7Baggers

Allogene Therapeutics, Inc
(NASDAQ:ALLO) 

ALLO stock logo

Allogene Therapeutics, Inc., a clinical stage immuno-oncology company, develops and commercializes genetically engineered allogeneic T cell therapies for the treatment of cancer. It develops, manufactures, and commercializes UCART19, an allogeneic chimeric antigen receptor (CAR) T cell product candi...

Founded: 2017
Full Time Employees: 264
Sector: Healthcare
Industry: Biotechnology
Pharmaceuticals
Share this website to your friends
• Market Cap:
• Exchange:
• Shs Outstanding:
• Employees:
• Beta:
• Return on Equity (ROE) ttm:
• Return on Assets (ROA) ttm:
• EPS ttm:
• Book value per Share:
• Cash per Share:
• Current ast per Share:
• P/E ttm:
• P/E forward:
• P/E ttm high:
• P/E ttm low:
• P/S ttm:
• P/B ttm:
• P/FCF ttm:
• PEG ratio:
• Cash Ratio ttm:
• Quick Ratio ttm:
• Current Ratio ttm:
• Gross Mgn ttm:
• EBITDA Mgn ttm:
• Operating Mgn ttm:
• Net Income Mgn ttm:
• Trailing Div yield:
• Forward Div yield:
• Payout Ratio ttm:
• Ex-Dividend date:
• Target Price High:
• Target Price Low:
• Target Price Mean:
• Number of Analysts:
• Debt Ratio ttm:
• Debt to Equity ttm:
• Total Net Debt:
At a glance:
Bull Thesis:
Bear Thesis:
Main Competitors:
Moat:
Income Statements:
Quarterly
Annual
    Unit: USD2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 
                                  
      collaboration revenue - related party
    		       22,000 -44,000 43,000 44,000 52,000 47,000 49,000 86,000 61,000 51,000 49,000 44,000 38,345,000           
      operating expenses:
    		                              
      research and development
    		28,632,000 31,164,000 40,156,000 50,200,000 44,972,000 44,713,000 50,355,000 52,259,000 54,661,000 45,977,000 62,038,000 80,238,000 75,419,000 63,641,000 57,171,000 60,156,000 53,983,000 58,720,000 52,290,000 55,183,000 52,228,000 51,421,000 47,296,000 42,042,000 49,363,000 39,995,000 31,774,000 23,403,000 18,504,000 10,870,000 
      general and administrative
    		13,772,000 13,737,000 14,281,000 14,991,000 15,518,000 16,333,000 16,087,000 17,267,000 17,224,000 17,041,000 18,524,000 18,884,000 21,002,000 18,897,000 19,509,000 19,897,000 19,961,000 18,999,000 18,783,000 16,363,000 17,134,000 16,619,000 15,862,000 15,641,000 15,212,000 15,016,000 14,187,000 13,058,000 14,542,000 11,317,000 
      impairment of long-lived assets
    		595,500  2,382,000  3,929,250 10,728,000 4,989,000                        
      total operating expenses
    		42,404,000 44,901,000 56,819,000 65,191,000 60,490,000 71,774,000 71,431,000 69,526,000 85,130,000 63,018,000 80,562,000 99,122,000 96,421,000 82,538,000 76,680,000 80,053,000 73,944,000 77,719,000 71,073,000 71,546,000 69,362,000 68,040,000 63,158,000 57,683,000 64,575,000 55,011,000 45,961,000 36,461,000 33,046,000 22,187,000 
      income from operations
    		-42,404,000 -44,901,000 -56,819,000 -65,191,000 -60,490,000 -71,774,000 -71,431,000 -69,504,000 -85,174,000 -62,975,000 -80,518,000 -99,070,000 -96,374,000 -82,489,000 -76,594,000 -79,992,000 -73,893,000 -77,670,000 -71,029,000 -33,201,000 -69,362,000 -68,040,000 -63,158,000 -57,683,000 -64,575,000 -55,011,000 -45,961,000 -36,461,000 -33,046,000 -22,187,000 
      yoy
    		-29.90% -37.44% -20.46% -6.21% -28.98% 13.97% -11.29% -29.84% -11.62% -23.66% 5.12% 23.85% 30.42% 6.20% 7.83% 140.93% 6.53% 14.15% 12.46% -42.44% 7.41% 23.68% 37.42% 58.20% 95.41% 147.94%     
      qoq
    		-5.56% -20.98% -12.84% 7.77% -15.72% 0.48% 2.77% -18.40% 35.25% -21.79% -18.73% 2.80% 16.83% 7.70% -4.25% 8.25% -4.86% 9.35% 113.94% -52.13% 1.94% 7.73% 9.49% -10.67% 17.39% 19.69% 26.06% 10.33% 48.94%  
      other income, net:
    		                              
      interest and other income
    		3,660,000 3,926,000 6,187,000 5,516,000 3,027,000 6,705,000 4,988,000 5,433,000 6,265,000 6,205,000 3,778,000 2,059,000 2,757,000 1,002,000 315,000 492,000 186,000 393,000 624,000 511,000 1,558,000 2,005,000 2,340,000 3,261,000 3,658,000 4,309,000 4,559,000 4,825,000 4,216,000 1,463,000 
      interest expense
    		-313,000 -344,000 -268,000 -150,000 -81,000 -100,000                        -3,358,000 
      other income (expenses)
    		-8,000 -81,000 -43,000 92,000                           
      total other income
    		3,594,000 3,501,000 5,876,000 5,458,000 994,000 5,481,000 5,073,000 4,504,000 -4,083,000 1,660,000 2,529,000 366,000 1,527,000 -659,000 1,807,000 142,000 -975,000 -516,000 93,000 186,000 792,000 1,843,000 2,184,000 3,203,000     2,420,000 -21,310,000 
      net income
    		-38,810,000 -41,400,000 -50,943,000 -59,733,000 -59,939,000 -66,293,000 -66,358,000 -65,000,000 -89,257,000 -61,315,000 -77,989,000 -98,704,000 -94,847,000 -83,148,000 -74,787,000 -79,850,000 -74,868,000 -78,186,000 -70,936,000 -33,015,000 -68,570,000 -66,197,000 -60,974,000 -54,480,000 -61,030,000 -50,735,000 -41,243,000 -31,586,000 -30,509,000 -43,497,000 
      yoy
    		-35.25% -37.55% -23.23% -8.10% -32.85% 8.12% -14.91% -34.15% -5.89% -26.26% 4.28% 23.61% 26.69% 6.35% 5.43% 141.86% 9.18% 18.11% 16.34% -39.40% 12.35% 30.48% 47.84% 72.48% 100.04% 16.64%     
      qoq
    		-6.26% -18.73% -14.72% -0.34% -9.58% -0.10% 2.09% -27.18% 45.57% -21.38% -20.99% 4.07% 14.07% 11.18% -6.34% 6.65% -4.24% 10.22% 114.86% -51.85% 3.58% 8.57% 11.92% -10.73% 20.29% 23.01% 30.57% 3.53% -29.86%  
      other comprehensive loss:
    		                              
      net unrealized gain on available-for-sale investments
    		34,000 280,000 -88,000 132,000 -246,000 937,000 147,000 28,000 1,456,000 1,440,000 2,083,000 3,992,000       -233,000 -369,000 -48,000 -877,000 220,000 465,000       
      net comprehensive loss
    		-38,776,000 -41,120,000 -51,031,000 -59,601,000 -60,185,000 -65,356,000 -66,211,000 -64,972,000 -87,801,000 -59,875,000 -75,906,000 -94,712,000 -91,815,000 -84,634,000 -77,010,000 -86,532,000 -77,037,000 -78,250,000 -71,169,000 -33,384,000 -69,255,000 -67,074,000 -60,754,000 -54,015,000 -61,751,000 -51,030,000 -40,487,000 -30,487,000 -30,055,000 -43,645,000 
      net income per share
    		-0.17 -0.19 -0.23 -0.28 -0.28 -0.32 -0.35 -0.38 -0.54 -0.37 -0.53 -0.68 -0.65 -0.58 -0.52 -0.56 -0.54 -0.57 -0.53 -0.25 -0.53 -0.52 -0.53 -0.5 -0.59 -0.5 -0.41 -0.32 9.07 -10.71 
      weighted-average number of shares used in computing net loss per share, basic and diluted
    		220,622,669 222,038,680 218,929,548 215,358,619 194,811,756 209,188,551 190,026,638 169,128,362 156,931,778 167,649,010 146,795,826 144,563,829 143,147,165 143,661,721 143,385,045 141,356,306 135,820,386 137,025,698 134,826,805 132,165,014 120,370,177 127,140,755 115,377,210 108,963,522 101,061,149 102,186,644 99,846,946 97,315,890 28,948,386 4,060,419 
      other income and (expense)
    		    -492,000 -1,124,000                         
      other income and expense
    		      85,000                        
      other expenses
    		       -929,000 -10,348,000 -4,545,000  -1,693,000 -1,230,000 -1,661,000  -350,000 -1,161,000 -909,000 -531,000 -325,000 -766,000 -162,000 -156,000 -58,000       
      other (expenses) income
    		          -1,249,000                    
      net unrealized loss on available-for-sale investments
    		            3,032,000 -1,486,000 -2,223,000 -6,682,000 -166,500 -64,000             
      other income
    		              1,492,000                
      other comprehensive income:
    		                              
      income before income taxes
    		                    -68,570,000 -66,197,000 -60,974,000 -54,480,000 -61,185,000 -50,702,000 -41,402,000 -31,636,000   
      benefit from income taxes
    		                        155,000 -33,000 159,000 50,000   
      change in fair value of convertible note payable
    		                            -1,796,000 -19,415,000 
      net unrealized gain on available-for-sale investments, net of tax
    		                        -721,000 -295,000 756,000 1,099,000   
      net change in available-for-sale investments
    		                            -37,000 -148,000 
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 
                                    
        assets
      		                              
        current assets:
      		                              
        cash and cash equivalents
      		51,688,000 37,815,000 52,332,000 42,455,000 75,218,000 51,239,000 170,667,000 51,039,000 83,155,000 69,246,000 154,758,000 109,931,000 61,904,000 74,357,000 96,041,000 84,514,000 173,314,000 190,021,000 223,503,000 236,865,000 183,351,000 158,136,000 280,379,000 135,897,000 175,126,000 160,990,000 112,584,000 92,748,000 92,432,000 83,141,000 
        short-term investments
      		198,522,000 214,379,000 220,788,000 237,588,000 217,258,000 240,325,000 273,961,000 333,821,000 365,542,000 396,259,000 337,204,000 361,293,000 455,416,000 477,872,000 394,451,000 364,536,000 283,988,000 293,464,000 364,204,000 462,716,000 644,559,000 682,886,000 619,271,000 357,026,000 355,407,000 340,254,000 389,840,000 373,392,000 366,952,000 161,080,000 
        prepaid expenses and other current assets
      		7,539,000 8,525,000 9,535,000 11,533,000 10,910,000 12,851,000 12,496,000 10,504,000 10,418,000 7,949,000 10,139,000 10,241,000 11,504,000 16,832,000 22,536,000 20,694,000 14,021,000 19,373,000 14,464,000 16,480,000 17,220,000 13,036,000 9,927,000 11,491,000 14,043,000 8,513,000 9,118,000 10,487,000 8,598,000 3,132,000 
        total current assets
      		257,749,000 260,719,000 282,655,000 291,576,000 303,386,000 304,415,000 457,124,000 395,364,000 459,115,000 473,454,000 502,101,000 481,465,000 528,824,000 569,061,000 513,028,000 469,744,000 471,323,000 502,858,000 602,171,000 716,061,000 845,130,000 854,058,000 909,577,000 504,414,000 544,576,000 509,757,000 511,542,000 476,627,000 467,982,000 247,353,000 
        long-term investments
      		8,043,000 24,944,000 29,510,000 55,506,000 80,673,000 111,821,000  12,405,000  32,170,000 52,586,000 42,788,000 59,151,000 85,108,000 195,637,000 284,093,000 352,179,000 378,222,000 325,523,000 264,573,000 204,208,000 207,993,000 210,794,000 60,121,000 58,322,000 100,702,000 147,769,000 214,588,000 261,966,000 154,045,000 
        operating lease right-of-use asset
      		39,888,000 40,935,000 41,966,000 44,075,000 45,205,000 46,313,000 58,385,000 64,483,000 63,703,000 78,643,000 80,314,000 81,964,000 83,592,000 85,245,000 86,837,000 57,057,000 58,030,000 38,764,000 39,474,000 40,189,000 41,295,000 41,557,000 42,432,000 43,836,000 44,495,000 31,437,000 31,880,000 32,394,000 33,015,000 24,996,000 
        property and equipment
      		72,839,000 75,896,000 78,858,000 82,992,000 86,056,000 88,989,000 92,080,000 95,931,000 99,478,000 102,826,000 106,386,000 109,849,000 112,839,000 114,442,000 117,216,000 120,200,000 122,990,000 125,883,000 125,459,000 123,146,000 118,840,000 102,653,000 84,605,000 66,349,000 56,449,000 45,943,000 35,817,000 20,426,000 8,595,000 4,693,000 
        deposit placed in escrow
      		23,479,000 23,472,000 23,484,000 21,641,000 20,773,000 22,320,000 21,429,000                        
        restricted cash
      		10,292,000 10,292,000 10,292,000 10,292,000 10,292,000 10,292,000 10,292,000 10,292,000 10,292,000 10,292,000 10,292,000 10,292,000 10,292,000 10,292,000 10,292,000 10,292,000 10,292,000 9,449,000 9,449,000 9,449,000 9,449,000 9,449,000 4,299,000 4,299,000 4,299,000 4,299,000 4,299,000 4,299,000 1,299,000 937,000 
        other long-term assets
      		3,615,000 3,513,000 3,828,000 1,900,000 2,325,000 4,970,000 6,439,000 5,159,000 6,604,000 9,576,000 9,382,000 9,389,000 9,564,000 9,378,000 8,938,000 9,042,000 5,815,000 6,160,000 5,829,000 6,275,000 5,169,000 2,274,000 2,160,000 4,675,000 4,618,000 3,105,000 2,238,000 432,000 244,000 2,307,000 
        total assets
      		415,905,000 439,771,000 470,593,000 507,982,000 548,710,000 589,120,000 646,883,000 586,350,000 642,837,000 712,326,000 770,971,000 746,871,000 817,079,000 887,572,000 947,644,000 964,632,000 1,038,634,000 1,079,246,000 1,126,724,000 1,179,044,000 1,227,829,000 1,222,500,000 1,258,544,000 688,523,000 717,802,000 695,544,000 733,997,000 749,369,000 773,855,000 435,235,000 
        liabilities and stockholders’ equity
      		                              
        current liabilities:
      		                              
        accounts payable
      		4,270,000 3,699,000 4,851,000 5,058,000 5,394,000 5,506,000 12,936,000 5,779,000 5,897,000 6,205,000 10,229,000 14,688,000 13,890,000 11,045,000 9,713,000 8,708,000 10,255,000 11,499,000 11,005,000 14,875,000 10,390,000 10,151,000 9,057,000 7,199,000 9,250,000 8,047,000 23,503,000 12,976,000 12,338,000 3,083,000 
        accrued and other current liabilities
      		28,244,000 28,134,000 26,824,000 24,964,000 30,129,000 27,065,000 24,369,000 25,029,000 31,096,000 31,195,000 44,263,000 44,624,000 39,743,000 36,938,000 34,360,000 27,763,000 37,496,000 41,626,000 34,688,000 39,735,000 44,938,000 39,979,000 31,838,000 19,619,000 23,829,000 25,307,000 14,497,000 14,289,000 17,121,000 16,779,000 
        total current liabilities
      		32,514,000 31,833,000 31,675,000 30,022,000 35,523,000 32,571,000 37,305,000 30,894,000 37,079,000 37,636,000 54,721,000 59,585,000 54,518,000 48,872,000 44,909,000 36,877,000 48,174,000 53,490,000 45,998,000 54,849,000 94,320,000 50,130,000 40,895,000 26,818,000 33,079,000 33,354,000 38,000,000 27,265,000 29,459,000 159,477,000 
        lease liability, noncurrent
      		75,045,000 77,134,000 79,241,000 81,292,000 83,247,000  86,989,000 88,916,000 88,346,000    95,122,000    69,929,000    50,809,000 50,846,000 51,067,000 51,536,000 51,349,000 37,689,000 34,867,000 34,811,000 34,456,000 25,661,000 
        other long-term liabilities
      		15,804,000 15,475,000 15,116,000 11,275,000 7,761,000 7,666,000 7,551,000 5,173,000 5,179,000 1,486,000 1,523,000 1,510,000 1,569,000 2,033,000 2,554,000 3,490,000 4,125,000 5,175,000 5,705,000 2,791,000 3,083,000 2,793,000 3,163,000 3,650,000 4,351,000 4,785,000 5,495,000 6,065,000 6,776,000 7,488,000 
        total liabilities
      		123,363,000 124,442,000 126,032,000 122,589,000 126,531,000 125,372,000 131,845,000 124,983,000 130,604,000 129,224,000 148,065,000 154,609,000 151,209,000 147,611,000 145,695,000 109,402,000 122,228,000 109,304,000 102,912,000 109,265,000 148,212,000 103,769,000 95,125,000 82,004,000 88,779,000 75,828,000 78,362,000 68,141,000 70,691,000 192,626,000 
        commitments and contingencies
      		                              
        stockholders’ equity:
      		                              
        preferred stock, 0.001 par value: 10,000,000 authorized as of december 31, 2025 and december 31, 2024; no shares were issued and outstanding as of december 31, 2025 and december 31, 2024
      		                              
        common stock
      		229,000 223,000 220,000 219,000 212,000 210,000 209,000 170,000 169,000 168,000 167,000 146,000 144,000 144,000 144,000 143,000 142,000 142,000 142,000 141,000 140,000 140,000 139,000 125,000 124,000 122,000 122,000 121,000 121,000 31,000 
        additional paid-in capital
      		2,302,753,000 2,286,770,000 2,274,885,000 2,264,687,000 2,241,879,000 2,223,265,000 2,209,200,000 2,089,357,000 2,075,252,000 2,059,333,000 2,039,263,000 1,932,734,000 1,911,632,000 1,893,908,000 1,871,262,000 1,847,534,000 1,822,179,000 1,798,678,000 1,774,298,000 1,749,097,000 1,725,552,000 1,695,411,000 1,673,026,000 1,055,386,000 1,023,876,000 952,820,000 937,709,000 922,816,000 914,265,000 12,693,000 
        accumulated deficit
      		-2,010,709,000 -1,971,899,000 -1,930,499,000 -1,879,556,000 -1,819,823,000 -1,759,884,000 -1,693,591,000 -1,627,233,000 -1,562,233,000 -1,473,988,000 -1,412,673,000 -1,334,684,000 -1,235,980,000 -1,141,133,000 -1,057,985,000 -983,198,000 -903,348,000 -828,480,000 -750,294,000 -679,358,000 -646,343,000 -577,773,000 -511,576,000 -450,602,000 -396,122,000 -335,092,000 -284,357,000 -243,114,000 -211,528,000 -181,019,000 
        accumulated other comprehensive gain
      		269,000                              
        total stockholders’ equity
      		292,542,000 315,329,000 344,561,000 385,393,000 422,179,000 463,748,000 515,038,000 461,367,000 512,233,000 583,102,000 622,906,000 592,262,000 665,870,000 739,961,000 801,949,000 855,230,000 916,406,000 969,942,000 1,023,812,000 1,069,779,000 1,079,617,000 1,118,731,000 1,163,419,000 606,519,000 629,023,000 619,716,000 655,635,000 681,228,000 703,164,000  
        total liabilities and stockholders’ equity
      		415,905,000 439,771,000 470,593,000 507,982,000 548,710,000 589,120,000 646,883,000 586,350,000 642,837,000 712,326,000 770,971,000 746,871,000 817,079,000 887,572,000 947,644,000 964,632,000 1,038,634,000 1,079,246,000 1,126,724,000 1,179,044,000 1,227,829,000 1,222,500,000 1,258,544,000 688,523,000 717,802,000 695,544,000 733,997,000 749,369,000   
        preferred stock, 0.001 par value: 10,000,000 shares authorized as of september 30, 2025 and december 31, 2024; no shares were issued and outstanding as of september 30, 2025 and december 31, 2024
      		                              
        accumulated other comprehensive loss
      		 235,000 -45,000  -89,000  -780,000 -927,000 -955,000 -2,411,000 -3,851,000 -5,934,000 -9,926,000 -12,958,000 -11,472,000               -148,000 
        preferred stock, 0.001 par value: 10,000,000 shares authorized as of june 30, 2025 and december 31, 2024; no shares were issued and outstanding as of june 30, 2025 and december 31, 2024
      		                              
        preferred stock, 0.001 par value: 10,000,000 shares authorized as of march 31, 2025 and december 31, 2024; no shares were issued and outstanding as of march 31, 2025 and december 31, 2024
      		                              
        accumulated other comprehensive income
      		   43,000  157,000           -2,567,000 -398,000 -334,000 -101,000 268,000 953,000 1,830,000 1,610,000 1,145,000 1,866,000 2,161,000 1,405,000 306,000  
        equity method investments
      		      1,134,000 2,716,000 3,645,000                      
        preferred stock, 0.001 par value: 10,000,000 authorized as of december 31, 2024 and december 31, 2023; no shares were issued and outstanding as of december 31, 2024 and december 31, 2023
      		                              
        operating lease liability, noncurrent
      		     85,135,000                         
        preferred stock, 0.001 par value: 10,000,000 shares authorized as of september 30, 2024 and december 31, 2023; no shares were issued and outstanding as of september 30, 2024 and december 31, 2023
      		                              
        preferred stock, 0.001 par value: 10,000,000 shares authorized as of june 30, 2024 and december 31, 2023; no shares were issued and outstanding as of june 30, 2024 and december 31, 2023
      		                              
        deferred revenue
      		       86,000 86,000 236,000 229,000 273,000 885,000 889,000 836,000 406,000 423,000 365,000 305,000 239,000 38,992,000          
        preferred stock, 0.001 par value: 10,000,000 shares authorized as of march 31, 2024 and december 31, 2023; no shares were issued and outstanding as of march 31, 2024 and december 31, 2023
      		                              
        preferred stock, 0.001 par value: 10,000,000 authorized as of december 31, 2023 and december 31, 2022; no shares were issued and outstanding as of december 31, 2023 and december 31, 2022
      		                              
        equity method investment
      		         5,365,000 9,910,000 11,124,000 12,817,000 14,046,000 15,696,000 14,204,000 18,005,000 17,910,000 18,819,000 19,351,000 3,738,000 4,516,000 4,677,000 4,829,000 4,892,000      
        lease liability, non-current
      		         90,102,000 91,821,000 93,514,000  96,706,000 98,232,000 69,035,000  50,639,000 51,209,000 51,625,000           
        preferred stock, 0.001 par value: 10,000,000 shares authorized as of september 30, 2023 and december 31, 2022; no shares were issued and outstanding as of september 30, 2023 and december 31, 2022
      		                              
        preferred stock, 0.001 par value: 10,000,000 shares authorized as of june 30, 2023 and december 31, 2022; no shares were issued and outstanding as of june 30, 2023 and december 31, 2022
      		                              
        preferred stock, 0.001 par value: 10,000,000 shares authorized as of march 31, 2023 and december 31, 2022; no shares were issued and outstanding as of march 31, 2023 and december 31, 2022
      		                              
        preferred stock, 0.001 par value: 10,000,000 authorized as of december 31, 2022 and december 31, 2021; no shares were issued and outstanding as of december 31, 2022 and december 31, 2021
      		                              
        preferred stock, 0.001 par value: 10,000,000 shares authorized as of september 30, 2022 and december 31, 2021; no shares were issued and outstanding as of september 30, 2022 and december 31, 2021
      		                              
        preferred stock, 0.001 par value: 10,000,000 shares authorized as of june 30, 2022 and december 31, 2021; no shares were issued and outstanding as of june 30, 2022 and december 31, 2021
      		                              
        preferred stock, 0.001 par value: 10,000,000 shares authorized as of march 31, 2022 and december 31, 2021; no shares were issued and outstanding as of march 31, 2022 and december 31, 2021
      		                              
        accumulated other comprehensive
      		               -9,249,000               
        preferred stock, 0.001 par value: 10,000,000 authorized as of december 31, 2021 and december 31, 2020; no shares were issued and outstanding as of december 31, 2021 and december 31, 2020
      		                              
        preferred stock, 0.001 par value: 10,000,000 shares authorized as of september 30, 2021 and december 31, 2020; no shares were issued and outstanding as of september 30, 2021 and december 31, 2020
      		                              
        preferred stock, 0.001 par value: 10,000,000 shares authorized as of june 30, 2021 and december 31, 2020; no shares were issued and outstanding as of june 30, 2021 and december 31, 2020
      		                              
        preferred stock, 0.001 par value: 10,000,000 shares authorized as of march 31, 2021 and december 31, 2020; no shares were issued and outstanding as of march 31, 2021 and december 31, 2020
      		                              
        intangible assets
      		                        151,000 301,000 452,000 603,000 754,000 904,000 
        liabilities, convertible preferred stock and stockholders’ equity
      		                              
        preferred stock, 0.001 par value: 10,000,000 authorized as of december 31, 2020 and december 31, 2019; no shares were issued and outstanding as of december 31, 2020 and december 31, 2019
      		                              
        preferred stock, 0.001 par value: 10,000,000 shares authorized as of september 30, 2020 and december 31, 2019; no shares were issued and outstanding as of september 30, 2020 and december 31, 2019
      		                              
        preferred stock, 0.001 par value: 10,000,000 shares authorized as of june 30, 2020 and december 31, 2019; no shares were issued and outstanding as of june 30, 2020 and december 31, 2019
      		                              
        preferred stock, 0.001 par value: 10,000,000 shares authorized as of march 31, 2020 and december 31, 2019; no shares were issued and outstanding as of march 31, 2020 and december 31, 2019
      		                              
        preferred stock, 0.001 par value: 10,000,000 authorized as of december 31, 2019 and december 31, 2018, respectively; no shares were issued and outstanding as of december 31, 2019 and december 31, 2018
      		                              
        preferred stock, 0.001 par value: 10,000,000 shares authorized as of september 30, 2019 and december 31, 2018; no shares were issued and outstanding as of september 30, 2019 and december 31, 2018
      		                              
        preferred stock, 0.001 par value: 10,000,000 shares authorized as of june 30, 2019 and december 31, 2018; no shares were issued and outstanding as of june 30, 2019 and december 31, 2018
      		                              
        preferred stock, 0.001 par value: 10,000,000 shares authorized as of march 31, 2019 and december 31, 2018; no shares were issued and outstanding as of march 31, 2019 and december 31, 2018
      		                              
        convertible preferred stock, 0.001 par value...
      		                             411,052,000 
        stockholders’ equity
      		                              
        preferred stock, 0.001 par value: 10,000,000 and no shares authorized as of december 31, 2018 and december 31, 2017, respectively; no shares were issued and outstanding as of december 31, 2018
      		                              
        notes receivable from common stockholders
      		                              
        total liabilities, convertible preferred stock and stockholders’ equity
      		                            773,855,000  
        liabilities, convertible preferred stock and stockholders’ deficit
      		                              
        convertible notes payable
      		                             139,615,000 
        stockholders’ deficit:
      		                              
        total stockholders’ deficit
      		                             -168,443,000 
        total liabilities, convertible preferred stock and stockholders’ deficit
      		                             435,235,000 
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 
                                     
          cash flows from operating activities:
        		                             
          net loss
        		-38,810,000 -41,400,000 -50,943,000 -59,733,000 -59,939,000 -66,293,000 -66,358,000 -65,000,000 -89,257,000 -61,315,000 -77,989,000 -98,704,000 -94,847,000 -83,148,000 -74,787,000 -79,850,000 -74,868,000 -78,186,000 -70,936,000 -33,015,000 -68,570,000 -66,197,000 -60,974,000 -54,480,000 -61,030,000 -50,735,000 -41,243,000 -31,586,000 -30,509,000 
          adjustments to reconcile net loss to net cash from operating activities:
        		                             
          stock-based compensation
        		8,130,000 8,652,000 8,685,000 12,175,000 12,873,000 13,387,000 13,559,000 11,924,000 15,233,000 15,354,000 16,594,000 18,770,000 17,246,000 21,148,000 22,891,000 22,315,000 22,036,000 20,856,000 21,134,000 16,792,000 16,453,000 17,823,000 16,770,000 14,215,000 13,874,000 12,835,000 11,487,000 7,867,000 5,871,000 
          depreciation and amortization
        		3,057,000 3,097,000 3,106,000 3,099,000 3,233,000 3,207,000 3,644,000 3,555,000 3,477,000 3,572,000 3,643,000 3,507,000 3,068,000 3,860,000 3,675,000 3,692,000 4,242,000 2,330,000 1,964,000 1,918,000 1,844,000 1,810,000 1,888,000 1,893,000 1,704,000 1,177,000 999,000 544,000 397,000 
          net amortization/accretion on investment securities
        		-821,000 -923,000 -1,171,000 -1,306,000   -2,201,000 -2,797,000 -3,299,000 -2,944,000 -1,074,000 508,000 156,000 495,000 908,000 1,332,000 1,594,000 1,615,000 1,835,000 1,911,000 1,813,000 1,417,000 227,000 -207,000 -460,000 -851,000 -1,062,000 -1,223,000 -1,161,000 
          impairment of long-lived asset
        		                             
          impairment of equity investment and equity method investment
        		                             
          non-cash rent expense
        		1,047,000 1,031,000 1,147,000 1,130,000 1,116,000 4,299,000 -96,000 -55,000 138,000 147,000 150,000 207,000 240,000 553,000 1,174,000 466,000 -11,000 228,000 387,000 2,007,000 2,715,000 180,000 342,000 718,000 1,950,000 3,279,000 273,000 1,275,000 1,168,000 
          income tax expense
        		                             
          non-cash collaboration revenue - related party
        		    0 0 0 -14,000                      
          share of loss from equity method investments
        		      -375,000 929,000                      
          changes in operating assets and liabilities:
        		                             
          deposit placed in escrow
        		-7,000 12,000 -1,843,000 -868,000 1,547,000 -891,000                        
          prepaid expenses and other current assets
        		986,000 1,010,000 1,865,000 -623,000 1,802,000 -341,000 -1,867,000 -86,000 -2,469,000 2,190,000 102,000 1,263,000 5,328,000 5,704,000 -1,842,000 -6,673,000 5,352,000 -4,908,000 2,015,000 740,000 -3,834,000 -3,459,000 1,564,000 2,552,000 -5,531,000 607,000 1,371,000 -1,892,000 -5,466,000 
          other long-term assets
        		-102,000 315,000 -1,928,000 425,000 688,000 1,469,000 677,000 1,445,000 -1,034,000 -366,000 -100,000 45,000 -123,000 -408,000 311,000 -3,114,000 345,000 -331,000 139,000 -799,000 -1,941,000 -483,000 2,515,000 -57,000 -1,511,000 -870,000 -1,805,000 -188,000 1,224,000 
          accounts payable
        		599,000 -1,072,000 -422,000 -336,000 34,000 -7,227,000 6,808,000 -118,000 -302,000 -3,967,000 -4,290,000 1,057,000 2,938,000 1,013,000 1,422,000 -505,000 -2,044,000 189,000 -3,064,000 4,152,000 -1,066,000 2,184,000 541,000 -1,044,000 2,152,000 -4,469,000 1,680,000 -348,000 5,717,000 
          accrued and other current liabilities
        		-118,000 1,086,000 1,735,000 -5,223,000 2,880,000 2,528,000 -980,000 -5,690,000 286,000 -12,716,000 -76,000 5,686,000 3,137,000 1,946,000 5,714,000 -9,048,000 -2,768,000 8,890,000 1,844,000 -4,314,000 2,551,000 9,346,000 10,742,000 -3,913,000 -1,159,000 7,617,000 3,988,000 -4,095,000 -557,000 
          operating lease liabilities
        		-1,889,000 -1,855,000 -1,926,000 -1,833,000 -1,776,000                         
          other long-term liabilities
        		329,000 359,000 283,000 164,000 95,000 115,000 41,000 8,000 -528,000 -37,000 13,000 -59,000 -464,000 -521,000 -936,000 -635,000 -1,050,000 -530,000 2,914,000 -292,000 290,000 -370,000 -487,000 -701,000 -434,000 -709,000 -571,000 -711,000  
          net cash from operating activities
        		-27,599,000 -29,688,000 -39,030,000 -52,929,000 -36,698,000 -44,115,000 -63,588,000 -55,899,000 -53,707,000 -55,530,000 -61,857,000 -66,639,000 -62,096,000 -47,655,000 -42,531,000 -68,237,000 -45,436,000 -48,878,000 -41,170,000 -49,328,000 -9,975,000 -37,588,000 -26,721,000 -40,809,000 -50,267,000 -31,935,000 -24,892,000 -30,256,000 -21,481,000 
          capital expenditures
        		0 -243,000 -44,000 -99,000 -257,000 -429,000 0 -8,000 -181,000 -12,000 -288,000 -1,035,000 -1,692,000 -223,000 -1,374,000 -1,902,000 -736,000 -3,347,000 -10,902,000 -6,461,000 -17,404,000 -20,247,000 -16,054,000 -12,253,000 -14,112,000 -18,400,000 -7,856,000 -10,423,000 -1,321,000 
          free cash flows
        		-27,599,000 -29,931,000 -39,074,000 -53,028,000 -36,955,000 -44,544,000 -63,588,000 -55,907,000 -53,888,000 -55,542,000 -62,145,000 -67,674,000 -63,788,000 -47,878,000 -43,905,000 -70,139,000 -46,172,000 -52,225,000 -52,072,000 -55,789,000 -27,379,000 -57,835,000 -42,775,000 -53,062,000 -64,379,000 -50,335,000 -32,748,000 -40,679,000 -22,802,000 
          cash flows from investing activities:
        		                             
          purchases of property and equipment
        		0 -243,000 -44,000 -99,000 -257,000 -429,000 0 -8,000 -181,000 -12,000 -288,000 -1,035,000 -1,692,000 -223,000 -1,374,000 -1,902,000 -736,000 -3,347,000 -10,902,000 -6,461,000 -17,404,000 -20,247,000 -16,054,000 -12,253,000 -14,112,000 -18,400,000 -7,856,000 -10,423,000 -1,321,000 
          proceeds from sales of investments
        		    0    0 0 0 5,623,000         -78,000 0        
          proceeds from maturities of investments
        		61,990,000 61,912,000 53,800,000 56,500,000 102,165,000 109,801,000 117,221,000 103,272,000 136,344,000 165,158,000 152,868,000 143,441,000 99,080,000 74,582,000 117,117,000 68,680,000 82,540,000 161,772,000 215,833,000 268,249,000 221,850,000 150,144,000 101,372,000 120,261,000 116,813,000 158,350,000    
          purchase of investments
        		-28,377,000 -49,734,000 -9,921,000 -50,225,000 -46,974,000 -190,762,000 -42,608,000 -81,131,000 -68,702,000 -199,413,000 -135,420,000 -35,094,000 -47,791,000 -49,454,000 -61,709,000 -89,155,000 -50,782,000 -145,422,000 -180,327,000 -149,052,000 -182,158,000 -213,252,000 -519,166,000 -123,015,000 -89,697,000 -61,175,000 -49,359,000 -52,397,000 -333,908,000 
          net cash from investing activities
        		33,613,000 11,935,000 43,835,000 6,176,000 54,934,000 -75,992,000 74,613,000 22,133,000 67,461,000 -34,267,000 17,160,000 112,935,000 49,597,000 24,905,000 54,034,000 -22,377,000 29,250,000 13,013,000 24,594,000 96,798,000 22,210,000 -83,355,000 -428,971,000 -15,007,000 7,929,000 78,775,000 44,492,000 32,888,000 -313,388,000 
          cash flows from financing activities:
        		                             
          proceeds from issuance of common stock from atm offering, net of commissions and issuance costs
        		7,859,000 2,979,000 1,514,000 10,002,000 5,743,000 0   0 3,194,000            0        
          proceeds from issuance of common stock from public offering, net of commissions and issuance costs
        		                     32,000        
          proceeds from issuance of common stock upon exercise of stock options
        		     0 19,000 794,000  326,000    135,000 25,000 283,000  750,000 3,214,000 4,060,000  2,414,000        
          proceeds from issuance of common stock under the employee stock purchase plan
        		0 257,000 0 638,000 0 679,000 0 856,000 0 765,000 0 1,731,000 0 931,000 -1,000 1,531,000 0 1,633,000 0 1,984,000 -1,000 1,406,000 0 1,438,000      
          proceeds from cirm award
        		0 0 3,558,000 3,350,000 0 0                        
          net cash from financing activities
        		7,859,000 3,236,000 5,072,000 13,990,000 5,743,000 679,000 108,603,000 1,650,000 155,000 4,285,000 89,524,000 1,731,000 46,000 1,066,000 24,000 1,814,000 322,000 2,383,000 3,214,000 6,044,000 12,978,000 3,852,000 600,175,000 16,586,000 56,474,000 1,566,000 236,000 684,000 344,522,000 
          net decrease in cash, cash equivalents and restricted cash
        		                             
          cash, cash equivalents and restricted cash — beginning of period
        		            0 0 0 183,606,000 0 0 0 192,800,000 0 0 0 179,425,000 0 0 0 93,731,000  
          cash, cash equivalents and restricted cash — end of period
        		            -12,453,000 -21,684,000 11,527,000 94,806,000 -15,864,000 -33,482,000 -13,362,000 246,314,000 25,213,000 -117,091,000 144,483,000 140,195,000 14,136,000 48,406,000 19,836,000 97,047,000 9,653,000 
          non-cash operating, investing and financing activities:
        		                             
          right-of-use asset obtained in exchange for lease liability
        		    0 0 0 2,409,000     0 0               7,693,000 
          property and equipment purchases in accounts payable and accrued and other current liabilities
        		              -683,000 725,000 613,000 -594,000 -6,593,000 8,299,000 658,000         
          supplemental disclosure:
        		                             
          cash paid for amounts included in the measurement of lease liabilities
        		-3,236,000 -3,167,000 -3,291,000 -3,227,000 -3,197,000 -3,135,000 -3,105,000 -3,068,000 -3,036,000 -3,024,000 -3,024,000 -2,965,000 -2,935,000 -2,622,000 -2,003,000 -1,980,000 -1,955,000 -1,626,000 -1,466,000 -966,000 -10,480,000 1,420,000 1,420,000 1,396,000 -5,745,000 1,026,000 765,000 391,000  
          impairment of long-lived assets
        		 0    10,728,000                        
          proceeds from issuance of common stock from registered offering, net of commissions and issuance costs
        		     0                        
          net change in cash and cash equivalents and restricted cash
        		 -14,517,000 9,877,000 -32,763,000  -119,428,000 119,628,000 -32,116,000  -85,512,000 44,827,000 48,027,000                  
          cash and cash equivalents and restricted cash — beginning of period
        		 0 0 85,510,000  0 0 93,447,000  0 0 72,196,000                  
          cash and cash equivalents and restricted cash — end of period
        		 -14,517,000 9,877,000 52,747,000  -119,428,000 119,628,000 61,331,000  -85,512,000 44,827,000 120,223,000                  
          non-cash operating activities:
        		                             
          property and equipment purchases in accounts payable and accrued liabilities
        		 -108,000                     4,090,000 4,208,000      
          non-cash deferred revenue and other long-term liabilities
        		 0 0 3,079,000    3,079,000                      
          proceeds from issuance of common stock and upon exercise of stock options
        		                       303,000 2,255,000 467,000   -5,000 
          net increase in cash, cash equivalents and restricted cash
        		                        14,136,000 48,406,000 19,836,000 3,316,000 9,653,000 
          amortization/accretion on investment securities
        		                             
          impairment of equity method investment
        		                             
          share of gain/loss from equity method investments
        		                             
          non-cash deferred revenue included in other long-term liabilities
        		     0                        
          deferred revenue
        		        646,000 7,000 -44,000 -612,000 -4,000 53,000 430,000 -17,000 58,000 60,000 66,000 -38,753,000          
          purchase of stock in equity method investment
        		                -1,772,000 0 0 -15,938,000          
          capitalized cloud computing costs included in accounts payable and accrued and other current liabilities
        		              209,000 111,000    277,000          
          cash received for amounts related to tenant improvement allowances from lessors
        		                             
          share of loss from, and impairment of, equity method investment
        		                             
          non-cash investing activities:
        		                             
          cash received for amounts related to tenant improvement allowances
        		             0 0 325,000  0 0 1,111,000  704,000 1,085,000 532,000      
          share of loss from equity method investment
        		          1,214,000 1,693,000  1,650,000 -1,491,000 3,800,000              
          amortization of other intangible assets acquired
        		                    0 0 0 151,000 151,000 151,000 150,000 151,000 150,000 
          share of losses from equity method investments
        		                1,678,000 909,000 532,000 325,000 778,000 161,000 151,000 64,000      
          net change in cash, cash equivalents and restricted cash
        		             -21,684,000 11,527,000 -88,800,000  -33,482,000 -13,362,000 53,514,000  -117,091,000 144,483,000 -39,230,000      
          income tax benefit
        		                             
          deferred offering costs included in accounts payable and accrued and other current liabilities
        		                            -1,032,000 
          proceeds (loss) from sales of investments
        		                             
          acquired in-process research and development
        		                            0 
          change in fair value of convertible notes payable
        		                            1,796,000 
          debt issuance costs on convertible notes payable
        		                            0 
          other
        		                             
          cash paid for acquisition of assets
        		                            0 
          proceeds from issuance of convertible preferred stock, net of issuance costs
        		                            -1,000 
          proceeds from issuance of convertible notes, net of issuance costs
        		                            0 
          proceeds from early exercise of stock options
        		                             
          proceeds from issuance of common stock, net of commissions and issuance costs
        		                       14,845,000      
          common stock issued on conversion of convertible preferred stock
        		                             
          common stock issued on conversion of convertible notes payable
        		                             
          series a-1 convertible preferred stock issued in asset acquisition
        		                            0 
          pp&e and other assets acquired in asset acquisition
        		                             
          benefit from income taxes
        		                             
          acquired in process-research and development
        		                             
          deferred income taxes
        		                         33,000 -159,000 -50,000  
          payments of deferred offering costs
        		                             
          proceeds from employee stock purchase plan
        		                         1,099,000 0 684,000  
          non-cash investing and financing activities:
        		                             
          property and equipment purchase in accounts payable and accrued liabilities
        		                         -7,096,000 8,533,000 5,134,000  
          subscriptions receivable from preferred shareholders
        		                             
          vesting of early exercised options
        		                             
          proceeds from sales or maturities of investments
        		                           95,708,000  
          proceeds from issuance of common stock, net of issuance costs