7Baggers

Regulus Therapeutics Inc
(NASDAQ:RGLS) 

RGLS stock logo

Regulus Therapeutics Inc., a clinical stage biopharmaceutical company, engages in the discovery and development of drugs that target microRNAs to treat a range of diseases in the United States. Its product candidates include RG-012, an anti-miR targeting miR-21 that is in clinical trial for the trea...

Founded: 2007
Full Time Employees: 24
Sector: Healthcare
Industry: Biotechnology
Pharmaceuticals
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Quarterly
Annual
    Unit: USD2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 
                                                       
      operating expenses:
    		                                                   
      research and development
    		6,819,000 9,672,000 11,347,000 8,309,000 6,040,000 5,763,000 5,488,000 4,976,000 4,925,000 4,713,000 5,310,000 4,708,000 3,679,000 4,409,000 5,915,000 4,150,000 3,320,000 3,951,000 4,036,000 4,242,000 3,119,000 2,090,000 2,440,000 1,836,000 5,983,000 5,255,000 6,879,000 10,013,000 11,828,000 10,465,000 12,697,000 14,278,000 15,752,000 14,979,000 14,554,000 18,007,000 16,764,000 12,794,000 10,965,000 19,201,000 13,427,000 10,474,000 10,173,000 10,795,000 9,604,000 8,232,000 7,106,000 7,722,000 6,883,000 5,607,000 5,248,000 
      general and administrative
    		3,719,000 4,074,000 3,863,000 3,951,000 2,786,000 2,537,000 2,637,000 2,339,000 2,444,000 2,219,000 2,253,000 2,467,000 2,890,000 2,551,000 2,504,000 2,488,000 2,478,000 2,078,000 2,059,000 2,254,000 2,422,000 2,363,000 2,571,000 2,850,000 3,533,000 2,745,000 2,993,000 3,349,000 3,773,000 3,259,000 2,736,000 7,057,000 3,959,000 4,782,000 4,842,000 3,664,000 5,103,000 5,427,000 4,245,000 5,814,000 3,644,000 3,278,000 2,569,000 2,954,000 2,732,000 1,884,000 1,917,000 1,723,000 1,905,000 1,934,000 1,093,000 
      total operating expenses
    		10,538,000 13,746,000 15,210,000 12,260,000 8,826,000 8,300,000 8,125,000 7,315,000 7,369,000 6,932,000 7,563,000 7,175,000 6,569,000 6,960,000 8,419,000 6,638,000 5,798,000 6,029,000 6,095,000 6,496,000 5,541,000 4,453,000 5,011,000 4,686,000 9,516,000 8,000,000 9,872,000 13,362,000 15,601,000 13,724,000 15,433,000 21,335,000 19,711,000 19,761,000 19,396,000 21,671,000 21,867,000 18,221,000 15,210,000 25,015,000 17,071,000 13,752,000 12,742,000 13,749,000 12,336,000 10,116,000 9,023,000 9,445,000 8,788,000 7,541,000 6,341,000 
      income from operations
    		-10,538,000 -13,746,000 -15,210,000 -12,260,000 -8,826,000 -8,300,000 -8,125,000 -7,315,000 -7,369,000 -6,932,000 -7,563,000 -7,175,000 -6,569,000 -6,960,000 -8,419,000 -6,638,000 -5,798,000 -1,029,000 -1,095,000 -6,496,000 -5,535,000 -4,435,000 -4,993,000 -4,668,000 -2,738,000 -7,982,000 -9,854,000 -13,344,000 -15,583,000 -13,706,000 -15,415,000 -21,317,000 -19,693,000 -19,743,000 -19,192,000 -21,188,000 -21,378,000 -7,361,000 -13,345,000 -21,181,000 -12,871,000 -9,533,000 -11,659,000 -13,013,000 -10,705,000 -4,662,000 -2,905,000 -4,686,000 -5,550,000 -4,303,000 -3,532,000 
      yoy
    		19.40% 65.61% 87.20% 67.60% 19.77% 19.73% 7.43% 1.95% 12.18% -0.40% -10.17% 8.09% 13.30% 576.38% 668.86% 2.19% 4.75% -76.80% -78.07% 39.16% 102.15% -44.44% -49.33% -65.02% -82.43% -41.76% -36.08% -37.40% -20.87% -30.58% -19.68% 0.61% -7.88% 168.21% 43.81% 0.03% 66.09% -22.78% 14.46% 62.77% 20.23% 104.48% 301.34% 177.70% 92.88% 8.34% -17.75%     
      qoq
    		-23.34% -9.63% 24.06% 38.91% 6.34% 2.15% 11.07% -0.73% 6.30% -8.34% 5.41% 9.23% -5.62% -17.33% 26.83% 14.49% 463.46% -6.03% -83.14% 17.36% 24.80% -11.18% 6.96% 70.49% -65.70% -19.00% -26.15% -14.37% 13.69% -11.09% -27.69% 8.25% -0.25% 2.87% -9.42% -0.89% 190.42% -44.84% -37.00% 64.56% 35.02% -18.23% -10.40% 21.56% 129.62% 60.48% -38.01% -15.57% 28.98% 21.83%  
      operating margin %
    		-Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% NaN% NaN% NaN% -20.58% -21.90% NaN% -92250.00% -24638.89% -27738.89% -25933.33% -40.40% -44344.44% -54744.44% -74133.33% -86572.22% -76144.44% -85638.89% -118427.78% -109405.56% -109683.33% -9407.84% -4386.75% -4371.78% -67.78% -715.55% -552.45% -306.45% -225.95% -1076.55% -1768.07% -656.35% -85.48% -47.48% -98.47% -171.40% -132.89% -125.74% 
      other income:
    		                                                   
      interest and other income
    		921,000 968,000 1,153,000 1,283,000 438,000 353,000 438,000 471,000 415,000 333,000 187,000 79,000 6,000 41,000 1,000 821,000 1,000 106,000 38,000 10,000 79,000 42,000 87,000 191,000 56,000 -24,000 201,000 118,000 164,000 193,000 160,000 184,000 214,000 236,000 237,000 180,000 190,000 169,000 335,000 151,000 199,000 105,000 86,000 97,000 100,000 85,000 72,000 63,000 72,000   
      interest and other expense
    		-17,000 -13,000 -5,000 -58,000 -81,000 -114,000 -137,000 -168,000 -185,000 -196,000 -175,000 -162,000 -155,000 -214,000 -210,000 -216,000 -216,000 -392,000 -466,000 -461,000 -489,000 -500,000 -517,000 -538,000 -578,000 -462,000 -620,000 -621,000 -605,000 -993,000 -580,000 -603,000 -546,000 -508,000 -560,000 -90,000 -24,000               
      income before income taxes
    		-9,634,000 -12,791,000 -14,062,000 -11,035,000 -8,469,000 -8,061,000 -7,824,000 -7,012,000 -7,139,000 -6,795,000 -7,551,000 -7,258,000 -6,718,000 -7,133,000 -8,628,000 -6,033,000 -6,013,000 -1,315,000 -1,523,000 -6,947,000 -5,945,000 -4,893,000 -5,423,000 -5,015,000 -3,260,000 -8,501,000 -10,273,000 -13,847,000 -16,024,000 -14,506,000 -15,835,000 -21,736,000 -20,025,000 -20,015,000 -19,515,000 -21,098,000 -21,212,000 -7,222,000 -13,016,000 -21,037,000 -14,491,000 -22,168,000 -9,798,000 -11,973,000 -12,740,000 -1,946,000 -2,169,000 -7,338,000 -7,239,000 -6,858,000 -5,691,000 
      net income
    		-9,634,000 -12,791,000 -14,062,000 -11,036,000      -6,795,000 -7,551,000           -3,424,750 -5,423,000 -5,016,000 -3,260,000 -8,563,000 -10,273,000 -13,847,000 -16,025,000 -14,448,000 -15,828,000 -21,608,000 -20,021,000 -20,020,000 -19,519,000 -21,090,000 -21,207,000 -7,226,000 -13,000,000 -21,035,000 -14,487,000 -22,168,000 -9,798,000 -11,973,000 -12,741,000 -1,927,000 -2,164,000 -7,348,000 -7,229,000 -6,876,000 -5,685,000 
      yoy
    		                     -60.01% -47.21% -63.78% -79.66% -40.73% -35.10% -35.92% -19.96% -27.83% -18.91% 2.46% -5.59% 177.06% 50.15% 0.26% 46.39% -67.40% 32.68% 75.69% 13.70% 1050.39% 352.77% 62.94% 76.25% -71.97% -61.93%     
      qoq
    		-24.68% -9.04% 27.42%       -10.01%            -36.85% 8.11% 53.87% -61.93% -16.65% -25.81% -13.59% 10.92% -8.72% -26.75% 7.93% 0.00% 2.57% -7.45% -0.55% 193.48% -44.42% -38.20% 45.20% -34.65% 126.25% -18.17% -6.03% 561.18% -10.95% -70.55% 1.65% 5.13% 20.95%  
      net income margin %
    		-Infinity% -Infinity% -Infinity% -Infinity% NaN% NaN% NaN% NaN% NaN% -Infinity% -Infinity% NaN% NaN% NaN% NaN% NaN% NaN% 0% 0% NaN% 0% -19026.39% -30127.78% -27866.67% -48.10% -47572.22% -57072.22% -76927.78% -89027.78% -80266.67% -87933.33% -120044.44% -111227.78% -111222.22% -9568.14% -4366.46% -4336.81% -66.54% -697.05% -548.64% -344.93% -525.43% -904.71% -1626.77% -781.18% -35.33% -35.37% -154.40% -223.26% -212.35% -202.39% 
      other comprehensive loss:
    		                                                   
      unrealized loss on short-term investments
    		-40,000           -36,000                                        
      comprehensive loss
    		-9,674,000 -12,861,000 -13,855,000 -11,078,000 -8,514,000 -8,061,000 -7,824,000 -7,013,000 -7,127,000 -6,776,000 -7,546,000 -7,294,000          -3,424,750 -5,423,000 -5,016,000 -3,260,000 -8,633,000 -10,257,000 -13,800,000 -16,018,000 -14,478,000 -15,844,000 -21,598,000 -19,995,000 -20,030,000 -19,549,000 -21,081,000 -21,167,000 -7,258,000 -12,960,000 -21,037,000 -14,434,000 -22,299,000 -9,822,000 -11,956,000 -12,784,000 -1,899,000 -2,127,000 -7,392,000 -7,214,000 -6,905,000 -5,675,000 
      net income per share
    		-0.15 -0.19 -0.21 -0.17 -0.29 2.77 -0.4 -0.37 -0.42 3.32 -0.5 -0.5 -0.05 -0.06 -0.1 -0.08 -0.08 0.02 -0.04 -0.23 -0.25 -0.22 -0.26 -0.3 -0.31 -0.97 -1.18 -0.13 -0.15 -0.08 -0.18 -0.41 -0.38 -0.38 -0.37 -0.4 -0.4    -0.29    -0.3   -0.2 -0.2 38.91 -15.98 
      weighted-average shares used for eps calculation
    		66,174,550 56,346,033 65,471,132 64,465,185 28,746,802 18,960,401 19,628,815 19,101,969 16,844,243 15,259,958 14,969,574 14,612,312 145,973,989 85,704,535 87,042,437 77,175,831 71,290,918 34,977,378 38,137,281 29,801,974 24,064,373 17,260,176 20,849,083 16,705,587 10,379,830 8,718,563 8,703,626 104,319,555 104,018,273 75,230,762 90,072,045 53,182,330 52,990,383 52,813,474 52,835,414 52,782,643 52,710,672 51,411,353              
      income tax expense
    		   -1,000    -1,000     -1,000           -1,000                 -4,000    1,000   10,000 -10,000 18,000 -6,000 
      unrealized gain on investments
    		 30,000 207,000  -45,000                                               
      unrealized loss on investments
    		   -42,000                                                
      net loss and comprehensive loss
    		    -8,469,000 -5,494,000 -7,824,000 -7,013,000 -7,139,000   -7,258,000 -6,719,000 -5,168,750 -8,628,000 -6,034,000 -6,013,000 -3,602,000 -1,524,000 -6,947,000 -5,937,000                               
      unrealized gain on short-term investments
    		        12,000 -7,750 5,000               17,500 16,000 47,000 7,000 -30,000 -16,000 10,000 26,000 -10,000 -30,000 9,000 40,000 -32,000 40,000 -2,000 58,000 -131,000 -24,000 17,000 -43,000 28,000 37,000 -44,000 15,000 -29,000 10,000 
      revenues:
    		                                                   
      revenue under collaborations
    		                 5,000,000 5,000,000  6,000                               
      total revenues
    		                 5,000,000 5,000,000  6,000 18,000 18,000 18,000 6,778,000 18,000 18,000 18,000 18,000 18,000 18,000 18,000 18,000 18,000 204,000 483,000 489,000 10,860,000 1,865,000 3,834,000 4,200,000 4,219,000 1,083,000 736,000 1,631,000 5,454,000 6,118,000 4,759,000 3,238,000 3,238,000 2,809,000 
      yoy
    		              NaN% NaN% NaN% 27677.78% 27677.78% NaN% -99.91% 0.00% 0.00% 0.00% 37555.56% 0.00% 0.00% 0.00% 0.00% 0.00% -91.18% -96.27% -96.32% -99.83% -89.06% -87.40% -88.36% 157.41% 72.21% 420.92% 157.51% -22.64% -82.30% -84.53% -49.63% 68.44% 117.80%     
      qoq
    		              NaN% NaN% NaN% 0.00% NaN% NaN% -66.67% 0.00% 0.00% -99.73% 37555.56% 0.00% 0.00% 0.00% 0.00% 0.00% 0.00% 0.00% 0.00% -91.18% -57.76% -1.23% -95.50% 482.31% -51.36% -8.71% -0.45% 289.57% 47.15% -54.87% -70.10% -10.85% 28.56% 46.97% 0.00% 15.27%  
      income tax benefit
    		             -250  -1,000  1,750 -1,000  8,000        -1,000 58,000 7,000 128,000 4,000 -5,000 -4,000 8,000 5,000 -4,000 16,000 2,000      -1,000 -5,000     
      revenue under strategic alliances and collaborations
    		                     1,703,500 18,000 18,000 6,778,000 18,000 18,000 18,000 18,000 18,000 18,000 18,000 18,000 18,000 204,000 483,000 489,000 10,860,000 1,865,000 3,834,000 4,200,000 4,219,000 1,083,000 736,000 1,631,000 5,454,000 6,118,000 4,759,000 3,238,000   
      loss from valuation of convertible note payable
    		                                        -1,811,000    -2,124,000   -2,697,000 -1,761,000 -82,750 -331,000 
      interest expense
    		                                     -5,500 -6,000 -7,000 -8,000 -8,000 -10,000 -10,000 -11,000 -11,000 -7,000 -18,000  47,000 -110,000 
      gain from valuation of convertible note payable
    		                                     -452,750    153,500 1,785,000         
      net income per share
    		-0.15 -0.19 -0.21 -0.17 -0.29 2.77 -0.4 -0.37 -0.42 3.32 -0.5 -0.5 -0.05 -0.06 -0.1 -0.08 -0.08 0.02 -0.04 -0.23 -0.25 -0.22 -0.26 -0.3 -0.31 -0.97 -1.18 -0.13 -0.15 -0.08 -0.18 -0.41 -0.38 -0.38 -0.37 -0.4 -0.4    -0.29    -0.3   -0.2 -0.2 38.91 -15.98 
      basic
    		                                     -0.238 -0.25 -0.41  -0.2 -0.23 -0.28  -0.113 -0.05     
      diluted
    		                                     -0.238 -0.25 -0.41  -0.2 -0.26 -0.29  -0.113 -0.07     
      weighted-average shares used for eps calculation
    		66,174,550 56,346,033 65,471,132 64,465,185 28,746,802 18,960,401 19,628,815 19,101,969 16,844,243 15,259,958 14,969,574 14,612,312 145,973,989 85,704,535 87,042,437 77,175,831 71,290,918 34,977,378 38,137,281 29,801,974 24,064,373 17,260,176 20,849,083 16,705,587 10,379,830 8,718,563 8,703,626 104,319,555 104,018,273 75,230,762 90,072,045 53,182,330 52,990,383 52,813,474 52,835,414 52,782,643 52,710,672 51,411,353              
      basic
    		                                      51,990,460 51,073,488   43,406,251 43,362,483   40,154,812     
      diluted
    		                                      51,990,460 51,073,488   44,855,463 44,799,536   41,555,660     
      shares used to compute basic and diluted net loss per share
    		                                        50,071,165    42,690,200   35,994,642 35,872,606 7,955,856 355,735 
      gain from valuation of convertible notes payable
    		                                           953,000        
      loss on extinguishment of debt
    		                                                  -1,738,000 
      gain from changes in valuation of convertible note payable
    		                                             -946,750 671,000     
      revenue under strategic alliances
    		                                                 2,365,500 2,809,000 
      interest income
    		                                                 18,500 20,000 
      other income
    		                                                   
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 
                                                         
        assets
      		                                                   
        current assets:
      		                                                   
        cash and cash equivalents
      		49,460,000 38,528,000 26,373,000 17,122,000 29,586,000 23,767,000 25,833,000 37,263,000 30,308,000 24,228,000 20,014,000 35,119,000 53,902,000 60,383,000 35,848,000 41,440,000 31,597,000 31,087,000 17,843,000 23,419,000 28,052,000 34,121,000 14,646,000 19,571,000 10,320,000 13,935,000 14,084,000 13,485,000 10,057,000 13,519,000 20,222,000 12,538,000 14,889,000 14,941,000 14,706,000 27,040,000 19,249,000 15,960,000 18,324,000 21,084,000 19,600,000 37,327,000 9,958,000 10,024,000 8,476,000 17,807,000 33,490,000 19,170,000 17,822,000 40,552,000 17,426,000 
        short-term investments
      		15,908,000 37,249,000 60,936,000 77,338,000 67,968,000  4,949,000   14,932,000 25,310,000 12,415,000               6,433,000 19,371,000 35,077,000 46,555,000 51,148,000 27,549,000 42,575,000 61,170,000 76,877,000 80,502,000 85,849,000 98,103,000 112,002,000 118,284,000 129,191,000 122,416,000 84,107,000 93,477,000 106,121,000 96,198,000 90,413,000 63,545,000 72,893,000 57,548,000 13,467,000 
        restricted cash
      		62,000 62,000 62,000 62,000 62,000 62,000 62,000 62,000 62,000 62,000 62,000 62,000 62,000 62,000 62,000 62,000 62,000                  80,000 462,000 918,000 1,256,000 1,400,000             
        prepaid materials
      		3,471,000 3,491,000 3,229,000 3,183,000 3,010,000 3,010,000 3,010,000 3,010,000 3,010,000 3,010,000 3,010,000 3,010,000 3,010,000 3,010,000 3,010,000 3,269,000 3,314,000 3,314,000 3,388,000 3,923,000 3,924,000 3,924,000 3,826,000 3,826,000 3,826,000 4,194,000 4,194,000 4,655,000 4,655,000 4,783,000 5,912,000 6,149,000 6,212,000 5,552,000                  
        prepaid expenses and other current assets
      		2,793,000 3,015,000 1,087,000 2,633,000 821,000 1,340,000 1,228,000 1,025,000 1,178,000 1,847,000 977,000 790,000 951,000 1,780,000 1,066,000 1,348,000 1,492,000 1,826,000 1,076,000 573,000 955,000 1,221,000 358,000 556,000 801,000 1,140,000 717,000 1,536,000 1,451,000 1,506,000 1,752,000 3,018,000 3,534,000 4,154,000                  
        total current assets
      		71,694,000 82,345,000 91,687,000 100,338,000 101,447,000 28,179,000 35,082,000 41,363,000 34,562,000 44,079,000 49,373,000 51,396,000 57,933,000 65,235,000 39,986,000 46,313,000 36,537,000 36,730,000 26,307,000 28,589,000 33,607,000 40,407,000 19,529,000 24,284,000 17,739,000 19,295,000 25,441,000 39,231,000 51,428,000 66,736,000 79,566,000 49,944,000 67,649,000 87,474,000 102,830,000 116,234,000 115,759,000 134,258,000 136,810,000 144,089,000 158,517,000 164,951,000 98,023,000 107,884,000 118,229,000 117,182,000 125,286,000 86,873,000 91,769,000 98,929,000 34,359,000 
        property and equipment
      		1,121,000 937,000 1,023,000 1,083,000 1,086,000 1,061,000 1,008,000 482,000 493,000 536,000 513,000 526,000 394,000 281,000 277,000 284,000 219,000 472,000 574,000 684,000 801,000 921,000 1,042,000 974,000 1,598,000 7,806,000 8,324,000 8,906,000 9,305,000 9,708,000 10,172,000 10,753,000 11,270,000 11,830,000 12,042,000 12,322,000 10,956,000 5,400,000 3,488,000 3,310,000 3,444,000 3,568,000 3,840,000 3,948,000 3,805,000 3,768,000 3,981,000 4,011,000 3,892,000 3,310,000 3,144,000 
        intangibles
      		23,000 25,000 25,000 27,000 30,000 33,000 36,000 39,000 58,000 62,000 67,000 70,000 74,000 83,000 89,000 105,000 116,000 125,000 129,000 122,000 159,000 266,000 303,000 406,000 407,000 500,000 676,000 705,000 726,000 775,000 802,000 823,000 920,000 1,015,000 1,051,000 1,062,000 1,069,000 1,081,000 1,072,000 1,072,000 1,087,000  1,114,000 1,112,000 1,095,000  1,145,000 1,229,000 1,176,000  1,124,000 
        right of use asset
      		1,988,000 874,000 1,028,000 1,181,000 1,330,000 1,477,000 1,621,000 1,763,000 1,902,000 2,039,000 2,174,000 2,306,000 2,436,000 2,564,000 2,690,000 2,814,000 2,969,000                                   
        total assets
      		74,826,000 84,181,000 93,763,000 104,119,000 114,138,000 30,750,000 37,747,000 43,647,000 37,015,000 46,716,000 52,127,000 54,298,000 60,985,000 68,454,000 43,042,000 49,516,000 39,841,000 37,604,000 27,343,000 29,782,000 35,006,000 42,081,000 21,410,000 25,691,000 19,877,000 27,927,000 34,768,000 49,170,000 62,079,000 77,809,000 90,847,000 61,860,000 80,174,000 100,661,000 116,266,000 129,928,000 128,138,000 141,083,000 143,447,000 150,265,000 164,848,000 171,480,000 104,015,000 113,921,000 124,107,000 123,065,000 130,590,000 92,517,000 97,027,000 103,518,000 40,723,000 
        liabilities and stockholders’ equity
      		                                                   
        current liabilities:
      		                                                   
        accounts payable
      		200,000 947,000 792,000 601,000 406,000 204,000 599,000 362,000 581,000 175,000 796,000 595,000 625,000 285,000 586,000 1,393,000 810,000 535,000 1,102,000 1,024,000 1,030,000 1,321,000 1,521,000 1,602,000 2,650,000 1,714,000 1,235,000 5,468,000 4,396,000 5,743,000 5,229,000 4,901,000 4,509,000 5,840,000 5,724,000 3,504,000 3,622,000 2,717,000 3,392,000 2,407,000 2,677,000 2,188,000 2,642,000 3,018,000 2,691,000 1,172,000 1,140,000 1,028,000 398,000 311,000 649,000 
        accrued liabilities
      		808,000 746,000 1,107,000 923,000 604,000 691,000 620,000 623,000 671,000 961,000 615,000 815,000 827,000 821,000 775,000 477,000 620,000 581,000 1,089,000 1,082,000 860,000 917,000 1,212,000 1,152,000 1,745,000 4,184,000 1,856,000 2,090,000 3,371,000 4,941,000 4,770,000 4,717,000 4,690,000 5,577,000 5,066,000 5,472,000 5,456,000 6,329,000 7,409,000 6,834,000 5,318,000 4,402,000 3,633,000 4,432,000 3,279,000 3,013,000 1,705,000 2,081,000 2,335,000 658,000  
        accrued research and development expenses
      		1,149,000 765,000 1,366,000 1,068,000 700,000 921,000 793,000 756,000 538,000 1,252,000 1,081,000 755,000 608,000 810,000 2,347,000 762,000 726,000 1,097,000                                  
        accrued compensation
      		1,443,000 3,892,000 2,453,000 1,870,000 1,185,000 2,979,000 2,138,000 1,530,000 1,022,000 2,205,000 1,698,000 1,393,000 858,000 2,016,000 1,427,000 1,158,000 802,000 1,743,000 1,260,000 938,000 532,000 1,676,000 925,000 829,000 1,915,000 1,601,000 1,292,000 1,223,000 1,116,000 1,985,000 1,687,000 1,433,000 1,306,000 2,318,000 2,290,000 1,863,000 1,211,000 2,392,000 1,999,000 2,274,000 1,049,000 2,108,000 1,444,000 1,187,000 859,000 1,297,000 1,228,000 1,020,000 759,000 1,348,000  
        other current liabilities
      		797,000 1,149,000 764,000 801,000 2,247,000 2,379,000 1,970,000 2,036,000 2,294,000 2,553,000 1,853,000 619,000 957,000 1,295,000 1,657,000 1,516,000 2,249,000 2,970,000 2,381,000 3,295,000 2,728,000 3,047,000 2,696,000 2,241,000 3,245,000  2,130,000 2,130,000 2,176,000                       
        total current liabilities
      		4,397,000 7,499,000 6,482,000 5,263,000 5,682,000 8,508,000 8,248,000 8,229,000 8,822,000 11,657,000 10,521,000 5,829,000 4,701,000 5,227,000 11,460,000 9,968,000 9,864,000 11,578,000 19,479,000 20,981,000 19,786,000 21,598,000 21,004,000 20,487,000 24,840,000 26,646,000 25,654,000 30,799,000 30,933,000 32,600,000 11,758,000 11,123,000 10,577,000 13,807,000 13,152,000 11,097,000 11,012,000 12,632,000 14,809,000 14,547,000 14,351,000 35,192,000 11,893,000 11,267,000 9,568,000 10,370,000 13,527,000 19,005,000 12,693,000 12,768,000 13,407,000 
        operating lease liability, less current portion
      		1,401,000 274,000    1,055,000    1,768,000    2,417,000                                      
        total liabilities
      		5,798,000 7,773,000 6,958,000 5,938,000 6,550,000 9,563,000 9,488,000 9,650,000 10,420,000 13,425,000 12,457,000 11,931,000 11,744,000 13,496,000 14,030,000 12,688,000 12,730,000 11,578,000 19,589,000 21,198,000 20,104,000 22,066,000 21,553,000 20,948,000 25,946,000 33,781,000 33,190,000 38,737,000 39,203,000 42,593,000 42,265,000 41,865,000 41,446,000 44,586,000 43,581,000 41,482,000 20,909,000 17,005,000 17,585,000 17,638,000 18,023,000 39,466,000 29,935,000 31,838,000 31,820,000 29,608,000 36,144,000 43,196,000 41,160,000 41,425,000 49,180,000 
        commitments and contingencies
      		                                                   
        stockholders’ equity:
      		                                                   
        class a-1 convertible preferred stock, 0.001 par value...
      		                    1,000 1,000                              
        class a-2 convertible preferred stock, 0.001 par value...
      		1,000 1,000 1,000 1,000 1,000 1,000 1,000 1,000 1,000 1,000 1,000 1,000 1,000 1,000 1,000 1,000 1,000 1,000 2,000 2,000 2,000 3,000                              
        class a-3 convertible preferred stock, 0.001 par value...
      		              1,000 1,000 1,000 1,000                                  
        class a-4 convertible preferred stock, 0.001 par value...
      		4,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000                                      
        class a-5 convertible preferred stock, 0.001 par value...
      		                                                   
        class a-6 convertible preferred stock, 0.001 par value...
      		                                                   
        common stock, 0.001 par value...
      		66,000 66,000 66,000   20,000 20,000 19,000 17,000 17,000 17,000 15,000 146,000 146,000 87,000 87,000 75,000 67,000 39,000 36,000 22,000 21,000 21,000 21,000 11,000 9,000 9,000 104,000 104,000 104,000 104,000 53,000 53,000 53,000 53,000 53,000 53,000 53,000 52,000 52,000 51,000 49,000 43,000 43,000 43,000 42,000 42,000 36,000 36,000 36,000  
        additional paid-in capital
      		638,152,000 635,858,000 633,394,000   534,375,000 533,386,000 531,301,000 516,888,000 516,457,000 516,060,000 511,213,000 510,662,000 509,660,000 476,643,000 475,831,000 460,092,000 453,002,000 433,436,000 432,745,000 432,129,000 431,305,000 406,258,000 405,721,000 389,903,000 386,860,000 385,793,000 384,296,000 382,939,000 381,104,000 379,992,000 335,612,000 332,746,000 329,496,000 326,076,000 322,287,000 319,990,000 315,673,000 310,233,000 304,019,000 297,191,000 267,929,000 187,702,000 185,883,000 184,131,000 172,518,000 171,608,000 124,363,000 123,516,000 122,528,000 2,418,000 
        accumulated other comprehensive gain
      		10,000  120,000                                                 
        accumulated deficit
      		-569,205,000 -559,571,000 -546,780,000   -513,213,000 -505,152,000 -497,328,000 -490,315,000 -483,176,000 -476,381,000 -468,830,000 -461,572,000 -454,853,000 -447,720,000 -439,092,000 -433,058,000 -427,045,000 -425,723,000 -424,199,000 -417,252,000 -411,315,000 -406,422,000 -400,999,000 -395,983,000 -392,723,000 -384,161,000 -373,887,000 -360,040,000 -345,858,000 -331,410,000 -315,582,000 -293,974,000 -273,351,000 -253,331,000 -233,811,000 -212,722,000 -191,515,000 -184,289,000 -171,289,000 -150,254,000 -135,767,000 -113,599,000 -103,801,000 -91,828,000 -79,087,000 -77,160,000 -74,996,000 -67,648,000 -60,419,000 -53,543,000 
        total stockholders’ equity
      		69,028,000 76,408,000 86,805,000   21,187,000 28,259,000 33,997,000 26,595,000 33,291,000 39,670,000 42,367,000 49,241,000 54,958,000 29,012,000 36,828,000 27,111,000 26,026,000 7,754,000 8,584,000 14,902,000 20,015,000 -143,000 4,743,000   1,578,000 10,433,000 22,876,000 35,216,000 48,582,000 19,995,000 38,728,000 56,075,000 72,685,000 88,446,000 107,229,000 124,078,000 125,862,000 132,627,000 146,825,000 132,014,000 74,080,000 82,083,000 92,287,000 93,457,000 94,446,000 49,321,000 55,867,000 62,093,000  
        total liabilities and stockholders’ equity
      		74,826,000 84,181,000 93,763,000   30,750,000 37,747,000 43,647,000 37,015,000 46,716,000 52,127,000 54,298,000 60,985,000 68,454,000 43,042,000 49,516,000 39,841,000 37,604,000 27,343,000 29,782,000 35,006,000 42,081,000 21,410,000 25,691,000   34,768,000 49,170,000 62,079,000 77,809,000 90,847,000 61,860,000 80,174,000 100,661,000 116,266,000 129,928,000 128,138,000 141,083,000 143,447,000 150,265,000 164,848,000 171,480,000 104,015,000 113,921,000 124,107,000 123,065,000 130,590,000 92,517,000 97,027,000 103,518,000  
        current portion of term loan, less debt issuance costs
      		     1,334,000 2,128,000 2,922,000 3,716,000 4,511,000 4,478,000 1,652,000 826,000  4,668,000 4,662,000 4,657,000 4,652,000 13,647,000 14,642,000 14,636,000 14,631,000 14,626,000 14,621,000 15,225,000 16,575,000 19,069,000 19,888,000 19,874,000 19,859,000                      
        stockholders’ equity
      		                                                   
        accumulated other comprehensive loss
      		 50,000        -12,000 -31,000 -36,000               -63,000 -80,000 -127,000 -134,000 -104,000 -88,000 -97,000 -123,000 -113,000 -83,000 -92,000 -133,000 -134,000 -155,000 -163,000 -197,000 -66,000 -42,000 -59,000 -16,000 -44,000 -82,000 -37,000 -52,000 -23,000 
        term loan, less debt issuance costs
      		    540,000       2,794,000 3,588,000                  19,845,000 19,830,000 19,816,000 19,802,000 19,787,000 19,786,000                
        lease liability, less current portion
      		  476,000 675,000 868,000  1,240,000 1,421,000 1,598,000  1,936,000 2,102,000 2,262,000  2,570,000 2,720,000 2,866,000                                   
        long-term investments
      		   1,469,000 10,171,000                                               
        other assets
      		   21,000 74,000        148,000 291,000    277,000 333,000 387,000 439,000 487,000 536,000 27,000 133,000 326,000 327,000 328,000 620,000 590,000 307,000 340,000 335,000 342,000 343,000 310,000 354,000 344,000 2,077,000 1,794,000 1,800,000 1,811,000 1,038,000 977,000 978,000 987,000 178,000 404,000 190,000 125,000 2,096,000 
        contract and other receivables
      		       3,000 4,000    8,000   194,000 72,000 503,000 4,000,000 674,000 676,000 1,141,000 699,000 331,000 2,792,000 26,000 13,000 184,000 188,000 373,000 532,000 690,000 439,000 1,657,000 286,000 143,000 61,000 10,021,000 325,000 616,000 4,859,000    140,000       
        term loan, less current portion and debt issuance costs
      		             4,673,000                                      
        other long-term liabilities
      		           1,206,000 1,193,000 1,179,000     110,000 217,000 318,000 468,000 549,000 461,000 1,106,000 309,000 373,000 437,000 438,000  351,000 283,000 214,000 144,000 8,631,000 8,570,000 7,850,000 2,308,000 693,000 804,000 903,000 1,022,000 1,142,000 1,260,000 1,361,000 1,459,000 1,558,000 1,765,000 804,000 767,000  
        current portion of contract liabilities
      		                     6,000 24,000 42,000 60,000 2,572,000 72,000                         
        contract liabilities, less current portion
      		                         6,000 24,000 42,000 60,000                       
        deferred rent, less current portion
      		                         6,820,000 7,139,000 7,459,000 7,772,000 8,072,000 8,372,000 8,672,000 8,864,000 8,840,000                  
        liabilities and stockholders’ deficit
      		                                                   
        stockholders’ deficit:
      		                                                   
        total stockholders’ deficit
      		                        -6,069,000                          -51,148,000 
        total liabilities and stockholders’ deficit
      		                        19,877,000                          40,723,000 
        liabilities and stockholders’ (deficit) equity
      		                                                   
        total stockholders’ (deficit) equity
      		                         -5,854,000                          
        total liabilities and stockholders’ (deficit) equity
      		                         27,927,000                          
        current portion of deferred revenue
      		                             72,000 72,000 72,000 72,000 72,000 72,000 258,000 723,000 1,194,000 2,009,000 3,032,000 5,307,000 3,097,000 4,174,000 2,630,000 2,739,000 4,888,000 9,454,000 14,876,000 9,201,000 10,451,000 10,593,000 
        deferred revenue, less current portion
      		                             1,921,000 1,939,000 1,957,000 1,975,000 1,993,000 2,011,000 2,029,000 2,047,000 2,065,000 2,083,000 2,287,000 2,769,000 3,252,000 6,235,000 6,861,000 7,488,000 6,500,000 7,138,000 7,834,000 15,768,000 17,756,000 16,602,000 
        prepaid expenses
      		                                  10,614,000 7,565,000 9,272,000 8,159,000              
        other current assets
      		                                  267,000 522,000 410,000 759,000              
        convertible note payable, at fair value
      		                                         23,397,000 10,665,000         
        prepaid and other current assets
      		                                      4,759,000 4,105,000 4,867,000 4,934,000 3,958,000 4,383,000 3,492,000 3,098,000 1,288,000 1,620,000 1,054,000 829,000  
        contracts and other receivables
      		                                         274,000    79,000 95,000 2,538,000    
        intangible assets
      		                                         1,150,000    1,128,000    1,154,000  
        convertible notes payable, at fair value
      		                                           12,450,000 13,403,000 11,279,000 13,921,000 14,592,000 11,895,000 10,134,000 7,069,000 
        convertible note payable
      		                                                   
        series a convertible preferred stock, 0.001 par value...
      		                                                  32,691,000 
        series b convertible preferred stock, 0.001 par value...
      		                                                  10,000,000 
        contract receivable
      		                                                  3,000,000 
        prepaids and other current assets
      		                                                  466,000 
        accrued payroll
      		                                                  973,000 
        accrued expenses
      		                                                  1,077,000 
        income taxes payable
      		                                                   
        current portion of other long-term obligations
      		                                                  115,000 
        convertible notes payable
      		                                                  10,000,000 
        accrued interest on convertible notes payable
      		                                                  1,227,000 
        other long-term obligations, less current portion
      		                                                  374,000 
        deferred rent
      		                                                  501,000 
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 
                                                          
          operating activities
        		                                                  
          net loss
        		-9,634,000 -12,791,000 -14,062,000 -11,036,000 -8,469,000 -8,061,000 -7,824,000 -7,013,000 -7,139,000 -6,795,000 -7,551,000 -7,258,000 -6,719,000 -7,133,000 -8,628,000 -6,034,000 -6,013,000  -1,524,000 -6,947,000 -5,937,000    -3,260,000  -10,273,000 -13,848,000 -16,025,000 -14,448,000 -15,828,000 -21,608,000 -20,021,000 -20,020,000 -19,520,000 -21,089,000 -21,207,000 -7,226,000 -13,000,000 -21,035,000 -14,487,000 -22,168,000 -9,798,000 -11,973,000 -12,741,000 -1,927,000 -2,164,000 -7,348,000 -7,229,000 -6,876,000 
          adjustments to reconcile net loss to net cash from operating activities
        		                                                  
          depreciation and amortization expense
        		85,000 87,000 90,000 89,000 81,000 76,000 56,000 47,000 48,000 33,000 32,000 31,000 26,000 41,000 38,000 45,000 335,000 105,000 114,000 122,000 126,000 131,000 127,000 171,000 502,000 590,000 551,000 558,000 563,000 582,000 585,000 658,000 699,000 687,000 661,000 509,000 419,000 414,000 379,000 404,000 394,000 392,000 398,000 346,000 354,000 364,000 367,000 340,000 289,000 276,000 
          stock-based compensation
        		2,249,000 2,463,000 2,422,000 1,865,000 985,000 1,036,000 973,000 382,000 410,000 397,000 360,000 420,000 1,000,000 671,000 807,000 754,000 691,000 470,000 692,000 629,000 823,000 472,000 538,000 319,000 959,000 1,067,000 1,390,000 1,357,000 1,627,000 1,111,000 1,284,000 2,866,000 2,381,000 3,419,000 3,467,000 2,237,000 3,749,000 3,761,000 2,635,000 5,869,000 3,103,000 2,329,000 1,627,000 1,683,000 1,400,000 898,000 978,000 759,000 787,000 818,000 
          amortization of premiums and accretion of discounts on investments
        		-200,000 -385,000 -593,000 -709,000 130,000 -50,000 -51,000 0 -56,000                                          
          other
        		 0 0 10,000 32,000 28,000 32,000 50,000 31,000 32,000 31,000 32,000 38,000 7,000 17,000 12,000 10,000 6,000 5,000 38,000 105,000 31,000 111,000 12,000 139,000 574,000 73,000 16,000 93,000 394,000 16,000 55,000 135,000 705,000 293,000                
          change in operating assets and liabilities:
        		                                                  
          prepaid materials
        		21,000 -262,000 -47,000           0 259,000   74,000    -98,000 0 0 368,000 -455,000 461,000 0 128,000 754,000 237,000 63,000 -660,000                  
          prepaid expenses and other assets
        		222,000 -1,928,000 1,567,000 -1,759,000 445,000 -112,000 -202,000 152,000 669,000 -869,000 -188,000 309,000 681,000 -1,005,000 283,000 145,000 356,000 -694,000 -449,000 435,000 313,000 -814,000 -311,000 351,000 532,000 -420,000 819,000 205,000 26,000 -36,000 1,299,000 479,000 627,000                  
          accounts payable
        		-747,000 155,000 192,000 194,000 202,000 -395,000 236,000 -218,000 406,000 -621,000 200,000 -29,000 340,000 -301,000 -807,000 583,000 275,000 -567,000 78,000 -6,000 -291,000 -200,000 -81,000 -1,048,000 936,000 480,000 -4,233,000 1,071,000 -1,347,000 514,000 328,000 424,000 -1,331,000 116,000 2,220,000 -119,000 906,000 -495,000 894,000 -341,000 471,000 -530,000 -259,000 210,000 1,519,000 31,000 112,000 631,000 86,000 -337,000 
          accrued liabilities
        		-207,000 -361,000 184,000 319,000 39,000 15,000 -40,000 -81,000 -290,000 357,000 -211,000 20,000 -26,000 47,000 298,000 -119,000 14,000 -360,000 7,000 222,000 -57,000 -235,000 5,000 -598,000 120,000 -232,000 -211,000 -1,304,000 377,000 160,000 162,000 4,000 -818,000 316,000 -124,000 -467,000 -596,000 445,000 -810,000 1,560,000 899,000 -54,000 -802,000 1,451,000 -39,000 504,000 691,000 -662,000 822,000  
          accrued research and development expenses
        		384,000 -600,000 298,000 368,000 -221,000 128,000 38,000 217,000 -714,000 171,000 326,000 147,000 -202,000 -1,537,000 1,585,000 36,000 -371,000                                  
          accrued compensation
        		-2,449,000 1,440,000 583,000 685,000 -1,794,000 841,000 608,000 507,000 -1,183,000 508,000 304,000 536,000 -1,159,000 589,000 269,000 356,000 -941,000 482,000 322,000 406,000 -1,144,000 751,000 96,000 -1,086,000 314,000 309,000 68,000 107,000 -868,000 298,000 254,000 127,000 -1,012,000 28,000 427,000 652,000 -1,181,000 393,000 -276,000 1,226,000 -1,059,000 664,000 256,000 329,000 -438,000 69,000 207,000 261,000 -588,000  
          operating lease right-of-use assets and liabilities
        		-181,000 -29,000 -30,000 -28,000 -23,000 -24,000 -23,000 -22,000 -18,000 -18,000 -18,000 -16,000 -12,000 -12,000 16,000 185,000 90,000                                  
          other liabilities
        		-156,000 366,000 -53,000 -1,463,000 -149,000 393,000 -83,000 -274,000 -274,000 685,000 14,000 -339,000 -340,000 802,000 107,000 -247,000 -589,000 549,000 -952,000 -126,000 -400,000 338,000 604,000 -1,761,000 -1,076,000                          
          net cash from operating activities
        		-10,613,000 -11,845,000 -9,449,000 -11,637,000 -8,742,000 -6,125,000 -6,277,000 -6,252,000 -8,114,000 -6,253,000 -6,733,000 -6,159,000 -6,381,000 -7,831,000 -5,562,000 -5,024,000 -5,711,000 3,189,000 -4,497,000 -5,226,000 -6,002,000 -4,977,000 -4,720,000 -5,691,000 -4,433,000 -4,017,000 -11,445,000 -12,209,000 -15,602,000 -11,101,000 -11,665,000 -17,327,000 -18,680,000 -15,107,000 -15,500,000 -17,345,000 -8,930,000 -17,044,000 -11,800,000 -9,763,000 -11,252,000 -11,657,000 -8,802,000 -10,022,000 -9,029,000 -9,314,000 -4,429,000 -7,432,000 -7,155,000 851,000 
          capital expenditures
        		 0 -28,000 -83,000 -229,000 -71,000 -541,000 0 -1,000 -63,000 -3,000 -193,000 -102,000 -41,000 -26,000 -131,000 -53,000 0 0 0 0 -59,000 0 0 0 0 0 0  -86,000 -93,000 15,000 -139,000 -167,000 -480,000 129,000 -395,000 -490,000 -463,000 -174,000 -236,000 -26,000 -389,000 -656,000 -75,000 -192,000 -340,000 -191,000 -77,000 -427,000 
          free cash flows
        		 -11,845,000 -9,477,000 -11,720,000 -8,971,000 -6,196,000 -6,818,000 -6,252,000 -8,115,000 -6,316,000 -6,736,000 -6,352,000 -6,483,000 -7,872,000 -5,588,000 -5,155,000 -5,764,000 3,189,000 -4,497,000 -5,226,000 -6,002,000 -5,036,000 -4,720,000 -5,691,000 -4,433,000 -4,017,000 -11,445,000 -12,209,000  -11,187,000 -11,758,000 -17,312,000 -18,819,000 -15,274,000 -15,980,000 -17,216,000 -9,325,000 -17,534,000 -12,263,000 -9,937,000 -11,488,000 -11,683,000 -9,191,000 -10,678,000 -9,104,000 -9,506,000 -4,769,000 -7,623,000 -7,232,000 424,000 
          investing activities
        		                                                  
          purchases of short-term investments
        		     0    -2,470,000 -17,858,000                   -7,147,000 -44,086,000 -2,188,000 -2,265,000 -4,394,000 -30,485,000 -9,756,000 -20,475,000 -11,337,000 -20,783,000 -9,124,000 -37,157,000 -61,149,000 -3,967,000 -8,521,000 -39,780,000 -21,615,000 -30,406,000 -1,910,000 -18,074,000 -52,754,000 
          sales and maturities of short-term investments
        		21,500,000                         6,440,000 12,950,000 15,712,000 11,439,000 11,631,000 20,381,000 17,149,000 20,780,000 19,950,000 33,915,000 14,950,000 32,572,000 24,895,000             
          purchases of property and equipment
        		 0 -28,000 -83,000 -229,000 -71,000 -541,000 0 -1,000 -63,000 -3,000 -193,000 -102,000 -41,000 -26,000 -131,000 -53,000     -59,000    0    -86,000 -93,000 15,000 -139,000 -167,000 -480,000 129,000 -395,000 -490,000 -463,000 -174,000 -236,000 -26,000 -389,000 -656,000 -75,000 -192,000 -340,000 -191,000 -77,000 -427,000 
          net cash from investing activities
        		21,500,000 24,000,000 18,644,000 -83,000 -78,544,000 4,932,000 -5,440,000 0 14,999,000 10,467,000 -12,861,000 -12,624,000 -102,000 -41,000 -26,000 -131,000 -53,000 0    -59,000 -141,000 113,000 161,000 6,440,000 12,928,000 15,712,000 11,439,000 4,398,000 -23,798,000 14,976,000 18,360,000 15,384,000 2,936,000 5,300,000 11,691,000 13,041,000 5,499,000 10,325,000 -7,390,000 -38,840,000 8,579,000 11,537,000 -10,483,000 -6,365,000 -27,496,000 8,720,000 -15,748,000 -44,738,000 
          financing activities
        		                                                  
          proceeds from issuance of securities through private placement, net of issuance costs
        		 0 6,000 -43,000 93,897,000 -1,000 1,000               24,579,000 0                            
          proceeds from issuance of common stock
        		45,000 0 50,000 -151,000 32,000 -46,000 1,112,000 30,000 21,000 0 4,489,000 0 2,000 47,000 5,000 14,997,000 6,382,000 954,000 2,000 0 1,000 -1,000 1,000 0 2,086,000 0 11,000 0 208,000 0 43,146,000 0 265,000 0 278,000 0 363,000 0 235,000 0 257,000 76,293,000 125,000 0 9,728,000 -582,000 46,273,000 88,000 201,000  
          proceeds from exercise of common stock options
        		 0 0 1,000 2,000         -1,000 0 1,000 26,000     0 1,000   -1,000 1,000 0 1,000 0 1,000 0 3,000 1,000 44,000 59,000 206,000 1,679,000 3,346,000   1,609,000 68,000       37,000 
          payments on term loan
        		  0                                                
          net cash from financing activities
        		45,000 0 56,000 -744,000 93,105,000 -873,000 287,000 13,207,000 -805,000 0 4,489,000 0 2,000 32,407,000 -4,000 14,998,000 6,336,000 10,055,000 -1,068,000 593,000 -67,000 24,511,000 -64,000 14,829,000 657,000 -2,572,000 -884,000 -75,000 701,000 0 43,147,000 0 268,000 -42,000 230,000 19,836,000 528,000 1,639,000 3,541,000 922,000 915,000 77,866,000 157,000 33,000 10,181,000 -4,000 46,245,000 60,000 173,000 67,013,000 
          net increase in cash, cash equivalents and restricted cash
        		10,932,000                                                  
          cash,cash equivalents and restricted cash at beginning of period
        		38,590,000                                                  
          cash, cash equivalents and restricted cash at end of period
        		49,522,000                                                  
          reconciliation of cash, cash equivalents and restricted cash
        		                                                  
          cash and cash equivalents
        		49,460,000 12,155,000 9,251,000 -12,464,000 29,586,000 -2,066,000 -11,430,000 6,955,000 30,308,000 4,214,000 -15,105,000 -18,783,000 53,902,000 24,535,000 -5,592,000 9,843,000 31,597,000                                  
          restricted cash
        		62,000 0 0 0 62,000 0 0 0 62,000 0 0 0 62,000 0 0                                    
          total cash, cash equivalents and restricted cash
        		49,522,000 12,155,000 9,251,000 -12,464,000 29,648,000 -2,066,000 -11,430,000 6,955,000 30,370,000 4,214,000 -15,105,000 -18,783,000 53,964,000 24,535,000 -5,592,000 9,843,000 31,659,000                                  
          supplemental disclosure of cash flow information
        		                                                  
          interest paid
        		-5,000 -4,000 -2,000 -15,000 -45,000 -72,000 -99,000 -128,000 -148,000 -143,000 -122,000 -116,000 -110,000 -400,000 -107,000 -113,000 -109,000 -290,000 -338,000 -344,000 -384,000 -392,000 -409,000 -417,000 -437,000 -500,000 -528,000 -539,000 -506,000 -500,000 -498,000 -481,000 -465,000 -463,000 -464,000 -49,000 -5,000 -5,000 -37,000 7,000 8,000 9,000 9,000 10,000 11,000     -24,000 
          supplemental disclosure of non-cash investing and financing activities
        		                                                  
          purchases of property and equipment included in accrued liabilities
        		268,000                                                  
          sales of property and equipment
        		                     0                             
          principal payments on term loan
        		    -826,000 -826,000 -826,000 -826,000 -826,000         -9,000,000    0 0 -613,000 -1,364,000                          
          cash, cash equivalents and restricted cash at beginning of period
        		                                                  
          income taxes paid
        		 0 0   0 0   0 0 0 -1,000 0    0    0 0   0 0 0 -1,000 0 0 0 -1,000 0 0 0 -1,000 0 -2,000 0 1,000 0 0 0 1,000 0 0   1,000 
          purchases of investments
        		  -5,328,000 0 -78,315,000                                              
          sales of short-term investments
        		       0 15,000,000                                          
          net increase in cash and cash equivalents
        		  9,251,000 -12,464,000 5,819,000  -11,430,000 6,955,000 6,080,000  -15,105,000 -18,783,000 -6,481,000  -5,592,000 9,843,000 572,000 13,244,000    19,475,000 -4,925,000   -149,000     7,684,000 -2,351,000 -52,000   7,791,000 3,289,000         -15,683,000   -22,730,000 23,126,000 
          cash and cash equivalents at beginning of period
        		  0 0 23,829,000  0 0 24,290,000  0 0 60,445,000  0 0 31,087,000 0 0 0 34,121,000 0 0 0 13,935,000 0 0 0 13,519,000 0 0 0 14,941,000 0 0 0 15,960,000 0 0 0 37,327,000 0 0 0 17,807,000 0 0 0 40,552,000 0 
          cash and cash equivalents at end of period
        		  9,251,000 -12,464,000 29,648,000  -11,430,000 6,955,000 30,370,000  -15,105,000 -18,783,000 53,964,000  -5,592,000 9,843,000 31,659,000 13,244,000 -5,576,000 -4,633,000 28,052,000 19,475,000 -4,925,000 9,251,000 10,320,000 -149,000 599,000 3,428,000 10,057,000 -6,703,000 7,684,000 -2,351,000 14,889,000 235,000 -12,334,000 7,791,000 19,249,000 -2,364,000 -2,760,000 1,484,000 19,600,000 27,369,000 -66,000 1,548,000 8,476,000 -15,683,000 14,320,000 1,348,000 17,822,000 23,126,000 
          non-cash acquisition of property and equipment
        		      38,000      33,000    24,000     -58,000 55,000    0 115,000 191,000                      
          contracts and other receivables
        		       1,000 -4,000    -8,000 0 194,000 -123,000 432,000 3,497,000 -3,326,000 1,000 466,000 -442,000 -368,000 2,461,000 -2,766,000 -13,000 171,000 4,000 185,000 160,000 157,000 -251,000 1,218,000 -1,371,000 -143,000 -81,000 9,959,000 -9,696,000 0 2,419,000 -2,469,000 -246,000   -61,000 16,000 -56,000    
          maturities of investments
        		                                                  
          net decrease in cash, cash equivalents and restricted cash
        		                                                  
          maturities of short-term investments
        		                                                  
          gain on ppp loan forgiveness
        		             0 0                                    
          payments on financing leases
        		             1,000 -9,000 0 -72,000 -70,000 -70,000 -69,000 -68,000 -67,000   -65,000                          
          paycheck protection program loan forgiveness
        		             0 0                                    
          amortization of discount on investments
        		                                                  
          amortization of premium on investments
        		                         56,000 5,000 40,000 47,000 78,000 90,000 74,000 107,000 141,000 166,000 161,000 198,000 342,000 329,000 376,000 425,000 362,000 359,000 433,000 443,000 446,000 380,000 314,000 324,000 111,000 
          contract liabilities
        		                 0 0 0 -6,000 -18,000 -18,000 -18,000 -2,518,000 2,482,000 -18,000                        
          acquisition of intangibles
        		                 0    0 -15,000       0 0 0 -16,000 -5,000 -14,000 -23,000 -11,000 -27,000 -21,000 -12,000 -7,000 -12,000 -19,000   11,000 50,000 -69,000 -27,000  
          proceeds from borrowing under paycheck protection program
        		                 0 0                                
          unsettled sales of common stock through atm
        		                                                  
          income taxes (paid) refunded
        		                                                  
          restricted cash included in other assets
        		                62,000                                  
          net income
        		                     -4,893,000 -5,423,000                            
          adjustments to reconcile net income to net cash from operating activities
        		                                                  
          gain on reduction of lease liability
        		                     0 0 522,000 1,317,000                          
          net decrease in cash and cash equivalents
        		                   -4,633,000 -6,069,000    -3,615,000   3,428,000 -3,462,000          -2,760,000 1,484,000 -17,727,000  -66,000 1,548,000 -9,331,000      
          income taxes refunded
        		                                                  
          deferred rent
        		                                                  
          proceeds from financing leases
        		                                                  
          deferred rent and other liabilities
        		                         108,000 -248,000 -379,000 -408,000 -650,000 -231,000 -200,000 13,000 321,000 84,000 -349,000 87,000 -122,000 -97,000 -81,000 -79,000 -79,000 -79,000 -63,000 -61,000 -79,000 -987,000 989,000 66,000  
          sales and disposals of property and equipment
        		                       121,000 161,000                          
          (payments) proceeds of financing leases
        		                                                  
          proceeds from capital lease financing
        		                         -62,000 -63,000 -75,000 492,000                      
          proceeds from borrowing under term loan
        		                                 0 -51,000                
          net changes in restricted cash
        		                                 -80,000 -382,000 -456,000 -338,000              
          allowance for tenant improvements
        		                                 0 108,000 1,075,000 5,470,000              
          amounts accrued for property and equipment
        		                               101,000 9,000 278,000 -207,000 135,000 86,000 44,000 89,000 76,000 14,000   -184,000 301,000  -968,000 249,000 776,000  
          principal payments on other long-term obligations
        		                                 -43,000 -41,000 -42,000 -41,000 -40,000 -40,000 -38,000 -37,000 -36,000 -36,000 -36,000 -34,000 -16,000 -28,000 -28,000 -28,000 -119,000 
          loss from valuation of convertible note payable
        		                                     0 0 0 1,811,000    2,124,000  -671,000 2,697,000 1,761,000  
          deferred revenue
        		                             -18,000 -18,000 -18,000 -18,000 -18,000 -204,000 -483,000 -489,000 -833,000 -934,000 -934,000 -389,000 -4,059,000 916,000 -735,000 -1,161,000 -5,204,000 -3,618,000 -4,759,000 -3,238,000 1,013,000 
          amounts accrued for patent expenditures
        		                                  -2,000             4,000 15,000  
          unpaid debt issuance costs
        		                                                  
          prepaid expenses
        		                                  -3,049,000 1,707,000 -1,113,000              
          other assets
        		                                  222,000 -68,000 338,000              
          loss on disposal of long-term assets
        		                                     25,000 17,000 6,000 50,000 0 0 0 18,000   0 1,000  
          prepaid and other current assets
        		                                      -937,000 768,000 78,000    -385,000      
          restricted cash received
        		                                                  
          maturities and sales of short-term investments
        		                                       19,635,000 30,010,000 22,347,000 12,954,000 20,748,000 29,372,000 15,431,000 3,200,000 10,890,000 2,430,000 8,533,000 
          proceeds from exercise of stock options
        		                                        695,000    487,000      
          adjustments to reconcile net loss to net cash from operating activities:
        		                                                  
          loss from change in value of convertible note payable
        		                                                  
          loss on extinguishment of debt
        		                                                 0 
          prepaid and other assets
        		                                         -1,000,000 315,000   -1,771,000 338,000    
          proceeds from issuance of convertible notes payable and other long-term obligations
        		                                                  
          supplemental disclosures of non-cash investing and financing activities
        		                                                  
          conversion of notes payable to common stock
        		                                                  
          loss from valuation of convertible notes payable
        		                                                  
          deferred income taxes
        		                                               0 -10,000  
          gain on investments
        		                                            -1,000 -19,000 -15,000 10,000 -1,000  
          proceeds from issuance of convertible notes payable
        		                                                  
          costs paid in connection with initial public offering
        		                                                  
          prepaids and other current assets
        		                                                -225,000  
          proceeds from issuance of series b convertible preferred stock
        		                                                  
          proceeds from initial public offering and private placement of common stock, net of offering costs
        		                                                  
          supplemental disclosures of non-cash investing and financing activities conversion of notes payable to common stock
        		                                                  
          tenant improvement incentives
        		                                                  
          contract receivable
        		                                                  
          prepaids and other assets
        		                                                  
          accrued payroll
        		                                                  
          accrued expenses
        		                                                  
          accrued interest
        		                                                  
          payables to related parties
        		                                                  
          income taxes payable
        		                                                  
          acquisition of patents