7Baggers
Quarterly
Annual
    Unit: USD2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 
      
    		                        
      cash flows from operating activities:
    		                        
      net income
    		-163,141,000 -110,958,000 -120,965,000 -104,589,000 -213,717,000 -138,378,000 -65,276,000 -115,973,000 -163,413,000 -194,775,000 -140,956,000 -101,603,000 175,312,000 -76,493,000 518,621,000 525,254,000 110,428,000 61,813,000 -168,911,000 -105,649,000 -84,609,000 -31,167,000 -77,240,000 -63,771,000 
      adjustments to reconcile net income to net cash from operating activities:
    		                        
      depreciation and amortization
    		2,998,000 2,917,000 2,867,000 2,886,000 2,896,000 4,260,000 4,517,000 4,347,000 4,453,000 4,615,000 5,505,000 1,820,000 1,549,000 1,463,000 1,419,000 1,387,000 1,353,000 1,269,000 1,269,000 1,215,000 1,124,000 1,061,000 1,000,000 859,000 
      amortization of premiums on investments
    		1,315,000 2,521,000 4,089,000               -647,000 409,000      
      noncash lease expense
    		1,297,000 1,237,000 1,121,000 1,099,000 1,230,000 1,472,000 1,447,000 1,440,000 1,817,000 2,228,000 2,173,000 2,236,000 2,190,000 2,172,000 2,111,000 1,701,000 1,498,000 1,489,000 1,484,000 873,000 852,000 830,000 816,000  
      change in fair value of equity investments
    		-1,335,000 3,382,000 -6,382,000 1,172,000 -1,130,000 -429,000 5,915,000 993,000 2,706,000 5,086,000 13,103,000 -8,879,000 13,591,000 11,389,000 95,039,000 26,023,000         
      change in estimated fair value of contingent consideration
    		560,000 9,980,000 1,030,000 6,940,000 2,570,000 2,989,000 1,650,000 1,661,000 -627,000 1,236,000 -1,246,000 -5,775,000 2,257,000 9,564,000 -3,931,000 28,602,000 20,328,000 -1,544,000 44,462,000 -6,038,000 16,642,000 20,625,000 7,165,000  
      payment of contingent consideration in excess of acquisition date fair value
    		0           0    0    -9,299,000 0    
      stock-based compensation
    		11,356,000 12,451,000 14,059,000 15,841,000 16,697,000 22,162,000 23,757,000 28,272,000 26,944,000 30,619,000 25,481,000 24,865,000 24,814,000 27,099,000 25,304,000 24,371,000 22,944,000 20,998,000 15,471,000 10,301,000 8,582,000 5,750,000 2,967,000 2,679,000 
      in-process research and development impairment
    		   11,038,000 0   2,759,000 0                
      long-lived assets impairment and disposal loss
    		0    2,090,000                    
      other non-cash items
    		-19,000 53,000 6,000 -162,000   -176,000                  
      changes in operating assets and liabilities:
    		                        
      prepaid expenses and other current assets
    		4,215,000 879,000 5,058,000 4,109,000 -2,180,000 6,423,000 1,834,000 10,776,000 26,896,000 17,805,000 9,493,000 -50,381,000 16,495,000 -5,225,000 -247,000 -5,543,000 1,357,000 -422,000 943,000 -4,059,000 1,743,000 -2,708,000 549,000 -4,510,000 
      other assets
    		-2,792,000 -7,332,000 6,200,000 -501,000 1,736,000 -796,000 -86,000 2,311,000 2,133,000 -299,000 -1,984,000 -8,361,000 -3,393,000 186,000 -227,000 -432,000 -194,000 -794,000 -63,000 1,068,000 -1,807,000 -236,000 -125,000 -482,000 
      accounts payable
    		-5,402,000 8,859,000 -1,415,000 -1,936,000 3,106,000 -2,893,000 735,000 2,627,000 -7,525,000 -934,000 6,564,000 2,800,000 -4,447,000 -1,385,000 3,829,000 788,000 -5,892,000 6,250,000 -1,317,000 -1,831,000 2,383,000 -14,286,000 12,944,000 536,000 
      accrued liabilities and other long-term liabilities
    		-14,155,000 -24,183,000 18,725,000 5,218,000 19,268,000 -4,770,000 -30,003,000 -39,580,000 -47,153,000 -265,729,000 -4,036,000 -80,657,000 -80,237,000 -288,175,000 433,556,000 71,988,000 8,797,000 -3,460,000 -18,827,000 33,431,000 6,392,000 16,995,000 -10,204,000 4,533,000 
      operating lease liabilities
    		-1,792,000 -1,457,000 -1,796,000 -12,595,000 -2,878,000 -3,487,000 -4,067,000 -3,136,000 -3,675,000 -3,130,000 -3,105,000 -2,955,000 -1,535,000 -519,000 -493,000 -152,000 -290,000 -97,000 4,000 -1,341,000 -786,000 -796,000 -761,000  
      deferred revenue
    		-675,000 -1,827,000 -713,000 -2,549,000 -1,505,000 482,000 -50,159,000 -2,140,000 -369,000 -1,536,000 1,700,000 -8,794,000 -40,065,000 -2,019,000 17,578,000 2,482,000 -893,000 55,057,000 35,395,000 -1,297,000 -1,735,000 -822,000 -3,189,000 1,621,000 
      net cash from operating activities
    		-167,570,000 -120,219,000 -78,116,000 -87,635,000 -171,480,000 -77,847,000 -109,390,000 -107,927,000 -155,829,000 -389,247,000 -125,782,000 35,126,000 117,902,000 960,136,000 550,089,000 7,695,000 -105,813,000 140,058,000 -89,529,000 -82,052,000 -49,841,000 -10,639,000 -48,409,000 -38,885,000 
      capex
    		0 -2,538,000 -1,629,000 0 -2,356,000 -666,000 -1,872,000 -1,535,000 -3,714,000 -9,457,000 -6,867,000 -12,596,000 -18,993,000 -20,598,000 -15,841,000 -13,067,000 -6,006,000 -2,077,000 -667,000 0 -1,474,000 -1,343,000 -1,302,000 0 
      free cash flows
    		-167,570,000 -122,757,000 -79,745,000 -87,635,000 -173,836,000 -78,513,000 -111,262,000 -109,462,000 -159,543,000 -398,704,000 -132,649,000 22,530,000 98,909,000 939,538,000 534,248,000 -5,372,000 -111,819,000 137,981,000 -90,196,000 -82,052,000 -51,315,000 -11,982,000 -49,711,000 -38,885,000 
      cash flows from investing activities:
    		                        
      proceeds from sale of equipment
    		37,000 45,000 281,000  5,000 379,000 533,000                  
      purchases of long-lived assets
    		                        
      purchases of investments
    		-264,447,000 -192,371,000 -173,694,000 -160,859,000 -240,141,000 -271,400,000 -562,939,000 -818,990,000 -502,910,000 -309,776,000 -384,513,000 -407,213,000 -728,459,000 -251,730,000 -89,563,000 -364,511,000 0 -50,729,000 -5,000,000 -40,442,000 -233,500,000 -89,427,000 -40,472,000  
      maturities and sales of investments
    		305,173,000 251,320,000 301,860,000 301,136,000 361,507,000 483,294,000 592,698,000                  
      net cash from investing activities
    		40,446,000 56,456,000 126,818,000 140,737,000 118,603,000 211,607,000 28,420,000 -104,811,000 -58,954,000 230,315,000 98,079,000 -153,135,000 -662,605,000 -272,329,000 -105,392,000 -377,582,000 73,859,000 75,375,000 87,534,000 60,713,000 -185,379,000 10,585,000 104,219,000 -73,769,000 
      cash flows from financing activities:
    		                        
      proceeds from exercise of stock options
    		101,000 649,000 598,000 89,000 71,000 409,000 221,000 89,000 343,000 742,000 2,310,000 932,000 2,044,000 1,074,000 484,000 3,442,000 3,690,000 3,593,000 2,352,000 519,000 1,152,000 2,245,000 143,000 63,000 
      issuance of common stock under espp
    		0    0    0    0            
      other financing activities
    		1,000                        
      net cash from financing activities
    		102,000 2,046,000 598,000 1,263,000 31,000 2,942,000 152,000 1,680,000 277,000 3,179,000 2,344,000 2,011,000 1,985,000 3,080,000 27,685,000 5,670,000 3,629,000 3,529,000 87,503,000 -259,000 324,308,000 205,340,000 85,000 130,100,000 
      net increase in cash, cash equivalents and restricted cash and cash equivalents
    		-127,022,000 -61,717,000 49,300,000 54,365,000 -52,846,000   -211,058,000 -214,506,000 -155,753,000 -25,359,000 -115,998,000 -542,718,000 690,887,000 472,382,000 -364,217,000 -28,325,000 218,962,000 85,508,000 -21,598,000 89,088,000 205,286,000 55,895,000 17,446,000 
      cash, cash equivalents and restricted cash and cash equivalents at beginning of period
    		0 0 318,695,000 0 0 0 261,292,000 0 0 0 867,968,000 0 0 0 363,415,000 0 0 0 451,487,000 0 0 0 122,816,000 0 
      cash, cash equivalents and restricted cash and cash equivalents at end of period
    		-127,022,000 -61,717,000 367,995,000 54,365,000 -52,846,000 136,702,000 180,474,000 -211,058,000 -214,506,000 -155,753,000 842,609,000 -115,998,000 -542,718,000 690,887,000 835,797,000 -364,217,000 -28,325,000 218,962,000 536,995,000 -21,598,000 89,088,000 205,286,000 178,711,000 17,446,000 
      noncash investing and financing activities:
    		                        
      obtaining a right-of-use asset in exchange for a lease liability
    		-262,000                        
      supplemental disclosure of cash flow information:
    		                        
      net cash paid for income tax
    		4,532,000                        
      reconciliation of cash, cash equivalents and restricted cash and cash equivalents to the condensed consolidated balance sheets:
    		                        
      cash and cash equivalents
    		-41,020,000 -62,467,000 273,571,000 54,597,000 -128,514,000 136,153,000 160,711,000 -210,524,000 -214,849,000 -157,964,000 824,913,000 -115,104,000 -541,448,000 692,828,000 812,355,000 -366,706,000 -27,430,000 220,555,000 521,396,000 -25,946,000 90,740,000 203,363,000 168,418,000 15,637,000 
      restricted cash and cash equivalents, current
    		-86,003,000 67,000 88,151,000 -213,000 75,652,000 611,000 13,335,000 75,000 30,000 2,206,000 10,957,000 -274,000 -192,000 -1,255,000 14,402,000 2,482,000 -892,000 -1,597,000 8,601,000 -1,370,000 -1,661,000 1,923,000 9,101,000 -2,641,000 
      restricted cash and cash equivalents, noncurrent
    		1,000 683,000 6,273,000 -19,000 16,000 -62,000 6,428,000 -609,000 313,000 5,000 6,739,000 -620,000 -1,078,000 -686,000 9,040,000 7,000 -3,000 4,000 6,998,000 5,718,000 9,000 0 1,192,000 4,450,000 
      total cash, cash equivalents and restricted cash and cash equivalents
    		-127,022,000 -61,717,000 367,995,000 54,365,000 -52,846,000 136,702,000 180,474,000  -214,506,000                
      purchases of property and equipment
    		 -2,538,000 -1,629,000  -2,356,000 -666,000 -1,872,000 -1,535,000 -3,714,000 -9,457,000 -6,867,000 -12,596,000 -18,993,000 -20,598,000 -15,841,000 -13,067,000 -6,006,000 -2,077,000 -667,000  -1,474,000 -1,343,000 -1,302,000  
      change in estimated constraint on profit-sharing amount
    		    0 0 685,000  -1,816,000 5,256,000 -31,541,000  -43,907,000            
      payment of principal on financing lease obligation
    		    -40,000 -69,000 -69,000  -66,000 -68,000 -66,000  -59,000 -60,000 -64,000  -61,000 -64,000 -62,000      
      changes in estimated constraint on profit-sharing amount
    		                        
      amortization of premiums (accretion of discounts) on investments
    		   2,168,000 354,000 2,637,000 238,000       659,000 1,073,000     496,000 234,000 256,000 562,000 392,000 
      change in deferred income taxes
    		   -2,643,000 57,000                    
      non-cash restructuring, long-lived assets impairment and related charges
    		                        
      receivable from collaboration
    		   -8,747,000 -54,000 2,689,000 -401,000 -3,606,000 0 948,000 2,093,000 278,166,000 58,183,000 883,771,000 -450,082,000 -680,076,000         
      proceeds from sale of property and equipment
    		                        
      purchases of property, equipment and intangible assets
    		                        
      proceeds from issuance of common stock under espp
    		                        
      proceeds from issuance of common stock in connection with a grant agreement
    		           0 0 0 28,462,000          
      payment of contingent consideration
    		           0 0 0 -1,197,000     -701,000 0    
      net refund received (cash paid) for income tax
    		                        
      reconciliation of cash, cash equivalents and restricted cash and cash equivalents to the consolidated balance sheets:
    		                        
      other
    		       731,000 -750,000 -34,000 206,000 -684,000 9,000 83,000 209,000 211,000 454,000 13,000 19,000 6,000 6,000 6,000 5,000  
      contributions from noncontrolling interest owners
    		       0 0 0 100,000              
      increase in ownership interest in a subsidiary
    		       0 0                
      assets:
    		                        
      money market funds
    		                        
      u.s. government treasuries
    		                        
      u.s. government agency bonds and discount notes
    		                        
      asset-backed securities
    		                        
      corporate bonds
    		                        
      equity securities
    		                        
      total financial assets
    		                        
      net decrease in cash, cash equivalents and restricted cash and cash equivalents
    		      -80,818,000                  
      yankee bonds
    		                        
      amortization of intangible assets
    		       132,000 133,000 133,000 133,000 133,000 133,000 133,000 133,000 134,000 133,000 133,000 133,000 124,000 306,000 306,000 306,000 305,000 
      accretion of discounts on investments
    		       1,351,000                 
      gain from a sublease termination
    		                        
      proceeds from issuance of common stock under the employee stock purchase plan
    		                        
      payment of principal on financing lease obligations
    		                     -57,000 -58,000 -57,000 
      proceeds from issuance of common stock in connection with a collaboration agreement
    		               0 0 0 85,213,000 0 0    
      total cash, cash equivalents and restricted cash
    		          842,609,000 -115,998,000 -542,718,000 690,887,000 835,797,000 -364,217,000 -28,325,000 218,962,000 536,995,000 -21,598,000 89,088,000 205,286,000 178,711,000  
      long-lived assets impairment
    		        2,108,000                
      proceeds from sale of an equipment
    		            11,000 -1,000 12,000          
      maturities of investments
    		        447,670,000 549,548,000 489,459,000 266,674,000    0 79,861,000 128,181,000 93,201,000 103,585,000 49,595,000 101,355,000 145,813,000  
      adjustments to reconcile net income to net cash (used in) provided for operating activities:
    		                        
      (accretion of discounts) amortization of premiums on investments
    		         -3,001,000 -9,365,000              
      impairment of intangible assets
    		                   0     
      change in estimated fair value of derivative liability
    		                   0 0 0 16,796,000  
      proceeds from disposal of an asset held for sale
    		                   0     
      proceeds from issuance of common stock, net of issuance costs
    		                   0     
      property and equipment purchases included in accounts payable and accrued liabilities
    		           -5,393,000 -2,342,000 417,000 8,338,000 4,540,000 1,706,000 2,107,000 378,000 -216,000 286,000 -209,000 521,000 692,000 
      common stock issued for payment of contingent consideration
    		               0         
      operating lease liabilities obtained in exchange of right-of-use asset
    		           77,000 27,000 720,000 3,222,000 77,097,000    48,058,000     
      reclassification of derivative liability to additional paid-in capital
    		                   0 0 0 29,245,000  
      supplemental disclosure of cashflow information:
    		                        
      cash paid during the period for income tax
    		           60,377,000 102,237,000            
      reconciliation of cash, cash equivalents and restricted cash to the consolidated balance sheets:
    		                        
      proceeds from disposal of an equipment
    		                        
      supplemental disclosure of cashflow information
    		                        
      reconciliation of cash, cash equivalents and restricted cash to the condensed consolidated balance sheets:
    		                        
      payment for contingent consideration in excess of acquisition date fair value
    		             0 -93,803,000          
      initial fair value of derivative liability
    		                        
      change in estimated fair value of convertible preferred stock warrant liability
    		                       -1,352,000 
      common stock issued in connection with license agreement
    		                       0 
      proceeds from issuance of convertible preferred stock, net of issuance costs
    		                       0 
      proceeds received from financing lease obligation
    		                        
      proceeds from repayment of promissory notes
    		                       0 
      cash paid in lieu of fractional shares related to reverse stock split
    		                        
      conversion of preferred stock into common stock upon completion of initial public offering
    		                        
      advanced proceeds applied to convertible preferred stock issuance
    		                        
      reclassification of preferred stock warrant liability to additional paid-in capital
    		                        
      deferred offering costs in accounts payable and accrued liabilities
    		                        
      preferred stock issued in connection with asset acquisition
    		                        
      loss on write-off and disposal of property and equipment
    		                        
      purchase of property and equipment
    		                        
      asset acquisitions
    		                        
      advanced proceeds from convertible preferred stock financing
    		                        
      issuance of preferred stock in connection with asset acquisition
    		                        
      payment of offering costs related to initial public offering
    		                        
      proceeds from disposal of an asset held sale
    		                     0 180,000  
      business acquisition, net of cash acquired
    		                        
      proceeds from issuance of common stock in initial public offering, net of issuance costs
    		                        
      proceeds received from financing obligation
    		                       0 
      common stock issued in connection with business acquisition
    		                        
      contingent consideration recorded in connection with business acquisitions
    		                        
      issuance costs for convertible preferred stock in accounts payable and accrued liabilities
    		                        
      receipt of promissory note from related parties for purchase of common stock
    		                        
      loss on disposal of property and equipment
    		                        
      change in fair value of contingent consideration
    		                        
      purchases of short-term investments
    		                        
      maturities of short-term investments
    		                        
      issuance costs for convertible preferred stock included in accounts payable and accrued liabilities
    		                        
      deferred issuance costs incurred and not paid
    		                        
    The information provided in this report is taken from www.sec.gov and many other data providers. While we have conducted our best efforts to ensure that the parsed data is accurate, we cannot guarantee its accuracy. Please use caution and understand that any consequences of its use are your own responsibility.