7Baggers

XOMA Corporation
(NASDAQ:XOMA) 

XOMA stock logo

XOMA Corporation, a biotech royalty aggregator, discovers and develops therapeutic candidates in the United States, Europe, and the Asia Pacific. The company has a pipeline of monoclonal antibodies and technologies to license to pharmaceutical and biotechnology companies to further their clinical de...

Founded: 1981
Full Time Employees: 11
Sector: Healthcare
Industry: Biotechnology

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Quarterly
Annual
    Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 2009-12-31 2009-09-30 2009-06-30 2009-03-31 2008-12-31 2008-09-30 2008-06-30 2008-03-31 2007-12-31 2007-09-30 2007-06-30 2007-03-31 2006-12-31 2006-09-30 2006-06-30 2006-03-31 2005-12-31 2005-09-30 2005-06-30 2005-03-31 2004-12-31 2004-09-30 2004-06-30 2004-03-31 2003-12-31 
                                                                                              
      income and revenues:
                                                                                              
      income from purchased receivables under the eir method
    9,239,000 7,706,000 6,962,000 6,007,000 6,070,000                                                                                      
      income from purchased receivables under the cost recovery method
    2,769,000 4,619,000 1,857,000 1,743,000 5,525,000                                                                                      
      revenue from contracts with customers
     1,100,000 225,000 5,025,000 4,000,000 600,000 25,000 5,025,000 1,000,000 1,300,000 225,000 1,125,000  850,000 25,000 525,000 2,750,000 35,424,000 550,000 525,000 19,000 27,188,000 200,000 53,000 500,000 100,000 8,525,000 625,000 8,026,000 1,550,000 775,000 2,341,000 401,000                                                          
      revenue recognized under units-of-revenue method
    310,000 332,000 307,000 354,000 317,000 1,742,000 709,000 629,000 490,000 533,000 605,000 533,000 437,000 636,000 426,000 458,000 357,000 521,000 390,000 376,000 356,000 393,000 357,000 391,000 304,000 322,000 330,000 337,000 105,000 135,000 121,000 -86,000 62,000                                                          
      total income and revenues
    12,318,000 13,757,000 9,351,000 13,129,000 15,912,000 8,714,000 7,197,000 11,086,000                                                                                   
      operating expenses:
                                                                                              
      research and development
    49,000 281,000 69,000 69,000 1,293,000 864,000 817,000 1,161,000 33,000 25,000 25,000 39,000 54,000 28,000 29,000 40,000 56,000 42,000 30,000 38,000 61,000 36,000 34,000 38,000 62,000 130,000 143,000 724,000 256,000 237,000 637,000 376,000 432,000 660,000 307,000 2,916,000 3,993,000 8,248,000 8,674,000 13,703,000 13,610,000 13,597,000 17,559,000 19,692,000 20,004,000 19,377,000 20,235,000 19,590,000 21,546,000 22,946,000 18,198,000 17,049,000 16,590,000 15,732,000 18,381,000 18,441,000 15,771,000 16,658,000 15,851,000 18,281,000 17,347,000 14,569,500 21,345,000 19,346,000 17,587,000 14,659,000 13,444,000 13,507,000 16,521,000 20,132,000 19,714,000 23,519,000 19,211,000 18,351,000 14,620,000 17,315,000 15,929,000 15,138,000 12,671,000 12,104,000 12,181,000 10,964,000 9,383,000 9,547,000 10,002,000 11,345,000 12,562,000 12,862,000 13,015,000  
      general and administrative
    11,857,000 10,410,000 9,734,000 7,802,000 8,146,000 6,993,000 8,020,000 11,004,000 8,461,000 7,265,000 6,368,000 5,777,000 6,196,000 7,571,000 4,794,000 5,710,000 5,116,000 5,538,000 4,255,000 3,927,000 6,741,000 3,673,000 3,212,000 3,557,000 6,358,000 4,293,000 5,821,000 4,949,000 5,939,000 4,327,000 4,657,000 4,411,000 5,168,000 6,712,000 7,255,000 5,203,000 5,167,000                                 5,161,000 6,724,000 6,388,000 5,872,000 5,517,000 5,803,000 4,352,000 4,909,000 4,460,000 4,189,000 4,386,000 5,053,000 4,095,000 3,243,000 3,709,000 3,751,000 4,066,000 4,015,000 3,588,000 3,935,000  
      amortization of intangible assets
    892,000 884,000 878,000 655,000 544,000     224,000 224,000 224,000 225,000                                                                              
      total operating expenses
    12,798,000 11,575,000 10,681,000 8,526,000 9,983,000 15,967,000 22,837,000 21,165,000 8,494,000 21,767,000 6,617,000 7,615,000 10,607,000 7,696,000 4,823,000 5,750,000 5,172,000 5,580,000 4,285,000 3,965,000 6,802,000 3,709,000 3,246,000 3,595,000 6,420,000 4,423,000 5,964,000 5,673,000 6,195,000 5,107,000 6,203,000 5,246,000 5,600,000 7,368,000 7,533,000 9,579,000 11,180,000 17,983,000 12,727,000 18,461,000 17,951,000 19,442,000 25,752,000 24,752,000 25,224,000 23,475,000 25,589,000 24,750,000 26,884,000 28,113,000 23,535,000 21,230,000 20,777,000 20,010,000 23,404,000 22,765,000 24,227,000 21,893,000 23,147,000 24,394,000 22,716,000 18,763,500 27,542,000 24,372,000 23,140,000 19,423,000 20,643,000 19,474,000 25,930,000                      
      income from operations
    -480,000 2,182,000 -1,330,000 4,603,000 5,929,000 -7,253,000 -15,640,000 -10,079,000 -7,004,000 -19,934,000 -5,787,000 -5,957,000 -10,170,000 -6,210,000 -4,372,000 -4,767,000 -2,065,000 30,365,000 -3,345,000 -3,064,000 -6,427,000 23,872,000 -2,689,000 -3,151,000 -5,616,000 -4,001,000 2,891,000 -4,711,000 1,936,000 -3,422,000 -5,307,000 -2,991,000 -5,137,000 -2,011,000 28,650,000 1,311,000 -10,920,000 -17,459,000 -12,092,000 -18,018,000 -13,989,000 28,741,000 -23,678,000 -22,213,000 -22,573,000 -19,127,000 -20,453,000 -18,777,000 -23,474,000 -15,579,000 -17,223,000 -14,079,000 -11,324,000 -12,618,000 -16,153,000 -13,490,000 -14,362,000 -12,046,000 -6,918,000 -7,869,000 -7,121,000 -16,091,000 -16,645,000 -18,430,000 -15,938,000 2,174,000 6,780,000 -9,768,000 13,774,000 11,627,000 -18,544,000 -18,791,000 -13,026,000 -9,144,000 22,717,000 -7,531,000 -8,586,000 -10,571,000 -9,505,000 -8,978,000 -11,630,000 -8,968,000 -8,200,000 -8,097,000 -10,760,000 -17,340,000 -19,875,000 -20,863,000 -20,018,000  
      yoy
    -108.10% -130.08% -91.50% -145.67% -184.65% -63.61% 170.26% 69.20% -31.13% 221.00% 32.37% 24.96% 392.49% -120.45% 30.70% 55.58% -67.87% 27.20% 24.40% -2.76% 14.44% -696.65% -193.01% -33.11% -390.08% 16.92% -154.48% 57.51% -137.69% 70.16% -118.52% -328.15% -52.96% -88.48% -336.93% -107.28% -21.94% -160.75% -48.93% -18.89% -38.03% -250.26% 15.77% 18.30% -3.84% 22.77% 18.75% 33.37% 107.29% 23.47% 6.62% 4.37% -21.15% 4.75% 133.49% 71.43% 101.69% -25.14% -58.44% -57.30% -55.32% -840.16% -345.50% 88.68% -215.71% -81.30% -136.56% -48.02% -205.74% -227.15% -181.63% 149.52% 51.71% -13.50% -339.00% -16.12% -26.17% 17.87% 15.91% 10.88% 8.09% -48.28% -58.74% -61.19% -46.25%      
      qoq
    -122.00% -264.06% -128.89% -22.36% -181.75% -53.63% 55.17% 43.90% -64.86% 244.46% -2.85% -41.43% 63.77% 42.04% -8.29% 130.85% -106.80% -1007.77% 9.17% -52.33% -126.92% -987.76% -14.66% -43.89% 40.36% -238.40% -161.37% -343.34% -156.58% -35.52% 77.43% -41.78% 155.45% -107.02% 2085.35% -112.01% -37.45% 44.38% -32.89% 28.80% -148.67% -221.38% 6.60% -1.59% 18.02% -6.48% 8.93% -20.01% 50.68% -9.55% 22.33% 24.33% -10.26% -21.88% 19.74% -6.07% 19.23% 74.13% -12.09% 10.50% -55.75% -3.33% -9.69% 15.64% -833.12% -67.94% -169.41% -170.92% 18.47% -162.70% -1.31% 44.26% 42.45% -140.25% -401.65% -12.29% -18.78% 11.22% 5.87% -22.80% 29.68% 9.37% 1.27% -24.75% -37.95% -12.75% -4.74% 4.22%   
      operating margin %
    -Infinity% Infinity% -Infinity% Infinity% Infinity% -Infinity% -Infinity% -Infinity% -470.07% -1087.51% -697.23% -359.29% -2327.23% -417.90% -969.40% -484.94% -66.46% 84.48% -355.85% -340.07% -1713.87% 86.55% -482.76% -709.68% -698.51% -948.10% 32.65% -489.71% 23.81% -203.09% -592.30% -132.64% -1109.50% -37.54% 79.18% 12.04% -4200.00% -3331.87% -1904.25% -4067.27% -353.08% 59.65% -1141.66% -874.87% -851.49% -439.90% -398.23% -314.36% -688.39% -124.29% -272.86% -196.88% -119.79% -170.70% -222.77% -145.44% -145.59% -122.33% -42.63% -47.62% -45.66% -167.61% -152.75% -310.16% -221.30% 10.07% 24.72% -100.64% 34.69% 31.49% -234.91% -169.04% -108.04% -62.10% 52.66% -53.28% -70.08% -117.10% -129.23% -119.52% -207.53% -147.23% -185.27% -156.95% -359.51% -803.52% -3555.46% -2681.62% -11775.29%  
      other income, net:
                                                                                              
      gains on acquisitions
    3,545,000 3,220,000 18,004,000                                                                                        
      interest expense
    -3,359,000 -3,027,000 -3,301,000 -3,236,000 -3,467,000 -3,394,000 -3,493,000 -3,402,000 -3,551,000           -172,000 -289,000 -360,000 -434,000 -508,000 -542,000 -583,000 -484,000 -423,000 -429,000 -365,000 -209,000 -178,000 -170,000 -130,000 -202,000 -297,000 -609,000 -955,000 -982,000 -1,007,000 -1,002,000 -1,042,000 -1,030,000 -1,007,000 -1,115,000 -1,008,000 -1,060,000 -1,110,000 -1,125,000 -1,136,000 -1,159,000 -1,164,000 -1,172,000 -1,176,000 -1,144,000 -1,025,000 -1,042,000 -454,500 -652,000 -634,000 -532,000 -70,250 -104,000 -90,000 -87,000 -110,000 -1,339,000 -1,671,000 -1,768,000 -2,042,000 -1,998,000 -2,164,000 -1,450,000 -1,227,000 -1,240,000  -7,933,000 -4,532,000 -1,655,000 2,681,000 -9,426,000 -1,240,000 -1,236,000 -1,117,000 -661,000 -304,000 -307,000 -278,000 -340,000  
      other income
    4,760,000 3,782,000 727,000 7,824,000 -95,000 1,021,000 1,890,000 2,050,000 1,960,000 394,000 278,000 557,000 357,000 219,000 194,000 97,000 -215,000 -430,000 -1,091,000 1,299,000  -821,000 2,046,000 126,000 -126,000 263,000 771,000 1,062,000 1,726,000 677,000 938,000 1,222,000 1,501,000 778,000 -263,000 -729,000 1,329,000 925,000 289,000 602,000 -306,000 4,047,000 -194,000 -363,000 2,010,000 729,000 1,393,000 27,000 -90,000   -224,000 449,000 -135,500 -420,000 542,000  955,000 1,027,000 355,000 1,323,000 -1,925,000 3,113,000 2,950,000 -5,763,000 561,000 103,000 1,134,000 3,000 -48,000 -2,000 42,000  -56,000 3,000   112,000 -5,000 -3,000 -4,000 -40,930,000 -10,000 252,000 40,932,000 9,000 -119,000 -2,000 -4,000  
      net income before tax
    4,466,000 6,157,000 14,100,000                                                                                        
      income tax expense
    -1,000 -12,250 -49,000                                                                                        
      net income
    4,465,000 6,103,000 14,051,000 9,191,000 2,367,000 -3,968,000 -17,243,000                             285,000 -10,715,000   -15,160,000 -8,365,000 25,352,000 -480,000 -23,759,000 -21,718,000 -7,318,000 -14,399,000 -11,897,000 -4,687,000 -52,299,000 -29,624,000 -17,248,000 -24,887,000 2,366,000 -26,851,000 -16,155,000 -30,425,000 -11,735,000 -6,543,000 -8,130,000 -6,335,000 -17,758,000 -13,633,000 -15,580,000 -21,785,000 2,983,000 1,538,000 -10,210,000 6,239,000 9,982,000 -20,362,000 -20,690,000 -14,175,000 -9,877,000 21,817,000 -8,338,000 -15,928,000 -14,487,000 -10,836,000 -5,915,000 -20,603,000 -9,725,000 -8,994,000 -8,582,000 30,080,000 -17,588,000 -20,143,000 -21,043,000 -20,168,000  
      yoy
    88.64% -253.81% -181.49%                                 -101.88% 28.09%   -36.19% -61.48% -446.43% -96.67% 99.71% 363.37% -86.01% -51.39% -31.02% -81.17% -2310.44% 10.33% 6.77% -18.20% -120.16% 310.38% 98.71% 380.27% -33.92% -52.01% -47.82% -70.92% -695.31% -986.41% 52.60% -449.17% -70.12% -107.55% -50.65% -144.01% -201.06% -193.33% 148.14% -11.01% -31.82% -301.34% 40.96% -22.69% 48.97% 20.48% -31.08% -168.49% -44.71% -55.35% -59.22% -249.15%      
      qoq
    -26.84% -56.57% 52.88% 288.30% -159.65% -76.99%                              -102.66%    81.23% -133.00% -5381.67% -97.98% 9.40% 196.78% -49.18% 21.03% 153.83% -91.04% 76.54% 71.75% -30.69% -1151.86% -108.81% 66.21% -46.90% 159.27% 79.35% -19.52% 28.33% -64.33% 30.26% -12.50% -28.48% -830.31% 93.95% -115.06% -263.65% -37.50% -149.02% -1.59% 45.96% 43.52% -145.27% -361.66% -47.65% 9.95% 33.69% 83.20% -71.29% 111.86% 8.13% 4.80% -128.53% -271.03% -12.68% -4.28% 4.34%   
      net income margin %
    Infinity% Infinity% Infinity% Infinity% Infinity% -Infinity% -Infinity% NaN% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 2.62% -4121.15% 0% 0% -3422.12% -211.13% 52.62% -23.14% -935.76% -819.24% -168.31% -280.35% -199.18% -137.45% -417.26% -469.33% -241.20% -263.27% 32.01% -370.31% -174.18% -308.41% -119.17% -40.32% -49.20% -40.62% -184.98% -125.11% -262.20% -302.49% 13.81% 5.61% -105.19% 15.71% 27.04% -257.94% -186.13% -117.57% -67.08% 50.57% -58.98% -130.00% -160.49% -147.33% -78.74% -367.65% -159.66% -203.21% -166.35% 1005.01% -815.01% -3603.40% -2704.76% -11863.53%  
      net income available to common stockholders
                                                                                              
      basic
    2,121,000 3,324,000 8,981,000 5,522,000 705,000   10,224,000                                                                                   
      diluted
    3,013,000 4,679,000 12,683,000 7,823,000 999,000   14,617,000                                                                                   
      net income per share
                                                                                              
      basic
    0.18 0.27 0.74 0.46 0.06 -0.45 -1.59 0.88                                                                                   
      diluted
    0.17 0.26 0.7 0.44 0.06 -0.45 -1.59 0.84                                                                                   
      weighted-average shares used for eps calculation
            11,580 11,471 11,473 11,466 11,460 11,413 11,447 11,421 11,330 11,288 11,311 11,285 11,240 10,674 11,019 10,824 9,761 8,763 8,731 8,725 8,706 8,373 8,386 8,362 8,313 7,619 7,786 7,588 6,887                                                      
      basic
    11,894 12,081 12,137 12,007 11,969 11,701 11,712 11,643                                                                                   
      diluted
    17,417 17,982 18,141 17,761 17,781 11,701 11,712 17,321                                                                                   
      credit losses on purchased receivables
                                                                                              
      change in fair value of embedded derivative related to rpa
           8,100,000                                                                                   
      net income available to
                                                                                              
      basic
    2,121,000 3,324,000 8,981,000 5,522,000 705,000   10,224,000                                                                                   
      diluted
    3,013,000 4,679,000 12,683,000 7,823,000 999,000   14,617,000                                                                                   
      gain on the acquisition of kinnate
           19,316,000                                                                                   
      income from purchased receivables
         2,973,750 6,463,000 5,432,000                                                                                   
      royalty purchase agreement asset impairment
         5,750,000 14,000,000 9,000,000  393,750  1,575,000                                                                               
      arbitration settlement costs
                4,132,000                                                                              
      other income:
                                                                                              
      net loss attributable to common stockholders
                                                                                              
      basic
         -5,336,000 -18,611,000                                                                                    
      diluted
         -5,336,000 -18,611,000                                                                                    
      net income and comprehensive income
           15,985,000              22,666,000 -1,077,000  -4,758,000 584,750 3,178,000  3,233,000 -3,012,000 -4,578,000 -1,947,000  -1,319,000 26,344,000                                                        
      revenues:
                                                                                              
      total revenues
            1,490,000 1,833,000 830,000 1,658,000 437,000 1,486,000 451,000 983,000 3,107,000 35,945,000 940,000 901,000 375,000 27,581,000 557,000 444,000 804,000 422,000 8,855,000 962,000 8,131,000 1,685,000 896,000 2,255,000 463,000 5,357,000 36,183,000 10,890,000 260,000 524,000 635,000 443,000 3,962,000 48,183,000 2,074,000 2,539,000 2,651,000 4,348,000 5,136,000 5,973,000 3,410,000 12,534,000 6,312,000 7,151,000 9,453,000 7,392,000 7,251,000 9,275,000 9,865,000 9,847,000 16,229,000 16,525,000 15,595,000 9,600,000 10,897,000 5,942,000 7,202,000 21,597,000 27,423,000 9,706,000 39,704,000 36,920,000 7,894,000 11,116,000 12,057,000 14,724,000 43,140,000 14,136,000 12,252,000 9,027,000 7,355,000 7,512,000 5,604,000 6,091,000 4,426,000 5,159,000 2,993,000 2,158,000 559,000 778,000 170,000  
      yoy
            240.96% 23.35% 84.04% 68.67% -85.93% -95.87% -52.02% 9.10% 728.53% 30.33% 68.76% 102.93% -53.36% 6435.78% -93.71% -53.85% -90.11% -74.96% 888.28% -57.34% 1656.16% -68.55% -97.52% -79.29% 78.08% 922.33% 5598.11% 2358.24% -93.44% -98.91% -69.38% -82.55% 49.45% 1008.16% -59.62% -57.49% -22.26% -65.31% -18.63% -16.47% -63.93% 69.56% -12.95% -22.90% -4.18% -24.93% -55.32% -43.87% -36.74% 2.57% 48.93% 178.11% 116.54% -55.55% -60.26% -38.78% -81.86% -41.50% 247.39% -12.68% 229.30% 150.75% -81.70% -21.36% -1.59% 63.11% 486.54% 88.18% 118.63% 48.20% 66.18% 45.61% 87.24% 182.25% 691.77% 563.11% 1660.59%      
      qoq
            -18.71% 120.84% -49.94% 279.41% -70.59% 229.49% -54.12% -68.36% -91.36% 3723.94% 4.33% 140.27% -98.64% 4851.71% 25.45% -44.78% 90.52% -95.23% 820.48% -88.17% 382.55% 88.06% -60.27% 387.04% -91.36% -85.19% 232.26% 4088.46% -50.38% -17.48% 43.34% -88.82% -91.78% 2223.19% -18.31% -4.22% -39.03% -15.34% -14.01% 75.16% -72.79% 98.57% -11.73% -24.35% 27.88% 1.94% -21.82% -5.98% 0.18% -39.32% -1.79% 5.96% 62.45% -11.90% 83.39% -17.50% -66.65% -21.24% 182.54% -75.55% 7.54% 367.70% -28.99% -7.80% -18.11% -65.87% 205.18% 15.38% 35.73% 22.73% -2.09% 34.05% -8.00% 37.62% -14.21% 72.37% 38.69% 286.05% -28.15% 357.65%   
      net loss and comprehensive loss
            -8,595,000 -20,109,000 -5,509,000 -5,400,000 -9,813,000 -2,782,000 -4,178,000 -4,670,000 -2,280,000 -3,511,500 -4,436,000 -2,237,000 -7,373,000   -3,533,000    -4,072,000     -3,806,000     -9,012,500 -12,525,000                                                    
      less: accumulated dividends on series a and series b preferred stock
            -1,368,000 -1,026,000 -1,368,000 -1,368,000 -1,368,000 -1,026,000 -1,368,000 -1,368,000 -1,368,000 -798,000 -1,368,000 -1,293,000                                                                       
      net loss and comprehensive loss attributable to common stockholders, basic and diluted
            -9,963,000 -21,477,000 -6,877,000 -6,768,000 -11,181,000                                                                              
      basic and diluted net loss per share attributable to common stockholders
            -0.86 -1.87 -0.6 -0.59 -0.98 -0.335 -0.48 -0.53                                                                           
      weighted-average shares used for eps calculation
            11,580 11,471 11,473 11,466 11,460 11,413 11,447 11,421 11,330 11,288 11,311 11,285 11,240 10,674 11,019 10,824 9,761 8,763 8,731 8,725 8,706 8,373 8,386 8,362 8,313 7,619 7,786 7,588 6,887                                                      
      loss on extinguishment of debt
                       -300,000               -135,000  -515,000                                                      
      net loss attributable to common stockholders, basic and diluted
                 -3,808,000 -5,546,000 -6,038,000                                                                           
      net loss available to common stockholders, basic and diluted
                    -3,648,000 -4,309,500 -5,804,000 -3,530,000 -7,903,000                                                                      
      basic and diluted net loss per share available to common stockholders
                    -0.32 -0.383 -0.51 -0.31 -0.7   -0.33    -0.47     -0.46    -2.37                                                      
      loss before income tax
                     -3,511,500 -4,436,000 -2,237,000 -7,373,000   -3,533,000                                                                   
      income tax benefit
                         -25,000   1,526,000                                                                  
      other expense
                        -657,000                             -289,000 -132,000      -664,000                -91,000    -10,000              
      less: series a accumulated dividends
                        -530,000                                                                      
      income before income tax
                         22,691,000 -1,077,000  -6,284,000     -3,110,000 -4,578,000   -1,363,000 28,050,000                                                        
      net income and comprehensive income available to common stockholders, basic
                         -2,342,000 -1,077,000  -4,758,000 340,500 1,851,000  1,881,000 -2,582,750 -4,578,000                                                            
      net income and comprehensive income available to common stockholders, diluted
                         -2,342,000 -1,077,000  -4,758,000 350,750 1,911,000  1,935,000 -2,582,750 -4,578,000                                                            
      basic net income per share available to common stockholders
                         1.71 -0.1  -0.49 0.04 0.21  0.22 -0.35 -0.55 -0.23  -0.14 2.06 0.02                                                       
      diluted net income per share available to common stockholders
                         1.67 -0.1  -0.49 0.038 0.2  0.21 -0.35 -0.55 -0.23  -0.15 1.98 0.02                                                       
      restructuring
                                   459,000    1,460,000 2,020,000 4,551,000  -21,000 36,000 1,138,000 2,561,000      84,000 119,000 112,000 79,000 17,000 298,000 323,000 676,000 3,777,000     11,250 45,000    2,000 312,000 3,289,000                      
      the accompanying notes are an integral part of these condensed consolidated financial statements.
                                                                                              
      restructuring charges
                                 543,000 909,000                                                            
      provision for income taxes
                                     44,000 -1,706,000                                               10,000 2,000 38,000       
      net income and comprehensive income available to common stockholders, basic and diluted
                                   -1,947,000                                                           
      deemed dividend on convertible preferred stock
                                        -5,603,000                                                      
      net loss and comprehensive loss available to common stockholders, basic and diluted
                                    -3,806,000                                                          
      license and collaborative fees
                                     11,748,250 36,068,000 10,775,000 150,000 100,000 430,000 275,000 2,491,000 47,212,000 645,000 945,000 263,000 1,068,000 2,450,000 1,201,000 964,000 8,450,000 1,574,000 605,000 399,000 1,062,000 1,127,000 2,525,000 1,014,000 1,266,000 4,859,000 6,039,000 5,827,000 437,250 1,410,000 150,000 189,000 14,546,000 1,421,000 155,000 27,700,000 14,900,000 1,286,000 155,000 25,000 601,000 31,311,000 130,000 4,418,000 825,000 636,000 731,000 654,000 1,025,000 856,000 2,655,000 525,000 2,131,000 530,000 757,000 155,000  
      contract and other
                                     39,000 115,000 115,000 110,000 424,000 205,000 168,000 1,471,000 971,000 1,429,000 1,594,000 2,388,000 3,280,000 2,686,000 4,772,000 2,446,000 4,084,000 4,738,000 6,336,000 8,796,000 5,922,000 5,905,000 6,181,000 8,851,000                                  
      restructuring charge
                                     862,750 -29,000                                                        
      revaluation of contingent warrant liabilities
                                         9,000 260,000 3,263,000 6,932,000 -6,394,000 24,422,000 -176,000 -40,000 12,088,000 5,721,000 7,963,000 20,002,000 -35,294,000 -11,125,000 -1,781,000 -12,840,000 16,574,000 -9,208,000 -2,182,000 -14,357,000                                  
      basic net income available to common stockholders
                                     1,652,250 16,038,000                                                        
      diluted net income available to common stockholders
                                     1,667,250 16,418,000                                                        
      basic and diluted net income available to common stockholders
                                       172,000                                                       
      other comprehensive income:
                                                                                              
      net unrealized loss on marketable securities
                                           -12 -42                                                  
      total comprehensive income
                                       285                                                       
      net loss available to common stockholders
                                        -16,318,000                                                      
      other comprehensive loss:
                                                                                              
      total comprehensive loss
                                        -10,715                                                      
      selling, general and administrative
                                         5,184,000 4,053,000 4,779,000 4,305,000 4,707,000 5,632,000 5,060,000 5,220,000 4,098,000 5,354,000 5,160,000 5,254,000 5,048,000 5,225,000 4,081,000 4,124,000 3,947,000 4,672,000 3,567,000 4,679,000 5,235,000 7,296,000 6,113,000 5,369,000 4,182,750 6,152,000 5,026,000 5,553,000 4,764,000 7,197,000 5,655,000 6,120,000                      
      basic and diluted net loss per share of common stock
                                         -1.5 -2.08 -0.13 -0.07        -0.04 -0.58 -0.34 -0.21 -0.3 0.12 -0.39 -0.24 -0.69                                  
      shares used in computing basic and diluted net loss per share of common stock
                                         1,502.5 6,029 120,448 119,568        106,158 2,733 87,033 82,939 82,595 4,390 68,189 68,087 44,353                                  
      comprehensive loss
                                           -15,172 -8,407 25,352 -480 -23,759 -21,718 -7,322 -14,401 -11,898 -4,680 -52,308 -29,624 -17,259 -24,884 2,362 -26,844 -16,150                                   
      basic net loss per share of common stock
                                             0.22  -0.2 -0.19 -0.07 -0.13 -0.11                                           
      diluted net loss per share of common stock
                                             0.22  -0.2 -0.19 -0.12 -0.17 -0.17                                           
      shares used in computing basic net loss per share of common stock
                                             366 118,552 117,540 116,193 667 107,208 106,927                                           
      shares used in computing diluted net loss per share of common stock
                                             366 118,552 117,540 116,193 457 114,323 114,126                                           
      net unrealized gain on available-for-sale securities
                                                 -4 -2 -1                                           
      net unrealized gains on available-for-sale securities
                                                       -4                                    
      net loss before taxes
                                                 -7,318,000 -14,399,000   -52,298,000 -29,639,000   2,366,000 -26,925,000 -16,155,000 -30,425,000 -5,248,250 -6,543,000 -8,130,000 -6,320,000                              
      provision for income tax benefit
                                                     -1,000 15,000    74,000                                    
      other expense:
                                                                                              
      net unrealized loss on available-for-sale securities
                                                       -11                                       
      net product sales
                                                       210,000 258,000 249,000 219,000 569,000                                   
      cost of sales
                                                       21,000 46,000 33,000 28,000 81,000                                   
      provision for income tax expense
                                                             -3,750   -15,000 4,250 1,000 16,000  1,520,750 370,000 -87,000 5,800,000                      
      contract and other revenue
                                                             8,560,000 11,349,000 10,467,000 9,661,000 4,506,250 5,733,000 5,481,000 6,811,000 6,830,000 3,688,000 7,576,000 7,398,000 15,745,000 1,979,000 5,638,000 7,111,000 9,527,000 7,424,000 9,747,000 4,359,000 4,741,000 3,813,000 4,681,000 3,094,000     16,250 29,000 21,000 15,000  
      royalties
                                                             21,000 21,000 19,000 107,000 1,066,750 3,754,000 311,000 202,000 221,000 22,314,000 1,975,000 4,606,000 6,275,000 4,629,000 5,323,000 4,921,000 4,596,000 4,405,000 4,259,000 3,475,000 3,461,000 2,906,000 2,100,000 1,856,000 1,724,000 1,712,000 1,571,000 1,209,000      
      basic and diluted net loss per common share
                                                             -172.5 -200 -270 -220   -60    -70    -160 -110   -60 -140         -200 -240 -250 -240  
      shares used in computing basic and diluted net loss per common share
                                                             7,655,750 32,761,000 29,889,000 29,180,000   250,431,000    150,283,000    132,288,000 132,156,000   131,694,000 116,196,000         238,000 85,284,000 84,391,000 84,171,000  
      investment and interest income
                                                               18,000 10,000 3,250 4,000 6,000 3,000 2,000 9,000 8,000 30,000 62,000 182,000 223,000 392,000 550,000 337,000 377,000 601,000 504,000 329,000 385,000 457,000 441,000 454,000 418,000 569,000 47,000 158,000 100,000 194,000  
      loss on debt extinguishment
                                                                      -3,645,000                        
      net income before taxes
                                                                 -17,748,000 -13,632,000 -15,564,000 -21,785,000 2,627,000 1,908,000 -10,297,000 12,039,000                      
      basic net income per common share
                                                                 -717.5 -690      40 -105 -150   -80 170   -100 -110 -60 -230 -120 -100 -100 350      
      diluted net income per common share
                                                                 -717.5 -690      40 -105 -150   -80 160   -100 -110 -60 -230 -100 -100 -100 280      
      shares used in computing basic net income per common share
                                                                 4,435,500 19,802,000  239,493,000 11,730,000 167,254,000  141,772,000 33,067,500 132,364,000   1,337,000 131,766,000   1,920,000 97,414,000 96,661,000 87,943,000 21,522,750 86,277,000 86,253,000 85,745,000      
      shares used in computing diluted net income per common share
                                                                 4,435,500 19,802,000  239,493,000 16,550,000 172,762,000  145,596,000 33,067,500 132,364,000   1,337,000 136,219,000   1,920,000 97,414,000 96,661,000 87,943,000 29,416,500 86,277,000 86,253,000 108,461,000      
      basic and diluted net income per common share
                                                                    -90 -5 10                        
      operating costs and expenses:
                                                                                              
      total operating costs and expenses
                                                                         25,293,000 26,438,000 29,907,000 25,083,000 23,868,000 20,423,000 21,667,000 20,838,000 19,598,000 16,860,000 16,490,000 17,234,000 15,059,000 12,626,000 13,256,000 13,753,000 19,498,000 20,434,000 21,641,000 20,188,000  
      interest income
                                                                               -1,184,000               
      net income from operations before taxes
                                                                                 -9,338,500 -10,836,000 -5,915,000           
      contract revenue
                                                                                     1,012,500 1,858,000 933,000 1,259,000      
      collaboration arrangement
                                                                                         4,087,000 3,857,000 5,191,000 3,238,000  
      income from operations before income taxes
                                                                                     3,136,000 -8,992,000 -8,544,000       
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 2009-12-31 2009-09-30 2009-06-30 2009-03-31 2008-12-31 2008-09-30 2008-06-30 2008-03-31 2007-12-31 2007-09-30 2007-06-30 2007-03-31 2006-12-31 2006-09-30 2006-06-30 2006-03-31 2005-12-31 2005-09-30 2005-06-30 2005-03-31 2004-12-31 2004-09-30 2004-06-30 2004-03-31 2003-12-31 
                                                                                                
        assets
                                                                                                
        current assets:
                                                                                                
        cash and cash equivalents
      85,600,000 82,908,000 45,189,000 75,060,000 90,265,000 101,654,000 142,050,000 143,904,000 136,225,000 153,290,000 33,472,000 31,445,000 44,300,000 57,826,000 78,285,000 83,182,000 87,796,000             45,780,000 28,433,000 38,690,000 41,968,000 43,471,000 47,747,000 12,465,000 20,045,000 25,742,000 20,618,000 33,854,000 46,153,000 65,767,000 32,046,000 50,957,000 67,491,000 78,445,000 54,060,000 65,895,000 73,706,000 101,659,000 73,988,000 57,934,000 50,379,000 45,345,000 42,199,000 54,917,000 74,887,000 48,344,000 45,707,000 51,157,000 56,874,000 37,304,000 16,860,000 12,101,000 28,417,000 23,909,000 27,726,000 27,616,000 21,561,000 9,513,000 6,186,000 20,734,000 8,815,000 22,500,000 41,770,000 17,174,000 17,513,000 28,002,000 10,517,000 11,798,000 14,715,000 20,804,000 14,584,000 55,769,000 61,679,000 23,808,000 35,930,000 53,989,000 78,538,000 84,812,000 
        short-term restricted cash
      8,862,000 5,441,000 45,288,000 80,000 1,410,000 1,330,000 80,000  160,000 160,000                                                                                 
        investment in equity securities
      494,000 382,000 1,521,000 8,801,000 2,382,000 3,529,000                                                                                     
        trade and other receivables
      4,595,000 4,896,000 3,573,000 1,817,000 5,544,000 1,839,000 1,045,000 526,000 3,000 1,004,000 43,000 901,000 6,000 1,000 16,000 5,000 25,000 209,000 518,000 12,000 80,000 263,000 222,000 411,000 1,312,000 2,933,000 3,783,000 2,577,000 2,755,000 1,468,000 1,315,000 480,000 436,000 397,000 1,026,000 10,631,000 1,343,000 566,000 756,000 959,000 1,977,000 4,069,000 39,343,000 2,649,000 3,271,000 3,309,000 3,420,000 5,510,000 4,312,000 3,781,000 5,630,000 7,293,000 6,270,000 8,249,000 7,005,000 6,386,000 10,164,000 12,332,000 14,900,000 11,059,000 10,233,000  7,944,000 8,516,000 7,792,000 7,231,000 3,203,000 6,283,000 9,289,000                      
        short-term royalty and commercial payment receivables under the eir method
      18,724,000 22,780,000 13,269,000 17,960,000 12,240,000 14,763,000                                                                                     
        prepaid expenses and other current assets
      473,000 852,000 967,000 507,000 971,000 2,076,000 2,379,000 2,820,000 270,000 483,000 776,000 799,000 456,000 725,000 997,000 1,051,000 409,000 613,000 969,000 1,144,000 218,000 443,000 671,000 849,000 205,000 352,000 519,000 619,000 268,000 378,000 423,000 588,000 273,000 327,000 318,000 334,000 264,000 852,000 1,251,000 1,070,000 1,568,000 1,887,000 2,878,000 2,117,000 1,860,000 2,088,000 2,348,000 2,129,000 2,558,000 1,630,000 3,150,000 3,193,000 3,062,000 2,256,000 2,514,000 1,423,000 3,674,000 2,019,000 1,341,000 807,000 465,000  1,486,000 1,811,000 1,219,000 1,012,000 1,331,000 1,658,000 978,000 1,296,000 1,858,000                    
        total current assets
      118,748,000 117,259,000 110,707,000 104,925,000 113,225,000 125,604,000 159,021,000 162,203,000 146,890,000 169,313,000 34,505,000 38,423,000 45,073,000 61,253,000 79,741,000 87,261,000 89,614,000 96,973,000 74,872,000 87,251,000 70,248,000 88,065,000 48,144,000 52,277,000 56,355,000 59,973,000 44,046,000 45,523,000 51,459,000 47,626,000 30,171,000 39,758,000 42,677,000 44,195,000 49,091,000 23,430,000 21,652,000 27,160,000 22,625,000 36,325,000 50,152,000 72,219,000 74,267,000 55,723,000 72,622,000 83,842,000 64,828,000 83,532,000 100,572,000 127,060,000 82,768,000 68,420,000 79,707,000 95,837,000 68,714,000 74,719,000 88,725,000 62,695,000 61,948,000 63,023,000 67,572,000  26,290,000 22,428,000 37,428,000 32,152,000 32,260,000 42,791,000 47,325,000 38,704,000 34,663,000 49,944,000 29,323,000 58,088,000 64,789,000 42,975,000 46,028,000 65,888,000 31,850,000 42,244,000 45,347,000 50,288,000 52,262,000 62,320,000 65,176,000 26,607,000 38,228,000 55,736,000 80,352,000 97,234,000 
        long-term restricted cash
      44,281,000 45,361,000 40,076,000 3,345,000 3,352,000 3,432,000 4,686,000 6,016,000 6,016,000 6,100,000            531,000                                                                     
        property and equipment
      18,000 21,000 24,000 26,000 29,000 32,000 34,000 37,000 40,000 25,000 5,000 5,000 6,000 7,000 8,000 10,000 12,000 13,000 15,000 17,000 19,000 21,000 24,000 22,000 28,000 34,000 40,000 46,000 53,000 59,000 66,000 74,000 75,000 83,000 97,000 234,000 396,000 1,036,000 1,402,000 1,577,000 1,793,000 1,997,000 4,097,000 4,455,000 4,783,000 5,120,000 5,286,000 5,595,000 6,028,000 6,456,000 6,917,000 7,308,000 7,861,000 8,143,000 8,793,000 9,316,000 10,329,000 12,709,000 13,357,000 14,410,000 14,401,000  16,179,000 17,556,000 18,865,000 20,270,000 21,794,000 23,592,000 25,206,000 26,843,000 27,970,000 27,757,000 26,146,000 25,603,000 24,345,000 23,230,000 22,818,000 22,434,000 22,144,000 21,940,000 21,304,000 19,056,000 18,549,000 18,547,000 18,496,000 19,306,000 20,475,000 20,587,000 20,981,000 21,337,000 
        operating lease right-of-use assets
      239,000 256,000 272,000 288,000 304,000 319,000 335,000 349,000 364,000 378,000  17,000 67,000 29,000 73,000 116,000 158,000 200,000 240,000 281,000 320,000 359,000 398,000 436,000 473,000 510,000 5,929,000 6,417,000 6,906,000                                                              
        long-term royalty and commercial payment receivables under the eir method
      4,235,000 4,433,000 4,678,000 4,775,000 4,857,000 4,970,000                                                                                     
        long-term royalty and commercial payment receivables under the cost recovery method
      55,886,000 55,888,000 57,864,000 58,937,000 59,916,000 55,936,000                                                                                     
        exarafenib milestone asset
      3,704,000 3,600,000 3,500,000 3,402,000 3,307,000 3,214,000 3,125,000 2,922,000                                                                                   
        investment in warrants
      709,000 697,000 595,000 609,000 605,000                                                                                      
        intangible assets
      43,864,000 44,756,000 44,556,000 45,434,000 25,365,000 25,909,000     14,477,000 14,701,000 14,925,000 15,150,000                                                                             
        other assets - long term
      174,000 427,000 879,000 1,715,000 1,790,000 1,861,000 1,932,000 2,022,000 533,000 533,000 411,000 283,000 260,000 260,000 260,000 260,000 301,000 301,000                                                                         
        total assets
      271,858,000 272,698,000 263,151,000 223,456,000 212,750,000 221,277,000 223,340,000 243,280,000 219,420,000 234,301,000 124,094,000 125,661,000 133,664,000 140,382,000 146,131,000 154,222,000 159,160,000 166,562,000 130,503,000 135,752,000 119,893,000 125,285,000 85,728,000 87,856,000 91,790,000 95,724,000 86,095,000 78,334,000 75,734,000 63,785,000 46,162,000 41,216,000 43,311,000 44,935,000 49,710,000 24,145,000 22,529,000 28,677,000 24,691,000 38,566,000 52,609,000 74,880,000 79,028,000 60,843,000 78,069,000 89,631,000 70,933,000 89,925,000 107,629,000 134,782,000 91,006,000 76,947,000 88,946,000 105,676,000 79,357,000 85,917,000 101,322,000 78,036,000 77,185,000 79,598,000 82,476,000 74,252,000 43,012,000 40,450,000 56,695,000 52,824,000 54,456,000 66,785,000 72,933,000 67,173,000 64,471,000 79,640,000 56,353,000 84,815,000 90,415,000 67,549,000 70,254,000 91,478,000 56,593,000 66,903,000 70,693,000 72,577,000 74,027,000 84,461,000 87,115,000 46,260,000 58,938,000 76,598,000 101,596,000 118,850,000 
        liabilities, convertible preferred stock and stockholders’ equity
                                                                                                
        current liabilities:
                                                                                                
        accounts payable
      3,534,000 2,208,000 2,654,000 1,138,000 2,319,000 1,053,000 1,131,000 982,000 1,515,000 653,000 728,000 740,000 437,000 524,000 985,000 1,153,000 787,000 1,072,000 598,000 629,000 671,000 456,000 450,000 646,000 717,000 614,000 923,000 1,369,000 987,000 1,244,000 1,542,000 1,082,000 1,420,000 1,679,000 4,046,000 3,512,000 4,176,000 5,689,000 4,530,000 5,046,000 4,593,000 6,831,000 5,665,000 4,322,000 3,406,000 5,990,000 7,517,000 7,857,000 8,851,000 9,616,000 6,505,000 5,899,000 4,194,000 3,867,000 4,223,000 2,799,000 2,852,000 2,128,000 3,083,000 5,043,000 3,746,000  5,706,000 4,708,000 4,176,000 2,942,000 2,657,000 4,596,000 5,054,000 9,977,000 9,270,000 10,262,000 5,663,000 6,995,000 6,008,000 5,022,000 4,328,000 4,186,000 3,702,000 3,525,000 4,249,000 5,648,000 2,454,000 1,816,000 1,331,000 1,919,000 2,789,000 2,152,000 2,259,000 5,058,000 
        accrued and other current liabilities
      3,211,000 9,885,000                                                                                         
        operating lease liabilities
      2,392,000 2,464,000 2,508,000 472,000 459,000 446,000 434,000 421,000 55,000 54,000  17,000 69,000 34,000 85,000 133,000 182,000 195,000 191,000 187,000 183,000 179,000 175,000 171,000 167,000 163,000 2,353,000 2,297,000 2,242,000                                                              
        unearned revenue recognized under units-of-revenue method
      1,291,000 1,268,000 1,320,000 1,434,000 1,370,000 1,361,000 1,924,000 2,259,000 2,159,000 2,113,000 2,078,000 2,029,000 1,968,000 1,899,000 1,704,000 1,669,000 1,623,000 1,641,000 1,541,000 1,503,000 1,482,000 1,452,000 1,409,000 1,393,000 1,267,000 1,096,000 859,000 851,000 595,000 490,000 1,120,000                                                            
        preferred stock dividend accrual
      1,452,000 1,424,000 1,368,000 1,368,000 1,368,000 1,368,000 1,368,000 1,368,000 1,368,000 1,368,000 1,368,000 1,368,000 1,368,000 1,368,000 1,368,000 1,368,000 1,368,000 1,368,000 1,368,000 1,424,000 707,000                                                                      
        current portion of long-term debt
      14,013,000 12,526,000 14,345,000 11,672,000 13,697,000 11,394,000 9,826,000 5,716,000 6,144,000 5,543,000           7,201,000 8,088,000 8,962,000 7,596,000 6,390,000 5,184,000 3,981,000 2,675,000 1,729,000 789,000                                                             
        contingent value rights liabilities - current portion
      7,184,000 5,045,000 1,976,000                                                                                        
        total current liabilities
      33,077,000 34,820,000 28,305,000 21,495,000 20,434,000 24,374,000 21,134,000 18,615,000 15,540,000 19,499,000 10,334,000 7,087,000 10,094,000 6,818,000 5,425,000 8,424,000 7,890,000 12,967,000 6,508,000 6,287,000 13,105,000 12,302,000 12,335,000 11,284,000 10,123,000 8,875,000 10,089,000 11,680,000 7,149,000 5,703,000 5,619,000 3,193,000 5,880,000 7,422,000 14,224,000 21,683,000 22,245,000 32,506,000 23,014,000 24,233,000 20,450,000 23,295,000 59,137,000 29,674,000 26,427,000 36,475,000 36,376,000 37,654,000 20,253,000 29,645,000 23,989,000 21,925,000 19,107,000 23,833,000 21,784,000 18,027,000 18,857,000 21,010,000 20,419,000 19,507,000 22,333,000  17,761,000 18,157,000 19,796,000 18,678,000 25,427,000 66,022,000 75,620,000 26,992,000 28,296,000 24,634,000 16,940,000 23,600,000 21,145,000 20,198,000 17,963,000 22,667,000 16,012,000 15,459,000 14,284,000 16,544,000 11,340,000 12,058,000 14,690,000 23,603,000 18,562,000 19,532,000 28,752,000 30,458,000 
        unearned revenue recognized under units-of-revenue method – long-term
      2,860,000 3,193,000 3,473,000 3,666,000 4,084,000 4,410,000 5,589,000 5,963,000 6,692,000 7,228,000 7,796,000 8,450,000 9,044,000 9,550,000 10,381,000 10,842,000 11,346,000 11,685,000 12,306,000 12,734,000 13,130,000 13,516,000 13,952,000 14,325,000 14,842,000 15,317,000 15,876,000 16,214,000 16,807,000 17,017,000 16,522,000                                                            
        exarafenib milestone contingent consideration
      3,704,000 3,600,000 3,500,000 3,402,000 3,307,000 3,214,000 3,125,000 2,922,000                                                                                   
        long-term operating lease liabilities
      19,502,000 20,114,000 20,678,000 238,000 362,000 483,000 594,000 710,000 319,000 335,000        34,000 85,000 133,000 182,000 229,000 275,000 320,000 365,000 408,000 5,189,000 5,806,000 6,406,000                                                              
        long-term debt
      88,825,000 96,451,000 94,382,000 102,201,000 99,934,000 106,875,000 108,089,000 115,077,000 114,528,000 118,518,000           11,654,000 12,764,000 20,990,000 23,497,000 25,141,000 27,093,000 28,698,000 23,348,000 20,854,000 21,690,000 22,034,000 14,853,000 14,572,000                                                          
        contingent value rights liabilities – long-term
      10,892,000 10,457,000 4,807,000                                                                                        
        deferred tax liability
      103,000 103,000 49,000                                                                                        
        total liabilities
      158,963,000 168,738,000 155,194,000 131,002,000 128,121,000 139,356,000 138,531,000 143,287,000 137,079,000 145,580,000 18,130,000 15,537,000 19,138,000 16,368,000 15,806,000 19,266,000 19,236,000 24,686,000 18,919,000 19,174,000 38,173,000 38,861,000 47,686,000 49,461,000 50,671,000 51,736,000 60,309,000 57,342,000 51,705,000 45,000,000 45,009,000 36,364,000 37,674,000 39,149,000 45,647,000 53,260,000 53,738,000 75,887,000 55,878,000 59,011,000 60,137,000 77,189,000 108,218,000 92,129,000 91,453,000 86,532,000 89,059,000 97,497,000 105,889,000 138,769,000 104,549,000 93,809,000 89,855,000 84,209,000 99,637,000 82,054,000 81,834,000 63,025,000 55,524,000 55,460,000 58,273,000  32,965,000 33,614,000 35,362,000 35,298,000 43,680,000 85,104,000 95,825,000 98,574,000 114,162,000 110,131,000 68,554,000 84,497,000 81,164,000 81,318,000 76,177,000 129,651,000 94,490,000 94,436,000 95,977,000 93,250,000 85,017,000 86,453,000 80,573,000 70,870,000 66,110,000 67,351,000 72,211,000 70,636,000 
        commitments and contingencies
                                                                                                
        convertible preferred stock, 0.05 par value, 5,003 shares authorized, issued and outstanding as of march 31, 2026 and december 31, 2025
      20,019,000                                                                                          
        stockholders’ equity:
                                                                                                
        8.625% series a cumulative, perpetual preferred stock, 0.05 par value, 984,000 shares authorized, issued and outstanding as of march 31, 2026 and december 31, 2025
      49,000                                                                                          
        8.375% series b cumulative, perpetual preferred stock, 0.05 par value, 3,600 shares authorized, 1,760.5 issued and outstanding as of march 31, 2026 and december 31, 2025
                                                                                                
        common stock
      89,000 89,000 92,000 90,000 90,000 90,000 88,000 87,000 87,000 86,000 86,000 86,000 86,000 86,000 86,000 86,000 86,000 85,000 85,000 85,000 84,000 84,000 83,000 83,000 73,000 73,000 65,000 65,000 65,000 65,000 63,000 63,000 62,000 62,000 61,000 57,000 57,000 46,000 904,000 904,000 903,000 893,000 891,000 885,000 877,000 869,000 802,000 800,000 799,000 787,000 692,000 619,000 618,000 615,000 512,000 511,000 511,000 263,000                                 
        additional paid-in capital
      1,309,868,000 1,305,200,000 1,301,542,000 1,300,066,000 1,319,607,000 1,318,766,000 1,317,657,000 1,315,703,000 1,314,036,000 1,311,809,000 1,308,943,000 1,307,594,000 1,306,596,000 1,306,271,000 1,306,606,000 1,307,059,000 1,307,357,000 1,307,030,000 1,306,582,000 1,307,140,000 1,270,046,000 1,267,377,000 1,241,711,000 1,240,987,000 1,240,188,000 1,238,299,000 1,215,784,000 1,214,168,000 1,213,133,000 1,211,122,000 1,190,480,000 1,189,601,000 1,188,440,000 1,184,783,000 1,181,742,000 1,174,912,000 1,173,104,000 1,146,357,000 1,144,042,000 1,142,313,000 1,140,059,000 1,136,881,000 1,135,354,000 1,132,783,000 1,126,934,000 1,121,707,000 1,093,227,000 1,089,382,000 1,086,798,000 1,076,403,000 1,014,642,000 981,772,000 980,467,000 977,962,000 938,680,000 935,980,000 935,455,000 900,801,000 895,729,000 891,672,000 883,626,000  845,439,000 828,623,000 827,540,000 801,978,000 798,213,000 770,673,000 755,901,000 753,634,000 745,410,000 744,155,000 741,716,000 740,119,000 739,174,000 737,963,000 737,471,000 689,315,000 675,143,000 674,698,000 671,038,000 655,041,000 654,965,000 654,937,000 654,889,000 653,537,000 653,470,000 649,761,000 648,839,000  
        accumulated other comprehensive income
      119,000 53,000 121,000 122,000 118,000 73,000 104,000                                                                                    
        accumulated deficit
      -1,217,249,000 -1,221,450,000 -1,213,866,000 -1,227,892,000 -1,235,235,000 -1,237,057,000 -1,233,089,000 -1,215,846,000 -1,231,831,000 -1,223,223,000 -1,203,114,000 -1,197,605,000 -1,192,205,000 -1,182,392,000 -1,176,416,000 -1,172,238,000 -1,167,568,000 -1,165,288,000 -1,195,132,000 -1,190,696,000 -1,188,459,000 -1,181,086,000 -1,203,752,000 -1,202,675,000 -1,199,142,000 -1,194,384,000 -1,190,063,000 -1,193,241,000 -1,189,169,000 -1,192,402,000 -1,189,390,000 -1,184,812,000 -1,182,865,000 -1,179,059,000 -1,177,740,000 -1,204,084,000 -1,204,370,000 -1,193,613,000 -1,176,133,000 -1,163,608,000 -1,148,448,000 -1,140,083,000 -1,165,435,000 -1,164,954,000 -1,141,195,000 -1,119,477,000 -1,112,159,000 -1,097,760,000 -1,085,863,000 -1,081,176,000 -1,028,877,000 -999,253,000 -982,005,000 -957,118,000 -959,484,000 -932,633,000 -916,478,000 -886,053,000 -874,318,000 -867,776,000 -859,645,000 -853,310,000 -835,552,000 -821,919,000 -806,339,000 -784,554,000 -787,537,000 -789,075,000 -778,865,000 -785,104,000 -795,086,000 -774,724,000 -754,034,000 -739,859,000 -729,982,000 -751,799,000 -743,460,000 -727,533,000 -713,046,000 -702,210,000 -696,295,000 -675,692,000 -665,967,000 -656,973,000 -648,391,000 -678,471,000 -660,883,000 -640,740,000 -619,695,000 -599,529,000 
        total stockholders’ equity
      92,876,000 83,941,000 87,938,000 72,435,000 84,629,000 81,921,000 84,809,000 99,993,000 82,341,000 88,721,000 105,964,000 110,124,000 114,526,000 124,014,000 130,325,000 134,956,000 139,924,000 141,876,000 111,584,000 116,578,000 81,720,000 86,424,000 38,042,000 38,395,000 41,119,000 43,988,000 25,786,000 20,992,000 24,029,000 18,785,000 1,153,000 4,852,000 5,637,000 5,786,000 4,063,000           3,099,000   1,740,000     21,467,000  3,863,000 19,488,000 15,011,000                                 
        total liabilities, convertible preferred stock and stockholders’ equity
      271,858,000 272,698,000 263,151,000 223,456,000                                                                                       
        short-term royalty and commercial payment receivables under the cost recovery method
        900,000 700,000 413,000 413,000                                                                                     
        contingent consideration under rpas, aaas, and cppas
           3,000,000 4,000,000                                                                                    
        convertible preferred stock, 0.05 par value, 5,003 shares authorized, issued and outstanding as of december 31, 2025 and december 31, 2024
       20,019,000                                                                                         
        8.625% series a cumulative, perpetual preferred stock, 0.05 par value, 984,000 shares authorized, issued and outstanding as of december 31, 2025 and december 31, 2024
       49,000                                                                                         
        8.375% series b cumulative, perpetual preferred stock, 0.05 par value, 3,600 shares authorized, 1,760.5 and 1,600 shares issued and outstanding as of december 31, 2025 and december 31, 2024, respectively
                                                                                                
        accrued and other liabilities
        4,134,000 5,411,000 1,221,000 5,752,000 2,451,000 4,869,000 1,299,000 2,768,000 2,160,000 1,933,000 6,127,000 2,918,000 1,208,000 1,026,000 855,000 525,000 1,325,000 1,059,000 1,376,000 642,000 466,000 605,000 709,000 945,000 1,100,000 615,000 798,000 2,382,000 2,159,000 1,142,000 1,338,000 2,545,000 1,601,000 2,062,000 2,173,000 4,215,000 4,814,000 5,737,000 4,387,000 7,025,000 9,680,000 7,441,000 5,992,000 9,892,000 7,503,000 6,389,000 4,895,000 9,934,000 8,016,000 6,629,000 5,410,000 13,166,000 11,667,000 7,866,000 6,297,000 10,012,000 10,434,000                                
        convertible preferred stock, 0.05 par value, 5,003 shares authorized, issued and outstanding as of september 30, 2025 and december 31, 2024
        20,019,000                                                                                        
        8.625% series a cumulative, perpetual preferred stock, 0.05 par value, 984,000 shares authorized, issued and outstanding as of september 30, 2025 and december 31, 2024
        49,000                                                                                        
        8.375% series b cumulative, perpetual preferred stock, 0.05 par value, 3,600 shares authorized, 1,600 shares issued and outstanding as of september 30, 2025 and december 31, 2024
                                                                                                
        convertible preferred stock, 0.05 par value, 5,003 shares authorized, issued and outstanding as of june 30, 2025 and december 31, 2024
         20,019,000                                                                                       
        8.625% series a cumulative, perpetual preferred stock, 0.05 par value, 984,000 shares authorized, issued and outstanding as of june 30, 2025 and december 31, 2024
         49,000                                                                                       
        8.375% series b cumulative, perpetual preferred stock, 0.05 par value, 3,600 shares authorized, 1,600 shares issued and outstanding as of june 30, 2025 and december 31, 2024
                                                                                                
        liabilities and stockholders’ equity
                                                                                                
        preferred stock, 0.05 par value, 1,000,000 shares authorized:
                                                                                                
        8.625% series a cumulative, perpetual preferred stock, 984,000 shares issued and outstanding as of march 31, 2025 and december 31, 2024
          49,000                                                                                      
        8.375% series b cumulative, perpetual preferred stock, 1,600 shares issued and outstanding as of march 31, 2025 and december 31, 2024
                                                                                                
        convertible preferred stock, 5,003 shares issued and outstanding as of march 31, 2025 and december 31, 2024
                                                                                                
        total liabilities and stockholders’ equity
          212,750,000 221,277,000 223,340,000 243,280,000 219,420,000 234,301,000 124,094,000 125,661,000 133,664,000 140,382,000 146,131,000 154,222,000 159,160,000 166,562,000 130,503,000 135,752,000 119,893,000 125,285,000 85,728,000 87,856,000 91,790,000 95,724,000 86,095,000 78,334,000 75,734,000 63,785,000 46,162,000 41,216,000 43,311,000 44,935,000 49,710,000           89,631,000   107,629,000     105,676,000  85,917,000 101,322,000 78,036,000                                 
        8.625% series a cumulative, perpetual preferred stock, 984,000 shares issued and outstanding as of december 31, 2024 and december 31, 2023
           49,000                                                                                     
        8.375% series b cumulative, perpetual preferred stock, 1,600 shares issued and outstanding as of december 31, 2024 and december 31, 2023
                                                                                                
        convertible preferred stock, 5,003 shares issued and outstanding as of december 31, 2024 and december 31, 2023
                                                                                                
        short-term equity securities
            785,000 696,000 413,000 161,000 214,000 320,000 311,000 335,000 443,000 523,000 547,000 774,000 1,211,000 2,310,000                                                                       
        short-term royalty and commercial payment receivables
            12,682,000 14,257,000 9,819,000 14,215,000  4,958,000  2,366,000  2,500,000                                                                           
        long-term royalty and commercial payment receivables
            54,207,000 69,731,000 65,577,000 57,952,000 74,696,000 72,232,000 73,333,000 63,683,000 66,049,000 66,575,000 69,075,000 69,075,000                                                                         
        8.625% series a cumulative, perpetual preferred stock, 984,000 shares issued and outstanding as of september 30, 2024 and december 31, 2023
            49,000                                                                                    
        8.375% series b cumulative, perpetual preferred stock, 1,600 shares issued and outstanding as of september 30, 2024 and december 31, 2023
                                                                                                
        convertible preferred stock, 5,003 shares issued and outstanding as of september 30, 2024 and december 31, 2023
                                                                                                
        contingent consideration under rpas, aaas and cppas
             3,000,000 3,000,000 7,000,000 4,000,000 1,000,000                                                                               
        8.625% series a cumulative, perpetual preferred stock, 984,000 shares issued and outstanding as of june 30, 2024 and december 31, 2023
             49,000                                                                                   
        8.375% series b cumulative, perpetual preferred stock, 1,600 shares issued and outstanding as of june 30, 2024 and december 31, 2023
                                                                                                
        convertible preferred stock, 5,003 shares issued and outstanding as of june 30, 2024 and december 31, 2023
                                                                                                
        8.625% series a cumulative, perpetual preferred stock, 984,000 shares issued and outstanding at march 31, 2024 and december 31, 2023
              49,000                                                                                  
        8.375% series b cumulative, perpetual preferred stock, 1,600 shares issued and outstanding at march 31, 2024 and december 31, 2023
                                                                                                
        convertible preferred stock, 5,003 shares issued and outstanding at march 31, 2024 and december 31, 2023
                                                                                                
        8.625% series a cumulative, perpetual preferred stock, 984,000 shares issued and outstanding at december 31, 2023 and december 31, 2022
               49,000                                                                                 
        8.375% series b cumulative, perpetual preferred stock, 1,600 shares issued and outstanding at december 31, 2023 and december 31, 2022
                                                                                                
        convertible preferred stock, 5,003 shares issued and outstanding at december 31, 2023 and december 31, 2022
                                                                                                
        8.625% series a cumulative, perpetual preferred stock, 984,000 shares issued and outstanding at september 30, 2023 and december 31, 2022
                49,000                                                                                
        8.375% series b cumulative, perpetual preferred stock, 1,600 shares issued and outstanding at september 30, 2023 and december 31, 2022
                                                                                                
        convertible preferred stock, 5,003 shares issued and outstanding at september 30, 2023 and december 31, 2022
                                                                                                
        8.625% series a cumulative, perpetual preferred stock, 984,000 shares issued and outstanding at june 30, 2023 and december 31, 2022
                 49,000                                                                               
        8.375% series b cumulative, perpetual preferred stock, 1,600 shares issued and outstanding at june 30, 2023 and december 31, 2022
                                                                                                
        convertible preferred stock, 5,003 shares issued and outstanding at june 30, 2023 and december 31, 2022
                                                                                                
        contingent consideration under rpas and cppas
                  125,000 75,000 75,000 3,075,000 3,075,000 8,075,000                                                                         
        8.625% series a cumulative, perpetual preferred stock, 984,000 shares issued and outstanding at march 31, 2023 and december 31, 2022
                  49,000                                                                              
        8.375% series b cumulative, perpetual preferred stock, 1,600 shares issued and outstanding at march 31, 2023 and december 31, 2022
                                                                                                
        convertible preferred stock, 5,003 shares issued and outstanding at march 31, 2023 and december 31, 2022
                                                                                                
        restricted cash
                      837,000 2,049,000 3,417,000 4,840,000 2,142,000 1,611,000                                              6,061,000 13,998,000 9,545,000 13,878,000 8,285,000 903,000 6,019,000 1,640,000 5,215,000 1,619,000 4,330,000             
        income taxes payable
                       91,000               1,666,000 1,637,000 1,706,000                                                        
        8.625% series a cumulative, perpetual preferred stock, 984,000 shares issued and outstanding at december 31, 2022 and december 31, 2021
                   49,000                                                                             
        8.375% series b cumulative, perpetual preferred stock, 1,600 shares issued and outstanding at december 31, 2022 and december 31, 2021
                                                                                                
        convertible preferred stock, 5,003 shares issued and outstanding at december 31, 2022 and december 31, 2021
                                                                                                
        8.625% series a cumulative, perpetual preferred stock, 984,000 shares issued and outstanding at september 30, 2022 and december 31, 2021
                    49,000                                                                            
        8.375% series b cumulative, perpetual preferred stock, 1,600 shares issued and outstanding at september 30, 2022 and december 31, 2021
                                                                                                
        convertible preferred stock, 5,003 shares issued and outstanding at september 30, 2022 and december 31, 2021
                                                                                                
        8.625% series a cumulative, perpetual preferred stock, 984,000 shares issued and outstanding at june 30, 2022 and december 31, 2021
                     49,000                                                                           
        8.375% series b cumulative, perpetual preferred stock, 1,600 shares issued and outstanding at june 30, 2022 and december 31, 2021
                                                                                                
        convertible preferred stock, 5,003 shares issued and outstanding at june 30, 2022 and december 31, 2021
                                                                                                
        8.625% series a cumulative, perpetual preferred stock, 984,000 shares issued and outstanding at march 31, 2022 and december 31, 2021
                      49,000                                                                          
        8.375% series b cumulative, perpetual preferred stock, 1,600 shares issued and outstanding at march 31, 2022 and december 31, 2021, respectively
                                                                                                
        convertible preferred stock, 5,003 shares issued and outstanding at march 31, 2022 and december 31, 2021
                                                                                                
        cash
                       93,328,000 68,757,000 78,945,000 67,808,000 84,222,000 45,725,000 49,491,000 53,312,000 56,688,000 39,744,000 42,327,000 48,436,000                                                              
        income tax receivable
                           1,526,000 1,526,000 1,526,000 1,526,000                                                                  
        long-term equity securities
                                873,000 1,138,000 1,107,000 392,000 347,000 553,000                                                           
        contingent liabilities
                        1,410,000 1,410,000 1,410,000 1,410,000                                                                     
        other liabilities - long term
                                                549,000 556,000         33,000  1,284,000 1,181,000 1,079,000                                  
        8.625% series a cumulative, perpetual preferred stock, 984,000 shares issued and outstanding at december 31, 2021 and december 31, 2020
                       49,000                                                                         
        8.375% series b cumulative, perpetual preferred stock, 1,600 and zero shares issued and outstanding at december 31, 2021 and december 31, 2020, respectively
                                                                                                
        convertible preferred stock, 5,003 shares issued and outstanding at december 31, 2021 and december 31, 2020
                                                                                                
        long-term royalty receivables
                        55,075,000 48,075,000 48,075,000 34,575,000 34,375,000 34,375,000 34,375,000 34,375,000 34,375,000 24,375,000 15,375,000 15,000,000 15,000,000                                                            
        other assets
                        301,000 128,000 210,000 41,000 215,000 215,000 151,000 151,000 832,000 835,000 834,000 708,000 578,000 831,000 559,000 657,000 522,000 481,000 481,000 481,000 664,000 664,000 664,000 664,000 664,000 665,000 664,000 669,000 819,000 798,000 1,029,000 1,266,000 1,321,000 1,219,000 1,378,000 1,696,000 1,850,000 1,882,000 2,268,000 2,632,000 1,880,000 2,165,000 503,000  543,000 466,000 402,000 402,000 402,000 402,000 402,000 402,000 402,000 402,000 402,000 402,000                 
        contingent consideration under royalty purchase agreements
                        75,000 75,000 75,000 75,000 75,000 75,000 75,000 75,000 75,000 3,075,000                                                               
        other liabilities – long-term
                        20,000 20,000 102,000 50,000 134,000 35,000 200,000 43,000 457,000 294,000 489,000 590,000 834,000                                                            
        8.625% series a cumulative, perpetual preferred stock, 984,000 shares issued and outstanding at september 30, 2021 and december 31, 2020
                        49,000                                                                        
        8.375% series b cumulative, perpetual preferred stock, 1,600 and zero shares issued and outstanding at september 30, 2021 and december 31, 2020, respectively
                                                                                                
        convertible preferred stock, 5,003 shares issued and outstanding at september 30, 2021 and december 31, 2020
                                                                                                
        8.625% series a cumulative, perpetual preferred stock, 984,000 shares issued and outstanding at june 30, 2021 and december 31, 2020
                         49,000                                                                       
        8.375% series b cumulative, perpetual preferred stock, 1,600 and zero shares issued and outstanding at june 30, 2021 and december 31, 2020, respectively
                                                                                                
        convertible preferred stock, 5,003 shares issued and outstanding at june 30, 2021 and december 31, 2020
                                                                                                
        equity securities
                          1,021,000 1,693,000 2,572,000 531,000 408,000 681,000                                                                 
        8.625% series a cumulative, perpetual preferred stock, 984,000 shares issued and outstanding at march 31, 2021 and december 31, 2020
                          49,000                                                                      
        convertible preferred stock, 5,003 shares issued and outstanding at march 31, 2021 and december 31, 2020
                                                                                                
        8.625% series a cumulative, perpetual preferred stock, 984,000 and zero shares issued and outstanding at december 31, 2020 and december 31, 2019, respectively
                           49,000                                                                     
        convertible preferred stock, 5,003 and 6,256 shares issued and outstanding at december 31, 2020 and december 31, 2019, respectively
                                                                                                
        contract liabilities
                            798,000 798,000 798,000 798,000 798,000 798,000 798,000 798,000 798,000 798,000 798,000                                                          
        convertible preferred stock, 0.05 par value, 1,000,000 shares authorized, 5,003 and 6,256 shares issued and outstanding at september 30, 2020 and december 31, 2019, respectively
                                                                                                
        convertible preferred stock, 0.05 par value, 1,000,000 shares authorized, 5,003 and 6,256 shares issued and outstanding at june 30, 2020 and december 31, 2019, respectively
                                                                                                
        convertible preferred stock, 0.05 par value, 1,000,000 shares authorized, 6,256 shares issued and outstanding at march 31, 2020 and december 31, 2019
                                                                                                
        convertible preferred stock, 0.05 par value, 1,000,000 shares authorized, 6,256 shares issued and outstanding at december 31, 2019 and december 31, 2018
                                                                                                
        convertible preferred stock, 0.05 par value, 1,000,000 shares authorized, 6,256 shares issued and outstanding at september 30, 2019 and december 31, 2018
                                                                                                
        the accompanying notes are an integral part of these condensed consolidated financial statements.
                                                                                                
        convertible preferred stock, 0.05 par value, 1,000,000 shares authorized, 6,256 shares issued and outstanding at june 30, 2019 and december 31, 2018
                                                                                                
        convertible preferred stock, 0.05 par value, 1,000,000 shares authorized, 6,256 shares issued and outstanding at march 31, 2019 and december 31, 2018
                                                                                                
        convertible preferred stock, 0.05 par value, 1,000,000 shares authorized, 6,256 and 5,003 shares issued and outstanding at december 31, 2018 and 2017, respectively
                                                                                                
        the accompanying notes are an integral part of these consolidated financial statements.
                                                                                                
        convertible preferred stock, 0.05 par value, 1,000,000 shares authorized, 5,003 shares issued and outstanding at september 30, 2018 and december 31, 2017
                                                                                                
        unearned revenue recognized under units-of-revenue method – current
                                     171,000 658,000                                                          
        accrued interest on long-term debt – current
                                                                                                
        unearned revenue recognized under units-of-revenue method – non-current
                                     17,592,000 17,019,000                                                          
        other liabilities – non-current
                                     726,000 203,000 32,000    69,000 97,000 123,000 148,000 673,000                                                 
        convertible preferred stock, 0.05 par value, 1,000,000 shares authorized, 5,003 shares issued and outstanding at june 30, 2018 and december 31, 2017
                                                                                                
        convertible preferred stock, 0.05 par value, 1,000,000 shares authorized, 5,003 shares issued and outstanding at march 31, 2018 and december 31, 2017
                                                                                                
        accrued restructuring costs
                                       130,000 444,000 1,020,000 1,793,000 3,594,000                                                     
        deferred revenue – current
                                       1,413,000 6,287,000 1,425,000 1,381,000 899,000    3,198,000 39,345,000   1,089,000                                           1,866,000  
        interest bearing obligations – current
                                         13,539,000 12,544,000 17,855,000 12,461,000 12,138,000 10,244,000 5,910,000 4,123,000 15,793,000 15,605,000 19,247,000                      41,993,000 50,394,000                      
        accrued interest on interest bearing obligations – current
                                       18,000 140,000 125,000 178,000 254,000 310,000 288,000 327,000 331,000 324,000 332,000 335,000 257,000 237,000 299,000 264,000  1,969,000 1,694,000 1,662,000                                      
        deferred revenue – non-current
                                       17,123,000 17,101,000 17,255,000 17,408,000 18,000,000                                                     
        interest bearing obligations – non-current
                                       14,572,000 14,322,000 14,322,000 14,085,000 25,312,000 32,758,000 34,386,000 36,007,000 42,757,000                                                 
        stockholders’ equity
                                                                                                
        convertible preferred stock, 0.05 par value, 1,000,000 shares authorized, 5,003 and 0 shares issued and outstanding at december 31, 2017 and 2016, respectively
                                                                                                
        preferred stock, 0.05 par value, 1,000,000 shares authorized, 5,003 and 0 shares issued and outstanding as of september 30, 2017 and december 31, 2016, respectively
                                                                                                
        liabilities and stockholders’ deficit
                                                                                                
        stockholders’ deficit:
                                                                                                
        preferred stock, 0.05 par value, 1,000,000 shares authorized, 5,003 and 0 shares issued and outstanding as of june 30, 2017 and december 31, 2016, respectively
                                                                                                
        total stockholders’ deficit
                                         -29,115,000 -31,209,000 -47,210,000 -31,187,000 -20,445,000 -7,528,000      -18,126,000 -7,572,000                                           
        total liabilities and stockholders’ deficit
                                         24,145,000 22,529,000 28,677,000 24,691,000 38,566,000 52,609,000      70,933,000 89,925,000                                           
        preferred stock, 0.05 par value, 1,000,000 shares authorized, 5,003 and 0 shares issued and outstanding as of march 31, 2017 and december 31, 2016, respectively
                                                                                                
        marketable securities
                                             442,000 454,000 496,000                                                 
        contingent warrant liabilities
                                            9,000 269,000 3,532,000 10,464,000 4,070,000 28,956,000 31,868,000 31,828,000 33,658,000 39,379,000 47,342,000 69,869,000 39,162,000 29,618,000 27,841,000 15,001,000 32,179,000 23,293,000 21,122,000                                  
        preferred stock, 0.05 par value, 1,000,000 shares authorized, 0 issued and outstanding at december 31, 2016 and 2015
                                                                                                
        deferred revenue
                                            899,000 1,024,000 899,000      1,089,000 2,139,000 2,158,000 2,218,000 3,414,000 3,618,000 3,756,000 3,409,000 3,545,000 4,566,000 6,912,000 5,695,000 6,006,000 5,982,000 11,446,000  2,152,000 1,424,000 1,582,000 2,114,000 8,317,000 4,573,000 7,951,000 9,105,000 6,487,000 7,146,000 5,885,000 8,017,000 7,994,000 7,681,000 7,359,000 9,601,000 5,738,000 4,849,000 4,764,000 3,527,000 3,048,000 2,902,000 2,000,000 2,000,000 2,000,000 2,030,000   
        preferred stock, 0.05 par value, 1,000,000 shares authorized, 0 issued and outstanding at september 30, 2016 and december 31, 2015
                                                                                                
        preferred stock, 0.05 par value, 1,000,000 shares authorized, 0 issued and outstanding at june 30, 2016 and december 31, 2015
                                                                                                
        accumulated comprehensive loss
                                             -54,000 -42,000                             -2,000 -82,000   -9,000 -8,000  -1,000              
        preferred stock, 0.05 par value, 1,000,000 shares authorized, 0 issued and outstanding
                                                                                                
        liabilities and stockholders’ (deficit) equity
                                                                                                
        stockholders’ (deficit) equity:
                                                                                                
        total stockholders’ (deficit) equity
                                               -2,309,000 -29,190,000 -31,286,000 -13,384,000     -3,987,000 -13,543,000 -16,862,000 -909,000  -20,280,000                                    
        total liabilities and stockholders’ (deficit) equity
                                               74,880,000 79,028,000 60,843,000 78,069,000     134,782,000 91,006,000 76,947,000 88,946,000  79,357,000                                    
        deferred revenue – long-term
                                                 732,000 1,574,000 1,939,000 2,469,000 3,134,000 3,636,000 4,105,000 4,457,000 5,392,000 5,857,000 6,315,000 6,741,000 6,876,000 7,207,000 7,539,000 8,016,000 8,665,000 9,427,000  1,346,000 1,605,000 1,865,000  4,716,000 5,372,000 7,025,000  9,251,000 9,235,000 8,924,000  10,770,000 11,871,000 11,528,000  4,285,000 5,075,000 3,833,000  4,833,000 5,551,000 5,883,000  6,833,000 7,333,000 3,194,000  
        interest bearing obligations – long-term
                                                44,462,000 32,211,000 31,584,000 16,290,000 16,556,000 17,330,000 34,658,000 35,150,000 36,941,000 36,874,000 37,017,000 37,653,000 37,649,000 32,677,000 33,569,000 33,524,000 26,649,000 27,031,000       13,129,000 13,129,000 12,880,000                      
        deferred revenue - current
                                                 1,786,000 1,089,000                                              
        short-term investments
                                                    5,000,000 9,998,000 19,996,000 19,990,000   19,996,000 39,987,000 16,996,000 11,993,000              1,299,000 4,381,000 6,629,000 10,220,000 16,067,000 5,868,000 6,805,000 16,068,000 18,381,000 12,942,000 23,054,000 22,657,000 22,732,000 31,194,000   511,000 468,000 453,000 469,000 436,000 
        interest bearing obligation – current
                                                    20,030,000 20,970,000 4,085,000 5,835,000 4,085,000 4,085,000 4,085,000 3,391,000 2,349,000 2,796,000 2,796,000 2,796,000                                 
        accumulated comprehensive income
                                                    4,000 6,000 6,000 -1,000   11,000 8,000 12,000 5,000    1,000            11,000 50,000     -9,000 -44,000 -71,000 -76,000 -66,000 -32,000   280,000 197,000 183,000 198,000 166,000 
        accrued interest on interest bearing obligation – current
                                                       2,042,000                                         
        other liabilities - long-term
                                                           1,407,000    952,000                                 
        preferred stock, 0.05 par value, 1,000,000 shares authorized
                                                                                                
        warrant liability
                                                               379,000        4,760,000 5,321,000 5,550,000                       
        series b, 8,000 designated, 0 and 2,959 shares issued and outstanding at december 31, 2011 and 2010, respectively
                                                                                                
        liabilities and shareholders’ equity
                                                                                                
        warrant liabilities
                                                                896,000 1,395,000 1,854,000  1,716,000 4,836,000 7,788,000                          
        other long-term liabilities
                                                                440,000 257,000 272,000  353,000 347,000 360,000 385,000 408,000 581,000 300,000 200,000 353,000                    
        shareholders’ equity:
                                                                                                
        preference shares, 0.05 par value, 1,000,000 shares authorized
                                                                                                
        series b, 8,000 designated, 0 and 2,959 shares issued and outstanding at september 30, 2011 and december 31, 2010, respectively
                                                                                                
        common shares, 0.0075 par value, 92,666,666 shares authorized, 33,412,263 and 28,491,318 shares outstanding at september 30, 2011 and december 31, 2010, respectively
                                                                250,000                                
        total shareholders’ equity
                                                                21,661,000 24,138,000 24,203,000  10,047,000 6,836,000 21,333,000 17,526,000 10,776,000 -18,319,000 -22,892,000 -31,401,000 -49,691,000 -30,491,000 -12,201,000 318,000 9,251,000 -13,769,000 -5,923,000 -38,173,000 -37,897,000 -27,533,000 -25,284,000 -20,673,000 -10,990,000 -1,992,000 6,542,000 -24,610,000 -7,172,000 9,247,000 29,385,000 48,214,000 
        total liabilities and shareholders’ equity
                                                                77,185,000 79,598,000 82,476,000  43,012,000 40,450,000 56,695,000 52,824,000 54,456,000 66,785,000 72,933,000 67,173,000 64,471,000 79,640,000 56,353,000 84,815,000 90,415,000 67,549,000 70,254,000 91,478,000 56,593,000 66,903,000 70,693,000 72,577,000 74,027,000 84,461,000 87,115,000 46,260,000 58,938,000 76,598,000 101,596,000  
        accrued liabilities
                                                                 7,087,000 5,287,000  8,187,000 7,167,000 6,146,000 8,629,000 8,539,000 7,487,000 7,264,000 4,438,000 8,095,000 6,279,000 4,990,000 7,710,000 6,716,000 6,625,000 5,916,000 7,086,000 5,623,000 5,613,000 4,490,000 5,717,000 5,789,000 7,236,000 11,203,000 19,331,000 13,208,000 14,536,000 8,429,000 6,163,000 
        series b, 8,000 designated, 0 and 2,959 shares issued and outstanding at june 30, 2011 and december 31, 2010, respectively
                                                                                                
        common shares, 0.0075 par value, 92,666,666 shares authorized, 32,200,731 and 28,491,318 shares outstanding at june 30, 2011 and december 31, 2010, respectively
                                                                 241,000                               
        interest bearing obligation – long-term
                                                                  26,241,000    13,341,000      76,262,000 76,262,000 42,690,000  49,249,000 49,249,000 46,686,000  15,793,000 15,793,000 12,373,000  8,844,000 8,844,000   40,641,000 40,349,000   
        series a, 210,000 designated, no shares issued and outstanding at march 31, 2011 and december 31, 2010
                                                                                                
        series b, 8,000 designated, 2,959 shares issued and outstanding at march 31, 2011 and december 31, 2010
                                                                  1,000                              
        common shares, 0.0075 par value, 46,666,666 shares authorized, 29,518,896 and 28,491,318 shares outstanding at march 31, 2011 and december 31, 2010, respectively
                                                                  221,000                              
        balance sheet data
                                                                                                
        current assets
                                                                   58,880,000                             
        working capital
                                                                   23,352,000                             
        current liabilities
                                                                   35,528,000                             
        long-term liabilities
                                                                   15,133,000                             
        redeemable convertible preferences shares, at par value
                                                                   1,000                             
        total shareholders' equity
                                                                   23,591,000                             
        other current liabilities
                                                                     22,000 104,000 223,000 475,000 606,000 1,692,000 1,884,000 1,599,000                    
        interest bearing obligation - long-term
                                                                    13,505,000 13,505,000                           
        series a, 210,000 designated, no shares issued and outstanding at september 30, 2010 and december 31, 2009
                                                                                                
        series b, 8,000 designated, 2,959 shares issued and outstanding at september 30, 2010 and december 31, 2009
                                                                    1,000                            
        common shares, 0.0075 par value, 46,666,666 shares authorized, 21,195,111 and 13,536,146 shares outstanding at september 30, 2010 and december 31, 2009, respectively
                                                                    159,000                            
        series a, 210,000 designated, no shares issued and outstanding at june 30, 2010 and december 31, 2009
                                                                                                
        series b, 8,000 designated, 2,959 shares issued and outstanding at june 30, 2010 and december 31, 2009
                                                                     1,000                           
        common shares, 0.0005 par value, 400,000,000 shares authorized, 261,247,750 and 203,042,194 shares outstanding at june 30, 2010 and december 31, 2009, respectively
                                                                     131,000                           
        series a, 210,000 designated, no shares issued and outstanding at march 31, 2010 and december 31, 2009
                                                                                                
        series b, 8,000 designated, 2,959 shares issued and outstanding at march 31, 2010 and december 31, 2009
                                                                      1,000                          
        common shares, 0.0005 par value, 400,000,000 shares authorized, 261,247,750 and 203,042,194 shares outstanding at march 31, 2010 and december 31, 2009, respectively
                                                                      131,000                          
        debt issuance costs
                                                                         1,173,000 1,499,000 365,000 398,000 398,000 185,000 254,000 254,000 254,000 254,000 668,000 477,000 477,000 502,000 493,000         
        debt issuance costs—long-term
                                                                           1,224,000    722,000    2,661,000    2,683,000         
        accrued interest
                                                                       10,000 118,000 1,217,000 3,265,000 1,588,000 2,845,000 947,000 402,000 878,000 427,000 870,000 360,000 1,794,000 949,000 1,472,000 781,000 1,652,000         
        deferred revenue—long-term
                                                                       2,894,000    8,108,000    10,047,000    8,768,000    4,333,000    6,333,000     
        interest bearing obligation—long-term
                                                                       13,341,000    63,274,000    50,850,000    51,393,000    12,373,000    40,934,000     
        shareholders’ equity
                                                                                                
        series a, 210,000 designated, no shares issued and outstanding at december 31, 2009 and 2008
                                                                                                
        series b, 8,000 designated, 2,959 shares issued and outstanding at december 31, 2009 and 2008
                                                                       1,000                         
        common shares, 0.0005 par value, 400,000,000 shares authorized, 203,042,194 and 140,467,529 shares outstanding at december 31, 2009 and 2008, respectively
                                                                       101,000                         
        debt issuance costs – long-term
                                                                            1,436,000 1,537,000 482,000  786,000 849,000 913,000  2,067,000 2,187,000 2,428,000          
        series a, 210,000 designated, no shares issued and outstanding at september 30, 2009 and december 31, 2008
                                                                                                
        series b, 8,000 designated, 2,959 shares issued and outstanding at september 30, 2009 and december 31, 2008
                                                                        1,000                        
        common shares, 0.0005 par value, 400,000,000 shares authorized, 198,937,455 and 140,467,529 shares outstanding at september 30, 2009 and december 31, 2008, respectively
                                                                        99,000                        
        series a, 210,000 designated, no shares issued and outstanding at june 30, 2009 and december 31, 2008
                                                                                                
        series b, 8,000 designated, 2,959 shares issued and outstanding at june 30, 2009 and december 31, 2008
                                                                         1,000                       
        common shares, 0.0005 par value, 210,000,000 shares authorized, 164,587,434 and 140,467,529 shares outstanding at june 30, 2009 and december 31, 2008, respectively
                                                                         82,000                       
        series a, 210,000 designated, no shares issued and outstanding at march 31, 2009 and december 31, 2008
                                                                                                
        series b, 8,000 designated, 2,959 shares issued and outstanding at march 31, 2009 and december 31, 2008
                                                                          1,000                      
        common shares, 0.0005 par value, 210,000,000 shares authorized, 142,326,493 and 140,467,529 shares outstanding at march 31, 2009 and december 31, 2008, respectively
                                                                          71,000                      
        receivables
                                                                           16,686,000 7,962,000 12,529,000 7,701,000 12,135,000 13,417,000 12,257,000 9,204,000 13,390,000 6,489,000 5,602,000 6,021,000 5,186,000 4,366,000 4,374,000 1,375,000 707,000 370,000 22,000 128,000 10,625,000 
        series a, 210,000 designated, no shares issued and outstanding at december 31, 2008 and 2007
                                                                                                
        series b, 8,000 designated, 2,959 shares issued and outstanding at december 31, 2008 and 2007
                                                                           1,000                     
        common shares, 0.0005 par value, 210,000,000 shares authorized, 140,467,529 and 131,957,774 shares outstanding at december 31, 2008 and 2007, respectively
                                                                           70,000                     
        preference shares, .05 par value, 1,000,000 shares authorized
                                                                                                
        series a, 210,000 designated, no shares issued and outstanding at september 30, 2008 and december 31, 2007, respectively
                                                                                                
        series b, 8,000 designated, 2,959 shares issued and outstanding at september 30, 2008 and december 31, 2007, respectively; aggregate liquidation preference of 29.6 million
                                                                            1,000                    
        common shares, .0005 par value, 210,000,000 shares authorized, 132,429,517 and 131,957,774 shares outstanding at september 30, 2008 and december 31, 2007, respectively
                                                                            66,000                    
        prepaid expenses
                                                                             1,369,000 1,499,000 1,113,000 1,840,000 1,270,000 1,370,000 1,061,000 1,370,000 1,217,000 1,356,000 975,000 2,022,000 2,073,000 1,957,000 1,414,000     
        series a, 210,000 designated, no shares issued and outstanding at june 30, 2008 and december 31, 2007, respectively
                                                                                                
        series b, 8,000 designated, 2,959 shares issued and outstanding at june 30, 2008 and december 31, 2007, respectively; aggregate liquidation preference of 29.6 million
                                                                             1,000                   
        common shares, .0005 par value, 210,000,000 shares authorized, 132,330,012 and 131,957,774 shares outstanding at june 30, 2008 and december 31, 2007, respectively
                                                                             66,000                   
        series a, 210,000 designated, no shares issued and outstanding at march 31, 2008 and december 31, 2007, respectively
                                                                                                
        series b, 8,000 designated, 2,959 shares issued and outstanding at march 31, 2008 and december 31, 2007, respectively; aggregate liquidation preference of 29.6 million
                                                                              1,000                  
        common shares, .0005 par value, 210,000,000 shares authorized, 132,285,482 and 131,957,774 shares outstanding at march 31, 2008 and december 31, 2007, respectively
                                                                              66,000                  
        convertible debt—long-term
                                                                                   46,823,000    60,000,000         
        series a, 210,000 designated, no shares issued and outstanding at december 31, 2007 and 2006
                                                                                                
        series b, 8,000 designated, 2,959 shares issued and outstanding at december 31, 2007 and 2006; aggregate liquidation preference of 29.6 million
                                                                               1,000                 
        common shares, .0005 par value, 210,000,000 shares authorized, 131,957,774 and 105,454,389 shares outstanding at december 31, 2007 and 2006, respectively
                                                                               66,000                 
        deposits and other
                                                                                495,000 495,000 495,000      3,086,000 3,205,000 3,272,000  159,000 159,000 160,000 159,000 
        convertible debt – long-term
                                                                                    58,400,000 58,109,000 65,487,000  60,000,000 60,000,000 60,000,000      
        series a, 210,000 designated, no shares issued and outstanding
                                                                                                
        series b, 8,000 designated, 2,959 shares issued and outstanding; aggregate liquidation preference of 29.6 million
                                                                                1,000 1,000 1,000  1,000 1,000 1,000  1,000 1,000 1,000      
        common shares, .0005 par value, 210,000,000 shares authorized, 131,847,003 and 105,454,389 shares issued and outstanding at september 30, 2007 and december 31, 2006, respectively
                                                                                66,000                
        common shares, .0005 par value, 210,000,000 shares authorized, 131,730,649 and 105,454,389 shares outstanding at june 30, 2007 and december 31, 2006, respectively
                                                                                 66,000               
        common shares, .0005 par value, 210,000,000 shares authorized, 131,670,777 and 105,454,389 shares outstanding at march 31, 2007 and december 31, 2006, respectively
                                                                                  66,000              
        related party receivables
                                                                                   56,000 55,000 96,000 96,000 98,000 96,000 104,000 165,000 167,000 125,000 126,000   
        related party receivables—long-term
                                                                                   38,000    93,000    188,000    120,000 
        deposits
                                                                                   457,000 457,000 457,000 457,000 457,000    159,000     
        series a, 210,000 designated, no shares issued and outstanding at december 31, 2006 and 2005
                                                                                                
        series b, 8,000 designated, 2,959 shares issued and outstanding at december 31, 2006 and 2005; aggregate liquidation preference of 29.6 million
                                                                                   1,000             
        common shares, .0005 par value, 210,000,000 shares authorized, 105,454,389 and 86,312,712 shares outstanding at december 31, 2006 and 2005, respectively
                                                                                   53,000             
        related party receivables – long-term
                                                                                    75,000 75,000 75,000  130,000 171,000 171,000  76,000 116,000 103,000  
        series a, 135,000 designated, no shares issued and outstanding
                                                                                                
        common shares, .0005 par value, 210,000,000 shares authorized, 97,569,353 and 86,312,712 shares outstanding at september 30, 2006 and december 31, 2005, respectively
                                                                                    49,000            
        common shares, .0005 par value, 210,000,000 shares authorized, 97,409,289 and 86,312,712 shares outstanding at june 30, 2006 and december 31, 2005, respectively
                                                                                     49,000           
        long-term investments
                                                                                      1,082,000          
        common shares, .0005 par value, 210,000,000 shares authorized, 95,384,839 and 86,312,712 shares outstanding at march 31, 2006 and december 31, 2005, respectively
                                                                                      48,000          
        notes payable
                                                                                           116,000 286,000 453,000   
        capital lease obligations
                                                                                        49,000 104,000 156,000 237,000 279,000 361,000   
        series a, 135,000 designated, no shares issued and outstanding at december 31, 2005 and 2004
                                                                                                
        series b, 8,000 designated, 2,959 shares issued and outstanding at december 31, 2005 and 2004; aggregate liquidation preference of 29.6 million
                                                                                       1,000         
        common shares, .0005 par value, 210,000,000 shares authorized, 86,312,712 and 85,587,174 shares outstanding at december 31, 2005 and 2004, respectively
                                                                                       43,000         
        common shares, .0005 par value, 210,000,000 shares authorized, 86,294,010 and 85,587,174 shares outstanding at september 30, 2005 and december 31, 2004, respectively
                                                                                        43,000        
        receivables – long-term
                                                                                         218,000       
        common shares, .0005 par value, 210,000,000 shares authorized, 86,276,623 and 85,587,174 shares outstanding at june 30, 2005 and december 31, 2004, respectively
                                                                                         43,000       
        common shares, .0005 par value, 135,000,000 shares authorized, 86,252,640 and 85,587,174 shares outstanding at march 31, 2005 and december 31, 2004, respectively
                                                                                          43,000      
        convertible note
                                                                                                
        capital lease obligations—long-term
                                                                                               272,000 
        series a, 135,000 designated, no shares issued and outstanding at december 31, 2004 and 2003
                                                                                                
        series b, 8,000 designated, 2,959 shares issued and outstanding at december 31, 2004 and 2003; aggregate liquidation preference of 29.6 million
                                                                                           1,000     
        common shares, .0005 par value, 135,000,000 shares authorized, 85,587,174 and 83,998,697 shares outstanding at december 31, 2004 and 2003, respectively
                                                                                           43,000     
        prepaid expenses and other
                                                                                            1,335,000 1,146,000 1,132,000 1,267,000 
        capital lease obligations – long-term
                                                                                            74,000 137,000 148,000  
        series b, 8,000 designated, 2,959 and 2,959 shares issued and outstanding, respectively. aggregate liquidation preference of 29.6 million.
                                                                                            1,000 1,000 1,000  
        common shares, .0005 par value, 135,000,000 shares authorized, 85,565,765 and 83,998,697 shares outstanding, respectively
                                                                                            43,000    
        common shares, .0005 par value, 135,000,000 shares authorized, 84,632,381 and 83,998,697 shares outstanding, respectively
                                                                                             42,000   
        related party receivables – current
                                                                                              85,000  
        notes payable – current
                                                                                              10,389,000  
        capital lease obligations – current
                                                                                              490,000  
        convertible note – current
                                                                                              5,319,000  
        interest bearing long-term obligation
                                                                                              40,117,000 39,906,000 
        common shares, .0005 par value, 135,000,000 shares authorized, 84,313,795 and 83,998,697 shares outstanding, respectively
                                                                                              42,000  
        related party receivables—current
                                                                                               94,000 
        inventory
                                                                                                
        short-term loan
                                                                                                
        notes payable—current
                                                                                               13,343,000 
        capital lease obligations—current
                                                                                               520,000 
        deferred revenue—current
                                                                                               90,000 
        convertible note—current
                                                                                               5,284,000 
        convertible subordinated note—long-term
                                                                                                
        series a, 135,000 designated, no shares issued and outstanding at december 31, 2003 and 2002, respectively
                                                                                                
        series b, 8,000 designated, 2,959 and no shares issued and outstanding at december 31, 2003 and 2002, respectively. aggregate liquidation preference of 29.6 million at december 31, 2003
                                                                                               1,000 
        common shares, .0005 par value, 135,000,000 shares authorized, and 83,998,697 and 71,793,647 shares outstanding at december 31, 2003 and 2002, respectively
                                                                                               42,000 
        additional paid-in-capital
                                                                                               647,534,000 
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 2009-12-31 2009-09-30 2009-06-30 2009-03-31 2008-12-31 2008-09-30 2008-06-30 2008-03-31 2007-12-31 2007-09-30 2007-06-30 2007-03-31 2006-12-31 2006-09-30 2006-06-30 2006-03-31 2005-12-31 2005-09-30 2005-06-30 2005-03-31 2004-12-31 2004-09-30 2004-06-30 2004-03-31 
                                                                                                 
          cash flows from operating activities:
                                                                                                 
          net income
        4,465,000 6,103,000 14,051,000 9,191,000 2,367,000                 22,666,000   -4,758,000    3,233,000 -3,012,000    -1,319,000                               -21,785,000    6,239,000         -14,487,000 -10,836,000 -5,915,000 -20,603,000 -9,725,000 -8,994,000 -8,582,000 30,080,000     
          adjustments to reconcile net income to net cash from operating activities:
                                                                                                 
          adjustment for income from eir method purchased receivables
        4,021,000 -6,552,000 4,562,000 -5,678,000 1,743,000                                                                                     
          stock-based compensation expense
        2,281,000 3,915,000 1,770,000 1,605,000 1,983,000 2,176,000 2,590,000 2,690,000 2,856,000 2,649,000 2,717,000 2,163,000 1,570,000 988,000 805,000 837,000 978,000 1,750,000 779,000 768,000 2,898,000 692,000 708,000 773,000 1,788,000 715,000 1,494,000 1,011,000 1,728,000 869,000 847,000 770,000 1,416,000 2,408,000 2,038,000 1,855,000 1,000,000 1,445,000 1,729,000 2,165,000 2,306,000 1,409,000 1,964,000 2,689,000 3,665,000 887,000 3,537,000 2,424,000 3,924,000 1,153,000 1,227,000 1,100,000 1,619,000 916,000 2,122,000 572,000 674,000                        390,000         
          gains on acquisitions
        -3,545,000 -3,220,000                                                                                        
          gain on lease termination
        -27,000                                                                                         
          income tax expense
        1,000 54,000                                                                                        
          common stock contribution to 401
        124,000 141,000 118,000 123,000 85,000 90,000 88,000 102,000 20,000   506,000 785,000 986,000 870,000 828,000 1,134,000                                 
          amortization of intangible assets
        892,000 884,000 878,000 655,000 544,000     224,000 224,000 224,000 225,000                                                                             
          depreciation
        3,000 3,000 2,000 3,000 3,000 2,000 3,000 3,000 2,000 1,000 1,000 1,000 4,000 1,000 2,000                  58,000    185,000 203,000 215,000 213,000 417,000 444,000 458,000 458,000 457,000 464,000 477,000 561,000 601,000 633,000 780,000 816,000 889,000 1,154,000 1,265,000  1,350,000 1,356,000 1,346,000                             
          accretion of long-term debt discount and debt issuance costs
        332,000 249,000 387,000 322,000 427,000 354,000 488,000 202,000 306,000                                                                                 
          non-cash lease expense
        17,000 17,000 16,000 14,000 17,000 15,000 16,000 15,000 14,000 4,000 18,000 50,000 47,000 43,000 43,000 42,000 42,000 41,000 40,000 40,000 39,000 38,000 38,000 37,000 37,000 2,060,000 -73,000 -57,000 -40,000                                                             
          change in fair value of equity securities
        -112,000 1,140,000 3,943,000 -6,320,000 1,147,000 493,000 -89,000 -283,000 -252,000 53,000 106,000 -9,000 24,000 109,000 79,000 24,000 227,000 437,000 1,099,000 -1,289,000 672,000 879,000 -2,041,000 -123,000 273,000                                                                 
          change in fair value of available-for-sale debt securities classified as cash equivalents
        66,000 -69,000 4,000 45,000 -31,000                                                                                    
          change in fair value of derivatives
        -12,000 -103,000 15,000                                                                                       
          cvr liability working capital adjustment
        131,000                                                                                         
          changes in assets and liabilities:
                                                                                                 
          trade and other receivables
        325,000 -1,239,000 -1,209,000 3,727,000 -3,705,000 -794,000 -519,000 -523,000 1,001,000 -961,000 858,000 -895,000 -5,000 15,000 -11,000 20,000 184,000 309,000 -506,000 68,000 183,000 1,368,000 189,000 901,000 212,000 800,000 -1,207,000 178,000 -1,329,000 -111,000 -835,000 -44,000 -39,000 629,000 9,605,000 -10,098,000 33,000 219,000 203,000 1,018,000 2,092,000 35,273,000 -36,694,000 622,000 38,000 111,000 2,089,000 -1,198,000 -530,000 1,849,000 1,663,000 -1,023,000 1,997,000 -1,187,000 -600,000 3,683,000 2,168,000 2,568,000                                
          prepaid expenses and other assets
        753,000 2,000,000 124,000 539,000 1,176,000 374,000 531,000 -816,000 213,000 421,000 -105,000 -366,000 269,000 272,000 55,000 -602,000 204,000 357,000 175,000 -926,000 225,000 402,000 178,000 -644,000 147,000 505,000 103,000 -410,000 42,000 15,000 76,000              -2,000 268,000 -439,000 432,000 -923,000 1,523,000 -162,000 -78,000 -802,000 263,000 -1,127,000 2,357,000 -1,651,000 -619,000 -249,000 -1,848,000 247,000 814,000 248,000 -656,000 -207,000                         
          accounts payable and accrued liabilities
        -2,628,000 -7,349,000 -2,861,000 2,878,000 -3,265,000 2,946,000 -2,269,000 1,026,000 -105,000 31,000 215,000 -3,891,000 3,122,000 1,249,000 14,000 537,000 45,000 -190,000 207,000 -298,000 1,046,000 -78,000 -312,000 -190,000 38,000 -474,000 39,000 309,000 -116,000 617,000 643,000 -828,000 -1,593,000 -2,307,000 140,000 -907,000 -3,480,000 602,000 -1,470,000 1,831,000 -4,901,000 -1,256,000 3,589,000 2,501,000 -6,455,000 618,000 787,000 542,000 -5,721,000 5,031,000 1,998,000 3,000,000 -7,128,000 1,034,000 5,045,000 1,627,000 -3,221,000 -839,000 1,200,000 2,924,000 -5,429,000 433,000 1,923,000 1,634,000 -1,340,000                         
          operating lease liabilities
        -656,000 -608,000 -49,000 -111,000 -108,000 -99,000 -103,000 -67,000 -15,000 6,000 -18,000 -52,000 -50,000 -51,000 -48,000 -48,000 -48,000 -46,000 -45,000 -44,000 -44,000 -43,000 -41,000 -40,000 -39,000                                                                 
          unearned revenue recognized under units-of-revenue method
        -310,000 -332,000 -307,000 -354,000 -317,000 -1,742,000 -711,000 -627,000 -490,000 -533,000 -605,000 -533,000 -437,000 -636,000 -426,000 -458,000 -357,000 -521,000 -390,000 -375,000 -356,000 -392,000 -357,000 -391,000 -304,000 -322,000 -330,000 -337,000 -105,000 -135,000 -121,000 87,000 -62,000                                                         
          net cash from operating activities
        6,121,000 -5,501,000 -296,000 6,470,000 2,198,000 -2,903,000 -8,625,000 2,727,000 -4,947,000 -3,927,000 -2,099,000 -7,208,000 -4,924,000 -3,890,000 -3,663,000 -4,317,000 -1,009,000 30,642,000 -3,075,000 -3,975,000 -914,000 17,678,000 -2,436,000 -2,870,000 -2,280,000 -4,148,000 3,799,000 -3,093,000 3,157,000 -2,712,000 -2,744,000 -3,349,000 -3,839,000 -5,225,000 30,666,000 -8,407,000 -14,348,000 6,998,000 -12,045,000 -12,356,000 -16,286,000 28,767,000 -19,032,000 -16,347,000 -24,280,000 -17,379,000 -15,804,000 -16,899,000 -28,200,000 -7,313,000 -12,830,000 -11,244,000 -14,528,000 -11,333,000 -11,165,000 -6,592,000 -11,675,000 -8,087,000 -7,642,000 -10,133,000 -3,200,000 -9,627,000 -10,400,000 -16,132,000 -16,378,000 -4,021,000 10,013,000 -13,896,000 15,339,000 2,789,000 -9,342,000 -12,050,000 -14,372,000 -2,845,000 22,556,000 -6,127,000 -9,041,000 -4,694,000 -10,108,000 -4,815,000 -13,653,000 -3,095,000 -8,770,000 -13,504,000 -18,821,000 -11,766,000 -20,373,000 -9,911,000 -2,777,000 
          capital expenditures
         -3,000 -17,000  -31,000 -60,000 -181,000 -225,000 -147,000 -31,000 -49,000 -100,000 -210,000 -361,000 -498,000 -976,000 -548,000 -718,000 -888,000 -62,000 -23,000 -147,000 -107,000 -23,000 -15,000 -53,000 -179,000 -718,000 -1,930,000 -3,164,000 -2,248,000 -2,964,000 -2,673,000 -1,953,000 -1,879,000 -1,677,000 -1,558,000 -1,859,000 -3,412,000 -2,232,000 -1,151,000 -1,165,000 -296,000 -122,000 -1,084,000 -729,000 
          free cash flows
        6,121,000 -5,501,000 -296,000 6,470,000  -2,906,000 -8,625,000 2,727,000 -4,964,000 -3,927,000 -2,099,000 -7,208,000 -4,924,000 -3,890,000 -3,663,000 -4,317,000 -1,009,000 30,642,000 -3,075,000 -3,975,000 -914,000 17,678,000 -2,436,000 -2,870,000 -2,280,000 -4,148,000 3,799,000 -3,093,000 3,157,000 -2,712,000 -2,744,000 -3,349,000 -3,839,000 -5,225,000 30,666,000 -8,407,000  6,998,000 -12,045,000 -12,356,000 -16,317,000 28,767,000 -19,092,000 -16,528,000 -24,505,000 -17,379,000 -15,951,000 -16,930,000 -28,249,000 -7,413,000 -13,040,000 -11,605,000 -15,026,000 -11,333,000 -12,141,000 -6,592,000 -12,223,000 -8,805,000 -7,642,000 -10,133,000 -4,088,000 -9,689,000 -10,423,000 -16,279,000 -16,485,000 -4,044,000 9,998,000 -13,949,000 15,160,000 2,071,000 -11,272,000 -15,214,000 -16,620,000 -5,809,000 19,883,000 -8,080,000 -10,920,000 -6,371,000 -11,666,000 -6,674,000 -17,065,000 -5,327,000 -9,921,000 -14,669,000 -19,117,000 -11,888,000 -21,457,000 -9,911,000 -3,506,000 
          cash flows from investing activities:
                                                                                                 
          net cash, cash equivalents, and restricted cash acquired in generation bio acquisition
        8,458,000                                                                                         
          payment of contingent consideration related to lava cvr
        -2,141,000                                                                                         
          payments of consideration under rpas, aaas, and cppas
         -8,000,000 -16,000,000                                                                                    
          receipts under rpas, aaas, and cppas
        235,000 161,000 1,100,000 732,000 1,307,000 2,985,000                                                                                    
          net cash from investing activities
        6,552,000 19,347,000 58,213,000 -19,981,000 -6,693,000 -36,431,000 9,522,000 5,896,000 -7,246,000 5,511,000 5,494,000 -4,482,000 -7,234,000 -15,247,000 26,000 -5,000,000 -6,000,000 -7,000,000 -13,500,000 -200,000    -13,000,000 -6,000,000 -300,000    16,000 -24,000 801,000 813,000 -24,000 622,000 45,000 -31,000 4,898,000 -42,000 -181,000 -225,000 4,902,000 4,853,000 9,969,000 -49,000  -210,000 19,639,000 19,502,000  -5,522,000 -12,563,000 -548,000 -718,000 -333,000 -1,365,000 -888,000 -62,000 -23,000 -147,000 -107,000 -23,000 6,046,000 7,884,000 -3,332,000 6,771,000 -5,374,000 -6,977,000 8,769,000 -17,537,000 1,832,000 3,716,000 3,157,000 -11,402,000 8,587,000 -1,185,000 -4,443,000 5,960,000 -32,384,000 -1,165,000 206,000 -117,000 -1,084,000 -708,000 -729,000 
          cash flows from financing activities:
                                                                                                 
          principal payments – debt
        -6,391,000 -5,533,000 1,000 -5,066,000 -3,286,000 -3,616,000         -2,125,000 -2,125,000 -2,125,000 -1,313,000 -937,000 -938,000                                                                 
          debt issuance costs and loan fees paid in connection with long-term debt
        -80,000   -79,000 -80,000 -581,000                                                                                 
          payment of preferred stock dividends
        -1,424,000 -1,368,000 -1,368,000 -1,368,000 -1,368,000 -1,368,000 -1,368,000 -1,368,000 -1,368,000 -1,368,000 -1,368,000 -1,368,000 -1,368,000 -1,368,000 -1,368,000 -1,368,000 -1,368,000                                                                         
          repurchases of common stock
        -264,000 -13,648,000 -25,000 -1,825,000 -545,000 -13,000                                                                                 
          proceeds from exercise of options and other share-based compensation
        565,000 1,624,000 2,526,000 571,000 325,000 1,087,000 1,774,000 397,000 1,956,000 258,000                                                                               
          taxes paid related to net share settlement of equity awards
        -46,000 -967,000 -1,449,000 -330,000 -240,000 -785,000 -1,042,000 -53,000 -1,334,000 -143,000   -360,000 -65,000 -973,000 -9,000 -124,000 -236,000 -119,000 -2,379,000   228,000 -397,000 -48,000 -59,000 -9,000 -234,000 -3,000 -849,000                                                        
          net cash from financing activities
        -7,640,000 -10,689,000 -5,849,000 -3,031,000 -6,894,000 -1,066,000 -4,001,000 -1,104,000 -4,956,000 124,494,000 -1,368,000 -1,165,000 -1,368,000 -1,322,000 -1,260,000 -1,134,000 -735,000 -1,439,000 -1,536,000 17,810,000 -2,000,000 23,161,000 -1,321,000 -951,000 -1,096,000 21,092,000 6,618,000 2,984,000 -201,000 20,059,000 7,493,000 71,000 2,316,000 921,000 4,446,000 20,000 7,871,000 -1,846,000 -1,813,000 16,000 -3,299,000 80,000 149,000 -2,000 13,574,000 36,877,000 -732,000 -881,000 296,000 55,075,000 29,094,000 -840,000 60,000 37,862,000 3,969,000 -815,000 38,766,000 11,442,000 2,525,000 5,781,000 24,231,000 30,133,000 15,182,000 -37,000 20,993,000 227,000 -15,949,000 12,067,000 41,000 -6,233,000   -8,082,000 1,112,000 208,000 2,072,000 -4,605,000 33,581,000 240,000 3,083,000 12,007,000 3,355,000 -31,000 8,759,000 56,486,000 -239,000 3,398,000 -13,930,000 -2,768,000 
          net increase in cash, cash equivalents, and restricted cash
        5,033,000 3,157,000                                                                                        
          cash, cash equivalents, and restricted cash as of the beginning of the period
        133,710,000 106,416,000                                                                                    
          cash, cash equivalents, and restricted cash as of the end of the period
        138,743,000 3,157,000 52,068,000 -16,542,000 95,027,000 -40,400,000                                                                                    
          supplemental cash flow information:
                                                                                                 
          cash paid for interest
        5,555,000   6,078,000 6,205,000 3,780,000         191,000 120,000 146,000 167,000 180,000 199,000 201,000 140,000 110,000 107,000      122,000 396,000 418,000 597,000 481,000 646,000 475,000                                                
          cash paid for taxes
           277,000         -19,000 95,000                                                                        
          non-cash investing and financing activities:
                                                                                                 
          accrual of contingent value rights liability in the generation bio acquisition
        4,583,000                                                                                         
          transaction costs in connection with generation bio acquisition included in accounts payable and accrued expenses
        35,000                                                                                         
          adjustment to the contingent value rights liability soon after the acquisitions
        229,000                                                                                         
          reclassification of liability awards to equity classified
        3,509,000                                                                                         
          preferred stock dividend accrual
        1,452,000   1,368,000 1,368,000 1,368,000 1,368,000 -56,000 717,000 707,000                                                                     
          credit losses on purchased receivables
                                                                                                 
          gain on sale of equity securities
                                                                                                
          net cash acquired in kinnate acquisition
                                                                                               
          net cash acquired in turnstone acquisition
                                                                                                 
          net cash and restricted cash acquired in hillevax acquisition
                                                                                                 
          net cash, cash equivalents, and restricted cash acquired in lava acquisition
                                                                                                 
          net cash and cash equivalents acquired in mural acquisition
                                                                                                 
          net payment for ip acquired under the pulmokine acquisition
                                                                                                 
          payment for bioinvent contract-based intangible asset
         -111,000                                                                                       
          payment of contingent consideration related to kinnate ip asset
                                                                                                
          purchase of property and equipment
             -3,000 -17,000                                             -548,000 -718,000   -888,000 -62,000 -23,000 -147,000 -107,000 -23,000 -15,000 -53,000 -179,000 -718,000 -1,930,000 -3,164,000 -2,248,000 -2,964,000 -2,673,000 -1,953,000 -1,879,000 -1,677,000 -1,558,000 -1,859,000 -3,412,000 -2,232,000 -1,151,000 -1,165,000 -296,000 -122,000 -1,084,000   
          purchase of equity securities
                                                                                               
          sale of equity securities
                                                                                                
          payment to issue short-term loan to xeno
                                                                                                 
          receipt from short-term loan repayment by xeno
                                                                                                 
          proceeds from issuance of common stock
                                                                                                 
          proceeds from issuance of preferred stock
                                                                                               
          payments of preferred and common stock issuance and financing costs
                                                                                                 
          net cash, cash equivalents, and restricted cash acquired in turnstone acquisition
                                                                                                 
          net cash, cash equivalents, and restricted cash acquired in hillevax acquisition
                                                                                                 
          gain on the acquisition of kinnate
                                                                                               
          net decrease in cash, cash equivalents, and restricted cash
           -16,542,000 -11,389,000                                                                                     
          estimated fair value of the exarafenib milestone asset
                                                                                                 
          estimated fair value of the exarafenib milestone contingent consideration
                                                                                                 
          right-of-use assets obtained in exchange for operating lease liabilities in kinnate acquisition
                                                                                               
          relative fair value basis reduction of rights-of-use assets in kinnate acquisition
                                                                                                 
          accrual of contingent consideration under the affitech cppa
             3,000,000 3,000,000                                                                                
          excise tax accrual due to stock repurchases
                                                                                                 
          transaction costs in connection with bioinvent ip acquisition included in accounts payable
                                                                                                 
          adjustments to reconcile net income to net cash from (used in) operating activities:
                                                                                                 
          net loss
             -3,968,000   -8,595,000 -20,109,000 -5,509,000 -5,400,000 -9,813,000  -4,178,000 -4,670,000 -2,280,000  -4,436,000 -2,237,000 -7,373,000           -1,947,000 -3,806,000   286,000 -10,715,000 -17,480,000 -12,525,000 -15,160,000 -8,365,000 25,352,000 -481,000 -23,759,000 -21,718,000 -7,318,000 -14,399,000 -11,897,000 -4,687,000 -52,299,000 -29,624,000 -17,248,000 -24,887,000 2,366,000 -26,851,000 -16,155,000 -30,425,000  -6,542,000 -8,131,000 -6,335,000  -13,633,000    1,538,000   9,982,000 -20,362,000 -20,690,000 -14,175,000  21,817,000 -8,338,000 -15,928,000         -17,588,000 -20,143,000 -21,043,000 -20,168,000 
          adjustments to reconcile net loss to net cash from operating activities:
                                                                                                 
          income from purchased receivables under the eir method
                                                                                                 
          impairment charges
                                                                                                 
          income tax benefit
                                                                                                 
          change in fair value of contingent consideration under rpas, aaas, and cppas
                                                                                               
          ​
                                                                                                 
          proceeds from issuance of long-term debt
                                 6,500,000                               20,102,000               33,538,000           
          right-of-use assets obtained in exchange for operating lease liabilities
                 383,000 85,000                                                                             
          issuance of common stock warrants in connection with long-term debt
                                                                                                 
          accrued issuance costs in connection with issuance of long-term debt
                                                                                                 
          estimated initial fair value of contingent consideration under the ladrx agreement
                                                                                                 
          estimated initial fair value of the exarafenib milestone asset in kinnate acquisition
                                                                                                
          estimated initial fair value of the exarafenib milestone contingent consideration in kinnate acquisition
             -5,844,000                                                                                    
          relative fair value basis reduction of right-of-use assets in kinnate acquisition
                                                                                               
          accrual of contingent consideration under the ladrx aaa
                                                                                                
          income from purchased receivables under effective interest rate method
              -5,423,000                                                                                   
          royalty purchase agreement asset impairment
              14,000,000                                                                                  
          estimated fair value of contingent consideration under the ladrx agreements
                                                                                               
          payments of consideration under rpas, aaas and cppas
               -22,000,000 -15,000,000                                                                               
          receipts under rpas, aaas and cppas
               8,970,000 7,771,000 5,528,000 5,494,000                                                                               
          net decrease in cash, cash equivalents and restricted cash
               7,519,000 -17,149,000  2,027,000 -12,855,000 -13,526,000  -4,897,000                                                                           
          cash, cash equivalents and restricted cash as of the beginning of the period
                                                                                                 
          cash, cash equivalents and restricted cash as of the end of the period
                                                                                                 
          cash, cash equivalents and restricted cash at the beginning of the period
                159,550,000  57,826,000                                                                             
          cash, cash equivalents and restricted cash at the end of the period
                142,401,000 126,078,000 2,027,000 -12,855,000 44,300,000 -20,459,000 -4,897,000 -5,451,000 88,633,000                                                                         
          accretion of long-term debt
                                                                                                 
          income taxes payable
                     -91,000                 -69,000                                                        
          payment for ip acquired under the obseva ip acquisition agreement
                                                                                                 
          debt issuance costs and loan fees
                                     -36,000           -35,000 -477,000                                             
          net increase in cash, cash equivalents and restricted cash
                                                                                                 
          cash, cash equivalents at the beginning of the period
                                                                                                 
          accrued transaction costs in connection with obseva ip acquisition
                                                                                                 
          payments of consideration under rpas and cppas
                    -9,600,000                                                                             
          receipts under rpas and cppas
                    2,366,000                                                                             
          estimated fair value of contingent consideration under the aptevo cppa
                    50,000                                                                             
          amortization of debt issuance costs, debt discount and final payment on debt
                         73,000 127,000 152,000 172,000 183,000 191,000 202,000 156,000 124,000 110,000 105,000 24,000                                                           
          loss on extinguishment of debt
                                       135,000 515,000                                                     
          reduction of contingent nih refund liability
                                                                                                 
          income tax receivable
                         1,526,000 -1,526,000                                                                 
          contingent nih refund liability
                                                                                                 
          other liabilities
                         -21,000 -57,000 51,000 88,000 100,000 151,000 158,000 167,000 167,000 186,000 241,000 399,000 437,000 324,000 18,000      -500,000 -49,000 -7,000   -2,000 -5,000 -30,000 -51,000 -5,000 -4,000 -108,000 -1,554,000 122,000 15,000 -25,000 -37,000 -119,000 103,000 65,000 -90,000 9,000 -17,000 -95,000 -144,000 -275,000 -304,000 -805,000 -92,000 132,000                    
          payment of preferred and common stock issuance costs
                         -137,000 -142,000        -1,000 -376,000                                                             
          payment for extinguishment of debt
                                                                                               
          payment for debt modification fee
                                                                                                
          cash and restricted cash at the beginning of the period
                     95,377,000 86,364,000                                                                     
          estimated fair value of contingent consideration under the affitech cppa
                                                                                                 
          payment of contingent consideration under rpas and cppas
                      -3,000,000 -5,000,000                                                                         
          receipts related to purchase of royalty rights and other commercial payment rights
                                                                                                 
          payments related to purchase of royalty rights and other commercial payment rights
                                                                                                 
          proceeds from exercise of options
                      468,000 299,000 1,606,000  137,000 847,000 508,000  17,000   -166,000 519,000 20,000 237,000 70,000 32,000 467,000 14,000                                                         
          accrued cost related to issuance of preferred stock
                                                                                                 
          net decrease in cash and cash equivalents
                        -6,744,000               -3,278,000 -1,503,000   -7,580,000 -5,697,000 5,124,000 -13,236,000 -12,299,000 -19,614,000  -18,911,000 -16,534,000 -10,954,000                           11,919,000 -13,685,000   -339,000 -10,489,000          -18,059,000 -24,549,000 -6,274,000 
          accrued cost related to issuance of common stock
                                                                                                 
          non-cash portion of novartis milestone payment
                                                                                                 
          receipts related to purchased royalty rights
                                                                                                 
          payment for preferred stock dividends
                         -1,368,000 -1,424,000                                                                       
          other
                                      1,000 -21,000 -201,000 205,000 2,000 55,000 33,000 33,000 48,000 -2,000                                                 
          net increase in cash and restricted cash
                                                                                                 
          cash and restricted cash at the end of the period
                         23,203,000 -11,611,000 13,835,000 69,950,000                                                                     
          interest added to principal balance on long-term debt
                             173,000   334,000                                                            
          accrued cost related to issuance of capital stock
                                                                                                 
          depreciation and amortization
                          2,000 2,000 2,000 3,000 7,000 6,000 6,000 6,000 7,000 6,000 6,000 7,000 8,000 7,000 8,000    147,000                         1,372,000 1,393,000 1,445,000 1,511,000 1,547,000 1,686,000 1,782,000 1,816,000 1,796,000 1,717,000 1,595,000 1,613,000 1,574,000 1,558,000 1,541,000 1,482,000 1,386,000 1,348,000 1,223,000 1,160,000 1,724,000 1,141,000 1,113,000 1,105,000 1,293,000 1,076,000 1,101,000 1,083,000 
          provision for bad debt
                              1,409,000                                                                 
          payments related to purchase of royalty rights
                          -7,000,000 -13,500,000     -13,000,000                                                               
          principal payments – finance lease
                             -3,000 -5,000   -4,000 -4,000 -4,000 -3,000                                                             
          proceeds from disgorgement of stockholder's short-swing profits
                             13,000                                                                 
          net decrease in cash and restricted cash
                          -11,611,000 13,835,000 -16,414,000                                                                     
          payment of preferred and common stock issuance costs for current and prior year
                            -264,000                                                                     
          accrued financing costs related to issuance of common stock
                            87,000                                                                     
          accrued financing costs related to issuance of preferred stock
                            81,000                                                                     
          payments in excess of loss recognized upon early lease termination
                                                                                                 
          accrued cost related to issuance of preferred and common stock
                                                                                                 
          issuance of common stock warrant under svb loan
                                 66,000                                                            
          estimated fair value of contingent consideration under the royalty purchase agreements
                                 -3,000,000                                                               
          proceeds from issuance of common stock, net of issuance costs
                                21,912,000   3,732,000 22,000 2,309,000     12,000   121,000 149,000 77,000 134,000 37,919,000 310,000 160,000 3,053,000 54,379,000 29,697,000 202,000 60,000 37,867,000 198,000 -54,000 39,480,000                                 
          payment of stock issuance costs
                              -20,000                                                                   
          net decrease in cash
                              -3,766,000    -2,583,000                                                               
          cash at the beginning of the period
                              56,688,000 45,780,000                                                             
          cash at the end of the period
                              -3,766,000 -3,821,000 53,312,000 16,944,000 -2,583,000 -6,109,000 48,436,000                                                             
          accrued cost related to issuance of stock
                                                                                                 
          payment of preferred and common stock issuance costs for prior year
                                -166,000                                                                 
          net increase in cash
                                -3,376,000    2,656,000                                                             
          prepaid financing cost related to issuance of common stock
                                      100,000                                                         
          fair value of rezolute common stock shares received as consideration for license agreement
                                                                                               
          realized gain on foreign currency exchange
                                                                                                 
          income tax payable
                                     -1,666,000 29,000                                                         
          proceeds from issuance of convertible preferred stock, net of issuance costs
                                                                                                 
          effect of exchange rate changes on cash
                                     20,000 12,000 194,000 6,000 -33,000  -4,000 2,000 -24,000 14,000 -4,000 -23,000 -15,000            -573,000                             
          loss on sublease
                                      830,000                                                           
          change in fair value of long-term equity securities
                                  265,000 -31,000 -715,000 -45,000 206,000                                                           
          the accompanying notes are an integral part of these condensed consolidated financial statements.
                                                                                                 
          purchase of royalty rights in connection with bioasis purchase agreement
                                    -300,000                                                             
          estimated fair value of contingent consideration under the bioasis royalty purchase agreement
                                    75,000                                                             
          license fee recognized related to repayment of principal and accrued interest under the servicer loan
                                                                                                 
          realized loss on foreign currency exchange
                                                                                                 
          net gain on sale, disposal and impairment of equipment
                                                                                                 
          proceeds from sale of equipment
                                           801,000 813,000                                                     
          purchase of royalty rights in connection with agenus purchase agreement
                                                                                                
          payment of final fee related to loan extinguishment
                                         -1,150,000                                                     
          principal payments – capital lease
                                     -3,000 -3,000 -3,000 -4,000                                                         
          net increase in cash and cash equivalents
                                     17,347,000    -4,276,000            24,385,000 -11,835,000 -7,811,000 -27,953,000 27,671,000 16,054,000 7,555,000 5,034,000 3,146,000 -12,718,000 -19,970,000 26,543,000 2,064,000 -5,450,000 -5,717,000 20,143,000 20,444,000 4,759,000 -16,316,000 4,508,000 -3,817,000 110,000 6,055,000 12,048,000 3,327,000    -19,270,000      -2,917,000 -6,089,000   -5,910,000 37,871,000     
          cash and cash equivalents at the beginning of the period
                                     43,471,000  25,742,000  65,767,000  78,445,000  101,659,000  45,345,000  48,344,000 37,304,000 23,909,000 9,513,000 22,500,000 28,002,000 20,804,000 23,808,000 84,812,000 
          cash and cash equivalents at the end of the period
                                     17,347,000 -10,257,000 -3,278,000 41,968,000  35,282,000 -7,580,000 20,045,000  -13,236,000 -12,299,000 46,153,000  -18,911,000 -16,534,000 67,491,000  -11,835,000 -7,811,000 73,706,000  16,054,000 7,555,000 50,379,000  -12,718,000 -19,970,000 74,887,000 2,637,000 -5,450,000 -5,717,000 56,874,000 20,444,000 4,759,000 -16,316,000 28,417,000 -3,817,000 110,000 6,055,000 21,561,000 3,327,000 -14,548,000 11,919,000 8,815,000 -19,270,000 24,596,000 -339,000 17,513,000 17,485,000 -1,281,000 -2,917,000 14,715,000 6,220,000 -41,185,000 -5,910,000 61,679,000 -12,122,000 -18,059,000 -24,549,000 78,538,000 
          the accompanying notes are an integral part of these consolidated financial statements.
                                                                                                 
          unrealized loss on foreign currency exchange
                                          248,000 938,000 261,000  135,000 -310,000 559,000            -440,000 383,000 295,000 -759,000 376,000 -623,000 -740,000 257,000 1,619,000                             
          gain on sale and disposal of equipment
                                                                                                 
          repayment of principal and accrued interest under the servier loan
                                                                                                 
          accrued interest on long-term debt
                                       143,000 138,000                                                         
          gain on sale of equipment
                                            -1,314,000                                                     
          prepaid expenses and other current assets
                                        53,000   -70,000 345,000 358,000 -205,000 466,000 415,000 991,000 -761,000                        327,000 -680,000 318,000 562,000                    
          proceeds from sale of property and equipment
                                            4,000              11,000                                    
          other receivable related to sale of equipment
                                                                                                 
          license fee recognized related to repayment of principal and accrued interest under the servier loan
                                                                                                 
          unrealized gain on foreign currency exchange
                                                  227,000 378,000 -1,949,000  -1,300,000 -175,000 -66,000  173,000                                       
          revaluation of contingent warrant liabilities
                                             -9,000 -260,000 -3,263,000 -6,932,000 6,394,000 -24,422,000 176,000 40,000 -12,088,000 -5,721,000 -7,962,000 -20,002,000 35,294,000 11,124,000 1,781,000 12,840,000 -16,574,000 9,208,000 2,181,000 14,357,000                                 
          gain on sale of marketable securities
                                                                                                
          impairment of non-marketable cost method investment
                                                                                                 
          gain on sale of business in connection with agenus asset purchase agreement
                                                                                                 
          accrued restructuring costs
                                         -314,000 -576,000 -773,000 -1,801,000                                                     
          accrued interest on interest bearing obligations
                                         129,000 41,000 178,000 -76,000 156,000 22,000 159,000 -6,000 199,000 -29,000 120,000 90,000 184,000 -58,000 194,000 -1,764,000 253,000 274,000 215,000 1,542,000 308,000 267,000 217,000 394,000 261,000 267,000 264,000 231,000  96,000 83,000 81,000  -1,099,000 -1,799,000 1,677,000                     
          deferred revenue
                                         9,494,000 -9,638,000 -109,000 -110,000 18,000,000 -125,000 125,000 -2,306,000 -36,112,000 36,810,000 -179,000 -163,000 -449,000 -1,515,000 -495,000 -524,000 -1,963,000 -723,000 -602,000 -111,000 -563,000 -1,155,000 -2,677,000 884,000 -786,000 -626,000 -6,226,000 -6,156,000 14,632,000 469,000 -418,000 -1,561,000 -8,025,000 3,088,000 -5,031,000 -2,237,000 1,475,000 -643,000 1,572,000 -3,255,000 -700,000 613,000 665,000 518,000 8,346,000 99,000 1,327,000 737,000 -21,000 -572,000 570,000 -450,000 -500,000 -530,000 4,303,000 4,970,000 
          purchases of property and equipment
                                                                                                 
          proceeds from sale of marketable securities
                                                                                                
          proceeds from sale of business in connection with agenus asset purchase agreement
                                                                                                 
          proceeds from exercise of warrants
                                                   35,000 1,738,000                                        
          proceeds from issuance of long term debt
                                                 20,000,000                                             
          cash and cash equivalents at the beginning of the year
                                                                                                 
          cash and cash equivalents at the end of the year
                                                                                                 
          common stock contribution to 401(k) plan
                                                                                                 
          amortization of debt issuance costs, debt discount and final payment fee on debt
                                          39,000 119,000 286,000 376,000 359,000                                                   
          net gain on sale and disposal of equipment
                                                                                                 
          proceeds from issuance of common and preferred stock, net of issuance costs
                                          4,487,000 20,000 25,452,000                                                     
          principal payments ─ debt
                                          -16,380,000  -1,786,000 -3,271,000                                                 
          principal payments ─ capital lease
                                          -51,000  -27,000 -29,000 -28,000                                                 
          other receivables related to the sale of equipment
                                            811,000                                                     
          loss on loan extinguishment
                                                 429,000                                             
          impairment of long-lived assets and non-marketable cost method investment
                                                                                                 
          accrued restructuring
                                                                                                 
          proceeds from maturities of investments
                                                     5,000,000 5,000,000   20,000,000 20,000,000             1,300,000 2,630,000 2,675,000                   
          effect of exchange rate on cash
                                                                                                 
          marketable securities received in conjunction with the disposal of business
                                                                                                 
          equipment acquired through capital lease
                                                                                                 
          reclassification of contingent warrant liability to equity upon exercise of warrants
                                                 -464,000   -1,000 -2,525,000 -4,586,000                                        
          issuance of warrants
                                                    450,000                                             
          interest added to principal balances on long-term debt
                                                 168,000   156,000   190,000 272,000 183,000 290,000 219,000 343,000 200,000 398,000                                 
          non-cash financing activities:
                                                                                                 
          issuance of common stock warrants in connection with hercules term loan
                                                                                                
          amortization of debt discount, final payment fee on debt, and debt issuance costs
                                                354,000 383,000 374,000 360,000 296,000 666,000 679,000 688,000 674,000 629,000 627,000 611,000 603,000 570,000 449,000                                   
          net purchase of property and equipment
                                                -31,000  -60,000 -181,000 -225,000  -147,000 -31,000 -49,000 -100,000 -210,000 -361,000 -498,000  -976,000                                   
          loss on sale and retirement of property and equipment
                                                                                                 
          unrealized loss on foreign exchange options
                                                 1,000 -1,000 1,000 5,000 29,000 87,000 117,000 122,000 -57,000 -5,000 189,000 -7,000 110,000 335,000 276,000                                 
          other non-cash adjustments
                                                     -4,000 -3,000 -3,000 1,000 1,000 1,000 -18,000 -4,000 1,000 8,000 52,000 -43,000 60,000 36,000 1,000 10,000 -9,000 7,000 11,000 1,000     -3,000 6,000 -20,000 -3,000 -520,000 514,000 -1,000 1,000 -2,000 -2,000         
          purchase of investments
                                                                             -3,199,000 -15,069,000 -5,275,000 -5,750,000 -6,900,000 -8,500,000 -3,800,000 -6,700,000 -9,391,000         
          investment in symplmed pharmaceuticals, llc
                                                                                                 
          gain on sale and retirement of property and equipment
                                                                                                 
          principal payments of debt
                                                  -45,000 -6,083,000 -1,042,000 -1,042,000 -1,041,000 -2,792,000 -1,042,000 -1,041,000   -715,000 -714,000 -714,000                                
          cash paid for:
                                                                                                 
          interest
                                                   459,000 333,000 161,000 435,000 219,000 2,194,000 274,000 309,000 346,000 333,000 312,000 257,000                                   
          restructuring charge related to long-lived assets
                                                             219,000 160,000 374,000 1,707,000                                 
          proceeds from issuance of long-term debt, net of issuance costs
                                                             -5,000                                    
          cash paid during the year for:
                                                                                                 
          discount on long-term debt
                                                                -215,000 -8,899,000                             
          loss on sale costs and retirement of property and equipment
                                                                                                 
          investment in noncontrolling interest
                                                                                                 
          loss on sale and retirement of property & equipment
                                                                                                
          net from investing activities
                                                                                                 
          income taxes
                                                                    15,000                             
          loss on sale costs and retirement of property & equipment
                                                                                                 
          payment of issuance costs on long-term debt
                                                                                                 
          warrant modification expense
                                                                     4,500,000                         
          net used in investing activities
                                                                                                 
          payment for modification of warrants
                                                                     -4,500,000                         
          issuance of contingent warrant liabilities, net of extinguishments
                                                                                                 
          purchases of investments
                                                              -4,998,000                                   
          issuance of contingent warrant liabilities
                                                              -323,000 -10,000 6,386,000                                 
          amortization of discount and final payment fee on debt and debt issuance costs
                                                                467,000                                 
          cash paid during the quarter for:
                                                                                                 
          revaluation of warrant liability
                                                                     2,528,000 -3,120,000   -561,000 -229,000                       
          amortization of discount on debt and debt issuance costs
                                                                                                 
          loss on debt extinguishment
                                                                                                 
          transfer of restricted cash
                                                                         6,061,000 7,937,000 -4,453,000 4,333,000 -5,593,000 -7,382,000 5,116,000 -4,379,000 3,575,000 -3,596,000 2,711,000             
          payment of prepayment premium on repayment of short-term debt
                                                                                                 
          issuance and extinguishment of warrants
                                                                                                 
          common shares contribution to 401
                                                                                                
          share-based compensation expense
                                                                  1,542,000 2,284,000 1,772,000 1,170,000 1,662,000 1,120,000 961,000 997,000 1,513,000 856,000 1,029,000 966,000 1,087,000 2,370,000 511,000 723,000 1,002,000 371,000 762,000 147,000 184,000           
          revaluation of warrant liabilities
                                                                  -499,000 -460,000 -2,390,000    1,261,000                         
          amortization of discount on long-term debt
                                                                  358,000 363,000 298,000                             
          unrealized gain on foreign exchange options
                                                                  -1,000                               
          changes in assets and liabilities affecting cash:
                                                                                                 
          proceeds from issuance of common shares
                                                                  2,525,000 5,781,000 4,129,000 30,133,000 15,182,000 -37,000 25,493,000 2,770,000 26,044,000 20,468,000 41,000 7,262,000 168,000 70,000 78,000 223,000 208,000 121,000 102,000 43,000 240,000 78,000 40,000 27,000 28,000 35,000 61,000 47,000 3,710,000 922,000 399,000 
          cash paid for income taxes
                                                                                                
          issuance and extinguishment of warrant liabilities
                                                                     1,767,000                         
          interest added to principal balance on novartis note
                                                                    189,000                           
          interest added to principal balance on servier loan
                                                                                                 
          receivables
                                                                   -826,000 10,631,000 -12,920,000 572,000 -724,000 -561,000 -4,028,000 3,080,000 3,006,000 7,397,000 -8,724,000 4,567,000 -4,828,000 4,434,000 1,320,000                
          common shares contribution to 401(k) and management incentive plans
                                                                    1,046,000 905,000 1,198,000 1,008,000       1,088,000 49,000 13,000 1,291,000 20,000 906,000 
          accrued interest on convertible notes and interest bearing obligations
                                                                                                 
          amortization of discount, premium and debt issuance costs of debt and convertible debt
                                                                                                 
          loss on disposal/retirement of property and equipment
                                                                         127,000   49,000 -42,000 92,000 132,000 14,000 1,000 6,000 4,000     -2,000    
          proceeds from sales of investments
                                                                                               
          debt reduction on novartis note
                                                                                                 
          amortization of discount, premium and debt issuance costs of interest bearing obligations
                                                                          1,173,000 326,000 90,000                     
          suppemental cash flow information:
                                                                                                 
          cash paid during the nine months ended september 30, 2010 for:
                                                                                                 
          income taxes, including foreign withholding taxes
                                                                                                
          cash paid during the first half of 2010 for:
                                                                                                 
          revaluation of embedded derivative
                                                                                 6,101,000 2,801,000 176,000 -4,050,000 8,018,000         
          interest paid on conversion of convertible debt
                                                                                 -5,172,000             
          fair value of warrant liability
                                                                                                 
          conversion of convertible debt to equity
                                                                                                 
          amortization of premiums on short-term investments
                                                                          1,000 10,000 2,000 8,000                 
          impairment charge of property and equipment
                                                                                                
          accounts payable
                                                                          -1,939,000 -458,000 -4,923,000 707,000 -992,000 4,599,000 -1,332,000 986,000 986,000 695,000 142,000 484,000 177,000 -724,000 -1,399,000 3,194,000 638,000 485,000 -588,000 -870,000 637,000 -108,000 -2,798,000 
          accrued liabilities
                                                                          1,052,000 223,000 2,826,000 -3,657,000 1,816,000 1,289,000 -2,720,000 994,000 92,000 709,000 -1,171,000 1,463,000 10,000 1,123,000 -1,227,000 717,000 -673,000 -4,956,000 -8,702,000 6,123,000 -1,328,000 6,105,000 2,268,000 
          transfer of maturities to short-term investments
                                                                                                 
          principal payments of long-term debt
                                                                             -13,495,000 -24,124,000 -8,160,000    -4,707,000             
          principal payments of short-term debt
                                                                                                 
          accrued interest on convertible notes and other interest bearing obligations
                                                                             -751,000 1,898,000 1,250,000 -476,000 1,162,000 -443,000 1,122,000 -1,433,000 1,446,000 -524,000 1,108,000 -871,000 863,000 -774,000 989,000 574,000 293,000 291,000 -311,000 305,000 
          amortization of discount, premium and debt issuance costs of long-term and convertible debt
                                                                                                 
          other assets
                                                                                                 
          proceeds from issuance of convertible notes
                                                                                     2,000 11,967,000    56,621,000     
          amortization of discount, premium and debt issuance costs of convertible debt and interest bearing obligations
                                                                              101,000 723,000 309,000                 
          prepaid expenses
                                                                               130,000 -386,000 727,000 -569,000 99,000 -309,000 309,000 -153,000 139,000 -381,000 554,000 52,000 -106,000 -60,000     
          net cash provided (used) by financing activities
                                                                                                 
          proceeds from sales/maturities of investments
                                                                                9,100,000 4,875,000 6,205,000 15,015,000 9,225,000 3,105,000 13,945,000           
          amortization of discount, premium and debt issuance costs of convertible debt
                                                                                                 
          gain on extinguishment of debt
                                                                                                 
          loss on sale of investments
                                                                                                 
          principal payments of short-term loan
                                                                                         -115,000 -170,000 -167,000   
          payments under capital lease obligations
                                                                                         -49,000 -55,000 -52,000 -81,000 -116,000 -145,000 -141,000 -153,000 
          common shares contributed to 401(k) and management incentive plans
                                                                                  1,321,000             
          proceeds from issuance (principal payments of) long-term debt
                                                                                                
          amortization of discount, premium and issuance costs of convertible debt
                                                                                   63,000 394,000  257,000 261,000 232,000         
          amortization of premium on short-term investments
                                                                                   -1,000 -3,000  -6,000 19,000 16,000         
          receivables and related party receivables
                                                                                   -3,053,000 4,242,000 -6,865,000 -846,000 419,000 -815,000 -785,000 275,000 -3,156,000 -649,000 -491,000 -307,000 54,000 10,521,000 
          deposits
                                                                                                 
          proceeds from short-term loan
                                                                                               
          principal payments of convertible notes
                                                                                               
          gain on sale of investments
                                                                                          -15,000 -271,000     
          proceeds from sale of investments
                                                                                        8,360,000         
          increase in notes to a collaborative partner for cost allocations
                                                                                                 
          amortization of debt issuance costs
                                                                                         123,000 123,000 125,000 80,000     
          inventory
                                                                                                 
          deposits and other
                                                                                         -25,000 -1,000 -297,000    -1,000 
          proceeds from sale of short-term investments
                                                                                           502,000     
          purchase of short-term investments
                                                                                         6,017,000        
          proceeds from issuance of long-term notes
                                                                                         3,529,000       
          amortization of premiums and discounts
                                                                                                 
          gain on extinguishment of long-term debt
                                                                                          -40,935,000     
          loss on disposal of property and equipment
                                                                                          8,000 1,000 1,000     
          proceeds from sales or maturities of short-term investments
                                                                                                 
          net proceeds from issuance of convertible notes
                                                                                          -4,000       
          prepaid expenses and other
                                                                                              -189,000 -14,000 135,000 
          transfer from restricted cash
                                                                                                 
          loss on disposal/retirement of property and equipment and investments
                                                                                               1,000 2,000 
          purchase of property and equipment, net of sale proceeds
                                                                                                -729,000 
          payments – current notes
                                                                                                -3,014,000 
          principal payments – short-term loan
                                                                                                 
          adjustment to reconcile net loss to net cash from operating activities:
                                                                                                 
          increase in convertible notes to genentech for cost allocations
                                                                                                 
          accrued interest on convertible notes
                                                                                                 
          common shares received from a vendor
                                                                                                 
          change in assets and liabilities:
                                                                                                 
          receivables and related party and other receivables
                                                                                                 
          deposit and other assets
                                                                                                 
          purchase of marketable securities
                                                                                                 
          gain on investments
                                                                                                 
          proceeds from sale and leaseback transactions
                                                                                                 
          principal payments—short-term loan
                                                                                                 
          proceeds from issuance of common or convertible shares and warrants
                                                                                                 
          cash and cash equivalents at beginning of year
                                                                                                 
          cash and cash equivalents at end of year