7Baggers

Verrica Pharmaceuticals Inc
(NASDAQ:VRCA) 

VRCA stock logo

Verrica Pharmaceuticals Inc., a dermatology therapeutics company, develops and commercializes treatments for people with skin diseases in the United States. The company's lead product candidate includes VP-102 for the treatment of molluscum contagiosum; which has completed phase II clinical trial fo...

Founded: 2013
Full Time Employees: 17
Sector: Healthcare
Industry: Biotechnology

Share this website to your friends
• Market Cap:
• Exchange:
• Shs Outstanding:
• Employees:
• Beta:
• Return on Equity (ROE) ttm:
• Return on Assets (ROA) ttm:
• EPS ttm:
• Book value per Share:
• Cash per Share:
• Current ast per Share:
• P/E ttm:
• P/E forward:
• P/E ttm high:
• P/E ttm low:
• P/S ttm:
• P/B ttm:
• P/FCF ttm:
• PEG ratio:
• Cash Ratio ttm:
• Quick Ratio ttm:
• Current Ratio ttm:
• Gross Mgn ttm:
• EBITDA Mgn ttm:
• Operating Mgn ttm:
• Net Income Mgn ttm:
• Trailing Div yield:
• Forward Div yield:
• Payout Ratio ttm:
• Ex-Dividend date:
• Target Price High:
• Target Price Low:
• Target Price Mean:
• Number of Analysts:
• Debt Ratio ttm:
• Debt to Equity ttm:
• Total Net Debt:
At a glance:
Bull Thesis:
Bear Thesis:
Main Competitors:
Moat:
Income Statements:
Quarterly
Annual
    Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 
                                    
      revenue:
                                    
      product revenue
    4,290,000 3,722,000 3,607,000 4,534,000 3,422,000 315,000 -1,865,000 4,892,000 3,232,000 1,866,000 2,792,000                      
      license and collaboration revenue
    733,000 1,370,000 10,737,000 8,168,000                             
      total revenue
    5,023,000 5,092,000 14,344,000 12,702,000 3,439,000 344,000 -1,781,000 5,177,000 3,826,000 1,988,000 2,917,000                      
      yoy
    46.06% 1380.23% -905.39% 145.35% -10.12% -82.70% -161.06%                          
      qoq
    -1.36% -64.50% 12.93% 269.35% 899.71% -119.31% -134.40% 35.31% 92.45% -31.85%                       
      operating expenses:
                                    
      cost of product revenue
    544,000 675,000 754,000 340,000 423,000 596,000 351,000 360,000 546,000 144,000 145,000                      
      cost of license and collaboration revenue
    345,000                                
      selling, general and administrative
    9,989,000 8,117,000 9,403,000 8,852,000 8,848,000 9,879,000 16,083,000 16,522,000 16,339,000 16,995,000 20,054,000                      
      research and development
    3,860,000 2,520,000 2,205,000 1,846,000 2,284,000 1,167,000 2,405,000 3,319,000 4,948,000 5,320,000 6,510,000 5,725,000 2,739,000 2,365,000 2,946,000 4,162,000 2,723,000 3,357,000 3,763,000 3,447,000 5,362,000 2,272,000 4,988,000 3,521,000 4,892,000 3,972,000 3,049,000 3,928,000 4,487,000 4,804,000 3,484,000 3,609,000 
      total operating expenses
    14,738,000 12,284,000 12,717,000 11,192,000 11,569,000 11,754,000 18,923,000 20,383,000 22,425,000 25,124,000 26,834,000 11,798,000 7,126,000 6,012,250 6,871,000 9,335,000 7,841,000 8,470,000 11,768,000 10,731,000 11,940,000 12,033,000 9,637,000 8,631,000 9,880,000 7,990,000 6,543,000 7,521,000 8,026,000 6,686,000 7,165,000 6,112,000 
      income from operations
    -9,715,000 -7,192,000 1,627,000 1,510,000 -8,130,000 -11,410,000 -20,704,000 -15,206,000 -18,599,000 -23,136,000 -23,917,000 -11,616,000 -7,089,000 -6,211,000 1,448,000 -9,121,000 -7,410,000 -8,470,000 -11,768,000 -10,731,000 60,000 -12,033,000 -9,637,000 -8,631,000 -9,880,000 -7,990,000 -6,543,000 -7,521,000 -8,026,000 -6,686,000 -7,165,000 -6,112,000 
      yoy
    19.50% -36.97% -107.86% -109.93% -56.29% -50.68% -13.43% 30.91% 162.36% 272.50% -1751.73% 27.35% -4.33% -26.67% -112.30% -15.00% -12450.00% -29.61% 22.11% 24.33% -100.61% 50.60% 47.29% 14.76% 23.10% 19.50% -8.68% 23.05%     
      qoq
    35.08% -542.04% 7.75% -118.57% -28.75% -44.89% 36.16% -18.24% -19.61% -3.27% 105.90% 63.86% 14.14% -528.94% -115.88% 23.09% -12.51% -28.03% 9.66% -17985.00% -100.50% 24.86% 11.66% -12.64% 23.65% 22.12% -13.00% -6.29% 20.04% -6.69% 17.23%  
      operating margin %
    -193.41% -141.24% 11.34% 11.89% -236.41% -3316.86% 1162.49% -293.72% -486.12% -1163.78% -819.92% -Infinity% -Infinity% -Infinity% Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% 
      other income:
                                    
      interest income
    201,000 205,000 159,000 228,000 337,000 205,000 221,000 393,000 598,000 792,000 822,000 626,000 500,000 286,000 148,000 20,000 22,000 27,000 31,000 33,000 32,000 48,000 69,000 126,000 278,000 354,000 453,000 523,000 547,000 610,000 427,000 153,000 
      interest expense
    -160,000 -1,314,000 -2,094,000 -2,131,000 -2,203,000 -2,349,000 -2,376,000 -2,368,000 -2,319,000 -2,305,000 -1,657,000    -81,000 -1,066,000 -1,082,000 -1,097,000 -1,092,000 -1,077,000 -1,028,000 -991,000 -918,000 -904,000 -220,000        
      change in fair value of derivative liability
     1,762,000 34,000 598,000 254,000                            
      other expense
    -8,000 -2,000  -1,000   -1,000 -5,000 -11,000       -1,000          -1,000  -3,000   -1,000  
      total other income
    33,000     -1,467,000 -2,156,000 -1,980,000 -1,732,000 60,500 -885,000 626,000 500,000        -996,000 -944,000 -849,000 -778,000 58,000 353,000 453,000 520,000 547,000 610,000 426,000 153,000 
      net income
    -9,682,000 -8,074,000 -274,000 204,000 -9,742,000 -16,202,000 -22,860,000 -17,186,000 -20,331,000 -24,614,000 -24,802,000 -10,990,000 -6,589,000 -5,932,000 83,000 -10,168,000 -8,470,000 -9,540,000 -12,829,000 -11,775,000 -936,000 -12,977,000 -10,486,000 -9,409,000 -9,822,000 -7,637,000 -6,090,000 -7,001,000 -7,479,000 -6,076,000 -6,739,000 -5,959,000 
      yoy
    -0.62% -50.17% -98.80% -101.19% -52.08% -34.18% -7.83% 56.38% 208.56% 314.94% -29981.93% 8.08% -22.21% -37.82% -100.65% -13.65% 804.91% -26.49% 22.34% 25.15% -90.47% 69.92% 72.18% 34.40% 31.33% 25.69% -9.63% 17.49%     
      qoq
    19.92% 2846.72% -234.31% -102.09% -39.87% -29.13% 33.02% -15.47% -17.40% -0.76% 125.68% 66.79% 11.08% -7246.99% -100.82% 20.05% -11.22% -25.64% 8.95% 1158.01% -92.79% 23.76% 11.45% -4.20% 28.61% 25.40% -13.01% -6.39% 23.09% -9.84% 13.09%  
      net income margin %
    -192.75% -158.56% -1.91% 1.61% -283.28% -4709.88% 1283.55% -331.97% -531.39% -1238.13% -850.26% -Infinity% -Infinity% -Infinity% Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% 
      net income per share
    -0.45 -0.65 -0.03 0.02 -0.1 -0.18 -0.49 -0.37 -0.44   -0.24 -0.15   -0.37 -0.31 -0.35 -0.47 -0.43 -0.04 -0.52 -0.42 -0.38 -0.39 -0.3 -0.24 -0.28 -0.3 -0.11 -0.27 -1.04 
      weighted-average common shares outstanding, basic and diluted
    21,305,025 10,652,367 9,490,083  94,837,343 51,808,228 46,805,427 46,502,274 46,483,669 45,342,451  45,916,867 43,023,379 34,163,437  27,519,053 27,519,053 27,044,462 27,516,477 27,513,665 25,602,404 24,995,556 24,988,939 24,965,634 24,964,167 24,897,889 24,893,036 24,875,573 24,857,771 14,662,751 24,847,512 5,751,326 
      cost of collaboration revenue
     130,750 355,000 154,000 14,000 29,000 84,000 182,000 592,000 128,000 125,000 136,000 68,000                    
      total other expense
     -882,000 -1,901,000 -1,306,000 -1,612,000         279,000 -1,365,000 -1,047,000 -1,060,000 -1,070,000 -1,061,000 -1,044,000             
      weighted-average common shares outstanding, basic
       9,488,055                             
      weighted-average common shares outstanding, diluted
       9,490,600                             
      collaboration revenue
        17,000 29,000 84,000 285,000 594,000 122,000 125,000 182,000 37,000                    
      loss on extinguishment of debt
                  -1,437,000                  
      other income
             -12,250 -50,000   -12,750 5,000                  
      net income per share
    -0.45 -0.65 -0.03 0.02 -0.1 -0.18 -0.49 -0.37 -0.44   -0.24 -0.15   -0.37 -0.31 -0.35 -0.47 -0.43 -0.04 -0.52 -0.42 -0.38 -0.39 -0.3 -0.24 -0.28 -0.3 -0.11 -0.27 -1.04 
      basic
             -0.235 -0.54   -0.145                   
      diluted
             -0.235 -0.54   -0.145                   
      weighted-average common shares outstanding
                                    
      basic
              46,073,932    40,304,923                  
      diluted
              46,073,932    44,656,172                  
      other comprehensive gain:
                                    
      unrealized gain on marketable securities
                  35  -33   -4 -5 -26 12  -7 -11 27 28    
      comprehensive income
             -10,595.25 -24,802   -4,638.75 118                  
      general and administrative
               5,937,000 4,319,000 3,189,000 3,925,000 5,173,000 5,118,000 5,113,000 8,005,000 7,284,000 6,578,000 9,761,000 4,649,000 5,110,000 4,988,000 4,018,000 3,494,000 3,593,000 3,539,000 1,882,000 3,681,000 2,503,000 
      other comprehensive loss:
                                    
      unrealized loss on marketable securities
                   -2  -27 -1           -10 -7  
      comprehensive loss
               -10,990 -6,589   -10,170 -8,503 -9,567 -12,830 -11,779 -934 -12,982 -10,512 -9,397 -9,822 -7,644 -6,101 -6,974 -7,451 -6,086 -6,746  
      license revenue
                 2,241,000 8,319,000 214,000 431,000    12,000,000            
      interest expense - related party
                                    
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2026-03-31 2025-09-30 2025-06-30 2025-03-31 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 
                                  
        assets
                                  
        current assets:
                                  
        cash
      20,600,000                            
        accounts receivable
      7,724,000 7,047,000 9,193,000 5,607,000 7,002,000 4,248,000 3,946,000                      
        collaboration receivable, billed and unbilled
      89,000 282,000                           
        deferred r&d services, current portion
      1,374,000 1,959,000                           
        inventory
      1,974,000 2,304,000 2,522,000 2,459,000 2,499,000 1,022,000 279,000                      
        prepaid expenses and other current assets
      2,368,000 3,586,000 1,492,000 1,767,000 2,344,000 2,545,000 3,066,000                      
        total current assets
      34,129,000 36,275,000 36,781,000 39,474,000 61,376,000 77,530,000 91,725,000 56,777,000 63,097,000 39,115,000 43,395,000 57,341,000 65,772,000 74,328,000 83,158,000 93,374,000 102,046,000 67,650,000 73,974,000 83,338,000 90,647,000 64,983,000 74,040,000 79,739,000 84,677,000 91,152,000 98,677,000 104,590,000 
        property and equipment
      191,000 225,000 315,000 537,000 937,000 1,052,000 3,558,000 3,688,000 3,801,000 3,887,000 4,018,000 4,044,000 4,155,000 3,894,000 3,668,000 3,648,000 3,329,000 3,102,000 2,708,000 2,517,000 2,375,000 2,090,000    255,000   
        operating lease right-of-use asset
      463,000 616,000 690,000 764,000 1,082,000 1,158,000 1,339,000 1,300,000 1,372,000 1,443,000 1,513,000 1,582,000 1,548,000 1,608,000 1,666,000 1,723,000 1,780,000 1,836,000 1,891,000  45,000 111,000 178,000 245,000 275,000    
        finance lease right-of-use asset
      1,009,000 1,050,000 945,000 1,027,000 2,460,000 1,405,000                       
        deferred r&d services, non-current portion
      2,354,000 2,354,000                           
        other non-current assets
      640,000 376,000 376,000 376,000 452,000 452,000 526,000 436,000 369,000 276,000 221,000 469,000 142,000 295,000 264,000 285,000 947,000 1,566,000 1,363,000 1,381,000 1,375,000        
        total assets
      38,786,000 40,896,000 39,107,000 42,178,000 66,307,000 81,597,000 97,148,000 62,201,000 68,639,000 44,721,000 49,147,000 63,436,000 71,617,000 80,125,000 88,756,000 99,030,000 108,102,000 74,154,000 79,936,000 87,236,000 94,442,000 68,424,000 76,074,000 81,250,000 85,979,000 91,906,000 98,805,000 104,716,000 
        liabilities and stockholders’ equity
                                  
        current liabilities:
                                  
        accounts payable
      2,193,000 1,585,000 2,321,000 1,443,000 2,527,000 2,464,000 1,925,000 2,057,000 575,000 507,000 137,000 714,000 531,000 845,000 904,000 783,000 878,000 348,000 179,000 1,297,000 1,103,000 1,185,000 1,010,000 1,467,000 1,136,000 922,000 1,067,000 1,081,000 
        accrued expenses and other current liabilities
      12,251,000 12,600,000 13,101,000 14,484,000 15,828,000 13,860,000 9,102,000 3,365,000 1,766,000 2,655,000 2,650,000 2,414,000 2,014,000 3,266,000 3,877,000 3,252,000 2,881,000 3,114,000 3,099,000 2,557,000 2,066,000        
        deferred revenue
      1,031,000 1,564,000 481,000               500,000 500,000          
        operating lease liability
      348,000 335,000 328,000 321,000 331,000 324,000 316,000 309,000 302,000 297,000 291,000 283,000 250,000 245,000 239,000 235,000 230,000 198,000 245,000 124,000 133,000 130,000 127,000 124,000 122,000    
        finance lease liability
      396,000 366,000 318,000 327,000 679,000 376,000 31,000                      
        total current liabilities
      16,219,000 28,908,000 29,222,000 29,396,000 19,365,000 17,024,000 11,374,000 5,731,000 2,643,000 3,459,000 3,078,000 45,711,000 44,800,000 46,055,000 46,374,000 45,282,000 44,658,000 39,475,000 39,003,000 38,698,000 3,302,000 3,351,000 4,330,000 4,281,000 3,062,000 2,477,000 2,451,000 3,125,000 
        r&d funding liability
      5,814,000 4,688,000                           
        total liabilities
      22,731,000 57,936,000 56,591,000 60,754,000 64,799,000 61,834,000 54,845,000 6,801,000 3,793,000 4,688,000 4,382,000 47,103,000 46,199,000 47,520,000 47,904,000 46,874,000 46,292,000 41,168,000 40,754,000 38,773,000 37,834,000 3,409,000 4,421,000 4,405,000 3,218,000 2,477,000 2,451,000 3,125,000 
        commitments and contingencies
                                  
        stockholders’ equity:
                                  
        preferred stock, 0.0001 par value...
                                  
        common stock, 0.0001 par value...
      2,000 1,000 1,000 9,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 
        treasury stock
                                  
        additional paid-in capital
      350,648,000 299,798,000 299,080,000 298,184,000 252,287,000 250,207,000 248,133,000 236,428,000 234,884,000 203,482,000 202,311,000 173,998,000 172,913,000 171,597,000 170,277,000 168,751,000 166,626,000 136,868,000 130,528,000 128,851,000 127,599,000 126,594,000 125,178,000 124,269,000 123,211,000 122,526,000 123,365,000 121,856,000 
        accumulated deficit
      -334,595,000 -316,839,000 -316,565,000 -316,769,000 -250,779,000 -230,448,000 -205,834,000 -181,032,000 -170,042,000 -163,453,000 -157,521,000 -157,604,000 -147,436,000 -138,966,000 -129,426,000 -116,597,000 -104,822,000 -103,886,000 -90,909,000 -80,423,000 -71,014,000 -61,192,000 -53,555,000 -47,465,000 -40,464,000 -33,083,000 -27,007,000 -20,268,000 
        total stockholders’ equity
      16,055,000    1,508,000 19,763,000 42,303,000 55,400,000 64,846,000 40,033,000 44,765,000 16,333,000 25,418,000 32,605,000 40,852,000 52,156,000 61,810,000 32,986,000 39,182,000 48,463,000 56,608,000 65,015,000 71,653,000 76,845,000 82,761,000 89,429,000 96,354,000 101,591,000 
        total liabilities and stockholders’ equity
      38,786,000    66,307,000 81,597,000 97,148,000 62,201,000 68,639,000 44,721,000 49,147,000 63,436,000 71,617,000 80,125,000 88,756,000 99,030,000 108,102,000 74,154,000 79,936,000 87,236,000 94,442,000 68,424,000 76,074,000 81,250,000 85,979,000    
        cash and cash equivalents
       21,097,000 15,396,000 29,595,000 48,939,000 69,547,000 84,308,000 55,140,000 59,952,000 34,273,000 32,473,000 5,430,000 10,407,000 15,752,000 20,442,000 24,706,000 44,101,000 10,686,000 17,198,000 48,932,000 54,486,000 9,241,000 10,600,000 19,852,000 24,427,000 10,271,000 38,311,000 103,149,000 
        liabilities and stockholders’ deficit
                                  
        current portion of long-term debt
       12,458,000 12,673,000 12,821,000                         
        derivative liability
       1,762,000 1,796,000 2,394,000                         
        long term debt
       21,619,000 24,578,000 27,809,000 42,848,000 42,874,000 42,401,000                      
        stockholders’ deficit:
                                  
        total stockholders’ deficit
       -17,040,000 -17,484,000 -18,576,000                         
        total liabilities and stockholders’ deficit
       40,896,000 39,107,000 42,178,000                         
        license and collaboration receivable, billed and unbilled
        8,178,000                          
        unbilled collaboration revenue
         46,000 592,000 168,000                       
        subscription receivable
          -4,000              -446,000   -410,000       
        collaboration revenue receivable
               388,000                   
        unbilled revenue
            126,000                      
        unbilled revenue receivable
             173,000 56,000                    
        prepaid expenses and other assets
             1,464,000 3,089,000 4,355,000 3,522,000 2,725,000 3,437,000 3,974,000 3,663,000 3,245,000 2,860,000 2,180,000 2,093,000 3,716,000 2,265,000 2,966,000 2,962,000 985,000 1,389,000 1,343,000 1,702,000 1,441,000 
        marketable securities
                6,981,000 8,968,000 11,497,000 54,602,000 59,053,000 65,423,000 43,585,000 54,784,000 54,683,000 30,690,000 33,896,000 52,776,000 60,478,000 58,902,000 58,855,000 79,538,000 58,664,000  
        unbilled collaboration revenue receivable
               99,000                   
        financing lease liability
                 7,000 6,000 6,000 6,000 7,000             
        debt
                 42,293,000 41,999,000 41,693,000               
        accumulated other comprehensive loss
                -29,000 -64,000 -62,000             -17,000 -7,000  
        unbilled receivable
                419,000 218,000 431,000                
        restricted cash
                 40,000,000 40,000,000                
        accumulated other comprehensive gain
                   -29,000 -2,000 -1,000 3,000 1,000 6,000 32,000 20,000 20,000 27,000 38,000 11,000    
        short term debt
                    41,348,000 41,005,000             
        license receivable
                      11,500,000            
        current debt
                      40,669,000 35,315,000 34,980,000 34,720,000         
        other liabilities
                         75,000 75,000        
        long-term debt
                          34,434,000        
        deposits
                           1,240,000 34,000 14,000 14,000 499,000 14,000 14,000 
        accrued expenses
                           2,036,000 3,193,000 2,684,000 1,804,000 1,517,000 1,346,000 2,008,000 
        accounts payable and accrued expenses - related party
                             6,000  38,000 38,000 36,000 
        property, plant and equipment
                            1,822,000 1,252,000 1,013,000  114,000 112,000 
        due to related party
                                  
        other receivable - related party
                              6,000    
        liabilities, convertible preferred stock and stockholders’ equity
                                  
        convertible preferred stock - series a - 0 and 21,302,972 shares authorized, issued and outstanding as of december 31, 2018 and december 31, 2017, respectively
                                  
        convertible preferred stock - series b - 0 and 1,937,984 shares authorized, issued and outstanding as of december 31, 2018 and december 31, 2017, respectively
                                  
        total convertible preferred stock
                                  
        stockholders’ equity
                                  
        total liabilities, convertible preferred stock and stockholders’ equity
                               91,906,000 98,805,000 104,716,000 
        convertible preferred stock - series a - 0 and 21,302,972 shares authorized, issued and outstanding as of september 30, 2018 and december 31, 2017, respectively
                                  
        convertible preferred stock - series b - 0 and 1,937,984 shares authorized, issued and outstanding as of september 30, 2018 and december 31, 2017, respectively
                                  
        convertible preferred stock - series a - 0 and 21,302,972 shares authorized, issued and outstanding as of june 30, 2018 and december 31, 2017, respectively
                                  
        convertible preferred stock - series b - 0 and 1,937,984 shares authorized, issued and outstanding as of june 30, 2018 and december 31, 2017, respectively
                                  
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2026-03-31 2025-12-31 2025-09-30 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 
                                     
          cash flows from operating activities
                                     
          net loss
        -9,682,000 -8,074,000 -274,000 -16,202,000 -22,860,000 -17,186,000 -20,331,000 -24,614,000 -24,802,000 -10,990,000 -6,589,000 -5,932,000 83,000 -10,168,000 -8,470,000 -9,540,000 -12,829,000 -11,775,000 -936,000 -12,977,000 -10,486,000 -9,409,000 -9,822,000 -7,637,000 -6,090,000 -7,001,000 -7,479,000 -6,076,000 -6,739,000 
          adjustments to reconcile net loss to net cash from operating activities:
                                     
          stock-based compensation
        897,000 686,000 718,000 756,000 2,108,000 2,228,000 2,072,000 2,075,000 9,663,000 1,544,000 1,094,000 1,171,000 1,413,000 1,085,000 1,316,000 1,321,000 1,481,000 1,848,000 1,403,000 6,340,000 1,231,000 1,252,000 998,000 802,000 905,000 846,000 780,000 -848,000 1,516,000 
          depreciation expense
        17,000 14,000 23,000 54,000 61,000 101,000 126,000 131,000 133,000 135,000 131,000 131,000 127,000 98,000 98,000 142,000 54,000 37,000 11,000 12,000 5,000 12,000 14,000 26,000 16,000 11,000 11,000 10,000 5,000 
          non-cash interest expense
         400,000 716,000  572,000                         
          loss on termination of financing lease
        10,000 -2,000 -1,000                           
          amortization of operating lease right-of-use asset
        77,000 76,000 74,000 62,000 93,000 77,000 76,000                       
          amortization of finance lease right-of-use asset
        100,000 100,000 87,000 137,000 188,000 156,000 138,000                       
          change in deferred r&d services and r&d funding liability
        1,332,000                             
          non-cash r&d expense related to torii warrant vesting
        106,000                             
          change in fair value of derivative liability
         -1,762,000 -34,000                           
          changes in operating assets and liabilities:
                                     
          prepaid expenses and other assets
        433,000 1,012,000 -2,094,000 371,000 113,000 -337,000 -1,275,000 -420,000 -1,884,000 1,625,000 1,266,000 -720,000 -784,000 511,000 537,000 -310,000 -451,000 205,000 13,000 -87,000 1,582,000 -1,410,000 701,000 -2,000 -1,977,000 404,000 -46,000 373,000 -261,000 
          collaboration receivable, billed and unbilled
        48,000 145,000                            
          inventory
        262,000  218,000                           
          accounts payable
        121,000 487,000 -736,000 931,000 -169,000 -1,382,000 52,000 578,000 121,000 1,488,000 14,000 370,000 -577,000 183,000 -314,000 -25,000 87,000 -90,000 525,000 168,000 -1,118,000 194,000 -82,000 174,000 56,000 -182,000 215,000 -145,000 341,000 
          deferred revenue
        249,000 -782,000 1,083,000             -500,000          
          accounts receivable
        -2,464,000 1,787,000 2,146,000 -201,000 10,178,000 -3,024,000 -2,753,000 86,000                      
          accrued expenses and other current liabilities
        -586,000 -400,000 -501,000 -5,180,000 896,000 2,022,000 1,968,000 5,120,000 5,458,000 1,647,000 -934,000 72,000 553,000 545,000 -1,425,000 -700,000 669,000 448,000 -209,000  442,000 519,000 279,000       
          operating lease liability
        -83,000 -82,000 -79,000 -67,000 -97,000 -79,000 -79,000 -67,000 -77,000 -73,000 -74,000 -70,000 -68,000 -66,000 -60,000 -57,000 -57,000 -56,000 -27,000 -105,000 -38,000 -32,000 -32,000 -31,000 -30,000 -30,000 -28,000   
          net cash from operating activities
        -9,163,000 -4,591,000 9,685,000 -16,064,000 -8,558,000 -16,358,000 -19,947,000 -14,507,000 -14,811,000 -4,669,000 -4,590,000 -4,954,000 1,825,000 -7,181,000 -8,340,000 -8,698,000 -10,598,000 2,499,000 -10,785,000 -6,099,000 -7,608,000 -8,594,000 -7,906,000 -8,213,000 -7,228,000 -5,050,000 -6,917,000 -6,903,000 -5,137,000 
          capital expenditures
        -16,000  -227,000 -65,000 -59,000 -11,000 -66,000 -77,000 -154,000 -5,000 -237,000 -39,000 -296,000 -311,000 -111,000 -116,000 -699,000 -3,000  -151,000 -13,000 
          free cash flows
        -9,163,000 -4,591,000 9,685,000 -16,064,000 -8,574,000 -16,358,000  -14,734,000 -14,876,000 -4,728,000 -4,601,000 -5,020,000 1,748,000 -7,335,000 -8,345,000 -8,935,000 -10,637,000 2,203,000 -11,096,000 -6,099,000 -7,719,000 -8,710,000 -8,605,000 -8,216,000 -7,228,000 -5,050,000  -7,054,000 -5,150,000 
          cash flows from investing activities
                                     
          net cash from investing activities
           8,000 -16,000   -227,000 -65,000 -59,000 -11,000 6,754,000 2,069,000 2,205,000 43,013,000 4,011,000 6,291,000 -22,135,000 10,835,000 -858,000 -24,126,000 3,130,000 18,274,000 6,650,000 -2,028,000 263,000 21,070,000 -21,146,000 -58,637,000 
          cash flows from financing activities
                                     
          repayment of debt
         -870,000 -3,890,000                          
          repayment of finance lease
        -111,000 -106,000 -94,000   -177,000 -156,000                       
          payment of equity issuance costs
        -9,000                             
          net cash from financing activities
        -120,000 13,641,000 -3,984,000 39,426,000 -397,000 -640,000 -661,000 -27,000 44,044,000 -84,000 30,280,000 -16,851,000 -1,000 -18,000 -3,000 43,000 241,000 33,365,000 445,000 -90,000 34,877,000 204,000 4,000 212,000 3,000 9,000 -1,064,000 
          net decrease in cash and restricted cash
        -9,283,000                             
          cash and restricted cash at the beginning of the period
        30,147,000                             
          cash and restricted cash at the end of the period
        20,864,000                             
          reconciliation of cash and restricted cash
                                     
          cash
        20,600,000                             
          restricted cash
        264,000                             
          total cash and restricted cash
        20,864,000                             
          loss on disposal of fixed assets
         68,000 -58,000   2,476,000                      
          change in obligation for r&d funding liability
                                     
          non-cash r&d expense related to warrant vesting
                                     
          impairment of right-of-use asset
           -5,000                          
          loss on extinguishment of debt
                                    
          purchases of property and equipment
           -16,000   -227,000 -65,000 -59,000 -11,000 -66,000 -77,000 -154,000 -5,000 -237,000 -39,000 -296,000 -311,000  -111,000 -116,000 -699,000       
          sale of fixed assets
                                     
          proceeds from exercise of stock options
           1,000 150,000 4,000 7,000     45,000 273,000 240,000 446,000 7,000 204,000 4,000 212,000 3,000   
          proceeds from issuance of debt, net of issuance costs
                                    
          proceeds from issuance of common stock, pre-funded warrants and warrants
                                     
          issuance costs for common stock, pre-funded warrants and warrants
                                     
          cash paid to settle debt
                                     
          debt amendment costs
                                     
          net decrease in cash and cash equivalents
         9,050,000 5,701,000                           
          cash and cash equivalents at the beginning of the year
                                     
          cash and cash equivalents at the end of the year
                                     
          supplemental disclosures
                                     
          cash paid for interest
           1,734,000 1,804,000 1,852,000 1,836,000 1,833,000    1,000 320,000 743,000 725,000 733,000 741,000 742,000 634,000 641,000 649,000         
          supplemental disclosure of noncash investing and financing activities:
                                     
          recognition of r&d funding liability and deferred r&d services
                                     
          non-cash accruals for equity issuance costs
                                     
          right-of-use asset obtained in exchange for lease obligation
           563,000 220,000 1,193,000 1,312,000                   
          extinguishment of finance lease liability as a result of lease termination
                                     
          extinguishment of operating lease liability as a result of lease termination
                                     
          non-cash accretion of r&d funding liability
                                     
          payment of debt amendment fees
            -17,000 -613,000 -509,000                       
          cash and cash equivalents at the beginning of the period
           69,547,000         10,686,000  9,241,000  10,271,000  
          cash and cash equivalents at the end of the period
          5,701,000  -8,971,000 -17,009,000 48,939,000  29,168,000        -4,264,000 -19,395,000 44,101,000  -31,734,000 -5,554,000 54,486,000  -9,252,000 -4,575,000 24,427,000  -64,838,000 
          license and collaboration receivable, billed and unbilled
                                     
          property and equipment purchases in accounts payable or accrued expenses and other current liabilities at period end
             3,000 11,000                       
          finance lease liability extinguished as a result of lease termination
                                     
          noncash interest expense
               472,000                      
          proceeds from issuance of common stock, pre-funded warrants and series a and b warrants, net of issuance costs
                                     
          equity issuance costs
                 -84,000 -28,000                   
          net increase in cash and cash equivalents
           23,370,000 -8,971,000 -17,009,000 -20,608,000     1,800,000    -4,690,000 -4,264,000 -19,395,000 33,415,000 -6,512,000 -31,734,000 -5,554,000 45,245,000 -1,359,000 -9,252,000 -4,575,000 14,156,000 -28,040,000 -64,838,000 
          property and equipment purchases in accounts payable or accrued expenses and other current liabilities at year end
                                     
          fair value of warrants issued with debt
                                     
          collaboration revenue receivable, billed and unbilled
            99,000 409,000 -424,000   -117,000 431,000                   
          repayment of financing lease
                   -2,000 -1,000 -1,000 -2,000 -2,000             
          proceeds from issuance of common stock and pre-funded warrants, net of issuance costs
               -1,000 30,301,000                   
          common stock warrants issued with debt
                                     
          non cash interest expense
              483,000      -242,000 326,000 300,000  352,000 336,000 393,000  269,000 263,000 65,000       
          amortization of premiums on marketable securities
                   11,000 21,000 27,000 49,000               
          gain on operating lease termination
                                     
          unbilled receivable
               -430,000     -201,000 213,000 -431,000               
          sales and maturities of marketable securities
                   7,000,000 2,008,000 2,492,000 47,508,000 14,200,000 19,200,000 15,100,000 20,500,000 12,100,000 13,394,000 20,000,000 24,355,000 24,500,000 22,650,000 28,200,000 42,365,000   
          purchases of marketable securities
                   -8,000 8,000 -4,485,000 -9,828,000 -12,870,000 -36,931,000 -9,285,000 -12,193,000 -37,409,000 -16,754,000 -5,382,000 -16,623,000 -23,999,000 -27,937,000 -21,295,000 -20,496,000  
          deposits
                     -141,000 -5,000 -124,000 -8,000 -69,000           
          debt issuance costs
                   -17,000              
          change in unrealized loss on marketable securities
                                     
          amortization in operating lease right-of-use asset
                                     
          payment of debt issuance costs
                                     
          net increase in cash, cash equivalents and marketable securities
                29,168,000 -4,812,000 25,679,000                   
          reduction in operating lease right-of-use asset
                 72,000 71,000  69,000 65,000 60,000  57,000 57,000 56,000  19,000 45,000 66,000       
          property and equipment purchases payable or accrued at period end
                  34,000 -124,000 -168,000 459,000 46,000 -30,000 -14,000 253,000 -137,000 26,000 96,000 333,000       
          cash, cash equivalents and marketable securities at the beginning of the period
                  34,273,000                   
          cash, cash equivalents and marketable securities at the end of the period
                  59,952,000                   
          gain on lease termination
                                     
          proceeds from issuance of common stock, net of issuance costs
                      -1,000 -31,000 28,150,000           
          change in unrealized gain on marketable securities
                     -2,000 -33,000  -1,000 -4,000 2,000 -5,000 -26,000   -7,000 -11,000     
          net increase in cash, cash equivalents and restricted cash
                     -4,977,000 34,655,000               
          cash, cash equivalents and restricted cash at the beginning of the period
                     15,752,000               
          cash, cash equivalents and restricted cash at the end of the period
                     -4,977,000 50,407,000               
          license receivable
                          -11,500,000           
          amortization on operating lease right-of-use asset
                               67,000 67,000 30,000 29,000   
          debt issuance cost
                                     
          repayment of subscription receivable
                           410,000       
          debt issuance costs included in accrued expenses at year end
                                     
          accretion of discounts on marketable securities
                        39,000 -11,000 -14,000 -13,000 -4,000 -28,000 -93,000 -183,000 -238,000 -283,000 -359,000 -388,000  
          proceeds from issuance of debt
                        4,975,000 34,460,000       
          subscription receivable on exercise of options
                                     
          debt issuance costs accrued at period end
                                     
          debt discount costs included in accrued expense at period end
                              125,000       
          noncash interest expense on debt
                                     
          accrued expenses
                               -1,448,000 88,000 1,143,000 4,000 171,000 46,000 
          accounts payable and accrued expenses - related party
                                 6,000 -38,000 2,000 
          purchases of property, plant and equipment
                               -3,000    -151,000 -13,000 
          increase in deposits
                                     
          other non-current assets
                                     
          other receivable - related party
                                  -6,000   
          proceeds from the issuance of common stock in connection with ipo
                                   
          payment of offering cost in connection with issuance of common stock in connection with ipo
                                   2,000 -1,064,000 
          proceeds received from issuance of series c preferred stock
                                   
          stock issuance costs related to series c preferred stock
                                   
          supplemental disclosure of cash flow information:
                                     
          conversion of preferred stock into common stock
                                   
          accrual for purchases of property, plant and equipment
                                     
          security deposits
                                     
          due to related party
                                     
          proceeds from issuance of common stock in connection with ipo, net of offering costs
                                     
          proceeds from issuance of series c preferred stock, net of issuance costs
                                     
          construction in process purchases payable or accrued at period end
                                     
          payment of offering costs in connection with issuance of common stock in connection with ipo
                                     
          fixed asset and construction in process purchases payable or accrued at period end
                                     
          issuance costs included in accounts payable and accrued expenses
                                     
          fixed asset and construction in process purchases accrued at period end
                                  285,000   
          deferred offering costs included in accounts payable and accrued expenses
                                     
          deposit for construction of equipment
                                     
          proceeds received from series a preferred stock subscription receivable
                                     
          stock issuance costs related to series a preferred stock
                                     
          fixed asset purchases accrued at period end