7Baggers

TG Therapeutics, Inc
(NASDAQ:TGTX) 

TGTX stock logo

TG Therapeutics, Inc., a commercial stage biopharmaceutical company, focuses on the acquisition, development, and commercialization of novel treatments for B-cell malignancies and autoimmune diseases. Its therapeutic product candidates include Ublituximab, an investigational glycoengineered monoclon...

Founded: 1993
Full Time Employees: 217
Sector: Healthcare
Industry: Biotechnology

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At a glance:
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Moat:
Income Statements:
Quarterly
Annual
    Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-05-10 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 2009-12-31 2009-09-30 2009-06-30 2009-03-31 2008-12-31 2008-09-30 2008-06-30 2008-03-31 2007-12-31 2007-09-30 2007-08-06 2007-06-30 2007-03-31 
                                                                                  
      revenue:
                                                                                  
      product revenue
    201,308,000 189,113,000 159,317,000 138,843,000 119,655,000 107,347,000 83,297,000 72,596,000 50,488,000 43,137,000 25,068,000 16,036,000 7,765,000 42,000 56,000 556,000 1,978,000 2,283,000 1,992,000 1,507,000 755,000                                                          
      license, milestone, royalty and other revenue
    3,610,000 3,461,000 2,392,000 2,305,000 1,201,000 838,000 582,000 870,000 12,986,000                                                                      
      total revenue
    204,918,000 192,574,000 161,709,000 141,148,000 120,856,000 108,185,000 83,879,000 73,466,000 63,474,000 43,971,000 165,815,000 16,074,000 7,803,000 80,000 94,000 594,000 2,016,000 2,321,000 2,030,000 1,545,000 793,000                                                          
      yoy
    69.56% 78.00% 92.79% 92.13% 90.40% 146.04% -49.41% 357.05% 713.46% 54863.75% 176298.94% 2606.06% 287.05% -96.55% -95.37% -61.55% 154.22%                                                              
      qoq
    6.41% 19.09% 14.57% 16.79% 11.71% 28.98% 14.17% 15.74% 44.35% -73.48% 931.57% 106.00% 9653.75% -14.89% -84.18% -70.54% -13.14% 14.33% 31.39% 94.83%                                                           
      costs and expenses:
                                                                                  
      cost of revenue
    33,510,000 38,142,000 28,093,000 18,938,000 15,541,000 15,399,000 9,341,000 8,304,000 5,441,000 7,854,000 3,509,000                                                                    
      research and development:
                                                                                  
      stock-based compensation
    4,875,000                                                                              
      other research and development
    43,521,000 37,559,000 35,543,000 27,464,000 43,031,000 20,714,000 17,110,000 15,036,000 30,270,000 14,601,000 11,838,000 22,458,000 14,286,000 23,882,000 17,552,000 24,546,000 46,147,000 57,660,000 47,433,000 37,855,000 55,583,000 37,149,000 45,846,000 34,896,000 34,043,000 29,455,000 56,503,000 31,414,000 30,896,000 30,896,000 51,069,000 32,754,000 34,812,000 32,159,000 25,736,101 25,334,762 25,439,477 20,375,794 21,414,723 20,878,108 12,966,574 11,230,415 13,725,926 11,538,246 9,902,214 8,279,431 12,807,504 8,352,154 2,336,771 2,508,258 3,606,385 3,138,119 4,661,455 1,215,202 860,222 1,433,711 1,536,896 163,353                     
      total research and development
    48,396,000 41,193,000 40,878,000 31,782,000 46,362,000 23,874,000 20,138,000 17,556,000 32,722,000 17,449,000 14,753,000 28,122,000 15,870,000 29,635,000 20,801,000 26,874,000 48,042,000 62,646,000 51,967,000 44,871,000 63,094,000 42,961,000 50,464,000 36,449,000 36,022,000 30,943,000 57,985,000 32,866,000 32,385,000 32,385,000 52,276,000 33,398,000 38,700,000 35,018,000 25,996,108 27,149,050 26,705,799 22,681,893 22,283,347 21,797,756 13,533,731 11,617,340 15,254,222 11,574,002 11,261,660 9,617,339 15,136,774 13,691,573 6,848,132 4,409,868 3,755,591 3,309,561 5,027,623 1,569,905 1,079,742 1,560,802 1,646,094 16,741,353                     
      selling, general and administrative:
                                                                                  
      other selling, general and administrative
    73,142,000 50,727,000 51,022,000 43,541,000 38,691,000 30,175,000 33,221,000 31,828,000 27,694,000 24,616,000 26,500,000 23,838,000 22,828,000 17,206,000 10,514,000 15,942,000 20,383,000 23,042,000 25,436,000 24,729,000 17,655,000                                                          
      total selling, general and administrative
    88,217,000 62,745,000 63,373,000 55,585,000 50,331,000 38,963,000 41,966,000 38,790,000 34,581,000 31,153,000 32,769,000 30,715,000 28,068,000 22,504,000 14,254,000 12,638,000 20,609,000 32,412,000 34,899,000 34,017,000 26,762,000                                                          
      total costs and expenses
    170,123,000 142,080,000 132,344,000 106,305,000 112,234,000 78,236,000 71,445,000 64,650,000 72,744,000 56,456,000 51,031,000 60,748,000 44,795,000 52,142,000 35,057,000 39,535,000 68,888,000 95,268,000 87,158,000 79,036,000 89,995,000 86,820,000 85,760,000 50,883,000 50,283,000 37,999,000 60,899,000 35,582,000 34,727,000 34,727,000 54,188,000 34,366,000 44,383,000 40,615,000 31,072,826 31,623,323 28,463,466 27,704,517 24,066,153 24,963,567 16,061,538 14,030,251 17,678,096 13,863,680 17,149,675 14,640,946 18,759,219 17,477,442 11,993,592 7,643,220 8,013,861 4,685,513 6,666,860 3,752,136 3,709,637 2,714,226 3,104,930 17,385,354                     
      operating income
    34,795,000 50,494,000 29,365,000 34,843,000 8,622,000 29,949,000 12,434,000 8,816,000 -9,270,000 -12,485,000 114,784,000 -44,674,000 -36,992,000 -52,062,000 -34,963,000 -38,941,000 -66,872,000 -92,947,000 -85,128,000 -77,492,000 -89,202,000 -86,782,000 -85,722,000 -50,845,000 -50,245,000 -37,961,000 -60,861,000 -35,544,000 -34,689,000 -34,689,000 -54,150,000 -34,328,000 -44,345,000 -41,577,000 -31,034,731 -31,585,227 -28,425,371 -27,666,422 -24,028,058 -24,925,471 -16,023,443 -13,992,156 -17,640,001 -13,825,584 -17,111,580 -14,602,851 -18,721,124 -17,439,346 -11,955,497 -7,605,125 -7,975,766 -4,647,417 -6,628,765 -3,714,041 -3,690,589 -2,714,226 -3,104,930 -17,385,354 -261,843 -322,906 -566,085 -446,569 -515,631 -525,091 -529,445 -341,321 -395,640 -477,260 -557,336 52,253 -1,383,558 -1,467,266 -1,614,131 -1,918,756 -2,707,021 -45,141,536 -4,924,008 -45,141,536 
      yoy
    303.56% 68.60% 136.17% 295.22% -193.01% -339.88% -89.17% -119.73% -74.94% -76.02% -428.30% 14.72% -44.68% -43.99% -58.93% -49.75% -25.03% 7.10% -0.69% 52.41% 77.53% 128.61% 40.85% 43.05% 44.84% 9.43% 12.39% 3.54% -21.77% -16.57% 74.48% 8.68% 56.00% 50.28% 29.16% 26.72% 77.40% 97.73% 36.21% 80.29% -6.36% -4.18% -5.77% -20.72% 43.13% 92.01% 134.73% 275.25% 80.36% 104.77% 116.11% 71.22% 113.49% -78.64% 1309.47% 740.56% 448.49% 3793.09% -49.22% -38.50% 6.92% 30.84% 30.33% 10.02% -5.00% -753.21% -71.40% -67.47% -65.47% -102.72% -48.89% -96.75% -67.22% -95.75%     
      qoq
    -31.09% 71.95% -15.72% 304.12% -71.21% 140.86% 41.04% -195.10% -25.75% -110.88% -356.94% 20.77% -28.95% 48.91% -10.22% -41.77% -28.05% 9.18% 9.85% -13.13% 2.79% 1.24% 68.59% 1.19% 32.36% -37.63% 71.23% 2.46% 0.00% -35.94% 57.74% -22.59% 6.66% 33.97% -1.74% 11.12% 2.74% 15.14% -3.60% 55.56% 14.52% -20.68% 27.59% -19.20% 17.18% -22.00% 7.35% 45.87% 57.20% -4.65% 71.62% -29.89% 78.48% 0.64% 35.97% -12.58% -82.14% 6539.61% -18.91% -42.96% 26.76% -13.39% -1.80% -0.82% 55.12% -13.73% -17.10% -14.37% -1166.61% -103.78% -5.71% -9.10% -15.88% -29.12% -94.00% 816.76% -89.09%  
      operating margin %
    16.98% 26.22% 18.16% 24.69% 7.13% 27.68% 14.82% 12.00% -14.60% -28.39% 69.22% -277.93% -474.07% -65077.50% -37194.68% -6555.72% -3317.06% -4004.61% -4193.50% -5015.66% -11248.68% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% 
      other expense:
                                                                                  
      interest expense
    7,666,000 6,533,000 6,721,000 6,716,000 6,757,000 7,061,000 10,832,000 3,977,000 2,288,000 2,431,000 3,713,000 3,627,000 2,844,000 2,862,000 1,648,000 3,017,000 2,664,000 1,079,000 1,038,000 1,623,000 1,898,000 1,291,000 1,610,000 2,228,000 1,201,000 1,899,000 1,537,000 1,077,000           168,674.75 211,538 220,756 242,405 242,026 246,527 246,526 237,657 234,787 234,787 234,787 226,340 240,872 240,530 240,014 231,472 228,901 228,585 228,109 220,149 1,165,078 428,210 289,598 234,388.75 349,562 351,215 236,777 99,174.5 136,738 134,510 125,450 45,986 18,804    26,033  26,033 
      loss on extinguishment of debt
    9,153,000                                                                              
      other income
    -2,387,000 -1,132,000 -3,265,000 -2,793,000 -3,603,000 -2,565,000 -2,666,000 -1,712,000 -880,000 -890,000 -2,859,000 -691,000 -604,000 -1,930,000 -793,000 -1,448,000 -523,000 -688,000 -529,000 -618,000 -472,000 145,000 -169,000 -189,000 -330,000 -288,000 -468,000 -408,000  616,000         -8,260.5 -33,042          -95,427       -272,232                      
      total other expense
    14,432,000 5,401,000 3,456,000 3,923,000 3,154,000 4,496,000 8,166,000 2,265,000 1,408,000 1,541,000 854,000 2,936,000 2,240,000 932,000 855,000 1,569,000 2,141,000 391,000 509,000 1,005,000 1,426,000 1,436,000 1,441,000 2,039,000 871,000 1,611,000 1,069,000 669,000 467,000     -48,000 -15,193.75 -49,575 -72,287 61,087     -28,189 -169,668 -8,397  75,305 11,823 30,933     -40,430    11,184 289,896 2,659,633 -4,398,468 -811,800 -556,878 -2,375,427 1,103,724 -118,408 20,449  204,508 -17,269.5 10,758        
      net income before taxes
    20,363,000 45,093,000 25,909,000 30,920,000 5,468,000 25,453,000 4,268,000 6,551,000                                                                       
      income tax expense
    -586,000    408,000 22,250 388,000                                                                        
      net income
    19,777,000 23,037,000 390,895,000 28,187,000 5,060,000 23,331,000 3,880,000 6,879,000 -10,707,000 -14,416,000 113,930,000 -47,610,000 -39,232,000 -52,994,000 -35,818,000 -40,510,000 -69,013,000 -93,338,000 -85,637,000 -78,497,000 -90,628,000 -88,218,000 -87,163,000 -52,884,000 -51,116,000 -39,572,000 -61,930,000 -36,213,000 -35,156,000 -35,156,000 -53,860,000 -33,951,000 -44,142,000 -41,529,000 -30,859,767 -31,535,652 -28,353,084 -27,727,509 -23,674,143 -24,831,027 -15,899,062 -13,848,662 -17,611,812 -13,655,916 -17,103,183 -14,577,735            -17,396,538 -551,739 -2,982,539 3,832,383 365,231 41,247 1,850,336 -1,633,169 -222,913 -416,089 -1,392,437 -761,844 127,019 -1,394,316 -1,422,212 -1,559,474 -1,904,174 -2,669,421 -44,351,431 -4,894,400 -44,351,431 
      yoy
    290.85% -1.26% 9974.61% 309.75% -147.26% -261.84% -96.59% -114.45% -72.71% -72.80% -418.08% 17.53% -43.15% -43.22% -58.17% -48.39% -23.85% 5.80% -1.75% 48.43% 77.30% 122.93% 40.74% 46.04% 45.40% 12.56% 14.98% 6.66% -20.36% -15.35% 74.53% 7.66% 55.69% 49.78% 30.35% 27.00% 78.33% 100.22% 34.42% 81.83% -7.04% -5.00%                -4863.16% -1437.65% -261.19% -334.66% -263.84% -109.91% -232.88% 114.37% -275.50% -70.16% -2.09% -51.15% -106.67% -47.77% -96.79% -68.14% -95.71%     
      qoq
    -14.15% -94.11% 1286.79% 457.06% -78.31% 501.31% -43.60% -164.25% -25.73% -112.65% -339.30% 21.36% -25.97% 47.95% -11.58% -41.30% -26.06% 8.99% 9.10% -13.39% 2.73% 1.21% 64.82% 3.46% 29.17% -36.10% 71.02% 3.01% 0.00% -34.73% 58.64% -23.09% 6.29% 34.57% -2.14% 11.22% 2.26% 17.12% -4.66% 56.18% 14.81% -21.37% 28.97% -20.16% 17.32%             3053.04% -81.50% -177.82% 949.30% 785.47% -97.77% -213.30% 632.65% -46.43% -70.12% 82.77% -699.79% -109.11% -1.96% -8.80% -18.10% -28.67% -93.98% 806.17% -88.96%  
      net income margin %
    9.65% 11.96% 241.73% 19.97% 4.19% 21.57% 4.63% 9.36% -16.87% -32.79% 68.71% -296.19% -502.78% -66242.50% -38104.26% -6819.87% -3423.26% -4021.46% -4218.57% -5080.71% -11428.50% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% -Infinity% -Infinity% -Infinity% Infinity% Infinity% Infinity% Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% 
      net income per common share:
                                                                                  
      basic
    140 200 2,690 190 30  30 50  -100 800                                                                    
      diluted
    120 150 2,430 170 30  20 40  -100 730                                                                    
      weighted-average shares of common stock outstanding
                                                                                  
      basic
    144,439,370,000 144,316,786,000 145,416,901,000 146,739,833,000 146,677,783,000 145,317,418,000 145,102,479,000 144,727,482,000  141,955,112,000 142,871,227,000                                                                    
      diluted
    160,062,326,000 161,412,746,000 160,997,977,000 162,559,404,000 162,769,202,000 160,336,051,000 160,714,388,000 159,423,571,000  148,508,465,000 155,871,749,000                                                                    
      noncash compensation
     3,634,000 5,335,000 4,318,000 3,331,000 3,160,000 3,028,000 2,520,000 2,452,000 2,848,000 2,915,000 5,664,000 1,584,000 5,753,000 3,249,000 2,328,000 1,895,000 4,986,000 4,534,000 7,016,000 7,511,000 5,812,000 4,618,000 1,553,000 1,979,000 1,488,000 1,482,000 1,352,000 1,489,000 1,489,000 1,207,000 644,000 888,000 2,859,000 260,007 1,814,288 1,266,322 2,306,099 868,624 919,648 567,157 386,925 1,528,296 35,756 1,359,446 1,337,908 2,329,270 1,200,575 3,300,111 1,901,610 149,206 171,442 366,168 354,703 219,520 127,091 109,198                      
      income tax benefit
     -22,056,000 364,986,000 -2,733,000    328,000                                                                       
      net loss before taxes
            -10,678,000                                                                      
      income taxes
            29,000                                                                      
      basic and diluted net loss per common share
            -70   -340 -280 -380 -260 -300 -510 -700 -650 -590 -690 -720 -730 -470 -480 -410 -690 -420 -430  -690 -430 -590 -590 -0.46 -0.48 -0.45 -0.52 -0.49 -0.5 -0.33 -0.28 -0.37 -0.28 -0.38 -0.35 -0.5 -0.51 -0.36 -0.25 -0.19 -0.16 -0.29 -0.17 -0.04 -0.16 -0.16 -2.03                     
      weighted-average shares used for eps calculation
            146,209,213,000   141,503,738,000 140,312,269,000 135,411,258,000 135,327,035,000 134,779,904,000 134,400,500,000 132,222,753,000 132,353,119,000 132,072,996,000 131,898,626,000 115,333,693,000 119,176,336,000 112,353,414,000 105,461,892,000 88,368,844,000 89,667,979,000 86,800,017,000 81,174,301,000 81,174,301,000 75,466,813,000 78,221,069,000 74,256,348,000 70,636,970,000 62,069,570 65,079,128 63,288,269 53,157,851 49,041,354 49,203,277 48,769,948 48,908,278 45,646,414 47,946,309 45,320,637 41,088,752 34,068,926 34,188,108 32,985,130 30,091,000 25,413,964 27,684,802 22,483,394 21,953,803 13,113,758 15,810,299 11,777,563 5,061,399                     
      license, milestone and other revenue
             834,000 140,747,000                                                                    
      ​
                                                                                  
      weighted-average shares outstanding:
                                                                                  
      basic
    144,439,370,000 144,316,786,000 145,416,901,000 146,739,833,000 146,677,783,000 145,317,418,000 145,102,479,000 144,727,482,000  141,955,112,000 142,871,227,000                                                                    
      diluted
    160,062,326,000 161,412,746,000 160,997,977,000 162,559,404,000 162,769,202,000 160,336,051,000 160,714,388,000 159,423,571,000  148,508,465,000 155,871,749,000                                                                    
      license revenue
               38,000 38,000 38,000 38,000 38,000 38,000 38,000 38,000 38,000 38,000 38,000 38,000 38,000 38,000 38,000 38,000 38,000 38,000 38,000 38,000 38,000 38,000 38,000 38,095 38,096 38,095 38,095 38,095 38,096 38,095 38,095 38,095 38,096 38,095 38,095 38,095 38,096 38,095 38,095 38,095 38,096 38,095 38,095                         
      cost of product revenue
               1,911,000 857,000 3,000 2,000 23,000 237,000 210,000 292,000 148,000 139,000                                                          
      noncash stock expense associated with in-licensing agreements
                                                                                  
      general and administrative:
                                                                                  
      other general and administrative
                         16,150,000 11,584,000 8,617,000 5,172,000 2,924,000 2,321,000 2,311,000 1,949,000 1,949,000 1,661,000 1,785,000 2,308,000 2,119,000 1,766,747 1,398,438 1,534,261 1,333,268 1,322,831 1,251,421 1,446,567 1,100,871 1,095,126 1,085,400 1,004,475 1,004,487 913,279 889,872 706,725 903,524 662,728 550,639 631,637 651,457 501,123 462,425 396,043 455,492                     
      total general and administrative
                         43,859,000 35,296,000 14,434,000 14,261,000 7,056,000 2,914,000 2,716,000 2,342,000 2,342,000 1,912,000 968,000 5,683,000 6,597,000 5,076,718 4,474,273 1,757,667 5,022,624 1,782,806 3,165,811 2,527,807 2,412,911 2,423,874 2,289,678 5,888,015 5,023,607 3,622,445 3,785,869 5,145,460 3,233,352 1,460,670 1,375,952 1,639,237 2,182,231 1,525,195 1,153,424 1,458,836 644,001                     
      other expense :
                                                                                  
      noncash stock expense associated with in–licensing agreements
                             25,000                                                     
      non-cash stock expense associated with in–licensing agreements
                               100,000   1,000,000  3,000,000                                              
      interest income
                                -149,000 -149,000 -266,000 -258,000 -189,000 -144,000 -120,422 -79,163 -50,197 -44,696 -57,576 -87,965 -92,629 -84,862 -64,993 -55,977 -31,551 -22,132 -16,741 -12,107 -12,727 -13,474 -15,768 -12,375 -1,177 -1,502 -3,076 -4,951 -4,092 -3,668                     
      other expense
                                616,000  -24,000 -119,000 -14,000 96,000   -22,090 105,783                                         
      other income:
                                                                                  
      total other income
                                 467,000 -290,000 -377,000 -203,000      -90,579.75 -94,444 -124,381 -143,494    -25,116    -57,876 -2,311,914 -91,222 -44,213  -130,903 -4,025            915,177    -45,054 -54,657 -14,582 -37,600 -790,105 -29,608 -790,105 
      basic and diluted net income per common share
                                 -430                                                 
      other
                                      28,320.25 29,588                                           
      change in fair value of notes payable
                                          -184,630 -184,975 -252,508 -301,037 -205,222 -360,218 -223,372 -240,641 -142,741 -210,857 -191,127 -175,315 -2,428,124 -319,377 -283,050 -270,400 -744,360 -227,659 -482,556                      
      noncash stock expense associated with in-licensing agreement
                                                    1,211,250                              
      noncash stock expense associated with in- licensing agreements
                                                  1,337,523.5 4,138,844                               
      consolidated net incomes
                                                  -9,246,212 -17,451,169 -11,986,430 -7,547,249 -5,663,852 -4,556,195 -6,584,552 -3,673,611 -3,502,054 -2,710,201 -2,574,159                      
      impairment of in-process research and development
                                                                                  
      income before income taxes
                                                     -7,547,249 -5,663,852 -4,556,195 -6,584,552 -3,673,611                         
      net loss attributable to non-controlling interest
                                                             -7,140,448                     
      net loss attributable to tg therapeutics, inc. and subsidiaries
                                                     -7,547,249 -5,663,852 -4,556,195 -6,584,552 -3,673,611 -3,459,737 -2,462,239 -1,894,653 -10,256,090                     
      net loss attributable to noncontrolling interest
                                                          -2,016,979 -247,962 -679,506                      
      noncash stock expense associated with in- licensing agreement
                                                          4,144,500                        
      total other
                                                            -530,771                      
      non-cash stock expense associated with in-licensing agreement
                                                             16,578,000                     
      non-cash compensation
                                                             188,509                     
      change in fair value of non-current notes payable
                                                             -205,297                     
      revenue
                                                                                  
      research and development
                                                              95,897 90,218 355,177 190,293 236,734 50,999 17,767 -16,778 5,574 6,644 44,936 -61,860 498,853 565,728 800,071 1,175,647 1,808,958  3,871,634  
      general and administrative
                                                              165,946 232,688 210,908 256,276 278,897 474,092 511,678 358,099 390,066 470,616 512,400 9,607 884,705 901,538 814,060 743,109 898,063  1,052,374  
      in-process research and development charge
                                                                               11,887,807  11,887,807 
      impairment of intangible assets
                                                                               1,248,230  1,248,230 
      loss on disposition of intangible assets
                                                                               1,213,878  1,213,878 
      total operating expenses
                                                              261,843 322,906 566,085 446,569 515,631 525,091 529,445 341,321 395,640 477,260 557,336 -52,253 1,383,558 1,467,266 1,614,131 1,918,756 2,707,021 45,141,536 4,924,008 45,141,536 
      equity in losses of hedrin jv
                                                                     162,952 105,362 95,900 135,786          
      change in fair value of derivative liability
                                                              -2,100,898 2,231,746 -170,435 -674,225 -830,165                
      interest and other income
                                                              -196 -323 -143 -320,140 -76,275 -76,716 -75,314 -334,197 -63,873 -61,900 -126,728 -123,021 -148,184 -132,772 -54,657 -14,583 -37,600 -740,106 -29,608 -740,106 
      loss on early extinguishment of debt
                                                              1,225,912     159,070               
      realized gain on sale of marketable equity securities
                                                                               -76,032  -76,032 
      preferred stock dividends
                                                                               -1,179,644  -1,179,644 
      net income applicable to common shares
                                                              -551,739 -2,982,539 3,832,383 365,231 41,247 1,850,336    -1,392,437        -45,531,075  -45,531,075 
      net income per common share:
                                                                                  
      basic and diluted
                                                              -0.16 -1.15 0.03   0.02    -0.02           
      weighted-average shares of common stock outstanding:
                                                                                  
      basic and diluted
                                                              3,431,031 2,595,866 127,439,132 111,875,910      70,624,232           
      gain on nordic settlement
                                                                -4,517,488                  
      weighted average shares of common stock outstanding:
                                                                                  
      basic and diluted
                                                                  120,965,244 120,429,688 84,638,502 70,624,232 70,624,232  70,624,232 70,624,232 70,624,232 70,624,232 70,624,232 68,015,075 70,591,623  70,463,543  
      change in fair value of derivative
                                                                   -2,808,996 942,261 -98,824 -157,778 746,667 70,000          
      net loss applicable to common shares
                                                                    -1,633,169 -222,913 -416,089  -761,844 127,019 -1,394,316 -1,422,212 -1,559,474 -1,904,174 -2,669,421  -4,894,400  
      net loss per common share:
                                                                                  
      basic and diluted
                                                                    -0.02  -0.01  -0.01  -0.02 -0.02 -0.02 -0.03 -0.04  -0.07  
      equity in loss of hedrin jv
                                                                         61,932.75 140,138 87,718       
      (including stock based compensation expense of
                                                                                  
      102,739, 98,302 and 631,462 for the three months
                                                                                  
      ended march 31, 2007, march 31, 2006 and for the
                                                                                  
      cumulative period from august 6, 2001 (inception) to
                                                                                  
      march 31, 2007, respectively)
                                                                               19,632,804  19,632,804 
      232,471, 213,610 and 1,379,247 for the three months
                                                                                  
      see accompanying notes to unaudited condensed consolidated financial statements.
                                                                                  
                                                                                  
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-05-10 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-09-30 2011-06-30 2011-03-31 2010-09-30 2010-06-30 2010-03-31 2008-09-30 2008-06-30 2008-03-31 2007-12-31 2007-09-30 2007-06-30 2007-03-31 
                                                                             
        assets
                                                                             
        current assets:
                                                                             
        cash and cash equivalents
      442,209,000 79,148,000 74,081,000 129,126,000 132,139,000 179,894,000 195,822,000 82,910,000 75,477,000 92,933,000 150,902,000 97,009,000 61,469,000 102,304,000 109,860,000 147,073,000 185,676,000 298,887,000 326,512,000 401,707,000 471,514,000 553,439,000 254,154,000 260,512,000 52,051,000 112,637,000 44,675,000 57,228,000 64,349,000 64,349,000 41,958,000 70,718,000 105,672,000 82,896,000 56,717,847 91,842,167 77,602,363 95,637,572 25,031,280 29,156,521 28,577,832 36,478,420 55,061,329 65,461,940 60,300,086 86,004,445 55,713,784 53,225,799 37,077,977 49,596,327 40,485,466 50,183,397 13,416,952 15,188,167 16,455,995 17,373,866 20,367,079 20,923,750 212,280 492,508 591,316 1,075,966 1,572,031 2,017,280 35,664 576,354 1,133,124 649,686 2,032,655 4,790,589 8,689,792 
        short-term investment securities
      72,221,000 62,822,000 57,501,000 122,744,000 144,101,000 131,106,000 145,219,000 134,342,000 134,308,000 124,575,000 78,257,000 47,896,000 78,241,000 59,374,000 66,082,000 48,636,000 47,525,000 15,876,000 30,338,000 41,752,000 52,334,000 51,987,000  15,058,000 26,284,000 27,798,000 27,776,000 27,748,000 28,125,000 28,125,000 26,848,000 27,024,000 20,573,000 26,181,000 27,998,810  8,808,930 13,823,332 19,853,860 31,445,616 25,680,319 22,224,258 22,166,512 28,701,209 31,765,910 19,131,437 23,062,034 14,009,644 7,959,652 3,901,783                      
        accounts receivable
      392,046,000 305,628,000 265,384,000 231,516,000 190,121,000 129,185,000 115,727,000 83,608,000 64,982,000 51,093,000 39,320,000 17,484,000 8,623,000   88,000 903,000 1,389,000 1,384,000 931,000 771,000                                                   
        inventories
      129,029,000 125,586,000 146,953,000 155,202,000 157,759,000 110,458,000 84,669,000 81,243,000 77,719,000 39,823,000 33,553,000 30,234,000 27,221,000                                                           
        other current assets
      51,464,000 57,580,000 55,846,000 25,374,000 20,390,000 15,716,000 32,632,000   5,336,000 12,081,000 11,088,000 4,458,000 2,359,000 2,954,000 3,136,000 4,020,000 2,884,000 2,502,000 2,950,000 4,804,000 1,083,000 641,000 1,536,000 1,944,000 611,000 864,000 987,000 1,464,000 1,464,000 439,000 526,000 816,000 978,000 436,789 796,283 927,657 1,057,715 216,397 500,564 649,738 730,523 308,327 457,918 548,776 701,862 173,952 258,721 197,855 359,885 47,804 118,437 136,712 225,440 29,128 64,652 89,488 79,030 100,759 116,826 65,807 147,435 157,706 119,704        
        total current assets
      1,086,969,000 630,764,000 599,765,000 663,962,000 644,510,000 566,359,000 574,069,000 389,150,000 360,581,000 317,943,000 319,114,000 208,574,000 184,783,000 168,274,000 182,922,000 202,560,000 242,216,000 330,965,000 371,779,000 455,068,000 535,013,000 611,740,000 260,335,000 280,938,000 88,016,000 149,151,000 80,355,000 94,441,000 105,058,000 105,058,000 79,031,000 109,737,000 136,038,000 116,958,000 93,317,400 97,661,296 97,044,477 118,963,818 50,864,144 71,332,374 69,551,680 70,576,744 86,873,331 104,730,487 103,727,043 115,738,341 85,215,029 76,665,848 49,286,908 56,288,114 42,303,263 50,613,334 14,168,995 17,788,745 18,475,882 19,158,346 20,456,567 21,002,780 313,039 609,334 901,602 1,267,661 1,826,233 2,285,717 111,086 711,894 1,366,669 865,538 2,234,816 5,143,246 9,191,884 
        restricted cash
      1,352,000 1,342,000 1,329,000 1,316,000 1,302,000 1,298,000 1,295,000 1,292,000 1,289,000 1,285,000 1,282,000 1,279,000 1,276,000 1,273,000 1,269,000 1,266,000 1,265,000 1,264,000 1,263,000 1,261,000 1,260,000 1,259,000 1,257,000 1,255,000 1,252,000 1,251,000 1,248,000 1,246,000 1,244,000 1,244,000 1,241,000 1,239,000 1,237,000 588,000 587,291 586,259 585,229 584,213 583,208 582,184 581,161 580,151 579,143 578,126 577,110 576,072 575,012                         
        long-term investment securities
      61,538,000 59,136,000 48,757,000 28,590,000 1,907,000 808,000 1,125,000 947,000 1,320,000     12,404,000 21,766,000 36,078,000 47,472,000 35,533,000 24,550,000 12,757,000                     21,435,015 26,458,226 25,003,032 21,088,192 18,311,340    6,110,309 1,001,858 4,918,897                     
        right of use assets
      6,481,000 6,278,000 6,501,000 6,718,000 6,927,000 7,151,000 7,411,000 7,663,000 7,906,000 8,050,000 8,271,000 8,475,000 8,689,000 8,888,000 9,079,000 8,783,000 8,964,000 8,629,000 8,804,000 8,973,000 9,141,000 9,312,000                                                  
        deferred tax assets
      344,136,000 348,000,000 366,627,000                                                                     
        non-current inventories
      26,346,000                                                                       
        other noncurrent assets
      2,015,000 2,044,000 2,045,000 2,027,000 2,042,000 2,074,000 2,114,000 2,155,000                                                                
        total assets
      1,528,837,000 1,063,253,000 1,025,024,000 702,613,000 656,689,000 577,690,000 586,014,000 401,207,000 373,323,000 329,587,000 331,067,000 220,854,000 197,358,000 193,572,000 217,891,000 251,666,000 303,028,000 379,629,000 409,687,000 481,400,000 548,699,000 625,642,000 273,856,000 294,621,000 101,849,000 163,014,000 93,327,000 106,585,000 117,538,000 117,538,000 83,616,000 114,374,000 140,715,000 120,994,000 97,381,536 101,781,514 101,197,751 123,256,432 54,781,547 75,687,094 94,797,540 100,062,519 113,473,201 127,407,138 123,605,281 117,269,251 86,746,890 77,544,253 56,302,299 58,173,955 48,112,390 54,299,275 17,858,571 21,386,785 22,074,037 25,231,218 26,529,557 27,074,371 18,064,479 18,361,010 18,653,689 19,034,882 19,593,714 20,081,864 204,900 973,340 1,487,416 980,577 2,357,794 5,276,656 9,336,522 
        liabilities and stockholders’ equity
                                                                             
        current liabilities:
                                                                             
        accounts payable and accrued expenses
      148,845,000 107,508,000 112,336,000 134,021,000 133,932,000 58,296,000 101,407,000 93,472,000 87,266,000 38,471,000 39,741,000 62,945,000 57,092,000 42,019,000 29,726,000 37,224,000 49,668,000 51,294,000 44,702,000 40,228,000 42,837,000 37,014,000 34,659,000 29,670,000 30,903,000 30,041,000 31,780,000 31,498,000 40,199,000 40,199,000 36,377,000 37,917,000 35,394,000 32,513,000 25,877,218 18,179,772 19,556,942 18,916,064 15,267,668 15,550,129 13,080,176 8,139,440 9,346,068 8,583,003 8,254,189 8,880,438 3,991,625 7,967,548 1,899,389 1,639,114 4,764,502 4,325,313 2,247,518 1,387,882 1,117,397   467,524 167,719 207,649 183,280 395,817 373,795 302,728        
        other current liabilities
      596,000 2,124,000 1,993,000 2,256,000 2,947,000 4,627,000 3,298,000 4,162,000 4,064,000 1,631,000 1,217,000 1,569,000 1,221,000 1,169,000 807,000 1,740,000 1,873,000 1,512,000 12,628,000 14,151,000 14,460,000 18,236,000 21,735,000 25,572,000 29,245,000 48,994,000 44,035,000 21,478,000 18,626,000 18,626,000                                          
        lease liability – current portion
      1,822,000 1,044,000 1,068,000 1,091,000 1,116,000 1,157,000 1,231,000 1,306,000 1,383,000 1,446,000 1,479,000 1,512,000 1,546,000 1,581,000 1,616,000 1,480,000 1,492,000 1,437,000 1,468,000 1,500,000 1,533,000 1,669,000 1,614,000 1,655,000 1,602,000 1,616,000 1,365,000 1,283,000 1,261,000 1,261,000                                          
        deferred revenue - current portion
      17,190,000 21,234,000 26,399,000 23,911,000 17,079,000 11,414,000 9,093,000 3,373,000 3,373,000  6,903,000                                                             
        accrued compensation
      18,655,000 21,850,000 15,014,000 10,610,000 5,135,000 15,185,000 10,085,000 6,351,000 3,598,000 12,172,000 8,338,000 6,641,000 3,217,000 8,432,000 4,298,000 2,882,000 1,623,000 10,166,000 12,858,000 8,514,000 3,537,000 8,456,000 5,072,000 3,440,000 1,368,000 3,798,000 3,017,000 1,708,000 854,000 854,000 2,258,000 2,082,000 1,182,000 456,000 1,800,000 1,275,305 896,805 483,555 1,389,516 1,061,626 796,376 449,126 818,472 768,750 506,000 248,000 702,000 599,083 395,500 197,250 532,500 350,000 232,750 115,500 145,000                 
        total current liabilities
      187,108,000 153,760,000 156,810,000 171,889,000 160,209,000 90,679,000 125,114,000 108,664,000 99,684,000 53,720,000 57,678,000 72,667,000 63,076,000 53,201,000 36,447,000 43,326,000 54,656,000 65,384,000 87,655,000 87,551,000 92,494,000 87,554,000 77,670,000 67,537,000 63,118,000 84,449,000 80,197,000 55,967,000 60,940,000 60,940,000 38,854,000 40,242,000 36,938,000 33,345,000 27,957,213 19,789,614 20,758,696 19,726,657 16,878,440 16,881,262 14,119,497 8,893,864 10,528,470 9,685,802 9,207,930 9,553,025 5,121,196 8,902,156 2,606,484 1,988,745 6,317,178 5,678,223 3,466,256 2,472,962 2,216,067 2,957,518 2,349,047 1,222,095 1,515,086 3,782,728 3,351,788 4,207,716 4,928,252 7,202,959 2,013,626 1,467,092   1,791,146   
        deferred revenue, non-current portion
      6,863,000 8,807,000 8,348,000 1,667,000 6,598,000 12,085,000 16,166,000 3,743,000 3,244,000  190,000                                                             
        loan payable – non-current
      745,140,000 245,645,000 245,340,000 245,037,000 244,733,000  244,158,000 102,537,000 101,326,000  98,908,000 97,700,000 96,503,000 71,135,000 70,038,000 68,947,000 67,249,000 66,788,000                                                      
        lease liability – non-current
      6,595,000 7,021,000 7,308,000 7,588,000 7,860,000 8,133,000 8,419,000 8,695,000 8,960,000 9,231,000 9,522,000 9,805,000 10,079,000 10,344,000 10,582,000 9,977,000 10,318,000 9,847,000 10,020,000 10,186,000 10,349,000 10,412,000 9,806,000 9,938,000 10,159,000                                               
        total liabilities
      945,706,000 415,233,000 417,806,000 426,181,000 419,400,000 355,326,000 393,857,000 223,639,000 213,214,000 169,085,000 166,298,000 180,401,000 169,925,000 134,985,000 117,410,000 122,631,000 132,642,000 142,476,000 98,170,000 98,270,000 103,414,000 106,292,000 103,198,000 100,394,000 103,202,000 124,399,000 119,118,000 93,380,000 98,284,000 98,284,000 59,580,000 42,630,000 39,339,000 35,762,000 30,388,481 22,235,748 23,222,733 22,214,673 18,913,745 18,932,373 16,096,455 10,616,751 11,899,899 11,095,326 10,655,549 11,038,739 6,645,006 10,464,061 4,206,484 3,742,394 8,057,898 9,661,555 7,583,453 6,687,698 6,523,736 7,337,918 6,744,147 5,886,792 18,359,097 20,510,557 19,956,829 24,770,122 25,375,831 27,599,378 4,962,802 4,420,322 1,786,438 1,871,662  2,530,255 2,192,910 
        commitments and contingencies
                                                                             
        stockholders’ equity:
                                                                             
        common stock, 0.001 par value per share...
      160,000 159,000 159,000 159,000 159,000 156,000 156,000 155,000 155,000 151,000 151,000 151,000 149,000 146,000 145,000 145,000 145,000 143,000 143,000 143,000 142,000 141,000 129,000 127,000 110,000 109,000 97,000 93,000 89,000 89,000 84,000 83,000 82,000 77,000 73,182 70,694 68,127 66,817 56,820 54,766 54,498 54,119 54,095 52,558 51,698 47,472 44,974 41,481 38,162 37,526 34,336 33,414 26,735 26,323 25,821 20,059 18,054 5,061              
        additional paid-in capital
      1,845,435,000 1,830,110,000 1,812,345,000 1,794,212,000 1,776,381,000 1,760,396,000 1,746,909,000 1,734,052,000 1,685,256,000 1,674,946,000 1,664,797,000 1,654,411,000 1,593,783,000 1,585,708,000 1,574,609,000 1,567,345,000 1,568,186,000 1,565,942,000 1,546,967,000 1,532,943,000 1,516,602,000 1,500,040,000 1,063,142,000 999,549,000 751,103,000 739,956,000 635,989,000 613,059,000 582,900,000 582,900,000 552,531,000 546,380,000 542,062,000 481,781,000 422,017,042 403,712,474 370,608,641 365,323,608 272,432,139 269,646,963 266,762,568 261,608,568 259,887,464 257,015,699 239,998,563 216,180,386 175,476,521 143,661,893 111,229,666 101,579,618 79,658,490 78,428,989 39,516,871 37,356,700 34,534,805 24,817,526 24,001,440 22,841,334 60,693,779 58,291,913 56,028,583 55,802,925 55,797,295 55,919,120 54,566,421 54,483,025 56,188,898 54,037,361 53,590,920 53,101,402 52,604,353 
        treasury stock
      -200,226,000 -100,234,000 -100,234,000 -21,992,000 -15,117,000 -8,994,000 -2,383,000 -234,000 -234,000 -234,000 -234,000 -234,000 -234,000 -234,000 -234,000 -234,000 -234,000 -234,000 -234,000 -234,000 -234,000 -234,000 -234,000 -234,000 -234,000 -234,000 -234,000 -234,000 -234,000 -234,000 -234,000 -234,000 -234,000 -234,000 -234,337 -234,337 -234,337 -234,337 -234,337 -234,337 -234,337 -234,337 -234,337 -234,337 -234,337 -234,337 -234,337 -234,337 -234,337 -234,337 -234,337 -84,538 -84,538 -84,538 -84,538                 
        accumulated deficit
      -1,062,238,000 -1,082,015,000 -1,105,052,000 -1,495,947,000 -1,524,134,000 -1,529,194,000 -1,552,525,000 -1,556,405,000 -1,525,068,000 -1,514,361,000 -1,499,945,000 -1,613,875,000 -1,566,265,000 -1,527,033,000 -1,474,039,000 -1,438,221,000 -1,397,711,000 -1,328,698,000 -1,235,359,000 -1,149,722,000 -1,071,225,000 -980,597,000 -892,379,000 -805,215,000 -752,332,000 -701,216,000 -661,643,000 -599,713,000 -563,501,000 -563,501,000 -528,345,000 -474,485,000 -440,534,000 -396,392,000 -354,862,832 -324,003,065 -292,467,413 -264,114,329 -236,386,820 -212,712,677 -187,881,650 -171,982,588 -158,133,926 -140,522,114 -126,866,198 -109,763,015 -95,185,280 -76,388,851 -58,937,682                       
        total stockholders’ equity
      583,131,000 648,020,000 607,218,000 276,432,000 237,289,000 222,364,000 192,157,000 177,568,000 160,109,000 160,502,000 164,769,000 40,453,000 27,433,000 58,587,000 100,481,000 129,035,000 170,386,000 237,153,000 311,517,000 383,130,000 445,285,000 519,350,000 170,658,000 194,227,000  38,615,000  13,205,000 19,254,000 19,254,000 24,036,000 71,744,000 101,376,000 85,232,000 66,993,055 79,545,766 77,975,018 101,041,759 35,867,802 56,754,721 78,701,085 89,445,768 101,573,302 116,311,812                        -891,085 566,648 2,746,401 7,143,612 
        total liabilities and stockholders’ equity
      1,528,837,000 1,063,253,000 1,025,024,000 702,613,000 656,689,000 577,690,000 586,014,000 401,207,000 373,323,000 329,587,000 331,067,000 220,854,000 197,358,000 193,572,000 217,891,000 251,666,000 303,028,000 379,629,000 409,687,000 481,400,000 548,699,000 625,642,000 273,856,000 294,621,000  163,014,000  106,585,000 117,538,000 117,538,000 83,616,000 114,374,000 140,715,000 120,994,000 97,381,536 101,781,514 101,197,751 123,256,432 54,781,547 75,687,094 94,797,540 100,062,519 113,473,201 127,407,138                            
        long-term inventories
       15,689,000                                                                      
        loan payable
           244,429,000    100,118,000                                                              
        prepaid research and development and other current assets
             7,047,000 8,095,000                                                               
        leasehold interest
              1,362,000 1,415,000 1,468,000 1,521,000 1,574,000 1,627,000 1,680,000 1,733,000 1,786,000 1,839,000 1,892,000 1,945,000 1,998,000 2,051,000 2,104,000 2,157,000 2,168,000 2,129,000 2,157,000 2,203,000 2,249,000 2,249,000 2,294,000 2,331,000 2,376,000 2,397,000 2,429,434 2,466,202 2,479,349 2,491,211 2,042,281 2,517,771 1,968,734                               
        equipment
              66,000 95,000 133,000 206,000 237,000 307,000 376,000 447,000 526,000 600,000 600,000 597,000 488,000 481,000 378,000 331,000 320,000 282,000 275,000 237,000 241,000 241,000 251,000 268,000 265,000 252,000 248,020 268,366 289,305 307,732 328,148 327,674     34,833 24,821 20,357 7,763 7,326 8,177 5,718 3,829 2,527 1,049 1,164 1,281 1,399               
        goodwill
              799,000 799,000 799,000 799,000 799,000 799,000 799,000 799,000 799,000 799,000 799,000 799,000 799,000 799,000 799,000 799,000 799,000 799,000 799,000 799,000 799,000 799,000 799,000 799,000 799,000 799,000 799,391 799,391 799,391 799,391 799,391 799,391 799,391 799,391 799,391 799,391 799,391 799,391 799,391 799,391 799,391 799,391 799,391 799,391 799,391 799,391 799,391 629,752 629,752 629,752              
        prepaid research and development
               4,183,000 5,001,000 4,863,000 4,771,000 4,237,000 4,026,000 3,627,000 4,092,000 11,929,000 11,043,000 7,728,000 5,590,000 5,231,000 5,540,000 3,832,000 7,737,000 8,105,000 7,040,000 8,478,000 11,120,000 11,120,000 9,691,000 11,389,000 8,890,000 6,824,000 8,055,486 5,022,846 9,662,237 8,422,375 5,678,755 10,121,215 14,510,025 10,979,437 9,151,142 9,950,893 10,921,958 9,810,887 6,179,743 9,117,863 3,976,742 2,418,995 1,742,824 311,500 615,331 2,375,138 1,990,759 1,719,828                
        deferred revenue
               6,016,000                                                              
        ​
                              2,020,000                                               
        deferred revenue, net of current portion
                 229,000 267,000 305,000 343,000 381,000 419,000 457,000 495,000 533,000 571,000 610,000 648,000 686,000 724,000 762,000 800,000 838,000 876,000 876,000 914,000 952,000 990,000 1,029,000 1,066,667 1,104,762 1,142,857 1,180,953 1,219,048 1,257,143 1,295,238 1,333,333 1,371,429 1,409,524 1,447,619 1,485,714 1,523,810 1,561,905 1,600,000 1,638,095 1,676,191 1,714,286 1,752,381 1,790,476 1,828,571                 
        loan payable – current portion
                       975,000 15,999,000 23,158,000 30,127,000 22,179,000 14,590,000 7,200,000                                                
        preferred stock, 0.001 par value per share...
                                                               1,109              
        long-term debt
                           7,716,000 15,074,000 22,233,000 29,201,000 28,970,000 28,741,000 28,513,000 28,286,000 28,286,000                                          
        right-of-use-assets
                            8,983,000 9,141,000                                                
        right of use asset
                              9,294,000 9,402,000 8,493,000 7,659,000 7,947,000 7,947,000                                          
        liabilities and stockholders’ (deficit) equity
                                                                             
        stockholders’ (deficit) equity:
                                                                             
        total stockholders’ (deficit) equity
                              -1,353,000  -25,791,000                                             
        total liabilities and stockholders’ (deficit) equity
                              101,849,000  93,327,000                                             
        license revenue
                              38,000  38,000                                             
        costs and expenses:
                                                                             
        research and development:
                                                                             
        noncash compensation
                              1,979,000  1,482,000                                             
        other research and development
                              34,043,000  56,503,000                                             
        total research and development
                              36,022,000  57,985,000                                             
        general and administrative:
                                                                             
        other general and administrative
                              5,172,000  2,321,000                                             
        total general and administrative
                              14,261,000  2,914,000                                             
        total costs and expenses
                              50,283,000  60,899,000                                             
        operating income
                              -50,245,000  -60,861,000                                -261,843 -322,906 -566,085 -515,631 -525,091 -529,445  -1,467,266      
        other income:
                                                                             
        interest expense
                              1,201,000  1,537,000                                1,165,078 428,210 289,598 349,562 351,215 236,777        
        other income
                              -330,000  -468,000                                             
        total other income
                              871,000  1,069,000                                289,896 2,659,633 -4,398,468 -556,878 -2,375,427 1,103,724  -45,054      
        net income
                              -51,116,000  -61,930,000                                -551,739 -2,982,539 3,832,383 41,247 1,850,336 -1,633,169  -1,422,212      
        basic and diluted net income per common share
                              -480  -690                                             
        weighted-average shares used for eps calculation
                              105,461,892,000  89,667,979,000                                             
        deferred rent
                                    1,462,000 1,436,000 1,411,000 1,388,000 1,364,601 1,341,372 1,321,180 1,307,063 816,257 793,968 681,720 389,554                              
        lease liability – non current
                               10,218,000 9,380,000 8,062,000 8,182,000 8,182,000                                          
        long-term liabilities
                                    18,350,000                                         
        noncash stock expense associated with in–licensing agreements
                                                                             
        interest receivable
                                    95,000 80,000 87,000 79,000 108,468  43,290 22,824 83,852 108,458 133,766 164,106 186,021 158,527 190,313 89,710 85,516 53,821 74,682 11,124 27,169                     
        current portion of deferred revenue
                                    152,000 152,000 152,000 152,000 152,381 152,381 152,381 152,381 152,381 152,381 152,381 152,381 152,381 152,381 152,381 152,381 152,381 152,381 152,381 152,381 152,381 152,381 152,381 152,381 152,381                 
        notes payable
                                    67,000 91,000 210,000 224,000 127,614 182,156 152,568 174,657 68,875 117,126 90,564 152,917 211,549 181,668 295,360                           
        other assets
                                           110,067 164,375 127,700 127,700 173,841 171,182 141,717 155,564 130,626 137,101 71,251 98,365 76,415 85,121 85,121 90,058      7,750 7,750 7,750 21,370 21,370 21,370 79,625 84,126 84,126 70,506 70,506 70,506 70,506 
        contingently issuable shares
                                             15,890 15,890 15,890 15,890 15,890 15,890        
        property, plant and equipment
                                              333,859 323,003 47,122 69,225                            
        prepaid rent
                                               1,151,163                              
        4
                                                                             
        liabilities and equity
                                                                             
        equity:
                                                                             
        total equity
                                                  112,949,732 106,230,512 80,101,884 67,080,192 52,095,815 54,431,561 40,054,492 44,637,720 10,275,118 14,699,087 15,550,301 17,893,300 19,785,410 21,187,579              
        total liabilities and equity
                                                  123,605,281 117,269,251 86,746,890 77,544,253 56,302,299 58,173,955 48,112,390 54,299,275 17,858,571 21,386,785 22,074,037 25,231,218 26,529,557 27,074,371              
        notes payable, current portion
                                                   272,206 275,190 183,144 159,214  677,778 677,778 677,778 677,778 677,778 677,778 677,778 677,778   2,309,647 2,036,645 2,012,720         
        interest payable
                                                        190,017 172,751 155,829 139,421                  
        notes payable, less current portion, at fair value
                                                       115,554 64,529 2,269,046 2,364,816 2,424,260 2,479,098                 
        deficit accumulated in the development stage
                                                       -46,951,252 -39,404,003   -22,599,404 -18,925,793                 
        in-process research and development
                                                         2,797,600 2,797,600 2,797,600 2,797,600 5,441,839 5,441,839 5,441,839 17,742,110 17,742,110 17,742,110 17,742,110 17,742,110 17,742,110        
        deficit accumulated in development stage
                                                         -33,740,151 -29,183,956   -15,466,056 -13,003,817 -11,109,164              
        interest payable, current portion
                                                            123,511 107,569 91,944 76,793   565,879 415,256 351,574 290,439        
        total stockholder’s equity
                                                            15,550,301                 
        non-controlling interest in subsidiary
                                                               9,449,233              
        accounts payable - related party
                                                             1,799,424 1,257,600               
        other accounts payable and accrued expenses
                                                             372,747 321,725               
        notes payable, noncurrent portion, at fair value
                                                             4,380,400 4,395,100 4,664,697              
        tg therapeutics, inc. and subsidiaries:
                                                                             
        total tg therapeutics, inc. and subsidiaries equity
                                                             9,371,535 11,015,683 11,738,346              
        noncontrolling interest in subsidiary
                                                             8,521,765 8,769,727               
        tg therapeutics, inc. and subsidiaries
                                                                             
        grant receivable
                                                                  244,479           
        debt issue costs
                                                                     29,922        
        property and equipment
                                                                1,580 1,816 2,227 3,741 4,001 2,745 11,920 34,912 36,621 44,533 52,472 62,904 74,132 
        liabilities and stockholders' deficiency
                                                                             
        notes payable, current portion, net of discount
                                                                761,314 775,290            
        interest payable, current portion, net of beneficial conversion
                                                                47,223 160,061            
        derivative liability
                                                                538,830 2,639,728 292,982 1,359,998 2,190,163 4,620,998        
        notes payable, noncurrent portion, net of discount
                                                                16,388,797 16,475,433            
        interest payable, noncurrent portion
                                                                455,214 252,396 49,578 433,537 240,377         
        exchange obligation
                                                                   3,949,176 3,949,176 3,949,176 2,949,176 2,953,230      
        stockholders’ deficiency:
                                                                             
        preferred stock, .001 par value. authorized 1,500,000 shares; no shares issued and outstanding at september 30, 2011 and december 31, 2010
                                                                             
        common stock
                                                                7,398 2,596 129,794 120,966 120,966 114,080  70,624  70,624 70,624 70,474  
        deficit accumulated during the development stage
                                                                -61,011,685 -60,459,946 -57,477,407 -61,675,021 -61,716,268 -63,566,604 -59,394,947 -58,000,631 -56,558,544 -54,999,070 -53,094,896 -50,425,475 -45,531,075 
        total stockholders’ deficiency
                                                                -294,618 -2,149,547 -1,303,140 -5,735,240 -5,782,117 -7,517,514 -4,757,902 -3,446,982 -299,022     
        total liabilities and stockholders' deficiency
                                                                18,064,479 18,361,010 18,653,689 19,034,882 19,593,714 20,081,864 204,900 973,340 1,487,416     
        revenue
                                                                             
        research and development
                                                                95,897 90,218 355,177 236,734 50,999 17,767  565,728      
        general and administrative
                                                                165,946 232,688 210,908 278,897 474,092 511,678  901,538      
        in-process research and development charge
                                                                             
        impairment of intangible assets
                                                                             
        loss on disposition of intangible assets
                                                                             
        total operating expenses
                                                                261,843 322,906 566,085 515,631 525,091 529,445  1,467,266      
        equity in losses of hedrin jv
                                                                             
        change in fair value of derivative liability
                                                                -2,100,898 2,231,746 -170,435 -830,165          
        interest and other income
                                                                -196 -323 -143 -76,275 -76,716 -75,314  -132,772      
        loss on early extinguishment of debt
                                                                1,225,912    159,070         
        realized gain on sale of marketable equity securities
                                                                             
        preferred stock dividends
                                                                             
        net income applicable to common shares
                                                                -551,739 -2,982,539 3,832,383 41,247 1,850,336 -1,633,169  -1,422,212      
        net income per common share:
                                                                             
        basic and diluted
                                                                -0.16 -1.15 0.03 120,965,244 0.02 -0.02  -0.02      
        weighted-average shares of common stock outstanding:
                                                                             
        preferred stock, .001 par value. authorized 1,500,000 shares; no shares issued and outstanding at june 30, 2011 and december 31, 2010
                                                                             
        gain on nordic settlement
                                                                  -4,517,488           
        notes payable, noncurrent portion
                                                                  16,555,463 16,179,693 16,258,026         
        preferred stock, .001 par value. authorized 1,500,000 shares; no shares issued and outstanding at march 31, 2011 and december 31, 2010
                                                                             
        debt issue costs, current portion
                                                                   44,260 96,496 148,733        
        preferred stock, .001 par value. authorized 1,500,000 shares; no shares issued and outstanding at september 30, 2010 and december 31, 2009
                                                                             
        preferred stock, .001 par value. authorized 1,500,000 shares; no shares issued and outstanding at june 30, 2010 and december 31, 2009
                                                                             
        change in fair value of derivative
                                                                    -2,808,996 942,261        
        secured 12% notes payable, current portion
                                                                     1,655,461        
        8% note payable
                                                                             
        icon note payable, current portion
                                                                     333,333        
        convertible 5% notes payable
                                                                     15,452,793        
        secured 12% notes payable, non-current portion
                                                                             
        convertible 12% note payable
                                                                     42,466        
        icon convertible note payable, non-current portion
                                                                     666,667        
        non-interest bearing note payable
                                                                     216,900        
        interest payable, non-current portion
                                                                     68,417        
        preferred stock, .001 par value. authorized 1,500,000 shares; no shares issued and outstanding at march 31, 2010 and december 31, 2009
                                                                             
        prepaid expenses and other current assets
                                                                      75,422 135,540      
        investment in hedrin jv
                                                                      2,269 142,408      
        liabilities and stockholders’ deficiency
                                                                             
        secured 10% notes payable
                                                                      70,000       
        accounts payable
                                                                      705,323 617,346 986,223 1,279,485 852,490 1,001,849 1,523,663 
        accrued expenses
                                                                      1,238,303 849,746 800,215 592,177 938,656 1,528,406 669,247 
        preferred stock, .001 par value. authorized 1,500,000 shares; no shares issued
                                                                             
        and outstanding at september 30, 2008 and december 31, 2007
                                                                             
        shares issued and outstanding at september 30, 2008 and december 31, 2007
                                                                      70,624       
        see accompanying notes to condensed consolidated financial statements.
                                                                             
        preferred stock, .001 par value. authorized 1,500,000 shares; no shares issued and outstanding at june 30, 2008 and december 31, 2007
                                                                             
        equity in loss of hedrin jv
                                                                       87,718      
        prepaid expenses
                                                                        233,545 215,852 202,161 352,657 252,092 
        and outstanding at march 31, 2008 and december 31, 2007
                                                                             
        shares issued and outstanding at march 31, 2008 and december 31, 2007
                                                                        70,624     
        stockholders’ equity
                                                                             
        preferred stock, .001 par value. authorized 1,500,000 shares; no shares issued and outstanding at december 31, 2007 and 2006
                                                                             
        total liabilities and stockholders' equity
                                                                         980,577 2,357,794 5,276,656 9,336,522 
        preferred stock, .001 par value. authorized 1,500,000 shares; no shares issued and outstanding at september 30, 2007 and december 31, 2006, respectively
                                                                             
        preferred stock, .001 par value. authorized 1,500,000 shares; no shares issued and outstanding at june 30, 2007 and december 31, 2006
                                                                             
        subscription receivable
                                                                            250,000 
        preferred stock, .001 par value. authorized 1,500,000 shares;
                                                                             
        no shares issued and outstanidng at march 31, 2007
                                                                             
        and december 31, 2006, respectively
                                                                             
        70,333,316 and 60,120,038 shares issued and outstanding
                                                                             
        at march 31, 2007 and december 31, 2006, respectively
                                                                            70,334 
        see accompanying notes to unaudited condensed consolidated financial statements.
                                                                             
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-05-10 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-06-30 2010-03-31 2009-12-31 2009-09-30 2009-06-30 2009-03-31 2008-12-31 2008-09-30 2008-06-30 2008-03-31 2007-12-31 2007-09-30 2007-08-06 2007-03-31 
                                                                                    
          cash flows from operating activities
                                                                                    
          net income
        19,777,000 23,037,000 390,895,000 28,187,000 5,060,000 23,331,000    -14,416,000                    -35,156,000                             -551,739 -2,982,539 3,832,383 365,231     -1,392,439 -761,844         
          adjustments to reconcile net loss to net cash from operating activities:
                                                                                    
          loss on extinguishment of debt
        9,153,000                                                                           
          stock-based compensation
        19,950,000                                                                            
          depreciation and amortization
        32,000 21,000 17,000 13,000 8,000 9,000 11,000 19,000 29,000 38,000 73,000 32,000 68,000 73,000 76,000 78,000 76,000 80,000 76,000 67,000 59,000 53,000 41,000 34,000 30,000                                                    
          amortization of premium (discount) on investment securities
        -367,000  -786,000 -1,283,000 -1,336,000  -1,817,000 -1,800,000 -1,670,000 -1,532,000 -217,000 -186,000 -301,000 -159,000                                                               
          amortization of debt issuance costs
        285,000 304,000 304,000 304,000 304,000 303,000 414,000 639,000 639,000 639,000 639,000 639,000 461,000 461,000 461,000 461,000 461,000 386,000 231,000 232,000 231,000 231,000 231,000 232,000 231,000 233,000 231,000 231,000 77,000 77,000                                               
          amortization of leasehold interest
        48,000 46,000 45,000 46,000 48,000 53,000 53,000 53,000 53,000 53,000 53,000 53,000 53,000 53,000 53,000 53,000 53,000 53,000 53,000 53,000 53,000 53,000 53,000 56,000 54,000 45,000                                                   
          deferred income taxes
        3,864,000 18,627,000                                                                           
          noncash change in lease liability and right of use asset
        573,000 432,000 431,000 432,000 453,000 498,000 497,000 498,000 407,000 490,000 483,000 499,000 491,000 510,000 1,191,000 331,000 683,000 474,000 473,000 470,000 479,000                                                        
          change in fair value of equity investments
        -1,534,000 433,000 -420,000 181,000 104,000 501,000 75,000 373,000 -195,000                                                                    
          change in fair value of notes payable
        88,000 -136,000 14,000 -64,000 213,000 153,000 127,000 59,000 -35,000 184,000 -332,000 202,000 59,000 125,000 35,000 -98,000 -178,000 -263,000 -94,000 -163,000 -58,000 462,000 134,000 172,000 -20,000       -119,000    29,588     -31,752 -58,632 36,805 -113,692 23,154 -2,984 92,046 23,930    -95,770                         
          changes in assets and liabilities:
                                                                                    
          increase in inventory
        -13,275,000 563,000 8,695,000 3,595,000 -46,305,000 -24,820,000 -2,540,000 -2,560,000 -36,931,000   -1,972,000 -26,924,000                                                                
          decrease in other current assets
        10,661,000   -5,260,000 -4,627,000   1,050,000 1,490,000 7,534,000 -1,049,000 -6,693,000 -2,623,000 339,000 -212,000 1,295,000 6,759,000 -1,253,000 -2,834,000   -135,000 -813,000        1,783,000    -2,813,048            3,022,889 -5,201,987   -1,360,692 322,107 1,848,534 -580,691   -10,460 8,147                   
          increase in accounts receivable
        -86,418,000 -40,244,000 -33,868,000 -41,395,000 -60,936,000  -32,119,000 -18,626,000 -13,889,000         -5,000 -453,000 -160,000 -771,000                                                        
          increase in income taxes payable
        -6,718,000                                                                            
          increase in accounts payable and accrued expenses
        34,016,000 2,008,000 -17,280,000 5,565,000 65,585,000 -38,012,000 11,669,000 8,959,000 40,222,000   9,278,000 9,858,000 16,426,000 -6,081,000 -11,185,000 -10,170,000 3,901,000 8,819,000 2,367,000 904,000 5,738,000   -1,567,000 -958,000   2,240,000 2,240,000 -1,364,000 3,423,000 3,606,000 5,292,000 8,353,870 -401,751 516,189 2,551,726 45,429 2,735,203 5,287,986 -1,575,974 812,787 639,361 -416,046 4,434,813 -3,873,006 6,271,742 886,340 -3,888,453 621,689 2,195,045 976,886 240,985    -254,604                   
          decrease in lease liabilities
        -424,000 -519,000 -519,000 -518,000 -543,000 -598,000 -597,000 -597,000 -596,000 -595,000 -593,000 -594,000 -593,000 -591,000 -746,000 -503,000 -492,000 -505,000 -501,000 -499,000 -507,000  1,076,000 -469,000 -1,967,000                                                    
          decrease in other current liabilities
        -1,617,000                            -559,000 -559,000                                               
          increase in deferred revenue
        -5,988,000 -4,706,000 9,169,000 1,787,000 140,000 -1,761,000 18,144,000 498,000 602,000 -926,000                                        -38,095 -38,095 -38,096 -38,095 -38,095                       
          net cash from operating activities
        -17,894,000 19,660,000 -23,153,000 7,436,000 -28,715,000 -25,641,000 -12,205,000 5,536,000 -8,207,000 -13,210,000 83,704,000 -42,005,000 -59,902,000 -23,870,000 -34,495,000 -49,116,000 -68,689,000 -86,909,000 -67,201,000 -60,169,000 -81,355,000 -52,026,000 -56,532,000 -43,834,000 -62,115,000 -30,393,000   -33,351,000 -33,351,000 -33,690,000 -33,009,000 -34,183,000 -28,043,000 -21,855,129 -22,776,473 -26,829,596 -22,302,364 -17,025,067 -15,042,201 -12,850,521 -16,673,541 -12,900,661 -10,658,732 -12,248,526 -8,882,353 -15,106,938 -8,050,975 -3,573,115 -8,328,891 -4,909,154 -1,153,970 -2,556,359 -2,204,748 -833,332 -2,993,213 -499,785 -861,634 -280,228 -98,808 212,648 -541,743 -410,811 -604,827 -327,147 -140,927 64,072 -645,797 -919,783 -620,256 -1,442,345 -1,461,625 -1,382,970 -2,755,966 -3,909,685 -2,181,090 
          capital expenditures
        -51,000 -67,000 -80,000 -42,000 -25,000 -175,000 -67,000 -155,000 -89,000 -45,000 -68,000 -34,000   -14,000 -14,000 -34,000 -24,000 -20,970 -27,795 -282,261 16,977 -13,397 -6,883 -14,072 -1,333 -3,165 -1,627  -1  -2,868 -6,267 
          free cash flows
        -17,945,000 19,593,000 -23,233,000 7,394,000 -28,740,000 -25,641,000 -12,205,000 5,536,000 -8,207,000 -13,210,000 83,704,000 -42,005,000 -59,902,000 -23,870,000 -34,495,000 -49,116,000 -68,689,000 -86,909,000 -67,201,000 -60,344,000 -81,422,000 -52,181,000 -56,621,000 -43,879,000 -62,183,000 -30,427,000   -33,365,000 -33,365,000 -33,690,000 -33,009,000 -34,217,000 -28,067,000 -21,855,129 -22,776,473 -26,829,596 -22,302,364 -17,046,037 -15,042,201 -12,878,316 -16,955,802 -12,883,684 -10,658,732 -12,261,923 -8,889,236 -15,121,010 -8,052,308 -3,573,115 -8,332,056 -4,909,154 -1,155,597 -2,556,359  -833,332 -2,993,213 -499,785 -861,634 -280,228 -98,808 212,648 -541,743 -410,811 -604,827 -327,147 -140,927 64,072 -645,797 -919,784 -620,256 -1,442,345  -1,382,969 -2,755,966 -3,912,553 -2,187,357 
          cash flows from investing activities
                                                                                    
          proceeds from maturity of held-to-maturity securities
        11,250,000 30,000,000 77,750,000                                                                          
          investment in held-to-maturity securities
        -21,063,000 -45,571,000 -31,307,000 -53,300,000 -92,059,000 -57,891,000 -101,360,000 -69,734,000 -81,531,000 -68,433,000 -56,279,000 -22,168,000 -3,998,000 -31,466,000 -14,921,000 -56,889,000 -12,232,000 -11,802,000 -14,050,000 -17,447,000 -59,921,000 -7,482,000    -8,171,000 -8,171,000 -6,656,000 -17,609,000 -2,781,000 -4,184,000     -4,558,652 -10,641,270 -8,038,515                                  
          purchases of equity investments
                                                                                    
          purchases of property, plant and equipment
        -51,000 -67,000 -80,000 -42,000 -25,000                                   -27,795 -282,261 16,977         -1,627                       
          net cash from investing activities
        -9,864,000 -15,638,000 46,363,000 -3,992,000 -12,934,000 15,788,000 -9,334,000 1,765,000 -9,255,000 -44,755,000 -30,229,000 30,501,000 -6,168,000 16,269,000 -2,990,000 10,379,000 -43,671,000 3,288,000 -631,000 -2,475,000 -514,000 -52,076,000 14,911,000 11,205,000 1,450,000 4,000   -1,135,000 -1,135,000 238,000 -6,435,000 5,585,000 1,792,000 -28,006,270 8,800,000 4,997,773 6,000,000 11,479,030 15,576,260 1,413,553 -1,923,531 2,478,462 76,574 -31,084,022 3,843,117 -9,132,783 -1,333 -9,218,008 -3,165 -4,922,253 -1,627        -2,844 519,365     -1 13,620 -8,972 -13,620 -2,868 -6,267 
          cash flows from financing activities
                                                                                    
          payment of loan payable
        -255,000,000            -975,000 -15,410,000 -7,390,000                                                          
          proceeds from exercise of options
        763,000 1,058,000 432,000 21,000 570,000 199,000 135,000 10,000 420,000 751,000 363,000 49,000 275,000 135,000 125,000 50,000 38,000 128,000 12,000 39,000 15,000 81,000                                                    
          proceeds from debt financings, net of debt discount costs
        747,656,000                                                                            
          financing costs paid
        -2,598,000     -31,000    -125,000             -315,000   -538,000 -538,000                                               
          purchase of treasury stock
        -99,992,000 -78,242,000 -6,875,000 -6,123,000 -6,611,000                                                                       
          net cash from financing activities
        390,829,000 1,058,000 -78,242,000 -6,443,000 -6,102,000 -6,072,000 134,454,000 135,000 10,000 -1,000 421,000 47,047,000 25,238,000 49,000 275,000 135,000 -850,000 55,997,000 -7,361,000 -7,162,000 -55,000 403,389,000 35,265,000 241,092,000 81,000 98,354,000 20,695,000 28,284,000 56,880,000 56,880,000 4,694,000 4,492,000 52,023,000 52,430,000 14,737,079 28,216,277 3,796,614 86,908,656 1,420,796 44,630 3,536,380 14,163 21,588 15,744,012 17,628,189 35,329,897 26,727,706 24,200,130 272,773 17,442,917 133,476 37,922,042 786,816 936,920 -84,539 -55,487 12,036,893 -100,000 -55,555 -31,594 2,084,746 191,502 770,270 990,143 65,946 894,547 1,958,683 -1,968 13,350 7,848,031 
          net increase in cash, cash equivalents and restricted cash
        363,071,000 5,080,000    -15,925,000       -40,832,000     -27,624,000 -75,193,000   299,287,000 -6,356,000 208,463,000 -60,584,000 67,965,000 -12,551,000 -7,119,000 22,394,000 22,394,000 -28,758,000 -34,952,000 23,425,000 26,179,000                                           
          cash, cash equivalents and restricted cash at beginning of period
        80,490,000 181,192,000 94,218,000 103,577,000 300,151,000 554,698,000  1,000 113,887,000  43,199,000 43,199,000  57,305,000                                           
          cash, cash equivalents and restricted cash at end of period
        443,561,000 5,080,000 -55,032,000 -2,999,000 133,441,000 -15,925,000 112,915,000 7,436,000 76,766,000 -57,966,000 53,896,000 35,543,000 62,745,000 -7,552,000 -37,210,000 -38,602,000 186,941,000 -27,624,000 -75,193,000 -69,806,000 472,774,000  -6,356,000 208,464,000 53,303,000  -12,551,000 -7,119,000 65,593,000 65,593,000  -34,952,000 23,425,000 83,484,000                                           
          reconciliation to amounts on condensed consolidated balance sheets:
                                                                                    
          cash and cash equivalents
        442,209,000 5,067,000 -55,045,000 -3,013,000 132,139,000 -15,928,000 112,912,000 7,433,000 75,477,000 -57,969,000 53,893,000 35,540,000 61,469,000 -7,556,000 -37,213,000 -38,603,000 185,676,000 -27,625,000 -75,195,000 -69,807,000 471,514,000 299,285,000 -6,358,000 208,461,000 52,051,000 67,962,000 -12,553,000 -7,121,000 64,349,000 64,349,000 -28,760,000 -34,954,000 22,776,000 82,896,000                                           
          restricted cash
        1,352,000 13,000 13,000 14,000 1,302,000 3,000 3,000 3,000 1,289,000 3,000 3,000 3,000 1,276,000 4,000 3,000 1,000 1,265,000 1,000 2,000 1,000 1,260,000 2,000 2,000 3,000 1,252,000 3,000 2,000 2,000 1,244,000 1,244,000 2,000 2,000 649,000 588,000                                           
          total cash, cash equivalents and restricted cash
        443,561,000 5,080,000 -55,032,000 -2,999,000 133,441,000 -15,925,000 112,915,000 7,436,000 76,766,000 -57,966,000 53,896,000 35,543,000 62,745,000 -7,552,000 -37,210,000 -38,602,000 186,941,000 -27,624,000 -75,193,000 -69,806,000 472,774,000 299,287,000 -6,356,000 208,464,000 53,303,000 67,965,000 -12,551,000 -7,119,000 65,593,000 65,593,000 -28,758,000 -34,952,000 23,425,000 83,484,000                                           
          cash paid for:
                                                                                    
          interest
        2,385,000 5,910,000 6,099,000 6,097,000 6,143,000 6,422,000 7,112,000 2,488,000 2,448,000 2,433,000 2,409,000 2,180,000 1,749,000 1,537,000 1,286,000 1,038,000 1,584,000 768,000 604,000 1,325,000 769,000 1,054,000 1,892,000 778,000 777,000                                                    
          income taxes
        3,439,000 845,000 1,957,000                                                                          
          noncash transactions
                                                                                    
          reduction of lease liability and right-of-use asset due to lease modification
        1,126,000                                                                            
          adjustments to reconcile net income to net cash from operating activities:
                                                                                    
          noncash stock compensation expense
         15,651,000 17,686,000 16,361,000 14,972,000 11,948,000 11,773,000 9,481,000 9,339,000 9,385,000 9,184,000 12,541,000 6,823,000 11,051,000 6,988,000 -975,000 2,121,000 14,356,000 13,996,000 16,304,000 16,618,000 33,521,000 28,330,000    2,075,000 1,757,000 1,882,000 1,882,000 1,458,000 -173,000 4,264,000 7,337,000 3,569,978 4,890,123 1,489,728 5,995,455 1,328,599 2,834,038 1,648,397 1,698,965 2,857,044 1,240,034 6,242,986 5,357,028 5,038,436 4,096,572                             
          amortization of discount on investment securities
                                                                                    
          change in inventory reserve
                                                                                    
          increase in other current assets
         -1,911,000                   -4,107,000    -1,057,000                -3,449,803 -2,250,490  1,061,924 -957,985 -4,159,055    -988,252                           
          increase in other current liabilities
         266,000 -277,000 -515,000 -1,855,000 1,178,000 -795,000 611,000 3,035,000 651,000 701,000 704,000 619,000 874,000 -337,000 1,201,000 539,000          22,263,000                                                  
          investment in equity investments
                                                                                  
          issuance of common stock
                  1,000                                                                  
          proceeds from debt financings
                25,000,000             312,000 -4,000 -61,000 29,740,000 29,740,000                                               
          reconciliation to amounts on consolidated balance sheets:
                                                                                    
          deferred financing costs
                               -169,000 1,157,000 1,157,000                                               
          warrants issued with debt financing
                               993,000 993,000                                               
          net decrease in cash, cash equivalents and restricted cash
           -2,999,000 -47,751,000   7,436,000 -17,452,000      -37,210,000 -38,602,000 -113,210,000    -81,924,000                                                        
          proceeds from maturity of short-term securities
            80,400,000 73,700,000 92,300,000 71,499,000 73,401,000 23,678,000 26,050,000 30,501,000 16,000,000 20,270,000 28,480,000 25,300,000 13,225,000 15,600,000 11,250,000 11,750,000 17,000,000 8,000,000 15,000,000 11,250,000 9,000,000 6,750,000 9,000,000 6,450,000 7,050,000 7,050,000 6,900,000 11,200,000 8,400,000 6,000,000 8,800,000 5,000,000 6,000,000 11,500,000 3,000,000 6,000,000 9,000,000 10,500,000 6,000,000 4,000,000 3,850,000                               
          investment in long-term securities
            -1,250,000 -250,000 -1,125,000                                                                    
          decrease in accounts receivable
                 -11,773,000 -21,836,000 -8,861,000 -8,623,000 88,000 814,000 487,000                                                            
          purchases of ppe
                     -3,000 -4,000 -7,000 -80,000                                                           
          proceeds from sale of common stock
                             403,377,000 35,226,000   98,357,000 20,699,000 28,287,000 27,678,000 27,678,000 4,694,000 4,492,000 52,023,000 52,430,000 14,737,079 28,216,275 3,796,615 84,765,572 906,972   15,775,638 17,043,830 34,941,049 26,056,167 22,766,685 -427,815 17,219,223                          
          net loss
               6,879,000 -10,707,000   -47,609,000 -39,232,000 -52,994,000 -35,818,000 -40,510,000 -69,013,000 -93,338,000 -85,638,000 -78,497,000 -90,628,000 -88,218,000 -87,163,000      -35,156,000   -33,951,000 -44,142,000 -41,529,000  -31,535,652 -28,353,084 -27,727,509  -24,831,027 -15,899,062 -13,848,662                -17,396,538      -1,633,169 -222,913    127,019  -1,442,087 -1,559,474 -1,904,174   -2,564,257 
          ​
                                                                                    
          decrease in accounts payable and accrued expenses
                                                                  -39,930 24,369 -40,236                
          decrease in deferred revenue
                   -38,000 -38,000 -38,000 -38,000 -38,000 -38,000 -38,000 -38,000 -38,000 -38,000 -38,000 -38,000 -38,000 -38,000 -38,000   -38,000 -38,000 -38,000 -38,000 -38,000 -38,000 -38,095 -38,095 -38,096 -38,095 -38,095 -38,095 -38,095 -38,096 -38,095 -38,095 -38,096 -38,095 -38,095 -38,095                             
          offering costs paid
                          -21,000 -183,000                                  -55,487 -20,416                   
          amortization of premium on investment securities
                       -40,000 23,000 96,000 139,000 155,000 127,000 45,000 -6,000 -25,000 -44,000 -48,000   -75,000 -75,000 -68,000 -42,000 -11,000 2,000 7,460 8,930 14,402 30,528 91,756 113,541 125,803 128,329 158,372 172,361 124,812 80,597 66,321 60,317                             
          shares issued in connection with in-licensing agreement
                                                                                    
          shares issued in connection with in-licensing
                                                                                   
          decrease in other liabilities
                           -146,000 -3,717,000    -18,898,000                                                    
          purchases of equipment
                           -175,000 -67,000 -155,000 -89,000 -45,000 -68,000 -34,000   -14,000 -14,000   -34,000 -24,000     -20,970      -13,397 -6,883 -14,072 -1,333 -3,165                           
          decrease in accrued interest receivable
                             -111,000 64,000 1,000 40,000    14,000 14,000 -14,000 6,000 -8,000 30,000 -108,468 43,290 -20,466 61,028 24,606 25,308 30,340 21,915    -4,194    16,045                           
          increase in lease liabilities
                                                                                    
          increase in interest payable
                             -281,000 348,000 722,000 -832,000 704,000 344,000 -106,000 549,000 549,000                 -94,590 17,266 16,922 16,408 15,910 15,943 15,625 15,151 14,852 277,328 285,724 280,509                
          increase in other liabilities
                             -3,679,000 -4,319,000                                                      
          cash, cash equivalents and restricted cash at beginning of year
                                                                                    
          cash, cash equivalents and restricted cash at end of year
                                                                                    
          noncash licensing expense
                                                                                  
          noncash change in lease liability and right-of-use asset
                              -1,091,000                                                      
          investment in short-term securities
                                                                                    
          decrease in leasehold interest
                                   45,000 46,000 46,000 37,000 45,000 20,000 33,000 36,768 13,147 55,445 19,587                                       
          accrued offering costs
                                   -119,000 179,000 179,000        190,709                                       
          consolidated net loss
                                -51,116,000                  -17,611,812 -13,655,916 -17,103,183 -14,577,735  -17,451,169 -11,986,430 -7,547,249 -5,663,852 -4,556,195 -6,584,552 -3,673,611 -3,502,054 -2,710,201                     
          non-cash stock compensation expense
                                11,068,000                                                    
          non-cash change in lease liability and right-of-use asset
                                2,001,000   529,000 373,000 373,000                                               
          adjustments to reconcile consolidated net loss to net cash from operating activities:
                                                                                    
          change in fair value of notes payable and accrued interest
                                 96,000 -50,000 12,000 66,000 66,000    96,000    105,782 -45,835                                      
          decrease in other assets
                                            242,372    5,341    25,913    8,706         10,859                
          increase in deferred rent
                                      26,000 25,000 23,000 23,000 31,401 28,364 22,289 22,289 22,289 112,248                                     
          proceeds from the exercise of warrants
                                          -1 2,143,084 517,346 50,625 28,108 22,163 57,354 17,341 584,358 408,286 666,319 1,288,245 700,588 901,472  273,762 786,816 936,920                       
          reclassification of deferred financing costs to additional paid-in capital
                                                  -48,022 -15,017                                 
          cash flows from operating activities:
                                                                                    
          depreciation
                                  26,000 23,000 23,000 23,000  23,000 21,000 20,000  20,939 20,654 20,416 20,496 19,145 16,939 6,380 5,126 4,521 3,386 2,419 1,477 896 852 706 493 325 194 115 117    236 411 757 757 1,587 796 1,234 1,234 1,487 1,576 2,848 7,627 7,719 7,912 7,939 10,432 14,096 15,878 
          decrease in prepaid research and development and other current assets
                                  1,563,000 3,117,000 -2,454,000     691,000                                           
          decrease in lease liability
                                    -339,000 -339,000                                               
          cash flows from investing activities:
                                                                                    
          cash flows from financing activities:
                                                                                    
          noncash transactions:
                                                                                    
          shares to be issued in connection with in-licensing
                                                                                    
          increase in prepaid research and development and other current assets
                                     -2,454,000        -3,584,938                                       
          gain on sale of long-term securities
                                                                                   
          proceeds from the sale of long-term securities
                                                                                   
          deferred financing costs paid
                                                    -19,438                               
          reclassification of deferred financing costs to additional paid-in capital
                                          -2,645 31,891                                     
          conversion of convertible notes payable to common stock
                                              2,416                                     
          accrued financing cost
                                                                                    
          increase in restricted cash
                                          -1,032 -1,030 -1,016 -1,005 -1,024 -1,023 -1,010 -1,008 -1,017 -1,016 -1,038 -1,060                               
          net increase in cash and cash equivalents
                                          -35,124,320 14,239,804 -18,035,209 70,606,292 -4,125,241 578,689 -7,900,588 -18,582,909 -10,400,611 5,161,854 -25,704,359 30,290,661 2,487,985   9,110,861 -9,697,931 36,766,445 -1,771,215 -1,267,828 -917,871 -2,993,213 -556,671 11,175,259 -280,228 -98,808 112,648 -597,298 -445,249 1,999,284 -135,645 -140,927 64,072 124,473 70,359 -540,690 -556,770 483,438 -1,382,969 -2,757,934 -3,899,203 5,660,674 
          cash and cash equivalents at beginning of year
                                                                                    
          cash and cash equivalents at end of year
                                                                                    
          financing costs
                                               -5,995 4,011 -8,000                                   
          cash and cash equivalents at beginning of period
                                           25,031,280  55,061,329  55,713,784  40,485,466 16,455,995  9,748,491 478,668 17,996 106,023 649,686 3,029,118 
          cash and cash equivalents at end of period
                                           14,239,804 -18,035,209 95,637,572  578,689 -7,900,588 36,478,420  5,161,854 -25,704,359 86,004,445  16,147,822 -12,518,350 49,596,327 -9,697,931 36,766,445 -1,771,215 15,188,167  -2,993,213 -556,671 20,923,750 -280,228 -98,808 591,316 -597,298 -445,249 2,017,280 -135,645 -140,927 64,072 230,496 70,359 -540,690 -556,770 1,133,124 -1,382,969 -2,757,934 -3,899,203 8,689,792 
          increase in other assets
                                              -1,261 5,995           4,937                         
          accrued financing costs
                                                         427,815        55,487                   
          gain on settlement of notes payable
                                                       -95,427                           
          noncash stock expense associated with in-licensing agreements
                                                                                   
          increase in leasehold interest
                                              475,490 -549,037                                     
          decrease in interest payable
                                                                                    
          proceeds from the exercise of options
                                                      57,200                              
          payment of notes payable
                                                                                  
          deferred rent
                                                 389,554                                   
          increase in prepaid rent
                                                 -1,151,163                                   
          impairment of in-process research and development
                                                                                    
          increase in accrued interest receivable
                                                  -27,494 31,786   -31,695 20,861                             
          adjustments to reconcile consolidated net loss to net cash used in operating activities:
                                                                                    
          noncash stock expense associated with in-licensing agreement
                                                                                    
          investment in held-to-maturity long-term securities
                                                                                    
          investment in held-to-maturity short-term securities
                                                      -9,118,711 -6,127,539                             
          changes in assets and liabilities, net of effects of acquisition:
                                                                                    
          gain on settlement of note payable
                                                                                    
          net decrease in cash and cash equivalents
                                                                                    
          adjustments to reconcile consolidated net loss to cash used in operating activities:
                                                                                    
          stock compensation expense
                                                         4,231,438 947,148 996,755 1,373,768 1,885,477 1,243,592 818,090 1,171,991 188,509                   
          amortization of premiums on investment securities
                                                         15,255                           
          change in fair value and accrued interest of notes payable
                                                         51,025    -54,838 -531,402                      
          cash acquired in connection with acquisition
                                                                                    
          payments of notes payable
                                                         -677,778                           
          proceeds from sale of preferred stock
                                                              12,257,309                   
          conversion of notes payable to preferred stock
                                                                                    
          proceeds from exercise of warrants
                                                                                    
          payments of short-term loans
                                                              -1 -200,000                   
          adjustments to reconcile consolidated net loss to cash from operating activities:
                                                                                    
          stock issued in connection with in-licensing agreement
                                                               16,578,000                   
          increase in prepaid and other current assets
                                                                                    
          increase in accounts payable related party, other accounts payable and accrued expenses
                                                               592,846                     
          non-cash transactions:
                                                                                    
          equity in losses of hedrin jv
                                                                        162,952 105,362 95,900 135,786         
          non cash gain on nordic settlement
                                                                  -4,017,488                
          share-based compensation
                                                                  5,597 5,536 8,077 5,708 15,259 190,882 82,363 78,605 88,373 104,097 84,830 83,396 102,810 192,854 362,771 371,636 371,339 335,210 
          amortization of oid, issue costs and beneficial conversion feature
                                                                  887,198                  
          change in fair value of derivative liability
                                                                  -2,100,898 2,231,746 -170,435                
          loss on early extinguishment of debt
                                                                                   
          shares issued in connection with ariston milestone
                                                                  220,701                
          warrants issued to consultant
                                                                                    
          amortization of intangible assets
                                                                                    
          gain on sale of marketable equity securities
                                                                                    
          noncash portion of in-process research and development charge
                                                                                    
          loss on impairment and disposition of intangible assets
                                                                                    
          other
                                                                                    
          changes in operating assets and liabilities, net of acquisitions:
                                                                                    
          decrease in grant receivable
                                                                                   
          decrease in prepaid expenses and other current assets
                                                                  16,068   5,813 -38,002 88,343 -569    37,704       12,494 
          purchase of property and equipment
                                                                           -1   -2,868 -6,267 
          cash acquired in connection with acquisitions
                                                                                   
          net cash from the purchase and sale of short-term investments
                                                                                    
          proceeds from sale of license
                                                                                    
          proceeds related to sale of common stock
                                                                                -1,968 6,122 7,848,031 
          proceeds from the hedrin jv agreement
                                                                        500,000 -4,054       
          proceeds from sale of notes payable
                                                                                    
          sale of warrant
                                                                                  
          net repayments of notes payable
                                                                  -100,000                
          amortization of oid and issue costs
                                                                    12,062                
          increase in grant receivable
                                                                                    
          increase in prepaid expenses and other current assets
                                                                    75,459                
          interest and amortization of oid and issue costs
                                                                                    
          change in fair value of derivative
                                                                      -2,808,996 942,261 -98,824 -157,778 746,667 70,000         
          non-cash portion of in-process research and development charge
                                                                                    
          decrease in restricted cash
                                                                                    
          proceeds from sale of secured 12% notes
                                                                        340,270         
          proceeds from sale of convertible 12% notes
                                                                                    
          proceeds from 8% note
                                                                                    
          repayment of 8% note
                                                                                    
          proceeds from (repayments of) notes payable
                                                                                    
          repayment of secured 10% notes
                                                                         -70,000         
          amortization of oid and issue costs on secured 12% notes
                                                                         131,405           
          increase in interest payable, current portion
                                                                      61,135 108,246             
          increase in interest payable, noncurrent portion
                                                                                    
          repayments of notes payable
                                                                                    
          proceeds from exercise of warrants and stock options and sale of warrant
                                                                                    
          decrease (increase) in prepaid expenses and other current assets
                                                                                    
          decrease (increase) in other assets
                                                                                    
          net cash provided from the purchase and sale of short-term investments
                                                                                    
          interest and amortization of oid and issue costs on secured 12% notes
                                                                       110,507    119,060         
          non cash portion of in-process research and development charge
                                                                                    
          increase in accounts payable and accrued liabilities
                                                                       -426,062             
          increase in interest payable, non-current portion
                                                                       13,369             
          cash acquired/(paid) in connection with acquisitions
                                                                       519,365             
          repayment of 8% notes
                                                                       -27,000             
          repayments of notes payable to stockholders
                                                                                    
          proceeds (costs) related to sale of common stock
                                                                       2,111,746             
          proceeds from exercise of warrants and stock options
                                                                                  
          supplemental disclosure of cash flow information:
                                                                                    
          interest paid
                                                                       1,506         475 
          supplemental disclosure of noncash investing and financing activities:
                                                                                    
          investment in hedrin jv
                                                                           500,000         
          warrants issued with secured 12% notes
                                                                           53,044         
          common stock issued in satisfaction of accounts payable
                                                                                  
          imputed and accrued preferred stock dividend
                                                                                    
          conversion of preferred stock to common stock
                                                                                    
          preferred stock dividends paid by issuance of shares
                                                                                    
          issuance of common stock for acquisitions
                                                                       1,491,937             
          issuance of common stock in connection with in-licensing agreement
                                                                                    
          marketable equity securities received in connection with sale of license
                                                                                    
          net liabilities assumed over assets acquired in business combination
                                                                                    
          decrease (increase) in restricted cash
                                                                                    
          increase (decrease) in accounts payable
                                                                                    
          increase (decrease) in accrued expenses
                                                                                    
          cash paid in connection with acquisitions
                                                                                    
          proceeds from sale of (repayment of) secured 10% notes
                                                                                    
          proceeds from sale of 8% note
                                                                                    
          warrants issued with 12% notes
                                                                                    
          note issued to settle accrued expenses
                                                                                    
          cashless exercise of warrants
                                                                                  
          increase in accounts payable
                                                                                   150,367 
          increase in accrued expenses
                                                                            -364,231 388,557 49,531 208,038 -346,479 -589,750 859,159 119,218 
          proceeds from sale of secured 10% notes
                                                                                    
          decrease/(increase) in restricted cash
                                                                          339,662 215,870         
          decrease/(increase) in prepaid expenses and other current assets
                                                                          -2,741 -14,850         
          decrease/(increase) in other assets
                                                                                    
          increase/(decrease) in accounts payable
                                                                          28,434 -397,820         
          increase/(decrease) in accrued expenses
                                                                          28,933 -117,672         
          investment in jv
                                                                                    
          decrease in accounts payable
                                                                                    
          equity in loss of hedrin jv
                                                                             140,138       
          loss on sale of fixed assets
                                                                                    
          increase /(decrease) in accounts payable
                                                                             87,977 -368,877 -293,262     
          proceeds from the sale of license
                                                                                    
          proceeds from sale of 10% secured notes
                                                                                    
          (increase)/decrease in prepaid expenses and other current assets
                                                                                    
          investment in hedrin jv’s general partner
                                                                              -13,620     
          imputed preferred stock dividend
                                                                                    
          preferred stock dividends accrued
                                                                                    
          decrease in prepaid expenses
                                                                               -17,693     
          proceeds from the put and warrant issued in the hedrin jv
                                                                               1,958,683     
          loss on sale of marketable equity securities
                                                                                    
          adjustments to reconcile net loss to
                                                                                    
          net cash from operating activities:
                                                                                    
          shares issued in connection with in-licensing agreements
                                                                                    
          proceeds from sale of short-term investments
                                                                                    
          payment for fractional shares for preferred stock dividends
                                                                                    
          issuance of common stock in connection with in-licensing agreements
                                                                                    
          marketable equity securities received in connection with
                                                                                    
          sale of license
                                                                                    
          cash acquired (paid) in connection with acquisitions
                                                                                    
          proceeds from sale (payments for purchase)of short-term investments
                                                                                    
          increase in subscription receivable
                                                                                   -250,000 
          proceeds from sale (payments for purchase) of short-term investments
                                                                                    
          common stock issued in satisfaction of ccounts payable
                                                                                   20,000 
          see accompanying notes to unaudited condensed consolidated financial statements.