7Baggers

REGENXBIO Inc
(NASDAQ:RGNX) 

RGNX stock logo

REGENXBIO Inc., a clinical-stage biotechnology company, provides gene therapy product candidates to deliver genes to cells to address genetic defects or to enable cells in the body to produce therapeutic proteins or antibodies that are intended to impact disease. Its gene therapy product candidates ...

Founded: 2008
Full Time Employees: 257
Sector: Healthcare
Industry: Biotechnology
Pharmaceuticals
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Quarterly
Annual
    Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 
                                               
      revenues
    		                                           
      license and royalty revenue
    		5,090,000 27,148,000 23,605,000 18,465,000 87,049,000 21,214,000 24,197,000 22,295,000 15,622,000 22,213,000 28,914,000 19,977,000 19,138,000 31,345,000 26,512,000 32,649,000 22,218,000 398,655,000 30,773,000 22,035,000 18,884,000 21,445,000 98,912,000 16,566,000 17,644,000 11,768,000 14,700,000 7,881,000                
      service revenue
    		1,303,000 3,189,000 6,128,000 2,894,000 1,963,000                                       
      total revenues
    		6,393,000 30,337,000 29,733,000 21,359,000 89,012,000 21,214,000 24,197,000 22,295,000 15,622,000 22,213,000 28,914,000 19,977,000 19,138,000 31,345,000 26,512,000 32,649,000 22,218,000 398,655,000 30,773,000 22,035,000 18,884,000 21,445,000 98,912,000 16,566,000 17,644,000 11,768,000 14,700,000 7,881,000 884,000 40,777,000 5,306,000 40,031,000 132,391,000 2,040,000 1,336,000 6,562,000 455,000 1,696,000 125,000 2,375,000 393,000 4,448,000 1,140,000 
      yoy
    		-92.82% 43.00% 22.88% -4.20% 469.79% -4.50% -16.31% 11.60% -18.37% -29.13% 9.06% -38.81% -13.86% -92.14% -13.85% 48.17% 17.66% 1758.96% -68.89% 33.01% 7.03% 82.23% 572.87% 110.20% 1895.93% -71.14% 177.04% -80.31% -99.33% 1898.87% 297.16% 510.04% 28996.92% 20.28% 968.80% 176.29% 15.78% -61.87% -89.04%     
      qoq
    		-78.93% 2.03% 39.21% -76.00% 319.59% -12.33% 8.53% 42.72% -29.67% -23.18% 44.74% 4.38% -38.94% 18.23% -18.80% 46.95% -94.43% 1195.47% 39.66% 16.69% -11.94% -78.32% 497.08% -6.11% 49.93% -19.95% 86.52% 791.52% -97.83% 668.51% -86.75% -69.76% 6389.75% 52.69% -79.64% 1342.20% -73.17% 1256.80% -94.74% 504.33% -91.16% 290.18%  
      operating expenses
    		                                           
      cost of license and royalty revenues
    		11,074,000 5,928,000 5,725,000 5,209,000 3,436,000                                       
      research and development
    		57,339,000 59,611,000 56,101,000 59,500,000 53,087,000 50,380,000 54,429,000 48,869,000 54,844,000 55,681,000 58,183,000 59,886,000 58,516,000 62,505,000 63,313,000 61,008,000 55,627,000 47,978,000 47,855,000 45,882,000 39,722,000 47,180,000 43,968,000 38,111,000 37,035,000 33,807,000 35,692,000 29,483,000 25,203,000 24,329,000 18,508,000 21,486,000 19,550,000 14,170,000 12,518,000 13,917,000 16,619,000 16,059,000 12,560,000 10,680,000 6,183,000 4,808,000 5,664,000 
      general and administrative
    		21,306,000 22,380,000 20,253,000 19,883,000 20,347,000 20,051,000 19,422,000 18,855,000 18,291,000 19,079,000 23,083,000 23,698,000 22,634,000 21,210,000 20,921,000 20,832,000 22,318,000 22,040,000 21,030,000 18,425,000 17,838,000 17,571,000 15,859,000 15,554,000 14,833,000 14,450,000 12,402,000 13,405,000 11,558,000 11,144,000 9,008,000 8,318,000 8,380,000 4,808,000 9,444,000 6,355,000 6,622,000 5,742,000 6,200,000 6,169,000 5,479,000 4,241,000 2,567,000 
      other operating expenses
    		36,000 54,000 65,000 45,000 15,000 833,000 37,000 29,000 -34,000 118,000 220,000 26,000 33,000           50,000 67,000 44,000 8,000 -62,000  11,000 -2,000 5,000 28,000 42,000  29,000 45,000 34,000 -2,000 -20,000 -114,000   
      total operating expenses
    		89,755,000 87,973,000 82,144,000 84,637,000 76,885,000 72,582,000 86,275,000 78,332,000 79,485,000 86,116,000 93,874,000 93,085,000 85,295,000 89,116,000 97,557,000 95,182,000 93,745,000 85,059,000 88,121,000 74,261,000 62,926,000 75,096,000 84,961,000 58,399,000 55,344,000 52,092,000 50,596,000 44,753,000 36,790,000 38,327,000 28,031,000 33,681,000 30,366,000 18,638,000 22,645,000 21,618,000 23,377,000 22,165,000 18,793,000 17,327,000 11,644,000 9,947,000 8,487,000 
      income from operations
    		-83,362,000 -57,636,000 -52,411,000 -63,278,000 12,127,000 -51,368,000 -62,078,000 -56,037,000 -63,863,000 -63,903,000 -64,960,000 -73,108,000 -66,157,000 -57,771,000 -71,045,000 -62,533,000 -71,527,000 313,596,000 -57,348,000 -52,226,000 -44,042,000 -53,651,000 13,951,000 -41,833,000 -37,700,000 -40,324,000 -35,896,000 -36,872,000 -35,906,000 2,450,000 -22,725,000 6,350,000 102,025,000 -16,598,000 -21,309,000 -15,056,000 -22,922,000 -20,469,000 -18,668,000 -14,952,000 -11,251,000 -5,499,000 -7,347,000 
      yoy
    		-787.41% 12.20% -15.57% 12.92% -118.99% -19.62% -4.44% -23.35% -3.47% 10.61% -8.56% 16.91% -7.51% -118.42% 23.88% 19.74% 62.41% -684.51% -511.07% 24.84% 16.82% 33.05% -138.87% 13.45% 5.00% -1745.88% 57.96% -680.66% -135.19% -114.76% 6.65% -142.18% -545.10% -18.91% 14.15% 0.70% 103.73% 272.23% 154.09%     
      qoq
    		44.64% 9.97% -17.17% -621.79% -123.61% -17.25% 10.78% -12.25% -0.06% -1.63% -11.15% 10.51% 14.52% -18.68% 13.61% -12.57% -122.81% -646.83% 9.81% 18.58% -17.91% -484.57% -133.35% 10.96% -6.51% 12.34% -2.65% 2.69% -1565.55% -110.78% -457.87% -93.78% -714.68% -22.11% 41.53% -34.32% 11.98% 9.65% 24.85% 32.89% 104.60% -25.15%  
      operating margin %
    		-1303.96% -189.99% -176.27% -296.26% 13.62% -242.14% -256.55% -251.34% -408.80% -287.68% -224.67% -365.96% -345.68% -184.31% -267.97% -191.53% -321.93% 78.66% -186.36% -237.01% -233.22% -250.18% 14.10% -252.52% -213.67% -342.66% -244.19% -467.86% -4061.76% 6.01% -428.29% 15.86% 77.06% -813.63% -1594.99% -229.44% -5037.80% -1206.90% -14934.40% -629.56% -2862.85% -123.63% -644.47% 
      other income
    		                                           
      interest income from licensing
    		16,000 18,000 19,000 21,000 25,000 83,000 25,000 29,000 37,000 -141,000 56,000 40,000 70,000 77,000 18,000 153,000 94,000 19,000 117,000 554,000 29,000 130,000 1,444,000 1,849,000 848,000 860,000 716,000 762,000 613,000 584,000 109,000 6,898,000 1,355,000           
      investment income
    		2,003,000 2,745,000 3,620,000 3,379,000 2,501,000 9,516,000 3,276,000 3,468,000 2,469,000 2,366,000 4,660,000 2,127,000 2,166,000 2,026,000 1,497,000 1,061,000 799,000 311,000 5,535,000 399,000 580,000 13,794,000 -6,607,000 5,722,000 -3,186,000 10,609,000 431,000 34,524,000 2,995,000 2,893,000 2,122,000 1,196,000 859,000 601,000 603,000 583,000 929,000 426,000 514,000 515,000 483,000 323,000 15,000 
      interest expense
    		-8,708,000 -12,276,000 -13,169,000 -10,993,000 -8,570,000 -9,417,000 -820,000 -449,000 -1,973,000 -1,363,000 -1,624,000 -1,120,000 -2,755,000 -4,310,000 -5,954,000 -6,860,000 -6,130,000 -6,500,000 -6,709,000 -6,366,000 -6,702,000                       
      total other income
    		-6,689,000 -9,513,000 -9,530,000 -7,593,000 -6,044,000 182,000 2,481,000 3,048,000 533,000 862,000 3,092,000 1,047,000 -519,000 -2,207,000 -4,439,000 -5,646,000 -5,237,000 -6,170,000 -1,057,000 -5,413,000 -6,093,000 13,153,000 -5,163,000 7,571,000 -2,338,000 11,469,000 1,147,000 35,286,000 3,608,000 3,477,000 2,231,000 8,094,000 2,214,000 601,000 603,000 583,000 929,000 426,000 514,000 515,000 483,000 323,000 15,000 
      net income
    		-90,051,000 -67,149,000 -61,941,000 -70,871,000 6,083,000 -51,186,000 -59,597,000 -52,989,000 -63,330,000 -62,889,000 -61,868,000 -72,061,000 -66,676,000 -59,935,000 -75,484,000 -68,179,000 -76,723,000 294,023,000 -58,405,000 -57,639,000 -50,139,000 -46,241,000 8,791,000 -33,762,000 -40,038,000 -26,464,000 -34,584,000 -1,457,000 -32,228,000 4,306,000 -19,202,000 10,594,000 104,239,000 -15,997,000 -20,706,000 -14,473,000 -21,993,000 -19,608,000 -18,154,000 -14,437,000 -10,768,000 -5,176,000 -7,332,000 
      yoy
    		-1580.37% 31.19% 3.93% 33.75% -109.61% -18.61% -3.67% -26.47% -5.02% 4.93% -18.04% 5.69% -13.10% -120.38% 29.24% 18.29% 53.02% -735.85% -764.37% 70.72% 25.23% 74.73% -125.42% 2217.23% 24.23% -714.58% 80.11% -113.75% -130.92% -126.92% -7.26% -173.20% -573.96% -18.42% 14.06% 0.25% 104.24% 278.83% 147.60%     
      qoq
    		34.11% 8.41% -12.60% -1265.07% -111.88% -14.11% 12.47% -16.33% 0.70% 1.65% -14.14% 8.08% 11.25% -20.60% 10.71% -11.14% -126.09% -603.42% 1.33% 14.96% 8.43% -626.00% -126.04% -15.68% 51.29% -23.48% 2273.64% -95.48% -848.44% -122.42% -281.25% -89.84% -751.62% -22.74% 43.07% -34.19% 12.16% 8.01% 25.75% 34.07% 108.04% -29.41%  
      net income margin %
    		-1408.59% -221.34% -208.32% -331.81% 6.83% -241.28% -246.30% -237.67% -405.39% -283.12% -213.97% -360.72% -348.40% -191.21% -284.72% -208.82% -345.32% 73.75% -189.79% -261.58% -265.51% -215.63% 8.89% -203.80% -226.92% -224.88% -235.27% -18.49% -3645.70% 10.56% -361.89% 26.46% 78.74% -784.17% -1549.85% -220.56% -4833.63% -1156.13% -14523.20% -607.87% -2739.95% -116.37% -643.16% 
      other comprehensive loss
    		                                           
      unrealized loss on available-for-sale securities
    		-183,000             2,855,000 -3,493,000  -9,381,000    -1,008,000                     -693,000 -26,000 
      total other comprehensive loss
    		-183,000             2,855,000 -3,493,000  -9,381,000    -1,008,000            -188,000         -693,000 -26,000 
      comprehensive income
    		-90,234,000    6,062,000             292,739,000 -58,435,000   -46,864,000 8,304,000   -26,622,000 -34,692,000 -927,000 -31,607,000 4,460,000 -19,305,000 10,726,000 104,051,000           
      net income per share
    		 -1.3 -1.2 -1.38  -1 -1.17 -1.05 -1.38 -1.15 -1.41 -1.66 -1.53 -1.278 -1.75 -1.58 -1.79   -1.36 -1.2                       
      basic
    		-1.72    0.12             6.94 -1.37   -1.23 0.24   -0.72 -0.94 -0.04 -0.89 0.05 -0.56 0.33 3.3           
      diluted
    		-1.72    0.12             6.84 -1.37   -1.23 0.23   -0.72 -0.94 -0.04 -0.89 0.06 -0.56 0.3 3.04           
      weighted-average common shares outstanding:
    		                                           
      basic
    		52,428    51,362     43,734    43,152    42,438 42,629   37,281 37,342   36,690 36,813 36,669 36,366 33,427 33,988 32,082 31,632           
      diluted
    		52,428    51,434     43,734    43,152    43,913 42,629   37,281 38,877   36,690 36,813 36,669 36,366 36,648 33,988 35,272 34,275           
      impairment of long-lived assets
    		        2,101,000                                   
      other comprehensive income
    		                                           
      unrealized gain on available-for-sale securities
    		 -35,000 98,000 12,000 -21,000 -159,000 1,684,000 963,000 1,200,000 2,984,000 2,685,000 1,524,000 3,779,000   -2,813,000  -1,284,000 -30,000 113,000  -623,000 -487,000 1,330,000 -785,000             393,000 332,000 246,000 994,000   
      total other comprehensive income
    		 -35,000 98,000 12,000 -21,000 -159,000 1,684,000 963,000 1,200,000 2,984,000 2,685,000 1,524,000 3,779,000   -2,813,000  -1,284,000 -30,000 113,000  -623,000 -487,000 1,330,000 -785,000 -158,000 -108,000 530,000 621,000 154,000 -103,000 132,000  -161,000 93,000 -74,000 -539,000 -886,000 332,000 246,000 994,000   
      comprehensive loss
    		 -67,184,000 -61,843,000 -70,859,000  -51,345,000 -57,913,000 -52,026,000 -62,130,000 -48,154,250 -59,183,000 -70,537,000 -62,897,000 -59,018,250 -78,977,000 -70,992,000 -86,104,000   -57,526,000 -51,147,000   -32,432,000 -40,823,000         -16,158,000 -20,613,000 -14,547,000 -22,532,000 -20,494,000 -17,822,000 -14,191,000 -9,774,000 -5,869,000 -7,358,000 
      net income per share
    		 -1.3 -1.2 -1.38  -1 -1.17 -1.05 -1.38 -1.15 -1.41 -1.66 -1.53 -1.278 -1.75 -1.58 -1.79   -1.36 -1.2                       
      weighted-average common shares outstanding, basic and diluted
    		 51,573 51,689 51,483  49,509 50,800 50,601 45,733  43,945 43,531 43,451  43,251 43,111 42,944   42,510 41,819                       
      cost of revenues
    		     6,318,000 12,387,000 10,579,000 4,283,000 11,238,000 12,388,000 9,475,000 4,112,000 12,783,000 13,094,000 12,951,000 15,717,000 23,058,000 14,105,000 9,819,000 4,851,000 10,257,000 17,364,000 4,684,000 3,409,000 3,791,000 2,494,000 1,927,000                
      income before income taxes
    		         -63,041,000 -61,868,000 -72,061,000 -66,676,000 -59,978,000 -75,484,000 -68,179,000 -76,764,000 307,426,000 -58,405,000 -57,639,000 -50,135,000 -40,498,000 8,788,000 -34,262,000 -40,038,000 -28,855,000 -34,749,000 -1,586,000 -32,298,000 5,927,000 -20,494,000 14,444,000            
      income tax benefit
    		             43,000   41,000 -13,403,000    -5,743,000 3,000 500,000  2,391,000 165,000 129,000 70,000 -1,621,000 1,292,000             
      credit losses and other
    		             175,750 229,000 391,000 83,000                           
      provision for credit losses and other
    		                 1,445,250 5,131,000 135,000 515,000 88,000 7,770,000                     
      income tax expense
    		                    -4,000           -3,850,000            
      basic and diluted net loss per share
    		                       -0.91 -1.08                   
      weighted-average basic and diluted common shares outstanding
    		                       37,257 37,104                   
      unrealized gain on available-for-sale securities, net of reclassifications and income tax expense
    		                         260,750 -108,000 530,000 621,000 154,000 -103,000 132,000            
      net income applicable to common stockholders
    		                         -26,464,000 -34,584,000 -1,457,000 -32,228,000 4,306,000 -19,202,000 10,594,000 104,239,000           
      license revenue
    		                            884,000 40,777,000 5,306,000 40,031,000 132,391,000 2,040,000 1,335,000 6,555,000 455,000 1,665,000 65,000 2,245,000 328,000 4,390,000 65,000 
      costs of revenues
    		                                           
      licensing costs
    		                            29,000 2,843,000 517,000 3,872,000 2,408,000 -382,000 683,000 1,311,000 91,000 333,000 13,000 449,000 66,000   
      other revenues
    		                                           
      expenses
    		                                           
      other
    		                                           
      unrealized loss on available-for-sale securities, net of reclassifications and income tax expense
    		                                -188,000           
      reagent sales
    		                                      47,000 107,000 59,000 57,000 61,000 
      grant revenue
    		                                  1,000 7,000  31,000 13,000 23,000 6,000 1,000 14,000 
      costs of reagent sales
    		                                   6,000  -3,000 22,000 49,000 30,000 4,000 44,000 
      unrealized gain on available-for-sale securities, net of reclassifications of 479 and 20 for the nine months ended september 30, 2017 and 2016, respectively
    		                                 -130,250 93,000         
      net loss applicable to common stockholders
    		                                 -15,997,000 -20,706,000 -14,473,000 -21,993,000 -19,608,000 -18,154,000 -14,437,000 -10,768,000 -5,176,000 -7,332,000 
      basic and diluted net loss per common share
    		                                 -510 -670 -470 -820 -740 -690 -550 -410 2,890 -1,520 
      weighted-average basic and diluted common shares
    		                                 29,878,000 30,940,000 30,662,000 26,673,000 26,409,000 26,469,000 26,362,000 26,327,000 9,173,000 4,809,000 
      unrealized gain on available-for-sale securities, net of reclassifications of 480 for the six months ended june 30, 2017
    		                                   -74,000        
      unrealized gain on available-for-sale securities, net of reclassifications of 480 for the three months ended march 31, 2017
    		                                    -539,000       
      license revenue from related party
    		                                          1,000,000 
      reconciliation of net loss to net loss applicable to common stockholders
    		                                           
      net accretion and dividends on convertible preferred stock
    		                                           
      net gain on extinguishment of convertible preferred stock
    		                                           
      net decretion and dividends on convertible preferred stock
    		                                           
      licensing costs to related parties
    		                                         131,750 213,000 
      foreign currency transaction losses
    		                                         16,000 4,000 
      other operating income
    		                                          -5,000 
      accretion and dividends on convertible preferred stock
    		                                           
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 
                                                 
        assets
      		                                           
        current assets
      		                                           
        cash and cash equivalents
      		15,229,000 34,466,000 58,802,000 79,558,000 130,104,000 57,526,000 56,617,000 57,765,000 112,975,000 34,522,000 53,045,000 68,600,000 70,091,000 96,952,000 118,544,000 121,374,000 191,873,000 345,209,000 228,387,000 257,072,000 291,482,000 338,426,000 93,220,000 94,222,000 69,411,000 69,514,000 79,594,000 55,142,000 55,852,000 75,561,000 142,423,000 106,889,000 71,870,000 46,656,000 59,884,000 57,649,000 82,045,000 24,840,000 28,108,000 30,083,000 35,511,000 54,116,000 205,324,000 
        marketable securities
      		135,262,000 195,604,000 215,403,000 243,740,000 137,765,000 177,161,000 198,843,000 232,592,000 225,728,000 240,736,000 248,842,000 251,482,000 261,726,000 267,690,000 263,874,000 281,588,000 202,261,000 112,230,000 111,473,000 117,665,000 149,398,000 137,314,000 148,305,000 174,964,000 209,846,000 226,696,000 252,125,000 286,354,000 229,373,000 244,200,000 230,166,000 179,605,000 157,997,000 114,122,000 106,778,000 104,434,000 63,764,000 64,714,000 63,662,000 64,124,000 65,544,000 60,025,000 8,025,000 
        accounts receivable
      		10,038,000 26,379,000 25,347,000 20,199,000 18,192,000 20,473,000 23,604,000 22,809,000 15,828,000 24,790,000 28,043,000 21,380,000 18,861,000 28,082,000 32,549,000 37,500,000 27,022,000 32,439,000 46,017,000 44,394,000 41,039,000 42,999,000 122,116,000 42,876,000 44,522,000 38,148,000 19,175,000 9,679,000 8,372,000 8,587,000 2,626,000 739,000 25,976,000 473,000 884,000 50,000 228,000 1,032,000 679,000 783,000 2,036,000   
        prepaid expenses
      		11,543,000 11,927,000 12,943,000 10,776,000 11,094,000 9,067,000 11,002,000 10,021,000 13,590,000 14,520,000 12,561,000 15,112,000 15,521,000 13,900,000 14,824,000 16,245,000 18,542,000 18,752,000 18,401,000 13,092,000 13,839,000 10,505,000 16,112,000 9,749,000 7,422,000 6,475,000 6,920,000 6,036,000 6,292,000 5,734,000 6,308,000 3,690,000 4,667,000 5,334,000 3,225,000 2,432,000 1,843,000 1,775,000 2,171,000 1,480,000 1,189,000 1,020,000 1,400,000 
        other current assets
      		14,444,000 12,905,000 19,472,000 19,479,000 16,082,000 13,774,000 23,330,000 23,496,000 27,297,000 20,403,000 23,347,000 22,235,000 23,003,000 9,352,000 6,848,000 8,717,000 7,179,000 10,196,000 5,886,000 5,164,000 2,880,000 1,953,000 7,197,000 7,271,000 7,032,000 4,199,000 2,414,000 2,281,000 3,995,000 3,831,000 4,834,000 2,347,000 2,208,000 1,412,000 1,390,000 1,252,000 922,000 1,010,000 2,000,000 1,437,000 1,300,000 851,000 127,000 
        total current assets
      		186,516,000 281,281,000 331,967,000 373,752,000 313,237,000 278,001,000 313,396,000 346,683,000 395,418,000 334,971,000 365,838,000 378,809,000 389,202,000 415,976,000 436,639,000 465,424,000 446,877,000 518,826,000 410,164,000 437,387,000 498,638,000 531,197,000 386,950,000 329,082,000 338,233,000 345,032,000 360,228,000 359,492,000 303,884,000 337,913,000 386,357,000 293,270,000 262,718,000 167,997,000 172,161,000 165,817,000 148,802,000 93,371,000 96,620,000 97,907,000 105,580,000 118,148,000 215,485,000 
        property and equipment
      		101,874,000 104,855,000 107,515,000 111,017,000 114,497,000 117,589,000 120,551,000 123,969,000 127,662,000 132,103,000 135,534,000 138,680,000 141,573,000 141,685,000 140,906,000 138,815,000 135,264,000 131,547,000 122,231,000 106,685,000 89,342,000 56,467,000 38,871,000 32,696,000 30,414,000 28,973,000 28,287,000 27,330,000 23,140,000 28,702,000 19,856,000 16,698,000 14,829,000 13,977,000 11,548,000 11,524,000 11,061,000 9,324,000 5,804,000 2,864,000 1,328,000 538,000 385,000 
        operating lease right-of-use assets
      		45,541,000 47,156,000 48,820,000 50,469,000 52,112,000 53,716,000 55,293,000 56,344,000 57,558,000 60,487,000 61,773,000 62,436,000 63,726,000 65,116,000 59,471,000 60,163,000 59,925,000 60,904,000 61,742,000 62,280,000 62,607,000 63,815,000 57,827,000 8,635,000 9,375,000 10,078,000 5,905,000 5,904,000 6,858,000               
        restricted cash
      		2,030,000 2,030,000 2,030,000 2,030,000 2,030,000 2,030,000 2,030,000 2,030,000 2,030,000 2,030,000 2,255,000 2,255,000 2,030,000 2,030,000 2,030,000 2,030,000 2,030,000 2,030,000 1,330,000 1,330,000 1,330,000 1,330,000 1,330,000 1,330,000 1,330,000 1,330,000 1,053,000 1,053,000 1,053,000 1,053,000 225,000 225,000 225,000 225,000 225,000 225,000 225,000 225,000 225,000 225,000    
        other assets
      		5,513,000 4,613,000 4,268,000 1,879,000 2,987,000 4,000,000 4,332,000 2,946,000 4,217,000 4,807,000 4,669,000 3,833,000 8,290,000 6,397,000 8,350,000 5,905,000 8,529,000 6,428,000 8,558,000 7,692,000 9,068,000 5,279,000 4,360,000 4,323,000 2,850,000 4,555,000 4,011,000 3,211,000 2,255,000 2,315,000 1,650,000 1,514,000 883,000 862,000 836,000 393,000 297,000 400,000 239,000 266,000 223,000 168,000 128,000 
        total assets
      		341,894,000 453,032,000 525,203,000 581,027,000 490,929,000 465,989,000 519,114,000 569,379,000 629,215,000 573,970,000 633,786,000 682,458,000 747,830,000 833,268,000 883,793,000 953,444,000 1,025,368,000 1,113,904,000 800,395,000 836,402,000 879,442,000 708,164,000 541,174,000 449,738,000 463,936,000 497,908,000 509,237,000 529,139,000 519,031,000 543,814,000 514,984,000 335,987,000 317,217,000 198,677,000 209,255,000 224,376,000 224,127,000 172,732,000 195,975,000 206,072,000 214,984,000 221,380,000 227,314,000 
        liabilities and stockholders’ equity
      		                                           
        current liabilities
      		                                           
        accounts payable
      		21,207,000 21,358,000 22,266,000 21,655,000 19,044,000 22,798,000 19,522,000 16,362,000 31,356,000 22,786,000 21,859,000 11,639,000 23,283,000 27,213,000 25,210,000 16,985,000 24,708,000 11,387,000 19,845,000 9,354,000 11,311,000 10,622,000 15,244,000 10,901,000 9,008,000 6,409,000 9,608,000 5,851,000 4,204,000 4,412,000 5,214,000 4,230,000 5,007,000 4,832,000 2,594,000 3,948,000 4,129,000 1,543,000 5,376,000 2,076,000 1,113,000 1,014,000 3,105,000 
        accrued expenses and other current liabilities
      		21,892,000 38,390,000 38,316,000 35,557,000 23,597,000 38,070,000 48,642,000 42,488,000 33,129,000 49,703,000 45,656,000 50,517,000 31,709,000 46,794,000 44,462,000 47,014,000 48,423,000 76,111,000 49,694,000 46,761,000 41,605,000 49,082,000 44,356,000 25,839,000 20,327,000 24,846,000 19,231,000 16,534,000 14,189,000 17,164,000 13,306,000 12,023,000 9,869,000 9,605,000 10,805,000 7,514,000 5,829,000 8,126,000 9,006,000 7,073,000 4,633,000 3,198,000  
        deferred revenue
      		5,919,000 10,452,000 13,195,000 13,977,000 13,588,000 115,000 144,000 21,000 13,000 148,000 442,000 448,000 1,311,000 1,829,000 5,903,000 6,636,000 3,333,000 3,333,000 395,000 395,000 395,000 449,000 449,000 450,000 3,333,000    600,000 600,000 600,000 600,000            
        operating lease liabilities
      		7,867,000 8,286,000 9,073,000 8,049,000 7,942,000 7,902,000 7,720,000 7,302,000 7,066,000 7,068,000 6,639,000 6,326,000 6,303,000 5,997,000 3,608,000 2,832,000 2,121,000 1,752,000 1,329,000 1,709,000 1,843,000 2,500,000 3,564,000 3,013,000 2,454,000 2,421,000 2,506,000 2,276,000 2,397,000               
        royalty monetization liabilities
      		14,225,000 39,609,000 41,718,000 40,302,000                                        
        total current liabilities
      		71,110,000 118,095,000 124,568,000 119,540,000 106,731,000 103,194,000 102,725,000 98,273,000 110,179,000 130,272,000 127,346,000 117,893,000 112,334,000 130,434,000 123,548,000 114,556,000 119,937,000 130,472,000 106,771,000 91,554,000 83,961,000 81,447,000 63,613,000 40,203,000 31,789,000 33,676,000 31,345,000 24,661,000 21,390,000 22,176,000 19,120,000 16,853,000 14,876,000 14,437,000 13,399,000 11,462,000 9,958,000 9,669,000 14,382,000 9,149,000 5,781,000 4,339,000 5,308,000 
        other liabilities
      		622,000 638,000 648,000 664,000 680,000 3,635,000 3,579,000 3,526,000 3,485,000 6,249,000 6,186,000 6,079,000 5,983,000 8,832,000 8,664,000 8,526,000 7,680,000 745,000 484,000 514,000 448,000 524,000 545,000 582,000 672,000 1,828,000 1,844,000 1,899,000 1,772,000 2,505,000 691,000 720,000 1,776,000           
        total liabilities
      		320,812,000 350,299,000 363,751,000 367,348,000 216,732,000 206,338,000 217,698,000 221,112,000 238,549,000 262,228,000 270,686,000 276,603,000 282,691,000 317,073,000 319,969,000 322,925,000 335,699,000 349,606,000 338,981,000 329,157,000 324,938,000 330,411,000 125,514,000 51,877,000 43,784,000 47,711,000 40,842,000 34,547,000 31,978,000 34,966,000 20,927,000 18,765,000 17,877,000 15,648,000 14,604,000 12,679,000 11,229,000 10,995,000 15,749,000 9,897,000 6,383,000 4,572,000 5,506,000 
        stockholders’ equity
      		                                           
        preferred stock; 0.0001 par value...
      		                                           
        common stock; 0.0001 par value...
      		5,000 5,000 5,000 5,000 5,000 5,000 5,000 5,000 5,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 
        additional paid-in capital
      		1,238,025,000 1,229,442,000 1,220,977,000 1,211,361,000 1,201,020,000 1,192,536,000 1,182,956,000 1,171,894,000 1,162,267,000 1,021,214,000 1,012,667,000 996,239,000 984,986,000 973,145,000 963,694,000 951,412,000 939,570,000 928,095,000 917,950,000 905,346,000 895,079,000 667,181,000 658,224,000 648,729,000 638,588,000 627,810,000 619,386,000 610,891,000 602,425,000 592,580,000 582,249,000 386,110,000 378,954,000 371,497,000 366,960,000 363,393,000 350,047,000 276,354,000 274,349,000 272,476,000 270,711,000 269,144,000 268,275,000 
        accumulated other comprehensive loss
      		-870,000 -687,000 -652,000 -750,000 -762,000 -741,000 -582,000 -2,266,000 -3,229,000 -4,429,000 -7,413,000 -10,098,000 -11,622,000 -15,401,000 -18,256,000 -14,763,000 -11,950,000 -2,569,000 -1,285,000 -1,255,000 -1,368,000        -59,000 -720,000 -874,000 -771,000 -903,000 -715,000 -553,000 -646,000 -572,000 -33,000    -719,000 -26,000 
        accumulated deficit
      		-1,216,078,000 -1,126,027,000 -1,058,878,000 -996,937,000 -926,066,000 -932,149,000 -880,963,000 -821,366,000 -768,377,000 -705,047,000 -642,158,000 -580,290,000 -508,229,000 -441,553,000 -381,618,000 -306,134,000 -237,955,000 -161,232,000 -455,255,000 -396,850,000 -339,211,000 -289,072,000 -242,831,000 -251,622,000 -217,860,000 -177,822,000 -151,358,000 -116,774,000 -115,317,000 -83,016,000 -87,322,000 -68,120,000 -78,714,000 -187,756,000 -171,759,000 -151,053,000 -136,580,000 -114,587,000 -94,979,000 -76,825,000 -62,388,000 -51,620,000 -46,444,000 
        total stockholders’ equity
      		21,082,000 102,733,000 161,452,000 213,679,000 274,197,000 259,651,000 301,416,000 348,267,000 390,666,000 311,742,000 363,100,000 405,855,000 465,139,000 516,195,000 563,824,000 630,519,000 689,669,000 764,298,000 461,414,000 507,245,000 554,504,000 377,753,000 415,660,000 397,861,000 420,152,000 450,197,000 468,395,000 494,592,000 487,053,000 508,848,000 494,057,000 317,222,000 299,340,000 183,029,000 194,651,000 211,697,000 212,898,000 161,737,000 180,226,000 196,175,000 208,601,000 216,808,000 221,808,000 
        total liabilities and stockholders’ equity
      		341,894,000 453,032,000 525,203,000 581,027,000 490,929,000 465,989,000 519,114,000 569,379,000 629,215,000 573,970,000 633,786,000 682,458,000 747,830,000 833,268,000 883,793,000 953,444,000 1,025,368,000 1,113,904,000 800,395,000 836,402,000 879,442,000 708,164,000 541,174,000 449,738,000 463,936,000 497,908,000 509,237,000 529,139,000 519,031,000 543,814,000 514,984,000 335,987,000 317,217,000 198,677,000 209,255,000 224,376,000 224,127,000 172,732,000 195,975,000 206,072,000 214,984,000   
        commitments and contingencies
      		                                           
        liability related to sale of future royalties
      		    42,560,000 34,309,000 26,697,000 32,100,000 38,615,000 50,567,000 52,750,000 48,963,000 49,728,000 48,601,000 44,365,000 41,089,000 41,352,000 37,889,000 35,508,000 33,335,000 28,807,000 18,794,000                      
        accumulated other comprehensive income
      		                     -360,000 263,000 750,000 -580,000 205,000 363,000 471,000           853,000 521,000 275,000   
        deferred rent
      		                                          198,000 
        financing lease obligations
      		                                           
        deferred rent, net of current portion
      		                             1,098,000 1,116,000 1,192,000 1,225,000 1,211,000 1,205,000 1,217,000 1,271,000 1,326,000 1,367,000 748,000 602,000 233,000  
        financing lease obligation
      		                             5,854,000              
        cost method investments
      		                                       300,000 300,000 300,000 303,000 
        advance payments
      		                                        35,000 127,000 127,000 
        trade receivables
      		                                         2,136,000 609,000 
        related party receivables
      		                                           
        unbilled receivables
      		                                           
        deferred issuance costs
      		                                           
        liabilities, convertible preferred stock and stockholders’ equity
      		                                           
        due to related party under services agreement
      		                                           
        related party promissory notes
      		                                           
        other related party payables
      		                                          349,000 
        convertible preferred stock
      		                                           
        series a convertible preferred stock; 0.0001 par value...
      		                                           
        series b convertible preferred stock; 0.0001 par value...
      		                                           
        total convertible preferred stock
      		                                           
        total liabilities, convertible preferred stock and stockholders’ equity
      		                                         221,380,000 227,314,000 
        accrued expenses
      		                                          1,727,000 
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 
                                                  
          cash flows from operating activities
        		                                          
          net income
        		-90,051,000    6,083,000                     -26,464,000 -34,584,000 -1,457,000 -32,228,000 4,306,000 -19,202,000 10,594,000 104,239,000          
          adjustments to reconcile net income to net cash from operating activities
        		                                          
          stock-based compensation expense
        		8,617,000 8,375,000 8,998,000 8,653,000 8,537,000 9,542,000 9,884,000 9,435,000 9,602,000 8,338,000 10,219,000 10,504,000 11,206,000 9,408,000 10,245,000 10,335,000 10,800,000 9,162,000 9,734,000 9,992,000 9,920,000 7,581,000 8,035,000 8,316,000 8,017,000 6,875,000 7,162,000 7,099,000 5,718,000 4,886,000 4,483,000 3,981,000 3,291,000 2,796,000 2,735,000 2,483,000 2,591,000 2,000,000 1,829,000 1,656,000 1,546,000 862,000 
          depreciation and amortization
        		3,857,000 3,869,000 3,886,000 3,905,000 3,955,000 4,023,000 3,961,000 4,051,000 4,180,000 4,335,000 4,372,000 4,435,000 4,178,000 4,126,000 3,549,000 2,643,000 2,591,000 2,606,000 2,828,000 2,201,000 1,929,000 2,105,000 2,176,000 2,132,000 1,994,000 1,923,000 1,866,000 1,749,000 1,614,000 1,311,000 941,000 896,000 834,000 723,000 706,000 703,000 554,000 280,000 160,000 56,000 48,000 37,000 
          net accretion of discounts on marketable debt securities
        		-879,000 -1,229,000 -1,823,000 -1,356,000 -1,071,000                                      
          non-cash interest expense
        		3,753,000 5,106,000 5,305,000 2,767,000 -277,000 5,689,000 439,000 -715,000 688,000 155,000 667,000 -662,000 -574,000 -630,000 -107,000 820,000 54,000 -15,135,000 6,709,000 6,366,000 6,702,000                      
          other non-cash adjustments
        		19,000 537,000 48,000 22,000 -10,000 1,384,000 11,000 0 -71,000 154,000 220,000 -3,000 -52,000 33,000 232,000 351,000 -43,000 130,000 166,000 -63,000 -154,000 -100,000 -110,000 348,000 25,000 -89,000 -85,000 115,000 327,000 2,000 -1,000 3,000 10,000 34,000 -1,000 -1,000 41,000      
          changes in operating assets and liabilities
        		                                          
          accounts receivable
        		18,249,000 -561,000 -6,310,000 -2,362,000 1,572,000 8,133,000 -710,000 -6,893,000 9,177,000 3,369,000 -6,542,000 -2,387,000 9,495,000 4,844,000 5,006,000 -10,717,000 5,689,000 22,004,000 -6,402,000 -3,102,000 1,618,000 79,544,000 -86,731,000 3,033,000 -5,744,000 2,077,000 -9,280,000 -2,010,000 591,000 -23,789,000 -1,893,000 60,293,000 -51,414,000 411,000 -832,000 179,000 803,000 -386,000 106,000 1,240,000 113,000  
          prepaid expenses
        		384,000 1,016,000 -2,167,000 318,000 -2,027,000 1,935,000 -981,000 3,569,000 930,000 -1,959,000 2,551,000 409,000 -1,621,000 924,000 1,421,000 2,297,000 210,000 -351,000 -5,309,000 747,000 -3,334,000 5,607,000 -6,363,000 -2,327,000 -947,000 445,000 -884,000 256,000 -790,000 574,000 -2,618,000 977,000 667,000 -2,109,000 -793,000 -589,000 -68,000 396,000 -691,000 -291,000 -169,000 380,000 
          other current assets
        		-1,314,000 6,244,000 7,000 -3,353,000 -2,240,000 9,315,000 166,000 3,856,000 -6,826,000 3,027,000 -727,000 805,000 -13,651,000 -2,504,000 1,316,000 -1,607,000 3,042,000 -4,007,000 -200,000 -2,234,000 -873,000 5,339,000 74,000 -239,000 -2,833,000 -1,785,000 -133,000 1,714,000 -295,000 1,003,000 -2,487,000 -139,000 -446,000 -22,000 -138,000 -330,000 88,000 990,000 -563,000 -137,000 -449,000 -724,000 
          operating lease right-of-use assets
        		1,705,000 1,664,000 1,683,000 1,668,000 1,638,000 1,610,000 1,575,000 1,483,000 1,528,000 1,516,000 1,439,000 1,416,000 1,390,000 1,367,000 1,066,000 1,038,000 979,000 1,086,000 1,298,000 1,250,000 1,232,000 1,233,000 543,000 740,000 703,000 719,000 556,000 583,000 573,000              
          other assets
        		-900,000 -345,000 -2,389,000 1,108,000 1,013,000 332,000 -1,386,000 1,271,000 590,000 -138,000 -836,000 4,457,000 -1,893,000 1,953,000 -2,445,000 2,624,000 -2,101,000 2,130,000 -1,989,000 1,376,000 -3,789,000 -919,000 -37,000 -350,000 1,705,000 -544,000 -800,000 -1,376,000 26,000 -665,000 -136,000 -631,000 -21,000 -26,000 -23,000 -96,000 10,000 -68,000 27,000 -43,000 -55,000 -40,000 
          accounts payable
        		349,000 -1,861,000 694,000 2,534,000 -3,651,000 3,038,000 3,124,000 -14,915,000 8,461,000 1,220,000 10,097,000 -11,005,000 -3,103,000 1,907,000 7,356,000 -7,228,000 16,755,000 -8,807,000 7,350,000 -1,125,000 278,000 -6,034,000 5,829,000 1,015,000 3,063,000 -3,811,000 3,565,000 1,458,000 316,000 -374,000 496,000 -817,000 477,000 1,479,000 -1,581,000 255,000 2,468,000 -3,409,000 2,665,000 1,112,000 -182,000 273,000 
          accrued expenses and other current liabilities
        		-16,734,000 45,000 2,751,000 11,922,000 -14,489,000 -10,676,000 6,103,000 9,526,000 -17,077,000 3,998,000 -5,047,000 18,944,000 -15,443,000 2,625,000 -2,648,000 880,000 -26,473,000 29,435,000 6,353,000 4,664,000 -10,544,000 -1,000,000 16,966,000 5,247,000 -3,813,000 4,892,000 2,947,000 1,975,000 -2,932,000 4,144,000 872,000 2,076,000 490,000 -1,552,000 3,480,000 1,889,000 -1,920,000 -718,000 1,609,000 1,772,000 1,210,000  
          deferred revenue
        		-700,000 -4,986,000 -3,400,000 -2,104,000 39,770,000 -29,000 123,000 8,000 -135,000 -294,000 -6,000 -779,000 -433,000 -3,989,000 -648,000           0 0   3,333,000 0            
          operating lease liabilities
        		-2,525,000 -3,005,000 -1,224,000 -2,177,000 -2,219,000 -2,062,000 -1,998,000 -1,982,000 -2,041,000 -1,637,000 -1,659,000 -1,841,000 -1,504,000 -494,000 -597,000 -461,000 1,008,000 1,224,000 357,000 6,248,000 4,244,000 4,361,000 -1,025,000 -346,000 -851,000 -423,000 -661,000 -579,000 -592,000              
          other liabilities
        		-16,000 -10,000 -16,000 -16,000 -2,955,000 61,000 53,000 41,000 -2,764,000 121,000 107,000 106,000 -2,849,000 168,000 161,000 846,000 6,935,000 291,000 -30,000 66,000 -38,000 -21,000 -37,000 -10,000 -1,156,000 -16,000 -25,000 162,000 -644,000 1,814,000 -29,000 -1,056,000 957,000          
          net cash from operating activities
        		-76,186,000 -52,290,000 -55,960,000 -49,342,000 33,629,000 -31,624,000 -40,549,000 -45,497,000 -55,455,000 -40,760,000 -49,407,000 -47,322,000 -80,918,000 -39,372,000 -50,456,000 -61,749,000 -55,911,000 326,237,000 -36,359,000 -29,872,000 -41,131,000 39,468,000 -36,460,000 -21,496,000 -35,573,000 -25,506,000 -29,153,000 -23,749,000 -29,297,000 -4,140,000 -19,557,000 70,211,000 58,134,000 -13,826,000 -17,136,000 -9,549,000 -17,481,000 -20,423,000 -11,818,000 -8,430,000 -7,887,000 -4,443,000 
          capital expenditures
        		-682,000 -508,000 -491,000 -391,000 -1,024,000 -1,079,000 -326,000 -474,000 -557,000 -1,126,000 -1,439,000 -2,577,000 -4,818,000 -5,470,000 -5,050,000 -9,237,000 -10,967,000 -14,614,000 -18,698,000 -20,109,000 -27,238,000 -6,123,000 -6,072,000 -3,278,000 -4,630,000 -1,031,000 -2,679,000 -5,555,000 -2,455,000 -4,889,000 -3,372,000 -2,673,000 -2,344,000 -2,101,000 -450,000 -1,680,000  -5,070,000 -1,346,000 -558,000 6,000 -128,000 
          free cash flows
        		-76,868,000 -52,798,000 -56,451,000 -49,733,000 32,605,000 -32,703,000 -40,875,000 -45,971,000 -56,012,000 -41,886,000 -50,846,000 -49,899,000 -85,736,000 -44,842,000 -55,506,000 -70,986,000 -66,878,000 311,623,000 -55,057,000 -49,981,000 -68,369,000 33,345,000 -42,532,000 -24,774,000 -40,203,000 -26,537,000 -31,832,000 -29,304,000 -31,752,000 -9,029,000 -22,929,000 67,538,000 55,790,000 -15,927,000 -17,586,000 -11,229,000  -25,493,000 -13,164,000 -8,988,000 -7,881,000 -4,571,000 
          cash flows from investing activities
        		                                          
          purchases of marketable debt securities
        		-9,839,000 -62,811,000 -39,521,000 -211,141,000 -19,157,000 -16,223,000 -36,198,000 -82,528,000 -55,190,000 -18,639,000 -18,130,000   -11,965,000 -14,550,000 -28,874,000 -129,486,000 -235,473,000 -20,680,000 -8,364,000 -233,627,000 -43,667,000 -8,709,000 -39,973,000 -30,692,000                  
          maturities of marketable debt securities
        		81,662,000 100,857,000 82,237,000 71,096,000 64,924,000 51,792,000 86,782,000 82,734,000 68,930,000 53,739,000 56,251,000 107,590,000 67,912,000 44,135,000 72,119,000 37,030,000 49,862,000 33,700,000 49,916,000 36,005,000 50,465,000 43,586,000 43,529,000 85,446,000 60,907,000                  
          purchases of property and equipment
        		-1,235,000 -508,000 -491,000 -391,000 -1,024,000 -1,079,000 -326,000 -474,000 -557,000 -1,126,000 -1,439,000 -2,577,000 -4,818,000 -5,470,000 -5,050,000 -9,237,000 -10,967,000 -14,614,000 -18,698,000 -19,842,000 -31,021,000 -12,889,000 -6,072,000 -3,278,000 -4,630,000 -1,031,000 -2,679,000 -5,555,000 -2,455,000 -4,889,000 -3,372,000 -2,673,000 -2,344,000 -2,101,000 -450,000 -1,680,000 -2,929,000 -4,435,000 -2,223,000 -1,075,000 -416,000 -128,000 
          net cash from investing activities
        		70,588,000 37,538,000 42,287,000 -140,436,000 44,743,000 40,273,000 50,258,000 -268,000 13,183,000 33,974,000 38,657,000 55,218,000 63,094,000 26,700,000 53,043,000 -1,081,000 -90,591,000 -216,359,000 16,101,000 7,799,000 -214,183,000 11,570,000 33,998,000 44,482,000 32,709,000 14,154,000 52,272,000 21,672,000 5,461,000  -136,723,000 -38,367,000 -37,086,000 -1,143,000 18,765,000 -25,575,000 3,163,000 17,210,000 9,799,000 2,893,000 -10,739,000 -144,341,000 
          cash flows from financing activities
        		                                          
          proceeds from exercise of stock options
        		146,000 90,000 0 78,000 150,000 38,000 398,000 192,000 884,000 209,000 92,000 749,000 471,000 43,000 917,000 1,507,000 337,000 985,000 1,729,000 275,000 1,292,000 1,376,000 268,000 1,825,000 2,154,000 1,549,000 384,000 1,367,000 3,762,000 5,448,000 2,052,000 3,175,000 3,824,000 1,741,000 423,000 168,000 161,000 5,000 44,000 109,000 21,000 7,000 
          taxes paid related to net settlement of stock-based awards
        		-828,000 0 -123,000 0 -510,000 0 0 0 -910,000 0 0 0 -419,000 0 0 0 -284,000                          
          proceeds from issuance of common stock under employee stock purchase plan
        		648,000 0 741,000 0 307,000 0 780,000 0 411,000 0 1,243,000 0 583,000 0 1,120,000 0 622,000 0 1,141,000 0 627,000 0 1,192,000 0 607,000 0 949,000 0 365,000 -3,000 508,000 0 342,000 0 409,000 0 147,000      
          expenses related to at-the-market offering program
        		-230,000                                          
          repayments under royalty monetization liabilities, net of interest
        		-13,375,000 -9,651,000 -7,593,000                                        
          net cash from financing activities
        		-13,639,000 -9,584,000 -7,083,000 139,232,000 -5,794,000 -7,740,000 -10,857,000 -9,445,000 120,725,000 -11,962,000 -4,805,000 -9,162,000 -9,037,000 -8,920,000 -5,417,000 -7,669,000 -6,834,000 7,644,000 -8,427,000 -12,337,000 208,370,000 194,168,000 1,460,000 1,825,000 2,761,000 1,549,000 1,333,000 1,367,000 4,127,000 5,288,000 191,814,000 3,175,000 4,166,000 1,741,000 606,000 10,728,000 71,523,000 -55,000 44,000 109,000 21,000 -2,424,000 
          net increase in cash and cash equivalents and restricted cash
        		-19,237,000 -24,336,000 -20,756,000 -50,546,000 72,578,000 909,000 -1,148,000 -55,210,000 78,453,000         117,522,000 -28,685,000   245,206,000 -1,002,000   -9,803,000 24,452,000 -710,000 -19,709,000 -66,034,000 35,534,000 35,019,000 25,214,000          
          cash and cash equivalents and restricted cash
        		                                          
          beginning of period
        		36,496,000 0 0 0 59,556,000 0 0 0 36,552,000 0 0 0 98,982,000 0 0 0 347,239,000 0 0 0 339,756,000 0 0 0 70,844,000 0 0 0 76,614,000 0 0 0 46,881,000 0 0 0 24,840,000 0 0 0 54,116,000 0 
          end of period
        		17,259,000 -24,336,000 -20,756,000 -50,546,000 132,134,000 909,000 -1,148,000 -55,210,000 115,005,000 -18,748,000 -15,555,000 -1,266,000 72,121,000 -21,592,000 -2,830,000 -70,499,000 193,903,000 117,522,000 -28,685,000 -34,410,000 292,812,000 245,206,000 -1,002,000 24,811,000 70,741,000 -9,803,000 24,452,000 -710,000 56,905,000 -66,034,000 35,534,000 35,019,000 72,095,000 -13,228,000 2,235,000 -24,396,000 82,045,000 -3,268,000 -1,975,000 -5,428,000 35,511,000 -151,208,000 
          supplemental disclosures of non-cash investing and financing information
        		                                          
          purchases of property and equipment in accounts payable and accrued expenses and other current liabilities
        		553,000                                          
          deferred equity offering costs in accounts payable and accrued expenses and other current liabilities
        		148,000                                          
          net loss
        		 -67,149,000 -61,941,000   -51,186,000 -59,597,000 -52,989,000 -63,330,000  -61,868,000 -72,061,000 -66,676,000  -75,484,000 -68,179,000 -76,723,000  -58,405,000 -57,639,000 -50,139,000  8,791,000 -33,762,000 -40,038,000         -15,997,000 -20,706,000 -14,473,000 -21,993,000 -19,608,000 -18,154,000 -14,437,000 -10,768,000 -5,176,000 
          adjustments to reconcile net loss to net cash from operating activities
        		                                          
          provision for credit losses
        		                 -8,101,000 4,967,000 0 565,000 0                     
          net realized gain on investments
        		 0                                         
          impairment of long-lived assets
        		     0 0 0 2,101,000                                  
          sales of equity securities
        		 0        0    0    28,000                         
          proceeds from public offering of common stock and pre-funded warrants, net of issuance costs
        		     0                                     
          expenses related to at-the-market offering programs
        		                                          
          proceeds from issuance of royalty bond and warrants, net of transaction costs
        		 0 -33,000                                        
          supplemental cash flow information
        		                                          
          cash paid for income taxes
        		                                          
          cash paid for interest under royalty monetization liabilities
        		                                          
          deferred equity offering costs reclassified
        		                                          
          offering expenses related to at-the-market offering programs
        		  -75,000 -112,000 -147,000                                      
          repayments under liability related to sale of future royalties, net of imputed interest
        		    -5,594,000 -7,613,000 -11,730,000 -9,285,000 -11,226,000 -11,752,000 -10,963,000 -9,911,000 -9,672,000 -8,963,000 -7,454,000 -9,176,000 -7,509,000                          
          net amortization of premiums (accretion of discounts) on marketable debt securities
        		     -1,117,000 -1,316,000 -1,243,000 -468,000                                  
          net realized loss on investments
        		                                          
          proceeds from private placement of common stock, net of issuance costs
        		         0                                 
          cash paid for imputed interest under liability related to sale of future royalties
        		                                          
          offering expenses related to at-the-market offering program
        		      -20,000 -103,000 -35,000 -419,000                                 
          proceeds from public offering of common stock and pre-funded warrants, net of underwriting discounts and commissions
        		       0 131,601,000                                  
          issuance costs for public offering of common stock and pre-funded warrants
        		                                          
          adjustments to reconcile net income to net cash from (used in) operating activities
        		                                          
          net amortization of premiums on marketable debt securities
        		         -242,000 -133,000 380,000 682,000 903,000 1,131,000 1,218,000 1,460,000  1,506,000                        
          proceeds from public offering of common stock, net of underwriting discounts and commissions
        		                 0 0 0 216,438,000             0 0 10,695,000 71,299,000      
          issuance costs for public offering of common stock
        		                 0 0               0 -226,000 -135,000 -84,000      
          transaction costs for sale of future royalties
        		                 0 0 0 -265,000                      
          net loss on investments
        		             0 7,000                            
          imputed interest income from licensing
        		          -56,000 -40,000 -70,000 -78,000 -17,000 -153,000 -94,000 -19,000 -110,000 -202,000 -29,000 -130,000 -133,000 -1,052,000 -848,000 -860,000 -716,000 -762,000 -613,000 -584,000 -109,000 -6,898,000 -1,355,000          
          net decrease in cash and cash equivalents and restricted cash
        		          -15,555,000 -1,266,000 -26,861,000  -2,830,000 -70,499,000 -153,336,000    -46,944,000    -103,000                  
          sales of marketable debt securities
        		                     0 0                    
          proceeds from sale of future royalties
        		                                          
          net gains on investments
        		                                          
          taxes paid related to net settlement of stock options
        		                                          
          supplemental disclosures of non-cash investing and financing activities
        		                                          
          increase in accounts payable and accrued liabilities related to purchases of property and equipment
        		                                          
          non-cash additions to property and equipment through tenant improvement allowance
        		                     46,000                     
          non-cash consideration received for licenses granted
        		                     0 0           0         
          transaction costs for sale of future royalties in accounts payable and other current liabilities
        		                                          
          proceeds due to company from sales of non-marketable equity securities
        		                 -46,000                         
          net losses on investments
        		                                          
          repayments under liability related to sale of future royalties
        		                  -11,297,000 -12,484,000 -9,471,000                      
          net additions to property and equipment through accounts payable and accrued expenses
        		                                          
          net realized and unrealized losses on marketable securities
        		                   0 -7,000 -13,125,000                     
          sales of marketable equity securities
        		                     24,540,000 5,250,000 0 7,124,000                  
          additions to property and equipment through accounts payable and accrued expenses
        		                   -267,000 3,783,000 6,766,000                     
          net amortization of premiums on marketable securities
        		                    1,288,000                      
          issuance costs for public offerings of common stock
        		                    -251,000                      
          net amortization of premiums (accretion of discounts) on marketable securities
        		                                          
          deferred rent
        		                             9,000 -60,000 -8,000 27,000 32,000 -29,000 -45,000 -44,000 -25,000 701,000 148,000 453,000 48,000 
          proceeds from public offerings of common stock, net of underwriting discounts and commissions
        		                                          
          assets acquired under financing lease obligation
        		                                          
          transaction costs for sale of future royalties in accounts payable and accrued expenses
        		                                          
          net amortization of premiums and accretion of discounts on marketable debt securities
        		                       166,000 39,000 -111,000 -297,000 -420,000 -368,000 -134,000 171,000 340,000 378,000 405,000 465,000 476,000 469,000 502,000 515,000 516,000 471,000  
          net realized gains on sales and maturities of marketable securities
        		                       10,000 -7,085,000                  
          unrealized losses on marketable equity securities
        		                       -4,417,000 12,196,000                  
          net realized losses on sales and maturities of marketable securities
        		                         -5,970,000                 
          unrealized gains on marketable equity securities
        		                         -2,364,000 2,236,000                
          purchases of marketable securities
        		                         -62,810,000 -21,806,000 -26,870,000 -79,249,000 -125,932,000 -180,816,000 -84,814,000 -54,267,000 -22,041,000 0 -41,405,000 -5,188,000 -12,810,000 -1,000 -11,832,000 -20,429,000 -144,213,000 
          maturities of marketable securities
        		                         71,975,000 76,757,000 54,097,000 87,165,000 63,639,000 47,465,000 49,120,000 19,525,000 22,999,000 19,215,000 17,510,000 10,500,000 34,455,000 12,000,000 16,025,000 10,106,000  
          sales of marketable securities
        		                                 0 0 0 780,000 0     
          purchases of property and equipment in accounts payable and accrued expenses
        		                                     -635,000 877,000 517,000 422,000  
          issuance costs for public offerings of common stock in accounts payable and accrued expenses
        		                                          
          advance payments
        		                                     0 0 -35,000 -92,000 0 
          net cash from (used) in investing activities
        		                                          
          net realized losses on sales of marketable securities
        		                                          
          issuance costs for public offering of common stock in accounts payable and accrued expenses
        		                                   -135,000 328,000      
          net realized gains on sales of marketable securities
        		                                 0         
          due to related party under services agreement
        		                                         0 
          other related party payables
        		                                         -349,000 
          restricted cash
        		                                     0 0    
          proceeds from issuance of series c convertible preferred stock, net of transaction costs
        		                                         0 
          proceeds from issuance of series d convertible preferred stock, net of transaction costs
        		                                         0 
          proceeds from initial public offering of common stock, net of transaction costs
        		                                          
          net increase in cash and cash equivalents
        		                                 -13,228,000 2,235,000 -24,396,000 57,205,000 -3,268,000 -1,975,000 -5,428,000 -18,605,000 -151,208,000 
          cash and cash equivalents
        		                                          
          cash paid for interest
        		                                         0 
          conversion of accrued service fees to related party into series c convertible preferred stock
        		                                          
          conversion of related party promissory notes into series c convertible preferred stock
        		                                         0 
          conversion of convertible preferred stock into common stock upon initial public offering
        		                                         0 
          realized gains on sales of marketable securities
        		                                   0 -480,000      
          issuance costs for potential public offering of common stock
        		                                          
          proceeds from related party promissory notes
        		                                          
          deferred issuance costs for potential public offering of common stock in accrued expenses
        		                                          
          deferred issuance costs for series c convertible preferred stock in accrued expenses
        		                                          
          unrealized foreign currency transaction gains
        		                                          
          imputed interest on related party promissory notes
        		                                         0 
          proceeds from initial public offering of common stock, net of underwriting discounts and commissions
        		                                          
          issuance costs for initial public offering
        		                                          
          issuance costs for initial public offering in accounts payable and accrued expenses
        		                                          
          deferred issuance costs for initial public offering in accrued expenses
        		                                          
          unrealized foreign currency transaction losses
        		                                        -13,000  
          trade receivables
        		                                         -1,542,000 
          related party receivables
        		                                         0 
          unbilled receivables
        		                                         0 
          proceeds from issuance of series b preferred units, net of transaction costs
        		                                          
          conversion of accrued service fees to related party into series b preferred units
        		                                          
          amortization of premiums on marketable debt securities
        		                                          
          accrued expenses
        		                                          
          payments of initial public offering costs
        		                                          
          conversion of accrued service fees into series c convertible preferred stock
        		                                          
          purchases of property and equipment in accounts payable