7Baggers
Quarterly
Annual
    Unit: USD2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2009-06-12 
      
    		                                                        
      cash flows from operating activities:
    		                                                        
      net income
    		-29,561,000 -30,401,000 -26,639,000 -29,044,000 -24,248,000 -22,243,000 -20,346,000 -16,099,000 -16,599,000 -11,443,000 -10,557,000 -10,300,000 -10,386,000 -9,164,000 -8,300,000 -11,310,000 -10,546,000 -10,941,000 -10,217,000 -13,741,000 -11,063,000 -9,390,000 -15,421,000 -31,719,000 -12,403,000 -21,939,000 -12,112,000 -10,514,000 -12,560,000 -11,593,000 -26,849,000 -6,504,000 -6,816,000 -10,608,000 -5,869,000 -6,035,000 -8,152,000 -10,706,000 -11,207,000 -10,163,000 -9,912,000 -10,151,000 -9,616,000 -7,313,033 -7,866,497 -7,151,889 -6,370,581 -5,704,715 -5,253,531 -4,941,172 -5,580,867 -3,996,756 -3,199,053 -4,211,163 -4,152,517 -3,157,010 
      adjustments to reconcile net income to net cash from operating activities:
    		                                                        
      depreciation and amortization
    		35,000 33,000 30,000 32,000 33,000 33,000 32,000 32,000 29,000 8,000 8,000 7,000 8,000 8,000 8,000 2,000 40,000 47,000 47,000 66,000               11,000 13,000 25,000 29,000 32,000 41,000 38,000 37,000 30,000 25,237 25,775 22,538 11,450 10,779 10,064 8,879 9,795 12,478 10,638 36,739 30,192 32,246 
      reduction in the carrying value of right-of-use assets
    		40,000 40,000 38,000                                                      
      amortization of debt issuance costs
    		128,000 129,000 70,000 68,000 68,000 67,000 68,000 68,000 68,000 67,000 68,000 68,000 68,000 45,000 153,000 139,000 136,000 137,000 140,000 126,000 122,000 125,000 134,000 150,000 140,000 145,000 147,000 136,000 109,000 114,000 109,000 100,000 97,000                        
      loss on extinguishment of debt
    		0 0 546,000                             0 0                        
      accretion on discount to short-term investments
    		-426,000 -801,000 -1,149,000                161,000 145,000 23,000 -44,000 -69,000 -157,000 -316,000 -346,000 -342,000     -102,000                         
      stock-based compensation
    		3,425,000 2,669,000 2,972,000 3,036,000 2,371,000 2,196,000 2,257,000 1,361,000 995,000 958,000 864,000 561,000 450,000 456,000 574,000 853,000 690,000 771,000 946,000 807,000 1,931,000 1,175,000 1,194,000 1,149,000 1,145,000 1,147,000 1,000,000 945,000 1,988,000 392,000 412,000 202,000 114,000                        
      changes in operating assets and liabilities:
    		                                                        
      prepaid expenses and other current assets
    		712,000 880,000 859,000 974,000 -680,000 -2,920,000 243,000 -1,598,000 765,000 116,000 261,000 79,000 -80,000 -301,000 1,638,000 -271,000 -598,000 -1,049,000 879,000 -623,000 1,072,000 -388,000 -195,000 -246,000 279,000 46,000 69,000 -69,000 13,000 29,000 927,000 -838,000 -455,000                        
      non-current assets
    		0 0 -768,000 825,000 0 0 -814,000 780,000 0 -36,000 -756,000 771,000 -25,000 -471,000 -332,000  6,000 -27,000 -863,000  -23,000 9,000 -821,000 803,000 166,000 115,000 -953,000                              
      accounts payable and accrued expenses and other current liabilities
    		3,117,000 1,190,000 -3,148,000 2,260,000 1,375,000 1,336,000 -770,000 1,470,000 3,059,000 988,000 -976,000 445,000 1,699,000 16,000 -2,479,000 -278,000 928,000 -1,632,000 -781,000 70,000 1,166,000 804,000 -3,180,000 139,000 -712,000 188,000 953,000                              
      net cash from operating activities
    		-22,530,000 -26,261,000 -27,189,000 -23,281,000 -22,668,000 -22,495,000 -20,644,000 -15,603,000 -13,160,000 -10,272,000 -12,026,000 -8,651,000 -8,162,000 -9,316,000 -8,425,000 -9,363,000 -8,927,000 -12,194,000 -9,597,000 -12,300,000 -6,705,000 -7,752,000 -13,079,000 -9,946,000 -11,413,000 -12,905,000 -10,859,000 -10,493,000 -8,762,000 -10,349,000 -9,671,000 -9,470,000 -8,249,000 -7,336,000 -3,179,000 -7,329,000 -10,969,000 -7,641,000 -11,328,000 -8,811,000 -8,256,000 -8,533,000 -7,349,000 -6,014,624 -5,368,081 -6,989,992 -6,272,303 -4,860,287 -3,769,045 -4,671,266 -4,488,364 -3,349,540 -3,216,073 -2,941,690 -4,411,565 -4,543,258 
      capex
    		-2,000 -15,000 -3,000 9,000 -3,000 -21,000 -10,000 -24,000 -43,000 -225,000 -4,000 0 -4,000 0 0 -40,000 -11,000 0 0 -5,000 -18,000 -20,000 -4,000 -10,000 -6,000 -36,000 -96,000 -60,000 -16,000 -46,000 -19,000 -434,000 -1,000 0 0 0 -1,000 -2,000 -5,000 -47,000 -27,000 -21,000 -70,000 -10,432 -27,007 -102,941 -6,620 -1,433 -28,172 -12,451 -4,725 -55,266 -4,993 -18,553 -187,363 0 
      free cash flows
    		-22,532,000 -26,276,000 -27,192,000 -23,272,000 -22,671,000 -22,516,000 -20,654,000 -15,627,000 -13,203,000 -10,497,000 -12,030,000 -8,651,000 -8,166,000 -9,316,000 -8,425,000 -9,403,000 -8,938,000 -12,194,000 -9,597,000 -12,305,000 -6,723,000 -7,772,000 -13,083,000 -9,956,000 -11,419,000 -12,941,000 -10,955,000 -10,553,000 -8,778,000 -10,395,000 -9,690,000 -9,904,000 -8,250,000 -7,336,000 -3,179,000 -7,329,000 -10,970,000 -7,643,000 -11,333,000 -8,858,000 -8,283,000 -8,554,000 -7,419,000 -6,025,056 -5,395,088 -7,092,933 -6,278,923 -4,861,720 -3,797,217 -4,683,717 -4,493,089 -3,404,806 -3,221,066 -2,960,243 -4,598,928 -4,543,258 
      cash flows from investing activities:
    		                                                        
      purchase of property and equipment
    		-2,000 -15,000 -3,000 9,000 -3,000 -21,000 -10,000 -24,000 -43,000 -225,000 -4,000 0 -4,000   -40,000 -11,000   -5,000 -18,000 -20,000 -4,000 -10,000 -6,000 -36,000 -96,000 -60,000 -16,000 -46,000 -19,000 -434,000 -1,000                        
      purchase of available-for-sale securities
    		-22,930,000 -39,658,000 -15,068,000 -32,064,000 -138,714,000 -3,441,000 -30,697,000 -38,805,000 -94,543,000 -30,781,000 -30,091,000 -73,411,000 0 0 -16,004,000 -22,528,000 -24,096,000 -20,126,000 -94,319,000 -15,926,000 -34,543,000 0 -35,614,000 -18,741,000 -12,006,000 -46,163,000 -46,035,000 -34,390,000 -63,380,000 -8,833,000 -15,891,000 -43,419,000                         
      maturity of available-for-sale securities
    		44,400,000 64,000,000 44,400,000 49,950,000 40,550,000 33,000,000 41,500,000 45,400,000 38,000,000 30,000,000 24,000,000 14,200,000 33,000,000 25,200,000 58,393,000                                          
      net cash from investing activities
    		21,468,000 24,327,000 29,329,000 17,895,000 -98,167,000 29,538,000 10,793,000 6,571,000 -56,586,000 -1,006,000 -6,095,000 -59,211,000 32,996,000 25,195,000 53,665,000 -1,268,000 12,983,000 -3,432,000 -77,739,000 -381,000 -6,861,000 18,080,000 -1,785,000    7,320,000 869,000    -39,053,000 -33,444,000 553,000 2,829,000 3,686,000         2,812,393   426,562    -253,266 -702,993 -2,149,553 -4,059,363  
      cash flows from financing activities:
    		                                                        
      repayment of long-term debt
    		1,000 0 -27,230,000         0 0                   0 0                        
      proceeds from long-term debt
    		0 0 29,598,000         0 0                                            
      issuance of common stock in underwritten public offering, net of offering costs
    		                                                        
      issuance of common stock upon at the market offerings
    		   0                0 0   1,000 5,664,000 19,037,000 4,890,000 12,000 0 0 493,000 675,000 891,000                        
      proceeds from exercise of stock options
    		0 65,000 165,000 48,000 237,000 11,000 51,000 89,000 63,000 104,000 27,000     1,000 10,000 3,000 2,000 0 0 38,000 48,000 -1,000 44,000 61,000 6,000 8,000 17,000 30,000 3,000                          
      reimbursement of commissions from the prior issuance of common stock upon at the market sales
    		   0 0                                                    
      repurchase of shares for minimum tax withholdings
    		-24,000 -114,000 -215,000 -897,000 -94,000 -2,000 -2,000 -1,025,000 -182,000 0 -1,000 -1,000 -1,000 0 -1,000                                          
      net cash from financing activities
    		-23,000 -49,000 2,318,000 -843,000 118,316,000 55,000 49,000 7,895,000 74,755,000 104,000 26,000 1,000 -1,000 88,000 -1,000 6,000 10,000 324,000 120,466,000 0 1,827,000 2,328,000 -466,000 25,248,000 5,708,000 19,056,000 4,896,000 9,096,000 45,810,000 16,000 271,000 50,756,000 435,000   -8,336,000 2,851,000   -48,000 14,818,000   20,242,403 2,168,841 3,902,233 7,977,523 -116,337 -242,612     -3,170 -47,742  
      effect of exchange rate changes on cash and cash equivalents
    		-74,000 -137,000 -30,000 -70,000 82,000 -19,000 2,000 32,000 -64,000 -65,000 -21,000 120,000 -145,000 -41,000 -24,000 -62,000 -20,000 -27,000 -28,000 342,000 -159,000 -54,000 41,000 -34,000 70,000 -71,000 13,000 -117,000 6,000 -19,000 11,000 75,000 -62,000                        
      increase in cash and cash equivalents
    		-1,159,000 -2,120,000 4,428,000     -1,105,000 4,945,000 -11,239,000 -18,116,000 -67,741,000 24,688,000 15,926,000 45,215,000 -10,687,000 4,046,000 -15,329,000 33,102,000    -15,289,000 32,019,000 955,000 -8,841,000 1,370,000 -645,000                             
      cash and cash equivalents beginning of period
    		0 0 15,128,000 0 0 0 26,585,000 0 0 0 52,100,000 0 0 0 34,012,000 0 0 0 22,880,000 0 0 0 49,804,000 0 0 0 24,301,000 0 0 0 22,121,000 0 0                        
      cash and cash equivalents end of period
    		-1,159,000 -2,120,000 19,556,000 -6,299,000 -2,437,000 7,079,000 16,785,000 -1,105,000 4,945,000 -11,239,000 33,984,000 -67,741,000 24,688,000 15,926,000 79,227,000 -10,687,000 4,046,000 -15,329,000 55,982,000 -12,339,000 -11,898,000 12,602,000 34,515,000 32,019,000 955,000 -8,841,000 25,671,000 -645,000 1,342,000 1,482,000 22,122,000 2,308,000 -41,320,000                        
      supplemental disclosure of cash flow information:
    		                                                        
      cash paid for interest
    		720,000 499,000 1,325,000 505,000 541,000 542,000 536,000 536,000 531,000 509,000 464,000 428,000 329,000 373,000 484,000         503,000 538,000 530,000 528,000 368,000 353,000 351,000 334,000                          
      foreign currency loss
    		              13,000          -116,000 -110,000 59,000                              
      issuance of common stock and pre-funded warrants in underwritten offering, net of offering costs
    		                                                        
      issuance of common stock issued in underwritten offering, net of offering costs
    		                                                        
      issuance of common stock upon exercise of prefunded warrants
    		                                                        
      decrease in cash and cash equivalents
    		   -6,299,000 -2,437,000 7,079,000 -9,800,000              -11,898,000                                    
      amortization of right-of-use assets
    		    36,000 36,000 35,000 34,000 33,000 16,000 15,000 35,000 35,000 33,000 33,000 135,000 -20,000 59,000 57,000 53,000                                     
      accretion on premium to short-term investments
    		    -1,477,000 -1,125,000 -1,370,000                                                  
      issuance of common stock and pre-funded warrants in underwritten public offering, net of offering costs
    		                                                        
      foreign currency gain
    		     125,000 21,000 -12,000 -2,000       77,000 7,000 -42,000 57,000                                      
      (accretion on discount)/amortization on premium to short-term investments
    		                                                        
      sale of available-for-sale securities
    		           0 0 0 11,276,000 5,700,000     0 3,000,000 5,780,000  2,000 3,478,000 10,651,000                              
      issuance of common stock and pre-funded warrants in registered direct offering, net of offering costs
    		       0                                                 
      amortization on premium to short-term investments
    		        -1,508,000 -913,000 -924,000 -357,000 61,000 104,000 267,000                                          
      foreign currency (gain) loss
    		          -29,000  8,000          -156,000                                  
      non-cash interest income
    		                                                        
      long-term liabilities
    		               74,000 -71,000 -24,000 -23,000 -20,000 56,000 -162,000 -305,000  -76,000 90,000 -193,000                              
      repurchase of outstanding pre-funded warrants
    		               0 0 0 -3,909,000                                      
      issuance of common stock and pre-funded warrants in public offering, net of offering costs
    		               83,000 0 321,000 121,827,000                                      
      issuance of common stock upon exercise of warrants
    		               0 0 0 2,546,000 0        0 0 1,000 18,000 0 -1,000                        
      acquired in-process research and development
    		                   0 0 0 5,367,000                                  
      change in fair value of financial instruments
    		                                                        
      purchase of in-process research and development
    		                                                        
      non-cash transactions:
    		                                                        
      common stock issued for acquired in-process research and development
    		                                                        
      changes in fair value of financial instruments
    		                    -60,000 -54,000 -2,000  136,000 41,000 77,000  -10,000 -34,000 96,000 0 43,000                        
      noncash interest expense
    		                                                        
      amortization (accretion) on premium or discount to short-term investments
    		                501,000                                        
      maturities of available-for-sale securities
    		                34,590,000 16,700,000 16,580,000 15,550,000 27,700,000 15,100,000 31,300,000 35,500,000 18,600,000 27,800,000 42,800,000 34,400,000 24,846,000 14,200,000 25,300,000                          
      non-cash transactions
    		                                                        
      cash paid for interest, including end of period charge due upon long-term debt amendment
    		                                                        
      repayment of debt facility
    		                   0 0 0 -514,000                                  
      cash paid for interest, including end of period charge due upon debt facility amendment
    		                 490,000 484,000                                      
      impairment of goodwill
    		                       19,432,000 0                                
      change in fair value of contingent consideration
    		                       0 0 131,000 133,000 135,000 134,000 131,000 -134,000 132,000 131,000                        
      noncash interest income
    		                     10,000 133,000                                  
      gain on short-term investments
    		                                                        
      sales of available-for-sale securities
    		                                                        
      issuance of securities in private financing
    		                                                        
      capital lease obligation principal payments
    		                       1,000 0   -289,000 1,000 -15,000 -243,000 0 -455,000                        
      settlement of contingent consideration
    		                       0 0                                
      purchase in-process research and development
    		                    0 0 -3,247,000                                  
      acquisition of in-process research and development
    		                    0 0 -2,120,000                                  
      cash paid for interest including end of period charge due upon debt facility amendment
    		                    495,000                                    
      depreciation and amortization including right-of-use assets
    		                     213,000 242,000 238,000 233,000 232,000 307,000                              
      cash paid for interest and end of period charge due upon debt facility amendment
    		                      990,000                                  
      impairment of acquired ipr&d
    		                           0 0 0 21,692,000                          
      non-cash interest (income) / expense
    		                                                        
      write-off of ipr&d upon acquisition
    		                                                        
      benefit for deferred taxes
    		                           -2,502,000 0 0 -4,555,000                          
      proceeds from debt facility
    		                               0 0                        
      issuance of common stock upon public offering
    		                           0    50,076,000 0                        
      common stock issued for ipr&d
    		                           0 0                            
      noncash interest (income) / expense
    		                        111,000 -65,000 -4,000                              
      acquired ipr&d
    		                            0                            
      net cash used by investing activities
    		                                                        
      issuance of common stock upon public offerings
    		                                                        
      noncash transaction:
    		                                                        
      net cash provided (used) by investing activities
    		                                                        
      depreciation
    		                           139,000 127,000 153,000 107,000 91,000 91,000                        
      non-cash interest
    		                                                        
      write-off of acquired ipr&d
    		                                                        
      accretion on discount to short-term investments and convertible promissory notes
    		                           -354,000 -268,000 -140,000 -138,000                          
      issuance of call option derivative
    		                               0                         
      grant and award receivable
    		                               0 0                        
      cash acquired through merger
    		                               0 0                        
      proceeds from convertible promissory notes
    		                                                        
      extinguishment and derecognition of put options
    		                               0 0                        
      conversion of convertible notes into common stock
    		                               0 0                        
      shares issued in connection of business combination and assumed equity awards
    		                               0 0                        
      accretion of redeemable convertible preferred stock
    		                                                        
      beneficial conversion feature
    		                               0 0                        
      noncash interest
    		                            29,000 19,000 35,000 -59,000 -5,000                        
      foreign currency gain/
    		                            7,000 -155,000 61,000  71,000                        
      tax refund receivable
    		                            -156,000 -364,000 -873,000 331,000 -119,000                        
      deferred rent
    		                            -10,000 -6,000 -7,000 -12,000 -7,000                        
      accounts payable and accrued expenses
    		                            1,835,000 110,000 -554,000 16,000 -1,704,000                        
      net cash from / (used in) investing activities
    		                             11,834,000 9,390,000                          
      cash flows from financing activity:
    		                                                        
      increase / (decrease) in cash and cash equivalents
    		                             1,482,000 1,000 2,308,000 -41,320,000                        
      accretion on discount to convertible promissory notes
    		                                                        
      proceeds from convertible promissory note
    		                               0 0                        
      proceeds from issuance of series c preferred stock
    		                                                        
      net assets acquired in business combination of serendex
    		                                                        
      equipment under capital lease
    		                                                        
      contingent liability related to purchase of serendex
    		                                                        
      conversion of convertible notes into preferred stock
    		                                                        
      accretion of series a redeemable convertible preferred stock
    		                               0 0                        
      accretion of series b redeemable convertible preferred stock
    		                               0 0                        
      accretion of series c redeemable convertible preferred stock
    		                               0 0                        
      cash paid for income taxes
    		                                                        
      proceeds from exercise of stock option
    		                                                        
      issuance of common stock for serendex
    		                                                        
      share-based compensation expense related to employee stock options
    		                                  461,000 692,000 645,000 647,000 659,000                  
      amortization of debt issuance costs and debt discount
    		                                  104,000 62,000 615,000 163,000 169,000 156,000                 
      changes in assets and liabilities:
    		                                                        
      decrease in prepaid expenses and other assets
    		                                  515,000    153,000    438,000          -204,810    
      decrease in accounts payable
    		                                  -127,000                      
      increase/(decrease) in accrued liabilities
    		                                  1,726,000                      
      proceeds from maturities of certificates of deposit
    		                                  498,000 3,686,000 4,150,000 2,988,000 4,383,000 4,980,000 4,707,000 2,490,000 4,847,000 2,581,000 7,452,000 947,000 5,679,000 2,988,000 4,722,000 3,145,000 6,393,000      
      proceeds from sales of certificates of deposit
    		                                  2,241,000                      
      security deposit for sublease
    		                                  90,000                      
      purchases of property and equipment
    		                                   0 -1,000 -2,000 -5,000 -47,000 -27,000 -21,000 -70,000 -10,432 -27,007 -102,941 -6,620 -1,433 -28,172 -12,451 -4,725 -55,266 -4,993 -18,553 -187,363  
      payments made on debt facility
    		                                  -368,000 -10,359,000                     
      costs paid in connection with debt facility
    		                                  -50,000 0 -76,000 -9,000 -38,000                  
      proceeds from sale of common stock
    		                                   2,016,000 3,909,000 5,973,000 8,060,000 0 0 2,131,000 9,000 15,435,454 2,291,068 4,181,080 8,293,398 0 0        
      payments for offering costs
    		                                   -56,000 -94,000 -338,000 -601,000 -13,000 -20,000 -96,000 -13,000              
      payments for capital lease
    		                                  -3,000 -2,000 -2,000 -2,000 -2,000 -2,000 -2,000 -1,000 -2,000              
      net cash (used in)/provided by financing activities
    		                                  -421,000        -6,000              
      net (decrease)/increase in cash and cash equivalents
    		                                  -771,000     -9,155,000 10,993,000 -6,720,000 -7,874,000        -1,090,517  -3,868,154 -5,094,413 -8,518,670  
      cash and cash equivalents at beginning of period
    		                                  8,542,000 0 0 0 23,052,000 0 0 0 35,808,000 -92 0 0 25,681,092 0 0 0 22,500,440 0 0 0 43,569,947 9,849,904 
      cash and cash equivalents at end of period
    		                                  7,771,000 -11,979,000 -3,969,000 969,000 23,521,000 -9,155,000 10,993,000 -6,720,000 27,934,000 9,826,395 -386,847 -3,479,700 29,848,152 -4,550,062 -14,741,082 23,562,313 21,409,923 -3,588,270 -3,868,154 -5,094,413 35,051,277 5,306,646 
      gain on bargain purchase
    		                                           -56 0 -33,000 -452,944          
      impairment of ipr&d
    		                                                        
      benefit for deferred tax liability
    		                                                        
      write-off of property and equipment
    		                                                        
      changes in assets and liabilities, net of effect of acquisitions:
    		                                                        
      increase/(decrease) in prepaid expenses and other assets
    		                                                        
      (decrease)/increase in accounts payable
    		                                                        
      (decrease)/increase in accrued liabilities
    		                                                        
      purchases of certificates of deposit
    		                                       -5,478,000 -249,000 -2,690,000 -5,296,000 -6,971,980 -4,482,000 -1,236,000 -6,745,020 -2,560,005 -15,423,030 -996,000 -2,988,000 -2,241,000 -4,722,000 -3,547,000 -5,312,000  
      security deposit for new lease
    		                                                        
      cash obtained through acquisition
    		                                           -480 0            
      proceeds from borrowings under debt facility
    		                                                        
      proceeds from sale and exercise of warrants
    		                                                        
      decrease/(increase) in prepaid expenses and other assets
    		                                    -539,000        -28,081 -113,627 202,314    140,213      
      (decrease)/increase in accounts payable and accrued liabilities
    		                                      -1,134,000       -138,396 -61,996          
      proceeds from exercise of warrants
    		                                            0            
      net decrease in cash and cash equivalents
    		                                                        
      increase in accounts payable and accrued liabilities
    		                                           872,902    972,973 1,009,943   -7,016 80,874 580,102 -533,492 -1,534,852 
      net cash provided by/(used in) investing activities
    		                                     2,986,000 4,378,000        2,461,840   2,136,549 3,400,275      
      net increase/(decrease) in cash and cash equivalents
    		                                     969,000 469,000        4,167,060  -14,741,082        
      net cash provided by/(used in) financing activities
    		                                      7,419,000                  
      write-off of fixed assets
    		                                                    0    
      increase in accounts payable
    		                                                        
      increase in accrued liabilities
    		                                                        
      share-based compensation expense
    		                                        544,000 512,000 1,066,000              
      (increase)/decrease in prepaid expenses and other assets
    		                                        -127,000                
      security deposit for new sublease
    		                                                        
      net cash (used in)/provided by investing activities
    		                                        4,431,000 -221,000 -519,000              
      proceeds from borrowings under term loan
    		                                                        
      costs paid in connection with term loan
    		                                                        
      increase/(decrease) in accounts payable and accrued liabilities
    		                                         1,631,000 733,000        563,439      
      loss on change in fair value of contingent consideration
    		                                                        
      increase in prepaid expenses and other assets
    		                                                      -34,078 -57,879 
      effect of exchange rate changes on cash
    		                                               0 -223 1,129 -2,428      
      net increase in cash and cash equivalents
    		                                           9,826,487 -386,847           -4,543,258 
      share-based compensation expense related to employee stock options and restricted stock issued
    		                                            689,232 424,382 399,454 440,801 442,328 365,137 351,556 385,458 359,543 336,824 377,505  
      payments for financing and offering costs
    		                                            -122,227 -278,912 -315,875 -116,337 -242,612     -3,170 -47,742  
      loss on disposals of equipment
    		                                                        
      loss on fair value of warrants
    		                                                        
      loss/(gain) on change in fair value of contingent consideration
    		                                               0 0 7,500 27,500      
      amortization of debt discount
    		                                                        
      forgiveness of employee receivable
    		                                                        
      impairment loss – write-off of goodwill
    		                                                        
      expenses related to options issued to non-employees
    		                                                        
      expenses paid by issuance of common stock
    		                                                        
      expenses paid by issuance of warrants
    		                                                        
      expenses paid by issuance of preferred stock
    		                                                        
      expenses related to stock warrants issued
    		                                                        
      equity in loss of investee
    		                                                        
      in-process research and development
    		                                                        
      write-off of license agreement
    		                                                        
      impairment of equipment
    		                                                        
      cumulative effect of change in accounting principle
    		                                                        
      amortization of premium / (accretion of discount) on investments in securities
    		                                                   0 2,957 8,173 10,710  
      proceeds from sale of certificate of deposit
    		                                                        
      purchases of other investment securities
    		                                                        
      proceeds from maturities and sales of other investment securities
    		                                                        
      proceeds from sale of property and equipment
    		                                                        
      cash obtained through acquisitions, net of cash paid
    		                                              3,534,480          
      payment on obligation under license agreement
    		                                                        
      issuance of note receivable – related party
    		                                                        
      payments on note receivable
    		                                                        
      advance to investee
    		                                                        
      cash transferred in rescission of acquisition
    		                                                        
      cash received in rescission of acquisition
    		                                                        
      proceeds from sale or exercise of warrants
    		                                                        
      proceeds from sale of preferred stock
    		                                                        
      repurchase of subject to vesting shares
    		                                                        
      repurchase of warrants
    		                                                        
      payments on notes payable and long-term debt
    		                                                        
      proceeds from issuance of notes payable and detachable warrants
    		                                                        
      cash paid in lieu of fractional shares for reverse stock split
    		                                                        
      impairment loss — write-off of goodwill
    		                                                        
      amortization of premium/(accretion of discount) on investments in securities
    		                                                        
      increase in prepaid and other current assets
    		                                                        
      cash paid for acquisitions, net of cash acquired
    		                                                        
      issuance of note receivable — related party
    		                                                        
      issuance of note receivable - related party
    		                                                        
      purchases of other short-term investments
    		                                                        
      proceeds from maturities and sales of other short-term investments
    		                                                        
      gain on disposals of equipment
    		                                                        
      gain on change in fair value of contingent consideration
    		                                                   105,109   -114,388  
      increase in prepaid and other assets
    		                                                        
      (gain) loss on disposals of fixed assets
    		                                                    0 0 4,503  
      expense related to options issued to non-employees
    		                                                        
      proceeds from maturities and sales of certificates of deposit
    		                                                        
      (gain) loss on change in fair value of contingent consideration
    		                                                        
      maturity of certificates of deposit
    		                                                     1,416,000 1,440,000  
      proceeds from sales and maturities of other short-term investments
    		                                                        
      write-off of assets available-for-sale
    		                                                        
      (gain) loss on disposal of fixed assets
    		                                                        
      write-off assets available-for-sale
    		                                                        
      proceeds from sales and maturities of short-term investments
    		                                                        
      purchases of short-term investments
    		                                                        
      expenses related to share-based compensation
    		                                                        
      expense related to stock options issued to non-employees
    		                                                        
      accretion of discount on investments in securities
    		                                                        
      purchase of certificate of deposit
    		                                                        
      maturity of certificate of deposit
    		                                                        
      cash acquired from acquisitions, net of cash paid
    		                                                        
      proceeds of restricted cash for preferred stock dividends
    		                                                        
      payment to escrow for preferred stock dividends obligation
    		                                                        
      loss on disposals of fixed assets
    		                                                        
      expenses related to employee stock options and restricted stock issued
    		                                                        
      net increase in cash
    		                                                        
      cash at beginning of period
    		                                                        
      cash at end of period
    		                                                        
      1.
    		                                                        
      gain on disposal of fixed assets
    		                                                       279 
      fair value of warrant liability
    		                                                        
      expenses related to employee stock options
    		                                                       173,958 
      expenses paid by warrants
    		                                                        
      expenses paid by preferred stock
    		                                                        
      accretion of discount
    		                                                        
      gain /loss on disposals of property and equipment
    		                                                        
      decrease in other long-term liabilities
    		                                                        
      payment of financing and offering costs
    		                                                        
      payments of notes payable and long-term debt
    		                                                        
      share-based compensation for employee awards
    		                                                        
      increase in other long-term liabilities
    		                                                        
      share-based compensation for employee equity awards
    		                                                        
      share-based compensation for non-employee options
    		                                                        
      expenses paid by issuance of common stock to non-employees
    		                                                        
      write-off of assets available for sale
    		                                                        
      payments of financing and offering costs
    		                                                        
      loss on fair value of warrant liability
    		                                                        
      expenses related to employee stock options issued
    		                                                        
      write-off assets available for sale
    		                                                        
      increase in long-term liabilities
    		                                                        
      impairment loss — write off of goodwill
    		                                                        
      increase in sponsored research payable and license obligation
    		                                                        
      cash acquired in acquisition of subsidiary
    		                                                        
    The information provided in this report is taken from www.sec.gov and many other data providers. While we have conducted our best efforts to ensure that the parsed data is accurate, we cannot guarantee its accuracy. Please use caution and understand that any consequences of its use are your own responsibility.