7Baggers

Xencor, Inc
(NASDAQ:XNCR) 

XNCR stock logo

Xencor, Inc., a clinical stage biopharmaceutical company, focuses on the discovery and development of engineered monoclonal antibody and cytokine therapeutics to treat patients with cancer and autoimmune diseases in the United states and internationally. The company's product candidates include Obex...

Founded: 1997
Full Time Employees: 166
Sector: Healthcare
Industry: Biotechnology
Pharmaceuticals
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Quarterly
Annual
    Unit: USD2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 
                                                    
      revenue
    		                                                
      yoy
    		                                                
      qoq
    		                                                
      collaborations, milestones, and royalties
    		28,237,000 20,999,000 43,608,000 32,732,000 10,118,750 10,710,000 16,960,000 12,805,000 30,912,250 59,164,000 45,523,000 18,962,000 35,742,250 27,299,000 30,175,000 85,495,000                                 
      operating expenses:
    		                                                
      research and development
    		64,824,000 54,367,000 61,665,000 58,578,000 51,056,000 58,226,000 61,531,000 56,873,000 64,220,000 64,939,000 60,060,000 64,379,000 51,452,000 53,273,000 47,084,000 47,756,000 50,988,000 50,610,000 49,497,000 41,411,000 47,949,000 44,452,000 43,458,000 33,943,000 27,340,000 29,770,000 33,299,000 28,183,000 27,130,000 20,953,000 23,332,000 26,087,000 20,396,000 19,408,000 16,919,000 15,048,000 13,360,000 14,069,000 14,408,000 10,035,000 10,877,000 10,582,000 7,476,000 5,205,000 5,052,000 4,953,000 4,283,000 4,228,000 
      general and administrative
    		17,041,000 14,151,000 15,115,000 17,337,000 14,915,000 14,767,000 17,746,000 13,787,000 15,478,000 12,493,000 11,460,000 13,948,000 12,751,000 12,374,000 11,091,000 11,273,000 11,375,000 10,373,000 8,863,000 8,226,000 7,603,000 7,636,000 7,231,000 7,219,000 6,749,000 6,266,000 5,758,000 5,512,000 5,517,000 7,435,000 4,958,000 4,562,000 4,427,000 4,172,000 4,091,000 4,811,000 3,108,000 3,007,000 3,043,000 3,950,000 3,439,000 3,233,000 2,524,000 2,764,000 1,962,000 2,182,000 1,594,000 1,723,000 
      total operating expenses
    		81,865,000 68,518,000 76,780,000 75,915,000 65,971,000 72,993,000 79,277,000 70,660,000 79,698,000 77,432,000 71,520,000 78,327,000 64,203,000 65,647,000 58,175,000 59,029,000 62,363,000 60,983,000 58,360,000 49,637,000 55,552,000 52,088,000 50,689,000 41,162,000 34,089,000 36,036,000 39,057,000 33,695,000 32,647,000 28,388,000 28,290,000 30,649,000 24,823,000 23,580,000 21,010,000 19,859,000 16,468,000 17,076,000 17,451,000 13,985,000 14,316,000 13,815,000 10,000,000 7,969,000 7,014,000 7,135,000 5,877,000 5,951,000 
      operating income
    		-53,628,000 -47,519,000 -33,172,000 -43,183,000                                             
      yoy
    		                                                
      qoq
    		12.86% 43.25% -23.18%                                              
      operating margin %
    		-Infinity% -Infinity% -Infinity% -Infinity% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% 
      other income:
    		                                                
      interest income
    		6,200,000 6,538,000 7,248,000 7,538,000 8,164,000 7,537,000 7,681,000 7,471,000 6,954,000 5,016,000 3,764,000 2,892,000 2,068,000 1,379,000 717,000 653,000 291,000 196,000 147,000 215,000 712,000 1,423,000 2,090,000 3,039,000 3,418,000 3,699,000 3,615,000 2,886,000 2,823,000 2,642,000 2,486,000 1,158,000 1,052,000 1,048,000 1,038,000 1,057,000 785,000 579,000 368,000 359,000 773,000 676,000 290,000 101,000 2,000 2,000 11,000 18,000 
      interest expense
    		-7,354,000 -7,665,000 -8,243,000 -8,665,000 -33,927,000 -795,000 -844,000                              18,000  -10,000 -27,000 -2,000        
      gain on marketable equity securities
    		51,405,000 44,201,000 4,967,000                                              
      asset impairment charges
    		-881,000 -1,565,000 -1,858,000 -4,865,000                                             
      other
    		-8,000 -17,000 -17,000 -31,000                                             
      total other income
    		49,362,000 41,492,000 2,097,000  -56,673,000 15,986,000 -4,974,000 -10,854,000 21,556,000 -6,001,000 4,043,000  30,136,000 6,677,000 -5,975,000 -2,872,000 -18,591,000 1,109,000 43,161,000 13,185,000 7,000 4,172,000 2,582,000 703,000 3,373,000 3,702,000 3,588,000 2,701,000 2,884,000 2,499,000 2,421,000 1,156,000 954,000 1,101,000 1,065,000 1,054,000 804,000 580,000 358,000 335,000 106,750 275,000 118,000 34,000 8,500 9,000 9,000 16,000 
      loss before income tax expense and noncontrolling interest
    		-4,266,000 -6,027,000 -31,075,000 -48,265,000                                             
      income tax expense
    		2,387,000  -250,000 367,000 1,500,000  117,000      -415,000 1,088,000           -288,000 -350,000 50,000 900,000     -1,086,000 173,000 280,000 170,000             
      net loss including noncontrolling interest
    		-6,653,000 -6,027,000 -30,825,000 -48,632,000                                             
      net loss attributable to noncontrolling interest
    		   -214,000                                             
      net loss attributable to xencor, inc.
    		-6,653,000 -6,027,000 -30,825,000 -48,418,000                                             
      net income per share
    		-0.09 -0.08 -0.41 -0.66                                             
      weighted-average shares used for eps calculation
    		74,239 74,413 74,279 73,667                                            31,360,879,000 
      other comprehensive income, net of tax:
    		                                                
      net unrealized gain on marketable debt securities
    		418 900 -97     -1,445,000 1,561,000 1,151,000 1,765,000 3,327,000    -5,611,000                                 
      comprehensive loss
    		-6,235 -5,127 -30,922 -47,614    -70,154,000 -25,185,500 -23,118,000 -20,189,000         -2,464,000           -25,676,000 -29,886,000    -14,390,000    -5,779,000 7,247,000 -9,953,000 -8,923,000 -6,479,000     
      less: comprehensive loss attributable to the noncontrolling interest
    		   -214                                             
      comprehensive loss attributable to xencor, inc.
    		-6,235 -5,127 -30,922 -47,400    -69,478,000                                         
      gains on equity securities
    		   941,000                                             
      total other expense
    		   -5,082,000        -1,398,000                                     
      other comprehensive loss, net of tax:
    		                                                
      net unrealized gains on marketable debt securities
    		   1,018                                             
      operating expenses
    		                                                
      income from operations
    		    4,047,000 -62,283,000 -62,317,000 -57,855,000 -35,009,000 -18,268,000 -25,997,000 -59,365,000 -42,593,000 -38,348,000 -28,000,000 26,466,000 91,652,000 -41,300,000 9,087,000 -15,672,000 -13,698,000 -16,722,000 -37,600,000 -8,777,000 -30,573,000 -14,276,000 -19,572,000 78,244,000 -21,083,000 651,000 -28,290,000 -30,649,000 -13,883,000 -16,490,000 -7,670,000 -15,519,000 -10,028,000 -9,255,000 48,556,000 -6,733,000 7,438,000 -10,312,000 -8,986,000 -6,478,000 -1,350,000 -6,287,000   
      other income
    		    64,000 -10,000 -4,000  -348,750 6,000       -664,000 -593,000 -6,000 12,970,000 -705,000 2,749,000 492,000  -45,000 3,000  -185,000 77,000 -143,000 -62,000 2,000 21,500 56,000 30,000  1,000 3,000  3,000 -452,000 -397,000 -168,000  1,000 9,000 1,000  
      impairment on equity securities
    		      220,000 -20,650,000                                         
      gain on equity securities
    		    -30,974,000 9,254,000 -12,027,000 2,325,000 13,238,000 -11,023,000 288,000  28,110,000 5,299,000 -6,545,000 -3,429,000 -18,218,000 1,506,000 43,020,000                              
      income before income tax expense
    		    -45,574,250 -46,297,000 -67,291,000      -10,512,750 -31,671,000                     -6,605,000              
      net income
    		    -54,126,000 -46,297,000 -67,408,000 -68,709,000 -19,264,000 -24,269,000 -21,954,000 -60,763,000 -12,042,000 -32,759,000 -33,975,000 23,594,000 73,061,000 -40,191,000 52,248,000 -2,487,000 -13,691,000 -12,550,000 -35,018,000 -8,074,000 -26,912,000 -10,224,000 -16,034,000 80,045,000 -18,199,000 3,150,000 -25,869,000 -29,493,000 -11,843,000 -15,562,000 -6,885,000 -14,635,000 -9,065,000 -8,077,000 47,165,000 -6,398,000 7,757,000 -10,037,000 -8,868,000 -6,444,000 -1,349,000 -6,278,000 -5,044,000 -3,751,000 
      yoy
    		    180.97% 90.77% 207.04% 13.08% 59.97% -25.92% -35.38% -357.54% -116.48% -18.49% -165.03% -1048.69% -633.64% 220.25% -249.20% -69.20% -49.13% 22.75% 118.40% -110.09% 47.88% -424.57% -38.02% -371.40% 53.67% -120.24% 275.73% 101.52% 30.65% 92.67% -114.60% 128.74% -216.86% -19.53% -631.86% -0.71% -675.02% 59.88% 75.81% 71.79%     
      qoq
    		    16.91% -31.32% -1.89% 256.67% -20.62% 10.54% -63.87% 404.59% -63.24% -3.58% -244.00% -67.71% -281.78% -176.92% -2200.84% -81.83% 9.09% -64.16% 333.71% -70.00% 163.22% -36.24% -120.03% -539.83% -677.75% -112.18% -12.29% 149.03% -23.90% 126.03% -52.96% 61.45% 12.23% -117.12% -837.18% -182.48% -177.28% 13.18% 37.62% 377.69% -78.51% 24.46% 34.47%  
      net income margin %
    		NaN% NaN% NaN% NaN% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% Infinity% Infinity% -Infinity% Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% Infinity% -Infinity% Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% Infinity% -Infinity% Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% 
      net income attributable to non-controlling interest
    		    -818,750 -1,154,000 -1,445,000 -676,000                                         
      net income attributable to xencor, inc.
    		    -44,784,750 -45,143,000 -65,963,000 -68,033,000                                         
      basic and diluted net income per common share attributable to xencor, inc.
    		    -717.5 -710 -1,070 -1,110                                         
      basic and diluted weighted-average common shares outstanding
    		     64,022,547,000 61,676,444,000 61,212,324,000  60,621,534,000 59,807,558,000         57,997,313,000           55,678,990,000 47,753,922,000                 
      other comprehensive income
    		                                                
      comprehensive loss attributable to non-controlling interest
    		       -676,000                                         
      loss before income tax expense
    		        -26,746,500 -24,269,000                          -14,465,000             
      basic and diluted net loss per common share
    		        -442.5 -400 -370         -40           -460 -620    -310    -160 -165 -250 -220 -190    -120 
      other expense
    		          -9,000 -1,392,000 -61,000 -1,000 -147,000 -96,000        -2,336,000   -27,000                 -63,000     
      loss on equity securities
    		           -2,898,000                                     
      comprehensive income
    		           -57,436,000 -9,118,000 -33,690,000 -35,798,000 17,983,000 71,626,000 -40,250,000 52,136,000  -14,184,000 -13,466,000 -34,591,000 -8,179,000 -27,187,000 -10,417,000 -14,750,000 81,361,000 -16,832,000 2,820,000   -12,554,000 -15,419,000 -6,929,000  -10,256,000 -8,543,000 47,278,000          
      basic net income per common share
    		           -1,020 -180 -550 -570 400 40 -690 900  -242.5 -220 -610 -140 237.5 -180 -280 1,420 -245 60   -197.5 -330 -150  200 -200 1,160          
      diluted net income per common share
    		           -1,020 -180 -550 -570 390 40 -690 870  -242.5 -220 -610 -140 230 -180 -280 1,380 -245 50   -197.5 -330 -150  195 -200 1,130          
      basic weighted-average common shares outstanding
    		           59,771,674,000  59,716,594,000 59,567,139,000 59,407,829,000  58,350,647,000 58,247,941,000   57,266,112,000 57,059,610,000 56,946,714,000  56,643,075,000 56,399,255,000 56,302,967,000  55,974,080,000    46,929,498,000 46,767,759,000   41,033,973,000 40,800,586,000          
      diluted weighted-average common shares outstanding
    		           59,771,674,000  59,716,594,000 59,567,139,000 61,078,494,000  58,350,647,000 60,335,339,000   57,266,112,000 57,059,610,000 56,946,714,000  56,643,075,000 56,399,255,000 58,009,878,000  58,313,002,000    46,929,498,000 46,767,759,000   41,033,973,000 41,738,460,000          
      other comprehensive loss
    		                                                
      net unrealized loss on marketable debt securities
    		            -2,091,500 -931,000 -1,823,000  -37,250 -59,000                               
      collaborations, licenses, milestones, and royalties
    		                154,015,000 19,683,000 67,447,000 33,965,000 20,210,000 35,366,000 13,089,000 32,385,000 38,296,000 21,760,000 19,485,000                      
      net unrealized gain on marketable securities
    		                  -112,000 23,000 -148,500 -916,000 427,000 -105,000 601,750 -193,000 1,284,000 1,316,000 -132,500 -330,000 193,000 -393,000 86,000 143,000 -44,000 245,000 66,500 -466,000 113,000          
      net income before income tax expense
    		                    -13,910,500 -12,550,000 -35,018,000 -8,074,000 13,596,750 -10,574,000                       
      net income before income taxes
    		                          -15,984,000 80,945,000 -13,052,500 3,150,000                   
      collaborations and licenses
    		                           111,939,000                     
      collaborations, licenses and milestones
    		                            11,564,000 29,039,000   10,940,000 7,090,000 13,340,000 4,340,000 6,440,000 7,821,000 66,007,000 7,252,000 21,754,000 3,503,000 1,014,000 1,491,000 964,000 848,000 824,000 2,184,000 
      income before income taxes
    		                              -25,869,000 -29,493,000 -9,114,750 -15,389,000               
      weighted-average common shares outstanding used to compute basic and diluted net loss per share
    		                                   46,598,797    40,626,729  40,473,520 40,389,648 34,297,782     
      income before income tax
    		                                    -9,224,000 -8,675,000 48,914,000          
      provision for income tax
    		                                    287,500 -598,000 1,749,000          
      other comprehensive income, net of tax
    		                                                
      net unrealized gain on marketable securities available-for-sale
    		                                       619,000  84,000       
      net unrealized loss on marketable securities available-for-sale
    		                                          -55,000      
      net unrealized loss on marketable securities
    		                                           -35,000     
      loss on settlement of notes
    		                                                
      deemed contribution (dividend) on exchange of preferred stock
    		                                                
      net income attributable to common stockholders
    		                                            -1,349,000 -6,278,000 -5,044,000  
      net income per share
    		-0.09 -0.08 -0.41 -0.66                                             
      basic
    		                                            -0.04 -0.2 -0.16  
      diluted
    		                                            -0.04 -0.2 -0.16  
      weighted-average shares used for eps calculation
    		74,239 74,413 74,279 73,667                                            31,360,879,000 
      basic
    		        60,503,283    59,652,461    58,379,641    57,212,737    56,531,439    53,942,116    46,817,756    41,267,329    39,015,131    31,390,631 31,395,626 31,372,618  
      diluted
    		        60,503,283    59,652,461    60,495,455    57,212,737    58,467,880    53,942,116    46,817,756    42,388,867    39,015,131    31,390,631 31,395,626 31,372,618  
      deemed contribution on exchange of preferred stock
    		                                                
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 
                                                      
        assets
      		                                                
        current assets:
      		                                                
        cash and cash equivalents
      		54,073,000 28,291,000 44,442,000 39,675,000 40,875,000 29,031,000 30,768,000 31,034,000 53,790,000 52,733,000 34,710,000 72,394,000 53,942,000 52,654,000 49,410,000 78,267,000 143,480,000 41,200,000 115,842,000 176,965,000 163,544,000 58,094,000 109,534,000 73,808,000 50,312,000 51,189,000 32,557,000 21,858,000 26,246,000 34,996,000 35,292,000 251,572,000 16,528,000 13,634,000 11,220,000 13,561,000 14,528,000 14,787,000 7,877,000 8,150,000 12,590,000 57,738,000 11,171,000 119,048,000 54,649,000    
        marketable debt securities
      		381,158,000 358,493,000 358,984,000 381,021,000 408,971,000 435,043,000 449,372,000 460,367,000 497,725,000 412,827,000 476,667,000 475,922,000 526,689,000 515,398,000 435,623,000 278,058,000 153,767,000 199,423,000                               
        marketable equity securities
      		112,502,000 84,260,000 40,438,000 48,870,000 47,929,000 78,903,000 28,271,000 44,535,000 42,210,000 28,972,000 39,995,000 39,706,000 42,431,000 32,184,000 26,885,000 33,430,000 36,860,000                                
        accounts receivable
      		29,299,000 21,805,000 47,554,000 37,785,000 60,849,000 10,205,000 22,073,000 9,580,000 11,290,000 55,000,000 20,019,000 19,861,000 28,997,000 44,876,000 54,284,000 88,204,000 66,384,000 20,545,000 14,825,000 12,525,000 11,443,000 9,534,000 8,925,000 6,825,000 21,574,000 4,349,000 10,130,000 137,676,000 10,187,000 2,462,000 1,283,000 1,098,000 1,142,000 831,000 14,876,000 6,938,000 8,616,000 3,089,000 150,354,000 649,000 44,000 408,000 454,000 411,000 2,966,000 20,000 60,000 511,000 
        prepaid expenses and other current assets
      		22,789,000 25,592,000 21,732,000 13,920,000 18,977,000 20,146,000 23,986,000 16,736,000 18,145,000 21,644,000 22,171,000  23,283,000    23,877,000 20,883,000 15,594,000 14,164,000 10,726,000 10,185,000 7,398,000 6,476,000 6,547,000 7,533,000 11,307,000 9,433,000 10,375,000 12,095,000 12,074,000 6,649,000 5,606,000 7,027,000 7,617,000 4,365,000 2,901,000 3,448,000 2,192,000 1,843,000 1,201,000 865,000 711,000 422,000 134,000 162,000 402,000 159,000 
        total current assets
      		599,821,000 518,441,000 513,150,000 521,271,000 577,601,000 573,328,000 554,470,000 562,252,000 623,160,000 571,176,000 593,562,000 629,976,000 675,342,000 667,998,000 585,936,000 505,970,000 424,368,000 329,629,000 480,967,000 591,168,000 637,672,000 570,883,000 603,386,000 588,107,000 558,405,000 573,765,000 527,009,000 488,671,000 315,727,000 286,920,000 269,527,000 470,919,000 230,879,000 217,810,000 210,982,000 166,089,000 141,653,000 110,842,000 243,651,000 94,851,000 97,675,000 129,876,000 69,720,000 145,068,000 57,749,000 61,105,000 66,680,000 73,206,000 
        restricted cash
      		289,000 288,000 286,000 284,000 387,000 385,000 384,000 382,000 380,000 378,000                                       
        marketable debt securities - long term
      		175,602,000 247,158,000 260,399,000 272,815,000 256,833,000 290,274,000 104,862,000 154,960,000 145,512,000 20,420,000   3,826,000 41,720,000 140,413,000 239,035,000 300,465,000 276,743,000                               
        property and equipment
      		53,308,000 54,587,000 56,791,000 58,808,000 59,800,000 62,400,000 63,868,000 63,540,000 66,124,000 68,035,000 67,997,000 66,685,000 59,183,000 51,040,000 38,855,000 28,411,000 28,240,000 24,179,000 23,132,000 22,301,000 21,682,000 19,771,000 16,239,000 16,799,000 15,805,000 13,868,000 12,128,000 11,456,000 11,813,000 9,688,000 9,401,000 8,921,000 7,088,000 6,085,000 3,861,000 3,360,000 3,105,000 3,050,000 2,508,000 2,510,000 2,310,000 2,293,000 1,804,000 1,375,000 899,000 744,000 571,000 340,000 
        right-of-use assets
      		37,592,000 38,371,000 37,048,000                                              
        patents, licenses, and other intangible assets
      		8,385,000 9,468,000 11,252,000 13,363,000 18,485,000 17,919,000 18,778,000 18,852,000 18,663,000 18,744,000 18,708,000 18,244,000 18,500,000 18,094,000 17,944,000 16,712,000 16,493,000 16,675,000 16,384,000 15,550,000 15,977,000 15,319,000 15,162,000 14,637,000 14,421,000 14,027,000 13,522,000 12,737,000 11,969,000 11,677,000 11,531,000 11,316,000 11,148,000 11,043,000 10,865,000 10,886,000 10,362,000 10,565,000 10,353,000 10,140,000 9,971,000 9,617,000 9,691,000 9,509,000 9,116,000 8,957,000 9,058,000 8,899,000 
        other assets
      		498,000 498,000 498,000 498,000 498,000 498,000 498,000 498,000 648,000 660,000 598,000 599,000 613,000 613,000 613,000 613,000 653,000 33,455,000 4,354,000 10,417,000 212,000 8,608,000 8,788,000 9,188,000 311,000 10,187,000 10,726,000 11,265,000 311,000 311,000 265,000 265,000 265,000 265,000 214,000 103,000 103,000 103,000 103,000 103,000 63,000 63,000 64,000 59,000 59,000 60,000 58,000 50,000 
        total assets
      		875,495,000 868,811,000 879,424,000 904,689,000 951,945,000 983,635,000 826,167,000 884,255,000 952,692,000 778,430,000 778,121,000 803,411,000 846,266,000 835,269,000 851,325,000 857,922,000 838,211,000 697,264,000 695,602,000 692,737,000 703,244,000 646,349,000 644,720,000 666,963,000 670,250,000 686,244,000 684,753,000 697,003,000 576,732,000 585,586,000 591,457,000 612,272,000 390,102,000 398,255,000 416,164,000 418,303,000 428,563,000 322,130,000 334,281,000 193,961,000 206,910,000 211,481,000 172,563,000 178,639,000 67,823,000 70,866,000 76,367,000 82,495,000 
        liabilities and stockholders’ equity
      		                                                
        current liabilities:
      		                                                
        accounts payable
      		10,828,000 9,079,000 18,533,000 16,191,000 16,759,000 18,770,000 15,838,000 16,011,000 13,914,000 14,967,000 14,097,000 15,341,000 10,088,000 14,618,000 15,747,000 11,905,000 14,001,000 9,131,000 7,112,000 7,663,000 8,954,000 13,109,000 10,513,000 10,313,000 10,189,000 8,304,000 8,994,000 5,485,000 3,797,000 5,983,000 4,916,000 8,523,000 6,869,000 6,602,000 7,379,000 4,275,000 3,880,000 7,334,000 7,694,000 4,291,000 6,400,000 5,107,000 3,077,000 2,556,000 1,691,000 2,098,000 1,374,000 2,104,000 
        accrued expenses
      		34,960,000 28,108,000 23,884,000 16,063,000 19,217,000 25,407,000 19,557,000 13,491,000 23,564,000 24,472,000 18,440,000 15,140,000 18,728,000 19,289,000 16,348,000 12,612,000 19,443,000 22,108,000 17,328,000 12,513,000 17,603,000 11,381,000 9,157,000 7,292,000 8,995,000 7,832,000 6,226,000 5,705,000 9,662,000 5,671,000 5,923,000 4,611,000 5,480,000 4,636,000 3,984,000 6,502,000 6,692,000 6,536,000 3,278,000 2,391,000 3,634,000 3,817,000 2,537,000 1,686,000 2,251,000 1,764,000 1,331,000 1,465,000 
        income tax payable
      		3,589,000       5,782,000 5,782,000     388,000            400,000       157,000                
        lease liabilities
      		3,263,000 3,936,000 3,380,000 3,640,000 3,009,000 2,181,000 1,262,000 2,079,000 3,435,000 4,380,000 4,228,000 4,471,000 4,708,000 20,551,000 7,647,000 936,000  128,000 2,322,000 1,934,000 1,889,000 2,158,000 2,094,000 2,136,000 2,169,000 2,197,000 2,214,000 1,987,000                     
        liabilities related to the sales of future royalties
      		43,267,000 45,362,000 50,286,000 52,542,000                                             
        total current liabilities
      		95,907,000 86,485,000 96,083,000 88,436,000 87,432,000 91,972,000 80,076,000 79,402,000 84,709,000 53,041,000 44,630,000 65,056,000 63,844,000 90,032,000 75,041,000 60,941,000 70,738,000 44,317,000 45,962,000 99,931,000 121,061,000 70,488,000 66,449,000 65,917,000 66,558,000 64,312,000 63,712,000 73,321,000 53,853,000 52,027,000 71,156,000 73,431,000 101,345,000 100,326,000 107,431,000 106,875,000 106,286,000 110,666,000 115,953,000 34,255,000 43,429,000 56,576,000 8,408,000 6,877,000 6,196,000 9,930,000 5,946,000 6,827,000 
        long-term tax liabilities
      		2,784,000                                                
        lease liabilities, net of current portion
      		64,735,000 65,331,000 64,551,000 64,184,000 65,338,000 66,489,000 67,156,000 66,810,000 59,025,000 56,379,000 54,615,000 54,772,000 54,926,000 22,539,000 33,943,000 33,958,000 33,969,000 34,087,000 2,702,000 9,194,000 9,739,000 7,378,000 7,626,000 8,041,000 8,565,000 9,082,000 9,650,000 10,221,000                     
        liabilities related to the sales of future royalties, net of current portion
      		76,482,000 87,776,000 94,736,000 101,837,000                                             
        total liabilities
      		239,908,000 243,495,000 259,073,000 264,815,000 277,919,000 262,737,000 263,626,000 272,068,000 283,559,000 109,420,000 99,245,000 119,828,000 118,770,000 112,571,000 108,984,000 94,899,000 104,707,000 78,404,000 48,664,000 109,125,000 130,800,000 77,866,000 74,075,000 73,958,000 77,049,000 76,007,000 76,662,000 87,438,000 55,051,000 53,313,000 72,278,000 74,608,000 108,056,000 107,716,000 114,799,000 114,555,000 114,609,000 119,710,000 125,684,000 35,148,000 44,478,000 58,166,000 10,495,000 9,337,000 8,533,000 11,157,000 10,851,000 12,430,000 
        commitments and contingencies
      		                                                
        noncontrolling interest and stockholders’ equity
      		                                                
        common stock
      		718,000 714,000 714,000 712,000 703,000 701,000 619,000 617,000 611,000 607,000 607,000 605,000 601,000 598,000 598,000 596,000 595,000 585,000 584,000 583,000 580,000 573,000 572,000 570,000 569,000 567,000 565,000 564,000 563,000 562,000 558,000 556,000 470,000 470,000 468,000 467,000 466,000 411,000 409,000 407,000 405,000 405,000 405,000 404,000 314,000 314,000 314,000 314,000 
        additional paid-in capital
      		1,429,252,000 1,412,750,000 1,402,658,000 1,391,261,000 1,381,607,000 1,364,846,000 1,162,726,000 1,144,468,000 1,131,266,000 1,114,383,000 1,101,131,000 1,085,651,000 1,072,132,000 1,058,219,000 1,044,172,000 1,029,058,000 1,017,523,000 974,514,000 962,343,000 951,154,000 937,525,000 919,387,000 908,084,000 895,855,000 887,873,000 877,724,000 865,163,000 851,888,000 845,366,000 839,127,000 828,858,000 821,670,000 570,670,000 566,609,000 562,017,000 557,473,000 552,889,000 431,154,000 428,790,000 426,286,000 424,128,000 422,258,000 421,058,000 419,370,000 302,969,000 302,039,000 301,568,000 301,073,000 
        accumulated other comprehensive income
      		1,576,000 1,158,000 258,000 355,000 -663,000 1,800,000 -652,000 -154,000 1,291,000    -6,952,000    -1,510,000 -74,000 -15,000 97,000 74,000 567,000 1,483,000 1,056,000 1,161,000 1,436,000 1,629,000 345,000           216,000 103,000    -35,000     
        accumulated deficit
      		-795,959,000 -789,306,000 -783,279,000 -752,454,000 -704,036,000 -643,511,000 -598,368,000 -532,405,000 -464,372,000 -445,271,000 -421,002,000 -399,048,000 -338,285,000 -326,244,000 -293,485,000 -259,510,000 -283,104,000 -356,165,000 -315,974,000 -368,222,000 -365,735,000 -352,044,000 -339,494,000 -304,476,000 -296,402,000 -269,490,000 -259,266,000 -243,232,000 -323,277,000 -305,078,000 -308,229,000 -282,361,000 -287,286,000 -275,443,000 -259,880,000 -252,996,000 -237,960,000 -228,895,000 -220,818,000 -267,983,000 -261,585,000 -269,342,000 -259,305,000 -250,437,000 -243,993,000 -242,644,000   
        total stockholders’ equity attributable to xencor, inc.
      		635,587,000 625,316,000 620,351,000 639,874,000 677,611,000 723,836,000 564,325,000 612,526,000 668,796,000                                        
        noncontrolling interest
      		                                                
        total noncontrolling interest and stockholders’ equity
      		635,587,000 625,316,000 620,351,000 639,874,000                                             
        total liabilities and stockholders’ equity
      		875,495,000 868,811,000 879,424,000 904,689,000 951,945,000 983,635,000 826,167,000 884,255,000 952,692,000 778,430,000 778,121,000 803,411,000 846,266,000 835,269,000 851,325,000 857,922,000 838,211,000 697,264,000 695,602,000 692,737,000 703,244,000 646,349,000 644,720,000 666,963,000 670,250,000 686,244,000 684,753,000 697,003,000 576,732,000 585,586,000 591,457,000 612,272,000 390,102,000 398,255,000 416,164,000 418,303,000 428,563,000 322,130,000 334,281,000 193,961,000 206,910,000 211,481,000 172,563,000 178,639,000 67,823,000 70,866,000 76,367,000 82,495,000 
        uncertain tax position payable
      		 3,903,000 3,703,000 10,358,000 9,990,000                                            
        right-of-use asset
      		   37,650,000                                             
        current assets
      		                                                
        marketable equity securities - long term
      		      43,780,000 43,560,000  64,210,000 64,210,000 54,210,000  31,124,000 31,124,000 31,262,000 31,262,000                                
        right of use asset
      		    38,341,000    33,995,000    34,419,000    31,730,000    10,600,000    9,380,000                        
        current liabilities
      		                                                
        debt
      		    48,447,000 7,749,000 6,947,000 7,951,000 6,332,000                                        
        debt, net of current portion
      		    115,159,000 10,169,000 12,313,000 12,489,000 14,642,000                                        
        stockholders’ equity
      		                                                
        preferred stock, 0.01 par value: 10,000,000 authorized shares; -0- issued and outstanding shares at december 31, 2024 and 2023
      		                                                
        non-controlling interest
      		    -3,585,000 -2,938,000 -1,784,000 -339,000 337,000                                        
        total stockholders' equity
      		    674,026,000    669,133,000                                        
        right of use (rou) asset
      		     38,831,000 39,527,000 40,211,000  34,807,000 33,046,000 33,697,000  19,680,000 31,440,000 30,919,000                                 
        deferred income
      		     37,865,000 36,472,000 34,088,000 31,682,000                                        
        deferred income, net of current portion
      		     94,107,000 104,081,000 113,367,000 125,183,000                                        
        preferred stock, 0.01 par value: 10,000,000 authorized shares; -0- issued and outstanding shares at september 30, 2024 and december 31, 2023
      		                                                
        total stockholders’ equity
      		     720,898,000 562,541,000 612,187,000  669,010,000 678,876,000 683,583,000 727,496,000 722,698,000 742,341,000 763,023,000 733,504,000 618,860,000 646,938,000 583,612,000 572,444,000 568,483,000 570,645,000 593,005,000 593,201,000 610,237,000 608,091,000 609,565,000 521,681,000 532,273,000 519,179,000 537,664,000 282,046,000 290,539,000 301,365,000 303,748,000 313,954,000 202,420,000 208,597,000 158,813,000 162,432,000 153,315,000 162,068,000 169,302,000 59,290,000 59,709,000 65,516,000 70,065,000 
        preferred stock, 0.01 par value: 10,000,000 authorized shares; -0- issued and outstanding shares at june 30, 2024 and december 31, 2023
      		                                                
        preferred stock, 0.01 par value: 10,000,000 authorized shares; -0- issued and outstanding shares at march 31, 2024 and december 31, 2023
      		                                                
        equity securities
      		        64,210,000    54,383,000     47,578,000 45,230,000 6,136,000 5,303,000 5,382,000 2,611,000 2,253,000                         
        deferred revenue
      		         9,222,000 7,865,000 30,104,000 30,320,000 35,186,000 35,299,000 35,488,000 37,294,000 12,950,000 19,200,000 77,821,000 92,615,000 43,840,000 44,685,000 46,176,000 45,205,000 45,579,000 45,478,000 59,244,000  40,079,000 60,118,000 60,118,000                 
        preferred stock, 0.01 par value: 10,000,000 authorized shares; -0- issued and outstanding shares at december 31, 2023 and 2022
      		                                                
        preferred stock, 0.01 par value: 10,000,000 authorized shares; -0- issued and outstanding shares at september 30, 2023 and december 31, 2022
      		                                                
        accumulated other comprehensive loss
      		         -709,000 -1,860,000 -3,625,000  -9,875,000 -8,944,000 -7,121,000             -971,000 -2,338,000 -2,008,000 -2,201,000 -1,808,000 -1,097,000 -1,240,000 -1,196,000 -1,441,000    -516,000  -90,000      
        preferred stock, 0.01 par value: 10,000,000 authorized shares; -0- issued and outstanding shares at june 30, 2023 and december 31, 2022
      		                                                
        prepaid expenses
      		           22,093,000  22,886,000 19,734,000 23,011,000                                 
        notes receivable - long term
      		             5,000,000 5,000,000 5,000,000 5,000,000                                
        preferred stock, 0.01 par value: 10,000,000 authorized shares; -0- issued and outstanding shares at march 31, 2023 and december 31, 2022
      		                                                
        preferred stock, 0.01 par value: 10,000,000 authorized shares; -0- issued and outstanding shares at december 31, 2022 and 2021
      		                                                
        preferred stock, 0.01 par value: 10,000,000 authorized shares; -0- issued and outstanding shares at september 30, 2022 and december 31, 2021
      		                                                
        preferred stock, 0.01 par value: 10,000,000 authorized shares; -0- issued and outstanding shares at june 30, 2022 and december 31, 2021
      		                                                
        contract asset
      		               5,000,000   500,000 12,500,000 12,500,000     15,000,000                       
        preferred stock, 0.01 par value: 10,000,000 authorized shares; -0- issued and outstanding shares at march 31, 2022 and december 31, 2021
      		                                                
        preferred stock, 0.01 par value: 10,000,000 authorized shares; -0- issued and outstanding shares at december 31, 2021 and 2020
      		                                                
        equity securities - long term
      		                 16,583,000 17,146,000 28,219,000 16,071,000                            
        preferred stock, 0.01 par value: 10,000,000 authorized shares; -0- issued and outstanding shares at september 30, 2021 and december 31, 2020
      		                                                
        marketable securities
      		                  288,976,000 368,878,000 434,156,000 487,688,000 474,114,000 497,841,000 479,470,000 495,292,000 472,613,000 318,498,000 268,115,000 236,605,000 220,116,000 210,838,000 207,603,000 196,318,000 177,269,000 141,225,000 115,608,000 89,518,000 83,228,000 84,209,000 83,840,000 70,206,000 56,714,000 25,187,000     
        marketable securities - long term
      		                  153,619,000 25,082,000 1,030,000 31,768,000 1,145,000 38,232,000 71,526,000 73,995,000 120,966,000 172,472,000 236,108,000 276,228,000 299,971,000 120,089,000 139,198,000 163,052,000 190,242,000 237,865,000 273,340,000 197,570,000 77,666,000 86,357,000 96,891,000 69,632,000 91,284,000 22,628,000     
        preferred stock, 0.01 par value: 10,000,000 authorized shares; -0- issued and outstanding shares at june 30, 2021 and december 31, 2020
      		                                                
        preferred stock, 0.01 par value: 10,000,000 authorized shares; -0- issued and outstanding shares at march 31, 2021 and december 31, 2020
      		                                                
        income tax receivable
      		                      804,000 904,000 502,000 402,000 402,000 1,206,000 804,000 762,000 762,000 762,000 1,524,000                
        deferred revenue, net of current portion
      		                        1,926,000 2,613,000 3,300,000 3,896,000                     
        preferred stock, 0.01 par value: 10,000,000 authorized shares; -0- issued and outstanding shares at december 31, 2020 and 2019
      		                                                
        preferred stock, 0.01 par value: 10,000,000 authorized shares; -0- issued and outstanding shares at september 30, 2020 and december 31, 2019
      		                                                
        preferred stock, 0.01 par value: 10,000,000 authorized shares; -0- issued and outstanding shares at june 30, 2020 and december 31, 2019
      		                                                
        preferred stock, 0.01 par value: 10,000,000 authorized shares; -0- issued and outstanding shares at march 31, 2020 and december 31, 2019
      		                                                
        deferred rent
      		                                                
        deferred rent, net of current portion
      		                                                
        preferred stock, 0.01 par value: 10,000,000 authorized shares; -0- issued and outstanding shares at december 31, 2019 and 2018
      		                                                
        preferred stock, 0.01 par value: 10,000,000 authorized shares; -0- issued and outstanding shares at september 30, 2019 and december 31, 2018
      		                                                
        income tax liability
      		                          800,000 900,000                     
        preferred stock, 0.01 par value: 10,000,000 authorized shares; -0- issued and outstanding shares at june 30, 2019 and december 31, 2018
      		                                                
        preferred stock, 0.01 par value: 10,000,000 authorized shares; -0- issued and outstanding shares at march 31, 2019 and december 31, 2018
      		                                                
        loan receivable
      		                                                
        interest receivable
      		                                         659,000 670,000      
        current portion of deferred rent
      		                            315,000 294,000 199,000 179,000 26,000   135,000 128,000 122,000 137,000 113,000 108,000   19,000     
        current portion of deferred revenue
      		                            40,079,000    88,813,000 89,088,000 95,613,000 95,788,000 95,521,000 96,274,000 103,063,000 27,460,000 33,287,000 47,652,000 2,794,000 2,616,000 2,254,000 6,066,000 3,236,000 3,251,000 
        deferred rent, less current portion
      		                            1,198,000 1,286,000 1,122,000 1,177,000 1,088,000 1,202,000 614,000 361,000 397,000 431,000 424,000 476,000 507,000 659,000 703,000 576,000     
        preferred stock, 0.01 par value: 10,000,000 authorized shares; -0- issued and outstanding shares at december 31, 2018 and 2017
      		                                                
        income taxes
      		                                  455,000 175,000 65,000 400,000 1,781,000          
        preferred stock, 0.01 par value: 10,000,000 authorized shares; -0- issued and outstanding shares at september 30, 2018 and december 31, 2017
      		                                                
        preferred stock, 0.01 par value: 10,000,000 authorized shares; -0- issued and outstanding shares at june 30, 2018 and december 31, 2017
      		                                                
        preferred stock, 0.01 par value: 10,000,000 authorized shares; -0- issued and outstanding shares at march 31, 2018 and december 31, 2017
      		                                                
        deferred revenue, less current portion
      		                                5,623,000 6,188,000 6,754,000 7,319,000 7,926,000 8,613,000 9,307,000 417,000 542,000 931,000 1,384,000 1,884,000 2,337,000 1,227,000 4,905,000 5,603,000 
        preferred stock, 0.01 par value: 10,000,000 authorized shares; -0- issued and outstanding shares at december 31, 2017 and 2016
      		                                                
        preferred stock, 0.01 par value: 10,000,000 authorized shares; -0- issued and outstanding shares at september 30, 2017 and december 31, 2016
      		                                                
        preferred stock, 0.01 par value: 10,000,000 authorized shares; -0- issued and outstanding shares at june 30, 2017 and december 31, 2016
      		                                                
        preferred stock, 0.01 par value: 10,000,000 authorized shares; -0- issued and outstanding shares at march 31, 2017 and december 31, 2016
      		                                                
        preferred stock, 0.01 par value: 10,000,000 authorized shares; -0- issued and outstanding shares at december 31, 2016 and 2015
      		                                                
        preferred stock, 0.01 par value: 10,000,000 authorized shares; -0- issued and outstanding shares at september 30, 2016 and december 31, 2015
      		                                                
        accumulated other comprehensive income loss
      		                                     -250,000           
        preferred stock, 0.01 par value: 10,000,000 authorized shares; -0- issued and outstanding shares at june 30, 2016 and december 31, 2015
      		                                                
        preferred stock, 0.01 par value: 10,000,000 authorized shares; -0- issued and outstanding shares at march 31, 2016 and december 31, 2015
      		                                                
        preferred stock, 0.01 par value: 10,000,000 authorized shares; -0- issued and outstanding shares at december 31, 2015 and 2014
      		                                                
        computers, software and equipment
      		                                         5,275,000 5,073,000 4,836,000 4,270,000 4,053,000 3,831,000 3,580,000 
        furniture and fixtures
      		                                         102,000 102,000 102,000 97,000 97,000 97,000 89,000 
        leasehold improvements
      		                                         3,612,000 3,204,000 3,090,000 3,086,000 3,083,000 3,081,000 3,081,000 
        less accumulated depreciation and amortization
      		                                         -6,696,000 -6,575,000 -6,653,000 -6,554,000 -6,489,000   
        total other assets
      		                                         79,312,000 101,039,000 32,196,000 9,175,000 9,017,000 9,116,000 8,949,000 
        current portion of capital lease obligations
      		                                             2,000 5,000 7,000 
        capital lease obligations, less current portion
      		                                                
        cash
      		                                             60,923,000 66,218,000 72,536,000 
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 
                                                        
          cash flows from operating activities
        		                                                
          net loss including noncontrolling interest
        		                                                
          adjustments to reconcile net loss to net cash from operating activities:
        		                                                
          depreciation and amortization
        		2,577,000 2,589,000 2,653,000 2,693,000 2,994,000 3,054,000 3,024,000 3,035,000 3,228,000 3,140,000 2,885,000 2,245,000 2,159,000 2,238,000 2,224,000 2,178,000 2,107,000 1,993,000 1,753,000 1,638,000 1,532,000 1,446,000 1,443,000 1,373,000 1,225,000 1,070,000 1,007,000 996,000 883,000 816,000 822,000 730,000 610,000 556,000 454,000 410,000 467,000 371,000 346,000 282,000 345,000 274,000 254,000 240,000 261,000 135,000 166,000 320,000 
          accretion of discount on marketable debt securities
        		-340,000 -1,652,000 637,000 -2,126,000  -3,467,000 -4,436,000 -5,601,000                                         
          stock-based compensation
        		10,185,000 10,092,000 10,737,000 12,213,000 12,332,000 12,338,000 17,190,000 11,421,000 14,697,000 12,896,000 13,563,000 12,599,000 12,745,000 12,760,000 12,603,000 10,805,000 10,389,000 8,943,000 9,350,000 8,293,000 8,558,000 8,318,000 8,231,000 6,512,000 7,178,000 9,514,000 9,303,000 5,856,000 5,075,000 6,120,000 4,882,000 4,471,000 3,440,000 3,604,000 3,449,000 3,158,000 1,990,000 1,865,000 2,033,000 1,960,000 1,483,000 1,086,000 1,193,000 1,107,000 751,000 471,000 361,000 278,000 
          gain on sale of marketable securities
        		-9,415,000 407,000                                               
          change in fair value of marketable equity securities
        		-41,990,000 -44,608,000                                               
          asset impairment charges
        		881,000 1,565,000 1,858,000 4,865,000                                             
          non-cash royalty revenue related to the sale of future royalties
        		-22,438,000 -20,997,000                                               
          non-cash interest expense on liabilities related to the sale of future royalties
        		7,352,000 7,663,000                                               
          equity received in connection with license agreement
        		                    -22,071,000 0 0 -4,589,000                         
          abandonment of capitalized intangibles
        		                                                
          loss on disposal of assets
        		    1,571,000 0 0 6,000 -1,000 1,000 0 1,379,000 13,000 7,000 8,000 117,000 445,000 21,000   0 -1,000   0 3,000   -8,000                    
          changes in operating assets and liabilities:
        		                                                
          accounts receivable
        		-5,798,000 19,896,000 -8,769,000 23,405,000 -33,758,000 11,868,000           -45,839,000 -5,720,000 -2,300,000 -1,082,000 -1,909,000 -609,000 -2,100,000 14,749,000 -17,224,000 5,781,000 127,611,000 -127,489,000 -7,725,000 -1,180,000 -184,000 44,000 -311,000 14,045,000 -7,938,000 1,678,000 -5,528,000 147,266,000 -149,706,000 -604,000 364,000 45,000 -42,000 2,555,000 -2,947,000    
          interest receivable from marketable debt securities
        		    -310,000 -1,426,000 -395,000 -1,310,000 -1,141,000 -307,000 172,000 248,000 -138,000 56,000 -197,000 -251,000                                 
          prepaid expenses and other assets
        		680,000 5,257,000 -1,553,000 5,057,000 2,010,000 3,840,000 -7,250,000 1,559,000 3,511,000 465,000 -77,000 1,204,000 -397,000 -3,152,000 3,277,000 906,000  -5,290,000 -1,430,000 -3,438,000  -2,786,000 -914,000 71,000  3,775,000 -1,874,000 942,000  -67,000 -5,425,000 -1,043,000  756,000 -3,262,000 -1,465,000  -1,257,000 -348,000 -683,000         
          accounts payable
        		1,691,000 -9,454,000 4,378,000 -568,000 -2,011,000 2,932,000 -173,000 2,097,000 -1,053,000 870,000 -1,245,000 5,254,000 -4,530,000 -1,129,000 3,842,000 -2,096,000 4,870,000 2,019,000 -551,000 -1,291,000 -4,155,000 2,596,000 200,000 124,000 1,884,000 -689,000 3,508,000 1,689,000 -2,186,000 1,067,000 -3,607,000 1,654,000 267,000 -778,000 3,105,000 395,000 -3,454,000 -360,000 3,403,000 -2,109,000 1,293,000 2,030,000 688,000 699,000 -407,000    
          accrued expenses
        		6,942,000 4,223,000 5,785,000 -3,154,000 -6,190,000 5,850,000 6,066,000 -10,073,000 -908,000 6,032,000 3,300,000 -3,588,000 -561,000 2,941,000 3,736,000 -6,831,000 -2,665,000 4,780,000 4,815,000 -5,090,000 6,222,000 2,224,000 1,865,000 -1,703,000 1,163,000 1,606,000 521,000 -3,957,000 3,990,000 -251,000 1,312,000 -869,000 844,000 652,000 -2,518,000 -190,000 156,000 3,259,000 886,000 -1,243,000 -183,000 1,280,000 851,000 -523,000 487,000   72,000 
          income taxes
        		    1,298,000 0                804,000    -400,000 704,000 900,000  1,000 0 -157,000  -455,000 280,000 110,000  -1,381,000           
          operating lease
        		-490,000 13,000 709,000 168,000                                             
          deferred revenue
        		        -9,222,000 1,357,000 -22,239,000 -216,000 -4,866,000 -113,000 -189,000 -1,806,000 24,344,000 -6,250,000 -58,621,000 -14,794,000 48,775,000 -845,000 -1,491,000 -955,000 -1,061,000 -586,000 -14,362,000 23,061,000 0    -840,000 -7,091,000 -740,000 -340,000 -1,440,000 -7,483,000 84,493,000 -5,952,000 -14,755,000 44,406,000 -322,000 -91,000 -2,702,000    
          other assets and liabilities
        		-1,106,000 216,000                                               
          net cash from operating activities
        		-51,711,000 -30,817,000 -36,369,000 -16,220,000 -55,575,000 -26,018,000 -65,337,000 -55,258,000 181,206,000 -27,281,000 -38,200,000 -30,614,000 -24,431,000 -1,168,000 44,269,000 5,815,000 61,790,000 -39,023,000 -9,654,000 -29,966,000 17,084,000 -3,866,000 -27,682,000 9,460,000 -19,577,000 -6,477,000 109,156,000 -18,728,000 -16,781,000 -10,311,000 -28,419,000 -24,245,000 -6,666,000 -3,509,000 -12,788,000 -10,720,000 -15,788,000 134,074,000 -9,369,000 -14,300,000 -3,845,000 39,520,000 -6,916,000 -2,093,000 -5,864,000    
          capital expenditures
        		-1,140,000 -183,000 -383,000 -1,444,000 -1,664,000 -1,275,000 -3,026,000 -132,000 -980,000 -2,832,000 -3,853,000 -10,783,000 -9,966,000 -14,085,000 -12,354,000 -2,089,000 -6,320,000 -2,745,000 -2,283,000 -1,951,000 -3,149,000 -4,695,000 -622,000 -2,073,000 -2,910,000 -2,576,000 -1,452,000 -415,000 -2,787,000 -1,009,000 -1,070,000 -2,346,000 -1,477,000 -2,578,000 -762,000 -494,000 -274,000 -740,000 -176,000 -317,000 -206,000 -609,000 -540,000 -575,000 -220,000    
          free cash flows
        		-52,851,000 -31,000,000 -36,752,000 -17,664,000 -57,239,000 -27,293,000 -68,363,000 -55,390,000 180,226,000 -30,113,000 -42,053,000 -41,397,000 -34,397,000 -15,253,000 31,915,000 3,726,000 55,470,000 -41,768,000 -11,937,000 -31,917,000 13,935,000 -8,561,000 -28,304,000 7,387,000 -22,487,000 -9,053,000 107,704,000 -19,143,000 -19,568,000 -11,320,000 -29,489,000 -26,591,000 -8,143,000 -6,087,000 -13,550,000 -11,214,000 -16,062,000 133,334,000 -9,545,000 -14,617,000 -4,051,000 38,911,000 -7,456,000 -2,668,000 -6,084,000    
          cash flows from investing activities
        		                                                
          purchase of marketable debt securities
        		-37,850,000 -84,235,000            -110,910,000                                   
          purchase of property and equipment
        		-1,140,000 -183,000 -383,000 -1,444,000 -1,664,000 -1,275,000 -3,026,000 -132,000 -980,000 -2,832,000 -3,853,000 -10,783,000 -9,966,000 -14,085,000 -12,354,000 -2,089,000 -6,320,000 -2,745,000 -2,283,000 -1,951,000 -3,149,000 -4,695,000 -622,000 -2,073,000 -2,910,000 -2,576,000 -1,452,000 -415,000 -2,787,000 -1,009,000 -1,070,000 -2,346,000 -1,477,000 -2,578,000 -762,000 -494,000 -274,000 -740,000 -176,000 -317,000 -206,000 -609,000 -540,000 -575,000 -220,000    
          purchase of patents
        		                                                
          proceeds from sales of marketable equity securities
        		23,163,000 379,000                                               
          proceeds from sales and maturities of marketable debt securities
        		87,000,000 98,707,000                                               
          proceeds from sale of property and equipment
        		                15,000 0                       0 0 8,000 1,000 1,000 0   
          net cash from investing activities
        		71,173,000 14,668,000 40,476,000 13,668,000 57,252,000 -163,458,000 66,016,000 32,318,000 -203,130,000 45,326,000 -1,405,000 48,144,000 24,548,000 3,125,000 -75,639,000 -71,759,000 7,860,000 -38,848,000 -53,309,000 38,048,000 78,779,000 -50,560,000 59,408,000 12,565,000 15,727,000 22,060,000 -102,430,000 13,673,000 6,866,000 5,862,000 -190,169,000 12,674,000 8,939,000 4,933,000 9,351,000 8,727,000 -104,271,000 -127,665,000 8,623,000 9,660,000 -41,690,000 6,933,000 -101,291,000 -49,058,000 -587,000    
          cash flows from financing activities
        		                                                
          proceeds from the exercises of stock options
        		5,693,000 0 0 2,974,000                                             
          proceeds from issuance of common stock under the employee stock purchase plan
        		628,000 0    0    0    0    0    0    0    0    1,000    0    0    -7,000   
          proceeds from issuance of common stock and pre-funded warrants
        		    0                                            
          common stock and pre-funded warrants issuance costs
        		    0                                            
          proceeds from the sale of future royalties
        		                                                
          proceeds from noncontrolling interest
        		                                                
          cash paid to acquire noncontrolling interest
        		0 0 0 -1,725,000                                             
          net cash from financing activities
        		6,321,000 0 662,000 1,249,000 10,169,000 187,740,000 -943,000 186,000 22,983,000 356,000 1,921,000 922,000 1,171,000 1,287,000 2,513,000 731,000 32,630,000 3,229,000 1,840,000 5,339,000 9,587,000 2,986,000 4,000,000 1,471,000 2,973,000 3,049,000 3,973,000 667,000 1,165,000 4,153,000 2,308,000 246,615,000 621,000 990,000 1,096,000 1,026,000 119,800,000 501,000 473,000 200,000 387,000 114,000 330,000 115,550,000 177,000 -2,000 131,000 2,000 
          net increase in cash, cash equivalents, and restricted cash
        		       -22,754,000                                         
          cash, cash equivalents, and restricted cash, beginning of period
        		0 0 0 41,262,000  0 0 54,170,000                                         
          cash, cash equivalents, and restricted cash, end of period
        		25,783,000 -16,149,000 4,769,000 39,959,000  -1,736,000 -264,000 31,416,000                                         
          net loss
        		 -6,027,000 -30,825,000 -48,632,000  -46,297,000 -67,408,000 -68,709,000  -24,269,000          -2,487,000          3,151,000 -25,868,000 -29,493,000    -14,635,000    -6,398,000 7,757,000 -10,037,000 -8,868,000 -6,444,000   -5,044,000 -3,751,000 
          net decrease in cash, cash equivalents, and restricted cash
        		   -1,303,000  -1,736,000                                           
          supplemental disclosure of cash flow information
        		                                                
          interest paid
        		 2,000 1,000 1,000                                             
          income taxes paid
        		 359,000                                               
          gain on sale of marketable debt securities
        		     0 0 -3,000                                         
          change in fair value of equity securities
        		   -941,000 30,974,000 -9,254,000 12,027,000 -2,325,000 -13,238,000 11,023,000 -288,000 2,898,000 -28,110,000 -5,298,000 6,545,000 3,429,000 18,218,000 -1,505,000                               
          non-cash royalty revenue
        		   -18,232,000                                             
          non-cash interest expense on liability related to the sale of future royalties
        		   8,664,000                                             
          others
        		   368,000                                             
          purchase of marketable securities
        		   -103,873,000 -54,210,000 -281,714,000 -122,598,000 -136,532,000 -338,425,000 -167,765,000 -181,487,000 -95,228,000    -88,764,000 -121,771,000 -156,367,000 -147,320,000 -84,139,000 -166,348,000 -174,991,000 -159,842,000 -142,477,000 -144,681,000 -107,675,000 -194,643,000 -49,856,000 -46,714,000 -45,317,000 -254,112,000 -31,697,000 -27,326,000 -15,763,000 -26,452,000 -6,988,000 -114,002,000 -195,024,000 9,217,000 -16,340,000 -47,309,000 -20,161,000 -100,415,000 -47,913,000     
          proceeds from maturities of marketable securities
        		   118,985,000  117,975,000 188,024,000 159,942,000               220,801,000 157,653,000  133,079,000 94,778,000 64,995,000                     
          proceeds from sale of marketable securities
        		     0 0 9,969,000                                         
          consolidated net loss
        		                                                
          (accretion of discount) amortization of premium on marketable debt securities
        		         -3,866,000                                       
          abandonment of capitalized intangible assets
        		    150,000 1,395,000 369,000 415,000 470,000 203,000 273,000 321,000 179,000 284,000 736,000 311,000 207,000 417,000 117,000 193,000 132,000 236,000 139,000 28,000 106,000 25,000 32,000 58,000 121,000 68,000 45,000 5,000 123,000 48,000 216,000 9,000 249,000 62,000 36,000 9,000 16,000 226,000 17,000 37,000 13,000 365,000 121,000 10,000 
          gain on sale of available-for-sale marketable debt securities
        		                                                
          impairment on equity securities
        		    0 0 -220,000 20,650,000      0                                   
          noncash royalty revenue related to sale of future royalties
        		                                                
          noncash interest expense
        		                                                
          lease liabilities and rou assets
        		    167,000 948,000 213,000 213,000 2,513,000 155,000 251,000 331,000 1,805,000 13,260,000 6,175,000 1,736,000        -54,000 -49,000 -45,000 194,000 1,254,000                     
          proceeds from maturities of marketable debt securities available-for-sale
        		                                                
          proceeds from sale of marketable debt securities available-for-sale
        		                                                
          proceeds from sale of equity securities
        		                                                
          purchase of intangible assets
        		       -929,000 -726,000 -587,000 -1,083,000 -407,000 -933,000 -780,000 -2,291,000 -906,000 -334,000 -1,024,000 -1,252,000 -72,000 -1,086,000 -676,000 -929,000 -538,000 -753,000 -768,000 -1,113,000 -1,051,000 -633,000 -420,000 -493,000 -389,000 -447,000 -428,000 -390,000 -702,000 -295,000 -446,000 -418,000 -343,000 -525,000 -305,000 -344,000 -571,000 -368,000    
          conversion of convertible note
        		                                                
          proceeds from issuance of common stock upon exercise of stock awards
        		    3,701,000 685,000 140,000 1,787,000 1,455,000 356,000 679,000 922,000 276,000 1,287,000 1,316,000 731,000 2,810,000 3,229,000 903,000 5,339,000 8,885,000 2,986,000 3,275,000 1,471,000 2,314,000 3,049,000 3,239,000 667,000 549,000 4,153,000 1,805,000 1,110,000 128,000 989,000 654,000 1,026,000 212,000 501,000 247,000 200,000 11,000 114,000 249,000 180,000 1,000   4,000 
          proceeds from issuance of common stock from employee stock purchase plan
        		                                                
          proceeds from sale of future royalties
        		                                                
          proceeds from non-controlling interest
        		                                                
          cash, cash equivalents, and restricted cash, beginning of year
        		                                                
          cash, cash equivalents, and restricted cash, end of year
        		                                                
          equity received in connection with license agreements
        		         0                                       
          non-cash interest expense
        		     782,000 833,000 1,067,000                                         
          deferred income
        		     -8,581,000 -6,902,000 -9,410,000                                         
          sale of equity securities
        		     2,403,000                                           
          purchase of patents, licenses, and other intangible assets
        		     -847,000                                           
          reduction of liability for sale of future royalties
        		     -2,124,000                                           
          accounts receivable and contract asset
        		       1,710,000  -34,981,000 -157,000 9,135,000  9,408,000 38,920,000 -26,820,000                                 
          repayment of liability for sale of future royalties
        		       -1,601,000                                         
          cash paid during the period for:
        		                                                
          interest
        		       11,000 1,000 7,000 7,000 7,000 0 4,000 5,000 4,000 1,000 4,000 5,000 4,000 0 4,000 5,000 6,000 0 4,000 3,000 4,000 7,000 3,000 3,000 3,000 5,000 3,000 2,000 3,000           3,000 2,000 
          supplemental disclosures of non-cash activities
        		                                                
          unrealized gain on marketable securities
        		       -1,445,000  1,151,000 1,766,000 3,327,000    -5,611,000   -113,000 23,000  -916,000                           
          rou assets obtained
        		       7,166,000                                         
          reconciliation of cash, cash equivalents, and restricted cash reported in the balance sheets
        		                                                
          cash and cash equivalents
        		       31,034,000                                         
          restricted cash
        		       382,000                                         
          total cash, cash equivalents, and restricted cash shown in the statement of cash flows
        		       31,416,000                                         
          consolidated net income
        		                                                
          adjustments to reconcile net income to net cash from operating activities:
        		                                                
          amortization of premium (accretion of discount) on marketable securities
        		                528,000 921,000 846,000 865,000                             
          equity received in connection with sale of financial assets
        		                0 0                               
          equity securities impairment
        		                                                
          accounts receivable and contract assets
        		                                                
          income tax
        		                                                
          proceeds from sale and maturities of marketable debt securities available-for-sale
        		                                                
          conversion (purchase) of convertible note
        		                                                
          exercise of stock options
        		                                                
          proceeds from issuance of common stock
        		                            0 0 0 260,245,000         0 0 0 122,906,000     
          supplemental disclosures of cash flow information
        		                                                
          cash paid for:
        		                                                
          taxes
        		                                                
          supplemental schedule of noncash activities
        		                                                
          net unrealized gain on marketable securities available-for-sale
        		                                       619,000         
          addition of right-of-use asset
        		                                                
          proceeds from maturities and sale of marketable securities
        		         216,510,000 185,018,000 154,562,000    20,000,000  122,130,000 97,542,000 124,210,000                             
          supplemental disclosures of non-cash investing activities
        		                                                
          net decrease in cash and cash equivalents
        		             3,244,000                     -2,341,000 -967,000             
          cash and cash equivalents, beginning of period
        		          0 53,942,000  0 0 143,480,000  0 0 163,544,000  0 0 50,312,000  0 0 26,246,000  0 0 16,528,000  0 0 14,528,000  0 0 12,590,000  0 0 54,649,000     
          cash and cash equivalents, end of period
        		          -37,684,000 72,394,000  3,244,000 -28,857,000 78,267,000  -74,642,000 -61,123,000 176,965,000  -51,440,000 35,726,000 73,808,000  18,632,000 10,699,000 21,858,000  -296,000 -216,280,000 251,572,000  2,414,000 -2,341,000 13,561,000  6,910,000 -273,000 8,150,000  46,567,000 -107,877,000 119,048,000     
          net income
        		           -60,763,000 -12,042,000 -32,759,000 -33,974,000 23,594,000 73,061,000 -40,191,000   -13,691,000 -12,550,000 -35,018,000 -8,074,000 -26,912,000 -10,225,000 -16,033,000 80,045,000     -11,843,000 -15,563,000   -9,065,000 -8,077,000       -1,349,000    
          amortization of premium on marketable securities
        		           -1,661,000  -59,000 425,000 543,000             -462,000 -338,000 -74,000 480,000 697,000 792,000 697,000 659,000 639,000 522,000 450,000 426,000 454,000 402,000 177,000 63,000     
          net increase in cash and cash equivalents
        		           18,452,000    -65,213,000 102,280,000 -74,642,000 -61,123,000 13,421,000 105,450,000 -51,440,000 35,726,000 23,496,000 -877,000 18,632,000 10,699,000 -4,388,000 -8,750,000 -296,000 -216,280,000 235,044,000 2,894,000    -259,000   -4,440,000 -45,148,000 46,567,000 -107,877,000 64,399,000     
          gain on sale of marketable securities available-for-sale
        		                                                
          cash redemption of equity received in connection with license agreement
        		                                                
          contract asset and deposits
        		                0 121,000 12,000,000 -62,000 -12,454,000                            
          proceeds from sale and maturities of marketable securities available-for-sale
        		                                       26,660,000         
          cash and cash equivalents, beginning of year
        		                                                
          cash and cash equivalents, end of year
        		                                                
          purchase of equity securities
        		                                                
          proceeds from maturities of marketable debt securities
        		                                                
          unrealized loss on marketable debt securities
        		             -931,000                                   
          proceeds from maturities and sale of marketable debt securities
        		                                                
          prepaid expenses and other current assets
        		                                          -392,000 -142,000     
          income tax receivable
        		                                                
          deferred rent
        		                        0 0 0 -1,513,000 -68,000 260,000 -36,000 242,000 230,000 371,000 18,000 -30,000 -27,000 -9,000 -27,000 -26,000 -23,000 -22,000 64,000 553,000     
          purchase of convertible note
        		                                                
          supplemental schedule of noncash investing activities
        		                                                
          gain on sale of marketable securities available for sale
        		                     0                           
          interest receivable
        		                 -314,000 185,000 311,000 55,000 221,000 699,000 215,000 -384,000 151,000 -185,000 31,000 89,000 -29,000 -286,000 -309,000 295,000 -444,000 335,000 -479,000 11,000 -701,000 119,000 41,000 -239,000 11,000 -524,000 -146,000     
          lease liabilities and right of use (rou) assets
        		                 469,000 -41,000 -42,000  -58,000                           
          unrealized loss on marketable securities
        		                                                
          change in fair value of equity security
        		                   -12,980,000 689,000 -2,772,000 -358,000 2,336,000                         
          loss on sale of marketable securities available-for-sale
        		                                                
          income tax payable
        		                                                
          proceeds from repayment of loan receivable
        		                                                
          common stock issuance costs
        		                            0 0 -1,000 -14,740,000         0 0 -166,000 -7,536,000     
          accretion of discount on marketable securities
        		                     -143,000 -265,000 -573,000                         
          unrealized gain on marketable securities, net of tax
        		                       -105,000  -193,000 1,284,000 1,316,000  -730,000 593,000 -393,000  143,000 -44,000 245,000             
          other assets
        		                                               50,000 
          proceeds from repayment of (investment in) loan receivable
        		                                                
          amortization of premium and accretion of discount on marketable securities
        		                         -1,457,000 -1,275,000 -601,000                     
          contract asset
        		                                                
          repayment of loan
        		                                                
          repayment (issuance) of loan
        		                                                
          proceeds from sale and maturities of marketable securities
        		                              65,506,000 47,020,000  23,700,000 36,955,000 16,911,000  68,545,000           
          loan receivable
        		                              0 86,000                 
          net unrealized loss on marketable securities available-for-sale
        		                                        510,000        
          gain on disposal of assets
        		                                                
          deferred tax liability
        		                                                
          payments on capital lease obligations
        		                                                
          net unrealized gain on marketable securities, net of tax
        		                                                
          gain on sale and maturities of marketable securities available-for-sale
        		                                                
          loss on exchange of notes for preferred stock
        		                                                
          accrued interest on convertible promissory notes
        		                                                
          proceeds from sale of series a-1 preferred stock
        		                                                
          preferred stock issuance cost
        		                                                
          supplemental schedule of noncash financing activities
        		                                                
          settlement of notes payable for preferred stock
        		                                                
          proceeds from sale of marketable securities available-for-sale
        		                                                
          net unrealized loss on marketable securities available for sale
        		                                          55,000 35,000     
          supplemental disclosures of non-cash investing and financing activities
        		                                                
          gain from non-monetary exchange
        		                                                
          proceeds from sale of series a-1preferred stock
        		                                                
          proceeds from sale of common stock
        		                                                
          payments of initial public offering costs
        		                                                
          capitalization of licensing rights acquired in non-monetary exchange
        		                                                
          equipment acquired under capital lease
        		                                                
          proceeds from the sale of series a-1 preferred
        		                                                
          preferred stock issuance costs
        		                                                
          net increase in cash
        		                                                
          cash, beginning of period
        		                                             0 0 77,975,000 
          cash, end of period
        		                                             -5,295,000 -6,318,000 72,536,000 
          money market funds