Sana Biotechnology, Inc(NASDAQ:SANA) 
Sana Biotechnology, Inc., a biotechnology company, focuses on utilizing engineered cells as medicines. The company develops in vivo and ex vivo cell engineering platforms for various therapeutic areas with unmet treatment needs, including oncology, diabetes, central nervous system disorders, cardiov...
Share this website to your friends
• Market Cap:
• Exchange:
• Shs Outstanding:
• Employees:
• Beta:
• Return on Equity (ROE) ttm:
• Return on Assets (ROA) ttm:
• EPS ttm:
• Book value per Share:
• Cash per Share:
• Current ast per Share:
• P/E ttm:
• P/E forward:
• P/E ttm high:
• P/E ttm low:
• P/S ttm:
• P/B ttm:
• P/FCF ttm:
• PEG ratio:
• Cash Ratio ttm:
• Quick Ratio ttm:
• Current Ratio ttm:
• Gross Mgn ttm:
• EBITDA Mgn ttm:
• Operating Mgn ttm:
• Net Income Mgn ttm:
• Trailing Div yield:
• Forward Div yield:
• Payout Ratio ttm:
• Ex-Dividend date:
• Target Price High:
• Target Price Low:
• Target Price Mean:
• Number of Analysts:
• Debt Ratio ttm:
• Debt to Equity ttm:
• Total Net Debt:
At a glance:
Bull Thesis:
Bear Thesis:
Main Competitors:
Moat:
Income Statements:
Quarterly
Annual
| Unit: USD | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
operating expenses: | ||||||||||||||||||||
research and development | 30,106,000 | 29,761,000 | 37,189,000 | 47,036,000 | 53,206,000 | 60,874,000 | 56,448,000 | 63,000,000 | 65,613,000 | 73,044,000 | 67,166,000 | 63,921,000 | 76,735,000 | 72,540,000 | 72,689,000 | 108,505,000 | 53,245,000 | 44,996,000 | 168,930,000 | |
research and development related success payments and contingent consideration | 3,124,000 | 10,262,000 | 1,957,000 | -13,447,000 | -5,497,000 | -27,944,000 | 38,007,000 | 6,835,000 | -82,615,000 | 26,679,000 | 120,000 | -5,454,000 | -6,062,000 | -17,928,000 | -55,438,000 | -9,905,000 | 16,753,000 | -76,025,000 | ||
general and administrative | 10,285,000 | 10,341,000 | 11,484,000 | 17,277,000 | 14,052,000 | 16,442,000 | 16,269,000 | 20,784,000 | 19,183,000 | 16,566,000 | 16,766,000 | 23,321,000 | 15,514,000 | 18,292,000 | 14,434,000 | 12,679,000 | 13,433,000 | 12,477,000 | 11,821,000 | |
impairment of long-lived assets | 44,611,000 | |||||||||||||||||||
total operating expenses | 43,515,000 | 94,975,000 | 50,630,000 | 50,866,000 | 61,761,000 | 49,372,000 | 110,724,000 | 90,619,000 | 2,181,000 | 116,289,000 | 84,052,000 | 81,788,000 | 86,187,000 | 72,904,000 | 31,685,000 | 111,279,000 | 83,431,000 | -18,552,000 | 180,751,000 | |
income from operations | -43,515,000 | -94,975,000 | -50,630,000 | -50,866,000 | -61,761,000 | -49,372,000 | -110,724,000 | -90,619,000 | -2,181,000 | -116,289,000 | -84,052,000 | -81,788,000 | -86,187,000 | -31,685,000 | -111,279,000 | -83,431,000 | -180,751,000 | |||
yoy | -29.54% | 92.37% | -54.27% | -43.87% | 2731.77% | -57.54% | 31.73% | 10.80% | -97.47% | 165.27% | -26.50% | 3.30% | -82.47% | |||||||
qoq | -54.18% | 87.59% | -0.46% | -17.64% | 25.09% | -55.41% | 22.19% | 4054.93% | -98.12% | 38.35% | 2.77% | -5.10% | -71.53% | 33.38% | ||||||
interest income | 1,003,000 | 577,000 | 992,000 | 1,656,000 | 2,579,000 | 3,202,000 | 3,034,000 | 2,726,000 | 2,862,000 | 2,374,000 | 1,976,000 | 1,613,000 | 1,173,000 | 637,000 | 339,000 | 267,000 | 158,000 | 130,000 | 121,000 | |
other income | 360,000 | 598,000 | 249,000 | 141,000 | -742,000 | 215,000 | -224,000 | 303,000 | -268,000 | -106,000 | -198,000 | -102,000 | 281,000 | 10,000 | 1,000 | 13,000 | ||||
net income | -42,152,000 | -93,800,000 | -49,389,000 | -49,069,000 | -59,924,000 | -50,291,000 | -107,475,000 | -88,117,000 | 984,000 | -113,999,000 | -82,123,000 | -80,443,000 | -85,120,000 | -72,465,000 | -31,448,000 | -110,731,000 | -83,263,000 | 18,683,000 | -180,617,000 | |
yoy | -29.66% | 86.51% | -54.05% | -44.31% | -6189.84% | -55.88% | 30.87% | 9.54% | -101.16% | 57.32% | 161.14% | -27.35% | 2.23% | -487.87% | -82.59% | |||||
qoq | -55.06% | 89.92% | 0.65% | -18.11% | 19.15% | -53.21% | 21.97% | -9054.98% | -100.86% | 38.81% | 2.09% | -5.49% | 17.46% | 130.43% | -71.60% | 32.99% | -545.66% | -110.34% | ||
net loss per common share – basic and diluted | -160 | -390 | -210 | -210 | -490 | -590 | -430 | |||||||||||||
weighted-average number of common shares – basic and diluted | 260,494,000 | 238,409,000 | 237,578,000 | 230,891,000 | 234,440,000 | 217,290,000 | 194,541,000 | 192,540,000 | 191,228,000 | |||||||||||
net income per common share – basic | -237.5 | -250 | -252.5 | |||||||||||||||||
weighted-average number of common shares – basic | 235,412,000 | 196,978,000 | ||||||||||||||||||
net income per common share – diluted | -237.5 | -250 | -252.5 | |||||||||||||||||
weighted-average number of common shares – diluted | 235,412,000 | 200,473,000 | ||||||||||||||||||
other expense | -4,121,000 | -84,000 | -47,000 | |||||||||||||||||
net loss per common share - basic and diluted | -252.5 | -450 | -170 | -610 | -460 | |||||||||||||||
weighted-average number of common shares - basic and diluted | 188,344,000 | 189,303,000 | 185,955,000 | 166,433,000 | 181,827,000 | |||||||||||||||
operating expenses | ||||||||||||||||||||
gain from operations | -72,904,000 | 18,552,000 | ||||||||||||||||||
net income per common share - basic | -390 | |||||||||||||||||||
weighted-average number of common shares - basic | 187,626,000 | 179,899 | ||||||||||||||||||
net income per common share - diluted | -390 | |||||||||||||||||||
weighted-average number of common shares - diluted | 187,626,000 | 190,508 | ||||||||||||||||||
net income per share | 0.1 | -1.52 | ||||||||||||||||||
weighted-average shares outstanding, basic and diluted | 119,131 |
Balance Sheets:
Quarterly
Annual
| Unit: USD | 2026-03-31 | 2025-12-31 | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
assets | ||||||||||||||||||||||
current assets: | ||||||||||||||||||||||
cash and cash equivalents | 83,800,000 | 71,870,000 | 103,357,000 | 71,271,000 | 96,131,000 | 127,566,000 | 126,996,000 | 134,958,000 | 177,054,000 | 133,517,000 | 168,448,000 | 173,787,000 | 160,456,000 | 176,765,000 | 163,343,000 | 194,659,000 | 188,517,000 | 253,029,000 | 433,670,000 | 675,140,000 | 750,687,000 | 124,806,000 |
marketable securities | 17,336,000 | 66,512,000 | 49,697,000 | 1,403,000 | 8,570,000 | 24,931,000 | 72,011,000 | 116,685,000 | 134,028,000 | 71,678,000 | 100,122,000 | 152,128,000 | 188,850,000 | 247,198,000 | 322,407,000 | 290,143,000 | 323,861,000 | 297,967,000 | 170,041,000 | 177,696,000 | 209,550,000 | 253,458,000 |
restricted cash | 4,195,000 | 4,195,000 | 4,195,000 | 4,195,000 | 4,195,000 | 3,832,000 | 3,832,000 | 3,832,000 | 3,832,000 | 3,832,000 | 3,832,000 | 6,100,000 | 6,100,000 | 6,100,000 | 6,100,000 | 10,508,000 | 8,819,000 | 8,819,000 | 8,819,000 | 2,143,000 | 2,143,000 | 2,143,000 |
prepaid expenses and other current assets | 6,359,000 | 6,099,000 | 4,510,000 | 5,633,000 | 3,835,000 | 4,479,000 | 7,310,000 | 7,978,000 | 6,349,000 | 4,488,000 | 7,120,000 | 6,606,000 | 14,502,000 | 14,374,000 | 8,400,000 | 9,612,000 | 10,842,000 | 7,105,000 | 9,134,000 | 7,504,000 | 7,237,000 | 6,203,000 |
total current assets | 111,690,000 | 148,676,000 | 161,759,000 | 82,502,000 | 112,731,000 | 160,808,000 | 210,149,000 | 263,453,000 | 321,263,000 | 213,515,000 | 279,522,000 | 338,621,000 | 369,908,000 | 444,437,000 | 500,250,000 | 494,414,000 | 523,220,000 | 558,101,000 | 612,845,000 | 860,340,000 | 967,474,000 | 384,467,000 |
property and equipment | 25,673,000 | 26,906,000 | 29,931,000 | 33,081,000 | 73,687,000 | 77,308,000 | 82,826,000 | 85,909,000 | 81,649,000 | 70,689,000 | 68,369,000 | 62,654,000 | 64,260,000 | 66,917,000 | 67,349,000 | 67,846,000 | 68,693,000 | 65,464,000 | 63,445,000 | 58,670,000 | 50,986,000 | 46,775,000 |
operating lease right-of-use assets | 35,845,000 | 38,313,000 | 40,704,000 | 43,021,000 | 54,837,000 | 57,961,000 | 61,040,000 | 63,154,000 | 71,565,000 | 74,903,000 | 77,235,000 | 94,715,000 | 98,116,000 | 92,486,000 | 95,733,000 | 98,910,000 | 97,145,000 | 96,320,000 | 84,828,000 | 60,330,000 | 61,770,000 | 63,168,000 |
intangible asset | 59,195,000 | 59,195,000 | 59,195,000 | 59,195,000 | 59,195,000 | 59,195,000 | 59,195,000 | 59,195,000 | 59,195,000 | 59,195,000 | 59,195,000 | 59,195,000 | 59,195,000 | 59,195,000 | 59,195,000 | 59,195,000 | 59,195,000 | 59,195,000 | 59,195,000 | 59,195,000 | 59,195,000 | 59,195,000 |
goodwill | 140,627,000 | 140,627,000 | 140,627,000 | 140,627,000 | 140,627,000 | 140,627,000 | 140,627,000 | 140,627,000 | 140,627,000 | 140,627,000 | 140,627,000 | 140,627,000 | 140,627,000 | 140,627,000 | 140,627,000 | 140,627,000 | 140,627,000 | 140,627,000 | 140,627,000 | 140,627,000 | 140,627,000 | 140,627,000 |
other non-current assets | 563,000 | 3,173,000 | 3,216,000 | 3,219,000 | 4,393,000 | 5,121,000 | 5,555,000 | 6,329,000 | 7,078,000 | 6,370,000 | 6,492,000 | 6,927,000 | 4,589,000 | 4,599,000 | 4,717,000 | 4,825,000 | 4,900,000 | 5,000,000 | 591,000 | 598,000 | 644,000 | 190,000 |
total assets | 373,593,000 | 416,890,000 | 435,432,000 | 361,645,000 | 445,470,000 | 501,020,000 | 559,392,000 | 618,667,000 | 681,377,000 | 565,299,000 | 631,440,000 | 707,147,000 | 746,928,000 | 822,720,000 | 898,102,000 | 971,089,000 | 1,047,613,000 | 1,129,407,000 | 1,232,751,000 | 1,259,837,000 | 1,304,466,000 | 730,296,000 |
liabilities and stockholders' equity | ||||||||||||||||||||||
current liabilities: | ||||||||||||||||||||||
accounts payable | 2,123,000 | 1,669,000 | 1,858,000 | 2,270,000 | 989,000 | 5,210,000 | 2,991,000 | 3,817,000 | 6,095,000 | 4,108,000 | 9,928,000 | 3,089,000 | 2,334,000 | 2,857,000 | 3,993,000 | 3,079,000 | 4,765,000 | 2,219,000 | 3,947,000 | 3,704,000 | 4,258,000 | 2,253,000 |
accrued compensation | 7,584,000 | 13,240,000 | 11,296,000 | 9,411,000 | 9,354,000 | 14,449,000 | 18,050,000 | 15,581,000 | 13,965,000 | 23,722,000 | 24,286,000 | 19,669,000 | 17,029,000 | 26,362,000 | 24,500,000 | 17,991,000 | 16,889,000 | 21,131,000 | 20,218,000 | 15,294,000 | 10,811,000 | 16,020,000 |
accrued expenses and other current liabilities | 8,124,000 | 8,679,000 | 7,991,000 | 7,931,000 | 9,810,000 | 13,240,000 | 15,362,000 | 21,293,000 | 19,674,000 | 23,462,000 | 18,940,000 | 18,040,000 | 13,298,000 | 14,547,000 | 14,970,000 | 13,985,000 | 11,321,000 | 10,344,000 | 12,884,000 | 12,830,000 | 11,171,000 | 9,466,000 |
operating lease liabilities | 14,878,000 | 14,938,000 | 14,368,000 | 13,832,000 | 13,003,000 | 12,534,000 | 10,601,000 | 9,998,000 | 13,167,000 | 13,195,000 | 13,490,000 | 12,890,000 | 12,892,000 | 12,393,000 | 11,921,000 | 10,667,000 | 9,635,000 | 9,159,000 | 6,502,000 | 6,004,000 | 3,910,000 | 3,712,000 |
contingent consideration | 53,556,000 | 40,200,000 | 115,141,000 | 117,132,000 | 110,832,000 | 108,968,000 | 111,856,000 | 111,621,000 | 114,990,000 | 58,417,000 | 57,224,000 | 55,345,000 | 59,429,000 | 51,386,000 | 50,900,000 | 51,382,000 | 43,459,000 | 140,457,000 | 133,294,000 | 121,901,000 | ||
total current liabilities | 86,265,000 | 78,726,000 | 35,513,000 | 33,444,000 | 33,156,000 | 45,433,000 | 47,004,000 | 50,689,000 | 52,901,000 | 64,487,000 | 66,644,000 | 112,105,000 | 102,777,000 | 111,504,000 | 114,813,000 | 97,108,000 | 93,510,000 | 99,235,000 | 92,010,000 | 42,832,000 | 35,150,000 | 31,451,000 |
operating lease liabilities, net of current portion | 60,450,000 | 63,924,000 | 67,868,000 | 71,660,000 | 78,311,000 | 81,663,000 | 85,483,000 | 88,559,000 | 92,922,000 | 90,901,000 | 83,374,000 | 100,245,000 | 101,607,000 | 95,860,000 | 99,859,000 | 102,960,000 | 102,518,000 | 101,784,000 | 92,403,000 | 66,149,000 | 66,349,000 | 68,197,000 |
contingent consideration, net of current portion | 80,907,000 | 83,518,000 | 109,606,000 | 103,156,000 | 103,317,000 | 98,615,000 | 95,034,000 | 81,701,000 | 97,999,000 | 102,315,000 | 102,361,000 | 88,522,000 | ||||||||||
success payment liabilities | 16,926,000 | 19,238,000 | 13,726,000 | 8,611,000 | 4,649,000 | 4,556,000 | 15,115,000 | 20,847,000 | 45,422,000 | 12,799,000 | 12,414,000 | 5,000,000 | 5,000,000 | 5,000,000 | 5,000,000 | 76,494,000 | ||||||
other non-current liabilities | 9,805,000 | 10,600,000 | 7,876,000 | 8,242,000 | 9,443,000 | 9,896,000 | 7,456,000 | 7,302,000 | 539,000 | 539,000 | 539,000 | 540,000 | ||||||||||
total liabilities | 254,353,000 | 256,006,000 | 240,124,000 | 239,089,000 | 236,391,000 | 250,516,000 | 266,914,000 | 279,018,000 | 306,235,000 | 277,793,000 | 265,588,000 | 352,118,000 | 318,666,000 | 323,405,000 | 332,083,000 | 331,584,000 | 345,958,000 | 400,905,000 | 402,666,000 | 353,940,000 | 422,483,000 | 298,583,000 |
commitments and contingencies | ||||||||||||||||||||||
stockholders' equity: | ||||||||||||||||||||||
preferred stock, 0.0001 par value... | ||||||||||||||||||||||
common stock, 0.0001 par value... | 27,000 | 27,000 | 26,000 | 23,000 | 23,000 | 22,000 | 22,000 | 22,000 | 22,000 | 20,000 | 20,000 | 20,000 | 19,000 | 19,000 | 19,000 | 19,000 | 19,000 | 18,000 | 18,000 | 18,000 | 18,000 | 2,000 |
additional paid-in capital | 2,015,441,000 | 2,009,845,000 | 1,985,452,000 | 1,870,572,000 | 1,863,295,000 | 1,855,318,000 | 1,848,183,000 | 1,835,503,000 | 1,820,701,000 | 1,625,637,000 | 1,616,008,000 | 1,606,832,000 | 1,567,341,000 | 1,558,459,000 | 1,546,807,000 | 1,535,106,000 | 1,523,616,000 | 1,515,210,000 | 1,504,778,000 | 1,497,232,000 | 1,491,958,000 | 8,216,000 |
accumulated other comprehensive income | -2,000 | 28,000 | 21,000 | 14,000 | 54,000 | -1,366,000 | -82,000 | 13,000 | 56,000 | 30,000 | ||||||||||||
accumulated deficit | -1,896,226,000 | -1,849,016,000 | -1,790,191,000 | -1,748,039,000 | -1,654,239,000 | -1,604,850,000 | -1,555,781,000 | -1,495,857,000 | -1,445,566,000 | -1,338,091,000 | -1,249,974,000 | -1,250,958,000 | -1,136,959,000 | -1,054,836,000 | -974,393,000 | -889,273,000 | -816,808,000 | -785,360,000 | -674,629,000 | -591,366,000 | -610,049,000 | -429,432,000 |
total stockholders' equity | 119,240,000 | 160,884,000 | 195,308,000 | 122,556,000 | 209,079,000 | 250,504,000 | 292,478,000 | 339,649,000 | 375,142,000 | 287,506,000 | 365,852,000 | 355,029,000 | 428,262,000 | 499,315,000 | 566,019,000 | 639,505,000 | 701,655,000 | 728,502,000 | 830,085,000 | 905,897,000 | 881,983,000 | |
total liabilities and stockholders' equity | 373,593,000 | 416,890,000 | 435,432,000 | 361,645,000 | 445,470,000 | 501,020,000 | 559,392,000 | 618,667,000 | 681,377,000 | 565,299,000 | 631,440,000 | 707,147,000 | 746,928,000 | 822,720,000 | 898,102,000 | 971,089,000 | 1,047,613,000 | |||||
accumulated other comprehensive loss | -19,000 | -15,000 | -60,000 | -202,000 | -865,000 | -2,139,000 | -4,327,000 | -6,414,000 | -6,347,000 | -5,172,000 | ||||||||||||
long-term marketable securities | 5,825,000 | 10,051,000 | 25,823,000 | 94,764,000 | 145,014,000 | 195,881,000 | 262,401,000 | 77,934,000 | 21,627,000 | 33,731,000 | ||||||||||||
long-term restricted cash | 4,408,000 | 4,408,000 | 4,408,000 | 4,408,000 | ||||||||||||||||||
success payment liabilities, net of current portion | 36,451,000 | 15,667,000 | 21,007,000 | 35,710,000 | 33,517,000 | 47,615,000 | 97,525,000 | 129,192,000 | 103,963,000 | 187,151,000 | ||||||||||||
liabilities, convertible preferred stock, and stockholders' equity | ||||||||||||||||||||||
convertible preferred stock, 0.0001 par value... | 852,897,000 | |||||||||||||||||||||
stockholders' equity | ||||||||||||||||||||||
total liabilities, convertible preferred stock, and stockholders' equity | 1,129,407,000 | 1,232,751,000 | 1,259,837,000 | 1,304,466,000 | ||||||||||||||||||
liabilities, convertible preferred stock, and stockholders’ deficit | ||||||||||||||||||||||
stockholders’ deficit: | ||||||||||||||||||||||
total stockholders’ deficit | -421,184,000 | |||||||||||||||||||||
total liabilities, convertible preferred stock, and stockholders deficit | 730,296,000 |
Cashflow Statements:
Quarterly
Annual
| Unit: USD | 2026-03-31 | 2025-12-31 | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
operating activities: | |||||||||||||||||||||
net loss | -47,210,000 | -58,825,000 | -42,152,000 | -93,800,000 | -49,389,000 | -59,924,000 | -50,291,000 | -107,475,000 | 984,000 | -113,999,000 | -82,123,000 | -85,120,000 | -72,465,000 | -31,448,000 | -110,731,000 | -83,263,000 | 18,683,000 | -180,617,000 | |||
adjustments to reconcile net loss to net cash from operating activities: | |||||||||||||||||||||
depreciation | 2,391,000 | 3,053,000 | 3,191,000 | 2,857,000 | 3,649,000 | 4,057,000 | 4,499,000 | 4,448,000 | 4,346,000 | 4,195,000 | 4,016,000 | 3,800,000 | 3,614,000 | 3,335,000 | 2,882,000 | 2,606,000 | 2,247,000 | ||||
stock-based compensation expense | 5,662,000 | 6,337,000 | 5,476,000 | 6,629,000 | 7,022,000 | 6,436,000 | 10,770,000 | 11,380,000 | 9,092,000 | 7,931,000 | 9,003,000 | 9,848,000 | 8,751,000 | 10,591,000 | 10,080,000 | 9,911,000 | 7,755,000 | 7,313,000 | 5,950,000 | 4,941,000 | 4,158,000 |
change in the estimated fair value of contingent consideration | 10,745,000 | 8,577,000 | -1,991,000 | 6,300,000 | 1,864,000 | -2,888,000 | 235,000 | -3,369,000 | 5,384,000 | 6,450,000 | -58,578,000 | 5,895,000 | 5,460,000 | 9,249,000 | -8,255,000 | -3,830,000 | -528,000 | 21,762,000 | -8,476,000 | ||
change in the estimated fair value of success payment liabilities | -2,312,000 | 5,512,000 | 5,115,000 | 3,962,000 | 93,000 | -10,559,000 | -5,732,000 | -24,575,000 | 32,623,000 | 385,000 | -24,037,000 | 20,784,000 | -5,340,000 | -14,703,000 | 2,193,000 | -14,098,000 | -54,910,000 | -31,667,000 | 25,229,000 | ||
non-cash expense for operating lease right-of-use assets | 2,468,000 | 2,391,000 | 2,317,000 | 2,230,000 | 2,233,000 | 2,180,000 | 2,114,000 | 2,049,000 | 3,338,000 | 3,234,000 | 3,276,000 | 3,401,000 | 3,354,000 | 3,247,000 | 3,177,000 | 3,076,000 | 2,606,000 | 2,247,000 | 1,759,000 | 1,440,000 | 1,398,000 |
other non-cash items | -2,615,000 | -3,100,000 | -2,082,000 | -2,523,000 | -3,271,000 | -3,225,000 | -2,995,000 | 21,000 | -4,879,000 | -3,350,000 | -3,874,000 | -3,175,000 | -2,913,000 | -2,615,000 | -2,961,000 | -2,289,000 | -1,437,000 | -821,000 | -233,000 | -1,009,000 | -1,013,000 |
changes in operating assets and liabilities: | |||||||||||||||||||||
prepaid expenses and other assets | 1,628,000 | -696,000 | 1,121,000 | -628,000 | 1,368,000 | 3,268,000 | 678,000 | -5,079,000 | -2,380,000 | 2,583,000 | 132,000 | 5,534,000 | -106,000 | -6,557,000 | 1,226,000 | 2,534,000 | -3,191,000 | 2,124,000 | -1,266,000 | -105,000 | -1,614,000 |
operating lease right-of-use assets and liabilities | -1,496,000 | -1,458,000 | -1,458,000 | -972,000 | 891,000 | 1,750,000 | 165,000 | 1,622,000 | 5,804,000 | 8,830,000 | 685,000 | 1,452,000 | -8,000 | -22,000 | 1,473,000 | -261,000 | 372,000 | 60,000 | 1,642,000 | ||
accounts payable | 454,000 | -189,000 | -357,000 | 1,225,000 | -4,224,000 | 2,281,000 | -507,000 | 667,000 | -1,064,000 | -1,336,000 | 2,276,000 | 441,000 | -354,000 | -1,086,000 | 1,481,000 | -1,254,000 | 1,917,000 | -1,663,000 | 1,770,000 | -1,972,000 | 1,599,000 |
accrued expenses and other liabilities | -7,094,000 | 5,757,000 | 1,391,000 | -2,992,000 | -8,893,000 | -3,028,000 | -680,000 | 5,139,000 | -9,821,000 | 167,000 | 2,084,000 | 6,570,000 | -10,339,000 | 2,077,000 | 7,894,000 | 3,398,000 | -2,459,000 | -2,058,000 | 3,520,000 | 7,499,000 | -3,121,000 |
net cash from operating activities | -37,379,000 | -32,641,000 | -29,429,000 | -33,101,000 | -48,657,000 | -47,161,000 | -51,819,000 | -58,541,000 | -65,632,000 | -51,959,000 | -63,550,000 | -58,801,000 | -79,272,000 | -76,067,000 | -64,796,000 | -71,478,000 | -77,709,000 | -110,099,000 | -50,486,000 | -40,556,000 | -49,913,000 |
capital expenditures | -288,000 | -873,000 | -41,000 | 112,000 | -136,000 | -436,000 | -7,211,000 | -18,055,000 | -7,470,000 | -14,508,000 | 5,747,000 | -592,000 | -1,208,000 | -5,777,000 | -5,287,000 | -4,470,000 | -4,108,000 | -5,418,000 | -8,247,000 | -9,899,000 | -3,283,000 |
free cash flows | -37,667,000 | -33,514,000 | -29,470,000 | -32,989,000 | -48,793,000 | -47,597,000 | -59,030,000 | -76,596,000 | -73,102,000 | -66,467,000 | -57,803,000 | -59,393,000 | -80,480,000 | -81,844,000 | -70,083,000 | -75,948,000 | -81,817,000 | -115,517,000 | -58,733,000 | -50,455,000 | -53,196,000 |
investing activities: | |||||||||||||||||||||
purchases of marketable securities | -5,588,000 | -36,084,000 | -49,527,000 | 0 | -1,682,000 | -13,076,000 | -35,970,000 | -62,625,000 | -114,393,000 | -26,127,000 | -60,350,000 | -50,836,000 | -20,431,000 | -15,105,000 | -17,622,000 | -20,286,000 | -25,675,000 | -76,950,000 | -248,886,000 | -120,740,000 | -44,811,000 |
proceeds from maturities of marketable securities | 55,065,000 | 19,800,000 | 1,407,000 | 7,186,000 | 18,168,000 | 60,600,000 | 81,838,000 | 81,499,000 | 53,010,000 | 55,483,000 | 113,931,000 | 95,040,000 | 85,334,000 | 108,135,000 | 53,831,000 | 102,407,000 | 45,753,000 | ||||
purchases of property and equipment | -288,000 | -873,000 | -41,000 | 112,000 | -136,000 | -436,000 | -4,093,000 | -13,056,000 | -15,845,000 | -14,046,000 | -2,233,000 | -1,577,000 | -2,176,000 | -4,602,000 | -4,350,000 | -4,391,000 | -7,533,000 | -5,202,000 | -8,064,000 | -10,156,000 | -6,440,000 |
proceeds from disposal of assets | 248,000 | 661,000 | 136,000 | 382,000 | 253,000 | ||||||||||||||||
net cash from investing activities | 49,437,000 | -16,496,000 | -48,025,000 | 7,680,000 | 16,603,000 | 47,088,000 | 41,775,000 | 5,818,000 | -77,228,000 | 15,310,000 | 51,348,000 | 42,627,000 | 62,727,000 | 88,428,000 | 31,859,000 | 77,730,000 | 12,545,000 | -73,661,000 | -185,904,000 | -35,324,000 | 49,091,000 |
financing activities: | |||||||||||||||||||||
proceeds from employee stock purchase plan and exercise of stock options | 59,000 | 1,059,000 | 157,000 | 333,000 | 1,127,000 | 699,000 | 1,939,000 | 3,438,000 | 4,929,000 | 1,184,000 | 897,000 | 1,579,000 | 652,000 | ||||||||
fees related to common stock financings | -96,000 | ||||||||||||||||||||
principal payments, net for tenant improvement loan | -91,000 | ||||||||||||||||||||
net cash from financing activities | -128,000 | 17,650,000 | 109,540,000 | 561,000 | 982,000 | 643,000 | 2,082,000 | 10,627,000 | 186,397,000 | 1,718,000 | 187,000 | 29,505,000 | 236,000 | 1,061,000 | 1,621,000 | 1,579,000 | 652,000 | 3,119,000 | 1,596,000 | 333,000 | 626,703,000 |
net increase in cash, cash equivalents, and restricted cash | 11,930,000 | -24,860,000 | -31,072,000 | -42,096,000 | 43,537,000 | 13,422,000 | -31,316,000 | 7,831,000 | -64,512,000 | -180,641,000 | -234,794,000 | -75,547,000 | 625,881,000 | ||||||||
cash, cash equivalents, and restricted cash at beginning of period | 76,065,000 | 0 | 0 | 0 | 131,398,000 | 0 | 0 | 0 | 137,349,000 | 0 | 0 | 0 | 187,273,000 | 0 | 0 | 0 | 261,848,000 | 0 | 0 | 0 | 126,949,000 |
cash, cash equivalents, and restricted cash at end of period | 87,995,000 | -31,487,000 | 32,086,000 | -24,860,000 | 100,326,000 | 570,000 | -7,962,000 | -42,096,000 | 180,886,000 | -34,931,000 | -12,015,000 | 13,331,000 | 170,964,000 | 13,422,000 | -31,316,000 | 7,831,000 | 197,336,000 | -180,641,000 | -234,794,000 | -75,547,000 | 752,830,000 |
supplemental cash flow information: | |||||||||||||||||||||
cash received for tenant improvement allowances | 0 | 0 | 0 | 891,000 | 165,000 | 0 | 1,223,000 | 6,121,000 | |||||||||||||
impairment of long-lived assets | 0 | 0 | |||||||||||||||||||
proceeds related to common stock financings | 16,680,000 | 109,470,000 | |||||||||||||||||||
proceeds (principal payments), net for tenant improvement loan | -89,000 | -87,000 | |||||||||||||||||||
net decrease in cash, cash equivalents, and restricted cash | -31,487,000 | 570,000 | -12,015,000 | 13,331,000 | -16,309,000 | ||||||||||||||||
reconciliation of cash, cash equivalents and restricted cash: | |||||||||||||||||||||
cash and cash equivalents | |||||||||||||||||||||
restricted cash | |||||||||||||||||||||
total cash, cash equivalents, and restricted cash | |||||||||||||||||||||
operating lease right-of-use assets obtained in exchange for lease obligations | 0 | 0 | 0 | 8,984,000 | 0 | 0 | 17,642,000 | 3,431,000 | |||||||||||||
purchases of property and equipment included in accounts payable and accrued liabilities | -3,118,000 | -4,999,000 | 8,375,000 | -462,000 | 7,980,000 | 985,000 | 968,000 | -1,175,000 | -937,000 | -79,000 | 3,425,000 | -216,000 | -183,000 | 257,000 | 3,157,000 | ||||||
derecognition of operating lease right-of-use assets for lease termination and modification | |||||||||||||||||||||
derecognition of operating lease right-of-use assets for lease modification | 0 | ||||||||||||||||||||
proceeds (fees) related to common stock financings | -60,000 | ||||||||||||||||||||
principal payments for tenant improvement loan | -85,000 | ||||||||||||||||||||
net income | |||||||||||||||||||||
adjustments to reconcile net income to net cash from operating activities: | |||||||||||||||||||||
depreciation and impairment of long-lived assets | 3,746,000 | ||||||||||||||||||||
proceeds from issuance of common stock from equity financings | 0 | -29,000 | -439,000 | 181,468,000 | |||||||||||||||||
proceeds from tenant improvement loan | -56,000 | 172,000 | |||||||||||||||||||
long-term restricted cash | |||||||||||||||||||||
derecognition of operating lease right-of-use asset for lease termination | 0 | ||||||||||||||||||||
derecognition of operating lease right-of-use asset for lease modification | -899,000 | 0 | |||||||||||||||||||
other investing activities | |||||||||||||||||||||
proceeds from initial public offering, net of issuance costs | |||||||||||||||||||||
proceeds from issuance of common stock | 1,707,000 | 192,000 | 2,491,000 | 236,000 | |||||||||||||||||
proceeds from issuance of common stock under at the market offering | 11,000 | -5,000 | |||||||||||||||||||
remeasurement of operating lease right-of-use asset for lease modification | 0 | 0 | |||||||||||||||||||
cash received for amounts related to tenant improvement allowances | 1,100,000 | 0 | 1,473,000 | 0 | 541,000 | ||||||||||||||||
proceeds from issuance of convertible preferred stock, net of issuance costs | |||||||||||||||||||||
proceeds from at the market offering of common stock, net of issuance costs | -123,000 | ||||||||||||||||||||
reconcilition of cash, cash equivalents and restricted cash: | |||||||||||||||||||||
deferred income tax | |||||||||||||||||||||
non-cash expense in connection with license agreement and asset acquisition | |||||||||||||||||||||
proceeds from sales and maturities of marketable securities | 13,065,000 | 71,046,000 | 95,572,000 | 100,342,000 | |||||||||||||||||
acquisitions, net of cash acquired | |||||||||||||||||||||
issuance of convertible preferred stock for acquisition | |||||||||||||||||||||
proceeds from initial public offering of common stock, net of offering costs | 0 | 0 | 626,405,000 | ||||||||||||||||||
proceeds from exercise of stock options | 1,596,000 | 333,000 | 298,000 | ||||||||||||||||||
supplemental cash flow disclosures: | |||||||||||||||||||||
right-of-use assets obtained in exchange for operating lease liabilities | |||||||||||||||||||||
cash received from lessor for tenant improvement allowance | 1,774,000 | ||||||||||||||||||||
tenant improvement allowance included in operating lease liabilities | -497,000 | -3,580,000 | 8,515,000 | ||||||||||||||||||
change in fair value of contingent consideration | 11,393,000 | ||||||||||||||||||||
change in fair value of success payment liabilities | 115,657,000 | ||||||||||||||||||||
non-cash expense in connection with license agreement | |||||||||||||||||||||
non-cash expense for equity issuance in connection with license agreements | |||||||||||||||||||||
non-cash expense in connection with asset acquisition | |||||||||||||||||||||
issuance of promissory note | |||||||||||||||||||||
payment of contingent consideration | |||||||||||||||||||||
tenant improvement allowance included in contra-lease liability |