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Sorrento Therapeutics, Inc
(NASDAQ:SRNE) 

SRNE stock logo

Sorrento Therapeutics, Inc., a clinical stage and commercial biopharmaceutical company, develops therapies for cancer, autoimmune, inflammatory, viral, and neurodegenerative diseases. It operates through two segments, Sorrento Therapeutics and Scilex. The company provides cancer therapeutics by leve...

Founded: 1989
Full Time Employees: 502 (May 2021)
Sector: Healthcare
Industry: Biotechnology

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At a glance:
Bull Thesis:
Bear Thesis:
Main Competitors:
Moat:
Income Statements:
Quarterly
Annual
    Unit: USD2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 
                       
      revenues:
                       
      net product revenues
    12,605,000 10,597,000 12,765,000 13,649,000 8,591,000 9,990,000 6,296,000 7,562,000 7,854,000 7,023,000 7,712,000 7,874,000 5,794,000 5,248,000 2,967,000 3,810,000    
      service revenues
    2,420,000 5,654,000 2,829,000 3,751,000 2,870,000 8,395,000 6,780,000 4,500,000 5,657,000 7,232,000 3,793,000 3,879,000 3,213,000 2,473,000 1,632,500 1,968,000    
      total revenues
    15,025,000 16,251,000 15,594,000 17,400,000 11,461,000 18,385,000 13,076,000 12,062,000 13,511,000 14,255,000 11,505,000 11,753,000 9,007,000 7,721,000 4,599,500 5,778,000 6,477,000 6,143,000  
      yoy
    31.10% -11.61% 19.26% 44.25% -15.17% 28.97% 13.65% 2.63% 50.01% 84.63% 150.14% 103.41% 39.06% 25.69%      
      qoq
    -7.54% 4.21% -10.38% 51.82% -37.66% 40.60% 8.41% -10.72% -5.22% 23.90% -2.11% 30.49% 16.66% 67.87% -20.40% -10.79% 5.44%   
      operating costs and expenses:
                       
      cost of products sold
    6,564,000 3,881,000 3,909,500 7,283,000 3,393,000 2,878,000 637,250 1,172,000 525,000 852,000 449,000 549,000 699,000 548,000 967,000 2,839,000    
      cost of services
    1,889,000 1,305,000 447,000 985,000 2,311,000 2,880,000 1,835,000 2,215,000 2,596,000 2,534,000 2,228,000 2,122,000 1,550,000 1,891,000 -643,000 2,387,000    
      research and development
    33,271,000 43,805,000 41,044,000 67,989,000 48,467,000 63,977,000 59,135,000 49,448,000 54,506,000 43,833,000 34,033,000 32,003,000 24,150,000 21,154,000 28,963,000 27,573,000 24,759,000 25,584,000  
      acquired in-process research and development
         12,272,000 600,000 11,125,000 4,971,000 7,512,000 3,227,000 34,884,000 4,881,000     75,301,000  
      selling, general and administrative
    48,941,000 54,980,000 39,464,000 50,159,000 48,136,000 44,327,000 54,580,000 48,489,000 50,393,000 43,394,000 41,152,000 24,265,000 24,463,000 26,299,000 25,429,000 25,234,000 27,772,000   
      intangible amortization
    1,127,000 1,127,000 1,129,000 1,127,000 1,035,000 1,034,000 1,035,000 1,000,000 1,070,000 1,035,000 1,035,000 1,034,000 992,000 992,000 992,000 991,000 992,000 966,000  
      increase on contingent consideration
     3,800,000 -8,300,000 -700,000 -64,300,000               
      loss on impairment of intangible assets
    466,000 11,900,000 33,410,000  90,780,000               
      legal settlement
     1,797,000                  
      total operating costs and expenses
    92,258,000 122,595,000 185,221,000 126,843,000 129,822,000 125,268,000 127,685,000 113,449,000 114,061,000 99,160,000 82,028,000 94,857,000 56,735,000 50,884,000 45,613,000 59,061,000 56,838,000 129,313,000  
      income from operations
    -77,233,000 -106,344,000 -169,627,000 -109,443,000 -118,361,000 -106,883,000 -114,609,000 -101,387,000 -100,550,000 -84,905,000 -70,523,000 -83,104,000 -47,728,000 -43,163,000 -32,579,000 -53,283,000 -50,361,000 -123,170,000  
      yoy
    -34.75% -0.50% 48.00% 7.95% 17.71% 25.89% 62.51% 22.00% 110.67% 96.71% 116.47% 55.97% -5.23% -64.96%      
      qoq
    -27.37% -37.31% 54.99% -7.53% 10.74% -6.74% 13.04% 0.83% 18.43% 20.39% -15.14% 74.12% 10.58% 32.49% -38.86% 5.80% -59.11%   
      operating margin %
    -514.03% -654.38% -1087.77% -628.98% -1032.73% -581.36% -876.48% -840.55% -744.21% -595.62% -612.98% -707.09% -529.90% -559.03% -708.32% -922.17% -777.54% -2005.05%  
      gain on derivative liabilities
    -20,000 -1,280,000 2,016,000 500,000 -2,700,000 7,500,000 -400,000 -1,800,000 -300,000 2,200,000 700,000 -1,000,000 1,980,000 4,920,000      
      loss on marketable and equity investments
    -1,777,000                   
      loss on debt extinguishment
     -40,000   -471,000 -5,262,000   -584,000 -6,111,000   -28,294,000       
      loss on foreign currency exchange
    157,000 -4,000   -561,000     -540,000       -411,000   
      interest expense
    -2,668,000 -1,132,000 -2,219,000 -792,000 -2,314,000 -3,249,000 -2,942,000 -2,900,000 -2,016,000 -2,366,000 -2,495,000 -2,563,000 -8,297,000 -6,825,000 -8,080,000 -9,459,000 -9,520,000 -9,080,000  
      other loss
    -4,321,000         -78,000          
      reorganization items
    -22,003,000 -20,231,000                  
      loss before income tax
    -107,865,000 -142,790,000 -210,499,000 -91,702,000 -220,599,000  -178,068,000 -119,773,000 -167,340,000  -73,068,000 -86,398,000 -82,213,000 -68,900,000 -69,110,000 -74,002,000 -70,654,000 -145,810,000  
      income tax expense
    671,000 11,468,000   -1,050,000 1,463,000 -115,250 386,000   -512,500 145,000        
      gain on equity method investments
      750 62,000 72,000  -69,250 164,000            
      net income
    -108,536,000 -154,626,000 -227,114,000 -90,625,000 -219,477,000 -40,540,000 -144,862,000 -119,995,000 -166,699,000 2,418,000 -73,127,000 -87,109,000 -84,993,000 -69,180,000 -69,426,000 -75,212,000 -71,845,000 -146,529,000  
      yoy
    -50.55% 281.42% 56.78% -24.48% 31.66% -1776.59% 98.10% 37.75% 96.13% -103.50% 5.33% 15.82% 18.30% -52.79%      
      qoq
    -29.81% -31.92% 150.61% -58.71% 441.38% -72.01% 20.72% -28.02% -6994.09% -103.31% -16.05% 2.49% 22.86% -0.35% -7.69% 4.69% -50.97%   
      net income margin %
    -722.37% -951.49% -1456.42% -520.83% -1914.99% -220.51% -1107.85% -994.82% -1233.80% 16.96% -635.61% -741.16% -943.63% -896.00% -1509.42% -1301.70% -1109.23% -2385.30%  
      net loss attributable to noncontrolling interests
    -13,324,000  -3,422,000 -1,049,000 -718,000  -445,000 -192,000 -84,000 -92,000 -1,625,000 -3,086,000 -7,253,000 -3,985,000 -16,084,500 -10,797,000 -15,083,000 -38,458,000  
      net loss attributable to sorrento
    -95,212,000 -139,616,000 -223,692,000 -89,576,000 -218,759,000  -144,417,000 -119,803,000 -166,615,000  -71,502,000 -84,023,000 -77,740,000 -65,195,000 -57,312,000 -64,415,000 -56,762,000 -108,071,000  
      net income per share
    -0.17 -0.26 -0.49 -0.2 -0.54 -0.12 -0.47 -0.4 -0.57 0.01 -0.25 -0.33 -0.36 -0.36 -0.37 -0.49 -0.46 -0.88  
      weighted-average shares used for eps calculation
    551,281 543,137  451,621 402,801 337,123  299,276 290,003 280,604  251,211 216,956 182,609  130,800 122,549 122,281  
      gain on marketable and equity investments
     -13,683,000                  
      other income
     -76,000 1,345,000 74,000 -700,000 17,000 13,250 97,000 34,000  -1,557,000 238,000        
      loss on equity method investments
     -368,000    -131,000   -22,000 -419,000 -23,000 -566,000 -4,699,000 -556,000 -7,000 -1,431,000 -1,574,000 -897,000  
      net income attributable to noncontrolling interests
     -15,010,000    275,000              
      gain on marketable investments
      -10,760,500 -16,084,000 -95,492,000 68,534,000 4,261,750 -13,483,000            
      gain on debt extinguishment
      -692,000 33,433,000                
      gain on foreign currency exchange
      111,250 610,000  397,000 -132,000 -300,000 -1,000  805,000 30,000 124,000 -147,000 -154,750 -521,000  313,000  
      income tax benefit
      -1,814,000 -1,015,000     -641,000 -206,000   -1,919,000 -276,000 309,000 -221,000 -383,000 -178,000  
      gain on contingent consideration
         -2,100,000              
      income before income tax
         -38,946,000    2,212,000          
      net income attributable to sorrento
         -40,815,000    2,510,000          
      gain on marketable investment
            -63,901,000 94,431,000          
      interest income
              2,000 1,000 2,000 19,000 70,000 182,000 305,000 534,000  
      gain on trading securities
                 -59,000   -76,000 94,000  
      loss on partial debt settlement
                 -23,645,000      
      loss on contingent liabilities and acquisition consideration payable
                  -11,193,000 37,000 34,000   
      loss on trading securities
                   -221,000    
      loss on derivative liabilities
                  -8,948,000 -10,700,000 -10,591,000   
      royalty and license
                    120,000 120,000  
      sales and services
                    6,357,000 6,023,000  
      costs of revenues
                    3,281,000 2,308,000  
      general and administrative
                     25,122,000  
      loss on contingent liabilities
                     32,000  
      loss on derivative liability
                     -14,501,000  
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 
                         
        current assets:
                         
        cash and cash equivalents
      69,749,000 37,655,000 23,634,000 70,686,000 70,345,000 111,906,000 36,665,000 39,735,000 77,291,000 41,678,000 56,464,000 75,176,000 24,388,000 21,897,000 22,521,000 34,649,000 61,385,000 90,971,000 158,738,000 
        marketable investments
      10,886,000 12,662,000 26,344,000 47,175,000 63,259,000 158,751,000 90,217,000 122,934,000            
        accounts receivables
      32,725,000 26,524,000 24,469,000 24,190,000 24,715,000 24,674,000 18,715,000 16,454,000 22,437,000 16,309,000 15,506,000 14,768,000 13,801,000 10,023,000 14,454,000 11,560,000    
        inventory
      9,651,000 11,308,000 9,976,000 17,961,000 20,697,000 14,086,000 8,106,000 5,427,000 2,684,000 1,779,000 1,831,000 2,144,000 2,447,000 3,038,000 3,362,000 4,335,000 6,631,000 4,568,000  
        prepaid expenses
      5,222,000 7,827,000 8,807,000 7,937,000 8,960,000 13,558,000 11,804,000 12,196,000 11,656,000 7,656,000 8,712,000         
        other current assets
      4,878,000 4,784,000 3,143,000 9,008,000 8,072,000 8,140,000 7,482,000 3,974,000 6,784,000 3,848,000 3,721,000         
        total current assets
      133,111,000 100,760,000 96,373,000 176,957,000 196,048,000 331,115,000 172,989,000 200,720,000 155,262,000 265,701,000 86,234,000 105,988,000 55,001,000 49,632,000 67,588,000 67,568,000 93,506,000 118,579,000 179,564,000 
        property and equipment
      53,237,000 54,861,000 51,971,000 43,634,000 42,530,000 41,705,000 41,325,000 45,750,000 45,991,000 34,681,000 31,861,000 29,454,000 27,523,000 28,470,000 29,888,000 30,338,000 30,829,000 28,900,000 24,384,000 
        operating lease right-of-use assets
      53,408,000 85,398,000 86,464,000 85,261,000 86,094,000 84,894,000 85,173,000 76,674,000 37,769,000 39,011,000 42,052,000 44,833,000 45,070,000 46,329,000 46,384,000 47,799,000 46,686,000 43,292,000  
        intangibles
      122,283,000 123,875,000 136,902,000 171,440,000 172,566,000 258,671,000 259,705,000 320,970,000 322,005,000 72,640,000 73,675,000 79,967,000 61,324,000 62,316,000 63,308,000 64,299,000 64,825,000 65,817,000 66,283,000 
        goodwill
      80,269,000 80,269,000 80,269,000 80,199,000 81,351,000 79,525,000 79,525,000 52,892,000 52,892,000 43,554,000 43,554,000 38,298,000 38,298,000 38,298,000 38,298,000 38,298,000 38,298,000 38,298,000 38,298,000 
        equity investments
      12,008,000 12,008,000 17,176,000 55,605,000 50,739,000 50,667,000 51,271,000 51,120,000 162,956,000 155,979,000 256,397,000 256,420,000        
        other assets
      2,376,000 2,892,000 3,685,000 2,518,000 2,804,000 9,059,000 4,830,000 4,664,000 2,049,000 2,049,000 2,049,000         
        total assets
      456,692,000 460,063,000 472,840,000 615,614,000 632,132,000 855,636,000 694,818,000 752,790,000 778,924,000 613,615,000 535,822,000 602,085,000 533,068,000 536,553,000 557,632,000 560,875,000 587,043,000 609,474,000 624,087,000 
        liabilities and stockholders’ equity
                         
        current liabilities:
                         
        accounts payable
      18,554,000 14,590,000 47,515,000 38,391,000 24,937,000 25,018,000 27,414,000 27,839,000 33,969,000 25,060,000 24,706,000 22,849,000 26,605,000 28,986,000 27,630,000 26,750,000 24,886,000 14,652,000 13,817,000 
        accrued payroll and related benefits
      6,964,000 5,314,000 7,884,000 29,197,000 28,394,000 25,391,000 21,503,000 16,674,000 19,112,000 16,286,000 20,859,000 17,930,000 17,909,000 15,507,000  14,665,000 12,500,000 10,159,000  
        accrued expenses and other current liabilities
      91,924,000 68,855,000                  
        accrued legal settlements
        174,752,000                 
        current portion of deferred revenue
      256,000 252,000 652,000 281,000 1,018,000 673,000 1,108,000 2,284,000 2,641,000 1,120,000 4,485,000 4,170,000 4,107,000 3,777,000 3,643,000 3,613,000 3,350,000 3,157,000 2,703,000 
        current portion of operating lease liabilities
      13,051,000 14,050,000 13,880,000 13,373,000 13,508,000 12,451,000 11,539,000 11,644,000 3,936,000 3,734,000 3,626,000 3,687,000 3,460,000 3,374,000 3,322,000 3,018,000 2,401,000 2,534,000  
        current portion of contingent consideration
      397,000 397,000 397,000 397,000 397,000 28,068,000 7,934,000             
        acquisition consideration
      515,000 391,000 7,800,000 7,670,000 7,537,000 7,537,000              
        income tax payable
      12,926,000 12,148,000                  
        current portion of debt
      120,362,000 49,635,000 16,286,000 52,907,000 23,714,000 56,942,000 31,980,000 27,486,000 29,845,000 21,718,000 23,208,000 18,529,000 19,151,000 16,585,000 36,261,000 25,877,000 32,257,000 8,678,000 10,150,000 
        total current liabilities
      264,949,000 165,632,000 327,922,000 201,980,000 145,321,000 204,229,000 139,453,000 175,184,000 180,452,000 96,044,000 96,480,000 92,125,000 91,341,000 90,148,000 115,206,000 112,713,000 111,989,000 74,082,000 61,621,000 
        long-term debt
      21,741,000 21,400,000 19,130,000 17,800,000 83,069,000 96,085,000 110,627,000 83,495,000 82,574,000 79,956,000 92,258,000 149,459,000 147,027,000 182,958,000 199,088,000 234,370,000 223,589,000 229,662,000 223,136,000 
        deferred tax liabilities
      238,000 238,000 591,000 1,744,000 2,358,000 3,512,000 2,426,000 5,083,000 6,002,000 6,699,000 6,918,000 7,055,000 7,055,000 8,893,000 9,043,000 8,634,000 8,923,000 9,230,000 9,416,000 
        deferred revenue
      896,000 983,000 7,098,000 117,224,000 117,445,000 117,667,000 118,942,000 119,206,000 119,209,000 116,926,000 113,185,000 113,477,000 113,781,000 114,085,000 114,389,000 114,783,000 115,192,000 115,501,000 116,274,000 
        derivative liabilities
      1,600,000 1,580,000 300,000  500,000 28,200,000 35,700,000 35,300,000 33,500,000 33,200,000 35,400,000 42,900,000 41,900,000 36,600,000 35,000,000 29,500,000 19,900,000   
        operating lease liabilities
      52,446,000 84,462,000 85,208,000 84,133,000 84,316,000 83,406,000 83,431,000 79,930,000 48,387,000 49,354,000 50,301,000 51,236,000 51,200,000 52,094,000 52,111,000 53,378,000 52,043,000 47,628,000  
        contingent consideration
      550,000 550,000 48,949,000 57,249,000 57,949,000 94,578,000 124,349,000             
        other long-term liabilities
      3,305,000 3,428,000 5,311,000 5,278,000 5,411,000 1,761,000 1,761,000 1,761,000 1,761,000 549,000 549,000 549,000 549,000 549,000 39,000     
        total liabilities not subject to compromise
      345,725,000 278,273,000                  
        liabilities subject to compromise
      308,923,000 309,210,000                  
        total liabilities
      654,648,000 587,483,000 494,509,000 485,408,000 496,369,000 629,438,000 616,689,000 621,463,000 593,389,000 382,728,000 395,091,000 456,801,000 452,853,000 485,327,000 524,876,000 554,206,000 532,427,000 491,361,000 416,587,000 
        commitments and contingencies
                         
        equity
                         
        sorrento therapeutics, inc. equity
                         
        common stock
      55,000 55,000  47,000 18,000 38,000  31,000 30,000 29,000  28,000 25,000 23,000   13,000 13,000  
        additional paid-in capital
      2,036,331,000 2,021,148,000 1,988,753,000 1,916,794,000 1,826,810,000 1,703,610,000 1,513,758,000 1,421,966,000 1,356,853,000 1,236,195,000 1,172,346,000 1,141,208,000 989,702,000 875,712,000 788,122,000  665,515,000 657,115,000 626,658,000 
        accumulated other comprehensive income
      2,240,000 1,826,000 1,501,000 226,000 837,000 -223,000 1,026,000   445,000 520,000    -270,000  48,000 100,000 15,000 
        accumulated deficit
      -2,194,275,000 -2,099,063,000 -1,959,447,000 -1,735,755,000 -1,646,178,000 -1,427,419,000 -1,386,604,000 -1,242,187,000 -1,122,384,000 -955,769,000 -958,279,000 -886,776,000 -802,753,000 -725,013,000 -659,818,000  -532,583,000 -475,821,000 -367,750,000 
        treasury stock
      -49,464,000 -49,464,000 -49,464,000 -49,464,000 -49,464,000 -49,464,000 -49,464,000 -49,464,000 -49,464,000 -49,464,000 -49,464,000 -49,464,000 -49,464,000 -49,464,000   -49,464,000 -49,464,000 -49,464,000 
        total sorrento therapeutics, inc. stockholders’ deficit
      -205,113,000                   
        noncontrolling interests
      7,157,000 -1,922,000 -3,064,000 -1,642,000 3,740,000 -344,000 -619,000 -174,000 -633,000 -549,000 -24,420,000 -60,156,000 -57,070,000 -49,817,000   -28,913,000 -13,830,000 -1,972,000 
        total deficit
      -197,956,000                   
        total liabilities and stockholders’ equity
      456,692,000 460,063,000  615,614,000 632,132,000 855,636,000  752,790,000 778,924,000 613,615,000  602,085,000 533,068,000 536,553,000   587,043,000   
        total sorrento therapeutics, inc. stockholders’ equity
       -125,498,000  131,848,000 132,023,000 226,542,000  131,501,000 186,168,000 231,436,000  205,440,000 137,285,000 101,043,000   83,529,000   
        total equity
       -127,420,000 -21,669,000 130,206,000 135,763,000 226,198,000 78,129,000 131,327,000 185,535,000 230,887,000 140,731,000 145,284,000 80,215,000 51,226,000   54,616,000 118,113,000 207,500,000 
        liabilities and stockholders' equity
                         
        accrued expenses and liabilities
        58,756,000                 
        common stock, 0.0001 par value...
        52,000    32,000    28,000    18,000    13,000 
        total sorrento therapeutics, inc. stockholders' equity
        -18,605,000    78,748,000    165,151,000       131,943,000 209,472,000 
        total liabilities and equity
        472,840,000    694,818,000    535,822,000        624,087,000 
        accrued expenses
         59,764,000 45,816,000 48,149,000 37,975,000 23,575,000 25,267,000 27,728,000 19,198,000 24,562,000 19,711,000 14,241,000 18,728,000 18,478,000 17,383,000 23,590,000 13,403,000 
        equity:
                         
        current portion of contingent consideration and acquisition consideration payable
             65,682,000 65,682,000           
        contingent consideration and acquisition consideration payable
             121,504,000 121,504,000           
        preferred stock, 0.0001 par value...
                         
        accumulated other comprehensive loss
             1,155,000 1,133,000    -225,000 -215,000      
        marketable investment
              34,410,000 194,431,000          
        acquisition consideration payable
               398,000 398,000 398,000 398,000 398,000 908,000 11,312,000 11,312,000 11,312,000 11,312,000 
        restricted cash
                    13,098,000 9,592,000 9,592,000 9,592,000 9,592,000 
        current portion of derivative liabilities
                   7,280,000 8,800,000 9,000,000 7,900,000   
        prepaid expenses and other
                 13,900,000 14,365,000 14,674,000 14,094,000 7,122,000 5,493,000 5,455,000 6,578,000 
        other
                 2,125,000 3,866,000 4,774,000 4,775,000 5,175,000 5,232,000 5,347,000 5,570,000 
        accumulated other comprehensive gain
                 444,000        
        cost method investments
                  237,008,000 237,008,000 237,008,000 237,008,000 237,008,000 237,008,000 237,008,000 
        equity method investments
                  19,978,000 24,676,000 25,233,000 25,240,000 25,509,000 27,083,000 27,980,000 
        income tax receivable
                    59,000 216,000 303,000 193,000 526,000 
        accrued payroll and related benefit
                    15,914,000     
        marketable securities
                     94,000 316,000 391,000 297,000 
        deferred rent and other
                     828,000 791,000 757,000 6,140,000 
        grants and accounts receivables
                      9,786,000 7,409,000 3,833,000 
        derivative liability
                       14,501,000  
        total liabilities and stockholders' equity
                       609,474,000  
        assets
                         
        accrued payroll and related
                        10,236,000 
        current portion of deferred rent
                         
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 
                          
          net loss
        -108,437,000 -154,626,000 -227,114,000    -144,862,000 -119,995,000   -73,127,000 -87,110,000 -84,993,000 -69,180,000  -75,212,000 -71,845,000 -146,529,000 
          adjustments to reconcile net loss to net cash from operating activities:
                          
          depreciation and amortization
        3,593,000 3,623,000 3,353,000 3,358,000 3,236,000 3,298,000 2,859,000 3,547,000 3,138,000 2,918,000 2,217,000 3,137,000 2,595,000 3,058,000 2,741,000 2,314,000 2,896,000 3,038,000 
          non-cash operating lease cost
        2,121,000 1,304,000 1,233,000 821,000 1,189,000 987,000 798,000 1,565,000 733,000 759,000 900,000 1,113,000 847,000 842,000 984,000 852,000   
          non-cash interest expense and amortization of debt issuance costs
        403,000 776,000 1,410,000 490,000 1,986,000 2,906,000 3,263,000 1,889,000 1,912,000 2,098,000 2,457,000 2,485,000 3,569,000 4,386,000     
          payment on notes attributed to accreted interest related to the debt discounts
           -15,269,000 -6,788,000             
          acquired in-process research and development
          1,000 12,271,000 600,000 11,084,000 5,012,000 7,512,000 3,227,000 34,884,000       
          loss on write-off of leasehold improvements
                          
          stock-based compensation
        15,194,000 18,282,000 17,230,000 18,501,000 18,324,000 20,792,000 22,679,000 21,103,000 22,746,000 23,660,000 18,107,000 6,295,000 3,335,000 3,682,000 3,670,000 4,015,000 2,987,000 1,976,000 
          loss on debt extinguishment
        40,000 692,000 -33,433,000 470,000 5,262,000 584,000 6,111,000       
          loss on derivative liabilities
        20,000 1,280,000          1,000,000 -1,980,000 -4,920,000  10,700,000   
          loss on marketable and equity investments
                          
          loss on equity method investments
        368,000 18,429,000 -62,000 -72,000 131,000 -151,000 -164,000 22,000 419,000 23,000 566,000 4,699,000 556,000 7,000 1,431,000 1,574,000 897,000 
          write-off obsolete inventory
                          
          change in fair value of convertible notes
                          
          dip facility upfront lender fees and debt issuance costs
        1,312,000 2,725,000                 
          dip facility exit fee
        5,250,000                 
          increase on contingent consideration
        3,800,000                 
          loss on impairment of intangible assets
          33,410,000               
          deferred income taxes
        -353,000 -1,154,000 -11,000 -1,757,000 1,086,000             
          changes in operating assets and liabilities, excluding effect of acquisitions:
                          
          accounts receivable
        -6,209,000 -2,047,000 -278,000 -3,013,000 3,593,000 -5,982,000 -2,260,000 732,000 -626,000 -803,000 -738,000 -968,000 -3,777,000 4,432,000     
          inventory
        -498,000 -1,333,000 -5,014,000 6,879,000 -5,396,000 -5,979,000             
          accrued payroll
        1,639,000 -2,541,000 -21,275,000 844,000 3,040,000 3,949,000 4,830,000 -2,438,000 2,070,000 -4,573,000 2,929,000 21,000 2,402,000 -407,000 1,249,000 2,165,000 2,340,000 -76,000 
          prepaid expenses, deposits and other assets
        3,025,000 131,000 2,149,000 374,000 5,920,000 -1,640,000  -4,036,000 -3,002,000 980,000  2,976,000 1,427,000 185,000     
          accounts payable
        6,909,000 18,233,000 4,160,000 4,283,000 3,998,000 -2,571,000 -329,000 -6,485,000 3,012,000 -76,000 4,879,000 -7,315,000 -1,969,000 728,000 1,439,000 3,127,000 9,094,000 -3,439,000 
          accrued expenses and other liabilities
        19,617,000 16,357,000 -800,000 16,804,000 -5,146,000 9,122,000 -14,842,000 29,850,000 -5,327,000 11,066,000 -2,732,000 1,471,000 4,561,000 -4,488,000 924,000 686,000 -6,208,000 8,659,000 
          deferred revenue
        -202,000 563,000 -109,756,000 -957,000 122,000 -1,709,000 -1,441,000 -359,000 400,000 376,000 23,000 -241,000 25,000 -169,000 -364,000 -146,000 -116,000 -319,000 
          accrued legal settlements
        1,797,000                 
          income tax payable
                          
          other
        -3,457,000 -518,000   -421,000 179,000 -3,913,000 -253,000 141,000 476,000 -55,000 -906,000 398,000 -750,000 -531,000 1,000 -261,000 163,000 
          net cash from operating activities
        -55,659,000 -49,459,000 -68,338,000 -61,171,000 -80,988,000 -83,360,000 -72,137,000 -83,112,000 -78,515,000 -48,057,000 -40,869,000 -42,592,000 -37,525,000 -38,550,000 -36,022,000 -45,831,000 -46,834,000 -44,309,000 
          capital expenditures
        -140,000 -86,000 -4,524,000 -3,835,000 -2,705,000 -2,593,000 -2,209,000 -1,175,000 -3,493,000 -1,994,000 -2,688,000 -2,870,000 -949,000 -21,000 -1,860,000 -2,094,000 -2,260,000 -5,228,000 
          free cash flows
        -55,799,000 -49,545,000 -72,862,000 -65,006,000 -83,693,000 -85,953,000 -74,346,000 -84,287,000 -82,008,000 -50,051,000 -43,557,000 -45,462,000 -38,474,000 -38,571,000 -37,882,000 -47,925,000 -49,094,000 -49,537,000 
          investing activities
                          
          purchases of property and equipment
        -140,000 -86,000 -4,524,000 -3,835,000 -2,705,000 -2,593,000 -2,209,000 -1,175,000 -3,493,000 -1,994,000 -2,688,000 -2,870,000 -949,000 -21,000 -1,860,000 -2,094,000 -2,260,000 -5,228,000 
          virex health acquisition consideration paid in cash, net of cash acquired
          -6,544,000             
          proceeds received from exit of fortunebio investment
        1,770,000                 
          other acquisitions and investments considerations paid in cash
             -4,527,000             
          net cash from investing activities
          -5,034,000 -8,092,000 -1,728,000 -13,664,000 -2,205,000 5,396,000 78,662,000 -2,006,000 -11,414,000 -25,227,000 -3,261,000 -21,000 -10,389,000 -3,256,000 -2,260,000 -22,268,000 
          financing activities
                          
          proceeds from equity offerings, net of issuance costs
        -2,185,000 22,971,000 62,298,000 71,455,000 104,149,000 164,432,000 66,947,000 41,917,000 50,752,000 42,209,000 104,856,000 63,766,000 79,347,000 69,896,000     
          proceeds from dip facility, net of lender fees and debt issuance costs
        43,688,000 27,275,000                 
          proceeds from other short-term debt, net of issuance costs
        1,952,000 4,907,000                 
          proceeds from issuance of scilex shares
                          
          proceeds from issuance of scilex convertible debentures
        14,400,000 9,600,000                 
          proceeds from scilex ecapital-revolver
                          
          proceeds from exercises of stock options and warrants
          373,000 20,000 673,000 132,000             
          repayments of debt and other obligations
        -1,728,000 -3,557,000 -35,528,000 -41,444,000 -63,023,000 -48,316,000  -15,735,000 -27,758,000 -29,218,000  -966,000 -72,320,000 -59,533,000     
          transaction costs related to business combination
                          
          payments of dividends
                          
          net cash from financing activities
        88,813,000 61,196,000 25,080,000 71,498,000 41,771,000 173,369,000 70,857,000 40,060,000 35,058,000 35,357,000 -11,576,000 117,853,000 43,240,000 24,722,000 37,910,000 22,569,000 19,503,000 -1,097,000 
          net change in cash, cash equivalents and restricted cash
        33,014,000 13,421,000 -48,292,000 2,235,000 -40,945,000 76,345,000 -3,485,000 -37,656,000 35,205,000 -14,706,000 -63,859,000 50,034,000 2,454,000 -13,849,000 -8,501,000 -26,518,000 -29,591,000 -67,674,000 
          net effect of exchange rate changes on cash
        -920,000 600,000 1,240,000 -1,894,000 -616,000 -1,104,000 415,000 100,000 408,000 -80,000 147,000 754,000 -13,000 27,000 -121,000 -218,000 5,000 57,000 
          cash, cash equivalents and restricted cash at beginning of period
        23,634,000 36,665,000 56,464,000 80,769,000 213,330,000 
          cash, cash equivalents and restricted cash at end of period
        32,094,000 37,655,000 -47,052,000 341,000 -41,561,000 111,906,000 -3,070,000 -37,556,000 35,613,000 41,678,000 -63,712,000 50,788,000 2,441,000 66,947,000 -8,622,000 -26,736,000   
          supplemental disclosures:
                          
          cash paid during the period for:
                          
          interest
          508,000 431,000 118,000 116,000 974,000 -2,000 5,000 83,000 271,000 1,579,000 1,569,000     
          income taxes
          60,000 -84,000 53,000            
          professional fees paid for reorganization in operating activities
                          
          supplemental disclosures of non-cash investing and financing activities:
                          
          stock dividends
        -14,282,000                 
          dip facility exit fee incurred but not paid
        5,250,000                 
          virex health acquisition consideration paid in equity
          -1,000 4,435,000             
          deferred consideration for intangible asset acquisition
                        
          bridge loan settlement through atm proceeds
        6,166,000                 
          property and equipment costs incurred but not paid
        1,087,000 5,301,000 6,037,000 -197,000 493,000 457,000 91,000 354,000 -223,000 1,031,000 -924,000 1,307,000 -411,000 628,000 -559,000    
          impairment of in-process research and development
         11,900,000                 
          loss on marketable investments
         13,683,000  16,084,000               
          current income taxes
         11,847,000                 
          net cash from for investing activities
         1,684,000                 
          operating activities:
                          
          scilex notes principal increase
                          
          payments on notes attributed to accreted interest related to the debt discounts
                          
          loss on derivative liability
                         14,501,000 
          loss on contingent consideration
          -8,300,000               
          non-cash inventory adjustments
                          
          investing activities:
                          
          proceeds from sale of marketable investments
              654,000            
          acea acquisition consideration paid in cash, net of cash acquired
                        
          other acquisitions and investments considerations paid in cash, net of cash acquired
          -510,000 -4,257,000               
          financing activities:
                          
          proceeds from short-term debt, net of issuance costs
          -2,489,000 41,467,000 -28,000 57,121,000  12,597,000 10,687,000 11,769,000        
          proceeds from the scilex business combination
                          
          transaction costs paid related to the scilex business combination
                          
          payments related to semnur share exchange
                          
          changes to noncontrolling interests related to the scilex business combination
                          
          scilex shares issued to yorkville pursuant to yorkville purchase agreement
                          
          scilex business combination transaction costs incurred but not paid
                          
          smartpharm acquisition consideration paid in equity
                         
          acea acquisition consideration paid in equity
                        
          right-of-use assets obtained in exchange for new and amended operating lease liabilities
                          
          other acquisitions, license agreements and investments consideration paid in equity
                          
          changes to noncontrolling interests from increased ownership in scilex holding
              23,963,000         
          short-term debt
                         
          (gain) on derivative liabilities
                          
          right-of-use assets, operating leases
                          
          proceeds from sale of marketable investment
                          
          other acquisitions, license agreements and investments paid in equity
               812,000 5,377,000 7,500,000        
          net income
            -219,477,000 -40,540,000    2,418,000         
          gain on derivative liabilities
            2,700,000 -7,500,000  1,800,000 300,000 -2,200,000         
          gain on contingent consideration
            -64,300,000 -2,100,000             
          non-cash additions related to leasehold improvements
                684,000 2,279,000         
          gain on marketable investments
             -68,534,000             
          payment on scilex notes attributed to accreted interest related to the debt discount
              -1,381,000 -1,008,000 -6,235,000 -4,548,000         
          loss loss on derivative liability
                          
          loss on contingent liabilities and acquisition consideration payable
                      -11,193,000 37,000 34,000 32,000 
          prepaid expenses and other current assets
                          
          purchase of assets related to semnur, net of cash acquired
                        
          other acquisitions and investments consideration paid in cash
                          
          proceeds from oaktree term loans, net of issuance costs
                          
          proceeds from short-term debt and working capital funding arrangements, net of issuance costs
                          
          payments of debt and other obligations
                          
          semnur acquisition consideration paid in equity
                         
          semnur acquisition costs incurred but not paid
                         
          conversion of convertible notes
                          
          other loan forgiveness
                          
          reconciliation of cash, cash equivalents and restricted cash within the company's consolidated balance sheets:
                          
          cash and cash equivalents
              -3,070,000 -37,556,000 35,613,000 41,678,000 -18,712,000 50,788,000 2,491,000 21,897,000 -12,128,000    
          restricted cash
                   -50,000 45,050,000 3,506,000    
          cash, cash equivalents, and restricted cash
              -3,070,000 -37,556,000 35,613,000 41,678,000 -63,712,000 50,788,000 2,441,000 66,947,000 -8,622,000    
          deferred tax provision
               -918,000 -697,000 -219,000  -1,839,000 -150,000 409,000 -289,000 -307,000 -186,000 
          payments related to license agreements
                  -8,726,000        
          other acquisitions and investments
               -22,371,000 -12,262,000 -12,000 -32,000       
          proceeds from exercise of stock options and warrants
               1,281,000 1,377,000 10,597,000  55,053,000 29,123,000 13,634,000     
          taxes
                          
          reconciliation of cash, cash equivalents and restricted cash within the company’s consolidated balance sheets:
                          
          gain on marketable investment
                63,901,000 -94,431,000         
          loss on ipr&d impairment
                          
          deferred income tax benefit
                          
          acquisition consideration payable
                          
          proceeds from issuance of scilex notes, net of issuance costs
                          
          proceeds from issuance of convertible notes
                          
          scilex non-cash consideration for regulatory milestone
                          
          other acquisitions and investments paid in equity
                          
          loss on partial debt settlement
                     23,645,000     
          proceeds from short-term debt
                     725,000     
          loss on trading securities
                         
          loss on debt settlement / extinguishment
                          
          non-cash income on cost method investments
                          
          grants and other receivables
                        -2,377,000 -3,575,000 
          proceeds from issuance of common stock
                      43,000    
          payments on bridge loans and scilex notes
                          
          proceeds from 2017 securities purchase agreement, net of issuance costs
                          
          short-term working capital funding arrangements, net of issuance costs
                          
          payment of hercules loan agreement
                          
          scilex consideration for regulatory milestones
                          
          net payments of deferred compensation
                          
          virttu acquisition non-cash consideration
                          
          bdl stock issuance
                          
          non-cash interest expense
                       4,696,000 5,586,000 5,682,000 
          acquisition-related ipr&d
                          
          amortization of debt issuance costs
                       517,000 555,000 518,000 
          prepaid expenses and other
                       829,000 -1,539,000 -2,989,000 
          acquisition consideration payable for scilex
                          
          purchase of assets related to sofusa
                          
          contributions to joint venture
                          
          proceeds from public offering, net of issuance costs
                          
          proceeds from early conditional loan, net of issuance costs
                         
          proceeds from bridge loan for scilex regulatory milestone
                          
          repayment of bridge loan for scilex regulatory milestone
                          
          proceeds from loan agreement
                          
          short-term bridge loan, net of issuance costs
                          
          short-term loan repayment
                       -740,000 
          scilex consideration for regulatory milestone
                          
          payment on scilex notes
                       -783,000 -480,000 -438,000 
          proceeds from exercise of stock options
                       -917,000 1,125,000 81,000 
          interest paid
                          
          bdl non-cash consideration
                          
          semnur-related ipr&d
                        75,301,000 
          gain on trading securities
                        76,000 -94,000 
          amortization of operating lease right-of-use assets
                         1,292,000 
          loss on disposals
                         433,000 
          deposits and other assets
                         406,000 
          purchase of assets related to semnur
                         -17,040,000 
          operating activities
                          
          adjustments to reconcile net loss to net cash from and (used for) operating activities:
                          
          loss on sale of marketable securities
                          
          loss on disposal for property and equipment
                          
          loss on receivable
                          
          (gain) on derivative liability
                          
          loss on contingent liabilities
                          
          changes in operating assets and liabilities; net of dispositions:
                          
          deferred rent and other
                          
          investment in siniwest
                          
          investment in celularity
                          
          purchase of business, net of cash acquired
                          
          purchase of medovex investment
                          
          net borrowings under loan and security agreement
                          
          payments on short term bridge loan
                          
          bridge loan for scilex settlement
                          
          bridge loan for scilex settlement repayment
                          
          proceeds from issuance of scilex notes
                          
          scilex notes issuance of scilex notes
                          
          cash payments for treasury shares
                          
          proceeds from loan and security agreement, net of fees
                          
          payments of debt on retired note
                          
          proceeds from oaktree term loan
                          
          oaktree issuance cost
                          
          scilex acquisition non-cash consideration
                          
          siniwest non-cash consideration
                          
          roger williams medical center non-cash consideration
                          
          investment in immuneoncia
                          
          conversion of 2017 convertible notes