7Baggers

RAPT Therapeutics, Inc
(NASDAQ:RAPT) 

RAPT stock logo

RAPT Therapeutics, Inc., a clinical-stage immunology-based biopharmaceutical company, focuses on discovering, developing, and commercializing oral small molecule therapies for patients with unmet needs in oncology and inflammatory diseases. Its lead oncology drug candidate is FLX475, an oral small m...

Founded: 2015
Full Time Employees: 71
CEO: Brian Russell Wong  
Sector: Healthcare
Industry: Biotechnology
Pharmaceuticals
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At a glance:
Bull Thesis:
Bear Thesis:
Main Competitors:
Moat:
Income Statements:
Quarterly
Annual
    Unit: USD2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 
                             
      operating expenses:
    		                         
      research and development
    		12,034,000 12,340,000 12,042,000 46,456,000 13,340,000 22,640,000 24,781,000 26,764,000 27,022,000 21,642,000 25,574,000 19,454,000 16,599,000 14,359,000 16,670,000 14,299,000 15,725,000 13,190,000 13,771,000 10,904,000 12,912,000 10,986,000 10,683,000 10,190,000 8,582,000 
      general and administrative
    		7,337,000 7,195,000 7,223,000 8,009,000 6,448,000 6,690,000 7,737,000 6,453,000 6,897,000 6,722,000 5,988,000 4,977,000 5,079,000 5,436,000 4,748,000 4,491,000 3,774,000 3,760,000 4,012,000 3,483,000 3,197,000 2,802,000 3,289,000 2,625,000 1,733,000 
      total operating expenses
    		19,371,000 19,535,000 19,265,000 54,465,000 19,788,000 29,330,000 32,518,000 33,217,000 33,919,000 28,364,000 31,562,000 24,431,000 21,678,000 19,795,000 21,418,000 18,790,000 19,499,000 16,950,000 17,783,000 14,387,000 16,109,000 13,788,000 13,972,000 12,815,000 10,315,000 
      income from operations
    		-19,371,000 -19,535,000 -19,265,000 -54,465,000 -19,788,000 -29,330,000 -32,518,000 -33,217,000 -33,919,000 -28,364,000 -31,562,000 -24,431,000 -21,678,000 -18,909,000 -20,777,000 -18,034,000 -18,533,000 -16,081,000 -16,561,000 -13,085,000 -14,581,000 -12,511,000 -13,037,000 12,815,000 10,315,000 
      yoy
    		-2.11% -33.40% -40.76% 63.97% -41.66% 3.41% 3.03% 35.96% 56.47% 50.00% 51.91% 35.47% 16.97% 17.59% 25.46% 37.82% 27.10% 28.53% 27.03% -202.11% -241.36%     
      qoq
    		-0.84% 1.40% -64.63% 175.24% -32.53% -9.80% -2.10% -2.07% 19.58% -10.13% 29.19% 12.70% 14.64% -8.99% 15.21% -2.69% 15.25% -2.90% 26.56% -10.26% 16.55% -4.03% -201.73% 24.24%  
      operating margin %
    		-Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% NaN% NaN% NaN% -Infinity% NaN% -2134.20% -3241.34% -2385.45% -1918.53% -1850.52% -1355.24% -1004.99% -954.25% -979.72% -1394.33% Infinity% Infinity% 
      other income
    		1,791,000 1,892,000 2,100,000 1,216,000 1,356,000 1,667,000 1,997,000 2,341,000 2,548,000 3,084,000 2,291,000 1,480,000 443,000 -275,000 309,000 105,000 -118,000 -29,000 47,000 549,000 237,000 391,000 135,000 259,000 344,000 
      net income
    		-17,580,000 -17,643,000 -17,165,000 -53,249,000 -18,432,000 -27,663,000 -30,521,000 -30,876,000 -31,371,000 -25,280,000 -29,271,000 -22,951,000 -21,235,000 -19,184,000 -20,468,000 -17,929,000 -18,651,000 -16,110,000 -16,514,000 -12,735,000 -14,631,000 -12,387,000 -13,139,000 72,778,000 -9,971,000 
      yoy
    		-4.62% -36.22% -43.76% 72.46% -41.25% 9.43% 4.27% 34.53% 47.73% 31.78% 43.01% 28.01% 13.85% 19.08% 23.94% 40.79% 27.48% 30.06% 25.69% -117.50% 46.74%     
      qoq
    		-0.36% 2.78% -67.76% 188.89% -33.37% -9.36% -1.15% -1.58% 24.09% -13.63% 27.54% 8.08% 10.69% -6.27% 14.16% -3.87% 15.77% -2.45% 29.67% -12.96% 18.12% -5.72% -118.05% -829.90%  
      net income margin %
    		-Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% NaN% NaN% NaN% -Infinity% NaN% -2165.24% -3193.14% -2371.56% -1930.75% -1853.86% -1351.39% -978.11% -957.53% -970.01% -1405.24% Infinity% -Infinity% 
      other comprehensive income:
    		                         
      unrealized gain on marketable securities
    		84,000   -57,000 154,000 -37,000 -113,000 224,000 59,000 136,000 365,000 -240,500 -74,000   -228,000 9,000 -18,000 -50,000 -67,000 -33,000 369,000    
      total comprehensive loss
    		-17,496,000 -17,662,000 -17,180,000 -53,306,000 -18,278,000 -27,700,000 -30,634,000 -30,652,000 -31,312,000 -25,799,000 -28,906,000 -22,524,000 -20,943,000 -18,812,000 -21,379,000 -18,180,000 -18,469,000 -16,058,000 -16,526,000 -12,986,000 -14,734,000 -12,217,000 -13,152,000 72,737,000 -9,956,000 
      net income per share
    		-0.65 -0.65 -0.08 -1.22 -0.47 -0.71 -0.79 -0.81 -0.82 -0.66 -0.76 -0.65 -0.63 -0.62 -0.69 -0.61 -0.63 -0.63 -0.66 -0.52 -0.6 -0.51 -0.56 50.04 -12.41 
      weighted-average number of shares used in computing net loss per share, basic and diluted
    		26,963,107 26,949,752 215,410,253 40,761,143 38,903,476 38,866,760 38,625,365 38,338,161 38,358,032 38,328,741 38,280,539 32,540,406 33,684,261 31,140,323 29,572,467 27,390,326 29,491,857 25,589,947 24,844,946 24,134,305 24,449,115 24,336,102 23,266,063 4,346,400 803,229 
      other comprehensive loss:
    		                         
      unrealized loss on marketable securities
    		 -19,000 -15,000           -178,000 -710,000        -217,000   
      foreign currency translation loss
    		                         
      revenue
    		             886,000 641,000 756,000 966,000 869,000 1,222,000 1,302,000 1,528,000 1,277,000 935,000   
      yoy
    		        NaN% NaN% NaN%  NaN% 1.96% -47.55% -41.94% -36.78% -31.95% 30.70%       
      qoq
    		        NaN% NaN%   NaN% 38.22% -15.21% -21.74% 11.16% -28.89% -6.14% -14.79% 19.66% 36.58%    
      foreign currency translation gain
    		         -655,000  -88,000 366,000 550,000 -201,000           
      net loss before taxes
    		               -17,929,000 -18,651,000 -16,110,000 -16,514,000 -12,536,000 -14,344,000 -12,120,000 -12,902,000   
      provision for income taxes
    		                   199,000 287,000 267,000 237,000   
      foreign currency translation adjustment
    		               70,250 173,000 70,000 38,000 -184,000 -70,000 -199,000 204,000   
      other income:
    		                         
      other comprehensive income
    		                       4,250 15,000 
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 
                               
        assets
      		                         
        current assets:
      		                         
        cash and cash equivalents
      		37,930,000 41,886,000 60,257,000 169,735,000 37,900,000 37,077,000 45,317,000 47,478,000 54,135,000 50,164,000 45,768,000 38,946,000 27,706,000 57,203,000 32,418,000 24,027,000 59,999,000 86,220,000 24,720,000 24,918,000 20,229,000 28,957,000 91,529,000 77,383,000 48,310,000 
        marketable securities
      		119,414,000 127,061,000 119,019,000 61,320,000 60,005,000 77,761,000 96,262,000 111,384,000 130,642,000 154,834,000 185,861,000 210,122,000 167,730,000 150,138,000 140,590,000 165,627,000 150,787,000 137,084,000 73,686,000 86,592,000 102,557,000 103,993,000 46,670,000   
        prepaid expenses and other current assets
      		3,701,000 3,912,000 3,920,000 4,181,000 4,693,000 5,658,000 6,781,000 2,920,000 2,361,000 2,419,000 2,958,000 3,626,000 2,458,000 2,588,000 2,656,000 3,319,000 3,709,000 4,651,000 4,200,000 4,088,000 2,722,000 3,127,000 3,685,000 3,123,000 2,914,000 
        total current assets
      		161,045,000 172,859,000 183,196,000 235,236,000 102,598,000 120,496,000 148,360,000 161,782,000 187,138,000 207,417,000 234,587,000 252,694,000 197,894,000 209,929,000 175,664,000 192,973,000 214,495,000 227,955,000 102,606,000 115,598,000 125,508,000 136,077,000 146,894,000 80,506,000 51,224,000 
        property and equipment
      		765,000 970,000 1,158,000 1,367,000 1,653,000 1,933,000 2,239,000 2,448,000 2,704,000 2,963,000 2,999,000 2,539,000 2,742,000 2,921,000 2,629,000 2,741,000 2,578,000 2,737,000 2,929,000 2,982,000 3,073,000 3,210,000 3,606,000 3,707,000 4,002,000 
        operating lease right-of-use assets
      		1,883,000 2,308,000 2,827,000 3,333,000 3,825,000 4,304,000 4,772,000 5,228,000 5,672,000 6,103,000 6,526,000 6,940,000 5,782,000 6,055,000 6,322,000           
        other assets
      		2,046,000 2,273,000 389,000 389,000 389,000 447,000 447,000 3,871,000 4,207,000 4,273,000 4,214,000 4,036,000 3,071,000 3,091,000 2,933,000 2,922,000 389,000 389,000 389,000 389,000 389,000 389,000 389,000 389,000 3,143,000 
        total assets
      		165,739,000 178,410,000 187,570,000 240,325,000 108,465,000 127,180,000 155,818,000 173,329,000 199,721,000 220,756,000 248,326,000 266,209,000 209,489,000 221,996,000 187,548,000 198,636,000 217,462,000 231,081,000 105,924,000 118,969,000 128,970,000 139,676,000 150,889,000 84,602,000 58,369,000 
        liabilities and stockholders' equity
      		                         
        current liabilities:
      		                         
        accounts payable
      		2,102,000 4,189,000 1,295,000 1,275,000 1,380,000 2,716,000 6,771,000 5,176,000 5,297,000 2,690,000 8,941,000 3,365,000 4,043,000 4,097,000 1,936,000 1,999,000 4,017,000 2,714,000 3,131,000 2,383,000 4,405,000 2,381,000 3,409,000 1,143,000 1,590,000 
        accrued expenses
      		9,008,000 6,583,000 4,928,000 9,597,000 6,398,000 9,487,000 11,807,000 14,103,000 14,109,000 10,295,000 10,348,000 8,656,000 8,240,000 7,507,000 8,276,000 6,326,000 6,845,000 5,068,000 4,539,000 4,935,000 5,669,000 4,256,000 3,832,000 3,642,000 3,410,000 
        license fees payable
      		   35,000,000                      
        operating lease liabilities, current
      		2,209,000 2,205,000 2,315,000 2,422,000 2,523,000 2,568,000 2,508,000 2,448,000 2,390,000 2,333,000 2,278,000 2,171,000 1,551,000 1,503,000 1,481,000           
        other current liabilities
      		56,000 66,000 140,000 57,000 61,000 30,000 82,000 109,000 53,000 96,000 41,000 32,000 33,000 39,000 22,000 254,000 295,000 329,000 338,000 328,000 389,000 430,000 436,000 471,000 457,000 
        total current liabilities
      		13,375,000 13,043,000 8,678,000 48,351,000 10,362,000 14,801,000 21,168,000 21,836,000 21,849,000 15,414,000 21,608,000 14,224,000 13,867,000 13,146,000 12,360,000 9,595,000 12,695,000 10,394,000 11,143,000 11,742,000 15,591,000 13,080,000 13,442,000 9,256,000 5,457,000 
        operating lease liabilities, non-current
      		387,000 959,000 1,520,000 2,070,000 2,597,000 3,159,000 3,815,000 4,458,000 5,072,000 5,665,000 6,248,000 6,819,000 6,316,000 6,717,000 7,112,000           
        total liabilities
      		13,762,000 14,002,000 10,198,000 50,421,000 12,959,000 17,960,000 24,983,000 26,294,000 26,921,000 21,079,000 27,856,000 21,043,000 20,183,000 19,863,000 19,713,000 12,256,000 15,589,000 13,502,000 14,283,000 14,790,000      
        commitments and contingencies
      		                         
        stockholders' equity:
      		                         
        preferred stock
      		                         
        common stock
      		2,000 13,000 13,000  3,000 3,000 3,000  3,000 3,000 3,000  3,000 3,000 3,000  3,000 3,000 2,000  2,000 2,000 2,000  1,000 
        additional paid-in capital
      		818,810,000 813,734,000 809,036,000 804,388,000 656,694,000 652,130,000 646,045,000 631,611,000 626,724,000 622,289,000 617,283,000 613,073,000 534,689,000 526,573,000 473,463,000 470,629,000 467,942,000 465,179,000 323,184,000 319,196,000 312,078,000 309,908,000 307,009,000 235,049,000 23,923,000 
        accumulated other comprehensive income
      		100,000 16,000 35,000 50,000       339,000      45,000   -177,000 74,000 177,000 7,000 20,000 13,000 
        accumulated deficit
      		-666,935,000 -649,355,000 -631,712,000 -614,547,000 -561,298,000 -542,866,000 -515,203,000 -484,682,000 -453,806,000 -422,435,000 -397,155,000 -367,884,000 -344,933,000 -323,698,000 -304,514,000 -284,046,000 -266,117,000 -247,466,000 -231,356,000 -214,842,000 -202,107,000 -187,476,000 -175,089,000 -161,950,000 -148,734,000 
        total stockholders' equity
      		151,977,000 164,408,000 177,372,000 189,904,000 95,506,000 109,220,000 130,835,000 147,035,000 172,800,000 199,677,000 220,470,000 245,166,000 189,306,000 202,133,000 167,835,000 186,380,000 201,873,000 217,579,000 91,641,000 104,179,000 110,047,000 122,611,000 131,929,000 73,121,000  
        total liabilities and stockholders' equity
      		165,739,000 178,410,000 187,570,000 240,325,000 108,465,000 127,180,000 155,818,000 173,329,000 199,721,000 220,756,000 248,326,000 266,209,000 209,489,000 221,996,000 187,548,000 198,636,000 217,462,000 231,081,000 105,924,000 118,969,000 128,970,000 139,676,000 150,889,000   
        commitments
      		                         
        preferred stock, 0.0001 par value: 50,000,000 shares authorized; no shares issued and outstanding at december 31, 2024 and 2023
      		                         
        common stock, 0.0001 par value...
      		   13,000    3,000    3,000    3,000    2,000    2,000  
        accumulated other comprehensive gain
      		    107,000 -47,000 -10,000 103,000                  
        preferred stock, 0.0001 par value: 50,000,000 shares authorized; no shares issued and outstanding at december 31, 2023 and 2022
      		                         
        accumulated other comprehensive loss
      		        -121,000 -180,000  -26,000 -453,000 -745,000 -1,117,000 -206,000  -137,000 -189,000       
        deferred revenue, current
      		              645,000 1,016,000 1,538,000 2,283,000 3,135,000 4,096,000 5,128,000 6,013,000 5,765,000 4,000,000  
        deferred revenue, non-current
      		              241,000  745,000 967,000 983,000  1,132,000 1,775,000 3,300,000   
        deferred rent, net of current portion
      		               2,150,000 2,149,000 2,141,000 2,157,000 2,185,000 2,200,000 2,210,000 2,218,000 2,225,000 2,219,000 
        preferred stock, 0.0001 par value: 50,000,000 shares authorized; no shares issued and outstanding at december 31, 2022 and 2021
      		                         
        deferred revenue, net of current portion
      		               511,000    863,000      
        preferred stock, 0.0001 par value: 50,000,000 shares authorized; no shares issued and outstanding at december 31, 2021 and 2020
      		                         
        preferred stock, 0.0001 par value: 50,000,000 shares authorized; no shares issued and outstanding at december 31, 2020 and 2019
      		                         
        accounts receivable
      		                      5,010,000   
        liabilities, convertible preferred stock and stockholders' equity
      		                         
        convertible preferred stock
      		                        175,490,000 
        stockholders' equity
      		                         
        preferred stock, 0.0001 par value: 50,000,000 shares authorized; no shares issued and outstanding at december 31, 2019 and 2018
      		                         
        related party promissory note for the purchase of common stock
      		                         
        total liabilities, convertible preferred stock and stockholders' equity
      		                       84,602,000  
        liabilities, convertible preferred stock and stockholders' deficit
      		                         
        total stockholders' (deficit) equity
      		                        -124,797,000 
        total liabilities, convertible preferred stock and stockholders'
      		                        58,369,000 
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 
                                
          operating activities
        		                        
          net loss
        		-17,580,000 -17,643,000 -17,165,000 -53,249,000 -18,432,000 -27,663,000 -30,521,000 -30,876,000 -31,371,000 -25,280,000 -29,271,000 -22,951,000 -21,235,000 -19,184,000 -20,468,000 -17,929,000 -18,651,000 -16,110,000 -16,514,000 -12,735,000 -14,631,000 -12,387,000 -13,139,000 -13,216,000 
          adjustments to reconcile net loss to net cash from operating activities:
        		                        
          accretion of discounts on marketable securities
        		-735,000 -840,000 -693,000 -530,000 -552,000 -748,000 -983,000                  
          depreciation and amortization
        		205,000 228,000 252,000 287,000 297,000 305,000 314,000 323,000 325,000 269,000 299,000 252,000 260,000 274,000 261,000 231,000 229,000 256,000 280,000 265,000 263,000 396,000 199,000 319,000 
          stock-based compensation expense
        		5,029,000 4,537,000 4,648,000 4,589,000 4,564,000 5,384,000 5,398,000 4,429,000 4,329,000 4,239,000 4,094,000 3,025,000 2,865,000 2,672,000 2,702,000 2,086,000 2,291,000 2,888,000 2,687,000 2,558,000 2,005,000 2,035,000 2,088,000 896,000 
          non-cash operating lease expense
        		478,000 584,000 584,000 584,000 584,000 584,000 584,000 584,000 583,000 584,000 584,000 478,000 428,000 426,000 428,000          
          changes in operating assets and liabilities:
        		                        
          prepaid expenses and other assets
        		438,000 -1,876,000 261,000 512,000 1,023,000 1,123,000 -437,000 -223,000 124,000 480,000 490,000              
          accounts payable, accrued expenses and other current liabilities
        		328,000 4,475,000 -4,566,000 3,090,000 -4,394,000 -6,427,000 -728,000 -71,000 6,378,000 -6,249,000 7,277,000  673,000 1,409,000 1,891,000          
          license fees payable
        		0 0 -35,000,000                      
          operating lease liabilities
        		-621,000 -736,000 -735,000 -720,000 -712,000 -712,000 -711,000 -696,000 -688,000 -689,000 -634,000 -514,000 -508,000 -532,000 -543,000          
          net cash from operating activities
        		-12,458,000 -11,271,000 -52,414,000 -10,437,000 -17,622,000 -28,154,000 -27,084,000 -27,754,000 -21,884,000 -28,808,000 -18,602,000 -22,849,000 -17,149,000 -15,195,000 -15,578,000 -20,681,000 -12,519,000 -13,916,000 -13,910,000 -15,366,000 -9,953,000 -6,427,000 -8,745,000 -5,688,000 
          capital expenditures
        		0 -40,000 -43,000 -1,000 -17,000 1,000 -105,000 -67,000 -66,000 -233,000 -759,000 -49,000 -81,000 -566,000 -149,000 -394,000 -70,000 -64,000 -227,000 -174,000 -126,000 0 -98,000 -25,000 
          free cash flows
        		-12,458,000 -11,311,000 -52,457,000 -10,438,000 -17,639,000 -28,153,000 -27,189,000 -27,821,000 -21,950,000 -29,041,000 -19,361,000 -22,898,000 -17,230,000 -15,761,000 -15,727,000 -21,075,000 -12,589,000 -13,980,000 -14,137,000 -15,540,000 -10,079,000 -6,427,000 -8,843,000 -5,713,000 
          investing activities
        		                        
          purchase of marketable securities
        		-47,743,000 -48,891,000 -89,761,000 -30,802,000 -17,409,000 -17,193,000 -16,814,000 -55,259,000 -32,287,000 -36,073,000 -37,878,000 -78,138,000 -40,477,000 -66,186,000 -6,055,000 -16,927,000 -29,345,000 -102,971,000 -15,734,000 -16,628,000 -10,814,000 -65,009,000 -46,883,000  
          proceeds from maturities of marketable securities
        		56,209,000 41,670,000 32,740,000 29,960,000 35,871,000 36,405,000 32,806,000 75,965,000 58,102,000 68,743,000 63,945,000 36,917,000 22,959,000 56,294,000 30,041,000 1,429,000 15,241,000 39,343,000 28,372,000 32,297,000 12,000,000    
          purchase of property and equipment
        		0 -40,000 -43,000 -1,000 -17,000 1,000 -105,000 -67,000 -66,000 -233,000 -759,000 -49,000 -81,000 -566,000 -149,000 -394,000 -70,000 -64,000 -227,000 -174,000 -126,000 0 -98,000 -25,000 
          net cash from investing activities
        		8,466,000 -7,261,000 -57,064,000 -843,000 18,445,000 19,213,000 15,887,000 20,639,000 25,749,000 32,437,000 25,308,000 -41,270,000 -17,599,000 -10,458,000 23,837,000 -15,892,000 -14,174,000 -63,692,000 12,411,000 15,495,000 1,060,000 -57,009,000 -46,981,000 20,000 
          financing activities
        		                        
          proceeds from issuances of common stock in “at-the-market” offerings, net of issuance costs
        		   -12,000 0 0 8,969,000                  
          proceeds from issuance of common stock under employee stock plans
        		36,000   77,000 0 701,000 67,000 458,000 106,000 767,000 116,000  272,000 654,000 132,000          
          net cash from financing activities
        		36,000   143,115,000 0 701,000 9,036,000 458,000 106,000 767,000 116,000 75,359,000 5,251,000 50,438,000 132,000 601,000 472,000 139,108,000 1,301,000 4,560,000 165,000 864,000 69,872,000 34,741,000 
          net decrease in cash and cash equivalents
        		-3,956,000 -18,371,000 -109,478,000                  -8,728,000    
          cash and cash equivalents at beginning of period
        		0 0 169,735,000 0 0 0 47,478,000 0 0 0 38,946,000  0 0 24,027,000  0 0 24,918,000  0 0 77,383,000  
          cash and cash equivalents at end of period
        		-3,956,000 -18,371,000 60,257,000 131,835,000 823,000 -8,240,000 45,317,000 -6,657,000 3,971,000 4,396,000 45,768,000  -29,497,000 24,785,000 32,418,000  -26,221,000 61,500,000 24,720,000  -8,728,000 -62,572,000 91,529,000  
          loss on foreign currency translation
        		                        
          proceeds from sale of common stock and pre-funded warrants in a private placement, net of issuance costs
        		                        
          net increase in cash and cash equivalents
        		   131,835,000 823,000 -8,240,000 -2,161,000 -6,657,000 3,971,000 4,396,000 6,822,000 11,240,000 -29,497,000 24,785,000 8,391,000 -35,972,000 -26,221,000 61,500,000 -198,000    14,146,000 29,073,000 
          gain on foreign currency translation
        		       0 0   -88,000 366,000 550,000 -201,000 -23,000 173,000 70,000 38,000 -184,000 -70,000 -199,000 204,000  
          deferred revenue
        		           0 0 -886,000 -641,000 -756,000 -967,000 -868,000 -841,000 -1,301,000 -1,528,000 -1,277,000 5,065,000  
          proceeds from equity offerings, net of issuance costs
        		           75,026,000 0            
          proceeds from issuances of common stock in “at the market” offerings, net of issuance costs
        		                0        
          supplemental disclosures of non-cash investing information
        		                        
          right-of-use asset obtained in exchange for lease obligation
        		           14,648,000 0 0 -6,585,000          
          (accretion of discounts) amortization of premium on marketable securities
        		        -1,564,000 -1,507,000 -1,441,000              
          supplemental disclosures of non-cash information
        		                        
          amortization of premium (accretion of discounts) on marketable securities
        		                        
          prepaid expenses and other current assets
        		           -2,133,000 150,000 -90,000 652,000 -2,143,000 942,000 -451,000 -112,000      
          accounts payable, accrued expenses, and other current liabilities
        		                 109,000 362,000      
          deferred rent, net of current portion
        		                        
          proceeds from sale of equipment
        		                        
          proceeds from issuances of common stock in "at the market" offerings, net of issuance costs
        		                        
          proceeds from issuances of common stock under employee stock plans
        		                        
          cash and cash equivalents at beginning of year
        		                        
          cash and cash equivalents at end of year
        		                        
          supplemental disclosures of non-cash investing and financing information
        		                        
          amortization of premium on marketable securities
        		            -148,000 166,000 341,000 430,000 410,000   229,000 217,000    
          deferred rent
        		                -26,000 -22,000 -28,000  -10,000 -8,000 -7,000  
          issuance costs related to public offering included in accrued expenses
        		                -33,000        
          loss on disposal of capital equipment
        		                       -44,000 
          proceeds from public offerings, net of issuance costs
        		                        
          supplemental disclosures of cash flow information:
        		                        
          cash paid for income taxes
        		                        
          offering costs included in accounts payable and accrued expenses
        		                        
          proceeds from public offering, net of issuance costs
        		                0    0 0 69,842,000  
          proceeds from issuance of common stock under the employee stock plans
        		                        
          amortization of premium (accretion of discount) on marketable securities
        		                  218,000      
          accounts receivable
        		                      -5,010,000  
          proceeds from issuance of common stock, net of issuance costs
        		                  1,180,000      
          proceeds from exercise of stock options, net of repurchases
        		                  121,000      
          non-cash interest income
        		                        
          proceeds from the sale of convertible preferred stock, net of issuance costs
        		                       0 
          proceeds from issuance of common stock under the employee stock purchase plan
        		                   485,000 0    
          supplemental disclosures of non-cash financing information
        		                        
          convertible preferred stock converted to common stock
        		                        
          forgiveness of promissory notes from related party for purchase of common stock
        		                       15,000 
          offering costs included in accounts payable
        		                        
          noncash interest income
        		                        
          prepaid expenses and other long-term assets
        		                    405,000 558,000 -562,000 2,545,000 
          accounts payable and accrued liabilities
        		                    3,396,000 -610,000 2,421,000 -1,451,000 
          proceeds from issuance of common stock, net of repurchases
        		                    165,000 453,000 30,000 20,000 
          deferred offering costs included in accounts payable and accrued expenses
        		                        
          property and equipment purchases included in accounts payable
        		                        
          accretion of discount on marketable securities
        		                      -4,000  
          gain on foreign exchange
        		                        
          other noncash income
        		                        
          proceeds from initial public offering
        		                        
          property and equipment included in accounts payable