,000 | 465,277,000 | 457,838,000 | 452,767,000 | 448,092,000 | 440,410,000 | 428,990,000 | 424,453,000 | 420,039,000 | 353,221,000 | 351,252,000 | 340,779,000 | 236,416,000 | 235,264,000 | 234,057,000 | 170,033,000 | 117,176,000 | 112,902,000 | 112,158,000 | 112,216,000 | 106,403,000 | 107,526,000 |
accumulated other comprehensive loss | -21,775,000 | -29,952,000 | -37,517,000 | -34,518,000 | -24,826,000 | -34,637,000 | -26,988,000 | -23,375,000 | -32,339,000 | -37,080,000 | -39,124,000 | -44,654,000 | -43,783,000 | -42,224,000 | -38,065,000 | -33,259,000 | -34,230,000 | -36,081,000 | -36,717,000 | -43,622,000 | -37,193,000 | -33,212,000 | -32,059,000 | -36,518,000 | -34,371,000 | -35,831,000 | -32,853,000 | -33,213,000 | -33,392,000 | -33,807,000 | -34,853,000 | -34,433,000 | -33,741,000 | -33,959,000 | -33,828,000 | -62,000 | -37,000 | -71,000 | ||||||||||||||||||||||||||||||||||||||||||||||||
accumulated deficit | -7,160,420,000 | -7,411,504,000 | -7,345,227,000 | -7,287,748,000 | -7,203,985,000 | -7,092,415,000 | -7,075,526,000 | -7,009,591,000 | -6,871,721,000 | -7,019,474,000 | -6,743,450,000 | -6,569,349,000 | -6,361,856,000 | -5,955,936,000 | -5,678,534,000 | -5,438,193,000 | -5,179,733,000 | -4,975,219,000 | -4,785,660,000 | -4,585,369,000 | -4,341,829,000 | -4,088,538,000 | -3,909,309,000 | -3,727,088,000 | -3,450,903,000 | -3,242,368,000 | -3,022,887,000 | -2,840,972,000 | -2,629,531,000 | -2,384,249,000 | -2,220,689,000 | -2,147,685,000 | -2,005,458,000 | -1,882,521,000 | -1,764,101,000 | -1,656,811,000 | -1,543,877,000 | -1,439,806,000 | -1,349,677,000 | -1,246,703,000 | -1,155,982,000 | -1,079,190,000 | -1,007,407,000 | -956,630,000 | -935,241,000 | -891,252,000 | -847,178,000 | -596,235,000 | -563,878,000 | -534,192,000 | -516,023,000 | -507,010,000 | -444,822,000 | -425,320,000 | -412,364,000 | -400,996,000 | -386,693,000 | -373,456,000 | -359,632,000 | -343,347,000 | -336,417,000 | -326,787,000 | -312,155,000 | -299,832,000 | -292,041,000 | -282,833,000 | -260,131,000 | -252,242,000 | -242,850,000 | -239,992,000 | -227,232,000 | -225,993,000 | -227,655,000 | -174,863,000 | -162,171,000 | -140,527,000 | -132,089,000 | -124,689,000 | -114,779,000 | -105,919,000 | -91,428,000 | -80,750,000 | -69,604,000 | -63,005,000 | -57,305,000 | -50,889,000 |
total stockholders' equity | 233,894,000 | 250,591,000 | 115,435,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total liabilities and stockholders' equity | 4,851,662,000 | 4,566,019,000 | 4,213,811,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of june 30, 2025 and december 31, 2024 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of march 31, 2025 and december 31, 2024 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liabilities and stockholders’ equity | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred revenue, net of current portion | 1,012,000 | 2,402,000 | 185,506,000 | 188,175,000 | 196,086,000 | 194,129,000 | 191,257,000 | 193,791,000 | 132,930,000 | 175,341,000 | 157,668,000 | 152,360,000 | 177,123,000 | 202,391,000 | 208,123,000 | 225,094,000 | 265,708,000 | 281,530,000 | 306,124,000 | 318,383,000 | 296,179,000 | 313,887,000 | 478,000 | 458,000 | 1,623,000 | 4,522,000 | 7,676,000 | 43,075,000 | 38,356,000 | 42,079,000 | 46,049,000 | 49,392,000 | 55,894,000 | 54,810,000 | 53,952,000 | 52,965,000 | 52,117,000 | 50,256,000 | 46,566,000 | 42,983,000 | 20,028,000 | 32,548,000 | 37,674,000 | 93,394,000 | 91,779,000 | 97,636,000 | 105,980,000 | 100,874,000 | 85,029,000 | 68,108,000 | 72,374,000 | 78,487,000 | 84,810,000 | 100,122,000 | 120,200,000 | 129,974,000 | 149,666,000 | 169,958,000 | 190,248,000 | 189,884,000 | 209,677,000 | 229,669,000 | 248,959,000 | 250,121,000 | 269,441,000 | 268,868,000 | 191,440,000 | 204,067,000 | 217,051,000 | 5,105,000 | 5,655,000 | 6,786,000 | 8,473,000 | 6,685,000 | 8,070,000 | 10,099,000 | ||||||||||
stockholders’ equity | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of december 31, 2024 and december 31, 2023 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total stockholders’ equity | 67,088,000 | 32,354,000 | 176,040,000 | 401,166,000 | 588,203,000 | 755,893,000 | 853,362,000 | 926,190,000 | 1,016,247,000 | 1,215,023,000 | 1,399,726,000 | 1,349,729,000 | 1,438,692,000 | 1,607,087,000 | 1,757,195,000 | 1,546,986,000 | 1,301,965,000 | 1,478,119,000 | 1,620,802,000 | 1,754,805,000 | 1,766,431,000 | 1,058,835,000 | 1,122,966,000 | 830,901,000 | 920,221,000 | 1,014,968,000 | 1,098,482,000 | 1,189,051,000 | 1,264,714,000 | 1,321,604,000 | 1,408,604,000 | 1,496,510,000 | 936,267,000 | 904,478,000 | 942,269,000 | 954,973,000 | 270,347,000 | 297,582,000 | 308,175,000 | 311,556,000 | 134,053,000 | 177,160,000 | 188,287,000 | 197,378,000 | 117,997,000 | 127,873,000 | 136,551,000 | 145,567,000 | 158,233,000 | 160,643,000 | 165,478,000 | 171,830,000 | 177,965,000 | 182,021,000 | 184,482,000 | 198,744,000 | 202,125,000 | 204,557,000 | 199,169,000 | 202,812,000 | 199,168,000 | 192,935,000 | 179,270,000 | 190,027,000 | 201,174,000 | 104,777,000 | 110,077,000 | 117,916,000 | 61,779,000 | 23,071,000 | 29,388,000 | 39,829,000 | 44,981,000 | 50,675,000 | ||||||||||||
total liabilities and stockholders’ equity | 4,239,983,000 | 4,205,039,000 | 3,330,417,000 | 3,433,545,000 | 3,643,304,000 | 3,472,313,000 | 3,509,429,000 | 3,255,269,000 | 3,407,061,000 | 3,307,283,000 | 3,374,367,000 | 2,279,624,000 | 2,395,134,000 | 2,541,622,000 | 2,716,411,000 | 2,013,999,000 | 1,574,802,000 | 1,675,654,000 | 1,789,389,000 | 1,923,139,000 | 1,994,730,000 | 1,358,281,000 | 1,434,283,000 | 1,133,926,000 | 1,262,810,000 | 1,312,910,000 | 1,382,162,000 | 1,316,949,000 | 1,386,510,000 | 1,436,144,000 | 1,530,771,000 | 1,628,790,000 | 1,079,595,000 | 986,357,000 | 1,032,659,000 | 1,080,297,000 | 420,530,000 | 447,503,000 | 462,558,000 | 471,578,000 | 287,520,000 | 322,352,000 | 318,477,000 | 340,295,000 | 281,917,000 | 310,223,000 | 340,828,000 | 369,052,000 | 393,265,000 | 412,606,000 | 440,180,000 | 463,406,000 | 481,385,000 | 495,668,000 | 518,653,000 | 554,529,000 | 554,676,000 | 580,181,000 | 580,046,000 | 486,256,000 | 493,791,000 | 505,091,000 | 219,658,000 | 227,340,000 | 240,006,000 | 144,527,000 | 147,114,000 | 153,687,000 | 98,348,000 | 43,248,000 | 50,862,000 | 59,067,000 | ||||||||||||||
operating lease liability | 42,144,000 | 41,656,000 | 41,672,000 | 41,510,000 | 41,516,000 | 42,074,000 | 43,055,000 | 41,967,000 | 41,581,000 | 41,236,000 | 41,290,000 | 40,548,000 | 40,612,000 | 39,362,000 | 38,917,000 | 36,872,000 | 32,192,000 | 33,447,000 | 29,043,000 | 27,688,000 | 28,165,000 | 29,347,000 | 16,977,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
operating lease liability, net of current portion | 236,030,000 | 239,352,000 | 237,829,000 | 243,101,000 | 247,711,000 | 253,416,000 | 259,399,000 | 261,339,000 | 266,323,000 | 272,016,000 | 277,388,000 | 281,347,000 | 286,030,000 | 288,559,000 | 288,015,000 | 293,039,000 | 297,262,000 | 281,618,000 | 275,782,000 | 276,135,000 | 276,456,000 | 277,211,000 | 282,300,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of september 30, 2024 and december 31, 2023 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liabilities and stockholders’ deficit | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stockholders’ deficit: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of june 30, 2024 and december 31, 2023 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total stockholders’ deficit | -3,067,000 | -219,272,000 | -220,644,000 | -165,866,000 | -408,131,000 | -259,240,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total liabilities and stockholders’ deficit | 4,009,634,000 | 3,824,386,000 | 3,829,880,000 | 3,839,073,000 | 3,402,396,000 | 3,391,940,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of march 31, 2024 and december 31, 2023 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of december 31, 2023 and december 31, 2022 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of september 30, 2023 and december 31, 2022 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of june 30, 2023 and december 31, 2022 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of march 31, 2023 and december 31, 2022 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liabilities and stockholders’ (deficit) equity | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term debt | 677,723,000 | 676,710,000 | 675,697,000 | 433,799,000 | 433,151,000 | 191,590,000 | 191,278,000 | 30,000,000 | 30,000,000 | 30,000,000 | 30,000,000 | 30,000,000 | 30,000,000 | 30,000,000 | 150,000,000 | 150,000,000 | 150,000,000 | 150,000,000 | 150,000,000 | 150,000,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stockholders’ (deficit) equity: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of december 31, 2022 and december 31, 2021 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total stockholders’ (deficit) equity | -158,223,000 | -67,638,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total liabilities and stockholders’ (deficit) equity | 3,546,359,000 | 3,535,255,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of september 30, 2022 and december 31, 2021 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stockholders’ equity: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of june 30, 2022 and december 31, 2021 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of march 31, 2022 and december 31, 2021 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
receivable related to the sale of future royalties | 500,000,000 | 500,000,000 | 500,000,000 | 500,000,000 | 500,000,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of december 31, 2021 and december 31, 2020 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of september 30, 2021 and december 31, 2020 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of june 30, 2021 and december 31, 2020 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of march 31, 2021 and december 31, 2020 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of december 31, 2020 and december 31, 2019 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of september 30, 2020 and december 31, 2019 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of june 30, 2020 and december 31, 2019 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of march 31, 2020 and december 31, 2019 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred rent | 3,571,000 | 2,723,000 | 2,643,000 | 2,498,000 | 1,988,000 | 2,014,000 | 1,942,000 | 1,818,000 | 1,576,000 | 1,326,000 | 1,315,000 | 1,178,000 | 1,162,000 | 1,017,000 | 1,011,000 | 1,010,000 | 1,005,000 | 723,000 | 711,000 | 869,000 | 1,112,000 | 1,200,000 | 1,252,000 | 988,000 | 950,000 | 840,000 | 608,000 | 608,000 | 484,000 | 484,000 | 484,000 | 484,000 | 484,000 | 485,000 | 838,000 | 838,000 | 838,000 | 837,000 | 1,561,000 | 1,561,000 | 1,561,000 | 1,561,000 | 5,074,000 | 4,853,000 | 5,200,000 | 3,120,000 | 3,271,000 | 3,095,000 | 3,202,000 | 3,310,000 | 3,417,000 | 2,391,000 | 2,467,000 | 2,574,000 | 2,682,000 | 2,789,000 | 2,896,000 | |||||||||||||||||||||||||||||
deferred rent, net of current portion | 57,920,000 | 40,074,000 | 16,220,000 | 10,817,000 | 6,626,000 | 7,203,000 | 7,697,000 | 8,006,000 | 8,431,000 | 8,296,000 | 6,518,000 | 6,204,000 | 5,431,000 | 5,311,000 | 5,313,000 | 5,021,000 | 5,011,000 | 4,502,000 | 3,097,000 | 2,819,000 | 2,925,000 | 3,247,000 | 3,681,000 | 4,292,000 | 4,248,000 | 4,884,000 | 4,328,000 | 3,202,000 | 3,727,000 | 2,884,000 | 2,879,000 | 2,874,000 | 2,869,000 | 2,864,000 | 2,543,000 | 2,576,000 | 2,609,000 | 2,642,000 | 1,951,000 | 2,342,000 | 2,732,000 | 3,122,000 | ||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of december 31, 2019 and december 31, 2018 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of september 30, 2019 and december 31, 2018 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding at june 30, 2019 and december 31, 2018 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding at march 31, 2019 and december 31, 2018 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at december 31, 2018 and 2017 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at september 30, 2018 and december 31, 2017 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
billed and unbilled collaboration receivables | 2,961,000 | 50,768,000 | 34,002,000 | 14,644,000 | 15,405,000 | 19,457,000 | 23,334,000 | 15,146,000 | 9,514,000 | 8,814,000 | 8,298,000 | 8,130,000 | 9,403,000 | 10,107,000 | 39,937,000 | 384,000 | 89,000 | 164,000 | 4,248,000 | 609,000 | 460,000 | 558,000 | 104,000 | 1,918,000 | 4,385,000 | 2,192,000 | 1,468,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at june 30, 2018 and december 31, 2017 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
marketable securities | 1,171,715,000 | 1,045,257,000 | 746,249,000 | 514,600,000 | 385,843,000 | 424,185,000 | 531,041,000 | 571,994,000 | 748,422,000 | 848,217,000 | 828,427,000 | 788,740,000 | 660,403,000 | 526,929,000 | 507,927,000 | 524,585,000 | 314,901,000 | 192,701,000 | 181,939,000 | 184,719,000 | 138,207,000 | 71,407,000 | 152,498,000 | 180,750,000 | 137,356,000 | 76,174,000 | 98,685,000 | 150,839,000 | 154,050,000 | 158,532,000 | 184,486,000 | 193,012,000 | 146,811,000 | 143,934,000 | 119,883,000 | 119,368,000 | 180,786,000 | 238,596,000 | 223,379,000 | 290,787,000 | 247,592,000 | 350,445,000 | 267,831,000 | 110,304,000 | 137,804,000 | 89,305,000 | 84,758,000 | 87,622,000 | 75,471,000 | 64,245,000 | 17,631,000 | 22,477,000 | 26,075,000 | 30,393,000 | 14,207,000 | |||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at march 31, 2018 and december 31, 2017 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
investment in equity securities of regulus therapeutics inc. | 2,682,000 | 8,997,000 | 13,614,000 | 13,332,000 | 33,934,000 | 51,419,000 | 38,565,000 | 64,628,000 | 99,890,000 | 41,286,000 | 49,450,000 | 55,478,000 | 45,452,000 | 57,999,000 | 60,336,000 | 47,666,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at december 31, 2017 and 2016 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at september 30, 2017 and december 31, 2016 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at june 30, 2017 and december 31, 2016 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at march 31, 2017 and december 31, 2016 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at december 31, 2016 and 2015 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accumulated other comprehensive income | -33,441,000 | -27,778,000 | -28,296,000 | -9,011,000 | 4,369,000 | -7,219,000 | 18,762,000 | 52,385,000 | 48,763,000 | 15,186,000 | 21,983,000 | 25,030,000 | 19,717,000 | 27,168,000 | 28,130,000 | 20,821,000 | 15,662,000 | -165,000 | -151,000 | -246,000 | -18,000 | 714,000 | 1,288,000 | 1,286,000 | 823,000 | 716,000 | 1,889,000 | 1,621,000 | 623,000 | 1,186,000 | -1,099,000 | -1,660,000 | 646,000 | 300,000 | 145,000 | 558,000 | 624,000 | 640,000 | -142,000 | -32,000 | -32,000 | 191,000 | 420,000 | 41,000 | -37,000 | |||||||||||||||||||||||||||||||||||||||||
property and equipment | 74,219,000 | 55,394,000 | 36,814,000 | 27,812,000 | 26,316,000 | 25,169,000 | 21,166,000 | 21,740,000 | 18,806,000 | 16,953,000 | 15,731,000 | 16,448,000 | 16,974,000 | 18,045,000 | 18,983,000 | 19,799,000 | 18,792,000 | 14,206,000 | 13,703,000 | 14,643,000 | 15,309,000 | 16,252,000 | 17,021,000 | 18,289,000 | 18,399,000 | 18,554,000 | 18,304,000 | 18,324,000 | 18,152,000 | 18,483,000 | 19,321,000 | 19,194,000 | 19,577,000 | 18,853,000 | 15,875,000 | 13,810,000 | 10,434,000 | 12,965,000 | 12,527,000 | 12,173,000 | 12,856,000 | 13,044,000 | 11,359,000 | 10,580,000 | 10,760,000 | 11,084,000 | 11,540,000 | 11,694,000 | 8,969,000 | 11,436,000 | ||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at september 30, 2016 and december 31, 2015 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at june 30, 2016 and december 31, 2015 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at march 31, 2016 and december 31, 2015 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred tax liabilities | 9,406,000 | 19,654,000 | 33,667,000 | 31,667,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at december 31, 2015 and 2014 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at september 30, 2015 and december 31, 2014 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at june 30, 2015 and december 31, 2014 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accrued intraperiod tax allocation | 2,004,000 | 856,000 | 4,081,000 | 6,825,000 | 2,023,000 | 5,232,000 | 3,023,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at march 31, 2015 and december 31, 2014 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
investment in equity securities of regulus therapeutics inc | 94,583,000 | 38,748,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at december 31, 2014 and 2013 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at september 30, 2014 and december 31, 2013 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at june 30, 2014 and december 31, 2013 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liability for stock issuance | 25,379,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at march 31, 2014 and december 31, 2013 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at december 31, 2013 and 2012 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at september 30, 2013 and december 31, 2012 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at june 30, 2013 and december 31, 2012 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at march 31, 2013 and december 31, 2012 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other long-term liabilities | 521,000 | 690,000 | 703,000 | 716,000 | 729,000 | 742,000 | 1,067,000 | 143,000 | 168,000 | 181,000 | 194,000 | 207,000 | 220,000 | 233,000 | 246,000 | 318,000 | 270,000 | 286,000 | 302,000 | 583,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at december 31, 2012 and 2011 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
investment in joint venture | 564,000 | 1,421,000 | 1,801,000 | 2,709,000 | 3,616,000 | 20,000 | 1,183,000 | 5,032,000 | 6,435,000 | 7,867,000 | 8,901 | 9,713,000 | 1,583,000 | 4,699,000 | 6,412,000 | 7,684,000 | 9,129,000 | 9,901,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
intangible assets | 145,000 | 188,000 | 231,000 | 275,000 | 318,000 | 361,000 | 405,000 | 448,000 | 491,000 | 535,000 | 578,000 | 622,000 | 665,000 | 708,000 | 751,000 | 795,000 | 838,000 | 882,000 | 925,000 | 968,000 | 1,610,000 | 1,737,000 | 1,835,000 | 1,933,000 | 2,491,000 | 3,405,000 | 3,523,000 | 3,642,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at september 30, 2012 and december 31, 2011 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accumulated other comprehensive gain | 108,000 | 263,000 | 113,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at june 30, 2012 and december 31, 2011 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at march 31, 2012 and december 31, 2011 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
income taxes receivable | 10,669,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at december 31, 2011 and 2010 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
collaboration receivables | 2,027,000 | 1,308,000 | 1,150,000 | 3,450,000 | 4,881,000 | 6,358,000 | 4,505,000 | 6,044,000 | 5,022,000 | 5,857,000 | 5,831,000 | 4,188,000 | 24,140,000 | 5,126,000 | 9,680,000 | 5,031,000 | 5,129,000 | 5,615,000 | 4,393,000 | 3,829,000 | 4,847,000 | 3,591,000 | 3,116,000 | 609,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at september 30, 2011 and december 31, 2010 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at june 30, 2011 and december 31, 2010 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at march 31, 2011 and december 31, 2010 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred tax assets, net of current portion | 8,570,000 | 8,674,000 | 8,674,000 | 8,556,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
income taxes payable | 237,000 | 272,000 | 98,000 | 5,644,000 | 1,057,000 | 1,829,000 | 1,033,000 | 6,111,000 | 3,987,000 | 5,216,000 | 3,450,000 | 3,497,000 | 3,296,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value per share, 5,000,000 shares authorized and no shares issued and outstanding at december 31, 2010 and 2009 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at september 30, 2010 and december 31, 2009 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at june 30, 2010 and december 31, 2009 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at march 31, 2010 and december 31, 2009 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
restricted cash | 2,999,000 | 3,000,000 | 3,000,000 | 6,152,000 | 6,152,000 | 5,313,000 | 2,313,000 | 2,313,000 | 2,313,000 | 2,313,000 | 2,313,000 | 2,313,000 | 2,313,000 | 2,313,000 | 2,313,000 | 2,313,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
restricted cash, net of current portion | 3,152,000 | 3,152,000 | 3,152,000 | 3,152,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at december 31, 2009 and 2008 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at september 30, 2009 and december 31, 2008 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at june 30, 2009 and december 31, 2008 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at march 31, 2009 and december 31, 2008 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of notes payable | 3,227,000 | 3,968,000 | 3,888,000 | 3,795,000 | 3,705,000 | 3,617,000 | 3,295,000 | 3,217,000 | 3,046,000 | 2,721,000 | 2,006,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
notes payable, net of current portion | 719,000 | 938,000 | 1,955,000 | 2,963,000 | 3,946,000 | 4,906,000 | 5,065,000 | 5,919,000 | 6,437,000 | 6,334,000 | 5,320,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at december 31, 2008 and 2007 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at september 30, 2008 and december 31, 2007 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at june 30, 2008 and december 31, 2007 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at march 31, 2008 and december 31, 2007 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at december 31, 2007 and 2006 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred stock-based compensation | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at september 30, 2007 and december 31, 2006 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred stock compensation | -22,000 | -53,000 | -89,000 | -135,000 | -932,000 | -1,611,000 | -2,460,000 | -2,857,000 | -2,941,000 | -3,125,000 | -3,697,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at june 30, 2007 and december 31, 2006 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at march 31, 2007 and december 31, 2006 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
related party notes receivable | 146,000 | 283,000 | 281,000 | 297,000 | 310,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at december 31, 2006 and december 31, 2005 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
intangible assets, net of accumulated amortization of 1,454 and 1,143 at september 30, 2006 and december 31, 2005, respectively | 2,180,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding as of september 30, 2006 and december 31, 2005 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
intangible assets, net of accumulated amortization of 1,350 and 1,143 at june 30, 2006 and december 31, 2005, respectively | 2,284,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at june 30, 2006 and december 31, 2005 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
intangible assets, net of accumulated amortization of 1,247 and 1,143 at march 31, 2006 and december 31, 2005, respectively | 2,387,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at march 31, 2006 and december 31, 2005 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of note payable | 1,876,000 | 1,765,000 | 1,776,000 | 1,288,000 | 790,000 | 379,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
note payable, net of current portion | 5,519,000 | 5,782,000 | 6,187,000 | 6,478,000 | 6,411,000 | 6,591,000 | 5,705,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at december 31, 2005 and december 31, 2004 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
collaboration receivable | 304,000 | 1,867,000 | 859,000 | 916,000 | 3,000,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
intangible assets, net of accumulated amortization of 1,025 and 670 at september 30, 2005 and december 31, 2004, respectively | 3,050,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accrued liabilities | 2,986,000 | 4,243,000 | 1,678,000 | 3,875,000 | 3,740,000 | 5,443,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value, 5,000,000 shares authorized; no shares issued or outstanding as of september 30, 2005 or december 31, 2004 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
collaboration and license receivables | 679,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
intangible assets, net of accumulated amortization of 907 and 670 at june 30, 2005 and december 31, 2004, respectively | 3,168,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at june 30, 2005 and no shares authorized, issued or outstanding at december 31, 2004 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
intangible assets, net of accumulated amortization of 788 and 670 at march 31, 2005 and december 31, 2004, respectively | 3,287,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value, 5,000,000 shares authorized and no shares issued and outstanding at march 31, 2005 and december 31, 2004 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liabilities, redeemable convertible preferred stock and stockholders’ equity | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
redeemable convertible preferred stock | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred financing costs | 542,000 | 571,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred compensation | -4,359,000 | -6,125,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total liabilities, redeemable convertible preferred stock and stockholders’ equity | 62,545,000 | 68,473,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current assets | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current liabilities |
The information provided in this report is taken from www.sec.gov and many other data providers. While we have conducted our best efforts to ensure that the parsed data is accurate, we cannot guarantee its accuracy. Please use caution and understand that any consequences of its use are your own responsibility.