7Baggers

Stoke Therapeutics, Inc
(NASDAQ:STOK) 

STOK stock logo

Stoke Therapeutics, Inc., an early-stage biopharmaceutical company, develops novel antisense oligonucleotide (ASO) medicines to treat the underlying causes of severe genetic diseases in the United States. The company utilizes its proprietary ribonucleic acid therapeutics platform, Targeted Augmentat...

Founded: 2015
IPO Price: $18 (Jun 19, 2019)
Full Time Employees: 56
CEO: Edward M. Kaye  
Sector: Healthcare
Industry: Biotechnology

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At a glance:
Bull Thesis:
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Moat:
Income Statements:
Quarterly
Annual
    Unit: USD2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 
                               
      revenue
    1,402,000 10,632,000 13,817,000 158,569,000 22,614,000 4,894,000 4,831,000 4,216,000 2,802,000 3,308,000 -2,481,000 5,152,000 3,268,000 2,905,000 3,231,000 3,000,000            
      yoy
    -93.80% 117.25% 186.01% 3661.12% 707.07% 47.94% -294.72% -18.17% -14.26% 13.87% -176.79% 71.73%  NaN% NaN% NaN%  NaN% NaN% NaN%  NaN% NaN%     
      qoq
    -86.81% -23.05% -91.29% 601.20% 362.08% 1.30% 14.59% 50.46% -15.30% -233.33% -148.16% 57.65% 12.50% -10.09% 7.70%   NaN% NaN%   NaN% NaN%   NaN%  
      operating expenses:
                               
      research and development
    41,695,000 37,696,000 25,855,000 32,676,000 23,423,000 22,205,000 21,136,000 22,368,000 21,778,000 20,271,000 20,551,000 19,631,000 21,060,000 20,109,000 18,358,000 18,309,000 15,802,000 14,358,000 14,095,000 9,913,000 8,904,000 8,109,000 7,968,000 7,215,000 7,089,000 6,518,000 6,023,000 
      sales, general and administrative
    21,146,000 16,027,000                          
      total operating expenses
    62,841,000 53,723,000 41,117,000 47,329,000 36,267,000 34,897,000 34,173,000 32,588,000 32,388,000 30,542,000 30,781,000 29,842,000 30,444,000 30,053,000 28,469,000 27,795,000 24,526,000 22,683,000 22,029,000 16,827,000 14,586,000 13,711,000 13,012,000 11,735,000 11,068,000 9,842,000 8,445,000 
      income from operations
    -61,439,000 -43,091,000 -27,300,000 111,240,000 -13,653,000 -30,003,000 -29,342,000 -28,372,000 -29,586,000 -27,234,000 -33,262,000 -24,690,000 -27,176,000 -27,148,000 -25,238,000 -24,795,000 -24,526,000 -22,683,000 -22,029,000 -16,827,000 -14,586,000 -13,711,000 -13,012,000 -11,735,000 -11,068,000 -9,842,000 -8,445,000 
      yoy
    350.00% 43.62% -6.96% -492.08% -53.85% 10.17% -11.79% 14.91% 8.87% 0.32% 31.79% -0.42% 10.80% 19.68% 14.57% 47.35% 68.15% 65.44% 69.30% 43.39% 31.79% 39.31% 54.08%     
      qoq
    42.58% 57.84% -124.54% -914.77% -54.49% 2.25% 3.42% -4.10% 8.64% -18.12% 34.72% -9.15% 0.10% 7.57% 1.79% 1.10% 8.13% 2.97% 30.91% 15.36% 6.38% 5.37% 10.88% 6.03% 12.46% 16.54%  
      operating margin %
    -4382.24% -405.30% -197.58% 70.15% -60.37% -613.06% -607.37% -672.96% -1055.89% -823.28% 1340.67% -479.23% -831.58% -934.53% -781.12% -826.50% -Infinity% NaN% NaN% NaN% -Infinity% NaN% NaN% NaN% -Infinity% NaN% NaN% 
      other income:
                               
      interest income
    3,615,000 3,463,000 3,789,000 2,889,000 2,970,000 3,545,000 3,695,000 2,426,000 2,587,000 2,651,000 2,567,000 2,103,000 1,479,000 995,000 544,000 104,000 36,000 44,000 34,000 18,000 10,000 11,000 50,000 674,000 904,000 1,236,000 629,000 
      other income
    -110,000 3,000 28,000 28,000 201,000 28,000 -48,000 -428,000 41,000 41,000 41,000 42,000 42,000 42,000 42,000 42,000 42,000 42,000 28,000 16,000 15,000 16,000 3,000 22,000 4,000 2,000  
      total other income
    3,505,000 3,466,000 3,817,000 2,917,000 3,171,000 3,573,000 3,647,000 1,998,000 2,628,000 2,692,000 2,608,000 2,145,000 1,521,000 1,037,000 586,000 146,000 78,000 86,000 62,000 34,000 25,000 27,000 53,000 696,000 908,000 1,238,000 626,000 
      income before income taxes
    12,762,250 -39,625,000 -23,483,000 114,157,000                        
      provision for income taxes
     -1,278,000  1,278,000                        
      net income
    -57,934,000 -38,347,000 -23,483,000 112,879,000 -10,482,000 -26,430,000 -25,695,000 -26,374,000 -26,958,000 -24,542,000 -30,654,000 -22,545,000 -25,655,000 -26,111,000 -24,652,000 -24,649,000 -24,448,000 -22,597,000 -21,967,000        -7,819,000 
      yoy
    452.70% 45.09% -8.61% -527.99% -61.12% 7.69% -16.18% 16.98% 5.08% -6.01% 24.35% -8.54% 4.94% 15.55% 12.22%             
      qoq
    51.08% 63.30% -120.80% -1176.88% -60.34% 2.86% -2.57% -2.17% 9.84% -19.94% 35.97% -12.12% -1.75% 5.92% 0.01% 0.82% 8.19% 2.87%          
      net income margin %
    -4132.24% -360.68% -169.96% 71.19% -46.35% -540.05% -531.88% -625.57% -962.10% -741.90% 1235.55% -437.60% -785.04% -898.83% -762.98% -821.63% -Infinity% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% 
      net income per share
        -0.17 -0.47 -0.46 -0.57 -0.6 -0.55 -0.69 -0.53 -0.65 -0.66 -0.63 -0.66 -0.67 -0.61 -0.6 -0.46 -0.42 -0.41 -0.39 -0.34 -0.09 -0.26 -1.54 
      basic
    0.22 -0.65 -0.4 1.95                        
      diluted
    0.213 -0.65 -0.4 1.9                        
      weighted-average common shares outstanding:
                               
      basic
     58,611,677 58,353,855 57,862,674                        
      diluted
     58,611,677 58,353,855 59,398,600                        
      comprehensive income:
                               
      other comprehensive gain:
                               
      unrealized gain on marketable securities
    97 350 200 47 -317 181 -15 24 123 232 219 577 -383.75 -427  -516 -5.5 20          
      total other comprehensive gain
    97 350 200 47 -317 181 -15 24                    
      comprehensive income
    12,911.5 -37,997 -23,283 112,926                        
      general and administrative
      15,262,000 14,653,000 12,844,000 12,692,000 13,037,000 10,220,000 10,610,000 10,271,000 10,230,000 10,211,000 9,384,000 9,944,000 10,111,000 9,486,000 8,724,000 8,325,000 7,934,000 6,914,000 5,682,000 5,602,000 5,044,000 4,520,000 3,979,000 3,324,000 2,422,000 
      net income per share
        -0.17 -0.47 -0.46 -0.57 -0.6 -0.55 -0.69 -0.53 -0.65 -0.66 -0.63 -0.66 -0.67 -0.61 -0.6 -0.46 -0.42 -0.41 -0.39 -0.34 -0.09 -0.26 -1.54 
      weighted-average common shares outstanding, basic and diluted
         56,341,074 55,765,948 46,246,889  44,266,017 44,188,464 42,536,474  39,420,310 39,258,358 37,448,301  36,759,319 36,708,188 36,643,205  33,273,597 33,054,656 32,897,395  32,707,647 5,083,620 
      comprehensive loss:
                               
      comprehensive loss
        -10,799 -26,249 -25,710 -26,350 -26,835 -24,310 -30,435 -21,968 -25,127 -26,538 -25,244 -25,165 -24,594 -22,577 -21,925         
      total other comprehensive loss
            257 232 219 577 528 -427 -592 -516 -146 20 -42         
      other comprehensive loss:
                               
      unrealized loss on marketable securities
                  -592    -42         
      net loss and comprehensive loss
                       -16,793,000 -14,561,000 -13,684,000 -12,959,000 -11,039,000 -10,160,000 -8,604,000  
      other expense
                              -3,000 
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 
                                 
        assets
                                 
        current assets:
                                 
        cash and cash equivalents
      84,220,000 83,394,000 101,472,000 274,817,000 127,983,000 150,016,000 193,476,000 178,581,000 191,442,000 189,977,000 192,060,000 190,339,000 113,556,000 113,396,000 67,754,000 84,111,000 144,895,000 149,038,000 169,070,000 267,514,000 287,308,000 191,461,000 201,930,000 211,288,000 222,471,000 233,049,000 242,680,000 
        marketable securities - short term
      200,450,000    88,916,000                       
        accounts receivable
      5,936,000 9,248,000                          
        prepaid expenses
      8,736,000 7,747,000 13,694,000 12,694,000 11,117,000 9,837,000 10,345,000 10,722,000 11,320,000 10,936,000 10,950,000 10,191,000 10,932,000               
        other current assets
      3,895,000 5,543,000 6,871,000 5,037,000 3,965,000 3,809,000 4,287,000 3,559,000 2,561,000 4,269,000 3,699,000 5,880,000 2,955,000               
        restricted cash - short term
      494,000    75,000                       
        interest receivable
      1,969,000 1,589,000 1,622,000 606,000 700,000 691,000 305,000 11,000 64,000 96,000 136,000 492,000 588,000 395,000 350,000 265,000 132,000 45,000 131,000 6,000 6,000 2,000 9,000 144,000 281,000 376,000 260,000 
        total current assets
      305,700,000 272,437,000 269,970,000 375,736,000 232,756,000 253,612,000 296,994,000 193,275,000 215,339,000 230,019,000 246,232,000 270,236,000 244,070,000 264,601,000 289,159,000 305,771,000 229,218,000 244,933,000 260,233,000 275,295,000 293,930,000 195,456,000 205,544,000 215,774,000 226,033,000 236,680,000 244,445,000 
        restricted cash - long term
      227,000    721,000                       
        operating lease right-of-use assets
      3,101,000 3,708,000 3,218,000 3,831,000 4,345,000 4,928,000 5,499,000 6,060,000 6,611,000 3,084,000 3,646,000 4,202,000 4,753,000 5,295,000 5,831,000 4,563,000 4,939,000 5,326,000 1,258,000 844,000 1,115,000 1,381,000 1,642,000 1,900,000    
        marketable securities - long term
      106,260,000    29,824,000                       
        property and equipment
      3,146,000 3,083,000 3,343,000 3,611,000 3,909,000 4,333,000 4,770,000 5,278,000 5,823,000 6,217,000 6,472,000 6,789,000 6,675,000 7,161,000 5,868,000 5,035,000 4,139,000 2,943,000 2,884,000 2,711,000 2,675,000 2,893,000 2,823,000 2,962,000 2,512,000 1,942,000 1,722,000 
        total assets
      418,434,000 360,264,000 384,508,000 406,888,000 271,555,000 293,319,000 307,757,000 205,182,000 228,342,000 239,889,000 256,919,000 281,796,000 256,067,000 277,626,000 301,427,000 315,938,000 238,865,000 253,771,000 264,450,000 278,908,000 297,925,000 199,935,000 210,214,000 220,841,000 228,750,000 238,827,000 246,372,000 
        liabilities and stockholders’ equity
                                 
        current liabilities:
                                 
        accounts payable
      4,939,000 5,871,000 4,313,000 2,186,000 2,498,000 2,485,000 3,945,000 2,102,000 1,695,000 3,076,000 1,556,000 4,299,000 766,000 1,911,000 3,602,000 3,328,000 2,385,000 655,000 963,000 1,496,000 1,495,000 1,095,000 904,000 1,779,000 751,000 1,789,000 1,238,000 
        accrued and other current liabilities
      41,035,000 30,093,000 25,616,000 24,335,000 18,567,000 15,768,000 14,500,000 12,570,000 13,815,000 13,390,000 12,222,000 13,777,000 15,748,000 14,046,000 13,413,000 11,108,000 14,754,000 11,229,000 7,234,000 4,614,000 9,930,000 5,640,000 4,901,000 3,676,000 3,350,000 3,127,000 3,580,000 
        deferred revenue - current portion
      11,901,000 5,763,000 8,749,000 18,164,000 18,991,000 31,612,000 26,051,000 20,918,000 15,309,000 8,735,000 8,059,000 13,451,000 14,880,000 12,838,000 10,634,000 8,469,000            
        total current liabilities
      57,875,000 41,727,000 38,678,000 44,685,000 40,056,000 49,865,000 44,496,000 35,590,000 30,819,000 25,201,000 21,837,000 31,527,000 31,394,000 28,795,000 27,649,000 22,905,000 17,139,000 11,884,000 8,197,000 6,110,000 11,425,000 6,735,000 5,805,000 5,455,000 4,101,000 4,916,000 4,818,000 
        deferred revenue - net of current portion
      6,961,000 8,558,000 9,632,000 10,255,000  8,291,000 16,946,000 25,042,000 33,074,000 40,730,000 43,258,000 34,144,000 36,856,000 41,078,000 45,210,000 49,545,000            
        other long term liabilities
      1,141,000 1,874,000 1,255,000 1,874,000 2,478,000 3,050,000 3,606,000 4,208,000 4,884,000 959,000 1,629,000 2,303,000 2,968,000 3,610,000 4,247,000 3,511,000            
        total long term liabilities
      8,102,000 10,432,000 10,887,000 12,129,000 2,478,000 11,341,000 20,552,000 29,250,000 37,958,000 41,689,000 44,887,000 36,447,000 39,824,000 44,688,000 49,457,000 53,056,000            
        total liabilities
      65,977,000 52,159,000 49,565,000 56,814,000 42,534,000 61,206,000 65,048,000 64,840,000 68,777,000 66,890,000 66,724,000 67,974,000 71,218,000 73,483,000 77,106,000 75,961,000 21,088,000 16,258,000 9,381,000 6,443,000 11,847,000 7,400,000 6,814,000 6,499,000 4,322,000 5,144,000 4,836,000 
        commitments and contingencies
                                 
        stockholders’ equity
                                 
        common stock
      5,000 5,000 5,000 5,000 5,000 5,000 5,000 5,000 5,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000 3,000 3,000 3,000 3,000 3,000 3,000 
        additional paid-in capital
      849,624,000 747,435,000 736,276,000 728,124,000 719,997,000 712,290,000 696,637,000 568,560,000 561,433,000 548,033,000 540,919,000 534,111,000 483,170,000 477,337,000 470,977,000 461,389,000 414,024,000 409,166,000 404,145,000 399,532,000 396,352,000 288,249,000 285,430,000 283,413,000 282,460,000 281,555,000 280,804,000 
        accumulated other comprehensive income
      543,000 446,000 96,000   166,000                      
        accumulated deficit
      -497,715,000 -439,781,000 -401,434,000 -377,951,000 -490,830,000 -480,348,000 -453,918,000 -428,223,000 -401,849,000 -374,891,000 -350,349,000 -319,695,000 -297,150,000 -271,495,000 -245,384,000 -220,732,000 -196,083,000 -171,635,000 -149,038,000 -127,071,000 -110,278,000 -95,717,000 -82,033,000 -69,074,000 -58,035,000 -47,875,000 -39,271,000 
        total stockholders’ equity
      352,457,000 308,105,000 334,943,000 350,074,000 229,021,000 232,113,000 242,709,000 140,342,000 159,565,000 172,999,000 190,195,000 213,822,000 184,849,000 204,143,000 224,321,000 239,977,000 217,777,000 237,513,000 255,069,000 272,465,000 286,078,000 192,535,000 203,400,000 214,342,000 224,428,000 233,683,000 241,536,000 
        total liabilities and stockholders’ equity
      418,434,000 360,264,000 384,508,000 406,888,000 271,555,000 293,319,000 307,757,000 205,182,000 228,342,000 239,889,000 256,919,000 281,796,000 256,067,000 277,626,000 301,427,000 315,938,000 238,865,000 253,771,000 264,450,000 278,908,000 297,925,000 199,935,000 210,214,000 220,841,000 228,750,000 238,827,000 246,372,000 
        marketable securities - current
       164,916,000 146,236,000 82,507,000  89,184,000                      
        restricted cash - current
        75,000 75,000  75,000                      
        marketable securities - long-term
       80,315,000 107,256,000 22,989,000  29,952,000                      
        restricted cash - long-term
       721,000 721,000 721,000  494,000 494,000                     
        accumulated other comprehensive loss
         -104,000 -151,000  -15,000  -24,000 -147,000 -379,000 -598,000 -1,175,000 -1,703,000 -1,276,000 -684,000 -168,000 -22,000 -42,000         
        marketable securities
            88,506,000  9,952,000 24,741,000 39,387,000 63,334,000 116,039,000 138,259,000 207,876,000 209,105,000 74,915,000 87,118,000 82,156,000         
        restricted cash - short-term
            75,000           147,000 147,000 147,000        
        deferred financing costs
             402,000         117,000 117,000 117,000 117,000 181,000 378,000 77,000     
        restricted cash
             569,000 569,000 569,000 569,000 569,000 569,000 569,000 569,000 569,000 569,000 569,000 75,000 58,000 205,000 205,000 205,000 205,000 205,000 205,000 205,000 
        prepaid expenses and other current assets
                   12,551,000 13,179,000 12,290,000 9,159,000 8,468,000 8,612,000 7,511,000 6,435,000 3,615,000 3,528,000 4,342,000 3,281,000 3,255,000 1,505,000 
        long term liabilities
                      3,949,000 4,374,000 1,184,000 333,000 422,000 665,000 1,009,000 1,044,000 221,000 228,000 18,000 
        preferred stock, par value of 0.0001 per share; 10,000,000 shares authorized, none issued and outstanding as of december 31, 2019; and no shares authorized, issued or outstanding as of december 31, 2018
                                 
        convertible preferred stock, par value of 0.0001 per share; no shares authorized, issued or outstanding at december 31, 2019; 225,584,874 shares authorized, 22,677,585 shares issued and outstanding as of december 31, 2018, aggregate liquidation preference of 130,850 at december 31, 2018
                                 
        preferred stock, par value of 0.0001 per share; 10,000,000 shares authorized, none issued and outstanding as of september 30, 2019; and no shares authorized, issued or outstanding as of december 31, 2018
                                 
        convertible preferred stock, par value of 0.0001 per share; no shares authorized, issued or outstanding at september 30, 2019; 22,677,585 shares issued and outstanding as of december 31, 2018; aggregate liquidation preference of 130,850 at december 31, 2018
                                 
        preferred stock, par value of 0.0001 per share; 10,000,000 shares authorized, none issued and outstanding as of june 30, 2019; and none authorized as of december 31, 2018
                                 
        convertible preferred stock, par value of 0.0001 per share; no shares authorized, issued or outstanding at june 30, 2019; 22,677,585 shares issued and outstanding as of december 31, 2018; aggregate liquidation preference of 130,850 at december 31, 2018
                                 
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 
                                  
          cash flows from operating activities:
                                  
          net loss
            -10,482,000 -26,430,000 -25,695,000 -26,374,000 -26,958,000 -24,542,000 -30,654,000 -22,545,000 -25,655,000 -26,111,000 -24,652,000 -24,649,000 -24,448,000 -22,597,000 -21,967,000 -16,793,000 -14,561,000 -13,684,000 -12,959,000 -11,039,000 -10,160,000 -8,604,000 
          adjustments to reconcile net loss to net cash from operating activities:
                                  
          depreciation
        405,000 442,000 446,000 477,000 526,000 540,000 548,000 563,000 624,000 637,000 611,000 597,000 609,000 388,000 302,000 247,000 235,000 254,000 249,000 236,000 237,000 234,000 224,000 193,000 139,000 126,000 
          amortization and accretion of marketable securities
        -551,000 -615,000 527,000 -494,000 -782,000 -547,000 -289,000 -24,000 -89,000 -122,000 -146,000 32,000 -151,000 -102,000 -193,000 235,000 57,000 49,000         
          stock-based compensation
        9,848,000 8,039,000 7,598,000 6,753,000 7,139,000 7,494,000 7,427,000 5,410,000 6,058,000 6,552,000 6,760,000 5,887,000 5,790,000 5,926,000 6,163,000 4,975,000 4,686,000 4,614,000 4,452,000 2,698,000 1,580,000 1,785,000 1,649,000 754,000 712,000 731,000 
          impairment of right of use asset
                                 
          loss on disposal of property and equipment
        153,000               29,000 3,000   
          reduction in the carrying amount of right of use assets
        650,000 547,000 612,000 599,000 582,000 571,000 562,000 550,000 591,000 563,000 556,000 550,000 543,000 536,000 533,000 377,000 386,000 322,000 277,000 271,000 266,000 262,000 257,000 253,000   
          changes in assets and liabilities:
                                  
          accounts receivable
        3,312,000                          
          prepaid expenses and other current assets
        220,000 5,640,000 -3,850,000 -2,555,000 -1,443,000 600,000 -644,000 -349,000 1,353,000 -514,000 1,778,000 -2,088,000 -1,528,000 581,000 -971,000 -3,265,000 -778,000 228,000 -1,223,000 -1,078,000 -2,823,000 -80,000 949,000 -924,000 863,000 -1,866,000 
          accounts payable, accrued liabilities, and operating leases
                                  
          deferred revenue
        4,541,000 -4,060,000 -10,038,000 9,427,000 -20,912,000 -3,094,000 -2,963,000 -2,423,000 -1,079,000 -1,854,000 3,722,000 -4,140,000 -2,180,000 -1,928,000 -2,170,000 58,014,000           
          net cash from operating activities
        -30,454,000 -30,366,000 -25,422,000 131,827,000 -23,193,000 -21,615,000 -17,477,000 -24,566,000 -20,649,000 -17,262,000 -21,800,000 -21,356,000 -22,373,000 -22,056,000 -19,928,000 32,491,000 -16,258,000 -14,682,000 -15,831,000 -20,136,000 -10,931,000 -10,873,000 -9,646,000 -10,771,000 -10,201,000 -8,048,000 
          capital expenditures
        -232,000 -132,000 -154,000 -152,000 -42,000 -103,000 -46,000 -12,000 -229,000 -383,000 -839,000 -165,000 -409,000 -2,030,000 -682,000 -841,000 -203,000 -273,000 -520,000 -204,000 -90,000 -269,000 -81,000 -610,000 -568,000 -583,000 
          free cash flows
        -30,686,000 -30,498,000 -25,576,000 131,675,000 -23,235,000 -21,718,000 -17,523,000 -24,578,000 -20,878,000 -17,645,000 -22,639,000 -21,521,000 -22,782,000 -24,086,000 -20,610,000 31,650,000 -16,461,000 -14,955,000 -16,351,000 -20,340,000 -11,021,000 -11,142,000 -9,727,000 -11,381,000 -10,769,000 -8,631,000 
          cash flows from investing activities:
                                  
          purchases of property and equipment
        -232,000 -132,000 -154,000 -152,000 -42,000 -103,000 -46,000 -12,000 -229,000 -383,000 -839,000 -165,000 -409,000 -2,030,000 -682,000 -841,000 -203,000 -273,000 -520,000 -204,000 -90,000 -269,000 -81,000 -610,000 -568,000 -583,000 
          purchases of marketable securities
        -98,228,000 -23,925,000 -181,553,000 -19,016,000 -29,139,000 -49,901,000       4,870,000 -9,706,000 -52,543,000 -143,941,000 -4,991,000         
          sales of marketable securities
        37,399,000 33,151,000 33,230,000 32,800,000 30,000,000 20,000,000 10,000,000 15,000,000 15,000,000 24,312,000 53,250,000 18,029,000 79,000,000 53,371,000 9,000,000           
          net cash from investing activities
        -61,061,000 9,094,000 -148,477,000 13,632,000 819,000 -30,004,000 -88,278,000 9,988,000 14,771,000 14,617,000 23,473,000 53,085,000 22,490,000 67,264,000 146,000 -135,782,000 11,797,000 -5,264,000 -82,755,000 -204,000 -90,000 -269,000 -81,000 -610,000 -569,000 -583,000 
          cash flows from financing activities:
                                  
          proceeds from issuance of common stock upon exercise of stock options
        4,557,000 2,488,000 554,000 1,004,000 567,000 139,000 766,000 250,000 4,000 214,000 -5,000 158,000 42,000 33,000 326,000 93,000 172,000 73,000 161,000 371,000 1,595,000 681,000 368,000 199,000  19,000 
          proceeds from employee stock purchase plan
        632,000 370,000 364,000 168,000 1,000 348,000 53,000 153,000 401,000 169,000 334,000 175,000      
          proceeds from controlled equity offering sales agreement, net of commissions
                                  
          proceeds from follow-on offering, net of underwriting discounts, commissions and offering costs
                                
          net cash from financing activities
        92,341,000 3,120,000 554,000 1,374,000 568,000 8,159,000 120,650,000 1,717,000 7,343,000 562,000 48,000 45,054,000 43,000 434,000 3,425,000 42,507,000 171,000 408,000 159,000 546,000 106,868,000 673,000 369,000 198,000 192,000 -1,000,000 
          net decrease in cash, cash equivalents and restricted cash
        826,000            160,000 45,642,000 -16,357,000 -60,784,000  -19,538,000      -11,183,000   
          cash, cash equivalents and restricted cash—beginning of year
                                  
          cash, cash equivalents and restricted cash—end of year
                                  
          supplemental disclosure of non-cash investing and financing activities:
                                  
          right-of-use assets recognized in exchange for operating leases
                                
          property and equipment included in accrued expense and accounts payable
        390,000 41,000 24,000 27,000 50,000   6,000    545,000 -285,000 -348,000 453,000 301,000 1,229,000   97,000 -70,000 36,000 5,000 35,000   
          net income
         -38,348,000 -23,482,000 112,879,000                       
          adjustments to reconcile net income to net cash from operating activities:
                                  
          accounts payable, accrued liabilities and lease liabilities
         4,881,000 2,765,000 4,741,000  -749,000 3,577,000 -1,919,000                   
          proceeds from issuance of common stock in controlled equity offering sales agreements
             7,656,000                     
          cash, cash equivalents and restricted cash—beginning of period
         -1,000 128,780,000  192,011,000  114,125,000  145,464,000  287,513,000  222,676,000  
          cash, cash equivalents and restricted cash—end of period
         -18,153,000 -173,345,000 275,613,000  -43,460,000 14,895,000 179,150,000  -2,083,000 1,721,000 190,908,000  45,642,000 -16,357,000 84,680,000  -19,538,000 -98,427,000 267,719,000  -10,469,000 -9,358,000 211,493,000  -9,631,000 
          net increase in cash, cash equivalents and restricted cash
          -173,345,000 146,833,000 -21,806,000 -43,460,000 14,895,000 -12,861,000 1,465,000 -2,083,000 1,721,000 76,783,000        -19,794,000 95,847,000 -10,469,000   -10,578,000 -9,631,000 
          deferred offering costs not yet paid
               402,000             145,000 -60,000     
          proceeds from controlled equity offering sales agreements
               1,299,000   44,743,000              
          proceeds from controlled equity offering sales agreement
                7,338,000       42,245,000           
          other
                                  
          accounts payable and accrued liabilities
                 2,017,000 -4,427,000 351,000 199,000 -1,346,000 1,060,000 -3,443,000 3,604,000 2,448,000 2,344,000 -5,499,000 4,370,000 610,000 234,000 -11,000 -1,761,000 1,557,000 
          proceeds from issuance of common stock upon public offerings
                                  
          payment of offering costs
                                  
          deferred financing costs
                            181,000      
          right-of-use assets recognized in exchange for operating leases under topic 842
                                  
          payments of follow-on offering costs
                         1,000         
          right of use asset recognized in exchange for operating lease
                                  
          right-of-use assets recognized in exchange for operating leases upon adoption of topic 842
                            2,153,000   
          right-of-use asset recognized upon entering into amended lease
                                  
          payments on capital lease
                               -1,000   
          deferred rent
                                6,000 8,000 
          proceeds from sale of property and equipment
                                -1,000 
          proceeds from the issuance of common stock upon initial public offering
                                 
          payments of initial public offering costs
                                -1,020,000 
          proceeds from issuance of convertible preferred stock
                                  
          preferred stock issuance cost
                                  
          proceeds from issuance of common stock upon initial public offering
                                  
          proceeds from exercise of stock options
                                  
          property and equipment included in accrued expenses and accounts payable
                                  
          issuance of convertible preferred stock in exchange for simple agreement for future equity
                                  
          gain/loss on disposal of property and equipment