7Baggers

Rocket Pharmaceuticals, Inc
(NASDAQ:RCKT) 

RCKT stock logo

Rocket Pharmaceuticals, Inc., together with its subsidiaries, operates as a multi-platform biotechnology company that focuses on developing gene therapies for rare and devastating pediatric diseases. It has four clinical-stage ex vivo lentiviral vector programs for fanconi anemia, a genetic defect i...

Founded: 1999
Full Time Employees: 84
Sector: Healthcare
Industry: Biotechnology
Pharmaceuticals
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At a glance:
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Quarterly
Annual
    Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 
                                                
      revenue
    		                                            
      yoy
    		                                            
      qoq
    		                                            
      operating expenses:
    		                                            
      research and development
    		31,454,000 29,347,000 34,068,000 42,658,000 35,942,000 37,357,000 42,315,000 46,345,000 45,227,000 41,744,000 46,844,000 51,383,000 46,371,000 50,037,000 43,383,000 41,356,000 30,794,000 32,161,000 39,975,000 24,798,000 28,542,000 51,037,000 21,657,000 16,731,000 16,957,000 14,668,000 14,829,000 13,989,000 15,137,000 23,680,000 13,065,000 10,772,000 5,743,000 -654,000 -2,818,000 -9,493,000 -8,412,000 -6,465,000 -7,615,000 -5,919,000 -3,612,000 -1,954,000 -1,069,000  
      general and administrative
    		17,057,000 14,684,000 18,351,000 25,020,000 28,446,000 25,337,000 27,109,000 27,367,000 22,148,000 21,535,000 18,585,000 17,374,000 15,823,000 19,045,000 15,105,000 12,854,000 11,770,000 12,172,000 9,671,000 9,250,000 10,680,000 8,201,000 5,730,000 6,828,000 7,163,000 4,981,000 4,336,000 4,403,000 3,808,000 2,865,000 2,268,000 4,100,000 8,662,000 -3,548,000 -3,895,000 -2,746,000 -2,311,000 -2,315,000 -2,522,000 -2,309,000 -1,825,000 -1,728,000 -1,980,000  
      total operating expenses
    		48,511,000 43,963,000 52,247,000 71,149,000 64,388,000 62,694,000 69,424,000 73,712,000 67,375,000 63,279,000 65,429,000 68,757,000 62,194,000 69,082,000 58,488,000 54,210,000 42,564,000 44,333,000 49,646,000 34,048,000 39,222,000 59,238,000 27,387,000 23,559,000 24,120,000 19,649,000 19,165,000 18,392,000 18,945,000 26,545,000 15,333,000 14,872,000 14,405,000            
      income from operations
    		-48,511,000 -43,963,000 -52,247,000 -71,149,000 -64,388,000 -62,694,000 -69,424,000 -73,712,000 -67,375,000 -63,279,000 -65,429,000 -68,757,000 -62,194,000 -69,082,000 -58,488,000 -54,210,000 -42,564,000 -44,333,000 -49,646,000 -34,048,000 -39,222,000 -59,238,000 -27,387,000 -23,559,000 -24,120,000 -19,649,000 -19,165,000 -18,392,000 -18,945,000 -26,545,000 -15,333,000 -14,872,000 -14,405,000 -4,202,000 -6,713,000 -12,239,000 -10,723,000 -8,780,000 -10,137,000 -8,228,000 -5,437,000 -3,682,000 -3,049,000  
      yoy
    		-24.66% -29.88% -24.74% -3.48% -4.43% -0.92% 6.11% 7.21% 8.33% -8.40% 11.87% 26.83% 46.12% 55.83% 17.81% 59.22% 8.52% -25.16% 81.28% 44.52% 62.61% 201.48% 42.90% 28.09% 27.32% -25.98% 24.99% 23.67% 31.52% 531.72% 128.41% 21.51% 34.34% -52.14% -33.78% 48.75% 97.22% 138.46% 232.47%      
      qoq
    		10.35% -15.86% -26.57% 10.50% 2.70% -9.69% -5.82% 9.41% 6.47% -3.29% -4.84% 10.55% -9.97% 18.11% 7.89% 27.36% -3.99% -10.70% 45.81% -13.19% -33.79% 116.30% 16.25% -2.33% 22.75% 2.53% 4.20% -2.92% -28.63% 73.12% 3.10% 3.24% 242.81% -37.41% -45.15% 14.14% 22.13% -13.39% 23.20% 51.33% 47.66% 20.76%   
      operating margin %
    		-Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity%  
      interest expense
    		-473,000 -473,000 -473,000 -473,000 -472,000 -473,000 -471,000 -471,000 -471,000 -470,000 -469,000 -468,000 -468,000 -467,000 -465,000 -465,000 -464,000 -463,000 -534,000 -251,000 -1,729,000 -1,641,000 -1,967,000 -1,786,000 -1,573,000 -1,343,000 -1,466,000 -1,544,000 -1,604,000 -2,029,000 -1,176,000 -1,363,000 -1,427,000 -913,000 -901,000 -893,000 -525,000    -192,000 -564,000 -474,000  
      interest and other income
    		161,000 690,000 709,000 483,000 1,336,000 1,617,000 1,327,000 2,294,000 3,029,000 814,000 1,720,000 846,000 1,908,000 1,245,000 1,353,000 669,000 623,000       429,000  630,500 979,000 1,000,000                 
      accretion of discount on investments
    		1,229,000 1,208,000 1,679,000 2,220,000 2,190,000 1,713,750 1,849,000 2,243,000 2,763,000               -124,000 62,000 245,000 368,000 256,000 247,000                
      net income
    		-47,594,000 -42,538,000 -50,332,000 -68,919,000 -61,334,000 -60,327,000 -66,719,000 -69,646,000 -62,054,000 -59,660,000 -61,899,000 -65,701,000 -58,335,000 -66,723,000 -57,756,000 -54,402,000 -42,982,000 -44,247,000 -50,118,000 -34,525,000 -40,179,000 -60,916,000 -29,080,000 -25,040,000 -24,664,000 -19,855,000 -19,284,000 -18,680,000 -19,451,000 -27,319,000 -16,089,000 -15,767,000 -15,343,000 -4,870,000 -7,395,000 -12,974,000 -11,128,000 -8,684,000 -10,068,000 -8,172,000 -55,961,000 -2,387,000 -1,462,000  
      yoy
    		-22.40% -29.49% -24.56% -1.04% -1.16% 1.12% 7.79% 6.00% 6.38% -10.59% 7.17% 20.77% 35.72% 50.80% 15.24% 57.57% 6.98% -27.36% 72.35% 37.88% 62.91% 206.80% 50.80% 34.05% 26.80% -27.32% 19.86% 18.48% 26.77% 460.97% 117.57% 21.53% 37.88% -43.92% -26.55% 58.76% -80.11% 263.80% 588.65%      
      qoq
    		11.89% -15.49% -26.97% 12.37% 1.67% -9.58% -4.20% 12.23% 4.01% -3.62% -5.79% 12.63% -12.57% 15.53% 6.17% 26.57% -2.86% -11.71% 45.16% -14.07% -34.04% 109.48% 16.13% 1.52% 24.22% 2.96% 3.23% -3.96% -28.80% 69.80% 2.04% 2.76% 215.05% -34.14% -43.00% 16.59% 28.14% -13.75% 23.20% -85.40% 2244.41% 63.27%   
      net income margin %
    		-Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity%  
      net income per share
    		-0.42 -0.38 -0.45 -0.62 -0.56 -0.62 -0.71 -0.74 -0.66 -0.62 -0.75 -0.82 -0.73 -0.89 -0.87 -0.83 -0.67 -0.68 -0.79 -0.55 -0.65 -1.09 -0.53 -0.45 -0.45 -0.39 -0.38 -0.38 -0.43 -0.67 -0.4 -0.4 -0.42 -0.228 -0.27 -0.28 -0.41 -0.33 -0.38 0.13 -2.48 -0.15 -0.21  
      weighted-average common shares outstanding - basic and diluted
    		112,134,059 111,123,770 111,571,136 111,019,647 110,093,461 94,807,773 94,158,491 93,746,243 93,549,884 84,009,004 82,636,120 80,472,362 79,453,519 68,148,925 66,215,535 65,476,531 64,509,721 63,235,417 63,825,429 63,061,232 61,574,405 55,380,740 55,188,956 55,158,459 54,883,120 49,010,358 50,364,649 49,267,247 45,122,815 39,377,666 39,900,551 39,483,006 36,137,120            
      restructuring
    		 -68,000 -172,000 3,471,000                                         
      accretion of discount and amortization of premium on investments
    		         3,275,000 2,279,000 2,678,000 2,419,000                                
      research and development incentives
    		                 500,000   500,000        250,000    186,000            
      amortization of premium on investments - net
    		             -282,000 -156,000 -396,000 -577,000 -527,750 -744,000 -727,000                         
      interest and other income - net
    		                 554,500 806,000 501,000                         
      interest and other income net
    		                    911,000 237,000 518,000  967,000    601,000                
      (amortization of premium) accretion of discount on investments - net
    		                    -639,000 -274,000 -244,000                      
      interest income
    		                             316,000 459,000 473,000 288,000 245,000 219,000 158,000 120,000 96,000 69,000 56,000 33,000    
      other income net
    		                             -7,000 -39,000              
      other income
    		                               -5,000 15,000            
      weighted-average number of shares outstanding—basic and diluted
    		                                  27,041,324  26,930,730  26,423,394 18,311,333 22,573,195 16,327,003 7,677,575  
      loss on extinguishment of debt
    		                                        -3,716,000  -683,000  
      change in fair value of warrant liabilities
    		                                          267,000  
      change in fair value of convertible bridge notes redemption rights derivative
    		                                          480,000  
      change in fair value of 2020 convertible notes derivative liability
    		                                        -46,649,000 1,859,000   
      weighted-average number of shares outstanding–basic and diluted
    		                                     26,623,280       
      change in fair value of 2020 convertible notes derivative
    		                                          1,997,000  
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 
                                                    
        assets
      		                                              
        current assets:
      		                                              
        cash and cash equivalents
      		49,610,000 77,558,000 75,948,000 32,819,000 49,810,000 163,635,000 65,599,000 38,607,000 35,276,000 55,904,000 225,657,000 45,076,000 64,579,000 140,517,000 196,669,000 187,548,000 130,552,000 232,694,000 245,644,000 264,608,000 252,540,000 297,098,000 82,226,000 163,203,000 190,520,000 185,383,000 89,195,000 64,833,000 124,464,000 111,355,000 38,076,000 52,548,000 171,136,000 78,720,000 49,146,000 27,610,000 25,273,000 29,798,000 83,004,000 38,519,000 58,706,000 80,042,000 89,248,000 49,012,000 53,139,000 3,618,000 
        investments
      		94,769,000 111,371,000 146,810,000 238,675,000 268,354,000 208,701,000 170,063,000 240,218,000 295,037,000 317,271,000 211,514,000 261,964,000 266,505,000 215,877,000 109,865,000 133,820,000 216,041,000 156,046,000 175,815,000 162,222,000 213,813,000 185,621,000 146,464,000 86,600,000 85,375,000 118,732,000 151,366,000 192,950,000 72,126,000 94,375,000 89,402,000 79,555,000               
        prepaid expenses and other current assets
      		5,448,000 3,805,000 4,922,000 5,661,000 6,329,000 5,847,000 6,092,000 13,900,000 14,846,000 5,047,000 9,694,000 5,034,000 6,949,000 7,666,000 4,597,000 4,403,000 7,255,000 3,319,000 3,610,000 3,596,000              1,033,000 747,000 1,067,000 1,928,000 1,876,000 1,341,000 480,000 982,000 1,086,000 859,000 465,000 301,000 52,000 
        total current assets
      		149,827,000 192,734,000 227,680,000 277,155,000 324,493,000 378,183,000 241,754,000 292,725,000 345,159,000 378,222,000 446,865,000 312,074,000 338,033,000 364,060,000 311,131,000 325,771,000 353,848,000 392,059,000 425,069,000 430,426,000 471,822,000 487,345,000 233,214,000 255,436,000 279,805,000 307,754,000 245,591,000 263,629,000 199,619,000 209,088,000 128,821,000 134,608,000 184,828,000 101,047,000 103,872,000 109,821,000 116,633,000 128,349,000 138,924,000 98,702,000 103,247,000 112,366,000 119,224,000 49,477,000 53,440,000 3,670,000 
        property and equipment
      		26,655,000 28,170,000 29,768,000 32,524,000 34,565,000 36,786,000 38,514,000 39,548,000 39,337,000 39,172,000 36,534,000 32,986,000 30,588,000 29,009,000 25,613,000 24,851,000 24,354,000 22,299,000 22,090,000 20,989,000 19,833,000 19,206,000 15,803,000 14,314,000 11,140,000 29,295,000 19,270,000 9,844,000 7,077,000 2,027,000 1,245,000 976,000 1,146,000 563,000 615,000 1,076,000 1,122,000 1,130,000 1,045,000 976,000 790,000 812,000 756,000 29,000   
        goodwill
      		39,154,000 39,154,000 39,154,000 39,154,000 39,154,000 39,154,000 39,154,000 39,154,000 39,154,000 39,154,000 39,154,000 39,154,000 39,154,000 39,154,000 30,815,000 30,815,000 30,815,000 30,815,000 30,815,000 30,815,000 30,815,000 30,815,000 30,815,000 30,815,000 30,815,000 30,815,000 30,815,000 30,815,000 30,815,000 30,815,000 30,815,000 30,815,000 30,815,000              
        intangible assets
      		25,150,000 25,150,000 25,150,000 25,150,000 25,150,000 25,150,000 25,150,000 25,150,000 25,150,000 25,150,000 25,150,000 25,724,000 25,724,000 25,724,000                                 
        restricted cash
      		1,341,000 1,340,000 1,365,000 1,365,000 1,362,000 1,362,000 1,362,000 1,362,000 1,362,000 1,372,000 1,372,000 1,362,000 1,340,000 1,340,000 1,354,000 1,343,000 1,343,000 1,343,000 1,334,000 1,334,000 1,461,000 1,568,000 1,568,000 1,525,000 1,525,000 1,525,000 1,525,000 1,525,000 1,525,000 1,436,000 1,645,000 1,644,000 208,000              
        deposits
      		482,000 482,000 515,000 515,000 514,000 529,000 503,000 481,000 533,000 533,000 542,000 542,000 459,000 608,000 455,000 455,000 455,000 455,000 455,000 455,000 455,000 455,000 455,000 455,000 455,000 455,000 455,000 455,000 455,000 545,000 455,000 168,000 168,000              
        operating lease right-of-use assets
      		3,127,000 3,210,000 3,653,000 3,830,000 4,003,000 4,173,000 4,349,000 4,551,000 4,768,000 3,901,000 4,089,000 4,345,000 4,369,000 1,972,000 1,022,000 1,207,000 1,390,000 1,569,000 1,467,000 1,628,000 1,787,000 914,000 1,094,000 1,270,000 1,470,000 2,051,000 2,254,000 2,452,000 2,647,000                  
        finance lease right-of-use asset
      		39,671,000 40,209,000 40,748,000 41,286,000 41,825,000 42,363,000 42,902,000 43,440,000 43,979,000 44,517,000 45,056,000 45,594,000 46,133,000 46,664,000 46,875,000 47,410,000 47,945,000 48,480,000 49,011,000 49,507,000 50,311,000 50,521,000 52,547,000 49,250,000 47,541,000                      
        total assets
      		285,407,000 330,449,000 368,033,000 420,979,000 471,066,000 527,700,000 393,688,000 446,411,000 499,442,000 566,341,000 598,762,000 461,781,000 514,757,000 551,807,000 417,265,000 431,852,000 460,150,000 497,020,000 530,241,000 535,154,000 576,484,000 590,824,000 335,496,000 353,065,000 372,751,000 372,121,000 299,910,000 308,720,000 242,138,000 251,313,000 194,981,000 207,574,000 217,165,000 101,778,000 104,655,000 111,065,000 117,923,000 129,647,000 140,139,000 99,851,000 104,207,000 113,321,000 120,124,000 51,688,000 55,526,000 5,520,000 
        liabilities and stockholders' equity
      		                                              
        current liabilities:
      		                                              
        accounts payable and accrued expenses
      		21,542,000 27,291,000 28,258,000 40,505,000 32,435,000 37,827,000 37,133,000 34,733,000 30,085,000 45,789,000 30,624,000 31,353,000 28,609,000 36,660,000 27,823,000 21,840,000 20,031,000 19,615,000 22,008,000 17,884,000 33,168,000 25,472,000 24,830,000 18,245,000 18,819,000 17,352,000 21,246,000 14,168,000 19,680,000 15,372,000 9,765,000 8,285,000 4,762,000              
        operating lease liabilities, current
      		998,000 1,003,000 1,015,000 1,010,000 1,006,000 1,001,000 1,005,000 1,033,000 1,064,000 925,000 1,079,000 1,233,000 849,000 773,000 634,000 737,000 838,000 863,000 804,000 792,000 683,000 626,000 728,000 819,000 817,000 957,000 935,000 913,000 892,000                  
        finance lease liability, current
      		1,926,000 1,912,000 1,897,000 1,884,000 1,870,000 1,856,000 1,842,000 1,826,000 1,808,000 1,791,000 1,773,000 1,760,000 1,748,000 1,736,000 1,724,000 1,712,000 1,701,000 1,689,000 1,677,000 1,666,000 1,655,000                          
        total current liabilities
      		24,466,000 30,206,000 31,170,000 43,399,000 35,311,000 40,684,000 39,980,000 37,592,000 32,957,000 48,505,000 33,476,000 34,346,000 31,206,000 39,169,000 30,181,000 24,289,000 22,570,000 22,167,000 24,489,000 25,444,000 40,492,000 32,617,000 31,955,000 20,685,000 21,114,000 18,309,000 22,181,000 15,081,000 20,572,000 15,372,000 10,294,000 10,146,000 7,337,000 4,070,000 3,767,000 4,016,000 5,268,000 7,212,000 5,944,000 4,071,000 4,614,000 4,141,000 3,243,000 2,452,000 2,457,000 7,220,000 
        operating lease liabilities, non-current
      		2,493,000 2,600,000 2,758,000 2,928,000 3,095,000 3,258,000 3,413,000 3,565,000 3,714,000 2,973,000 2,990,000 3,074,000 3,506,000 1,088,000 492,000 606,000 719,000 905,000 891,000 1,096,000 1,299,000 498,000 599,000 706,000 917,000 1,443,000 1,691,000 1,933,000 2,169,000                  
        finance lease liability, non-current
      		19,347,000 19,362,000 19,375,000 19,380,000 19,381,000 19,383,000 19,382,000 19,374,000 19,363,000 19,353,000 19,341,000 19,319,000 19,294,000 19,269,000 19,242,000 19,210,000 19,176,000 19,144,000 19,109,000 19,070,000                           
        other liabilities
      		1,062,000 1,060,000 1,061,000 1,061,000 1,141,000 1,141,000 1,142,000 1,245,000 1,906,000 2,936,000 1,869,000 2,072,000 1,875,000 2,595,000 37,000 51,000 65,000 80,000 94,000 107,000 122,000 136,000 23,000 23,000 23,000 23,000 23,000 22,000 23,000                  
        total liabilities
      		47,368,000 53,228,000 54,364,000 66,768,000 58,928,000 64,466,000 63,917,000 61,776,000 57,940,000 73,767,000 57,676,000 58,811,000 55,881,000 62,121,000 49,952,000 44,156,000 42,530,000 42,296,000 44,583,000 45,717,000 96,485,000 87,305,000 93,655,000 86,542,000 86,700,000 64,824,000 67,992,000 60,216,000 65,061,000 57,276,000 51,361,000 50,498,000 47,019,000 54,014,000 53,580,000 53,535,000 54,659,000 56,479,000 55,085,000 4,407,000 4,965,000 4,508,000 3,649,000 19,969,000 21,574,000 10,278,000 
        commitments and contingencies
      		                                              
        stockholders' equity:
      		                                              
        preferred stock, 0.01 par value...
      		                                              
        series a convertible preferred stock; 300,000 shares designated; 0 shares issued and outstanding
      		                                              
        series b convertible preferred stock; 300,000 shares designated; 0 shares issued and outstanding
      		                                              
        common stock, 0.01 par value...
      		1,091,000 1,083,000 1,082,000 1,079,000 1,068,000 1,065,000 911,000 910,000 906,000 903,000 901,000 805,000 804,000 791,000 678,000 658,000 645,000 645,000 644,000 634,000 619,000 610,000 552,000 551,000 551,000 548,000 503,000 503,000 451,000 452,000 398,000 395,000 394,000            163,000 10,000 
        additional paid-in capital
      		1,725,893,000 1,717,408,000 1,711,297,000 1,701,608,000 1,690,547,000 1,680,219,000 1,486,436,000 1,475,013,000 1,462,155,000 1,450,722,000 1,440,403,000 1,240,745,000 1,230,319,000 1,203,074,000 1,014,283,000 977,099,000 952,498,000 946,152,000 932,776,000 886,431,000 842,477,000 825,794,000 503,223,000 498,590,000 493,811,000 489,925,000 394,930,000 392,205,000 302,039,000 300,253,000 221,983,000 219,225,000 216,440,000 316,086,000 314,332,000 313,441,000 312,613,000 311,829,000 310,686,000 309,933,000 305,069,000 304,583,000 304,062,000 163,446,000 163,292,000 76,472,000 
        accumulated other comprehensive income
      		-112,000 -31,000 -9,000 -107,000 -27,000 66,000 213,000 -218,000 -135,000 319,000            -42,000    20,000 117,000 144,000     10,000      2,000 17,000       
        accumulated deficit
      		-1,488,833,000 -1,441,239,000 -1,398,701,000 -1,348,369,000 -1,279,450,000 -1,218,116,000 -1,157,789,000 -1,091,070,000 -1,021,424,000 -959,370,000 -899,710,000 -837,811,000 -772,110,000 -713,775,000 -647,052,000 -589,296,000 -534,894,000 -491,912,000 -447,665,000 -397,547,000 -363,022,000 -322,843,000 -261,927,000 -232,847,000 -207,807,000 -183,143,000 -163,288,000 -144,004,000 -125,324,000 -105,873,000 -78,554,000 -62,465,000 -46,698,000 -268,374,000 -263,504,000 -256,109,000 -249,547,000 -238,877,000 -225,903,000 -214,775,000 -206,091,000 -196,023,000 -187,851,000 -131,890,000 -129,503,000 -128,041,000 
        total stockholders’ equity
      		238,039,000 277,221,000 313,669,000 354,211,000        402,970,000 458,876,000 489,686,000 367,313,000 387,696,000 417,620,000 454,724,000    503,519,000    307,297,000 231,918,000 248,504,000      47,764,000 51,075,000 57,530,000 63,264,000 73,168,000 85,054,000 95,444,000 99,242,000 108,813,000 116,475,000 31,719,000 33,952,000  
        total liabilities and stockholders’ equity
      		285,407,000 330,449,000 368,033,000 420,979,000        461,781,000 514,757,000 551,807,000 417,265,000 431,852,000 460,150,000 497,020,000    590,824,000    372,121,000 299,910,000 308,720,000      101,778,000 104,655,000 111,065,000 117,923,000 129,647,000 140,139,000 99,851,000 104,207,000      
        total stockholders' equity
      		    412,138,000 463,234,000 329,771,000 384,635,000 441,502,000 492,574,000 541,086,000        485,658,000 489,437,000 479,999,000  241,841,000 266,523,000 286,051,000                      
        total liabilities and stockholders' equity
      		    471,066,000 527,700,000 393,688,000 446,411,000 499,442,000 566,341,000 598,762,000        530,241,000 535,154,000 576,484,000  335,496,000 353,065,000 372,751,000                      
        series a convertible preferred stock; 300,000 shares designated as series a; 0 shares issued and outstanding
      		                                              
        series b convertible preferred stock; 300,000 shares designated as series b; 0 shares issued and outstanding
      		                                              
        treasury stock
      		           -47,000 -47,000 -47,000         -76,000  -429,000 -53,000 -344,000 -344,000  -668,000                 
        accumulated other comprehensive loss
      		          -508,000 -722,000 -90,000 -357,000 -596,000 -765,000 -629,000 -161,000 -97,000 -81,000 -75,000  69,000 229,000 -75,000    -89,000 -127,000 -207,000 -79,000  -16,000 -25,000 -72,000 -72,000 -54,000         
        liabilities and stockholders’ equity
      		                                              
        stockholders’ equity:
      		                                              
        convertible notes, net of unamortized discount, current
      		                   5,102,000 4,986,000 4,875,000 4,765,000                        
        convertible notes, net of unamortized discount, non-current
      		                    35,544,000 35,066,000 42,132,000                        
        prepaid expenses and other assets
      		                    5,469,000 4,626,000 4,524,000 5,633,000 3,910,000 3,639,000 5,030,000 5,846,000 3,029,000 3,358,000 1,343,000 2,505,000 2,131,000              
        finance lease liabilities, non-current
      		                    19,028,000 18,988,000 18,946,000 18,900,000 18,852,000                      
        finance lease liabilities, current
      		                     1,644,000 1,632,000 1,621,000 1,478,000                      
        convertible notes, net of unamortized discount
      		                       46,228,000 45,794,000 45,049,000 44,097,000 43,180,000 42,297,000 41,447,000 40,629,000 39,842,000               
        internal use software
      		                         226,000                     
        series b convertible preferred shares; 300,000 shares designated as series b; 0 shares issued and outstanding
      		                                              
        series a convertible preferred stock; 300,000 shares designated as series a; 0 shares issued and outstanding at june 30, 2019 and december 31, 2018
      		                                              
        series b convertible preferred stock; 300,000 shares designated as series b; 0 shares issued and outstanding at june 30, 2019 and december 31, 2018
      		                                              
        liabilities and shareholders' equity
      		                                              
        shareholders' equity:
      		                                              
        preferred shares, 0.01 par value...
      		                                              
        series a convertible preferred shares; 300,000 shares designated as series a; 0 shares issued and outstanding at march 31, 2019 and december 31, 2018
      		                                              
        series b convertible preferred shares; 300,000 shares designated as series b; 0 shares issued and outstanding at march 31, 2019 and december 31, 2018
      		                                              
        total shareholders' equity
      		                            177,077,000   157,076,000 170,146,000              
        total liabilities and shareholders' equity
      		                            242,138,000   207,574,000 217,165,000              
        liabilities and shareholders’ equity
      		                                              
        deferred rent and lease obligations
      		                             457,000 438,000 510,000               
        shareholders’ equity:
      		                                              
        series a convertible preferred shares; 300,000 shares designated as series a; 0 and 128,738 shares issued and outstanding at december 31, 2018 and 2017, respectively
      		                                              
        series b convertible preferred shares; 300,000 shares designated as series b; 0 and 126,909 shares issued and outstanding at december 31, 2018 and 2017, respectively
      		                                              
        total shareholders’ equity
      		                             194,037,000 143,620,000                
        total liabilities and shareholders’ equity
      		                             251,313,000 194,981,000                
        accrued research and development costs
      		                              529,000 1,861,000 2,575,000              
        series b convertible preferred shares; 300,000 shares designated as series b; 0 and 126,909 shares issued and outstanding at september 30, 2018 and december 31, 2017, respectively
      		                                              
        series a convertible preferred shares; 300,000 shares designated as series a; 0 and 128,738 shares issued and outstanding at june 30, 2018 and december 31, 2017, respectively
      		                                              
        series b convertible preferred shares; 300,000 shares designated as series b; 0 and 126,909 shares issued and outstanding at june 30, 2018 and december 31, 2017, respectively
      		                                              
        short term investments
      		                                11,561,000              
        convertible notes,net of unamortized discount
      		                                39,084,000              
        deferred rent and lease liability
      		                                598,000              
        series a convertible preferred shares; 300,000 shares designated as series a; 0 and 128,738 shares issued and outstanding at march 31, 2018 and december 31, 2017, respectively
      		                                              
        series b convertible preferred shares; 300,000 shares designated as series b; 0 and 126,909 shares issued and outstanding at march 31, 2018 and december 31, 2017, respectively
      		                                              
        short-term investments
      		                                 21,294,000 53,979,000 81,144,000 89,432,000 96,675,000 54,579,000 59,703,000 43,559,000 31,238,000 29,117,000    
        other assets
      		                                 168,000 168,000 168,000 168,000 168,000 170,000 173,000 170,000 143,000 144,000 2,182,000 2,086,000 1,850,000 
        accounts payable
      		                                 451,000 383,000 368,000 1,902,000 1,592,000 1,777,000 921,000 1,376,000 1,633,000 1,709,000 813,000 1,301,000 1,146,000 
        accrued expenses and other current liabilities
      		                                 2,373,000 2,900,000 2,423,000 2,886,000 4,416,000 3,716,000 3,150,000 3,238,000 2,508,000 1,534,000 1,273,000 1,052,000 992,000 
        accrued interest
      		                                 1,246,000 484,000 1,225,000 480,000 1,204,000 451,000     366,000 104,000  
        2021 convertible notes, net of issuance costs
      		                                 49,541,000 49,390,000 49,242,000 49,099,000 48,960,000 48,820,000        
        other long-term liabilities
      		                                 403,000 423,000 277,000 292,000 307,000 321,000 336,000 351,000 367,000 406,000 24,000 24,000 24,000 
        preferred stock, 0.001 par value: 5,000,000 shares authorized and no shares issued or outstanding
      		                                              
        common stock
      		                                 68,000 272,000 270,000 270,000 270,000 269,000 269,000 264,000 264,000 264,000 163,000   
        liabilities, redeemable convertible preferred stock and stockholders’ equity
      		                                              
        notes payable, current portion
      		                                             3,063,000 
        convertible bridge notes
      		                                              
        convertible bridge notes redemption rights derivative
      		                                              
        notes payable, net of current portion
      		                                             2,550,000 
        warrant liabilities
      		                                             482,000 
        series aa redeemable convertible preferred stock, 0.001 par value...
      		                                             46,253,000 
        series x redeemable convertible preferred stock, 0.001 par value...
      		                                             548,000 
        total redeemable convertible preferred stock
      		                                             46,801,000 
        stockholders’ equity
      		                                              
        other comprehensive loss
      		                                         -11,000     
        total liabilities, redeemable convertible preferred stock and stockholders’ equity
      		                                         113,321,000 120,124,000 51,688,000 55,526,000  
        preferred stock, 0.001 par value: 5,000,000 shares authorized and 0 shares issued or outstanding
      		                                              
        2020 convertible notes, net of debt discount of 12,074
      		                                           8,926,000   
        2020 convertible notes derivative liability
      		                                           8,567,000   
        2020 convertible notes, net of debt discount of 12,333
      		                                            8,667,000  
        2020 convertible notes derivative
      		                                            10,426,000  
        preferred stock. 0.001 par value: 5,000,000 shares authorized and 0 shares issued or outstanding
      		                                              
        liabilities, redeemable convertible preferred stock and stockholders’ deficit
      		                                              
        convertible notes payable
      		                                             1,541,000 
        convertible notes redemption rights derivative
      		                                             480,000 
        stockholders’ deficit:
      		                                              
        total stockholders’ deficit
      		                                             -51,559,000 
        total liabilities, redeemable convertible preferred stock and stockholders’ deficit
      		                                             5,520,000 
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 
                                                     
          operating activities:
        		                                             
          net loss
        		-47,594,000 -42,538,000 -50,332,000 -68,919,000 -61,334,000 -60,327,000 -66,719,000 -69,646,000 -62,054,000 -59,660,000 -61,899,000 -65,701,000 -58,335,000 -66,723,000 -57,756,000 -54,402,000 -42,982,000 -44,247,000 -50,118,000 -34,525,000 -40,179,000 -60,916,000 -29,080,000 -25,040,000 -24,664,000 -19,855,000 -19,284,000 -18,680,000 -19,451,000 -27,319,000 -16,089,000 -15,767,000 -15,343,000 -4,870,000 -7,395,000 -6,562,000 -10,670,000 -12,974,000 -11,128,000 -8,684,000 -10,068,000 -8,172,000 -55,961,000 -2,387,000 -1,462,000 
          adjustments to reconcile net loss to net cash from operating activities:
        		                                             
          depreciation and amortization of property and equipment
        		1,608,000 1,678,000 2,702,000 2,040,000 2,451,000 1,822,000 1,851,000 1,832,000 1,716,000 1,396,000 1,221,000 1,192,000 1,135,000 1,049,000 1,085,000 1,031,000 767,000                             
          amortization of finance lease right of use asset
        		538,000 539,000 538,000 539,000 538,000 539,000 538,000 539,000 538,000 539,000 538,000 539,000 538,000                                 
          stock-based compensation
        		8,493,000 6,112,000 9,759,000 10,857,000 10,331,000 11,088,000 11,248,000 11,332,000 10,252,000 9,930,000 10,316,000 10,245,000 8,915,000 9,693,000 7,677,000 7,369,000 6,270,000 7,037,000 6,989,000 7,311,000 7,900,000 6,070,000 4,047,000 4,489,000 3,961,000         1,548,000 911,000 793,000 784,000 931,000 805,000 687,000 486,000 448,000 374,000 194,000 1,364,000 
          accretion of discount on investments
        		-1,020,000 -1,088,000 -1,599,000 -2,212,000 -2,075,000  -1,849,000 -2,242,000 -2,754,000      155,000 400,000 577,000  744,000     126,000 -63,000 -231,000 -332,000 -256,000 -247,000 -317,000 -366,000               
          changes in operating assets and liabilities:
        		                                             
          prepaid expenses and other assets
        		-1,643,000 1,150,000 739,000 667,000 -467,000 354,000 -286,000 422,000 -1,151,000 4,656,000 -4,660,000 1,832,000 866,000 -2,315,000 -194,000 2,852,000 -3,936,000 291,000 -14,000 1,872,000 -842,000 -102,000 1,107,000 -2,251,000 -271,000 666,000 815,000 -2,091,000 -307,000 -2,016,000 1,162,000   -185,000 342,000 848,000 -45,000 -608,000 -840,000 448,000 52,000 -288,000 -394,000 -303,000 -271,000 
          accounts payable and accrued expenses
        		-5,749,000 -967,000 -12,247,000 8,121,000 -5,258,000 774,000 3,171,000 4,535,000 -2,413,000 15,758,000 -1,134,000 3,273,000 -7,750,000 2,485,000 4,641,000 3,039,000 -491,000 -1,985,000 6,140,000 -16,029,000 7,047,000 9,263,000 4,940,000 -1,256,000 -1,932,000 -4,700,000 4,243,000 -2,181,000 -84,000 3,148,000 1,479,000 3,524,000 -2,261,000             
          operating lease liabilities and right of use assets
        		-29,000 11,000 12,000 10,000 12,000 17,000 22,000 37,000 13,000                                     
          finance lease liability
        		-1,000 2,000 8,000 13,000 12,000 15,000 24,000 29,000 27,000 30,000 35,000 37,000 37,000 38,000 44,000 45,000 45,000 -1,443,000 460,000 1,247,000 -63,000 3,992,000 568,000 846,000 151,000                     
          other liabilities
        		2,000 -1,000 0   -1,877,000 -103,000 -661,000 -1,030,000 1,067,000 -203,000 197,000 -720,000 -14,000                                
          net cash from operating activities
        		-45,394,000 -34,840,000 -50,420,000 -48,964,000 -55,790,000 -46,942,000 -52,103,000 -53,823,000 -56,856,000 -29,339,000 -57,148,000 -50,869,000 -57,560,000 -56,021,000 -43,859,000 -39,039,000 -39,223,000 -30,941,000 -27,413,000 -38,526,000 -24,283,000 -13,109,000 -17,253,000 -22,033,000 -22,245,000 -19,733,000 -10,849,000 -18,104,000 -15,977,000 -20,814,000 -11,635,000 -9,738,000 -11,601,000 -2,988,000 -5,585,000 -5,920,000 -11,619,000 -11,138,000 -9,132,000 -8,003,000 -8,993,000 -7,039,000 -4,327,000 -4,057,000 -1,993,000 
          capital expenditures
        		-93,000 -80,000 54,000 -50,000 -313,000 -389,000 -2,359,000 -1,817,000 -1,112,000 -5,240,000 -4,250,000 -4,648,000 -1,221,000 -3,003,000 839,000 -4,127,000 -320,000 -3,091,000 -3,624,000 -186,000 9,000 -17,824,000 1,830,000 -746,000 -2,411,000 -8,365,000 -3,891,000 -10,221,000 3,632,000 -883,000 -453,000 -109,000 -8,000 0 0 -17,000 -53,000 0 -108,000 -221,000 -15,000 -94,000 -288,000 0 0 
          free cash flows
        		-45,487,000 -34,920,000 -50,366,000 -49,014,000 -56,103,000 -47,331,000 -54,462,000 -55,640,000 -57,968,000 -34,579,000 -61,398,000 -55,517,000 -58,781,000 -59,024,000 -43,020,000 -43,166,000 -39,543,000 -34,032,000 -31,037,000 -38,712,000 -24,274,000 -30,933,000 -15,423,000 -22,779,000 -24,656,000 -28,098,000 -14,740,000 -28,325,000 -12,345,000 -21,697,000 -12,088,000 -9,847,000 -11,609,000 -2,988,000 -5,585,000 -5,937,000 -11,672,000 -11,138,000 -9,240,000 -8,224,000 -9,008,000 -7,133,000 -4,615,000 -4,057,000 -1,993,000 
          investing activities:
        		                                             
          purchases of investments
        		-48,709,000 -54,495,000 -29,438,000 -52,689,000 -139,931,000 -124,045,000 -19,320,000 -38,574,000 -63,947,000 -208,502,000 -13,488,000 -72,896,000 -96,034,000 -198,867,000 -34,437,000 0 -143,023,000 -19,391,000 -67,913,000 -54,756,000 -103,815,000 -77,242,000 -75,665,000 -32,955,000 -23,481,000 -34,052,000 -9,910,000   0 -22,268,000               
          proceeds from maturities of investments
        		66,250,000 91,000,000 123,000,000 84,500,000 82,260,000 86,483,000 99,827,000 96,128,000 101,016,000 72,344,000 66,397,000 108,250,000 62,335,000 50,820,000 58,405,000 81,686,000 81,983,000 38,297,000 53,562,000 105,615,000 74,969,000 37,700,000 15,397,000 31,909,000 56,805,000 66,820,000 51,800,000 20,001,000 29,935,000 20,021,000 20,023,000               
          purchases of property and equipment
        		-93,000 -80,000 54,000 -50,000 -364,000 -309,000 -1,588,000 -1,930,000 -2,035,000 -4,647,000 -4,655,000 -4,119,000 -3,015,000 -3,003,000 -503,000 -2,897,000 -1,955,000 -2,713,000 -3,458,000 -1,121,000 -328,000 -13,653,000 161,000 -1,908,000 -5,207,000 -9,254,000 -6,710,000 -6,545,000 -760,000 -883,000 -453,000 -109,000 -8,000  0 -17,000 -53,000  -108,000 -221,000 -15,000     
          net cash from investing activities
        		17,448,000 36,425,000 93,616,000 31,761,000 -58,035,000 -37,871,000 78,919,000 55,624,000 35,034,000 -140,805,000 48,254,000 31,206,000 -36,721,000 -108,585,000 23,465,000 78,789,000 -62,995,000 16,864,000 -18,189,000 49,352,000 -29,174,000 -54,462,000 -64,193,000 -5,435,000 27,499,000 23,514,000 35,180,000 -126,880,000 29,175,000 19,049,000 -2,985,000 -107,414,000 86,078,000 32,562,000 27,137,000 8,222,000 7,094,000 -42,281,000 4,931,000 -16,366,000 -12,343,000     
          financing activities:
        		                                             
          net cash from financing activities
        		-1,000 0 -67,000   182,849,000 176,000 1,530,000 1,184,000 391,000 189,485,000 182,000 18,343,000 108,440,000 29,526,000 17,246,000 76,000 1,136,000 26,638,000 1,115,000 8,792,000 282,443,000 512,000 151,000 -117,000 92,407,000 31,000   74,835,000 149,000 0 78,518,000  -16,000    48,686,000       
          net change in cash, cash equivalents and restricted cash
        		-27,947,000 1,585,000 43,129,000 -16,988,000 -113,825,000 98,036,000 26,992,000 3,331,000 -20,638,000 -169,753,000 180,591,000 -19,481,000 -75,938,000 -56,166,000 9,132,000 56,996,000 -102,142,000 -12,941,000 -18,964,000 11,941,000 -44,665,000 214,872,000 -80,934,000 -27,317,000 5,137,000 96,188,000 24,362,000 -59,631,000 13,198,000 73,070,000 -14,471,000               
          cash, cash equivalents and restricted cash at beginning of period
        		78,898,000 0 0 0 164,997,000 0 0 0 57,276,000 0 0 0 141,857,000 0 0 0 234,037,000 0 0 0 298,666,000 0 0 0 186,908,000  0 0 112,791,000  0 0 18,349,000             
          cash, cash equivalents and restricted cash at end of period
        		50,951,000 1,585,000 43,129,000 -16,988,000 51,172,000 98,036,000 26,992,000 3,331,000 36,638,000 -169,753,000 180,591,000 -19,481,000 65,919,000 -56,166,000 9,132,000 56,996,000 131,895,000 -12,941,000 -18,964,000 11,941,000 254,001,000 214,872,000 -80,934,000 -27,317,000 192,045,000  24,362,000 -59,631,000 125,989,000  -14,471,000 -117,152,000 171,344,000             
          supplemental disclosure of non-cash financing and investing activities:
        		                                             
          accrued purchases of property and equipment, ending balance
        		    51,000 -80,000 -771,000 113,000 923,000 -593,000 405,000 -529,000 1,794,000                                 
          impairment of operating lease right-of-use asset
        		                                             
          change in fair value of warrant liabilities
        		                                         0 0 0 -267,000 
          issuance of common stock, net of issuance costs
        		         1,000        0    279,889,000 587,000                       
          issuance of common stock pursuant to exercise of stock options
        		                                             
          return of related party short-swing profits
        		 0 0                                           
          repurchase of restricted stock units to satisfy tax withholding
        		 0                                            
          receivables from sale of property and equipment, ending balance
        		                                             
          operating lease liabilities
        		     0 0 0 1,134,000 2,809,000 18,000 5,000 97,000 -24,000 -32,000 -31,000 -33,000 -28,000 -33,000 65,000 -15,000 -25,000 -20,000 358,000 -452,000 -25,000 -22,000 170,000 -210,000                 
          operating lease right-of-use assets
        		                                             
          net unrealized loss on investments
        		 -22,000 98,000 -80,000 -93,000                                         
          operating lease right of use assets
        		                                             
          issuance of common stock, pursuant to exercise of stock options
        		     321,000 176,000 1,530,000 1,184,000 390,000 545,000 182,000 1,114,000 323,000 229,000 3,000 76,000 1,136,000 284,000 1,115,000 8,792,000                         
          investment maturity receivables and purchase payables, ending balance
        		       -576,000 8,648,000                                     
          impairment of acquired intangible asset
        		         0                                    
          write down of property and equipment
        		         20,000    59,000 0 137,000 40,000     357,000 0 -1,000 63,000                     
          accretion of discount and amortization of premium on investments
        		                                             
          cash proceeds from acquisition of business, net of cash paid
        		                                             
          payments made to acquire right of use asset
        		         0 0 -29,000 -7,000     -77,000 43,000   -1,913,000 -3,808,000 -2,201,000 -530,000                     
          treasury stock repurchase
        		                                             
          issuance of common stock, pursuant to sale of treasury stock
        		         0                                    
          issuance of common stock, pursuant to the at-the-market offering program, net of issuance costs
        		         0                                    
          issuance of common stock, pursuant to exercise of warrants
        		         0                                    
          unrealized gain on investments
        		        -454,000    267,000     -64,000 -16,000   -111,000 -160,000 304,000 -95,000 -97,000 -27,000 233,000 38,000                 
          issuance of common stock related to acquisition
        		                                             
          reclassification of construction in process from finance right of use asset
        		                                             
          unrealized loss on investments
        		      431,000    214,000   239,000 169,000 -136,000 -468,000    -33,000                         
          accretion of discount on convertible notes
        		                 1,000 47,000 116,000 589,000 673,000 669,000 572,000 844,000 952,000 917,000 883,000 850,000 818,000 787,000 758,000 696,000             
          expense in connection with warrant issuance
        		                                             
          operating lease liability and right of use asset
        		                                             
          conversion of convertible notes into common stock
        		                                             
          supplemental cash flow information:
        		                                             
          cash paid for interest
        		                 0 -1,199,000 0 1,347,000 0 1,465,000 0 1,495,000 0 1,495,000 0 1,495,000 1,495,000 1,495,000 0 1,495,000 0 1,495,000 0 1,462,000     0 0 0 89,000 
          amortization of premium and accretion of discount on investments
        		          -2,245,000 -2,488,000 -2,343,000                                 
          exercise of warrants
        		           0 7,000                                 
          issuance of common stock pursuant to the at-the-market offering program, net of issuance costs
        		           0 17,222,000 26,000 29,297,000                               
          amortization of right of use asset
        		                535,000                             
          amortization of premium on investments
        		                                             
          changes in operating assets and liabilities, net of acquisition:
        		                                             
          proceeds from sale of treasury stock, net of cash paid
        		                                             
          payment of withholding tax on option exercise
        		                     0 -76,000                       
          convertible notes refinancing costs to the lender
        		                     0 0 -139,000 -98,000                     
          finance lease right of use asset and lease liability
        		                     0 0 0 20,179,000                     
          right of use asset
        		              535,000                               
          accrued purchases of property and equipment
        		              1,342,000 -1,230,000 1,635,000 -378,000 -166,000 935,000 337,000 -4,171,000 1,669,000 1,162,000 2,796,000 889,000 2,819,000 -3,676,000 4,392,000                 
          unrealized loss on marketable securities
        		                                             
          other long term liabilities
        		               -14,000 -15,000 -14,000 -13,000 -15,000 -14,000                         
          reclassification of construction in process to finance right of use asset
        		                 59,000   325,000                         
          expense in connection with warrant issuances
        		                                             
          accretion of discount (amortization of premium) on investments
        		                    620,000 274,000                        
          common stock repurchase
        		                     0 0 0 -72,000  0                   
          proceeds from sale of treasury stock
        		                     0 0 538,000 53,000                     
          payment of withholding tax on option exercises
        		                                             
          retirement of treasury stock
        		                        72,000 0 -2,000 0 1,395,000                 
          treasury stock purchases paid in prior year
        		                                             
          withholding tax payable on shares withheld in treasury stock
        		                                             
          conversion of 2021 and 2022 convertible notes into common stock
        		                 81,387,000                            
          cash paid for income taxes
        		                             0                
          depreciation and amortization expense
        		                  808,000 706,000 674,000 630,000 273,000                       
          purchases of internal use software
        		                  -423,000    -278,000 -280,000 -88,000                     
          proceeds from exercise of options
        		                             -1,000                
          accrued purchases of internal use software
        		                  -96,000 -189,000 311,000 200,000 -22,000 -52,000 174,000                     
          reclassification of construction in process (from) to finance right of use asset
        		                                             
          witholding tax payable on shares witheld in treasury stock
        		                        429,000                     
          expense in connection with warrant issue
        		                                             
          loss on disposal of property and equipment
        		                             5,000 107,000               
          cash acquired in connection with the reverse merger
        		                             0 0 0 76,348,000             
          proceeds from sale of property and equipment
        		                             0 0 0 20,000             
          payment of security deposit
        		                             -89,000                
          conversion of convertible preferred stock into common stock
        		                             0 0 0 41,466,000             
          net exercise of options
        		                          0                   
          reclassification of construction in process of finance right of use asset
        		                      0 0 26,465,000                     
          increase in lease liability
        		                                             
          depreciation expense
        		                        118,000 101,000 121,000 102,000 102,000 97,000 76,000 74,000 83,000             
          proceeds from issuance of common stock, net of issuance costs
        		                         91,680,000 0   75,504,000 0 0 78,518,000             
          payment of witholding tax on option exercise
        		                                             
          cash, cash equivalents and restricted cash at beginning of year
        		                                             
          cash, cash equivalents and restricted cash at end of year
        		                                             
          stock-based compensation expense
        		                          2,693,000                   
          amortization of operating lease right-of-use assets
        		                            190,000                 
          share-based compensation expense
        		                            3,180,000 2,821,000 2,612,000 2,786,000 5,382,000             
          amortization of premium on short term investments
        		                                12,000             
          series a preferred shares issued for services
        		                                             
          deferred rent
        		                                             
          proceeds from issuance of series a convertible preferred shares net
        		                                             
          proceeds from issuance of series b convertible preferred shares net
        		                                             
          payments from related party payable
        		                                             
          payment to acquire treasury stock
        		                                             
          (increase in) / reduction of lease liability
        		                              -71,000               
          accrued research and development costs
        		                              -1,332,000 -714,000 116,000             
          proceeds from issuance of convertible preferred stock
        		                                             
          supplemental disclosure of non-cash financing activities:
        		                                             
          reduction of lease liability
        		                                -20,000             
          prepaid expenses
        		                                -266,000             
          proceeds from maturities of short term investments
        		                                9,718,000             
          net change in cash and restricted cash
        		                                152,995,000             
          cash flows from operating activities:
        		                                             
          adjustments to reconcile net loss to cash from operating activities:
        		                                             
          noncash interest expense
        		                                 151,000 148,000 143,000 139,000 140,000    0 555,000 303,000 274,000 
          noncash rent
        		                                 -14,000            
          noncash asset impairment charge
        		                                 14,000            
          amortization of premium on marketable securities
        		                                 33,000 51,000 62,000 71,000 61,000 52,000 69,000 43,000     
          depreciation
        		                                 38,000 38,000 63,000 61,000 58,000 39,000 35,000 37,000 38,000 6,000   
          accounts payable
        		                                 68,000 15,000 -1,534,000 310,000 -185,000 856,000 -455,000 -257,000 -76,000 896,000 -487,000 154,000 
          accrued expenses and other liabilities
        		                                 229,000            
          cash flows from investing activities:
        		                                             
          purchases of short-term investments
        		                                 0 0 -14,482,000 -12,722,000 -53,207,000 -11,656,000 -33,253,000 -24,161,000     
          proceeds from the maturities of short-term investments
        		                                 32,562,000 27,137,000 22,721,000 19,869,000 11,069,000 16,695,000 17,108,000 11,833,000     
          purchase of property and equipment
        		                                         -94,000 -288,000   
          cash flows from financing activities:
        		                                             
          proceeds from issuance of 2021 convertible notes
        		                                     0        
          payments of 2021 convertible notes issuance costs
        		                                     0        
          net proceeds from issuance of common stock
        		                                     0 -52,000       
          proceeds from the issuance of common stock pursuant to stock option plans
        		                                             
          proceeds from the issuance of common stock pursuant to employee stock purchase plan
        		                                             
          payments made for taxes of employees who surrendered shares related to settlement of restricted stock
        		                                             
          net cash from financing activities:
        		                                           -40,000 51,514,000 
          net change in cash and cash equivalents
        		                                 29,574,000 21,536,000 2,337,000 -4,525,000 -53,206,000 44,485,000 -20,187,000 -21,336,000 -9,206,000 40,236,000 -4,127,000 49,521,000 
          cash and cash equivalents, beginning of period
        		                                 0 0 0 29,798,000 0 0 0 80,042,000 0 0 0 3,618,000 
          cash and cash equivalents, end of period
        		                                 29,574,000 21,536,000 2,337,000 25,273,000 -53,206,000 44,485,000 -20,187,000 58,706,000 -9,206,000 40,236,000 -4,127,000 53,139,000 
          supplemental disclosure of cash flow information:
        		                                             
          supplemental disclosure of noncash investing and financing activities:
        		                                             
          net unrealized gain on marketable securities
        		                                 9,000 47,000 0 -18,000  -15,000 17,000 11,000     
          proceeds from issuance of common stock pursuant to stock option plans
        		                                      0       
          proceeds from issuance of common stock pursuant to employee stock purchase plan
        		                                  0    0       
          payments made for taxes of employees who surrendered shares related to unrestricted stock
        		                                             
          noncash rent expense
        		                                   -15,000 -15,000 -14,000        
          accrued expenses and other current liabilities
        		                                   282,000 -2,254,000 1,453,000 1,017,000 -88,000 730,000 951,000 -164,000 481,000 170,000 
          loss on extinguishment of debt
        		                                         0 3,717,000 0 522,000 
          change in fair value of convertible bridge notes redemption rights derivative
        		                                         0 0 0 -480,000 
          change in fair value of 2020 convertible notes derivative liability
        		                                         0 46,649,000   
          net proceeds from issuance of common stock in initial public offering
        		                                             
          proceeds from issuance of 2020 convertible notes in initial public offering
        		                                         0   21,000,000 
          payments of 2020 convertible notes issuance costs
        		                                         0 0 0 -1,841,000 
          proceeds from the issuance of common stock pursuant to stock option plan
        		                                             
          principal payments on notes payable
        		                                         0 0   
          acquisition of leasehold improvements
        		                                         0    
          conversion of series aa preferred stock into common stock upon initial public offering
        		                                         1,000 0 0 46,383,000 
          conversion of series x preferred stock into common stock upon initial public offering
        		                                         0 0 0 548,000 
          conversion of convertible bridge notes into common stock upon initial public offering
        		                                         -1,000 0 0 2,028,000 
          conversion of 2020 convertible notes into common stock
        		                                         1,000    
          accretion of series aa preferred stock to redemption value
        		                                         1,000 0 0 130,000 
          reclassification of fair value of warrant liability to equity upon initial public offering
        		                                         0 0 0 215,000 
          reclassification of deferred public offering costs to stockholders’ equity
        		                                         0 0   
          reclassification of deferred public offering costs to other assets
        		                                         0 0 0 256,000 
          net unrealized loss on marketable securities
        		                                             
          reclassification of deferred public offering costs to stockholders' equity
        		                                             
          deferred rent and lease incentives
        		                                       -15,000 -16,000     
          adjustments to reconcile net loss to cash used by operating activities:
        		                                             
          purchase of short-term investments
        		                                         -4,576,000    
          net cash from investing activities:
        		                                             
          net proceeds from issuance of convertible notes
        		                                             
          net proceeds from issuance of common stock in follow-on public offering
        		                                             
          proceeds from the issuance of shares pursuant to stock option plans
        		                                             
          proceeds from the issuance of shares pursuant to employee stock purchase plan
        		                                             
          proceeds from exercise of warrants for series aa preferred stock
        		                                             
          accrual of series aa preferred stock dividends
        		                                             
          reclassification of fair value of warrant liability related to exercise of preferred stock warrants
        		                                             
          unrealized comprehensive loss on marketable securities
        		                                             
          proceeds from issuance of common stock in initial public offering, net of issuance costs
        		                                          -30,000 -40,000 38,155,000 
          proceeds from issuance of common stock in follow-on public offering, net of issuance costs
        		                                             
          proceeds from exercise of stock options
        		                                             
          proceeds from issuance of 2020 convertible notes in initial public offering, net of underwriting discounts
        		                                             
          change in fair value of 2020 convertible notes derivative
        		                                            -1,997,000 
          principal and termination payments on notes payable
        		                                            -5,800,000 
          reclassification of deferred public offering costs to stockholders’s equity
        		                                            1,590,000 
          change in fair value of warrant liabilities and convertible notes redemption rights derivative
        		                                             
          net proceeds from issuance of notes payable and series aa preferred stock warrants
        		                                             
          net proceeds from issuance of series aa preferred stock and series aa preferred stock warrants
        		                                             
          issuance of 2,677,731 shares of series aa preferred stock upon conversion of convertible notes and accrued interest
        		                                             
          conversion of series aa preferred stock to common stock