7Baggers

Rigel Pharmaceuticals, Inc
(NASDAQ:RIGL) 

RIGL stock logo

Rigel Pharmaceuticals, Inc., a biotechnology company, discovers and develops small molecule drugs to treat hematologic disorders, cancer, and rare immune diseases. The company offers Tavalisse, an oral spleen tyrosine kinase inhibitor for the treatment of adult patients with chronic immune thrombocy...

Founded: 1996
Full Time Employees: 163
Sector: Healthcare
Industry: Biotechnology
Pharmaceuticals
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Quarterly
Annual
    Unit: USD2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-09-30 2017-06-30 2017-03-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-09-30 2014-06-30 2014-03-31 2013-09-30 2013-06-30 2012-03-31 2009-06-30 2008-09-30 2008-06-30 2008-03-31 2007-12-31 2007-09-30 2007-06-30 2007-03-31 2006-12-31 2006-09-30 2006-06-30 2006-03-31 2005-12-31 2005-09-30 2005-06-30 2005-03-31 2004-12-31 2004-09-30 2004-06-30 2004-03-31 2003-12-31 2003-09-30 2003-06-30 2003-03-31 2002-12-31 2002-09-30 2002-06-30 2002-03-31 2001-09-30 2001-06-30 2001-03-31 
                                                                                   
      revenues:
    		                                                                               
      product sales
    		65,418,000 64,067,000 58,948,000 43,550,000 46,522,000 38,927,000 33,450,000 26,003,000 29,539,000 27,129,000 23,881,000 23,745,000 22,783,000 19,188,000 18,550,000 16,197,000 17,569,000 16,012,000 17,053,000 12,376,000 17,753,000 16,289,000 14,974,000 12,680,000 13,829,000 11,716,000 10,173,000 8,054,000 7,295,000 4,865,000 1,787,000                                                 
      contract revenues from collaborations
    		4,119,000 5,395,000 42,737,000 9,783,000 11,074,000 16,380,000 3,391,000 3,531,000 6,153,000 1,005,000 2,005,000 2,325,000 26,495,000 722,000 11,269,000 538,000 1,840,000 4,531,000 3,713,000 65,642,000 697,000 2,100,000 1,047,000 43,081,000 1,571,000 9,141,000 234,000 4,570,000     900,000  3,584,000 3,760,000 8,594,000 5,029,000 8,537,000 12,996,000 5,184,000 2,178,000     1,400,000 750,000         3,128,000 6,127,000 14,321,000 9,897,000 6,020,000 3,282,000 4,606,000 2,618,000 908,250 659,000 1,487,000 1,487,000 2,237,250 2,103,000 2,349,000 4,497,000 3,022,000 3,653,000 4,337,000 4,098,000 4,206,000   
      total revenues
    		69,802,000 69,462,000 101,685,000 53,333,000 57,596,000 55,307,000 36,841,000 29,534,000 35,792,000 28,134,000 26,886,000 26,070,000 51,278,000 22,410,000 29,819,000 16,735,000 20,409,000 21,543,000 26,266,000 81,018,000 18,450,000 18,389,000 16,021,000 55,761,000 15,400,000 20,857,000 10,407,000 12,624,000 37,857,000 4,865,000 1,787,000                                                 
      yoy
    		21.19% 25.59% 176.01% 80.58% 60.92% 96.58% 37.03% 13.29% -30.20% 25.54% -9.84% 55.78% 151.25% 4.02% 13.53% -79.34% 10.62% 17.15% 63.95% 45.30% 19.81% -11.83% 53.94% 341.71% -59.32% 328.72% 482.37%                                                     
      qoq
    		0.49% -31.69% 90.66% -7.40% 4.14% 50.12% 24.74% -17.48% 27.22% 4.64% 3.13% -49.16% 128.82% -24.85% 78.18% -18.00% -5.26% -17.98% -67.58% 339.12% 0.33% 14.78% -71.27% 262.08% -26.16% 100.41% -17.56% -66.65% 678.15% 172.24%                                                  
      costs and expenses:
    		                                                                               
      cost of product sales
    		5,955,000 4,753,000 4,504,000 4,409,000 5,789,000 8,026,000 2,807,000 2,025,000 3,790,000 1,268,000 1,075,000 977,000 342,000 250,000 1,036,000 121,000 487,000 151,000 129,000 316,000 321,000 140,000 279,000 155,000 178,000 310,000 311,000 107,000 188,000 69,000 30,000                                                 
      research and development
    		10,685,000 7,353,000 6,821,000 8,436,000 5,632,000 6,182,000 5,540,000 6,026,000 3,186,000 6,475,000 4,772,000 10,089,000 15,365,000 14,666,000 14,767,000 15,474,000 13,304,000 18,300,000 16,807,000 16,826,000 15,138,000 14,600,000 14,214,000 16,149,000 14,247,000 14,463,000 13,226,000 10,949,000 13,767,000 11,097,000 10,797,000 11,242,000 10,808,000 11,524,000 12,376,000 16,171,000 17,468,000 18,173,000 16,563,000 15,501,000 15,059,000 15,702,000 16,151,000 20,063,000 16,869,000 17,574,000 19,393,000 17,904,000 24,948,000 31,232,000 28,416,000 21,620,000 12,101,000 15,372,000 17,189,000 15,843,000 15,002,000 14,050,000 13,205,000 14,711,000 13,382,000 13,676,000 13,807,000 11,173,000 9,057,000 13,266,000 11,268,000 11,694,000 7,924,250 10,989,000 10,698,000 10,010,000 8,445,250 11,624,000 12,066,000 10,091,000 8,631,000   
      selling, general and administrative
    		29,992,000 28,936,000 29,257,000 27,715,000 29,520,000 27,043,000 28,047,000 28,449,000 26,850,000 24,856,000 26,306,000 27,729,000 32,172,000 25,897,000 26,981,000 27,401,000 24,515,000 22,877,000 22,378,000 22,121,000 21,818,000 17,430,000 18,920,000 18,430,000 18,312,000 18,121,000 18,209,000 19,946,000 21,370,000 18,069,000 17,071,000                                                 
      total costs and expenses
    		46,632,000 41,042,000 40,582,000 40,560,000 40,941,000 41,251,000 36,394,000 36,500,000 33,826,000 32,599,000 32,153,000 38,795,000 49,199,000 40,813,000 42,784,000 42,996,000 41,827,000 41,328,000 39,314,000 39,263,000 37,277,000 32,170,000 33,413,000 34,734,000 32,737,000 32,894,000 31,746,000 31,002,000 35,325,000 29,235,000 27,898,000 24,734,000 18,755,000 19,344,000 19,786,000 26,499,000 22,242,000 22,596,000 21,284,000 19,777,000 19,158,000 20,419,000 21,040,000 25,456,000 22,385,000 23,930,000 24,285,000 24,060,000                                
      income from operations
    		23,170,000 28,420,000 61,103,000 12,773,000 16,655,000 14,056,000 447,000 -6,966,000 1,966,000 -4,465,000 -5,267,000 -12,725,000 2,079,000 -18,403,000 -12,965,000 -26,261,000 -21,418,000 -19,785,000 -13,048,000 41,755,000 -18,827,000 -13,781,000 -17,392,000 21,027,000 -17,337,000 -12,037,000 -21,339,000 -18,378,000 2,532,000 -24,370,000 -26,111,000 -24,734,000 -17,855,000 -19,344,000 -16,202,000 -22,739,000 -13,648,000 -17,567,000 -12,747,000 -6,781,000                                        
      yoy
    		39.12% 102.19% 13569.57% -283.36% 747.15% -414.80% -108.49% -45.26% -5.44% -75.74% -59.38% -51.54% -109.71% -6.99% -0.64% -162.89% 13.76% 43.57% -24.98% 98.58% 8.59% 14.49% -18.50% -214.41% -784.72% -50.61% -18.28% -25.70% -114.18% 25.98% 61.16% 8.77% 30.83% 10.12% 27.10% 235.33%                                            
      qoq
    		-18.47% -53.49% 378.38% -23.31% 18.49% 3044.52% -106.42% -454.32% -144.03% -15.23% -58.61% -712.07% -111.30% 41.94% -50.63% 22.61% 8.25% 51.63% -131.25% -321.78% 36.62% -20.76% -182.71% -221.28% 44.03% -43.59% 16.11% -825.83% -110.39% -6.67% 5.57% 38.53% -7.70% 19.39% -28.75% 66.61% -22.31% 37.81% 87.98%                                         
      operating margin %
    		33.19% 40.91% 60.09% 23.95% 28.92% 25.41% 1.21% -23.59% 5.49% -15.87% -19.59% -48.81% 4.05% -82.12% -43.48% -156.92% -104.94% -91.84% -49.68% 51.54% -102.04% -74.94% -108.56% 37.71% -112.58% -57.71% -205.04% -145.58% 6.69% -500.92% -1461.16% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% 
      interest income
    		1,243,000 1,094,000 753,000 591,000 522,000 425,000 552,000 593,000 678,000 672,000 529,000 393,000 429,000 192,000 42,000 21,000 16,000 14,000 16,000 1,000 19,000 36,000 169,000 358,000 464,000 555,000 733,000 780,000 696,000 604,000 554,000 349,000 195,000 197,000 156,000 110,000 115,000 103,000 60,000 54,000 62,000 48,000 98,000 65,000 82,000 106,000 117,000 136,000 159,000 1,034,000 1,289,000 1,530,000 1,043,000 1,538,000 1,419,000 1,215,000 1,413,000 1,447,000 1,426,000 1,413,000 1,275,000 935,000 402,000 330,000 171,000 255,000 266,000 163,000 60,750 125,000 46,000 72,000 183,000 172,000 266,000 294,000 437,000   
      interest expense
    		-1,699,000 -1,894,000 -1,874,000 -1,853,000 -1,955,000 -2,060,000 -2,029,000 -1,874,000 -1,907,000 -1,899,000 -1,862,000 -1,204,000 -1,107,000 -826,000 -569,000 -1,205,000 -1,299,000 -1,317,000 -1,759,000 -485,000 -429,000 -429,000 -353,000 -142,000                                                        
      income before income taxes
    		22,714,000 27,620,000 59,982,000 11,511,000         1,401,000 -19,037,000 -13,492,000 -27,445,000 -22,701,000 -21,088,000 -14,791,000 41,271,000                                                            
      provision for income taxes
    		-245,351,000 -280,000 369,000 65,000             -60,000 -136,000 -970,000 1,771,000                                                            
      net income
    		268,065,000 27,900,000 59,613,000 11,446,000 14,341,000 12,421,000 -1,030,000 -8,247,000 737,000 -5,692,000 -6,600,000 -13,536,000 1,401,000 -19,037,000 -13,492,000 -27,445,000 -22,641,000 -20,952,000 -13,821,000 39,500,000 -19,237,000 -14,174,000 -17,576,000 21,243,000 -17,200,000 -11,490,000 -20,606,000 -17,598,000 3,228,000 -23,766,000 -25,557,000 -24,385,000 -17,660,000 -19,147,000 -15,314,000 -22,629,000 -13,533,000 -17,464,000 -12,687,000 -6,672,000 -13,912,000 -18,193,000 -20,942,000 -25,391,000 -22,303,000 -23,824,000 -22,768,000 -23,174,000 -29,881,000 -37,691,000 -34,029,000 -27,262,000 -13,817,500 -18,944,000 -19,245,000 -17,081,000 -5,545,250 -11,382,000   -9,090,750 -12,906,000 -12,293,000 -11,164,000 -10,382,250 -16,136,000 -12,342,000 -13,051,000 -7,333,750 -11,069,000 -10,466,000 -7,800,000 -7,240,000 -10,142,000 -10,446,000 -8,372,000 -6,219,000   
      yoy
    		1769.22% 124.62% -5887.67% -238.79% 1845.86% -318.22% -84.39% -39.07% -47.39% -70.10% -51.08% -50.68% -106.19% -9.14% -2.38% -169.48% 17.70% 47.82% -21.36% 85.94% 11.84% 23.36% -14.70% -220.71% -632.84% -51.65% -19.37% -27.83% -118.28% 24.12% 66.89% 7.76% 30.50% 9.64% 20.71% 239.16% -2.72% -4.01% -39.42% -73.72% -37.62% -23.64% -8.02% 9.57% -25.36% -36.79% -33.09% -15.00% 116.25% 98.96% 76.82% 59.60% 149.18% 66.44%   -39.00% -11.81%   -12.44% -20.02% -0.40% -14.46% 41.57% 45.78% 17.92% 67.32% 1.29% 9.14% 0.19% -6.83% 16.42%       
      qoq
    		860.81% -53.20% 420.82% -20.19% 15.46% -1305.92% -87.51% -1219.00% -112.95% -13.76% -51.24% -1066.17% -107.36% 41.10% -50.84% 21.22% 8.06% 51.60% -134.99% -305.33% 35.72% -19.36% -182.74% -223.51% 49.70% -44.24% 17.09% -645.17% -113.58% -7.01% 4.81% 38.08% -7.77% 25.03% -32.33% 67.21% -22.51% 37.65% 90.15% -52.04% -23.53% -13.13% -17.52% 13.85% -6.38% 4.64% -1.75% -22.45% -20.72% 10.76% 24.82% 97.30% -27.06% -1.56% 12.67% 208.03% -51.28%    -29.56% 4.99% 10.11% 7.53% -35.66% 30.74% -5.43% 77.96% -33.75% 5.76% 34.18% 7.73% -28.61% -2.91% 24.77% 34.62%    
      net income margin %
    		384.04% 40.17% 58.63% 21.46% 24.90% 22.46% -2.80% -27.92% 2.06% -20.23% -24.55% -51.92% 2.73% -84.95% -45.25% -164.00% -110.94% -97.26% -52.62% 48.75% -104.27% -77.08% -109.71% 38.10% -111.69% -55.09% -198.00% -139.40% 8.53% -488.51% -1430.16% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% NaN% NaN% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% NaN% NaN% 
      net income per share
    		      -0.06 -0.05 0.01 -0.03 -0.04 -0.08         -0.12 -0.08 -0.1  -0.1 -0.07 -0.12 -0.11 0.03 -0.14 -0.16 -0.17 -0.14 -0.16 -0.13 -0.24 -0.15 -0.19 -0.14 -0.08 -0.16 -0.21 -0.24 -0.29 -0.25 -0.27 -0.26 -0.32 -0.81 -1.03 -0.93 -0.79 -0.49 -0.61 -0.68 -0.68     -0.435 -0.56 -0.62 -0.57 -0.593 -0.88 -0.68 -0.81 -0.883 -0.78 -1.9 -0.17 -0.163 -0.22 -0.23 -0.19 -0.17   
      basic
    		14.88 1.55 3.33 0.64 0.81 0.71       -0.088 -0.11 -0.08 -0.16 0.008 -0.12 -0.08 0.23    0.13                                                        
      diluted
    		14.1 1.46 3.28 0.63 0.81 0.7       -0.088 -0.11 -0.08 -0.16 0.008 -0.12 -0.08 0.22    0.13                                                        
      weighted-average shares used for eps calculation
    		      17,549 175,203 174,017 174,364 173,748 173,568 172,406    170,492    168,754 168,932   167,400 167,609 167,191 167,173 160,529 166,464 161,577 147,114 124,628 122,500 113,598 95,454 92,495 90,555 88,434 88,506 88,137 88,043 87,793 87,532 87,526 87,430 87,147 71,422 36,704 36,581 36,505 34,417  31,030 28,355 25,184  24,987,000 24,842,000 24,816,000 21,857,000 23,235 19,887 19,713  18,386 18,215 16,047  14,224 5,496 45,798  45,515 45,339 43,312 37,516   
      basic
    		17,987 18,038 17,885 17,808 17,579 17,600        172,836 172,147 171,774  170,886 170,192 169,800   168,570 168,469                                                        
      diluted
    		18,840 19,156 18,162 18,169 17,687 17,648        172,836 172,147 171,774  170,886 170,192 176,069   168,570 168,568                                                        
      government contracts
    		                                                                               
      net income per share
    		      -0.06 -0.05 0.01 -0.03 -0.04 -0.08         -0.12 -0.08 -0.1  -0.1 -0.07 -0.12 -0.11 0.03 -0.14 -0.16 -0.17 -0.14 -0.16 -0.13 -0.24 -0.15 -0.19 -0.14 -0.08 -0.16 -0.21 -0.24 -0.29 -0.25 -0.27 -0.26 -0.32 -0.81 -1.03 -0.93 -0.79 -0.49 -0.61 -0.68 -0.68     -0.435 -0.56 -0.62 -0.57 -0.593 -0.88 -0.68 -0.81 -0.883 -0.78 -1.9 -0.17 -0.163 -0.22 -0.23 -0.19 -0.17   
      weighted-average shares used for eps calculation
    		      17,549 175,203 174,017 174,364 173,748 173,568 172,406    170,492    168,754 168,932   167,400 167,609 167,191 167,173 160,529 166,464 161,577 147,114 124,628 122,500 113,598 95,454 92,495 90,555 88,434 88,506 88,137 88,043 87,793 87,532 87,526 87,430 87,147 71,422 36,704 36,581 36,505 34,417  31,030 28,355 25,184  24,987,000 24,842,000 24,816,000 21,857,000 23,235 19,887 19,713  18,386 18,215 16,047  14,224 5,496 45,798  45,515 45,339 43,312 37,516   
      government contract
    		        250,000  1,000,000  2,000,000 2,500,000   1,000,000 1,000,000 5,500,000 3,000,000                                                            
      gain on disposal of assets
    		                                  732,000     55,000                                        
      general and administrative
    		                               13,492,000 7,947,000 7,820,000 7,410,000 4,558,000 4,774,000 4,423,000 4,721,000 4,276,000 4,099,000 4,717,000 4,889,000 5,393,000 5,516,000 4,677,000 4,892,000 6,156,000 5,050,000 7,450,000 6,861,000 7,125,000 3,866,500 5,054,000 5,373,000 5,039,000 5,020,000 4,804,000 4,725,000 5,003,000 2,724,000 3,383,000 3,429,000 2,874,000 2,342,500 3,711,000 2,746,000 2,913,000 1,551,750 2,161,000 2,012,000 2,034,000 1,833,750 2,130,000 2,761,000 2,444,000 1,991,000   
      restructuring charges
    		                                   5,770,000          1,679,000                                  
      contract revenues
    		                                                    1,150,000  1,956,000 2,644,000                        
      income tax benefit
    		                                                27,000                               
      net income per common share, basic and diluted
    		                                                        -222.5 -460 -90 -340                    
      loss on sale of property and equipment
    		                                                                               
      deemed dividend to series e preferred stockholders
    		                                                                               
      net income allocable to common stockholders
    		                                                                            -6,219,000   
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-09-30 2018-06-30 2018-03-31 2017-09-30 2017-06-30 2017-03-31 2016-09-30 2016-06-30 2016-03-31 2015-09-30 2015-06-30 2015-03-31 2014-06-30 2014-03-31 2013-09-30 2013-06-30 2003-09-30 
                                                   
        assets
      		                                             
        current assets:
      		                                             
        cash and cash equivalents
      		40,580,000 48,534,000 53,407,000 45,728,000 56,746,000 51,692,000 36,053,000 25,574,000 32,786,000 45,414,000 48,812,000 40,285,000 24,459,000 29,866,000 27,201,000 24,679,000 18,890,000 30,403,000 84,823,000 20,047,000 30,373,000 36,567,000 36,469,000 45,225,000 22,521,000 39,093,000 44,229,000 74,696,000 61,486,000 65,078,000 40,125,000 25,879,000 32,591,000 40,144,000 25,950,000 24,946,000 14,269,000 38,577,000 17,290,000 42,718,000 23,882,000 14,910,000 16,031,000 21,868,000 24,067,000 
        short-term investments
      		114,375,000 88,609,000 54,972,000 31,371,000 20,575,000 9,422,000 13,049,000 23,976,000 24,147,000 16,937,000 15,545,000 18,377,000 33,747,000 51,776,000 61,965,000 82,840,000 106,077,000 112,743,000 68,564,000 19,298,000 26,954,000 36,245,000 56,028,000 50,701,000 75,557,000 68,387,000 68,148,000 53,227,000 54,151,000 69,914,000 54,175,000 42,197,000 49,711,000 57,997,000 59,305,000 69,994,000 89,363,000 95,773,000 126,652,000 118,437,000      
        accounts receivable
      		51,763,000 45,925,000 39,907,000 41,547,000 41,615,000 30,575,000 28,904,000 27,512,000 30,550,000 23,546,000 20,819,000 29,366,000 40,320,000 15,525,000 17,198,000 15,240,000 15,472,000 14,991,000 17,372,000 142,195,000 15,973,000 14,631,000 11,727,000 9,660,000 10,111,000 11,552,000 6,933,000 5,614,000 3,273,000 1,620,000      95,000 195,000 163,000 350,000 106,000     1,719,000 
        inventories
      		11,506,000 13,303,000 10,423,000 4,659,000 6,002,000 4,784,000 8,059,000 6,579,000 5,522,000 6,112,000 10,782,000 11,077,000 9,118,000 7,116,000 6,218,000 6,764,000 6,616,000 7,035,000 6,833,000 6,947,000 1,638,000 2,050,000 1,684,000 1,622,000 1,354,000 1,181,000 1,222,000 1,130,000 534,000 494,000                
        prepaid and other current assets
      		21,942,000 18,556,000 16,684,000 23,258,000 10,165,000 9,994,000 8,658,000 8,845,000 6,261,000 3,015,000 4,967,000 7,867,000 8,259,000 6,157,000 7,939,000 9,415,000 7,412,000 5,932,000 6,606,000 8,271,000 14,045,000 10,355,000 7,182,000 9,124,000 9,462,000 5,789,000 3,972,000 4,652,000 1,562,000 1,551,000 2,320,000 1,485,000 1,490,000 1,383,000 1,292,000 1,862,000 1,779,000 1,667,000 1,230,000 1,261,000 1,510,000 2,444,000    
        total current assets
      		240,166,000 214,927,000 175,393,000 146,563,000 135,103,000 106,467,000 94,723,000 92,486,000 99,266,000 95,024,000 100,925,000 106,972,000 115,903,000 110,440,000 120,521,000 138,938,000 154,467,000 171,104,000 184,198,000 196,758,000 88,983,000 99,848,000 113,090,000 116,332,000 119,005,000 126,002,000 124,504,000 139,319,000 121,036,000 139,057,000 96,620,000 69,561,000 83,792,000 99,524,000 86,547,000 96,897,000 105,606,000 136,180,000 145,522,000 162,522,000 177,540,000 197,828,000 233,013,000 254,576,000 60,465,000 
        intangible assets
      		24,748,000 25,336,000 25,924,000 26,512,000 27,100,000 27,687,000 28,275,000 28,863,000                                      
        deferred income tax asset
      		245,852,000                                             
        operating lease right-of-use assets
      		920,000 1,050,000 1,178,000 1,305,000 246,000 405,000 560,000 712,000 861,000 1,008,000 997,000 1,123,000 1,930,000                                 
        other assets
      		1,908,000 1,167,000 4,184,000 1,516,000 1,435,000 4,761,000 4,735,000 4,318,000 3,055,000 4,956,000 541,000 542,000 640,000 484,000 403,000 464,000 974,000 935,000 840,000 818,000 824,000 820,000 653,000 661,000 696,000 695,000 713,000 729,000 652,000 678,000 754,000 770,000 704,000 730,000 800,000 842,000 1,064,000 1,173,000 1,021,000 1,061,000 1,461,000 1,484,000 1,586,000 1,644,000 2,095,000 
        total assets
      		513,594,000 242,534,000 206,736,000 175,972,000 163,976,000 139,419,000 128,408,000 126,519,000 117,225,000 115,324,000 117,091,000 123,612,000 134,279,000                                 
        liabilities and stockholders’ equity
      		                                             
        current liabilities:
      		                                             
        accounts payable
      		7,191,000 3,846,000 7,290,000 3,954,000 3,339,000 3,815,000 6,130,000 9,276,000 7,142,000 7,999,000 5,240,000 6,295,000 22,508,000 2,721,000 2,155,000 4,614,000 3,795,000 3,144,000 1,689,000 5,095,000 3,707,000 2,283,000 3,414,000 2,207,000 4,152,000 2,661,000 3,777,000 1,179,000 2,641,000 3,342,000 2,623,000 2,193,000 2,066,000 1,178,000 1,518,000 1,506,000 2,424,000 689,000 1,096,000 1,136,000 1,896,000 1,157,000 1,025,000 2,121,000 1,344,000 
        accrued compensation
      		11,914,000 10,065,000 7,897,000 6,024,000 10,139,000 7,924,000 6,373,000 5,246,000 8,676,000 8,093,000 6,739,000 5,661,000 8,866,000 8,773,000 7,525,000 6,628,000 10,690,000 9,461,000 7,764,000 6,595,000 9,592,000 8,173,000 7,293,000 5,507,000 8,819,000 7,066,000 5,863,000 4,432,000 7,499,000 5,440,000 4,746,000 4,743,000 3,659,000 2,621,000 4,552,000 3,119,000 3,152,000 4,361,000 4,000,000 3,714,000 3,172,000 2,475,000 2,874,000 2,703,000 917,000 
        accrued research and development
      		5,524,000 4,816,000 4,121,000 4,648,000 4,073,000 3,593,000 4,672,000 4,127,000 3,513,000 5,754,000 5,826,000 6,940,000 7,708,000 7,574,000 9,213,000 9,492,000 10,384,000 9,475,000 6,464,000 5,368,000 4,889,000 3,296,000 5,147,000 6,695,000 5,960,000 5,631,000 5,447,000 6,999,000 5,801,000 5,494,000 5,872,000 4,408,000 5,171,000 6,230,000 7,686,000 6,702,000 7,239,000 5,199,000 4,293,000 4,448,000 2,770,000 2,312,000 2,679,000 2,021,000  
        acquisition related liabilities
      		5,000,000                                             
        revenue reserves and refund liability
      		27,716,000 30,020,000 29,502,000 27,935,000 26,440,000 22,192,000 18,547,000 16,045,000 15,684,000 14,543,000 13,684,000 14,088,000 12,145,000                                 
        loans payable, net, current portion
      		29,812,000 29,761,000 22,361,000 14,815,000 7,272,000   14,780,000 7,229,000                                     
        other current liabilities
      		11,466,000                                             
        lease liabilities, current portion
      		614,000 594,000 517,000 456,000 285,000 466,000 639,000 709,000 692,000 673,000 466,000 449,000 1,133,000 3,314,000 5,811,000 8,296,000 9,892,000 9,574,000 9,221,000 8,917,000 8,621,000 8,334,000 8,054,000 7,780,000 7,272,000 7,255,000 7,002,000 6,755,000                  
        total current liabilities
      		99,237,000 94,400,000 86,636,000 66,629,000 63,299,000 54,312,000 58,649,000 73,198,000 53,267,000 48,273,000 44,023,000 45,518,000 65,211,000 47,265,000 54,955,000 59,225,000 63,554,000 59,282,000 59,544,000 52,022,000 40,841,000 34,192,000 34,760,000 31,172,000 58,212,000 31,006,000 28,380,000 26,138,000 19,696,000 17,365,000 18,790,000 15,006,000 15,873,000 17,245,000 20,632,000 22,001,000 27,711,000 34,838,000 34,174,000 34,349,000 10,065,000 7,865,000 8,303,000 8,472,000 9,030,000 
        acquisition-related liabilities
      		 5,000,000 5,000,000 5,000,000 5,000,000 5,000,000 15,000,000 15,222,000                                      
        long-term portion of lease liabilities
      		395,000 556,000 714,000 864,000    100,000 285,000 466,000 628,000 802,000 972,000    759,000 3,314,000 5,854,000 8,296,000 10,651,000 12,929,000 15,249,000 17,305,000 19,230,000 21,179,000 23,086,000 24,950,000                  
        long-term portion of loans payable
      		22,482,000 29,969,000 37,452,000 44,931,000 52,408,000 59,762,000 59,692,000 44,910,000 52,373,000                                     
        other long-term liabilities
      		   39,981,000 39,981,000 39,981,000 39,981,000 39,982,000 39,944,000 38,760,000 40,981,000 42,065,000 42,264,000 48,710,000 46,888,000 53,204,000 52,727,000 54,365,000 48,230,000 57,533,000 5,045,000 5,000,000 5,000,000 5,000,000 5,098,000     38,000 38,000 77,000   8,000 15,000 21,000 33,000 39,000 46,000 63,000 69,000 80,000 85,000 533,000 
        total liabilities
      		122,114,000 124,925,000 124,802,000 157,405,000 160,688,000 154,055,000 158,322,000 158,190,000 145,869,000 147,158,000 145,206,000 147,869,000 147,895,000                                 
        commitments
      		                                             
        stockholders’ equity:
      		                                             
        preferred stock, 0.001 par value...
      		                                             
        common stock, 0.001 par value...
      		18,000        175,000    174,000    172,000    169,000    168,000                    15,000 
        additional paid-in capital
      		1,414,322,000 1,408,601,000 1,400,916,000 1,397,170,000 1,393,325,000 1,389,742,000 1,386,905,000 1,383,956,000 1,378,723,000 1,376,293,000 1,374,330,000 1,371,591,000 1,368,822,000 1,364,139,000 1,361,411,000 1,358,373,000 1,354,190,000 1,350,736,000 1,348,225,000 1,344,601,000 1,339,833,000 1,337,519,000 1,335,556,000 1,333,237,000 1,329,852,000 1,327,735,000 1,325,618,000 1,322,070,000 1,315,894,000 1,312,246,000 1,242,985,000 1,169,032,000 1,164,823,000 1,160,163,000 1,111,107,000 1,096,215,000 1,084,422,000 1,075,251,000 1,073,339,000 1,070,418,000 1,062,571,000 1,059,778,000 1,055,599,000 1,053,536,000 195,168,000 
        accumulated other comprehensive income
      		181,000 96,000 6,000 -2,000 10,000 11,000 -9,000 -5,000 8,000        -102,000 8,000   -4,000 2,000 46,000 78,000 23,000 36,000 43,000 10,000          25,000 11,000 17,000 42,000 38,000 129,000 17,000  
        accumulated deficit
      		-1,023,041,000 -1,291,106,000 -1,319,006,000 -1,378,619,000 -1,390,065,000 -1,404,406,000 -1,416,827,000 -1,415,797,000 -1,407,550,000 -1,408,287,000 -1,402,595,000 -1,395,995,000 -1,382,459,000 -1,383,860,000 -1,364,823,000 -1,351,331,000 -1,323,886,000 -1,301,245,000 -1,280,293,000 -1,266,472,000 -1,305,972,000 -1,286,735,000 -1,272,561,000 -1,254,985,000 -1,276,228,000 -1,259,028,000 -1,247,538,000 -1,226,932,000 -1,212,562,000 -1,188,796,000 -1,163,239,000 -1,112,983,000 -1,095,323,000 -1,076,176,000 -1,045,272,000 -1,022,643,000 -1,009,110,000 -978,959,000        
        total stockholders’ equity
      		391,480,000 117,609,000 81,934,000 18,567,000 3,288,000         -19,834,000 -3,677,000 6,798,000 30,374,000 49,670,000 68,110,000 78,298,000 34,026,000 50,955,000 63,210,000 78,499,000 53,815,000 68,911,000 78,291,000 95,315,000 103,473,000 123,567,000 79,807,000 56,167,000 69,605,000 84,081,000 65,943,000 73,720,000 75,452,000 96,406,000 101,151,000 112,148,000 165,733,000 188,327,000 223,402,000 245,051,000 50,738,000 
        total liabilities and stockholders’ equity
      		513,594,000 242,534,000 206,736,000 175,972,000 163,976,000                                         
        property and equipment
      		 54,000 57,000 76,000 92,000 99,000 115,000 140,000 165,000 190,000 215,000 294,000 857,000 1,694,000 1,832,000 2,140,000 2,184,000 2,655,000 2,665,000 2,498,000 2,676,000 2,517,000 2,381,000 2,595,000 2,159,000 1,718,000 1,532,000 1,600,000 1,481,000 1,484,000 1,439,000 919,000 982,000 1,072,000 1,294,000 1,581,000 1,610,000 1,817,000 1,810,000 2,106,000 3,430,000 3,978,000 4,938,000 5,454,000 3,933,000 
        other accrued liabilities
      		 8,943,000 8,593,000 7,442,000 10,396,000 9,967,000 5,933,000 5,435,000 5,334,000 5,030,000 5,013,000 5,096,000 6,485,000 17,602,000 16,885,000 16,505,000 12,691,000 13,486,000 12,359,000 11,075,000 11,014,000 9,037,000 7,637,000 6,930,000 6,721,000 6,806,000 4,929,000 5,241,000 3,755,000 3,089,000 5,549,000 1,517,000 996,000 1,472,000 1,041,000 1,269,000 847,000 1,241,000 545,000 992,000 731,000 571,000 652,000 690,000  
        deferred revenue
      		 1,355,000 1,355,000 1,355,000 1,355,000 1,355,000 1,355,000 1,355,000 1,355,000 1,355,000 1,355,000 1,369,000 1,369,000 1,369,000 1,543,000 2,097,000 2,596,000 3,157,000                  3,760,000 8,593,000 18,261,000       3,194,000 
        common stock
      		 18,000 18,000 18,000  17,000 17,000 175,000  175,000 175,000 174,000  173,000 173,000 172,000  171,000 171,000 170,000  169,000 169,000 169,000  168,000 168,000 167,000 166,000 166,000 148,000 125,000 124,000 123,000 99,000 95,000 91,000 89,000 88,000 88,000 88,000 88,000 87,000 87,000  
        other long-term liabilities, current portion
      		       1,003,000 3,642,000 4,826,000 5,700,000 5,620,000 4,997,000 5,912,000 11,823,000 11,593,000 13,506,000 10,985,000 16,234,000 5,472,000                          
        stockholders’ equity
      		                                             
        common stock , 0.001 par value...
      		    18,000                                         
        liabilities and stockholders’ deficit
      		                                             
        stockholders’ deficit:
      		                                             
        total stockholders’ deficit
      		     -14,636,000 -29,914,000 -31,671,000 -28,644,000 -31,834,000 -28,115,000 -24,257,000                                  
        total liabilities and stockholders’ deficit
      		     139,419,000 128,408,000 126,519,000 117,225,000 115,324,000 117,091,000 123,612,000                                  
        preferred stock
      		                                             
        intangible asset
      		        13,878,000 14,146,000 14,413,000 14,681,000 14,949,000                                 
        loans payable, net of discount
      		         59,659,000 59,574,000 59,484,000 39,448,000 39,468,000 29,835,000 29,847,000 19,914,000 19,887,000 19,860,000 19,844,000 19,815,000 19,836,000 19,816,000 9,829,000 9,810,000 9,789,000                    
        accumulated other comprehensive loss
      		         -15,000 -25,000 -27,000 -153,000 -286,000 -438,000 -416,000   7,000 -1,000         -25,000 -49,000 -87,000  -19,000 -29,000            
        liabilities and stockholders’ (deficit) equity
      		                                             
        total stockholders’ (deficit) equity
      		            -13,616,000                                 
        total liabilities and stockholders’ (deficit) equity
      		            134,279,000                                 
        operating lease right-of-use asset
      		             2,991,000 5,245,000 7,532,000 9,703,000 11,824,000 13,895,000 15,919,000 17,895,000 19,873,000 21,911,000 23,775,000 25,709,000 27,646,000 29,409,000 31,136,000                  
        deferred revenue, current portion
      		                  5,813,000 9,500,000 3,018,000 3,069,000 3,215,000 2,053,000 25,288,000 1,587,000 1,362,000 1,532,000           19,335,000 19,335,000      
        long-term portion of deferred revenue
      		                     146,000  1,558,000 1,404,000 25,176,000 26,401,000 26,381,000           3,760,000 8,593,000     779,000 
        long-term portion of deferred rent
      		                             249,000 178,000    994,000 1,707,000 2,421,000 3,662,000 4,240,000 4,819,000 6,570,000 7,029,000 7,752,000 8,066,000  
        deferred rent
      		                            30,000 400,000               3,852,000 
        deferred liability – sublease, current portion
      		                               1,248,000 2,196,000 3,127,000 3,167,000 3,112,000 3,058,000 2,953,000        
        deferred rent, current portion
      		                               897,000 1,785,000 2,617,000 2,668,000 2,533,000 2,398,000 2,134,000 2,003,000 1,872,000 1,496,000 1,350,000  937,000  
        long-term portion of deferred liability – sublease
      		                                  1,064,000 1,877,000 2,675,000 4,231,000        
        accumulated other comprehensive gain
      		                                  9,000 53,000 49,000         
        deferred liability - sublease, current portion
      		                                      2,902,000 2,852,000      
        long-term portion of deferred liability - sublease
      		                                      4,989,000 5,734,000      
        available-for-sale securities
      		                                        152,148,000 180,474,000 214,851,000 229,773,000 32,786,000 
        commitments and contingencies
      		                                             
        prepaid expenses and other current assets
      		                                          2,131,000 2,935,000 1,843,000 
        deferred rent - current portion
      		                                          1,073,000   
        receivable from landlord
      		                                            50,000 
        accrued liabilities
      		                                            1,111,000 
        capital lease obligations
      		                                            2,464,000 
        deferred stock compensation
      		                                             
        less treasury stock, at cost: 4,525 and no shares at september 30, 2003 and december 31, 2002, respectively
      		                                             
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-09-30 2017-06-30 2017-03-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-09-30 2014-06-30 2014-03-31 2013-09-30 2013-06-30 2012-03-31 2008-09-30 2008-06-30 2008-03-31 2007-09-30 2007-06-30 2007-03-31 2006-12-31 2006-09-30 2006-06-30 2006-03-31 2005-12-31 2005-09-30 2005-06-30 2005-03-31 2004-09-30 2004-06-30 2004-03-31 2003-09-30 2003-06-30 2003-03-31 2002-09-30 2002-06-30 2002-03-31 
                                                                               
          operating activities
        		                                                                       
          net income
        		268,065,000 27,900,000 59,613,000 11,446,000 14,341,000         -19,037,000 -13,492,000 -27,445,000  -20,952,000 -13,821,000 39,500,000   -17,576,000 21,243,000    -17,598,000 3,228,000 -23,766,000 -25,557,000 -24,385,000 -17,660,000 -19,147,000 -15,314,000 -22,629,000 -13,533,000 -17,464,000 -12,687,000 -6,672,000 -13,912,000 -18,193,000 -20,942,000 -25,391,000 -22,303,000 -23,824,000 -25,168,000 -23,174,000 -37,691,000 -34,029,000 -27,262,000 -18,944,000 -19,245,000 -17,081,000 22,143,363 -11,382,000 -2,330,000 -8,469,000 -8,893,000 -12,906,000 -12,293,000 -11,164,000 -16,136,000 -12,342,000 -13,051,000  -10,466,000 -7,800,000 -10,142,000 -10,446,000 -8,372,000 
          adjustments to reconcile net income to net cash from operating activities:
        		                                                                       
          stock-based compensation expense
        		2,748,000 3,363,000 3,276,000 3,324,000 2,087,000 2,644,000 2,528,000 5,134,000 1,933,000 1,943,000 2,172,000 2,758,000 4,080,000 2,707,000 2,391,000 3,207,000 2,339,000 2,202,000 2,306,000 2,639,000 1,632,000 1,884,000 1,757,000 2,024,000 1,411,000 2,098,000 2,653,000 2,953,000 2,057,000   1,540,000 873,000 1,100,000 955,000 1,215,000 2,014,000 1,438,000 1,625,000 1,815,000 1,909,000 2,054,000 2,080,000 2,132,000 2,364,000 2,063,000 442,000 3,098,000 6,036,000 5,919,000 5,846,000 2,794,000 3,705,000 2,622,000                  
          loss on sale and disposal of fixed assets
        		    -56,000    -110,000 -22,000 51,000 347,000                                                            
          depreciation and amortization
        		601,000 603,000 607,000 604,000 604,000 611,000 613,000 400,000 293,000 292,000 296,000 357,000 284,000 240,000 237,000 237,000 404,000 261,000 258,000 239,000 206,000 165,000 164,000 171,000 180,000 166,000 173,000 164,000 163,000 159,000 159,000 113,000 112,000 114,000 126,000 214,000 260,000 324,000 338,000 287,000 379,000 435,000 574,000 623,000 655,000 644,000 745,000 552,000 354,000 368,000 342,000 335,000 338,000 336,000 -987,582 325,000 330,000 334,000 467,000 96,000 282,000 305,000 477,000 503,000 573,000 622,000 670,000 779,000 1,218,000 1,211,000 1,242,000 
          deferred income tax benefit
        		                                                                       
          release of cost share liability
        		0 0                                                                      
          net amortization of discount on short-term investments and term loans
        		-243,000 -467,000 -250,000 -190,000 -276,000 -69,000                                                                  
          changes in assets and liabilities:
        		                                                                       
          accounts receivable
        		-5,838,000 -6,018,000 1,640,000 68,000 -11,040,000 -1,671,000 -1,392,000 3,038,000 -7,004,000 -2,727,000 8,547,000 10,954,000 -24,795,000 1,673,000 -1,958,000 232,000 -481,000 2,381,000 124,823,000 -126,222,000 -1,342,000 -2,904,000 -2,067,000 451,000 1,441,000 -4,619,000 -1,319,000 -1,537,000 -804,000 -1,653,000      95,000 100,000 8,000 -40,000 187,000 -244,000 5,644,000 0 0 5,750,000       485,000           0 377,000 123,000  754,000 32,000    
          inventories
        		1,131,000 188,000 -8,367,000 1,413,000 1,925,000 3,344,000 -2,195,000 -2,310,000 2,531,000 281,000 309,000 -1,949,000 -1,983,000 -877,000 595,000 -112,000 450,000 -167,000 114,000 -5,272,000 109,000 42,000 -35,000 -242,000 -171,000 50,000 -42,000 -203,000 -341,000 -22,000                                          
          prepaid and other current and non-current assets
        		-3,387,000 -1,872,000 6,561,000 -13,150,000 44,000 -1,396,000                                                                  
          right-of-use assets
        		130,000 128,000 127,000 -1,059,000 159,000 155,000 152,000 149,000 147,000 -11,000 126,000 807,000 1,061,000 2,254,000 2,287,000 2,171,000 2,121,000 2,071,000 2,024,000 1,976,000                                                    
          accounts payable
        		3,345,000 -3,444,000 3,336,000 615,000 -476,000 -2,315,000 -3,146,000 2,134,000 -857,000 2,759,000 -1,055,000 -1,213,000 4,787,000 586,000 -2,435,000 850,000 697,000 1,374,000 -3,424,000 1,394,000 1,538,000 -1,131,000 1,207,000 -1,945,000 1,491,000 -1,116,000 2,598,000 -5,212,000 3,750,000 -701,000 1,199,000 -493,000 118,000 877,000 -4,385,000 18,000 -924,000 -339,000 2,074,000        58,000 366,000    146,000      40,000 -241,000 -447,000 862,000 378,000 -61,000 1,144,000 22,000    854,000 -1,577,000 2,331,000 
          accrued compensation
        		1,849,000 2,168,000 1,873,000 -4,115,000 2,215,000 1,551,000 1,127,000 -3,430,000 583,000 1,354,000 1,078,000 -3,205,000 93,000 1,248,000 897,000 -4,062,000 1,229,000 1,697,000 1,169,000 -2,997,000 1,419,000 880,000 1,786,000 -3,312,000 1,753,000 1,203,000 1,431,000 -5,520,000 2,453,000 2,059,000 694,000 -2,313,000 1,084,000 1,038,000 -1,464,000 1,433,000 -33,000 -3,099,000 1,890,000 361,000 286,000 882,000 464,000                    611,000 -144,000 344,000 57,000 -31,000 92,000 105,000 -184,000 349,000 
          accrued research and development
        		708,000 695,000 -527,000 575,000 480,000 -1,079,000 545,000 614,000 -2,241,000 -72,000 -1,114,000 -768,000 134,000 -1,639,000 -279,000 -892,000 909,000 3,011,000 1,096,000 479,000 1,593,000 -1,851,000 -1,548,000 735,000 329,000 184,000 -1,552,000 236,000 962,000 307,000 -378,000 844,000 -763,000 -1,059,000 349,000 984,000 -537,000 2,286,000 -246,000 906,000 -155,000 455,000 256,000 458,000 724,000                           
          revenue reserves and refund liability
        		-2,304,000 518,000 1,567,000 1,495,000 4,248,000 3,645,000 2,502,000 361,000 1,141,000 859,000 -404,000 1,943,000                                                            
          other current and long-term liabilities
        		        0 -2,218,000 -77,000 1,252,000 -4,680,000 0      57,900,000                                                    
          lease liability
        		  -89,000 1,035,000 -181,000 -173,000 -170,000 -168,000 -162,000 45,000 -157,000 -854,000 -1,209,000 -2,497,000 -2,485,000 -2,355,000 -2,237,000 -2,187,000 -2,138,000 -2,059,000 -1,991,000 -2,040,000 -1,782,000 -1,417,000 -1,932,000 -1,654,000 -1,617,000 -1,522,000                                            
          net cash from operating activities
        		21,980,000 24,031,000 30,537,000 -893,000 14,503,000 21,679,000 302,000 -5,013,000 -6,240,000 -1,359,000 5,930,000 -4,074,000 -21,909,000 -13,301,000 -12,911,000 -25,637,000 -19,086,000 -10,297,000 55,216,000 -19,955,000 -15,572,000 -19,482,000 -14,038,000 -3,093,000 -9,649,000 -14,641,000 -16,651,000 -569,000 11,644,000 -20,082,000 -26,994,000 -23,394,000 -17,610,000 -19,470,000 -20,762,000 -22,571,000 -18,434,000 -22,420,000 -13,797,000   17,987,000                              
          investing activities
        		                                                                       
          maturities of short-term investments
        		13,549,000 20,730,000 15,750,000 11,100,000 6,750,000 6,000,000 18,700,000 8,250,000 6,000,000 8,250,000 11,750,000 15,650,000 21,166,000 29,417,000 20,795,000 29,850,000 30,850,000 1,399,000 17,901,000 11,900,000 27,250,000 40,414,000 24,350,000 38,420,000 37,820,000 40,681,000 25,450,000 19,175,000 30,100,000 24,450,000 20,866,000 28,650,000 26,932,000 19,905,000 32,544,000 25,273,000 39,822,000 40,996,000 54,765,000 57,977,000 24,600,000 59,520,000                              
          purchases of short-term investments
        		-38,923,000 -53,893,000 -39,026,000 -21,652,000 -17,710,000 -2,214,000 -7,549,000 -7,799,000 -12,984,000 -9,442,000   -2,845,000 -19,052,000 0 -6,997,000 -24,383,000 -45,626,000 -67,153,000 -4,297,000 -18,035,000 -20,691,000 -29,628,000 -13,352,000 -44,826,000 -40,623,000 -40,007,000 -19,871,000 -27,938,000 -8,439,000 -36,384,000 -5,235,000 -19,315,000 -11,535,000 -33,385,000 -14,628,000 -20,449,000 -47,446,000 -41,881,000                                 
          capital expenditures
        		0 0 0 0 -26,000 0 0 0 0 0 0  0 -189,000 36,000 -224,000 21,000 -170,000 -407,000 -71,000 -504,000 -195,000 44,000 -607,000 -611,000 -352,000 -115,000 -377,000 -69,000 -156,000 -684,000 -197,000 -56,000 -14,000 -41,000 -252,000 -225,000 -321,000 -134,000   0                              
          free cash flows
        		21,980,000 24,031,000 30,537,000 -893,000 14,477,000 21,679,000 302,000 -5,013,000 -6,240,000 -1,359,000 5,930,000  -21,909,000 -13,490,000 -12,875,000 -25,861,000 -19,065,000 -10,467,000 54,809,000 -20,026,000 -16,076,000 -19,677,000 -13,994,000 -3,700,000 -10,260,000 -14,993,000 -16,766,000 -946,000 11,575,000 -20,238,000 -27,678,000 -23,591,000 -17,666,000 -19,484,000 -20,803,000 -22,823,000 -18,659,000 -22,741,000 -13,931,000   17,987,000                              
          payments for acquisition of intangible assets
        		    0 0 -222,000 -138,000                                                                
          proceeds from sale of property and equipment
        		    72,000    110,000 22,000 0 127,000                                                            
          net cash from investing activities
        		-25,362,000 -33,175,000 -23,276,000 -10,552,000 -10,914,000 3,802,000 10,929,000 313,000 -6,874,000 -1,170,000 2,970,000 777,000 18,598,000 10,455,000 21,095,000 22,629,000 6,488,000 -44,397,000 -49,659,000 7,532,000 8,711,000 19,528,000 -5,234,000 24,461,000 -7,617,000 -294,000 -14,672,000 -1,073,000 2,093,000 15,855,000 -16,202,000 23,218,000 7,561,000 8,356,000 -150,000 10,393,000 19,148,000 -6,771,000 12,750,000 30,646,000 -8,294,000 9,511,000 7,258,000 28,255,000 10,460,000 14,906,000 7,809,000 26,185,000      10,855,000 -1,223,052 436,000                
          financing activities
        		                                                                       
          net proceeds from term loan financing
        		        0 0 0 19,950,000 0 9,600,000 -33,000 9,975,000     0 0   0                                               
          principal payments of term loans
        		                                                                       
          net proceeds from issuance of common stock from equity plans
        		2,928,000 4,271,000 418,000 484,000                                                                    
          closing purchase price payment related to asset acquisition
        		    0                                                                   
          cost share payments to a collaboration partner
        		    0 0 -1,004,000 -2,601,000 0 -878,000 -926,000 -828,000 -2,681,000                                                           
          net cash from financing activities
        		-4,572,000 4,271,000 418,000 484,000 1,465,000 -9,842,000 -752,000 -2,512,000 486,000 -869,000 -373,000 19,123,000 -2,096,000 5,511,000 -5,662,000 8,797,000 1,085,000 274,000 59,219,000 2,097,000 667,000 52,000 10,516,000 1,336,000 694,000 9,799,000 856,000 16,000 1,099,000 635,000 68,149,000 2,011,000 3,337,000 3,561,000 43,424,000 13,182,000 9,963,000 4,000 5,926,000 98,000 1,012,000 17,000 5,000 661,000 24,000 0 334,000 488,000 447,000 1,563,000 128,399,000 -217,000 52,819,000 21,000 -2,361,164 925,000 729,000 710,000 16,046,000 81,543,000 371,000 5,645,000 1,122,000 -53,000 57,973,000 8,485,000   -462,000 587,000 30,853,000 
          net increase in cash, cash equivalents and restricted cash
        		-7,954,000 -4,873,000                                                                      
          cash and cash equivalents at beginning of period
        		0 0 0 56,746,000 0 0 0 32,786,000 0 0 0 24,459,000 0 0 0 18,890,000 0 0 0 30,373,000 0 0 0 22,521,000 0 0 0 76,322,000 0 0 0 38,290,000 0 0 17,632,000 0 0 43,456,000 0 0 0 15,203,000 0 0 20,854,000 0 14,851,000 18,633,000 0 0 44,503,000 0 0 47,727,000 -76,702,221 0 0 76,779,000 0 0 0 10,495,000 0 0 9,621,000 0 0 26,535,000 0 0 11,488,000 
          cash, cash equivalents, and restricted cash at end of period
        		-7,954,000 -4,873,000 7,679,000 45,785,000                                                                    
          supplemental disclosure of cash flow information
        		                                                                       
          interest paid
        		1,564,000 1,677,000 1,679,000 1,653,000 1,747,000 1,835,000 1,773,000 1,684,000 1,681,000 1,682,000 1,474,000 1,011,000 946,000 598,000 558,000 393,000 406,000 371,000 365,000 358,000 366,000 366,000 245,000 203,000                                                
          income taxes paid
        		                                                                       
          increase in right-of-use assets and lease liability
        		  0 1,220,000                                                                    
          acquisition-related liabilities
        		0 0 0 5,000,000 0                                                                   
          gain on sale and disposal of fixed assets
        		                                                                       
          other accrued liabilities
        		 350,000 1,151,000 -2,954,000 429,000 4,034,000 431,000 101,000 304,000 17,000 -83,000 -1,389,000 -3,202,000 717,000 380,000 3,814,000 -737,000 1,127,000 1,375,000 61,000 2,320,000 913,000 609,000 209,000 -85,000 1,877,000 -312,000 1,642,000 -156,000 666,000 -2,425,000 2,184,000 484,000 -476,000 439,000 -228,000 422,000 -286,000 28,000 570,000 -457,000 458,000      199,000 2,011,000 3,942,000 974,000   924,000     578,000 -322,000     203,000       
          lease liabilities
        		                                                                       
          increase in right-of-use assets and lease liabilities
        		                                                                       
          net decrease in cash, cash equivalents and restricted cash
        		   -10,961,000                                                                    
          non-cash interest expense
        		            0 0 0 682,000 825,000 886,000 1,368,000 60,000                                                    
          deferred revenue
        		        0 0   0 -174,000 -554,000 -499,000 -561,000 -2,656,000 -3,687,000 6,482,000 -152,000 0 -396,000 -23,081,000 -71,000 -1,000,000 -150,000 25,476,000        -3,760,000 -4,833,000 -4,834,000 -4,834,000 -4,834,000 -4,833,000 27,928,000                 5,530,000 -2,232,000 -2,229,000 9,361,000         788,000 
          net increase in cash and cash equivalents
        		    5,054,000 15,639,000 10,479,000 -7,212,000 -12,628,000 -3,398,000 8,527,000 15,826,000 -5,407,000 2,665,000 2,522,000 5,789,000 -11,513,000 -54,420,000 64,776,000 -10,326,000 -6,194,000 98,000 -8,756,000 22,704,000 -16,572,000 -5,136,000 -30,467,000 -1,626,000 14,836,000 -3,592,000 24,953,000 1,835,000 -6,712,000 -7,553,000 22,512,000 1,004,000 10,677,000 -29,187,000 4,879,000 21,287,000 -25,428,000 27,515,000      3,400,000 8,661,000          -14,977,000   2,415,000   32,557,000    16,191,000 -9,396,000 17,985,000 
          cash and cash equivalents at end of period
        		    5,054,000 15,639,000 10,479,000 25,574,000 -12,628,000 -3,398,000 8,527,000 40,285,000 -5,407,000 2,665,000 2,522,000 24,679,000 -11,513,000 -54,420,000 64,776,000 20,047,000 -6,194,000 98,000 -8,756,000 45,225,000 -16,572,000 -5,136,000 -30,467,000 74,696,000 14,836,000 -3,592,000 24,953,000 40,125,000 -6,712,000 -7,553,000 40,144,000 1,004,000 10,677,000 14,269,000 4,879,000 21,287,000 -25,428,000 42,718,000 -11,068,000 8,972,000 14,910,000 -5,837,000 -165,000 22,033,000 8,661,000 -53,539,000 102,596,000 -27,654,000 23,257,000 43,166,000 -55,373,273 -6,807,000 -3,058,000 65,286,000 -14,977,000 81,432,000 -2,586,000 12,910,000 -2,197,000 -34,366,000 42,178,000 -34,025,000 36,659,000 21,433,000 16,191,000 -9,396,000 29,473,000 
          purchases of intangible asset included within accounts payable
        		                                                                       
          net proceeds from issuances of common stock upon exercise of options
        		     158,000 252,000 89,000    1,000    940,000    2,097,000               341,000                                     
          net loss
        		      -1,030,000 -8,247,000 737,000 -5,692,000 -6,600,000 -13,536,000         -19,237,000    -17,200,000 -11,490,000                                              
          adjustments to reconcile net loss to net cash from operating activities:
        		                                                                       
          intangible assets included within acquisition-related liabilities
        		      -222,000 15,222,000                                                                
          net amortization of discount on short-term investments and term loan
        		       -205,000                                                                
          prepaid and other current assets
        		       -2,584,000 -3,246,000 1,952,000 2,900,000 392,000 -2,102,000 1,782,000 1,476,000 -2,003,000 -1,480,000 674,000 1,665,000 5,774,000 -3,690,000 -3,173,000 1,942,000 338,000 -3,673,000 -1,817,000 680,000 -863,000 -1,917,000 -11,000 769,000 -638,000 58,000 -107,000 65,000 570,000 -83,000 766,000 -878,000 -437,000                                
          other assets
        		        -29,000 -14,000 1,000 98,000 -156,000 -81,000 61,000 510,000 -39,000 -95,000 -22,000 6,000 -4,000 -167,000 8,000 35,000 -1,000 18,000 16,000 6,000 -83,000 26,000 -408,000 533,000 36,000 27,000 33,000 42,000 42,000 46,000 107,000 -16,000 40,000 28,000 47,000 23,000 44,000 58,000 56,000 59,000 40,000 37,000 38,000 38,000 39,000 37,000 -126,835 32,000 70,000 25,000 42,000 32,000 38,000 43,000 30,000 5,000 26,000 55,000 96,000 27,000    
          net amortization and accretion of discount on short-term investments and term loan
        		        -260,000 -105,000 -46,000 -68,000 -179,000 9,000 79,000 28,000 116,000 76,000 10,000 85,000 49,000 36,000 -69,000 -138,000                                                
          purchases of intangible asset
        		        0 0 0 -15,000,000                                                            
          purchases of property and equipment
        		                                                                       
          net proceeds from issuances of common stock upon exercise of options and participation in purchase plan
        		        486,000 9,000   585,000 0   1,085,000 274,000   667,000 52,000 541,000 1,336,000              4,000                                  
          cost share advance from a collaboration partner
        		                                                                       
          net gain on sale and write-down of property and equipment
        		                                                                       
          gain on disposal of assets
        		             -212,000                   0 0 -732,000    0                                 
          proceeds from disposal of assets
        		             279,000                   0 0 732,000    0                                 
          cost share advance from collaboration partner
        		                0 0                                                      
          cost share payment to a collaboration partner
        		              -6,228,000 -2,118,000                                                        
          other long-term liabilities
        		                                                                       
          deferred rent and other long-term liabilities
        		                       -98,000                            929,000 837,000 963,000    81,000     1,401,000 1,492,000 1,416,000       
          proceeds from sale and issuance of common stock, net of offering costs
        		                            0 0   2,567,000 3,092,000 43,083,000 12,868,000                                    
          non-cash operating lease expense
        		                     2,038,000 1,864,000 1,934,000  1,763,000 1,727,000 1,691,000                                            
          loss on sublease
        		                                0 0 495,000                                     
          net amortization of discount on short-term investments
        		                         -304,000                                              
          net proceeds from issuances of common stock upon exercise of options and participation in employee stock purchase plan
        		                         10,000 856,000 16,000 1,099,000 635,000 987,000 2,011,000 770,000   314,000                                    
          net amortization of discount on short-term investment
        		                           -282,000                                            
          deferred rent and other long term liabilities
        		                            120,000 83,000 120,000 -645,000 -1,861,000 -1,763,000 -1,296,000 -1,343,000 -1,329,000 -1,266,000 -1,174,000                                 
          non-cash restructuring charges
        		                                                                       
          net amortization of premium (discount) on short-term investment
        		                                                                       
          net amortization of premium on short-term investment
        		                             -224,000 -183,000 -134,000 -91,000 -74,000 -33,000                                     
          stock-based compensation
        		                                                                       
          sales of short-term investments
        		                                                                       
          proceeds from issuance of common stock, net of offering costs
        		                                                                       
          net proceeds from issuances of common stock
        		                                       98,000 1,012,000 17,000 5,000 661,000 24,000 0 334,000 488,000 222,000 1,231,000 128,496,000 143,000 52,938,000 56,000  1,145,000    81,809,000 741,000 5,109,000      52,000 15,000 462,000 31,223,000 
          prepaid expenses and other current assets
        		                                         367,000    804,000      -97,000 314,000 13,000 -414,580 28,000 305,000 82,000           609,000   
          purchases of available-for-sale securities
        		                                                                       
          maturities of available-for-sale securities
        		                                          53,866,000 73,750,000 90,275,000 81,926,000   63,877,000 36,536,000 30,676,000 26,470,000 27,501,000 29,269,000 -55,358,013 26,280,000 19,718,000 9,450,000 18,333,000 27,734,000 23,655,000 19,505,000 17,185,000 14,150,000 10,250,000 -7,000   3,300,000 12,450,000 6,875,000 
          sales of available-for-sale securities
        		                                             0                          
          net decrease in cash and cash equivalents
        		                                                                       
          maturities and sales of available-for-sale securities
        		                                               133,685,000                        
          payments on capital lease obligations
        		                                                                       
          sale of available-for-sale securities
        		                                                                       
          proceeds from capital lease financings
        		                                                534,000 610,000 219,000 0 241,000 399,000                  
          schedule of non cash transactions
        		                                                                       
          issuance of warrant with lease amendment
        		                                                                       
          other receivables
        		                                                  143,000    -74,509     18,000            
          net increase/(decrease) in cash and cash equivalents
        		                                                  58,093,000                     
          amortization of deferred stock compensation
        		                                                          13,000 6,000 5,000 6,000 14,000 34,000 54,000 77,000 153,000 224,000 43,000 254,000 480,000 
          non-cash stock compensation expense
        		                                                      -10,124,421 3,449,000 3,127,000 3,561,000              
          issuances of equity instruments for noncash benefits
        		                                                                    6,000 5,000 4,000 
          loss on disposal/sale of property and equipment
        		                                                                       
          proceeds from the sale of property and equipment
        		                                                                 0 0 71,000    
          proceeds from capital lease financing
        		                                                        375,000 882,000 465,000 0 189,000 1,002,000    324,000 769,000 98,000 435,000 1,024,000 540,000 
          net proceeds from issuances of common stock and warrants
        		                                                         144,000     1,314,000 435,000 58,582,000 9,114,000      
          deferred stock compensation
        		                                                                       
          issuance of warrants with lease amendment
        		                                                                       
          non-cash stock compensation (recovery)/expense
        		                                                                       
          advance from landlord
        		                                                                 8,000 57,000 343,000    
          operating activities:
        		                                                                       
          non-cash stock compensation
        		                                                              2,262,000 -851,000 891,000       
          investing activities:
        		                                                                       
          purchase of available-for-sale securities
        		                                                                       
          net cash provided by/(used in) investing activities
        		                                                           13,658,000 7,855,000 2,864,000          
          financing activities:
        		                                                                       
          issuances of equity instruments for non-cash benefits
        		                                                              32,000 26,000 38,000 0      
          loss on sale of property and equipment
        		                                                                 0      
          prepaid expenses and other current assets, including receivable from landlord
        		                                                                 -97,000 230,000 6,043,000    
          proceeds from equipment financing
        		                                                                       
          non-cash stock compensation recovery
        		                                                                       
          accrued liabilities
        		                                                                    1,106,000 464,000 92,000 
          principal payments on capital lease obligations
        		                                                                       
          deferred rent
        		                                                                  1,445,000 892,000    
          loss on sale of assets
        		                                                                   169,000    
          noncash stock compensation recovery
        		                                                                       
          adjustments to reconcile net income to net cash used in
        		                                                                       
          noncash stock compensation
        		                                                                       
          net proceeds from issuances of convertible preferred stock
        		                                                                       
          net cash (used) provided by financing activities