7Baggers

Verona Pharma plc
(NASDAQ:VRNA) 

VRNA stock logo

Verona Pharma plc, a clinical stage biopharmaceutical company, focuses on development and commercialization of therapies for the treatment of respiratory diseases with unmet medical needs. Its product candidate is ensifentrine, an inhaled and dual inhibitor of the phosphodiesterase (PDE) 3 and PDE4 ...

Founded: 2005
Full Time Employees: 33
Sector: Healthcare
Industry: Biotechnology

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At a glance:
Bull Thesis:
Bear Thesis:
Main Competitors:
Moat:
Income Statements:
Quarterly
Annual
    Unit: USD2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 
                       
      revenue:
                       
      product sales
    102,939,000 71,256,000 36,637,000 5,624,000                
      other revenue
    199,000 5,000,000                  
      total revenue
    103,138,000 76,256,000                  
      yoy
                       
      qoq
    35.25%                   
      operating expenses:
                       
      cost of sales
    4,756,000 3,407,000 2,039,000 543,000                
      research and development
    12,950,000 14,054,000 7,870,000 10,552,000 19,388,000 6,764,000 4,122,000 2,958,000 -2,474,000 12,610,000 6,838,000 9,838,000 14,982,000 17,625,000 22,709,000 22,560,000 20,563,000 13,574,000  
      selling, general and administrative
    72,127,000 69,112,000 45,085,000 35,196,000 49,035,000 20,434,000 14,972,000 13,353,000 12,439,000 9,589,000 8,323,000 5,290,000 5,526,000 7,440,000 5,757,000 10,883,000    
      total operating expenses
    89,833,000 86,573,000 54,994,000 46,291,000 68,423,000 27,198,000 19,094,000 16,311,000 9,965,000 22,199,000 15,161,000 15,128,000 20,508,000 25,065,000 28,466,000 33,443,000 28,548,000 22,856,000  
      operating income
    13,305,000 -10,317,000 -18,339,000 -40,667,000 -68,423,000 -27,198,000 -19,094,000 -16,311,000 -9,965,000 -22,199,000   -20,508,000 -25,065,000   -28,548,000 -22,856,000  
      yoy
    -119.45% -62.07% -3.95% 149.32% 586.63% 22.52%   -51.41% -11.43%   -28.16% 9.66%      
      qoq
    -228.96% -43.74% -54.90% -40.57% 151.57% 42.44% 17.06% 63.68% -55.11%    -18.18%    24.90%   
      operating margin %
    12.90% -13.53% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% NaN% NaN% -Infinity% -Infinity% NaN% NaN% -Infinity% -Infinity%  
      other income:
                       
      research and development tax credit
      556,000 1,612,000 847,000 585,000 1,034,000 -309,000 -1,934,000 2,313,000 796,000 2,127,000 5,409,000 1,302,000 4,975,000 4,749,000    
      loss on extinguishment of debt
     -407,000   -3,653,000               
      interest income
    4,302,000 3,891,000 3,994,000 4,750,000 3,140,000 3,378,000 3,292,000 3,390,000 3,402,000 2,677,000 1,862,000 779,000 165,000 15,000 3,000 4,000 3,000 4,000  
      interest expense
    -6,822,000 -10,195,000 -10,317,000 -9,882,000 -1,757,000 -1,586,000 -623,000 -401,000 -740,000 -293,000 -230,000 -116,000 -91,000 -84,000 -85,000 -86,000 -85,000 -84,000  
      foreign exchange gain
    1,097,000 470,000 -1,450,000 1,475,000 25,000  1,206,000 -1,012,000 740,000 932,000 -1,707,500 -3,245,000 -2,662,000  59,000 -86,000 40,000 163,000  
      total other income
    -1,423,000 -6,241,000 -7,217,000 -2,045,000 -1,398,000  4,909,000 1,668,000 1,468,000 5,629,000 4,626,000 -455,000 2,821,000 310,000 4,954,000 4,621,000 6,505,000 1,646,000  
      income before income taxes
    11,882,000 -16,558,000 -25,556,000 -42,712,000 -69,821,000 -25,040,000 -14,185,000 -14,643,000 -8,497,000 -16,570,000   -17,687,000 -24,755,000   -22,043,000 -21,210,000  
      income tax benefit
    39,000 239,000                  
      net income
    11,921,000 -16,319,000 -33,827,000 -42,962,000 -70,835,000 -25,794,000 -14,132,000 -14,687,000 -8,807,000 -16,743,000   -17,766,000 -24,837,000   -22,068,000 -21,290,000  
      yoy
    -116.83% -36.73% 139.36% 192.52% 704.30% 54.06%   -50.43% -32.59%   -19.49% 16.66%      
      qoq
    -173.05% -51.76% -21.26% -39.35% 174.62% 82.52% -3.78% 66.77% -47.40%    -28.47%    3.65%   
      net income margin %
    11.56% -21.40% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% NaN% NaN% -Infinity% -Infinity% NaN% NaN% -Infinity% -Infinity%  
      income per ordinary share - basic
    20                   
      income per ordinary share - diluted
    20                   
      income per ads - basic
    140                   
      income per ads - diluted
    130                   
      weighted-average ordinary shares outstanding - basic
    685,155,000                   
      weighted-average ordinary shares outstanding - diluted
    727,223,000                   
      weighted-average ads outstanding - basic
    85,644,000                   
      weighted-average ads outstanding - diluted
    90,903,000                   
      loss per ordinary share - basic and diluted
     -20 -55 -70 -110 -40 -15 -20 -10 -30   -40 -50   -50 -50  
      weighted-average shares outstanding - basic and diluted
     679,405,000 652,310,582,000 651,944,000 648,217,000 645,701,000 634,142,660,000 638,238,749,000 634,469,423,000 621,451,000   484,777,837,000    470,786,767,000 469,465,085,000  
      income tax expense
      -8,271,000 -250,000 -1,014,000 -754,000 53,000 -44,000 -310,000 -173,000 -56,250 -64,000 -79,000 -82,000 -58,000 -127,000 -25,000 -80,000  
      other income/
                       
      foreign exchange (loss)/gain
         -219,000        -923,000      
      total other income/(expense)
         2,158,000              
      revenue
                   40,000,000    
      gross profit
                       
      yoy
                       
      qoq
                       
      gross margin %
    0% 0% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN%  
      operating expenses
                       
      operating profit
              -15,175,250 -15,128,000   -11,211,750 6,557,000    
      other income
                       
      fair value movement on warrants
                  2,000 40,000 2,711,000 -507,000  
      profit before income taxes
              -14,506,250 -15,583,000   -8,018,750 11,178,000    
      net profit
              -14,562,500 -15,647,000   -8,076,750 11,051,000    
      profit per ordinary share - basic
              -30 -30   -17.5 20    
      profit per ordinary share - diluted
              -30 -30   -17.5 20    
      weighted-average shares outstanding - basic
               544,134,136,000    475,334,354,000    
      weighted-average shares outstanding - diluted
               544,134,136,000    515,819,439,000    
      other comprehensive profit:
                       
      foreign currency translation adjustments
                       
      total comprehensive profit attributable to shareholders of the company
                  -8,076,750 11,051,000    
      general and administrative
                    7,985,000 9,282,000  
      benefit from research and development tax credit
                    3,836,000 2,070,000  
      other comprehensive loss:
                       
      total comprehensive loss attributable to shareholders of the company
                    -22,068,000 -21,290,000  
      other comprehensive income:
                       
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2018-03-21 2017-12-31 2017-11-03 2017-09-30 2017-08-08 2017-06-30 
                                          
        assets
                                          
        current assets:
                                          
        cash and cash equivalents
      438,016,000 401,415,000 399,757,000 336,040,000 404,599,000 254,882,000 271,772,000 257,366,000 270,727,000 291,415,000 227,827,000 231,701,000 111,510,000 132,764,000 148,380,000 166,547 146,035,000 169,598,000 187,986,000 201,968 18,081 20,059 22,934 33,823 22,434 18,726 19,784 27,561 36,574 29,013 31,443 31,443 31,393,327 31,393,327 62,613,988 62,613,988 
        accounts receivable
      82,858,000 62,159,000 31,496,000 6,904,000             25,002,000                    
        prepaid expenses
      11,432,000 11,317,000 7,573,000 7,964,000 5,433,000 3,622,000 3,617,000 3,332,000 894,000 1,561,000 2,499,000 3,355,000 4,731,000 1,246,000 4,037,000 6,672 9,817,000 7,247,000 4,538,000                  
        tax incentive receivable
      4,061,000 5,935,000 5,762,000 5,587,000 3,684,000 11,461,000  9,510,000 10,150,000 11,842,000                           
        inventory
      8,612,000 7,244,000 6,249,000 4,315,000                                 
        other current assets
      3,872,000 12,955,000 2,735,000 3,443,000 2,576,000 1,875,000 3,365,000 6,319,000 6,060,000 2,073,000 3,388,000 3,077,000 2,206,000 2,525,000 2,063,000 667 2,320,000 1,484,000 1,720,000                  
        total current assets
      548,851,000 501,025,000 453,572,000 364,253,000 416,292,000 271,840,000 289,708,000 276,527,000 287,831,000 306,891,000 242,996,000 258,454,000 138,632,000 152,955,000 170,063,000 184,492 216,283,000 188,601,000  212,474 25,271 31,398 40,923 50,728 57,864 62,319 71,665 74,079 78,096 80,417 87,078 87,078     
        non-current assets:
                                          
        furniture and equipment
      991,000 1,048,000 1,105,000 40,000 44,000 22,000 24,000 10,000 11,000 12,000 73,000 81,000 91,000 71,000 80,000 88 89,000 98,000 107,000                  
        inventory, long-term
      5,910,000 6,508,000 1,972,000                                  
        goodwill
      545,000 545,000 545,000 545,000 545,000 545,000 545,000 545,000 545,000 545,000 545,000 544,000 545,000 545,000 545,000 545 545,000 545,000 545,000 545 441 441 441 441 441 441 441 441 441 441 441 441 441,000 441,000 441,000 441,000 
        equity interest
      15,000,000 15,000,000 15,000,000 15,000,000 15,000,000 15,000,000 15,000,000 15,000,000 15,000,000 15,000,000 15,000,000 15,000,000 15,000,000 15,000,000 15,000,000 15,000                     
        right-of-use assets
      1,574,000 1,810,000 2,048,000 1,980,000 2,242,000 2,505,000 2,847,000 388,000 542,000 698,000 854,000 793,000 588,000 744,000 899,000 1,435 1,585,000 906,000 1,050,000   1,210 971              
        total non-current assets
      24,020,000 24,911,000 20,670,000 17,565,000 17,831,000 18,072,000  15,943,000 16,098,000 16,255,000  16,418,000 16,224,000 16,360,000  17,068 2,219,000 1,549,000  33,353 27,004 4,465 4,212 3,823 2,826 2,882 2,596 2,590 2,554 2,544 2,426 2,426     
        total assets
      572,871,000 525,936,000 474,242,000 381,818,000 434,123,000 289,912,000 308,124,000 292,470,000 303,929,000 323,146,000 259,468,000 274,872,000 154,856,000 169,315,000 186,587,000 201,560 218,502,000 190,150,000 204,206,000 245,827 52,275 35,863 45,135 54,551 60,690 65,201 74,261 76,669 80,650 82,961 89,504 89,504 94,900,476 94,900,476 102,230,971 102,230,971 
        liabilities and shareholders’ equity
                                          
        current liabilities:
                                          
        accounts payable
      3,434,000 9,077,000 11,266,000 6,831,000 4,152,000 4,651,000 3,492,000 823,000 2,493,000 7,237,000 2,910,000 8,002,000 9,364,000 8,064,000 10,044,000 34,000 541,000 178,000                  
        accrued expenses
      43,328,000 32,335,000 16,757,000 18,143,000 19,630,000 8,269,000 3,585,000 7,397,000 7,467,000 17,703,000 13,752,000 22,978,000 28,603,000 28,877,000 22,256,000 26,457 17,188,000 8,514,000 10,863,000                  
        royalties payable
      3,088,000 4,487,000 1,100,000 169,000                                 
        revenue interest purchase security agreement
         102,019,000 96,338,000                                
        current operating lease liabilities
      1,014,000 1,078,000 1,120,000 952,000 1,031,000 1,118,000 1,180,000 376,000 545,000 650,000 675,000                          
        taxes payable
       8,889,000 8,889,000 1,011,000 1,011,000     424,000 283,000 285,000 311,000 235,000 147,000 397                     
        other current liabilities
      374,000 678,000 2,862,000 844,000 1,200,000 736,000 435,000 416,000 444,000 509,000 1,409,000 294,000 121,000 144,000 327,000 185 300,000 133,000 118,000                  
        total current liabilities
      51,238,000 56,544,000 42,681,000 27,950,000 48,346,000 14,774,000 8,692,000 9,012,000 10,949,000 26,523,000 19,029,000 32,128,000 38,863,000 37,903,000 33,422,000 27,740 58,364,000 12,698,000 14,203,000 16,859 8,460 8,025 9,616 12,460 9,728 5,973 10,225 10,390 12,778 16,281 8,596 8,596 8,827,222 8,827,222 8,215,766 8,215,766 
        non-current liabilities:
                                          
        term loan
      242,434,000 241,742,000 120,341,000 120,009,000 119,687,000 48,546,000 48,374,000 19,905,000 19,857,000 19,809,000 9,768,000 5,035,000 4,981,000 4,928,000 4,874,000 4,821 4,767,000 4,685,000 4,635,000                  
        non-current operating lease liabilities
      926,000 1,055,000 1,241,000 1,349,000 1,478,000 1,604,000 1,775,000 20,000 30,000 65,000 205,000                          
        total non-current liabilities
      243,360,000 242,797,000 227,002,000 223,377,000 217,503,000 50,150,000 50,149,000 19,925,000 19,887,000 19,874,000 9,973,000 5,259,000 5,113,000 5,105,000 5,160,000 5,618 5,741,000 5,038,000 5,149,000 31,253 24,622 2,014 1,654 1,808 1,139 1,113 1,102 1,080 1,061 1,030 1,027 1,027 852,070 852,070 835,685 835,685 
        total liabilities
      294,598,000 299,341,000 269,683,000 251,327,000 265,849,000 64,924,000 58,841,000 28,937,000 30,836,000 46,397,000 29,002,000 37,387,000 43,976,000 43,008,000 38,582,000 33,358 64,105,000 17,736,000 19,352,000                  
        commitments and contingencies
                                          
        shareholders' equity:
                                          
        ordinary £0.05 par value shares; 703,189,462 and 703,189,462 issued, and 687,930,486 and 677,008,254 outstanding, at june 30, 2025 and december 31, 2024, respectively
      45,021,000                                    
        additional paid-in capital
      805,918,000 766,369,000 728,199,000 621,628,000 616,618,000 602,497,000 601,063,000 601,180,000 596,059,000 590,915,000 529,187,000 525,858,000 390,543,000 388,204,000 385,070,000 382,005 379,282,000 375,261,000 366,411,000                  
        ordinary shares held in treasury
      -964,000 -1,402,000 -1,659,000 -828,000 -1,203,000 -1,282,000 -1,517,000 -746,000 -975,000 -1,208,000 -1,549,000 -449,000 -591,000 -739,000 -603,000 -770 -843,000 -1,670,000 -1,700,000                  
        accumulated other comprehensive loss
      -4,601,000 -4,601,000 -4,601,000 -4,601,000 -4,601,000 -4,601,000 -4,601,000 -4,601,000 -4,601,000 -4,601,000 -4,601,000 -4,601,000 -4,601,000 -4,601,000 -4,601,000 -4,601 -4,601,000 -4,601,000 -4,601,000                  
        accumulated deficit
      -567,101,000 -578,792,000 -562,401,000 -528,479,000 -485,311,000 -414,397,000 -388,433,000 -374,053,000 -359,143,000 -350,110,000 -333,097,000 -322,442,000 -306,653,000 -288,739,000 -263,716,000 -240,287 -251,265,000 -228,370,000 -207,050,000                  
        total shareholders' equity
      278,273,000 226,595,000 204,559,000 130,491,000 168,274,000 224,988,000 249,283,000 263,533,000 273,093,000 276,749,000 230,466,000 237,485,000 110,880,000 126,307,000 148,005,000 168,202 154,397,000 172,414,000 184,854,000                  
        total liabilities and shareholders' equity
      572,871,000 525,936,000 474,242,000 381,818,000 434,123,000 289,912,000 308,124,000 292,470,000 303,929,000 323,146,000 259,468,000 274,872,000 154,856,000 169,315,000 186,587,000 201,560 218,502,000 190,150,000 204,206,000                  
        ordinary £0.05 par value shares; 703,189,462 and 703,189,462 issued, and 681,056,022 and 677,008,254 outstanding, at march 31, 2025 and december 31, 2024, respectively
       45,021,000                                   
        revenue interest purchase and sale agreement
        687,000                                  
        ordinary £0.05 par value shares: 703,189,462 and 667,659,630 issued, and 677,008,254 and 643,536,094 outstanding, at december 31, 2024 and 2023, respectively
        45,021,000                                  
        ordinary £0.05 par value shares; 667,659,630 and 667,659,630 issued, and 654,649,358 and 643,536,094 outstanding, at september 30, 2024 and december 31, 2023, respectively
         42,771,000                                 
        license agreement obligations
          21,322,000                                
        ordinary £0.05 par value shares; 667,659,630 and 667,659,630 issued, and 648,654,174 and 643,536,094 outstanding, at june 30, 2024 and december 31, 2023, respectively
          42,771,000                                
        ordinary £0.05 par value shares; 667,659,630 and 667,659,630 issued, and 647,372,062 and 643,536,094 outstanding, at march 31, 2024 and december 31, 2023, respectively
           42,771,000                               
        tax incentive receivables
            10,954,000    9,282,000    15,583,000                      
        total non-current assets:
            18,416,000    16,472,000    16,524,000    1,702,000                  
        shareholders' equity
                                          
        ordinary £0.05 par value shares: 667,659,630 and 631,338,246 issued, and 643,536,094 and 606,301,054 outstanding, at december 31, 2023 and 2022, respectively
            42,771,000                              
        ordinary £0.05 par value shares; 651,659,630 and 631,338,246 issued, and 639,520,054 and 606,301,054 outstanding, at september 30, 2023 and december 31, 2022, respectively
             41,753,000                             
        ordinary £0.05 par value shares; 651,659,630 and 631,338,246 issued, and 635,787,302 and 606,301,054 outstanding, at june 30, 2023 and december 31, 2022, respectively
              41,753,000                            
        ordinary £0.05 par value shares; 651,659,630 and 631,338,246 issued, and 631,987,078 and 606,301,054 outstanding, at march 31, 2023 and december 31, 2022, respectively
               41,753,000                           
        ordinary £0.05 par value shares: 631,338,246 and 489,177,550 issued, and 606,301,054 and 480,082,966 outstanding, at december 31, 2022 and 2021, respectively
                40,526,000                          
        tax and tax incentive receivable
                 20,321,000 20,185,000 16,420,000  10,606                     
        operating lease liability
                 569,000 464,000 583,000 648,000 690 749,000 757,000 798,000                  
        ordinary £0.05 par value shares; 608,138,246 and 489,177,550 issued, and 602,215,606 and 480,082,966 outstanding, at september 30, 2022 and december 31, 2021, respectively
                 39,119,000                         
        ordinary £0.05 par value shares; 494,058,246 and 489,177,550 issued, and 485,298,326 and 480,082,966 outstanding, at june 30, 2022 and december 31, 2021, respectively
                  32,182,000                        
        ordinary £0.05 par value shares; 494,058,246 and 489,177,550 issued, and 482,944,390 and 480,082,966 outstanding, at march 31, 2022 and december 31, 2021, respectively
                   32,182,000                       
        warrants
                     42,000 2,753,000 2,246,000                  
        ordinary £0.05 par value shares: 489,177,550 and 488,304,446 issued, and 480,082,966 and 463,304,446 outstanding, at december 31, 2021 and 2020, respectively
                    31,855,000                      
        ordinary £0.05 par value shares; 489,177,550 and 488,304,446 issued, and 477,649,646 and 463,304,446 outstanding, at september 30, 2021 and december 31, 2020, respectively
                     31,855                     
        tax and tax incentive receivables
                      14,108,000 10,272,000 8,260,000                  
        contract asset
                      4,001,000                    
        equity interest receivable
                      15,000,000                    
        deferred revenue
                      40,051,000                    
        ordinary £0.05 par value shares; 488,739,150 and 488,304,446 issued, and 471,839,302 and 463,304,446 outstanding, at june 30, 2021 and december 31, 2020, respectively
                      31,824,000                    
        ordinary £0.05 par value shares; 488,304,446 and 488,304,446 issued, and 463,745,750 and 463,304,446 outstanding, at march 31, 2021 and december 31, 2020, respectively
                       31,794,000                   
        short-term investments
                                          
        total current assets:
                        202,504,000                  
        ordinary £0.05 par value shares; 488,304,446 and 105,326,638 issued, and 463,304,446 and 105,326,638 outstanding, at december 31, 2020 and 2019, respectively
                        31,794,000                  
        intangible assets
                         31,507 25,430 2,772 2,757 2,241 2,174 2,171 2,134 2,138 2,100 2,088 1,969 1,969 2,003,841 2,003,841 1,961,631 1,961,631 
        property, plant and equipment
                         107 37 42 43 1,141 211 270 21 11 13 15 16 16 12,819 12,819 12,703 12,703 
        right-of-use asset
                         1,194 1,096                
        prepayments and other receivables
                         4,668 4,420 1,972 2,770 3,486 3,427 2,476 2,463 1,963 2,227 1,870 1,810 1,810 3,916,024 3,916,024 2,434,900 2,434,900 
        current tax receivable
                         5,838 2,770 8,667 7,396 6,177 7,912 5,808 4,499 3,226 7,013 5,929 5,006 5,006 3,068,523 3,068,523 2,809,932 2,809,932 
        short term investments
                           700 7,823 7,242 24,091 35,309 44,919 41,329 32,282 43,605 48,819 48,819 54,064,942 54,064,942 31,956,817 31,956,817 
        equity and liabilities
                                          
        capital and reserves attributable to equity holders:
                                          
        share capital
                         30,054 5,324 5,311 5,266 5,266 5,266 5,266 5,266 5,266 5,251 5,251 5,251 5,251 5,250,870 5,250,870 5,244,203 5,244,203 
        share premium
                         330,068 118,862 118,862 118,862 118,862 118,862 118,862 118,862 118,862 118,862 118,862 118,862 118,862 118,861,212 118,861,212 118,721,212 118,721,212 
        share-based payment reserve
                         23,430 12,572 11,811 10,364 9,789 9,209 8,543 7,923 7,253 6,549 6,041 5,022 5,022 4,092,921 4,092,921 3,070,095 3,070,095 
        cumulative translation adjustment
                         -5,796                 
        accumulated loss
                         -180,041 -117,565 -110,160 -100,627 -93,634 -83,514 -74,556 -69,117 -66,182 -63,851 -64,504  -49,254     
        total equity
                         197,715 19,193 25,824 33,865 40,283 49,823 58,115 62,934 65,199 66,811 65,650 79,881 79,881 85,221,184 85,221,184 93,179,520 93,179,520 
        derivative financial instrument
                         1,857 711 783 895 415 769 882 2,492 4,658 7,249 10,250 1,273 1,273 3,997,333 3,997,333 2,809,670 2,809,670 
        lease liabilities
                         808 638 623   163            
        trade and other payables
                         14,194 7,111 6,619 8,261 11,605 8,796 4,850 7,733 5,732 5,529 5,766 7,154 7,154 4,751,798 4,751,798 5,308,334 5,308,334 
        assumed contingent liability
                         30,552   1,103              
        non-current lease liability
                         667 677 809 491 640             
        deferred income
                         34 38 49 60 72 83 95 106 118 129 140 152 152     
        total equity and liabilities
                         245,827 52,275 35,863 45,135 54,551 60,690 65,201 74,261 76,669 80,650 82,961 89,504 89,504 94,900,476 94,900,476 102,230,971 102,230,971 
        assumed contingent obligation
                          23,907 1,156  1,096 1,056 1,018 996 962 932 890 875 875 852,070 852,070 835,685 835,685 
        lease liability
                            460 440             
        finance lease liabilities
                               241           
        tax payable—u.s. operations
                                   265 169 169     
        tax payable — u.s. operations
                                          
        non-current assets: - sum
                                      2,457,660  2,415,334  
        current assets: - sum
                                      92,442,816  99,815,637  
        tax payable — us operations
                                      78,091 78,091 97,762 97,762 
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 
                                        
          cash flows from operating activities:
                                        
          net loss:
        11,921,000 -16,319,000 -33,827,000    -14,132,000 -14,687,000 -8,807,000 -16,743,000 -10,451,000 -15,647,000 -17,766,000 -24,837,000 -23,262,000 11,051,000 -22,068,000 -21,290,000               
          adjustments to reconcile net income to net cash from operating activities:
                                        
          foreign exchange loss
        -1,097,000 -470,000     -1,206,000 1,012,000 -740,000 -932,000 -3,288,000 3,849,000 2,137,000 1,119,000                   
          amortization of debt issuance costs
        692,000 654,000                               
          accretion of ripsa
        1,654,000 3,893,000                              
          accretion of redemption premium on debt
          30,000 90,000 22,000 33,000 33,000 18,000 14,000 31,000 32,000 31,000 31,000 31,000 32,000 31,000               
          loss on extinguishment of debt
        407,000                             
          share-based compensation
        34,814,000 37,477,000 13,738,000 7,654,000 15,594,000 4,258,000 4,569,000 5,079,000 5,074,000 4,290,000 4,504,000 2,816,000 3,053,000 3,748,000 4,187,000 4,938,000 7,450,000 8,850,000               
          depreciation
        293,000 295,000 259,000 266,000 270,000 263,000  155,000 157,000 157,000                       
          changes in operating assets and liabilities:
                                        
          accounts receivable
        -20,699,000 -30,663,000 -24,592,000                              
          prepaid expenses
        -115,000 -3,744,000 391,000 -2,531,000 -1,811,000 -5,000 -285,000 -2,438,000 667,000 938,000 856,000 1,376,000 -3,485,000 2,791,000 2,635,000 3,145,000 -2,570,000 -2,709,000               
          tax incentive receivable
          -556,000 -1,611,000 7,786,000 -585,000  310,000 1,933,000 -2,313,000  -2,652,000 -4,883,000 -1,578,000                   
          inventory
        -770,000 -5,531,000 -3,906,000                              
          other current assets
        9,408,000 -9,980,000 708,000 -867,000 -907,000 942,000 3,037,000 -244,000 -3,378,000 1,362,000 -311,000 -871,000 319,000 -462,000 -1,396,000 1,653,000 -836,000 236,000               
          accounts payable
        -5,643,000 -2,189,000 4,435,000 2,679,000 -499,000 1,255,000 2,573,000 -1,670,000 -4,744,000 4,327,000 -5,104,000 -1,362,000 1,300,000 -1,980,000 10,035,000 -25,000 -507,000 363,000               
          accrued expenses
        10,993,000 16,113,000 -1,921,000 3,125,000 6,855,000 4,762,000 -3,996,000 -70,000 -10,236,000 3,951,000 -9,226,000 -5,625,000 -274,000 6,621,000 -4,206,000 9,270,000 8,674,000 -2,349,000               
          royalties payable
        -1,399,000 3,387,000 931,000                              
          operating lease liabilities
        -193,000 -228,000 -262,000 -208,000 -213,000 -152,000                           
          income taxes
        -9,214,000 -240,000 7,878,000 1,011,000 754,000 -83,000 -15,000                         
          other current liabilities
        -304,000 -2,184,000 2,018,000 -356,000 464,000 301,000 19,000 -28,000 -65,000 -886,000 1,319,000 -10,000 -48,000 -65,000 -79,000                  
          net cash from operating activities
        30,561,000 -11,561,000 -28,836,000 -62,655,000 -17,102,000 -13,610,000 -10,402,000 -12,727,000 -21,311,000 -5,782,000 -7,738,000 -18,095,000 -19,517,000 -14,512,000 -17,323,000 22,825,000 -20,205,000 -18,551,000 -45,050,295 -12,993 -2,571 -10,141 -9,281 -6,458 -8,218 -9,863 -5,055 -711 -6,109 -6,236   
          capital expenditures
        -535,000 -535,000 -29,000 -16,000  -1,000    
          free cash flows
        30,561,000 -12,096,000 -29,371,000 -62,655,000 -17,131,000 -13,626,000 -10,402,000 -12,727,000 -21,311,000  -7,738,000 -18,095,000 -19,517,000 -14,512,000 -17,324,000 22,825,000 -20,205,000  -45,050,295 -12,993 -2,571 -10,141 -9,281 -6,458 -8,218 -9,863 -5,055 -711 -6,109 -6,236   
          cash flows from investing activities:
                                        
          purchases of furniture and equipment
        -535,000 -535,000 -29,000 -16,000       -1,000                  
          net cash from investing activities
        -535,000 -535,000 -29,000 -16,000       -1,000                  
          cash flows from financing activities:
                                        
          proceeds from term loans
        122,500,000                             
          proceeds from ripsa
                                      
          payment of debt issuance costs
          -4,612,000 -1,939,000 -364,000                           
          repurchase of ripsa
        -109,921,000                               
          repayment of 2023 term loans
                                       
          payments of withholding taxes from share-based awards
        -4,287,000 -4,263,000 -6,143,000 -1,473,000 -3,575,000     -2,341,000 -900,000 -689,000 -793,000 -901,000 -2,167,000                 
          proceeds from exercise of share options
        4,943,000 5,165,000 924,000 3,668,000 816,000 -3,000 48,000 77,000 1,827,000 1,001,000                      
          net cash from financing activities
        4,943,000 13,457,000 94,157,000 -7,087,000   24,012,000 48,000 124,000 68,685,000 2,614,000 139,619,000 -689,000 -726,000 -901,000 -1,817,000     -131 -132  -128 -84 -84       
          effect of exchange rate changes on cash and cash equivalents
        1,097,000 297,000 -1,069,000 1,183,000 16,000 -141,000 796,000 -682,000 499,000 685,000 1,250,000 -1,333,000 -1,019,000 -378,000 58,000 -485,000 41,000 163,000               
          net change in cash and cash equivalents
        36,601,000 1,658,000 63,717,000 -68,559,000 149,717,000 -16,890,000 14,406,000 -13,361,000 -20,688,000 63,588,000 -3,874,000 120,191,000 -21,254,000 -15,616,000 -18,167,000                  
          cash and cash equivalents at beginning of the period
        399,757,000  271,772,000  227,827,000  148,380,000  187,986,000               
          cash and cash equivalents at end of the period
        36,601,000 401,415,000  -68,559,000 149,717,000 254,882,000  -13,361,000 -20,688,000 291,415,000  120,191,000 -21,254,000 132,764,000  20,512,000 -23,563,000 169,598,000               
          supplemental disclosure of cash flow information:
                                        
          income taxes paid
          393,000    30,000   30,000 89,000 1,000                   
          interest paid
        6,246,000 10,151,000 3,878,000 4,431,000 1,088,000 933,000 778,000 543,000 441,000 244,000 158,000 75,000 62,000 53,000 53,000 53,000 54,000 55,000               
          operating activities:
                                        
          adjustments to reconcile net loss to net cash from operating activities:
                                        
          proceeds from issuance of ordinary shares
              47,000 56,862,000 67,000                      
          payment of offering costs in connection with the issuance of ordinary shares
                  49,000                      
          proceeds from 2023 term loan, net of repayment of oxford term loan and debt issuance costs incurred
                                        
          repayment of term loans
                                        
          svb term loan repayment costs
                                        
          cash and cash equivalents at beginning of the year
                                        
          cash and cash equivalents at end of the year
                                        
          foreign exchange gain
                        -31,000 -155,000               
          amortization of debt issue costs
                  13,000 23,000 21,000 23,000 22,000 22,000 51,000 19,000               
          net income:
            -70,835,000 -25,794,000                           
          foreign exchange loss/
            -25,000 219,000                           
          other non-cash items
            203,000 82,000  15,000 15,000 73,000                       
          license agreement obligations
                                        
          proceeds from oxford term loan
                                        
          net cash (used in)/provided by financing activities
             -3,123,000                           
          depreciation and amortization
                  151,000 157,000 165,000 163,000 162,000 162,000 152,000 153,000               
          tax incentive receivables
                                        
          repayment of svb term loan
                                        
          right-of-use asset
                                        
          lease liabilities
               -179,000 -140,000 -165,000  197,000 -164,000 -174,000 -550,000 -216,000 603,000 -210,000               
          proceeds from draw under the oxford term loan
               9,996,000                       
          taxes payable
                 141,000 -2,000 -26,000 76,000 88,000 -304,000                  
          fair value movement on warrants
                      -2,000 -40,000 -2,711,000 507,000               
          equity interest recognized as revenue
                                        
          right-of-use assets
                                        
          proceeds from issuance of oxford term loan
                                        
          oxford term loan issuance costs
                                        
          equity interest receivable
                                        
          proceeds from at-the-market sales agreement
                   67,000  350,000                 
          deferred revenue
                                        
          impairment of right-of-use asset
                                        
          sale of short-term investments
                                        
          proceeds from issuance of term loan
                                        
          term loan issuance costs
                                        
          equity interest
                                        
          tax and tax incentive receivables
                        -3,836,000 -2,012,000               
          non-current assets
                                        
          other liabilities
                        167,000 15,000               
          net decrease in cash and cash equivalents
                             -3,076    -913    -1,784   
          net increase in cash and cash equivalents
                         -18,388,000 157,386,169 176,926    11,059         
          cash flows from investing activities
                                        
          purchases of short-term investments
                                        
          cash flows from financing activities
                                        
          proceeds from the issuance of term loan
                                        
          cash from operating activities:
                                        
          loss before taxation
                           -27,504 -8,772 -10,834  -12,766 -11,071 -6,719 -4,215 -3,459 -416 -16,043   
          finance income
                           -772 -141 -391 960 -1,109 -342 -1,860 -942 -740 -941 -160   
          finance expense
                           1,735 395 52 355 -68 -633 820 -2,138 -2,564 -4,297 10,324 -2,148,864 1,173,222 
          share-based payment charge
                           7,095 761 1,447 575 580 666 620 670 704 508 1,019 -1,988,212 1,022,826 
          increase in prepayments and other receivables
                              752    -417 201     
          increase in trade and other payables
                           4,077   -3,403 3,689   1,965 213   -2,792,783  
          depreciation of property, plant and equipment and right of use asset
                           221             
          impairment of right of use asset
                           57 232           
          unrealized foreign exchange losses
                           -19 -233           
          amortization of intangible assets
                           59 31 30 29 27 26 24 24 23 22 21 -50,189 18,153 
          cash from operating activities
                           -14,709   -9,281 -10,819   -5,051 -5,620 -5,794 -6,236   
          cash inflow from taxation
                           1,716      -4    -815,551  
          cash flow from investing activities:
                                        
          interest received
                           50 43 98 60 531 171 125 202 301 315 65 -87,228 20,329 
          purchase of plant and equipment
                             -4 -17 -19 -2 -12 -1   
          payment for patents and computer software
                           -123 -60 -45 -60 -94 -29 -61 -20 -61 -34 -140   
          transfer to short term investments
                                   -29,793 -11,065 -3,858   
          maturity of short term investments
                           1,944 700 7,148 24,448 11,714 8,972 11,512 20,906 23,562 8,386   
          net cash generated in investing activities
                           1,802 683 7,197  17,645 11,837 9,034       
          cash flow from financing activities:
                                        
          proceeds of private placement
                                        
          transaction costs of private placement
                                        
          payment of lease liabilities
                                        
          net cash generated from / (used) in financing activities
                                        
          cash and cash equivalents at the beginning of the period
                           7,494 22,934  19,784  31,443  
          effect of exchange rates on cash and cash equivalents
                           -533 41 201 -761 330 173 -145 580 345 892 -646   
          cash and cash equivalents at the end of the period
                           183,887 -1,978 20,059  11,389 3,708 18,726  -9,013 7,561 29,013 -31,361,884 -31,220,661 
          decrease in prepayments and other receivables
                            -2,463 753   -19 84    35   
          repayment of lease liabilities
                                        
          decrease in trade and other payables
                             -1,553    -2,899    -1,434   
          depreciation of property, plant and equipment and right of use assets
                             122           
          repayment of finance lease liabilities
                             -132    -84       
          income before taxation
                                        
          depreciation of property, plant, equipment and right of use asset
                                        
          unrealised fx gains/ losses
                                        
          purchase of short term investments
                                        
          net cash generated from / (used in) investing activities
                                        
          cash flow used in financing activities:
                                        
          gross proceeds from the april 2017 global offering
                                        
          transaction costs on april 2017 global offering
                                        
          net cash (used in) / generated from financing activities
                                        
          net increase / (decrease) in cash and cash equivalents
                                        
          cash and cash equivalents at the beginning of the year
                                        
          cash and cash equivalents at the end of the year
                                        
          depreciation of property, plant and equipment
                               117 79 78   
          unrealized foreign exchange gains
                               12 14 -11       
          cash outflow from taxation
                                        
          loss on disposal of property plant and equipment
                                        
          net cash generated from investing activities
                                        
          gross proceeds from issue of shares and warrants
                                        
          transaction costs on issue of shares and warrants
                                        
          net cash generated from financing activities
                                      -63,182,511  
          net cash generated from / (used in) in investing activities
                                        
          net cash generated in financing activities
                                        
          net cash generated / (used) in investing activities
                                        
          £'000s
                                        
          net cash (used) / generated in investing activities
                                     4,452   
          cash used in operating activities:
                                        
          loss on disposal of property, plant and equipment
                                        
          decrease / (increase) in prepayments and other receivables
                                        
          loss on disposal of intangible assets
                                        
          net (decrease) / increase in cash and cash equivalents
                                        
          depreciation of plant and equipment
                                       1,621 
          payments for patents
                                        
          transaction costs on global offering
                                        
          (decrease)/increase in trade and other payables
                                        
          short term investments
                                        
          gross proceeds from issue of shares
                                        
          net cash (used) / generated from financing activities
                                        
          decrease/(increase) in prepayments and other receivables