Quarterly
Annual
| Unit: USD | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2017-12-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | 2016-12-31 | 2016-09-30 | 2016-06-30 | 2016-03-31 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cash flows from operating activities: | |||||||||||||||||||||||||||||||||||||||
net income | -60,715,000 | -71,847,000 | -84,846,000 | -94,169,000 | -84,126,000 | -68,063,000 | -72,400,000 | -72,473,000 | -51,146,000 | -44,615,000 | -41,126,000 | -39,194,000 | -35,403,000 | -37,572,000 | -37,169,000 | 96,198,000 | -20,639,000 | -22,910,000 | -27,723,000 | -20,423,000 | -20,437,000 | -17,062,000 | -15,236,000 | -14,000,000 | -12,829,000 | -14,916,000 | -14,302,000 | -18,837,000 | -17,339,000 | -18,387,000 | -19,398,000 | -19,103,000 | -15,089,000 | -13,639,000 | -12,971,000 | -10,815,000 | -14,969,000 | -8,358,000 | -10,330,000 |
adjustments to reconcile net income to net cash from operating activities: | |||||||||||||||||||||||||||||||||||||||
depreciation | 0 | 2,000 | 3,000 | 3,000 | 3,000 | 3,000 | 3,000 | 3,000 | 3,000 | 8,000 | 11,000 | 11,000 | 10,000 | 8,000 | 9,000 | 16,000 | 21,000 | 23,000 | 22,000 | 23,000 | |||||||||||||||||||
accretion of investments | -2,413,000 | -3,211,000 | -3,599,000 | -2,940,000 | -3,058,000 | -3,649,000 | -3,821,000 | -3,659,000 | -3,718,000 | -3,967,000 | |||||||||||||||||||||||||||||
non-cash operating lease expense | 158,000 | 172,000 | 221,000 | 208,000 | 295,000 | 242,000 | 244,000 | 243,000 | 237,000 | 149,000 | 110,000 | 112,000 | 100,000 | 99,000 | 110,000 | 111,000 | 105,000 | 96,000 | 101,000 | 105,000 | 107,000 | 106,000 | 108,000 | ||||||||||||||||
stock-based compensation | 12,082,000 | 13,787,000 | 10,380,000 | 12,297,000 | 11,934,000 | 9,896,000 | 8,899,000 | 8,327,000 | 8,321,000 | 8,065,000 | 6,238,000 | 4,241,000 | 4,362,000 | 3,938,000 | 3,478,000 | 3,929,000 | 3,381,000 | 3,240,000 | 2,767,000 | 2,035,000 | 3,063,000 | 2,130,000 | 1,829,000 | 1,525,000 | 1,550,000 | 1,338,000 | 1,592,000 | 1,472,000 | 1,737,000 | 1,571,000 | 1,421,000 | 1,280,000 | 1,345,000 | 1,448,000 | 1,377,000 | 947,000 | 792,000 | 779,000 | 2,190,000 |
amortization of debt issuance costs | 62,000 | 55,000 | 112,000 | ||||||||||||||||||||||||||||||||||||
benefit from credit losses | |||||||||||||||||||||||||||||||||||||||
changes in operating assets and liabilities: | |||||||||||||||||||||||||||||||||||||||
accounts receivable | -5,949,000 | -3,732,000 | -8,120,000 | ||||||||||||||||||||||||||||||||||||
inventory | -7,183,000 | -12,916,000 | -4,191,000 | ||||||||||||||||||||||||||||||||||||
prepaid expenses and other assets | -4,364,000 | -10,770,000 | 5,992,000 | -10,677,000 | 1,964,000 | -2,854,000 | 3,957,000 | -3,740,000 | -2,440,000 | 2,899,000 | 4,702,000 | -2,744,000 | 9,761,000 | -14,691,000 | 77,000 | 886,000 | -1,697,000 | -660,000 | 1,475,000 | -3,405,000 | 146,000 | -2,530,000 | 10,000 | 2,603,000 | -212,000 | -2,453,000 | 3,817,000 | 63,000 | -225,000 | -2,622,000 | -81,000 | 834,000 | 59,000 | -1,141,000 | -1,549,000 | 314,000 | 219,000 | -613,000 | |
collaboration (payable) receivable | -3,420,000 | -24,503,000 | -7,044,000 | 2,403,000 | |||||||||||||||||||||||||||||||||||
other receivable | -38,000 | -39,000 | 45,000 | -128,000 | 6,075,000 | -3,509,000 | -6,073,000 | ||||||||||||||||||||||||||||||||
other assets | 0 | ||||||||||||||||||||||||||||||||||||||
accounts payable | -3,527,000 | 7,306,000 | -1,579,000 | 6,728,000 | -6,670,000 | 2,759,000 | -1,152,000 | 3,912,000 | -4,930,000 | 2,922,000 | 3,707,000 | -2,764,000 | 676,000 | -1,793,000 | 2,562,000 | 547,000 | 1,498,000 | -2,905,000 | 3,021,000 | -328,000 | 2,004,000 | -7,166,000 | 2,820,000 | -454,000 | 4,355,000 | -2,070,000 | 2,908,000 | -1,740,000 | -2,119,000 | 2,709,000 | 358,000 | 12,000 | -1,006,000 | 434,000 | 366,000 | 365,000 | 612,000 | 349,000 | -403,000 |
accrued expenses and other liabilities | 1,102,000 | 17,903,000 | -2,533,000 | 21,037,000 | -6,844,000 | -6,709,000 | 7,503,000 | 14,160,000 | 2,378,000 | -9,174,000 | 10,966,000 | -3,861,000 | -1,540,000 | 3,856,000 | 638,000 | 1,896,000 | 194,000 | 41,000 | 1,686,000 | 617,000 | 776,000 | -2,512,000 | 548,000 | -3,881,000 | 3,939,000 | -4,017,000 | 810,000 | -287,000 | -360,000 | 811,000 | 1,297,000 | 3,886,000 | 129,000 | -7,000 | 958,000 | 2,177,000 | 422,000 | 1,285,000 | |
net cash from operating activities | -70,535,000 | -87,795,000 | -95,162,000 | -57,388,000 | -62,322,000 | -71,645,000 | -83,548,000 | -41,349,000 | -44,653,000 | -35,371,000 | -39,228,000 | -22,894,000 | -28,544,000 | -40,306,000 | -41,931,000 | 100,709,000 | -24,944,000 | -24,045,000 | -22,589,000 | -15,631,000 | -18,297,000 | -21,407,000 | -15,925,000 | -12,727,000 | -8,529,000 | -12,525,000 | -16,831,000 | -15,043,000 | -18,469,000 | -15,149,000 | -19,870,000 | -12,722,000 | -10,181,000 | -11,800,000 | -12,668,000 | -10,416,000 | -11,448,000 | -6,890,000 | -6,403,000 |
capex | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -14,000 | 0 | 0 | -173,000 | -42,000 | 0 | 0 | 0 | 0 | -55,000 | -73,000 | -133,000 |
free cash flows | -70,535,000 | -87,795,000 | -95,162,000 | -57,388,000 | -62,322,000 | -71,645,000 | -83,548,000 | -41,349,000 | -44,653,000 | -35,371,000 | -39,228,000 | -22,894,000 | -28,544,000 | -40,306,000 | -41,931,000 | 100,709,000 | -24,944,000 | -24,045,000 | -22,589,000 | -15,631,000 | -18,297,000 | -21,407,000 | -15,925,000 | -12,727,000 | -8,529,000 | -12,525,000 | -16,831,000 | -15,057,000 | -18,469,000 | -15,149,000 | -20,043,000 | -12,764,000 | -10,181,000 | -11,800,000 | -12,668,000 | -10,416,000 | -11,503,000 | -6,963,000 | -6,536,000 |
cash flows from investing activities: | |||||||||||||||||||||||||||||||||||||||
purchases of property and equipment | -14,000 | 0 | 0 | -173,000 | -42,000 | 0 | -55,000 | -73,000 | -133,000 | ||||||||||||||||||||||||||||||
purchases of short and long-term investments | -30,440,000 | -91,713,000 | -10,538,000 | -376,314,000 | -13,353,000 | 0 | -167,385,000 | -129,290,000 | -82,723,000 | -81,008,000 | -61,585,000 | ||||||||||||||||||||||||||||
proceeds from sales and maturities of short-term investments | 103,000,000 | 133,600,000 | 104,680,000 | 100,200,000 | 61,750,000 | 67,986,000 | 113,000,000 | 122,800,000 | 154,915,000 | 81,500,000 | 113,250,000 | 72,817,000 | 72,418,000 | 50,448,000 | 45,400,000 | 89,575,000 | 81,500,000 | 37,500,000 | 64,447,000 | 38,500,000 | 17,575,000 | 15,885,000 | 41,722,000 | 21,362,000 | 20,335,000 | 33,380,000 | 34,679,000 | 29,500,000 | 41,750,000 | 24,500,000 | 40,843,000 | 31,985,000 | 37,352,000 | 25,095,000 | 47,895,000 | 30,025,000 | 30,520,000 | 31,857,000 | |
net cash from investing activities | 72,429,000 | 41,887,000 | 94,142,000 | -268,973,000 | 86,847,000 | 61,750,000 | -99,399,000 | -16,290,000 | 40,077,000 | 73,907,000 | 19,915,000 | -137,629,000 | -6,793,000 | -49,948,000 | 8,182,000 | 21,680,000 | -29,228,000 | -78,612,000 | -19,053,000 | 6,596,000 | 12,364,000 | -18,931,000 | 12,752,000 | 15,962,000 | 3,508,000 | 19,284,000 | 12,644,000 | 1,544,000 | 6,921,000 | -36,555,000 | 11,063,000 | 21,331,000 | 8,050,000 | -624,000 | -47,137,000 | ||||
cash flows from financing activities: | |||||||||||||||||||||||||||||||||||||||
proceeds from employee stock purchase plan | -80,000 | 468,000 | 545,000 | 535,000 | 237,000 | 309,000 | 259,000 | 178,000 | 196,000 | 110,000 | 58,000 | 92,000 | 125,000 | 99,000 | 64,000 | 79,000 | 103,000 | 93,000 | 85,000 | 64,000 | 57,000 | 53,000 | 45,000 | 27,000 | 69,000 | 32,000 | 63,000 | 34,000 | 58,000 | ||||||||||
proceeds from stock option exercises | 6,358,000 | 83,000 | 385,000 | 3,139,000 | 2,563,000 | 439,000 | 1,859,000 | 112,000 | 1,592,000 | 1,146,000 | 2,278,000 | 1,396,000 | 7,363,000 | 2,235,000 | 465,000 | 1,606,000 | 825,000 | 881,000 | 1,707,000 | 1,015,000 | 338,000 | 27,000 | 0 | 7,000 | |||||||||||||||
net cash from financing activities | 6,278,000 | 551,000 | 930,000 | 347,425,000 | 3,098,000 | 676,000 | 2,168,000 | 258,483,000 | 1,851,000 | 1,324,000 | 2,474,000 | 163,502,000 | -13,525,000 | 21,720,000 | 557,000 | 109,779,000 | 1,705,000 | 6,020,000 | 960,000 | 138,658,000 | 1,767,000 | 109,001,000 | 54,998,000 | 58,000 | 80,000 | 6,000 | 28,426,000 | 6,145,000 | 9,462,000 | 89,000 | 33,000 | 25,614,000 | 1,004,000 | 48,987,000 | 117,000 | 176,000 | 1,710,000 | -1,232,000 | 53,548,000 |
net decrease cash, cash equivalents and restricted cash | 8,172,000 | ||||||||||||||||||||||||||||||||||||||
cash, cash equivalents and restricted cash—beginning of period | 0 | 0 | 154,300,000 | 0 | 0 | 295,611,000 | 0 | 0 | 74,471,000 | 0 | 0 | 222,080,000 | 0 | 0 | 115,358,000 | 0 | 0 | 24,724,000 | 0 | 0 | 33,985,000 | 0 | 0 | 35,389,000 | |||||||||||||||
cash, cash equivalents and restricted cash —end of period | 8,172,000 | -45,357,000 | 154,210,000 | 27,623,000 | -9,219,000 | 114,832,000 | -2,725,000 | 39,860,000 | 57,632,000 | -48,862,000 | -68,534,000 | 188,888,000 | 3,392,000 | 3,655,000 | 64,501,000 | 2,745,000 | 8,982,000 | 44,744,000 | 3,915,000 | -31,450,000 | 58,332,000 | -5,499,000 | 4,224,000 | 28,196,000 | |||||||||||||||
net increase cash, cash equivalents and restricted cash | -90,000 | 27,623,000 | |||||||||||||||||||||||||||||||||||||
adjustments to reconcile net income to net cash provided provided by operating activities: | |||||||||||||||||||||||||||||||||||||||
non-cash interest income | |||||||||||||||||||||||||||||||||||||||
changes in fair value of derivative liability | 0 | 0 | |||||||||||||||||||||||||||||||||||||
prepaid expenses and other current assets | |||||||||||||||||||||||||||||||||||||||
collaboration payable/receivable | |||||||||||||||||||||||||||||||||||||||
accrued expenses and other current liabilities | |||||||||||||||||||||||||||||||||||||||
proceeds from sales of equipment | 0 | ||||||||||||||||||||||||||||||||||||||
proceeds from maturities of short-term investments | |||||||||||||||||||||||||||||||||||||||
proceeds from issuance of common stock in follow on public offerings | |||||||||||||||||||||||||||||||||||||||
proceeds from issuance of common stock in at-the-market offering | |||||||||||||||||||||||||||||||||||||||
proceeds from purchase and sale agreement | |||||||||||||||||||||||||||||||||||||||
payment on term loan | 2,000 | ||||||||||||||||||||||||||||||||||||||
proceeds from espp | |||||||||||||||||||||||||||||||||||||||
net increase in cash, cash equivalents and restricted cash | 200,844,000 | -2,725,000 | 150,532,000 | 3,392,000 | 3,655,000 | -50,857,000 | 58,887,000 | 2,745,000 | 8,982,000 | 20,020,000 | 24,347,000 | ||||||||||||||||||||||||||||
cash, cash equivalents and restricted cash—beginning of year | |||||||||||||||||||||||||||||||||||||||
cash, cash equivalents and restricted cash—end of year | |||||||||||||||||||||||||||||||||||||||
supplemental schedule of cash flow information: | |||||||||||||||||||||||||||||||||||||||
interest paid | 1,000 | ||||||||||||||||||||||||||||||||||||||
issuance costs in accounts payable and accrued expenses | |||||||||||||||||||||||||||||||||||||||
lease assets recognized upon lease remeasurement | |||||||||||||||||||||||||||||||||||||||
collaboration receivable (payable) | 315,000 | -3,899,000 | |||||||||||||||||||||||||||||||||||||
net (decrease) in cash, cash equivalents and restricted cash | -180,779,000 | ||||||||||||||||||||||||||||||||||||||
amortization of investments | |||||||||||||||||||||||||||||||||||||||
other | 0 | -1,000 | 3,000 | 3,000 | 12,000 | 1,000 | -3,000 | 1,000 | 0 | 0 | 1,000 | 7,000 | 28,000 | -1,000 | |||||||||||||||||||||||||
deferred revenue | 0 | -12,375,000 | -379,000 | -379,000 | -379,000 | -380,000 | -379,000 | -379,000 | -379,000 | -380,000 | -379,000 | -379,000 | -379,000 | -380,000 | -379,000 | -379,000 | 3,807,000 | -305,000 | -305,000 | -305,000 | -305,000 | -305,000 | -305,000 | -305,000 | |||||||||||||||
allocation of proceeds to common stock issued under the incyte share purchase agreement | |||||||||||||||||||||||||||||||||||||||
allocation of proceeds to derivative liability recorded under the incyte share purchase agreement | |||||||||||||||||||||||||||||||||||||||
non-cash interest expense | 0 | 792,000 | 159,000 | 152,000 | -583,000 | 124,000 | 120,000 | 114,000 | 113,000 | 110,000 | 104,000 | 62,000 | |||||||||||||||||||||||||||
proceeds from issuance of common stock in at-the-market stock offering | 0 | 0 | 0 | 0 | 830,000 | ||||||||||||||||||||||||||||||||||
supplemental disclosure of cash flow information: | |||||||||||||||||||||||||||||||||||||||
cash paid for interest | 1,099,000 | 490,000 | 470,000 | 503,000 | 503,000 | 493,000 | 504,000 | 503,000 | 126,000 | ||||||||||||||||||||||||||||||
collaboration receivable | 2,082,000 | 1,065,000 | |||||||||||||||||||||||||||||||||||||
net decrease in cash, cash equivalents and restricted cash | -16,839,000 | -48,862,000 | -68,534,000 | -33,192,000 | 3,915,000 | -5,499,000 | 4,224,000 | -7,193,000 | |||||||||||||||||||||||||||||||
(accretion) and amortization of investments | |||||||||||||||||||||||||||||||||||||||
proceeds from issuance of common stock in direct placement offering | |||||||||||||||||||||||||||||||||||||||
proceeds from term loan agreement | |||||||||||||||||||||||||||||||||||||||
amortization and accretion of short-term investments | |||||||||||||||||||||||||||||||||||||||
purchases of short-term investments | -79,835,000 | -122,366,000 | -42,266,000 | -105,227,000 | -62,944,000 | -59,820,000 | -66,728,000 | -128,587,000 | -19,225,000 | -96,187,000 | -34,938,000 | -35,126,000 | -8,998,000 | -39,266,000 | -20,628,000 | -18,703,000 | -25,992,000 | -22,466,000 | -11,683,000 | -39,251,000 | -25,023,000 | -73,908,000 | -14,081,000 | -26,567,000 | -21,820,000 | -31,069,000 | -78,863,000 | ||||||||||||
amortization and accretion of investments | -267,000 | -53,000 | 171,000 | 173,000 | 187,000 | 113,000 | 65,000 | -2,000 | -83,000 | -110,000 | |||||||||||||||||||||||||||||
other receivables | |||||||||||||||||||||||||||||||||||||||
changes in fair value of derivate liability | -187,000 | ||||||||||||||||||||||||||||||||||||||
proceeds from exercise of stock options | |||||||||||||||||||||||||||||||||||||||
net cash from (used) in investing activities | |||||||||||||||||||||||||||||||||||||||
proceeds from direct stock offering | -33,000 | 107,901,000 | 34,866,000 | 0 | -192,000 | 27,571,000 | |||||||||||||||||||||||||||||||||
proceeds from debt agreement | 0 | 0 | 19,730,000 | ||||||||||||||||||||||||||||||||||||
supplemental disclosures of noncash investing and financing activities: | |||||||||||||||||||||||||||||||||||||||
issuance costs debt included in accounts payable and accrued expenses | 82,000 | ||||||||||||||||||||||||||||||||||||||
net cash (used in)/provided by investing activities | |||||||||||||||||||||||||||||||||||||||
proceeds from issuance of common stock in follow on public offering | |||||||||||||||||||||||||||||||||||||||
depreciation, amortization and accretion | -176,000 | -224,000 | -180,000 | -145,000 | -75,000 | -62,000 | 154,000 | 73,000 | 6,000 | -69,000 | 4,000 | 53,000 | |||||||||||||||||||||||||||
amortization of operating leases | |||||||||||||||||||||||||||||||||||||||
issuance costs included in accounts payable and accrued expenses | 171,000 | 26,000 | 135,000 | ||||||||||||||||||||||||||||||||||||
change in fair value of warrants | |||||||||||||||||||||||||||||||||||||||
proceeds from issuance of common stock in initial public offering | |||||||||||||||||||||||||||||||||||||||
proceeds from issuance of common stock in follow-on public stock offering | |||||||||||||||||||||||||||||||||||||||
property and equipment purchases included in accounts payable and accrued expenses | 1,000 | 73,000 | |||||||||||||||||||||||||||||||||||||
vesting of restricted stock | 0 | 48,000 | 11,000 | 10,000 | |||||||||||||||||||||||||||||||||||
amortization of debt discount and debt issuance costs | |||||||||||||||||||||||||||||||||||||||
change in restricted cash | 49,000 | ||||||||||||||||||||||||||||||||||||||
proceeds from issuance of convertible preferred stock | |||||||||||||||||||||||||||||||||||||||
deferred issuance costs | |||||||||||||||||||||||||||||||||||||||
payments on term loans | |||||||||||||||||||||||||||||||||||||||
net increase in cash and cash equivalents | -1,488,000 | 11,091,000 | 8,000 | ||||||||||||||||||||||||||||||||||||
cash and cash equivalents—beginning of year | |||||||||||||||||||||||||||||||||||||||
cash and cash equivalents—end of year | |||||||||||||||||||||||||||||||||||||||
change in fair value of warrants and derivative | 0 | 0 | 1,720,000 | ||||||||||||||||||||||||||||||||||||
changes in restricted cash | 1,000 | ||||||||||||||||||||||||||||||||||||||
proceeds from issuance of common stock in initial public stock offering | -29,000 | -141,000 | -1,231,000 | 53,549,000 | |||||||||||||||||||||||||||||||||||
proceeds from issuance of common stock in follow on public stock offering | -162,000 | ||||||||||||||||||||||||||||||||||||||
net decrease in cash and cash equivalents | -2,256,000 | ||||||||||||||||||||||||||||||||||||||
cash and cash equivalents—beginning of period | 0 | 0 | 23,844,000 | 0 | 0 | 23,179,000 | |||||||||||||||||||||||||||||||||
cash and cash equivalents—end of period | -2,256,000 | 632,000 | 22,356,000 | -1,688,000 | -8,746,000 | 23,187,000 | |||||||||||||||||||||||||||||||||
accretion of dividends on convertible preferred stock | 2,598,000 | ||||||||||||||||||||||||||||||||||||||
reclassification of common stock warrant liability to additional paid-in capital | 4,551,000 | ||||||||||||||||||||||||||||||||||||||
conversion of preferred stock to common stock upon closing of initial public offering | |||||||||||||||||||||||||||||||||||||||
proceeds from the exercise of stock options | 118,000 | ||||||||||||||||||||||||||||||||||||||
supplemental disclosures of non-cash investing and financing activities: | |||||||||||||||||||||||||||||||||||||||
conversion of preferred stock to common stock upon closing of ipo | 328,942,000 | ||||||||||||||||||||||||||||||||||||||
write-off of deferred costs associated with postponed initial public offering | |||||||||||||||||||||||||||||||||||||||
proceeds from issuance of debt | |||||||||||||||||||||||||||||||||||||||
increase in restricted cash | |||||||||||||||||||||||||||||||||||||||
payments on debt | |||||||||||||||||||||||||||||||||||||||
deferred debt issuance and financing costs | |||||||||||||||||||||||||||||||||||||||
supplement disclosures of cash flow information (note 13). | |||||||||||||||||||||||||||||||||||||||
decrease in restricted cash | 2,000 | ||||||||||||||||||||||||||||||||||||||
principal payments on capital lease obligation | -1,000 | ||||||||||||||||||||||||||||||||||||||
accretion of convertible preferred stock to redemption value | |||||||||||||||||||||||||||||||||||||||
ipo issuance costs included in accounts payable and accrued expenses | 1,400,000 |
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