7Baggers

Revolution Medicines, Inc
(NASDAQ:RVMD) 

RVMD stock logo

Revolution Medicines, Inc., a clinical-stage precision oncology company, focuses on developing therapies to inhibit frontier targets in RAS-addicted cancers. The company is developing RMC-4630, an inhibitor of SHP2, which is in Phase 1/2 clinical trial for the treatment of solid tumors, such as gyne...

Founded: 2014
Full Time Employees: 117
CEO: Mark A. Goldsmith  
Sector: Healthcare
Industry: Biotechnology

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At a glance:
Bull Thesis:
Bear Thesis:
Main Competitors:
Moat:
Income Statements:
Quarterly
Annual
    Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 
                              
      operating expenses:
                              
      research and development
    343,970,000 294,943,000 262,506,000 224,134,000 205,749,000 188,096,000 151,752,000 134,932,000 118,021,000 148,481,000 107,735,000 97,981,000 68,947,000 66,127,000 69,455,000 61,001,000 56,490,000 53,681,000 46,473,000 45,936,000 40,858,000 37,006,000 34,871,000 32,918,000 27,457,000  
      general and administrative
    101,252,000 66,683,000 52,763,000 40,580,000 35,011,000 28,214,000 23,960,000 21,711,000 22,838,000 32,244,000 15,513,000 14,640,000 13,224,000 10,910,000 10,434,000 10,204,000 9,037,000 8,692,000 7,791,000 7,297,000 6,670,000 5,825,000 5,341,000 5,091,000 5,171,000  
      total operating expenses
    445,222,000 361,626,000 315,269,000 264,714,000 240,760,000 216,310,000 175,712,000 156,643,000 140,859,000 180,725,000 123,248,000 112,621,000 82,171,000 77,037,000 79,889,000 71,205,000 65,527,000 62,373,000 54,264,000 53,233,000 47,528,000 42,831,000 40,212,000 38,009,000 32,628,000  
      income from operations
    -445,222,000 -361,626,000 -315,269,000 -264,714,000 -240,760,000 -216,310,000 -175,712,000 -156,643,000 -140,859,000 -179,983,000 -123,248,000 -108,797,000 -75,157,000 -61,707,000 -76,533,000 -62,089,000 -57,949,000 -52,913,000 -53,163,000 -44,535,000 -37,397,000 -34,080,000 -27,551,000 -27,984,000 -21,082,000  
      yoy
    84.92% 67.18% 79.42% 68.99% 70.92% 20.18% 42.57% 43.98% 87.42% 191.67% 61.04% 75.23% 29.70% 16.62% 43.96% 39.42% 54.96% 55.26% 92.96% 59.14% 77.39%      
      qoq
    23.12% 14.70% 19.10% 9.95% 11.30% 23.10% 12.17% 11.21% -21.74% 46.03% 13.28% 44.76% 21.80% -19.37% 23.26% 7.14% 9.52% -0.47% 19.37% 19.09% 9.73% 23.70% -1.55% 32.74%   
      operating margin %
    -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% NaN% NaN% NaN% -24256.47% NaN% -2845.11% -1071.53% -402.52% -2280.48% -681.10% -764.70% -559.33% -4828.61% -512.01% -369.13% -389.44% -217.61% -279.14% -182.59%  
      non-operating income, net:
                              
      interest income
    19,508,000 21,292,000 22,083,000 22,404,000 24,915,000 21,225,000 20,411,000 21,487,000 23,760,000 18,977,000 10,947,000 10,499,000 7,059,000 5,077,000 2,907,000 867,000 302,000 237,000 223,000 236,000 233,000 252,000 347,000 730,000 909,000  
      interest expense
    -12,197,000 -11,936,000 -11,428,000                  -12,000      
      change in fair value of warrant liability
    -15,788,000                          
      other expense
    -117,000    -10,000    -2,809,000                  
      total non-operating income
    -8,594,000 -3,266,000 10,063,000                        
      income before income taxes
    -453,816,000 -364,892,000 -305,206,000 -247,787,000 -213,416,000 -195,322,000 -156,288,000 -133,233,000 -116,003,000 -161,194,000 -112,301,000 -98,298,000 -68,098,000 -56,630,000 -73,626,000 -61,222,000 -57,647,000 -52,676,000 -52,940,000 -44,299,000 -37,176,000 -33,842,000 -27,221,000 -27,273,000 -20,194,000  
      net income
    -453,816,000 -364,892,000 -305,206,000 -247,787,000 -213,416,000 -194,569,000 -156,288,000 -133,233,000 -116,003,000 -161,537,000 -108,434,000 -98,298,000 -68,098,000 -56,507,000 -73,329,000 -61,222,000 -57,647,000 -52,676,000 -52,940,000 -44,299,000 -37,176,000 -34,204,000 -27,221,000 -27,215,000 -19,519,000  
      yoy
    112.64% 87.54% 95.28% 85.98% 83.97% 20.45% 44.13% 35.54% 70.35% 185.87% 47.87% 60.56% 18.13% 7.27% 38.51% 38.20% 55.07% 54.01% 94.48% 62.77% 90.46%      
      qoq
    24.37% 19.56% 23.17% 16.11% 9.69% 24.49% 17.30% 14.85% -28.19% 48.97% 10.31% 44.35% 20.51% -22.94% 19.78% 6.20% 9.44% -0.50% 19.51% 19.16% 8.69% 25.65% 0.02% 39.43%   
      net income margin %
    -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% NaN% NaN% NaN% -21770.49% NaN% -2570.55% -970.89% -368.60% -2185.01% -671.59% -760.72% -556.83% -4808.36% -509.30% -366.95% -390.86% -215.00% -271.47% -169.05%  
      net income per share
    -2.29 -1.89 -1.61 -1.31 -1.13 -1.13 -0.94 -0.81 -0.7 -1.21 -0.99 -0.92 -0.72 -0.61 -0.87 -0.82 -0.78 -0.72 -0.72 -0.6 -0.53 -0.52 -0.42 -0.46 -0.74  
      weighted-average common shares used to compute net loss per share, basic and diluted
    198,098,047 190,129,154 189,231,562 188,583,288 188,145,904 167,737,672 166,843,984 165,141,936 164,729,200 113,149,869 109,233,084 106,884,185 94,831,979 80,626,525 84,694,860 74,280,590 74,162,363 72,806,079 73,535,686 73,399,714 70,420,076 54,874,119 64,892,868 58,752,494 29,297,698  
      comprehensive loss:
                              
      other comprehensive gain:
                              
      unrealized gain on investments
    -3,851 121 1,814  386 -2,491 5,675 -665 -1,742 1,415 380 -695 1,224              
      comprehensive loss
    -457,667 -364,771 -303,392 -248,192 -213,030 -197,060 -150,613 -133,898 -117,745 -160,122 -108,054 -98,993 -66,874              
      non-operating income:
                              
      change in fair value of warrant liabilities and contingent earn-out shares
     -682,750 -592,000 -4,578,000 2,439,000 1,135,750 -1,269,000 1,907,000 3,905,000                  
      other income
     -10,500    -627,750 282,000 16,000                   
      other income, net:
                              
      interest and other income
       -899,000                       
      total other income
       16,927,000 27,344,000 20,988,000 19,424,000 23,410,000 24,856,000 18,789,000 10,947,000 10,499,000 7,059,000 5,077,000 2,907,000 867,000 302,000 170,000 223,000 236,000 221,000 238,000 330,000 711,000 888,000  
      other comprehensive loss:
                              
      unrealized loss on investments
       -405                       
      revenue:
                              
      collaboration revenue
             742,000  3,824,000 7,014,000 15,330,000 3,356,000 9,116,000 7,578,000 9,460,000 1,101,000 8,698,000 10,131,000      
      total revenue
             742,000  3,824,000 7,014,000 15,330,000 3,356,000 9,116,000 7,578,000 9,460,000 1,101,000 8,698,000 10,131,000 8,751,000 12,661,000 10,025,000 11,546,000  
      yoy
          NaN% NaN% NaN% -95.16% NaN% -58.05% -7.44% 62.05% 204.81% 4.81% -25.20% 8.10% -91.30% -13.24% -12.26%      
      qoq
          NaN% NaN% NaN% NaN% NaN% -45.48% -54.25% 356.79% -63.19% 20.30% -19.89% 759.22% -87.34% -14.14% 15.77% -30.88% 26.29% -13.17%   
      benefit from income taxes
                 123,000 297,000       -362,000  58,000 675,000  
      benefit from income taxes/
             966,750 3,867,000                
      redeemable convertible preferred stock dividends - undeclared and cumulative
                            -2,219,000  
      net loss attributable to common stockholders
                     -52,676,000 -52,940,000 -44,299,000 -37,176,000 -34,204,000 -27,221,000 -27,215,000 -21,738,000  
      collaboration revenue, related party
                         8,751,000 12,661,000 10,025,000 11,546,000  
      interest and other expense
                         -14,250 -17,000 -19,000 -21,000  
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 
                              
        assets
                              
        current assets:
                              
        cash and cash equivalents
      217,442,000 402,438,000 333,554,000 543,064,000 201,262,000 275,713,000 288,432,000 696,148,000 358,399,000 380,330,000 427,222,000 161,412,000 178,941,000 105,781,000 97,667,000 108,497,000 129,154,000 195,600,000 351,595,000 104,268,000 64,871,000 23,976,000 182,669,000 16,659,000 
        marketable securities
      1,714,066,000 1,734,733,000 1,769,121,000 1,746,235,000 1,348,219,000 1,315,002,000 1,415,108,000 1,156,807,000 454,796,000 529,159,000 482,578,000 483,531,000 476,072,000 355,652,000 421,087,000 468,557,000 479,501,000 450,722,000 329,998,000 336,473,000 401,269,000 301,469,000 165,279,000 106,099,000 
        prepaid expenses and other current assets
      45,981,000 39,268,000 31,907,000 38,333,000 29,658,000 34,015,000 25,662,000 25,072,000 10,963,000 10,093,000 8,958,000 10,569,000 15,155,000 15,989,000 10,206,000 6,790,000 7,469,000 8,162,000 8,248,000 6,988,000 7,459,000 7,605,000 5,688,000 2,486,000 
        total current assets
      1,977,489,000 2,176,439,000 2,134,582,000 2,327,632,000 1,579,139,000 1,624,730,000 1,729,202,000 1,879,281,000 824,467,000 922,092,000 922,753,000 660,185,000 675,108,000 483,046,000 534,343,000 589,773,000 623,536,000 661,011,000 697,405,000 454,122,000 482,898,000 340,381,000 362,086,000 133,981,000 
        property and equipment
      32,926,000 33,049,000 27,153,000 24,289,000 24,814,000 25,284,000 23,697,000 22,865,000 20,286,000 19,718,000 18,536,000 18,659,000 18,267,000 15,910,000 13,056,000 11,544,000 10,107,000 10,744,000 10,879,000 8,902,000 7,035,000 7,102,000 6,775,000 7,147,000 
        operating lease right-of-use asset
      134,450,000 114,000,000 115,777,000 117,534,000 74,338,000 75,305,000 76,193,000 77,149,000 53,122,000 53,733,000 54,302,000 55,077,000 56,259,000 57,434,000 58,570,000 59,692,000 25,234,000 25,925,000 26,695,000 27,435,000 28,194,000 28,892,000 8,468,000  
        intangible assets
      55,869,000 56,136,000 56,403,000 56,670,000 56,937,000 57,205,000 57,472,000 57,739,000 58,006,000 58,273,000 58,540,000 58,807,000 59,075,000 59,342,000 59,609,000 59,876,000 60,143,000 60,410,000 60,678,000 60,945,000 61,212,000 61,479,000 61,746,000 62,013,000 
        goodwill
      14,608,000 14,608,000 14,608,000 14,608,000 14,608,000 14,608,000 14,608,000 14,608,000 14,608,000 14,608,000 14,608,000 14,608,000 14,608,000 14,608,000 14,608,000 14,608,000 14,608,000 14,608,000 14,608,000 14,608,000 14,608,000 14,608,000 14,608,000 14,608,000 
        restricted cash
      4,858,000 3,916,000 3,698,000 3,698,000 2,888,000 3,031,000 3,031,000 3,031,000 2,391,000 2,594,000 1,737,000 1,737,000 1,737,000 1,737,000 1,737,000 1,737,000 1,084,000 1,084,000 1,084,000 1,084,000 1,084,000 1,084,000 214,000 214,000 
        long-term deposits
      16,851,000                        
        other noncurrent assets
      14,869,000 31,420,000 13,132,000 13,870,000 10,275,000 8,274,000 4,159,000 7,032,000 11,352,000 2,691,000 2,772,000 2,857,000 856,000 725,000 851,000 758,000 264,000 264,000 302,000 305,000 39,000 411,000 444,000 2,566,000 
        total assets
      2,251,920,000 2,429,568,000 2,365,353,000 2,558,301,000 1,762,999,000 1,808,437,000 1,908,362,000 2,061,705,000 984,232,000 1,073,709,000 1,073,248,000 811,930,000 825,910,000 632,802,000 682,774,000 737,988,000 734,976,000 774,046,000 811,651,000 567,401,000 595,070,000 453,957,000 454,341,000 220,529,000 
        liabilities and stockholdersʼ equity
                              
        current liabilities:
                              
        accounts payable
      74,849,000 56,761,000 47,507,000 54,427,000 24,456,000 29,319,000 32,379,000 61,788,000 29,627,000 29,784,000 19,912,000 21,306,000 24,382,000 14,067,000 14,174,000 14,057,000 10,491,000 10,435,000 9,650,000 12,609,000 6,656,000 10,173,000 7,877,000 11,400,000 
        accrued expenses and other current liabilities
      154,447,000 114,685,000 98,113,000 96,615,000 78,011,000 67,681,000 53,175,000 74,694,000 50,159,000 42,557,000 27,368,000 29,446,000 32,186,000 33,756,000 25,520,000 27,721,000 23,776,000 22,103,000 20,445,000 18,784,000 18,974,000 15,363,000 13,950,000 14,528,000 
        operating lease liability, current
      16,326,000 13,088,000 12,979,000 12,872,000 8,396,000 8,332,000 8,169,000 7,369,000 5,755,000 5,718,000 5,921,000 6,773,000 7,017,000 6,030,000 6,331,000  4,959,000 4,926,000 3,700,000  3,645,000 3,619,000 3,285,000  
        total current liabilities
      245,622,000 184,534,000 158,599,000 163,914,000 110,863,000 105,332,000 93,723,000 143,851,000 85,541,000 78,059,000 54,635,000 61,984,000 73,271,000 63,539,000 57,458,000 60,350,000 51,891,000 45,801,000 43,759,000 47,176,000 42,384,000 43,737,000 41,514,000 43,052,000 
        deferred tax liability
      2,353,000 2,353,000 2,353,000 2,353,000 3,115,000 3,115,000 3,115,000 3,115,000 3,158,000 7,025,000 7,025,000 7,025,000 7,148,000 7,444,000 7,444,000 7,444,000 7,444,000 7,444,000 7,444,000 7,444,000 7,085,000 7,085,000 7,103,000 7,819,000 
        operating lease liability, noncurrent
      142,135,000 119,699,000 121,363,000 122,971,000 78,310,000 79,079,000 79,860,000 80,575,000 57,093,000 57,538,000 57,676,000 57,432,000 58,183,000 58,922,000 59,583,000  26,827,000 27,566,000 28,294,000  29,669,000 30,337,000 7,403,000  
        liability related to the sale of future royalties
      256,509,000 245,081,000                       
        warrant liability
      5,918,000 5,328,000 750,000 3,189,000    6,512,000                 
        other noncurrent liabilities
      2,479,000 7,204,000 4,138,000 670,000 1,644,000 656,000 3,040,000 1,458,000 982,000 252,000 1,694,000 301,000 471,000 219,000 1,634,000 634,000 932,000 608,000 1,439,000 632,000 1,089,000 691,000 589,000 655,000 
        total liabilities
      655,016,000 564,199,000 287,203,000 293,097,000 196,695,000 189,589,000 182,895,000 235,511,000 146,774,000 142,874,000 121,030,000 126,742,000 144,491,000 133,961,000 131,781,000 135,420,000 96,772,000 89,040,000 89,071,000 92,725,000 90,000,000 93,459,000 69,025,000 67,994,000 
        commitments and contingencies
                              
        stockholdersʼ equity:
                              
        preferred stock, 0.0001 par value...
                              
        common stock, 0.0001 par value...
      18,000 18,000 18,000 18,000 16,000 16,000 16,000 16,000 11,000 11,000 11,000 9,000 9,000 8,000 8,000 8,000 8,000 8,000 8,000 7,000 7,000 6,000 6,000  
        additional paid-in capital
      4,097,980,000 4,063,053,000 4,027,642,000 4,001,666,000 3,105,708,000 3,007,639,000 2,980,360,000 2,963,342,000 1,814,489,000 1,799,812,000 1,722,202,000 1,388,300,000 1,328,663,000 1,072,103,000 1,062,552,000 1,055,572,000 1,038,196,000 1,032,009,000 1,025,230,000 740,098,000 736,193,000 564,321,000 562,179,000 4,738,000 
        accumulated other comprehensive income
      3,116,000 1,302,000 1,707,000 1,321,000 3,812,000 -1,863,000 -1,198,000 544,000     -2,419,000 -1,765,000 -1,284,000 -376,000 -40,000 9,000 63,000 116,000 211,000 291,000 36,000 74,000 
        accumulated deficit
      -2,504,210,000 -2,199,004,000 -1,951,217,000 -1,737,801,000 -1,543,232,000 -1,386,944,000 -1,253,711,000 -1,137,708,000 -976,171,000 -867,737,000 -769,439,000 -701,341,000 -644,834,000 -571,505,000 -510,283,000 -452,636,000 -399,960,000 -347,020,000 -302,721,000 -265,545,000 -231,341,000 -204,120,000  -157,386,000 
        total stockholdersʼ equity
      1,596,904,000 1,865,369,000 2,078,150,000 2,265,204,000 1,566,304,000 1,618,848,000                   
        total liabilities and stockholdersʼ equity
      2,251,920,000 2,429,568,000 2,365,353,000 2,558,301,000 1,762,999,000 1,808,437,000                   
        accounts receivable
             1,254,000 309,000 2,510,000 3,995,000 4,673,000 4,940,000 5,624,000 5,383,000  7,412,000 6,527,000 7,564,000      
        warrant liabilities
          2,763,000 1,407,000 3,157,000                  
        liabilities and stockholders' equity
                              
        stockholders' equity:
                              
        total stockholders' equity
            1,725,467,000 1,826,194,000   952,218,000 685,188,000 681,419,000 498,841,000 550,993,000  638,204,000 685,006,000 722,580,000 474,676,000 505,070,000 360,498,000 385,316,000  
        total liabilities and stockholders' equity
            1,908,362,000 2,061,705,000   1,073,248,000 811,930,000 825,910,000 632,802,000 682,774,000          
        deferred revenue, current
                1,434,000 4,459,000 9,686,000 9,686,000 11,433,000 12,358,000 12,665,000 8,337,000 9,964,000      
        liabilities and stockholders’ equity
                              
        stockholders’ equity:
                              
        accumulated other comprehensive loss
              -871,000 -1,251,000 -556,000 -1,780,000             
        total stockholders’ equity
              837,458,000 930,835,000      602,568,000         
        total liabilities and stockholders’ equity
              984,232,000 1,073,709,000               
        deferred revenue, noncurrent
                  5,418,000 3,837,000 5,662,000 6,573,000 9,678,000 7,621,000 8,135,000      
        account receivable
                     5,929,000         
        liabilities, redeemable convertible preferred stock and stockholders' equity
                              
        operating lease liability
                     6,214,000    3,672,000     
        total liabilities, redeemable convertible preferred stock and stockholders’ equity
                     737,988,000         
        total liabilities, redeemable convertible preferred stock and stockholders' equity
                      734,976,000 774,046,000 811,651,000 567,401,000 595,070,000 453,957,000 454,341,000  
        stockholders' equity
                              
        receivable from related party
                         6,393,000 9,299,000 7,331,000 8,450,000 8,737,000 
        deferred revenue, related party, current
                         12,111,000 13,109,000 14,582,000 16,402,000 17,124,000 
        deferred rent, noncurrent
                             1,741,000 
        deferred revenue, related party, noncurrent
                         8,481,000 9,773,000 11,609,000 12,416,000 14,727,000 
        redeemable convertible preferred stock, 0.0001 par value...
                             305,109,000 
        accumulated
                            -176,905,000  
        assets held for sale
                              
        liabilities, redeemable convertible preferred stock and stockholders' deficit
                              
        stockholders' (deficit) equity:
                              
        total stockholders' deficit
                             -152,574,000 
        total liabilities, redeemable convertible preferred stock and stockholders' deficit
                             220,529,000 
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 
                                 
          cash flows from operating activities
                                 
          net loss
        -453,816,000 -364,892,000 -305,206,000 -247,787,000 -213,416,000 -194,569,000 -156,288,000 -133,233,000 -116,003,000 -161,537,000 -108,434,000 -98,298,000 -68,098,000 -56,507,000 -73,329,000 -61,222,000 -57,647,000 -52,676,000 -52,940,000 -44,299,000 -37,176,000 -34,204,000 -27,221,000 -27,215,000 -19,519,000 
          adjustments to reconcile net loss to net cash from operating activities:
                                 
          amortization of intangible assets
         69,000 267,000 267,000 267,000 267,000 268,000 267,000 267,000 267,000 267,000 267,000 267,000 268,000 267,000 267,000 267,000 267,000 267,000 268,000 267,000 267,000 267,000 267,000 267,000 
          stock-based compensation expense
        87,299,000 33,696,000 30,779,000 28,830,000 25,084,000 22,439,000 20,775,000 19,775,000 16,208,000 25,427,000 13,666,000 12,980,000 9,699,000 8,316,000 8,138,000 8,098,000 6,644,000 6,197,000 5,827,000 5,313,000 3,387,000 2,632,000 2,670,000 2,017,000 1,567,000 
          depreciation and amortization
        2,346,000 2,267,000 2,063,000 1,758,000 1,692,000       1,223,000 1,205,000 1,149,000 991,000 931,000 901,000 816,000 793,000 803,000 671,000 674,000 665,000 640,000 632,000 
          change in fair value of warrant liability
        15,788,000                         
          non-cash interest expense on liabilities related to sale of future royalties
        12,197,000                         
          net amortization of premium or discount on marketable securities
        -3,223,000 -4,554,000 -5,717,000 -7,743,000 -9,817,000 -8,826,000 -9,593,000 -10,902,000 -15,244,000 -8,633,000 -5,144,000 -4,851,000 -3,577,000             
          amortization of operating lease right-of-use asset
        2,189,000 2,366,000 2,008,000 1,777,000 1,757,000 1,385,000 967,000 888,000 956,000 1,244,000 611,000 283,000 1,061,000 1,182,000 1,175,000 1,136,000 1,122,000 979,000 691,000 770,000 740,000 759,000 698,000 764,000 645,000 
          changes in operating assets and liabilities:
                                 
          prepaid expenses and other current assets
        -10,471,000 -3,377,000 -5,355,000 -7,361,000 6,426,000 -5,112,000 4,357,000 -8,353,000 -590,000 -2,252,000 -870,000 -1,135,000 1,611,000 4,586,000 834,000 -5,783,000 -3,416,000 638,000 694,000 123,000 -1,257,000 158,000 459,000 661,000 -3,202,000 
          accounts payable
        16,857,000 -10,501,000 19,545,000 8,761,000 -8,270,000 29,363,000 -2,788,000 -4,080,000 -28,960,000 24,305,000 580,000 8,634,000 -1,050,000 -1,507,000 10,239,000 -952,000 -492,000 2,573,000 189,000 1,608,000 -2,131,000 4,616,000 -3,370,000 2,143,000 -3,084,000 
          accrued expenses and other current liabilities
        -16,739,000 54,604,000 45,294,000 10,820,000 1,549,000 18,298,000 10,281,000 14,665,000 -21,259,000 -6,291,000 7,577,000 15,134,000 -1,752,000 -2,966,000 -1,295,000 7,877,000 -2,114,000 3,743,000 1,734,000 2,043,000 1,200,000 -191,000 3,760,000 2,249,000 -963,000 
          operating lease liability
        -2,073,000 241,000 1,858,000 -1,555,000 -1,501,000 993,000 -705,000 -618,000 85,000 -175,000 -408,000 -55,000 -894,000 -995,000 248,000 -962,000 -719,000 -590,000 -706,000 498,000 -670,000 -650,000 -642,000 -498,000 -775,000 
          long-term deposits
        -10,561,000 -7,297,000                        
          other prepaid and noncurrent assets
        378,000                         
          other noncurrent liabilities
        5,664,000 -1,270,000 -3,966,000 2,305,000 3,468,000 -768,000 1,075,000 -2,227,000 2,132,000 -524,000 730,000 -1,442,000 1,393,000 -170,000 340,000 -1,391,000 1,031,000 -271,000 366,000 -797,000 853,000 -390,000 439,000 146,000 -19,000 
          net cash from operating activities
        -354,165,000 -274,238,000 -207,311,000 -221,757,000 -194,435,000 -138,290,000 -130,419,000 -128,167,000 -160,560,000 -120,563,000 -100,497,000 -67,121,000 -62,391,000 -61,788,000 -51,737,000 -55,716,000 -55,160,000 -39,265,000 -36,588,000 -34,081,000 -37,246,000 -25,034,000 -27,021,000 -19,991,000 -28,018,000 
          capital expenditures
        -752,000 -1,471,000 -4,834,000 -7,328,000 -481,000 -262,000 -5,666,000 -1,526,000 -1,278,000 -1,035,000 -3,236,000 167,000 -1,014,000 -4,211,000 -3,701,000 -1,268,000 -217,000 -98,000 -648,000 -1,956,000 -2,697,000 203,000 -776,000 19,000 -566,000 
          free cash flows
        -354,917,000 -275,709,000 -212,145,000 -229,085,000 -194,916,000 -138,552,000 -136,085,000 -129,693,000 -161,838,000 -121,598,000 -103,733,000 -66,954,000 -63,405,000 -65,999,000 -55,438,000 -56,984,000 -55,377,000 -39,363,000 -37,236,000 -36,037,000 -39,943,000 -24,831,000 -27,797,000 -19,972,000 -28,584,000 
          cash flows from investing activities
                                 
          purchases of marketable securities
        -209,733,000 -296,485,000 -459,038,000 -529,291,000 -510,036,000 -695,210,000 -364,877,000 -374,855,000 -701,681,000 -519,605,000 -170,039,000 -176,175,000 -193,097,000 -160,335,000 -212,964,000 -127,652,000 -111,818,000 -110,814,000 -168,248,000 -278,235,000 -114,038,000 -44,876,000 -194,052,000 -205,167,000 -100,038,000 
          maturities of marketable securities
        383,886,000 373,292,000 487,236,000 564,633,000 497,353,000 303,529,000 346,928,000 485,198,000 456,882,000 141,520,000 249,926,000 133,750,000 198,851,000 156,107,000 93,051,000 192,579,000 157,732,000 120,530,000 129,533,000 156,765,000 119,926,000 108,991,000 93,772,000 66,140,000 40,925,000 
          purchases of property and equipment
        -1,538,000 -1,925,000 -3,349,000 -7,450,000 -3,266,000 -1,222,000 -3,520,000 -2,399,000 -3,167,000 -2,317,000 -2,535,000 -1,119,000 -1,758,000 -2,876,000 -3,525,000 -2,526,000 -1,889,000 -1,183,000 -454,000 -1,312,000 -3,579,000 -1,169,000 -687,000 -474,000 -603,000 
          net cash from investing activities
        172,615,000 74,882,000 24,849,000 34,276,000 -15,949,000 -392,903,000 -21,469,000 107,944,000 -247,966,000 -380,402,000 77,352,000 -43,544,000 3,996,000 -7,104,000 -123,438,000 62,401,000 44,025,000 8,533,000 -30,177,000 -122,782,000 2,309,000 62,946,000 -100,967,000 -136,496,000 -59,716,000 
          cash flows from financing activities
                                 
          proceeds from issuance of common stock upon at-the-market offering, net of issuance costs
        226,730,000                        
          proceeds from issuance of common stock under equity incentive plans
        12,209,000  4,145,000 1,937,000 891,000 4,179,000 3,001,000 4,340,000 810,000 1,338,000 1,011,000 468,000 499,000 777,000 209,000 190,000 305,000 356,000 319,000 257,000 555,000 687,000 1,077,000 86,000 27,000 
          exercise of warrants
        57,000 3,000 1,000                     
          deferred offering costs
        -252,000  45,000 2,000 -18,000                     
          net cash from financing activities
        238,744,000 365,659,000 -1,592,000 256,583,000 874,000 873,805,000 77,294,000 7,504,000 810,000 839,354,000 1,011,000 64,630,000 324,205,000 51,363,000 248,335,000 1,429,000 305,000 10,728,000 319,000 868,000 282,264,000 1,485,000 168,883,000 -1,336,000 253,744,000 
          net increase in cash, cash equivalents and restricted cash
        57,194,000     342,612,000 -74,594,000 -12,719,000 -407,716,000 338,389,000 -22,134,000 -46,035,000 265,810,000 -17,529,000 73,160,000 8,114,000 -10,830,000 -20,004,000 -66,446,000 -155,995,000 247,327,000 39,397,000 40,895,000 -157,823,000 166,010,000 
          cash, cash equivalents and restricted cash - beginning of period
        388,603,000  546,762,000  699,179,000  163,149,000  110,234,000  105,352,000     
          cash, cash equivalents and restricted cash - end of period
        445,797,000 166,303,000 -184,054,000 69,102,000 337,252,000 342,612,000 -74,594,000 -12,719,000 291,463,000 338,389,000 -22,134,000 -46,035,000 428,959,000 -17,529,000 73,160,000 8,114,000 99,404,000  -66,446,000 -155,995,000 352,679,000  40,895,000   
          reconciliation of cash, cash equivalents and restricted cash to consolidated balance sheets
                                 
          cash and cash equivalents
        440,939,000 166,303,000 -184,996,000 68,884,000 333,554,000 341,802,000 -74,451,000 -12,719,000 288,432,000 337,749,000 -21,931,000 -46,892,000 427,222,000 -17,529,000 73,160,000 8,114,000 97,667,000 -20,657,000 -66,446,000 -155,995,000 351,595,000 39,397,000 40,895,000 -158,693,000 182,669,000 
          restricted cash
        4,858,000 942,000 218,000 3,698,000 810,000 -143,000 3,031,000 640,000 -203,000 857,000 1,737,000 1,737,000 653,000 1,084,000 870,000 214,000 
          supplemental disclosure of non-cash investing and financing activities
                                 
          purchases of property and equipment in accounts payable and accrued expenses and other current liabilities
        786,000 454,000 -1,485,000 122,000 2,785,000 960,000 -2,146,000 873,000 1,889,000 1,282,000 -701,000 1,286,000 744,000 -1,335,000 -176,000 1,258,000 1,672,000 1,085,000 -194,000 -644,000 882,000 1,372,000 -89,000 493,000 37,000 
          loss on disposal of fixed assets
            -200,000 202,000 43,000 73,000 51,000 1,000   19,000         
          change in fair value of warrant liability and contingent earn-out shares
                                 
          accounts receivable
             1,254,000 -945,000 2,201,000 1,485,000 678,000 267,000 684,000 -241,000 546,000  -885,000 1,037,000 -1,171,000     
          deferred revenue
                 -1,434,000 -3,025,000 -10,645,000 1,581,000 -3,572,000 -1,836,000 -3,412,000 6,385,000 -2,141,000 -2,493,000     
          deferred tax liability
                 -43,000    -123,000        359,000 -18,000 -716,000 
          other noncurrent assets
         -154,000 3,790,000 -17,273,000 765,000 8,000 -1,881,000 -4,127,000 125,000 7,081,000 -8,673,000 88,000 90,000 -2,051,000 -153,000 71,000 -114,000     -266,000 131,000   
          sales of marketable securities
                            
          cash, cash equivalents and restricted cash acquired in connection with eqrx acquisition, net of transaction costs
                                 
          proceeds from the sale of future royalties, net of issuance costs
                                 
          proceeds from issuance of common stock, net of issuance costs
                        -564,000 281,709,000 -34,000    
          proceeds from issuance of pre-funded warrants, net of transaction costs
                                 
          proceeds from issuance of common stock from at-the-market offering, net of transaction costs
                                 
          proceeds from issuance of common stock pursuant to stock option exercises
                                 
          proceeds from issuance of common stock related to employee stock purchase plan
         3,392,000   1,865,000   1,208,000   625,000          
          tax payment for common stock withheld in satisfaction of withholding tax requirements
                                 
          payments of deferred offering costs
                                 
          cash, cash equivalents and restricted cash - beginning of year
                               16,873,000 
          cash, cash equivalents and restricted cash - end of year
                               -157,823,000 182,883,000 
          issuance of common stock for eqrx acquisition
                                 
          fair value of net assets acquired in connection with eqrx acquisition
                                 
          right-of-use assets obtained in exchange for operating lease liabilities
                   286,000           
          change in fair value of warrant liabilities and contingent earn-out shares
          592,000 4,578,000 -2,439,000  1,269,000 -1,907,000 -3,905,000                 
          non-cash interest expense on liability related to sale of future royalties
          11,428,000                       
          impairment of assets
              2,761,000                 
          proceeds from the sale of future royalties
          -5,785,000                       
          net decrease in cash, cash equivalents and restricted cash
          -184,054,000 69,102,000 -209,510,000                     
          unpaid issuance costs on the liability related to the sale of future royalties
                                 
          depreciation
              1,642,000 1,642,000 1,540,000 1,347,000                
          proceeds from issuance of common stock upon follow-on offering, net of issuance costs
                  323,706,000             
          unpaid/deferred offering costs
                15,000 -1,000 -11,000 7,000 7,000             
          eqrx acquisition transaction costs incurred but not paid
                                 
          vesting of early exercised options and restricted stock
                     88,000 24,000 31,000 27,000 42,000 34,000 46,000 67,000 41,000 44,000 47,000 
          advance payments for property and equipment
                                 
          net amortization of premium (discount) on marketable securities
                           693,000 534,000 586,000 400,000 87,000 -105,000 
          proceeds from issuance of common stock from at-the-market offering
                                 
          unpaid deferred offering costs
                       -72,000 89,000      -207,000   
          loss on disposal of fixed asset
                                 
          net amortization of premium on marketable securities
                       27,000 648,000         
          loss on disposal of property and equipment
                                 
          loss on disposal of held for sale assets
                                 
          account receivable
                                 
          deferred rent
                                 
          proceeds from sales of property and equipment
                                 
          proceeds from sale of held for sale assets
                                 
          proceeds from issuance of redeemable convertible preferred stock, net of issuance costs
                                 
          proceeds from issuance of common stock under employee stock purchase plan
                                 
          repurchases of early exercised stock options
                                 
          cash, cash equivalents and restricted cash – beginning of year
                                 
          cash, cash equivalents and restricted cash – end of year
                                 
          repurchases of early exercised stock
                                 
          unpaid offering costs
                            564,000    1,417,000 
          change in fair value of redeemable convertible preferred stock liability
                                 
          receivable from related party
                             2,906,000 -1,968,000 1,119,000 287,000 
          deferred revenue, related party
                             -2,290,000 -3,309,000 -2,627,000 -3,033,000 
          cash acquired in warp drive acquisition
                                 
          redeemable convertible preferred stock issued in warp drive acquisition
                                 
          extinguishment of redeemable convertible preferred stock liability
                                 
          unpaid consideration for warp drive acquisition included within accrued expenses and other current liabilities
                                 
          conversion of convertible note payable into series b redeemable convertible preferred stock
                                 
          loss on disposal of held-for-sale assets
                                 
          proceeds from sale of property and equipment
                                 
          proceeds from sale of held-for-sale assets
                                 
          gain on disposal of property and equipment
                                 
          proceeds from issuance of common stock in initial public offering, net of issuance costs
                               -1,417,000 253,717,000 
          unpaid series c redeemable convertible preferred stock issuance costs
                                 
          purchases of property and equipment in accounts payable