7Baggers

Quidel Corporation
(NASDAQ:QDEL) 

QDEL stock logo

Quidel Corporation develops, manufactures, and markets diagnostic testing solutions for applications in infectious diseases, cardiology, thyroid, women's and general health, eye health, gastrointestinal diseases, and toxicology worldwide. It offers Sofia and Sofia 2 fluorescent immunoassay systems; ...

Founded: 1979
Full Time Employees: 1,250
Founder: David H. Katz 
CEO: Brian J. Blaser  
Sector: Healthcare
Industry: Diagnostics & Research

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    Unit: USD2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 2009-12-31 2009-09-30 2009-06-30 2007-06-30 2007-03-31 2006-12-31 2006-09-30 2006-06-30 2006-03-31 2005-12-31 2005-09-30 2005-06-30 2005-03-31 
                                                                  
      total revenues
    1,002,259,000 636,867,000 509,736,000 176,610,000 375,338,000 809,203,000 476,058,000 201,754,000 174,653,000 152,178,000 126,492,000 108,252,000 147,968,000 132,588,000 117,399,000 103,155,000 169,143,000 114,890,000 50,894,000 38,267,000 73,692,000 52,808,000 49,341,000 39,133,000 50,321,000 52,412,000 46,812,000 34,873,000 61,302,000 63,597,000 40,857,000 31,488,000 46,673,000 50,170,000 33,539,000 29,706,000 61,995,000 53,925,000 32,998,000 30,858,000 37,960,000 38,391,000 33,108,000 27,509,000 59,595,000 31,709,000 28,225,000 25,026,000 28,379,000 66,597,000 56,152,000 24,643,000 18,580,000 33,934,000 38,774,000 23,720,000 16,471,000 27,050,000 34,778,000 20,032,000 14,823,000 22,666,000 
      yoy
    167.03% -21.30% 7.07% -12.46% 114.90% 431.75% 276.35% 86.37% 18.03% 14.78% 7.75% 4.94% -12.52% 15.40% 130.67% 169.57% 129.53% 117.56% 3.15% -2.21% 46.44% 0.76% 5.40% 12.22% -17.91% -17.59% 14.58% 10.75% 31.34% 26.76% 21.82% 6.00% -24.71% -6.96% 1.64% -3.73% 63.32% 40.46% -0.33% 12.17% -36.30% 21.07% 17.30% 9.92% 110.00% -52.39% -49.73% 1.55% 52.74% 96.25% 44.82% 3.89% 12.80% 25.45% 11.49% 18.41% 11.12% 19.34%     
      qoq
    57.37% 24.94% 188.62% -52.95% -53.62% 69.98% 135.96% 15.52% 14.77% 20.31% 16.85% -26.84% 11.60% 12.94% 13.81% -39.01% 47.22% 125.74% 33.00% -48.07% 39.55% 7.03% 26.09% -22.23% -3.99% 11.96% 34.24% -43.11% -3.61% 55.66% 29.75% -32.53% -6.97% 49.59% 12.90% -52.08% 14.97% 63.42% 6.93% -18.71% -1.12% 15.96% 20.35% -53.84% 87.94% 12.34% 12.78% -11.82% -57.39% 18.60% 127.86% 32.63% -45.25% -12.48% 63.47% 44.01% -39.11% -22.22% 73.61% 35.14% -34.60%  
      cost of sales
    262,301,000 147,525,000 136,328,000 70,424,000 73,379,000 107,709,000 92,439,000 53,003,000 59,662,000 57,338,000 50,633,000 49,073,000 57,041,000 50,456,000 47,757,000 45,487,000 62,872,000 60,885,000 19,391,000 17,755,000 23,570,000 19,119,000 17,728,000 17,318,000 19,249,000 18,122,000 16,961,000 15,493,000 21,112,000 21,263,000 16,768,000 15,902,000 20,247,000 18,679,000 15,297,000 13,671,000 19,547,000 17,597,000 14,872,000 14,008,000 14,808,000 15,286,000 14,996,000 12,540,000 20,043,000 13,811,000 12,807,000 12,237,000 12,634,000 19,049,000 17,670,000 10,075,000 9,316,000 12,952,000 15,291,000 10,344,000 8,669,000 10,514,000 12,831,000 9,280,000 6,623,000 8,367,000 
      gross profit
    739,958,000 489,342,000 373,408,000 106,186,000 301,959,000 701,494,000 383,619,000 148,751,000 114,991,000 94,840,000 75,859,000 59,179,000 90,927,000 82,132,000 69,642,000 57,668,000 106,271,000                                              
      yoy
    145.05% -30.24% -2.66% -28.61% 162.59% 639.66% 405.70% 151.36% 26.47% 15.47% 8.93% 2.62% -14.44%                                                  
      qoq
    51.21% 31.05% 251.65% -64.83% -56.95% 82.86% 157.89% 29.36% 21.25% 25.02% 28.19% -34.92% 10.71% 17.93% 20.76% -45.73%                                               
      gross margin %
    73.83% 76.84% 73.26% 60.12% 80.45% 86.69% 80.58% 73.73% 65.84% 62.32% 59.97% 54.67% 61.45% 61.95% 59.32% 55.90% 62.83% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 
      research and development
    26,368,000 26,107,000 23,676,000 22,614,000 23,304,000 25,495,000 21,448,000 20,970,000 16,379,000 14,924,000 11,976,000 11,723,000 13,930,000 12,641,000 13,103,000 13,284,000 12,621,000 10,674,000 7,468,000 7,627,000 7,875,000 7,508,000 8,801,000 9,656,000 12,707,000 9,939,000 8,419,000 9,105,000 8,051,000 9,199,000 11,506,000 8,127,000 9,081,000 11,290,000 7,462,000 7,945,000 7,524,000 7,283,000 5,085,000 6,844,000 8,504,000 5,927,000 6,134,000 6,450,000 7,814,000 5,799,000 6,148,000 6,349,000 6,275,000 3,523,000 3,157,000 2,950,000 3,282,000 3,364,000 3,144,000 3,126,000 3,498,000 3,279,000 3,525,000 2,968,000 2,986,000 3,350,000 
      sales and marketing
    65,388,000 56,214,000 46,778,000 38,100,000 34,233,000 38,239,000 37,413,000 27,567,000 30,738,000 28,000,000 26,599,000 26,926,000 29,589,000 26,380,000 26,504,000 27,545,000 28,558,000 28,435,000 12,898,000 12,360,000 13,555,000 11,445,000 11,853,000 12,206,000 12,317,000 12,063,000 12,112,000 11,592,000 11,389,000 11,153,000 11,060,000 9,393,000 9,927,000 9,667,000 8,658,000 7,120,000 8,442,000 8,330,000 7,776,000 7,677,000 6,536,000 6,755,000 6,487,000 6,254,000 6,255,000 5,904,000 5,797,000 6,272,000 5,999,000 6,809,000 6,400,000 5,403,000 4,729,000 4,655,000 4,654,000 4,080,000 4,174,000 4,058,000 4,345,000 3,610,000 3,877,000 4,289,000 
      general and administrative
    24,508,000 22,489,000 21,113,000 21,138,000 19,507,000 20,165,000 16,410,000 15,679,000 14,332,000 14,302,000 12,146,000 12,876,000 13,431,000 12,299,000 10,620,000 11,500,000 10,532,000 8,709,000 6,580,000 6,783,000 7,172,000 6,530,000 6,561,000 6,682,000 7,289,000 7,408,000 5,889,000 6,290,000 9,860,000 6,862,000 5,879,000 5,843,000 7,397,000 6,921,000 5,795,000 6,071,000 7,529,000 4,828,000 4,759,000 5,129,000 5,924,000 6,502,000 4,944,000 5,593,000 5,759,000 4,679,000 4,759,000 4,792,000 4,241,000 4,658,000 4,325,000 3,680,000 3,117,000 3,696,000 3,223,000 3,322,000 3,273,000 2,952,000 3,485,000 2,531,000 3,057,000 3,989,000 
      acquisition and integration costs
    3,037,000 7,803,000  1,028,000 726,000 519,000 389,000 872,000 1,914,000 2,551,000 4,456,000 1,836,000 2,824,000 3,274,000 2,521,000 4,935,000 3,467,000 9,484,000 4,591,000                                            
      total operating expenses
    119,301,000 112,613,000 91,567,000 82,880,000 77,770,000 84,418,000 75,660,000 65,088,000 63,363,000 59,777,000 55,177,000 53,361,000 59,774,000 54,594,000 52,748,000 57,264,000 55,178,000                                              
      operating income
    620,657,000 376,729,000 281,841,000 23,306,000 224,189,000 617,076,000 307,959,000 83,663,000 51,628,000 35,063,000 20,682,000 5,818,000 31,153,000 27,538,000 16,894,000 404,000 51,093,000 3,887,000 -2,537,000 -11,027,000 19,229,000 5,915,000 2,125,000 -9,019,000 -3,460,000 2,662,000 1,212,000 -9,825,000 8,689,000 12,915,000 -10,121,000 -9,985,000 -2,187,000 67,000 -5,968,000 -7,123,000 17,189,000 14,117,000 -1,222,000 -4,519,000 470,000 2,139,000 -1,244,000 -5,103,000 17,948,000 -595,000 -3,349,000 -7,530,000 -3,815,000 31,777,000 24,255,000 1,103,000  7,743,000         
      yoy
    176.85% -38.95% -8.48% -72.14% 334.24% 1659.91% 1389.02% 1338.00% 65.72% 27.33% 22.42% 1340.10% -39.03% 608.46% -765.90% -103.66% 165.71% -34.29% -219.39% 22.26% -655.75% 122.20% 75.33% -8.20% -139.82% -79.39% -111.98% -1.60% -497.30% 19176.12% 69.59% 40.18% -112.72% -99.53% 388.38% 57.62% 3557.23% 559.98% -1.77% -11.44% -97.38% -459.50% -62.85% -32.23% -570.46% -101.87% -113.81% -782.68%  310.40%             
      qoq
    64.75% 33.67% 1109.31% -89.60% -63.67% 100.38% 268.09% 62.05% 47.24% 69.53% 255.48% -81.32% 13.13% 63.00% 4081.68% -99.21% 1214.46% -253.21% -76.99% -157.35% 225.09% 178.35% -123.56% 160.66% -229.98% 119.64% -112.34% -213.07% -32.72% -227.61% 1.36% 356.56% -3364.18% -101.12% -16.22% -141.44% 21.76% -1255.24% -72.96% -1061.49% -78.03% -271.95% -75.62% -128.43% -3116.47% -82.23% -55.52% 97.38% -112.01% 31.01% 2099.00%            
      operating margin %
    61.93% 59.15% 55.29% 13.20% 59.73% 76.26% 64.69% 41.47% 29.56% 23.04% 16.35% 5.37% 21.05% 20.77% 14.39% 0.39% 30.21% 3.38% -4.98% -28.82% 26.09% 11.20% 4.31% -23.05% -6.88% 5.08% 2.59% -28.17% 14.17% 20.31% -24.77% -31.71% -4.69% 0.13% -17.79% -23.98% 27.73% 26.18% -3.70% -14.64% 1.24% 5.57% -3.76% -18.55% 30.12% -1.88% -11.87% -30.09% -13.44% 47.72% 43.20% 4.48% 0% 22.82% 0% 0% 0% 0% 0% 0% 0% 0% 
      interest and other expense
    29,000 -1,354,000 -347,000 -1,623,000 -2,382,000 -1,552,000 -1,797,000 -3,467,000 2,807,000                                                      
      income before income taxes
    620,628,000 375,375,000 281,494,000 21,683,000 221,807,000 615,524,000 295,778,000 80,196,000 48,821,000 32,512,000 17,530,000 565,000 26,571,000 22,730,000 10,811,000 -8,833,000 38,676,000 -680,500 -5,321,000 -13,805,000 16,404,000                                          
      provision for income taxes
    140,692,000 84,058,000 65,742,000 2,610,000 43,723,000 145,394,000 63,510,000 12,544,000 8,584,000 1,886,000 1,349,000 -705,000 1,727,000 -9,749,000 -11,000 -5,757,000 4,718,000 -226,000 204,000 -1,963,000 2,114,000    -2,703,000    1,803,000    -864,000    4,624,000 5,119,000 -851,000 -1,680,000 30,000 413,000 -574,000 -1,885,000 5,897,000 -840,000 1,882,000 -5,663,000  11,435,000 9,215,000 406,000  3,145,000     336,000 467,000  3,000,000 
      net income
    479,936,000 291,317,000 215,752,000 19,073,000 178,084,000 470,130,000 232,268,000 67,652,000 40,237,000 30,626,000 16,181,000 1,270,000 24,844,000 32,479,000 10,822,000 -3,076,000 33,958,000 -5,088,000 -5,525,000 -11,842,000 14,290,000 -1,950,000 -572,000 -7,840,000 -3,446,000 -377,000 -762,000 -8,931,000 3,991,000 7,113,000 -5,767,000 -6,908,000 -1,512,000 1,139,000 -4,361,000 -1,755,000 12,367,000 8,740,000 -676,000 -3,122,000 51,000 958,000 -1,113,000 -3,660,000 11,448,000 -426,000 -5,861,000 -2,467,000 -2,517,000 20,107,000 14,940,000 637,000 -1,712,000 4,817,000       -1,710,000  
      yoy
    169.50% -38.03% -7.11% -71.81% 342.59% 1435.07% 1335.44% 5226.93% 61.96% -5.71% 49.52% -141.29% -26.84% -738.35% -295.87% -74.02% 137.63% 160.92% 865.91% 51.05% -514.68% 417.24% -24.93% -12.22% -186.34% -105.30% -86.79% 29.28% -363.96% 524.50% 32.24% 293.62% -112.23% -86.97% 545.12% -43.79% 24149.02% 812.32% -39.26% -14.70% -99.55% -324.88% -81.01% 48.36% -554.83% -102.12% -139.23% -487.28% 47.02% 317.42%             
      qoq
    64.75% 35.02% 1031.19% -89.29% -62.12% 102.41% 243.33% 68.13% 31.38% 89.27% 1174.09% -94.89% -23.51% 200.12% -451.82% -109.06% -767.41% -7.91% -53.34% -182.87% -832.82% 240.91% -92.70% 127.51% 814.06% -50.52% -91.47% -323.78% -43.89% -223.34% -16.52% 356.88% -232.75% -126.12% 148.49% -114.19% 41.50% -1392.90% -78.35% -6221.57% -94.68% -186.07% -69.59% -131.97% -2787.32% -92.73% 137.58% -1.99% -112.52% 34.59% 2245.37% -137.21% -135.54%          
      net income margin %
    47.89% 45.74% 42.33% 10.80% 47.45% 58.10% 48.79% 33.53% 23.04% 20.13% 12.79% 1.17% 16.79% 24.50% 9.22% -2.98% 20.08% -4.43% -10.86% -30.95% 19.39% -3.69% -1.16% -20.03% -6.85% -0.72% -1.63% -25.61% 6.51% 11.18% -14.12% -21.94% -3.24% 2.27% -13.00% -5.91% 19.95% 16.21% -2.05% -10.12% 0.13% 2.50% -3.36% -13.30% 19.21% -1.34% -20.77% -9.86% -8.87% 30.19% 26.61% 2.58% -9.21% 14.20% 0% 0% 0% 0% 0% 0% -11.54% 0% 
      basic earnings per share
    11.46 6.83 5.17 0.46 4.19 11.16 5.52 1.61 0.96 0.74 0.39 0.03 0.63 0.84 0.28 -0.08 0.96   -0.35 0.43    -0.11    0.12 0.2 -0.17 -0.2 -0.04 0.04 -0.13 -0.05 0.37   -0.09  0.03 -0.03 -0.11      0.68 0.5 0.02  0.15         
      diluted earnings per share
    11.31 6.71 5.08 0.45 4.09 10.78 5.33 1.55 0.93 0.71 0.38 0.03 0.6 0.78 0.27 -0.08 0.86   -0.35 0.42    -0.11    0.11 0.2 -0.17 -0.2 -0.04 0.03 -0.13 -0.05 0.36   -0.09  0.03 -0.03 -0.11      0.66 0.5 0.02  0.14         
      shares used in basic per share calculation
    41,875 421 41,728 41,691 42,510 31 42,105 42,117 42,056 340 41,642 40,209 39,704 505 39,290 37,925 35,236   33,500 33,202    32,727    34,641 8,585 34,480 34,347 34,199 8,443.5 33,975 33,802 33,501 8,259 33,004 32,946 32,997 8,208.25 33,019 32,900 32,451 7,090.5 28,183 28,406  7,537.75 29,713 29,677 31,682 32,655 8,265 32,551 33,347 33,269 195 32,808  31,906 
      shares used in diluted per share calculation
    42,449 403 42,463 42,374 43,533 43,596 43,746 43,403 60 43,206 41,429 42,907 87 42,889 37,925 41,948   33,500 33,998    32,727    35,745 8,585 34,480 34,347 34,199 8,708.5 33,975 33,802 34,575 8,259 33,004 32,946 33,504 8,297.25 33,019 32,900 32,838 7,090.5 28,183 28,406  7,636.75 30,149 30,063 31,682 33,629 8,600 33,744 33,347 34,708 195 33,787  31,906 
      other expense
                                    -16,000     -3,000 -27,000                        
      loss on extinguishment of debt
          -10,384,000     -748,000  -2,065,500 -1,297,000 -2,398,000 -4,567,000                                              
      total other expense
     -1,354,000 -347,000   -1,552,000 -12,181,000 -3,467,000  -2,551,000 -3,152,000 -5,253,000 -4,582,000 -4,808,000 -6,083,000 -9,237,000 -12,417,000                -189,000 -156,000 -188,000 -189,000 -198,000 -258,000 -305,000 -283,000 -389,000 -768,000 -443,000 -442,000 -603,000 -365,000 -630,000            19,750 45,000 23,000  
      interest expense
             -3,059,750 -3,152,000 -4,505,000 -4,582,000 -4,808,000 -4,786,000 -6,839,000 -7,850,000 -9,201,000 -2,784,000 -2,778,000 -2,825,000 -3,141,000 -3,006,000 -2,924,000 -2,689,000 -2,989,000 -3,090,000 -3,061,000 -2,895,000 -820,000 -224,000 -372,000 -179,000 -187,000 -191,000 -195,000 -204,000 -261,000 -286,000 -292,000 -407,000 -444,000 -485,000 -499,000 -655,000 -690,000 -645,000 -611,000 -399,000 -308,000 -148,000 -153,000   143,250 188,000 191,000  -1,419,000 201,000 204,000  
      other expense, net:
                                                                  
      costs and expenses
                                                                  
      amortization of intangible assets from acquired businesses and technology
                     1,796,000 2,503,000 2,390,000 2,291,000 2,291,000 2,273,000 2,290,000 2,219,000 2,218,000 2,219,000 2,218,000 2,201,000 2,205,000 2,207,000 2,208,000 2,208,000 2,214,000 2,171,000 2,022,000 1,764,000 1,770,000 1,728,000 1,719,000 1,718,000 1,782,000 1,791,000                    
      total costs and expenses
                     39,297,000 53,431,000 49,294,000 54,463,000 46,893,000 47,216,000 48,152,000 53,781,000 49,750,000 45,600,000 44,698,000 52,613,000 50,682,000 50,978,000 41,473,000 48,860,000 50,103,000 39,507,000 36,829,000 44,806,000 39,808,000 34,220,000 35,377,000 37,490,000 36,252,000 34,352,000 32,612,000 41,647,000 32,304,000 31,574,000 32,556,000 32,194,000 34,820,000 31,897,000 23,540,000 21,742,000 26,191,000 27,913,000 21,721,000 20,679,000 21,868,000 24,717,000 18,704,000 16,858,000 37,310,000 
      basic and diluted loss per share
                     -0.15 -0.16   -0.06 -0.02 -0.24  -0.043 -0.02 -0.26                     -0.09              
      shares used in basic and diluted per share calculation
                     196 33,913   63 32,673 32,541                         28,505            32,263  
      one-time acquisition costs
                       2,379,000                                           
      loss before taxes
                         -4,743,250 -881,000 -11,943,000                                       
      benefit for income taxes
                         4,724,000 -309,000 -4,103,000  50,000 -1,116,000 -3,955,000  -2,222,750 -4,578,000 -3,449,000  -682,000 -1,795,000 -5,557,000             -1,528,000              
      income before taxes
                            -6,149,000     -5,769,500 -10,345,000 -10,357,000 -2,376,000 880,750 -6,156,000 -7,312,000 16,991,000 -1,562,000 -1,527,000 -4,802,000 81,000 2,528,250 -1,687,000 -5,545,000    -8,130,000  5,151,750 24,155,000 1,043,000  7,962,000         
      impairment loss
                                  3,558,000                                
      loss before benefit for income taxes
                             -2,242,500 -1,878,000 -12,886,000                     -4,045,000              
      weighted shares used in basic and diluted per share calculation
                              33,683 34,597                                   
      income before provision for income taxes
                                5,794,000                17,345,000                  
      facility restructuring charge
                                     123,250 124,000                            
      other income
                                                      -5,000  36,000     23,000     
      interest income
                                    6,000  3,000 6,000 6,000 6,000 8,000 9,000 18,000 52,000 42,000 57,000 52,000 19,000 15,000 11,000 169,000 73,000 53,000 93,000 490,000 442,000    317,000    190,000 
      basic and diluted earnings per share
                                         0.26 -0.02      0.35 -0.095 -0.21 -0.09               
      amortization of inventory fair value adjustment from acquisition
                                                   399,000 719,000              
      total cost of sales
                                             15,286,000 14,996,000 12,540,000 20,043,000 13,811,000 12,807,000 12,636,000 13,353,000              
      business acquisition and integration costs, and restructuring charges
                                                 95,000 115,000 716,000 1,350,000              
      amortization of intangible assets from acquired businesses
                                               1,631,000 1,632,000 1,623,000 1,624,000 1,467,000 652,000              
      amortization of intangible assets from licensed technology
                                               144,000 144,000 393,000 324,000 324,000 324,000              
      business acquisition and integration costs
                                                                  
      income before provision for taxes
                                                 -1,266,000 -3,979,000                
      total other income
                                                   -600,000 -230,000 -235,000 -100,000 -60,000 333,000 219,000    146,000     
      amortization of intangibles
                                                     260,000 345,000 347,000 1,298,000 1,524,000 1,601,000 849,000 1,065,000 1,065,000 531,000 315,000 315,000 315,000 
      restructuring charges
                                                       1,085,000           
      revenues
                                                                  
      basic earnings (loss) per share
                                                        -0.05          
      diluted earnings (loss) per share
                                                                  
      net sales
                                                          38,422,000 23,436,000 16,201,000 26,673,000 34,113,000 19,693,000 13,401,000 21,524,000 
      research contracts, license fees and royalty income
                                                          352,000 284,000 270,000 377,000 665,000 339,000 1,422,000 1,142,000 
      patent litigation settlement
                                                                 17,000,000 
      operating earnings
                                                          10,861,000 1,999,000  5,182,000  1,328,000   
      other
                                                          12,000 14,000 57,000     5,000 
      earnings from continuing operations before provision for income taxes
                                                          11,608,000 2,143,000  5,328,000  1,283,000   
      earnings from continuing operations
                                                          17,499,000 2,143,000  5,328,000  816,000   
      loss from discontinued operations, net of taxes
                                                                  
      net earnings
                                                          18,296,000 2,143,000 -4,049,000 5,328,000 9,602,000 700,000   
      basic earnings (loss) per share:
                                                                  
      continuing operations
                                                          0.53 0.07 -0.12 0.16 0.3 0.02 -0.04 -0.55 
      discontinued operations
                                                                  
      diluted earnings (loss) per share:
                                                                  
      basic and diluted earnings per share:
                                                                  
      basic earnings per share:
                                                                  
      diluted earnings per share:
                                                                  
      loss from continuing operations before provision for income taxes
                                                                  
      loss from continuing operations
                                                                  
      basic and diluted loss per share:
                                                                  
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 2009-12-31 2009-09-30 2009-06-30 2007-06-30 2007-03-31 2006-12-31 2006-09-30 2006-06-30 2006-03-31 2005-12-31 2005-09-30 2005-06-30 2005-03-31 
                                                                    
        assets
                                                                    
        current assets:
                                                                    
        cash and cash equivalents
      1,275,536,000 802,751,000 578,447,000 593,224,000 981,052,000 489,941,000 77,547,000 72,589,000 108,770,000 52,775,000 28,914,000 28,554,000 56,938,000 43,695,000 38,694,000 38,675,000 101,812,000 36,086,000 172,994,000 175,048,000 197,494,000 169,508,000 153,363,000 155,567,000 153,447,000 191,471,000 182,560,000 204,735,000 229,429,000 200,895,000 17,365,000 18,075,000 25,160,000 8,388,000 10,248,000 21,949,000 44,375,000 14,856,000 17,842,000 19,879,000 21,555,000 61,332,000 51,045,000 65,296,000 58,938,000 6,788,000 7,229,000 14,831,000 20,263,000 89,003,000 60,348,000 49,433,000 36,893,000 38,980,000 36,625,000 30,594,000 39,061,000 39,803,000 34,930,000 24,328,000 27,078,000 43,893,000 
        marketable securities
      44,270,000 25,758,000                                                3,999,000 4,984,000            
        accounts receivable
      569,817,000 377,969,000 335,560,000 46,216,000 70,170,000 497,688,000 353,154,000 111,027,000 102,146,000 94,496,000 77,646,000 44,643,000 69,234,000 58,677,000 66,845,000 44,703,000 92,254,000 67,046,000 41,575,000 19,836,000 20,943,000 24,990,000 26,191,000 16,232,000 26,446,000 18,398,000 31,020,000 15,694,000 18,676,000 34,466,000 24,458,000 17,233,000 16,676,000 29,928,000 19,640,000 13,595,000 14,108,000 32,570,000 17,132,000 12,781,000 14,447,000 14,646,000 17,305,000 10,870,000 16,210,000 13,477,000 12,862,000 10,235,000 13,003,000 9,717,000 25,428,000 8,808,000 8,242,000 11,479,000 18,139,000 15,303,000 6,167,000 13,497,000 15,819,000 13,242,000 6,703,000 10,160,000 
        inventories
      181,388,000 198,765,000 196,976,000 218,506,000 174,669,000 113,798,000 95,221,000 92,618,000 58,708,000 58,086,000 61,742,000 64,622,000 66,647,000 67,379,000 63,309,000 59,714,000 57,961,000 67,078,000 23,429,000 22,964,000 22,470,000 26,045,000 23,364,000 23,137,000 24,820,000 26,388,000 24,568,000 23,681,000 22,894,000 24,763,000 23,514,000 23,525,000 24,986,000 27,639,000 27,361,000 24,664,000 20,722,000 15,496,000 16,909,000 17,113,000 16,206,000 14,654,000 14,851,000 15,236,000 14,834,000 17,707,000 19,263,000 19,918,000 20,520,000 15,038,000 12,883,000 11,889,000 10,236,000 8,947,000 9,625,000 9,381,000 9,154,000 8,069,000 8,500,000 7,816,000 7,534,000 6,698,000 
        prepaid expenses and other current assets
      42,639,000 35,067,000 38,082,000 59,741,000 56,822,000 40,975,000 35,014,000 20,703,000 16,855,000 16,870,000 17,112,000 19,693,000 18,823,000 23,646,000 31,301,000 24,880,000 15,983,000 14,375,000 6,477,000 7,405,000 4,038,000 4,851,000 5,617,000 5,269,000 5,333,000 4,344,000 3,371,000 4,111,000 3,367,000 3,554,000 3,568,000 4,949,000 5,782,000 4,302,000 7,854,000 6,058,000 5,752,000 5,228,000 6,380,000 3,859,000 4,766,000 3,246,000 3,529,000 2,835,000 3,029,000 2,552,000 3,499,000 3,118,000 4,046,000 2,448,000 1,973,000 1,780,000 2,413,000 2,222,000 1,690,000    1,354,000    
        total current assets
      2,113,650,000 1,440,310,000 1,149,065,000 917,687,000 1,282,713,000 1,142,402,000 560,936,000 296,937,000 286,479,000 222,227,000 185,414,000 157,512,000 211,642,000 193,397,000 200,149,000 167,972,000 268,010,000 331,229,000 244,475,000 225,253,000 244,945,000 225,394,000 208,535,000 200,205,000 210,046,000 240,664,000 251,083,000 260,611,000 285,291,000 275,121,000 89,718,000 72,016,000 80,965,000 78,619,000 70,518,000 71,001,000 91,579,000 74,772,000 69,080,000 64,449,000 67,791,000 104,726,000 92,841,000 99,797,000 107,135,000 56,027,000 55,617,000 64,577,000 75,147,000 126,223,000 110,659,000 78,337,000 59,374,000 63,218,000 67,669,000 56,860,000 56,270,000 63,576,000 60,603,000 46,810,000 42,984,000 63,178,000 
        property, plant and equipment
      364,248,000 349,202,000 319,949,000 251,045,000 169,627,000 110,481,000 87,697,000 83,723,000 79,915,000 79,762,000 79,183,000 76,909,000 75,356,000 73,901,000 70,235,000 66,522,000 62,856,000 61,585,000 50,035,000 51,015,000 49,880,000 50,858,000 50,204,000 50,238,000 51,957,000 52,547,000 52,267,000 50,511,000 49,315,000 49,226,000 48,886,000 50,302,000 50,389,000 48,057,000 45,343,000 41,404,000 36,565,000 34,156,000        31,755,000    21,251,000   19,227,000 19,348,000 20,058,000    19,557,000    
        marketable securities, non-current
      20,726,000 37,852,000                                                             
        right-of-use assets
      125,059,000 127,622,000 132,227,000 134,870,000 137,436,000 100,544,000 102,104,000 88,906,000 90,490,000 92,119,000 82,075,000 84,368,000 85,907,000                                                  
        goodwill
      337,017,000 337,021,000 337,023,000 337,027,000 337,026,000 337,032,000 337,024,000 337,019,000 337,017,000 337,018,000 337,016,000 337,021,000 337,019,000 337,021,000 337,025,000 337,023,000 337,032,000 337,028,000 91,433,000 91,676,000 83,837,000 83,834,000 83,864,000 83,825,000 83,828,000 80,730,000 80,733,000 80,732,000 80,729,000 80,748,000 80,763,000 80,763,000 80,763,000 80,763,000 81,538,000 82,716,000 71,013,000 71,013,000 71,013,000 71,013,000 71,013,000 71,013,000 71,013,000 71,013,000 71,013,000 71,013,000 70,411,000 70,827,000 70,935,000       13,072,000 13,072,000      
        intangible assets
      91,584,000 98,655,000 105,696,000 109,537,000 116,156,000 122,431,000 128,251,000 134,456,000 141,268,000 148,112,000 154,459,000 161,137,000 168,120,000 175,029,000 181,985,000 188,968,000 195,967,000 203,827,000 27,364,000 29,777,000 25,270,000 27,639,000 28,616,000 30,319,000 32,159,000 31,833,000 34,138,000 36,500,000 38,858,000 41,890,000 46,871,000 53,838,000 57,611,000 62,262,000 66,365,000 68,289,000 56,206,000 60,341,000 64,179,000 66,863,000 70,159,000 73,830,000 76,210,000 50,094,000 51,885,000 53,675,000 54,705,000 54,666,000 56,473,000 8,413,000 8,753,000 9,113,000 15,948,000 17,242,000 18,797,000   22,850,000 23,964,000 23,041,000 17,803,000 18,165,000 
        deferred tax asset
      20,232,000 20,089,000 43,994,000 44,151,000 44,316,000 44,762,000 24,943,000 24,523,000 24,424,000 24,502,000                                              8,864,000 8,864,000 8,864,000  8,994,000 9,461,000 8,534,000 
        other non-current assets
      20,609,000 19,623,000 18,428,000 13,335,000 10,095,000 13,512,000 8,403,000 7,367,000 7,173,000 7,127,000 6,893,000 6,559,000 5,709,000 4,831,000 4,490,000 3,016,000 1,778,000 1,582,000 514,000 569,000 565,000 525,000 532,000 520,000 768,000 731,000 821,000 857,000 1,000,000 4,565,000 1,499,000 1,595,000 1,691,000 1,784,000 1,756,000 1,691,000 1,713,000 1,817,000 1,970,000 1,110,000 1,310,000 1,239,000 1,434,000 1,413,000 1,566,000 2,123,000 1,788,000 1,706,000 1,876,000 1,393,000 1,518,000 1,533,000 496,000 496,000 459,000 659,000 708,000 783,000  854,000 909,000 900,000 
        total assets
      3,093,125,000 2,430,374,000 2,106,382,000 1,807,652,000 2,097,369,000 1,871,164,000 1,249,358,000 972,931,000 966,766,000 910,867,000 867,516,000 846,181,000 905,855,000 806,371,000 793,884,000 763,501,000 865,643,000 935,251,000 413,821,000 398,537,000 404,497,000 388,250,000 376,497,000 369,696,000 378,758,000 406,505,000 419,042,000 429,211,000 455,193,000 451,550,000 267,737,000 258,514,000 271,419,000 271,485,000 265,520,000 265,101,000 257,076,000 242,099,000 236,777,000 232,511,000 238,030,000 278,894,000 273,283,000 254,258,000 263,327,000 214,593,000 213,463,000 221,090,000 233,410,000 166,345,000 149,799,000 118,817,000 113,882,000 118,023,000 127,048,000 107,513,000 108,183,000 115,833,000 113,848,000 98,498,000 90,243,000 110,256,000 
        liabilities and stockholders’ equity
                                                                    
        current liabilities:
                                                                    
        accounts payable
      157,472,000 101,492,000 82,698,000 99,562,000 82,125,000 86,316,000 49,370,000 37,470,000 33,153,000 26,701,000 30,397,000 24,837,000 26,827,000 25,171,000 25,700,000 21,737,000 27,308,000 27,279,000 15,657,000 11,215,000 10,433,000 16,047,000 11,296,000 7,451,000 11,338,000 8,675,000 11,003,000 8,912,000 8,485,000 12,421,000 6,265,000 5,890,000 6,969,000 6,950,000 7,367,000 5,286,000 6,761,000 7,864,000 4,679,000 4,734,000 6,518,000 5,001,000 4,583,000 3,630,000 4,736,000 4,715,000 4,824,000 5,884,000 4,499,000 5,212,000 6,057,000 2,614,000 4,077,000 2,823,000 3,832,000 4,175,000 3,590,000 3,998,000 5,134,000 3,855,000 3,045,000 4,539,000 
        accrued payroll and related expenses
      27,820,000 40,385,000 30,149,000 16,559,000 16,612,000 34,781,000 28,216,000 22,506,000 14,195,000 17,286,000 12,223,000 13,917,000 10,969,000 19,210,000 17,118,000 15,317,000 9,942,000 15,926,000 9,771,000 9,426,000 7,259,000 9,642,000 7,907,000 8,086,000 6,147,000 9,627,000 9,264,000 7,706,000 7,365,000 8,349,000 7,387,000 6,070,000 6,211,000 7,485,000 6,796,000 5,537,000 5,475,000 6,016,000 5,394,000 4,436,000 4,200,000 5,377,000 5,766,000 4,655,000 4,740,000 3,013,000 3,977,000 4,297,000 5,034,000 5,187,000 4,715,000 3,440,000   1,976,000 1,923,000   1,847,000    
        income taxes payable
      205,240,000 66,945,000 71,993,000 6,585,000 169,619,000  51,376,000            1,124,000 1,101,000 1,045,000 1,045,000 985,000 985,000 910,000 910,000 1,746,000 806,000 806,000 806,000 1,964,000 2,076,000 2,118,000 2,118,000 1,945,000 1,548,000 5,347,000 4,548,000 4,413,000 4,667,000 4,667,000 4,667,000 2,937,000 2,829,000 2,929,000  758,000   6,151,000             
        operating lease liabilities
      9,715,000 10,039,000 9,618,000 8,952,000 8,149,000 7,799,000 7,442,000 6,670,000 6,523,000 6,412,000 5,598,000 82,386,000 83,818,000                                                  
        contingent consideration
      5,957,000 5,986,000 5,835,000 5,845,000 5,957,000 5,987,000 5,801,000 5,811,000 5,936,000 5,969,000 5,746,000  15,129,000  14,904,000 14,904,000                                               
        deferred consideration
      41,970,000 41,945,000 41,922,000 41,898,000 42,000,000 42,000,000 42,000,000 42,000,000 42,000,000 42,000,000 42,000,000  145,501,000  140,845,000 138,559,000                                               
        other current liabilities
      44,482,000 56,728,000 54,873,000 29,866,000 42,474,000 32,290,000 16,985,000 28,413,000 21,612,000 14,862,000 10,474,000 7,694,000 13,521,000 12,992,000 13,898,000 10,713,000 14,062,000 12,666,000 9,061,000 6,255,000 8,967,000 4,999,000 4,891,000 5,036,000 7,025,000 6,999,000 9,238,000 10,070,000 13,980,000 8,043,000 8,444,000 5,557,000 8,433,000 7,640,000 4,040,000 5,192,000 7,239,000 8,649,000 4,760,000 3,039,000 3,804,000 7,126,000 7,034,000 5,234,000 5,134,000 5,507,000 5,440,000 4,884,000 6,170,000 7,227,000 7,270,000 971,000 1,345,000 2,050,000 4,564,000    5,623,000    
        total current liabilities
      492,656,000 323,520,000 297,088,000 209,267,000 366,936,000 336,961,000 207,886,000 182,978,000 136,196,000 125,891,000 127,172,000 112,112,000 159,553,000 159,735,000 158,449,000 152,313,000 197,296,000 128,348,000 38,935,000 31,327,000 29,130,000 33,612,000 25,348,000 23,287,000 28,143,000 30,830,000 36,330,000 34,224,000 36,122,000 36,385,000 31,119,000 19,607,000 23,694,000 24,009,000 21,168,000 18,219,000 22,841,000 23,161,000 15,429,000 12,953,000 15,257,000 32,926,000 33,916,000 15,549,000 19,365,000 15,777,000 17,159,000 16,956,000 18,266,000 29,524,000 23,635,000 9,935,000 12,209,000 12,222,000 14,606,000 14,110,000 11,142,000 12,482,000 16,619,000 12,509,000 7,166,000 27,002,000 
        operating lease liabilities - non-current
      135,668,000 128,556,000 133,212,000 135,660,000 138,042,000 100,706,000 102,357,000 89,887,000 91,571,000 93,227,000 80,924,000                                                    
        deferred consideration - non-current
      37,448,000 36,491,000 35,545,000 34,611,000 75,403,000 73,951,000 72,408,000 70,994,000 111,277,000 109,382,000 107,510,000 105,662,000  143,158,000    177,158,000                                             
        contingent consideration - non-current
      87,000 87,000   5,909,000 5,909,000 5,539,000 5,538,000 10,565,000 10,566,000 9,948,000 9,948,000  15,129,000    18,008,000                                             
        other non-current liabilities
      12,344,000 12,358,000 6,470,000 17,035,000 21,365,000 20,934,000 11,921,000 11,825,000 11,958,000 11,981,000 7,799,000 7,922,000 7,968,000 9,577,000 8,044,000 7,857,000 7,142,000 6,941,000 317,000 302,000 287,000 272,000 317,000 299,000 282,000 264,000 265,000 245,000 515,000 493,000 784,000 1,166,000 3,155,000 2,820,000 1,299,000 903,000 1,658,000 694,000 952,000 1,011,000 1,096,000 928,000 1,015,000 1,100,000 1,186,000 1,271,000 2,104,000 2,148,000 2,191,000 696,000 1,807,000 1,864,000           
        commitments and contingencies
                                                                    
        stockholders’ equity:
                                                                    
        preferred stock, 0.001 par value per share...
                                                                    
        common stock, 0.001 par value per share...
      42,000  42,000 42,000 43,000  42,000 42,000 42,000                                                      
        additional paid-in capital
      285,508,000 279,768,000 275,325,000 267,890,000 366,454,000 388,121,000 375,255,000 369,425,000 430,499,000 425,557,000 429,920,000 421,996,000 374,148,000 363,921,000 359,186,000 350,401,000 309,051,000 239,489,000 226,186,000 214,380,000 210,094,000 204,905,000 199,049,000 194,769,000 192,293,000 209,121,000 209,474,000 219,402,000 231,806,000 229,374,000 208,838,000 205,523,000 203,772,000 201,021,000 196,060,000 193,526,000 190,702,000 184,431,000 180,059,000 176,471,000 174,705,000 175,030,000 172,932,000 171,011,000 169,209,000 109,802,000 108,050,000 106,749,000 109,758,000 112,426,000 124,227,000 121,543,000 141,291,000 143,447,000 155,357,000 153,056,000 158,631,000 160,704,000 161,662,000 160,039,000 157,969,000 153,687,000 
        accumulated other comprehensive income
      239,000 355,000 820,000 1,019,000 162,000      143,000 49,000    6,000 20,000       -33,000      -29,000 -17,000 3,000 7,000 18,000                34,000             
        retained earnings
      2,129,133,000 1,649,197,000 1,357,880,000 1,142,128,000 1,123,055,000 944,971,000 474,841,000 242,573,000 174,921,000 134,684,000 104,058,000 87,877,000 86,607,000 61,763,000 29,284,000 18,462,000 21,538,000    10,035,000    6,107,000 9,553,000 9,930,000 10,692,000 19,623,000 15,632,000 8,519,000 14,286,000 21,194,000 22,706,000 21,567,000 25,928,000 27,683,000 15,316,000 6,576,000 7,252,000 10,374,000 10,323,000 9,365,000 10,478,000 14,138,000 2,690,000 3,115,000 8,976,000 11,443,000 13,961,000             
        total stockholders’ equity
      2,414,922,000 1,929,362,000 1,634,067,000 1,411,079,000 1,489,714,000 1,332,703,000 849,247,000 611,709,000 605,199,000 559,820,000 534,163,000 509,963,000 460,698,000 425,584,000 388,454,000 368,908,000 330,646,000 227,104,000 218,884,000 212,588,000 220,118,000 200,630,000 196,747,000 193,035,000 198,403,000 218,676,000 219,414,000 230,113,000 251,451,000 245,011,000 217,374,000 219,846,000 225,007,000 223,779,000 217,661,000 219,488,000 218,419,000 199,780,000 186,668,000 183,756,000 185,112,000 185,386,000 182,330,000 181,522,000 183,380,000 112,521,000 111,194,000 115,753,000 121,230,000 126,450,000 118,111,000 100,487,000 93,034,000 96,896,000 103,276,000 84,027,000 87,457,000 93,564,000 87,243,000 75,814,000 72,696,000 72,672,000 
        total liabilities and stockholders’ equity
      3,093,125,000 2,430,374,000 2,106,382,000 1,807,652,000 2,097,369,000 1,871,164,000 1,249,358,000 972,931,000 966,766,000 910,867,000 867,516,000 846,181,000 905,855,000 806,371,000 793,884,000 763,501,000 865,643,000 935,251,000 413,821,000 398,537,000 404,497,000 388,250,000 376,497,000 369,696,000 378,758,000 406,505,000 419,042,000 429,211,000 455,193,000 451,550,000 267,737,000 258,514,000 271,419,000 271,485,000 265,520,000 265,101,000 257,076,000 242,099,000 236,777,000 232,511,000 238,030,000 278,894,000 273,283,000 254,258,000 263,327,000 214,593,000 213,463,000 221,090,000 233,410,000 166,345,000 149,799,000 118,817,000 113,882,000 118,023,000 127,048,000 107,513,000 108,183,000 115,833,000 113,848,000 98,498,000 90,243,000 110,256,000 
        preferred stock, .001 par value per share...
                                                                    
        common stock, .001 par value per share...
       42,000    42,000    42,000 42,000 41,000 40,000 39,000 39,000 39,000 37,000 35,000 34,000 33,000 33,000 33,000 33,000 32,000 32,000 33,000 33,000 34,000 34,000 34,000 34,000 34,000 34,000 34,000 34,000 34,000 34,000 33,000 33,000 33,000 33,000 33,000 33,000 33,000 33,000 29,000 29,000 28,000 29,000 29,000 30,000 30,000 32,000 33,000 33,000        
        income tax payable
           127,788,000                                                         
        convertible senior notes
            6,696,000 12,844,000 12,777,000 12,661,000 12,546,000 12,431,000      149,868,000                                             
        accumulated other comprehensive loss
           -431,000 -891,000 -331,000 -263,000 -463,000   -97,000 -139,000 -55,000    -4,000 -18,000 -44,000 -53,000 -30,000  -29,000 -31,000 -23,000 -15,000 -12,000                                  
        convertible senior notes derivative
             27,264,000                                                       
        revolving credit facility - non-current
                                                                    
        deferred tax asset—non-current
                22,476,000 22,675,000 22,102,000 22,192,000      247,000   4,746,000 4,589,000                          9,065,000 9,040,000 11,240,000 18,837,000 17,719,000 20,065,000        
        revolving credit facility
                8,188,000 18,188,000 33,188,000 53,188,000 83,188,000                                                
        current portion of operating lease liabilities
                 5,474,000 5,385,000                                                  
        current portion of contingent consideration
                 5,759,000 3,971,000 3,983,000 3,848,000 7,125,000 5,276,000 6,293,000 4,324,000 4,317,000 2,365,000 2,826,000 630,000 1,143,000 1,125,000 1,286,000 598,000 599,000 598,000 733,000 619,000 1,616,000 1,624,000 1,493,000 2,540,000 1,795,000                           
        current portion of deferred consideration
                 42,000,000 44,000,000 44,000,000 44,000,000 44,000,000 46,000,000 46,000,000                                             
        current portion of convertible senior notes
                  54,880,000 54,379,000 53,885,000 53,421,000 87,790,000                                              
        assets held for sale
                       146,644,000                                            500,000 
        current portion of revolving credit facility
                       10,000,000                                             
        current portion of term loan
                      6,918,000                                              
        term loan
                     80,960,000 132,167,000 227,394,000                                             
        deferred tax liability - non-current
                       430,000                                             
        deferred consideration—non-current
                      179,952,000                                              
        contingent consideration—non-current
                      18,008,000  356,000 374,000 2,324,000 2,349,000 4,445,000 4,532,000 4,551,000 4,230,000 5,009,000 5,009,000 5,006,000 5,023,000 6,100,000 6,119,000 6,122,000 7,315,000 7,973,000 10,124,000                           
        deferred tax liability—non-current
                      432,000  166,000 63,000 59,000 58,000 55,000 55,000 56,000 1,970,000 7,956,000 11,668,000 15,315,000 14,890,000 3,481,000 2,759,000 6,318,000 6,318,000 10,232,000 9,465,000 3,349,000 3,349,000 4,648,000 5,361,000 7,041,000 7,040,000 3,715,000 3,750,000 6,826,000 2,313,000 458,000 560,000 6,218,000              
        current portion of long-term debt
                       10,184,000                                             
        accumulated deficit
                       -12,420,000 -7,332,000 -1,807,000                               -6,146,000 -21,086,000    -70,410,000  -68,504,000  -83,434,000 -84,134,000 -82,424,000 
        current portion of lease obligation
                        122,000 114,000 106,000 98,000 624,000 610,000 596,000 585,000 710,000 643,000 576,000 509,000 491,000 474,000 457,000 441,000 425,000 409,000 394,000 380,000 367,000 353,000 341,000 329,000 316,000 303,000 292,000 280,000 260,000 241,000 223,000 234,000             
        long-term debt
                        148,469,000 147,081,000 145,705,000 144,340,000 142,986,000 141,643,000 140,311,000 143,297,000 141,946,000 140,605,000 139,276,000 142,097,000                                 
        lease obligation, net of current portion
                        3,885,000 3,919,000 3,950,000 3,979,000 3,560,000 3,722,000 3,880,000 4,032,000 4,041,000 4,237,000 4,429,000 4,617,000 4,750,000 4,880,000 5,005,000 5,126,000 5,242,000 5,354,000 5,462,000 5,567,000 5,667,000 5,763,000 5,857,000 5,947,000 6,033,000 6,117,000 6,197,000 6,276,000 6,637,000 6,709,000 6,489,000 6,527,000             
        deferred rent
                        1,685,000 1,782,000 1,879,000 1,965,000 2,054,000 2,138,000 2,222,000 2,296,000 2,335,000 2,304,000 2,273,000 2,228,000 2,165,000 2,061,000                  788,000 828,000 868,000 1,249,000 1,326,000 1,402,000 1,438,000 1,475,000 1,511,000 1,547,000 1,583,000 1,620,000 1,656,000 
        restricted cash
                               63,000 1,810,000 4,861,000 3,465,000 3,127,000 6,047,000                                
        deferred grant revenue
                             961,000 1,912,000 3,658,000 5,517,000 6,294,000 5,118,000 6,330,000 7,913,000                                
        (accumulated deficit) retained earnings
                           -4,255,000 -2,305,000 -1,733,000                                       
        deferred tax asset—current
                                7,754,000 7,529,000 7,460,000 8,316,000 14,766,000 8,234,000 8,361,000 8,362,000 5,415,000 4,735,000 6,622,000 6,622,000 10,681,000 10,681,000 10,681,000 10,681,000 6,034,000 5,063,000 5,787,000 7,159,000 7,308,000 13,383,000 13,383,000 6,018,000 5,043,000 6,427,000 1,590,000 1,590,000 1,590,000        
        long term debt
                                           5,000,000 19,000,000 19,000,000 19,000,000 42,000,000 43,337,000 43,391,000 43,444,000 73,498,000 73,551,000 76,604,000 76,656,000              
        accrued royalties
                                          288,000 252,000 229,000 391,000 394,000 15,093,000 16,217,000 1,727,000 4,463,000 2,262,000 1,900,000 1,650,000 2,340,000 5,513,000 4,652,000 1,995,000 1,720,000 2,825,000 3,559,000 2,145,000 1,366,000 2,368,000 3,367,000 1,939,000 851,000 1,088,000 
        income taxs payable
                                          2,684,000                          
        income tax receivable
                                            136,000 136,000 136,000 167,000 77,000 497,000 8,337,000 8,344,000 5,456,000                
        property and equipment
                                            30,535,000 29,076,000 27,757,000 28,086,000 31,785,000 31,941,000 31,728,000  30,942,000 29,314,000 28,979,000  19,829,000 18,594,000    20,288,000 20,603,000 19,760,000  18,799,000 19,086,000 19,479,000 
        refundable income taxes
                                                     3,092,000 3,932,000              
        current portion of obligations under capital leases
                                                        941,000 915,000 719,000 697,000 675,000 654,000 653,000 650,000 648,000 647,000 628,000 608,000 
        capital leases, net of current portion
                                                        5,418,000 5,663,000 7,390,000 7,579,000 7,764,000 7,938,000 8,109,000 8,276,000 8,439,000 8,592,000 8,761,000 8,926,000 
        payroll and related expenses
                                                          4,348,000 3,827,000         
        deferred stock compensation
                                                                 -2,166,000 -2,513,000  
        accumulated other comprehensive earnings
                                                             1,348,000 1,345,000 1,330,000 1,326,000 1,338,000 1,339,000 1,376,000 
        prepaids and other current assets
                                                             1,582,000       
        purchased intangible assets
                                                             7,770,000 8,666,000      
        other accrued liabilities
                                                             5,213,000 5,533,000 5,466,000  4,470,000 1,255,000 2,121,000 
        common stock
                                                             33,000 34,000 34,000  37,000 35,000 33,000 
        other current assets
                                                              1,888,000 2,207,000  1,424,000 1,669,000 1,927,000 
        deferred tax assets
                                                                8,864,000    
        other assets
                                                                860,000    
        deferred revenue
                                                                    
        preferred stock, .001 par value...
                                                                    
        common stock, .001 par value...
                                                                34,000    
        accrued payroll
                                                                 1,598,000 1,387,000 1,646,000 
        accrued patent litigation
                                                                   17,000,000 
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 2009-12-31 2009-09-30 2007-06-30 2007-03-31 2006-12-31 2006-09-30 2006-06-30 2006-03-31 2005-12-31 2005-09-30 2005-06-30 2005-03-31 
                                                                     
          operating activities:
                                                                     
          net income
        479,936,000 291,317,000 215,752,000 19,073,000 178,084,000 470,130,000 232,268,000 67,652,000 40,237,000 30,626,000 16,181,000 1,270,000 24,844,000 32,479,000 10,822,000 -3,076,000 33,958,000   -11,842,000 14,290,000        3,991,000 7,113,000 -5,767,000 -6,908,000 -1,512,000 1,139,000 -4,361,000 -1,755,000 12,367,000 8,740,000 -676,000 -3,122,000 51,000 958,000 -1,113,000 -3,660,000 11,448,000 -426,000    20,107,000 14,940,000 -1,712,000 4,817,000         
          adjustments to reconcile net income to net cash from operating activities:
                                                                     
          depreciation, amortization and other
        16,782,000 14,401,000 12,792,000 14,486,000 12,705,000 12,308,000 12,415,000 11,886,000 12,480,000 15,051,000 12,282,000 12,487,000 11,971,000 11,943,000 10,704,000 11,544,000 12,075,000 12,949,000 6,236,000 5,887,000 5,690,000 5,199,000 5,187,000 6,287,000 6,123,000 5,849,000 5,717,000 5,618,000 6,202,000 7,787,000 6,885,000 6,361,000 7,332,000 6,237,000 6,334,000 5,067,000 7,056,000 6,776,000 5,623,000 5,282,000 5,580,000 5,746,000 5,298,000 3,386,000 3,379,000 3,547,000 3,324,000 3,246,000 2,209,000 1,888,000 1,612,000           
          stock-based compensation expense
        7,432,000 6,727,000 7,005,000 5,846,000 5,828,000 6,458,000 5,553,000 5,130,000 3,878,000 3,168,000 3,124,000 3,372,000 3,588,000 2,519,000 2,775,000 3,479,000 2,936,000 3,123,000 1,879,000 2,138,000 1,921,000 2,166,000 1,734,000 2,106,000 1,980,000 1,706,000 1,719,000 1,926,000 2,068,000 1,952,000 1,293,000 1,242,000 2,237,000 3,324,000 1,419,000 1,887,000 2,141,000 1,597,000 1,406,000 1,732,000 1,863,000 2,347,000 1,468,000 1,914,000 1,771,000 1,277,000 1,256,000 1,415,000 1,210,000 2,020,000 787,000 1,162,000 1,259,000 863,000 968,000 934,000 633,000     
          amortization of deferred financing costs
        101,000                                                             
          accretion of interest on deferred consideration
        982,000 970,000 957,000 1,107,000 1,451,000 1,543,000 1,414,000 1,717,000 1,895,000 1,872,000 1,848,000 2,161,000 2,343,000 2,314,000 2,285,000 2,608,000 2,793,000                                             
          net change in operating lease right-of-use assets and liabilities
        9,351,000 370,000 861,000 987,000 794,000                                                         
          change in deferred tax assets and liabilities
        -89,000 23,905,000 157,000 165,000 446,000 -19,770,000 -420,000 -99,000 78,000         264,000 348,000   4,772,000 -157,000 -4,589,000 -2,629,000 2,341,000 -3,937,000 -3,716,000 1,285,000 6,497,000 -5,682,000   -5,378,000 87,000 2,426,000 937,000 3,861,000 -713,000 -1,680,000 1,000 -1,310,000 -1,006,000 -2,352,000 5,885,000                 
          changes in assets and liabilities:
                                                                     
          accounts receivable
        -191,452,000 -42,683,000 -289,559,000 24,042,000 427,052,000 -143,878,000 -241,766,000 -8,713,000 -7,737,000 -16,715,000 -33,341,000 24,679,000 -10,682,000 7,979,000 -22,085,000 47,547,000 -25,205,000 -25,470,000 -21,738,000 1,108,000 4,048,000 1,199,000 -9,958,000 10,213,000 -7,719,000 12,619,000 -15,325,000 2,984,000 15,782,000 -10,011,000 -7,224,000 -564,000 13,252,000 -10,289,000 -6,013,000 751,000 18,462,000 -15,438,000 -4,351,000 1,666,000 199,000 2,659,000 -6,435,000 5,340,000 -2,733,000 -615,000 -2,627,000 2,768,000 3,553,000 15,711,000 -16,620,000 3,237,000 6,660,000  -9,136,000 7,330,000 2,322,000     
          inventories
        17,355,000 -1,706,000 21,463,000 -43,662,000 -61,134,000 -17,954,000 -2,448,000 -33,899,000 -602,000 3,748,000 2,691,000 2,022,000 682,000 -4,129,000 -3,555,000 -1,761,000 5,471,000 -2,389,000 -465,000 -360,000 3,576,000 -2,685,000 -274,000 1,682,000 2,136,000 -1,823,000 -886,000 286,000 786,000 -1,253,000 1,000 1,459,000 2,655,000 -275,000 -2,572,000 -3,902,000 -5,226,000 1,065,000 319,000 -907,000 -1,552,000 197,000 385,000 -402,000 2,873,000 1,556,000 655,000 602,000 -393,000 -2,155,000 -994,000  678,000    431,000     
          prepaid expenses and other current and non-current assets
        -7,291,000 1,972,000 4,699,000 -6,116,000 -13,811,000 -9,184,000 -1,289,000 -4,112,000 321,000 -628,000 2,803,000 -1,856,000 3,995,000 845,000 -2,001,000 -6,586,000 -4,939,000 -8,446,000 1,241,000 -368,000 -1,540,000 495,000 -132,000 271,000 -1,186,000 -734,000 60,000 92,000 -457,000 1,152,000 -1,021,000 2,095,000 -1,439,000 3,588,000 -3,943,000 1,995,000 -504,000    -1,731,000                     
          accounts payable
        52,592,000 13,907,000 6,663,000 -6,264,000 -3,860,000 32,665,000 10,147,000 2,775,000 6,639,000 -1,995,000 5,237,000 -2,610,000 1,802,000 -964,000 5,703,000 -4,475,000 -595,000 10,828,000 6,192,000 253,000 -4,317,000 3,339,000 2,926,000 -3,092,000 1,150,000 -1,135,000 1,780,000 -531,000 -3,196,000 5,160,000 585,000 -769,000 -596,000 191,000 1,117,000 648,000 -2,607,000 2,422,000 -310,000 -1,799,000 1,232,000 415,000 952,000 -1,262,000 21,000 -141,000 -993,000 1,043,000 -2,504,000 53,000 2,574,000           
          accrued payroll and related expenses
        -10,944,000 8,874,000 12,221,000 -70,000 -16,054,000 5,946,000 5,104,000 7,834,000 -2,860,000 4,743,000 -1,743,000 2,932,000 -6,969,000 1,698,000 1,481,000 4,483,000 -5,988,000 6,148,000 345,000 2,130,000 -1,493,000 1,492,000 -341,000 1,764,000 -3,290,000 289,000 1,403,000 239,000 -870,000 841,000 1,219,000 -254,000 -559,000 419,000 1,621,000 -668,000 -317,000 1,243,000 909,000 180,000 -1,249,000 -1,436,000 1,118,000 -92,000 1,727,000 -947,000 -320,000 -737,000 -632,000 472,000 1,275,000           
          income taxes payable
        138,384,000 1,015,000 58,307,000 -167,396,000 41,386,000 85,894,000             40,000 -1,761,000 1,799,000 60,000 -10,000 165,000 -167,000 -793,000 940,000 -209,000 -2,000 -1,155,000 -63,000                               
          other current and non-current liabilities
        -12,167,000 2,092,000 25,640,000 -12,267,000 12,469,000 13,826,000 -12,903,000 6,678,000 6,634,000 8,203,000 2,888,000 -5,846,000 721,000 1,223,000 4,110,000 -2,913,000 2,323,000 2,891,000 2,793,000 -953,000 2,173,000 557,000 -304,000 -2,244,000 7,000 -2,312,000 1,953,000 -6,683,000 5,956,000 -736,000 4,289,000 -2,996,000 745,000 3,683,000 -1,397,000 -2,936,000 509,000 3,647,000 1,662,000 -850,000 -1,656,000 -593,000 958,000 21,000 -458,000 -780,000 512,000 -1,328,000 -3,040,000 -1,251,000 7,642,000           
          net cash from operating activities:
        500,972,000  77,059,000 -178,024,000 585,457,000  70,455,000 58,997,000 61,180,000  13,330,000 40,534,000 32,897,000  6,666,000 50,648,000 35,814,000  -7,523,000 -5,568,000 29,575,000  -2,350,000                                       
          investing activities:
                                                                     
          acquisitions of property, equipment, investments and intangibles
        -22,402,000 -32,325,000                                                            
          proceeds from government assistance allocated to fixed assets
         13,618,000 9,541,000 13,722,000                                                         
          purchases of marketable securities
        -15,937,000                                                 985,000            
          proceeds from sale of marketable securities
        13,669,000                                             3,999,000             
          net cash from investing activities:
        -24,670,000  -93,245,000 -65,704,000 -64,569,000  -22,724,000 -7,504,000 -5,884,000  -6,932,000 -6,791,000 -4,993,000  -9,298,000 -8,628,000 141,695,000  -4,430,000 -19,013,000 -3,712,000  -2,403,000                                       
          financing activities:
                                                                     
          proceeds from issuance of common stock
        3,527,000 240,000 2,444,000 493,000 4,373,000 789,000 2,733,000 3,286,000 2,805,000 1,626,000 4,923,000 1,386,000 6,847,000 1,016,000 6,482,000 3,897,000 5,652,000 10,180,000 9,981,000 2,200,000 3,065,000 3,754,000 2,723,000 544,000 1,554,000  1,332,000 224,000 596,000  2,127,000 537,000 1,839,000  1,346,000                498,000           
          payments on finance lease obligation
        -91,000 -67,000 -65,000 -66,000 -62,000 -158,000 -125,000 -116,000 -112,000 -109,000 -105,000 -119,000 -38,000                                                 
          payments of tax withholdings related to vesting of stock-based awards
        -6,815,000 -1,136,000 -614,000 -1,467,000 -33,929,000                                                         
          principal payments of acquisition contingent consideration
        -29,000  -10,000                                                           
          net cash from financing activities:
        -3,408,000  1,756,000 -144,321,000 -29,648,000  -43,201,000 -87,724,000 705,000  -5,957,000 -62,147,000 -14,679,000  2,476,000 -105,154,000 -111,796,000  9,890,000 2,126,000 2,121,000  2,546,000                                       
          effect of exchange rates on cash
        -109,000  -347,000 221,000 -129,000  428,000 50,000 -6,000  -81,000 20,000 18,000  175,000 -3,000 13,000  9,000 9,000 2,000  3,000 2,000 -12,000  -12,000 -9,000  -29,000                               
          net increase in cash and cash equivalents
        472,785,000 224,304,000 -14,777,000 -387,828,000 491,111,000 412,394,000 4,958,000 -36,181,000 55,995,000 23,861,000 360,000 -28,384,000 13,243,000 5,001,000 19,000 -63,137,000 65,726,000  -2,054,000 -22,446,000 27,986,000   2,120,000 -38,024,000 8,911,000 -22,175,000 -24,694,000 28,534,000 183,530,000 -710,000 -7,085,000 16,772,000   -22,426,000 29,519,000 -2,986,000 -2,037,000 -1,676,000 -39,777,000 10,287,000 -14,251,000 6,358,000 52,150,000 -441,000    28,655,000 10,915,000 -2,087,000 2,355,000   -742,000 4,873,000    7,571,000 
          cash and cash equivalents, beginning of period
        802,751,000 489,941,000 52,775,000 43,695,000 36,086,000 169,508,000 191,471,000 200,895,000 8,388,000 14,856,000  61,332,000  6,788,000  89,003,000  36,625,000  34,930,000  36,322,000 
          cash and cash equivalents, end of period
        1,275,536,000  -14,777,000 -387,828,000 981,052,000  4,958,000 -36,181,000 108,770,000  360,000 -28,384,000 56,938,000  19,000 -63,137,000 101,812,000  -2,054,000 -22,446,000 197,494,000  -2,204,000 2,120,000 153,447,000  -22,175,000 -24,694,000 229,429,000  -710,000 -7,085,000 25,160,000  -11,701,000 -22,426,000 44,375,000  -2,037,000 -1,676,000 21,555,000  -14,251,000 6,358,000 58,938,000  -7,602,000 -5,432,000 20,263,000  10,915,000 -2,087,000 38,980,000  -8,467,000 -742,000 39,803,000  -2,750,000 -16,815,000 43,893,000 
          supplemental disclosures of non-cash investing and financing transactions:
                                                                     
          purchase of property, equipment and intangibles by incurring current liabilities
        13,714,000  -23,483,000 23,880,000 7,284,000  1,361,000                                                       
          capital expenditures to be reimbursed under a government contract
           997,000 12,622,000                                                         
          reduction of other current liabilities upon issuance of restricted share units
        2,850,000  2,001,000                       408,000  663,000  9,000 447,000                         
          operating activities
                                                                     
          impairment loss
                 337,000                                                   
          amortization of debt discount and deferred issuance costs
         100,000 101,000 101,000 101,000 156,000 182,000 216,000 217,000 215,000 216,000 549,000 602,000 597,000 641,000 1,043,000 1,671,000 1,893,000 1,388,000 1,376,000 1,365,000 1,625,000 1,412,000 1,425,000 1,429,000 1,432,000 1,422,000 1,411,000 1,399,000                                 
          change in fair value of acquisition contingencies
         116,000   557,000   841,000   369,000       104,000        -952,000 42,000                             
          change in fair value of derivative liabilities - convertible notes
                                                                     
          payment of accreted interest on contingent and deferred consideration
                                                                   
          loss on extinguishment of debt
                  1,297,000 2,398,000 4,567,000                                             
          net cash from operating activities
                                -7,597,000 16,057,000 -3,010,000 -8,504,000 31,766,000 18,208,000 186,000 -4,865,000 22,157,000 1,464,000 -5,098,000 -5,129,000 34,445,000 13,748,000 1,619,000 1,480,000 2,786,000 13,111,000 142,000 8,093,000 25,636,000 3,097,000 667,000 -36,000 -14,021,000 45,089,000 15,864,000      5,776,000    7,810,000 
          capital expenditures
                                -4,965,000 -4,655,000 -4,481,000 -2,867,000 -2,657,000 -1,873,000 -2,652,000 -3,967,000 -3,879,000 -5,194,000 -8,928,000 -2,820,000 -5,318,000 -2,918,000 -2,927,000 -1,058,000 -201,000 -1,348,000 -1,518,000 -1,438,000 -2,172,000 -2,980,000 -978,000 -3,670,000 -1,591,000         
          free cash flows
                                -7,597,000 11,092,000 -7,665,000 -12,985,000 28,899,000 15,551,000 -1,687,000 -7,517,000 18,190,000 -2,415,000 -10,292,000 -14,057,000 31,625,000 8,430,000 -1,299,000 -1,447,000 1,728,000 12,910,000 -1,206,000 6,575,000 24,198,000 925,000 -2,313,000 -36,000 -14,999,000 41,419,000 14,273,000      5,776,000    7,810,000 
          investing activities
                                                                     
          net cash from investing activities
                                -7,095,000 -5,029,000 -4,655,000 -4,481,000 -2,867,000 -2,657,000 -1,873,000 -2,652,000 -4,059,000 -4,175,000 -7,720,000 -18,298,000 -3,742,000 -5,453,000 -4,112,000 -3,164,000 -15,871,000 -3,166,000 -14,637,000 -1,501,000 -1,483,000 -3,136,000 -4,759,000 -1,153,000 -125,491,000 -2,954,000 -6,628,000           
          financing activities
                                                                     
          payments on revolving credit facility
                 -8,188,000 -10,000,000 -15,000,000 -20,000,000 -30,000,000 -10,000,000                                             
          repurchases of common stock
           -657,000 -2,384,000 -42,894,000 -1,954,000 -8,828,000 -29,000 -395,000 -1,476,000 -554,000 -183,000 -375,000 -3,232,000 -53,000 -51,000 -437,000 -72,000 -17,000 -20,079,000 -3,317,000 -15,484,000 -11,796,000 -337,000 -5,000 -1,951,000 -1,166,000 -133,000 -297,000 -561,000    -3,387,000                     
          payments on acquisition contingent consideration
                     -9,000 -3,277,000                                               
          payments of deferred consideration
                                                                
          payment on convertible note and derivative liability
                                                                     
          transaction costs related to debt exchange
                      -1,357,000                                             
          net cash from financing activities
                                -23,320,000 -2,121,000 -14,510,000 -11,697,000 -356,000 167,951,000 1,006,000 429,000 -1,326,000 856,000 1,117,000 1,001,000 -1,184,000 -11,281,000 456,000 8,000 -26,692,000 342,000 244,000 -234,000 27,997,000 -402,000 -3,510,000 -4,243,000 70,772,000 -13,480,000 1,679,000      164,000 1,597,000 1,922,000 1,383,000 225,000 
          effect of exchange rate changes on cash
                                                                     
          cash and cash equivalents, at end of period
                                                                     
          change in fair value of derivative liabilities - convertible senior notes
                                                                   
          principal payments of deferred consideration
          1,000                                                           
          payment on convertible senior note and derivative liability
             -30,000                                                        
          extinguishment of convertible senior notes through issuance of stock
                                                                     
          acquisitions of property, equipment and intangibles
           -75,245,000 -78,291,000 -28,815,000 -22,724,000 -7,504,000 -5,884,000     -8,814,000 -9,298,000 -8,628,000 -4,949,000 -4,743,000 -4,697,000 -4,358,000 -3,712,000 -4,049,000 -2,436,000 -3,423,000 -2,001,000                                     
          initial measurement of derivative liabilities – convertible senior notes
                                                                     
          payments of acquisition contingent consideration
            -30,000  -9,000 -6,000,000 -34,000  -13,000 -4,019,000 -12,000                                                 
          amortization of inventory step-up to fair value
                     3,650,000                                             
          proceeds from sale of summers ridge property
                     146,644,000                                             
          payments of debt issuance costs
                                 -365,000                                 
          payments of term loan
                                                                    
          extinguishment of convertible senior notes through issuance of common stock
              460,000                                                       
          acquisitions of property, equipment
                                                                     
          acquisition of other businesses, net of cash acquired
                                                                     
          acquisition of triage and bnp businesses
                                                                     
          proceeds from issuance of term loan
                                                                     
          proceeds from issuance of revolving credit facility
                                                                     
          payment of debt issuance costs
                                                                     
          acquisitions of property and equipment
                   -6,791,000 -4,993,000             -4,965,000 -4,655,000 -4,481,000 -2,867,000 -2,657,000 -1,873,000 -2,652,000 -3,967,000 -3,879,000 -5,194,000 -8,928,000 -2,820,000 -5,318,000 -2,918,000 -2,927,000 -1,058,000 -201,000 -1,348,000 -1,518,000 -1,438,000 -2,172,000 -2,980,000               
          payments on lease obligation
                     -37,000 -33,000 -31,000 -29,000 -28,000 -26,000 -23,000 -21,000 -107,000 -148,000 -144,000 -141,000 -134,000 -129,000 -125,000 -121,000 -115,000 -113,000 -108,000 -105,000 -100,000 -96,000 -93,000 -91,000 -87,000 -82,000 -82,000 -78,000 -73,000 -71,000 -69,000 -67,000 -52,000 -53,000 -52,000 -48,000             
          repurchases of convertible senior notes
                             -4,459,000                                     
          income taxes receivable
                      -5,511,000 -4,388,000 3,097,000  -257,000 -2,929,000 2,063,000  -311,000 -56,000 119,000  632,000 -770,000 372,000  1,307,000                               
          payments on deferred consideration
                                                                     
          payments on term loan
                       -60,000,000 -101,813,000                                             
          payments of debt transaction costs
                                                                     
          payments on acquisition contingencies
                        -1,017,000 1,000 -12,000 -486,000 -12,000 -195,000 -129,000 -1,003,000 -1,109,000                             
          net loss
                         -5,088,000    -1,950,000 -572,000   -377,000 -762,000                     -2,467,000 -2,517,000             
          adjustments to reconcile net loss to net cash from operating activities:
                                                                     
          gain on extinguishment of convertible senior notes
                             -421,000                                     
          restricted cash
                             63,000 1,747,000 3,051,000 -1,396,000 -338,000 2,920,000                                
          deferred grant revenue
                             -961,000 -951,000 -1,746,000 -1,859,000 -777,000 1,176,000 -1,212,000 -1,583,000                                
          payment for acquisition holdback
                                                                    
          net decrease in cash and cash equivalents
                                                       -5,432,000 -68,740,000             
          acquisition of businesses, net of cash acquired
                          267,000                                           
          acquisition of immutopics, net of cash acquired
                             33,000 -5,094,000                                     
          excess tax benefit from share-based compensation
                                         -1,409,000 -937,000             -29,000            
          proceeds from issuance of convertible senior notes
                                                                     
          net income:
                                -3,446,000                                     
          acquisition of biohelix, net of cash acquired
                                          -34,000                           
          acquisition of andiatec
                                                                     
          acquisition of intangibles
                                     -92,000  -221,000 -220,000 -922,000    -14,928,000                     
          proceeds from issuance of common stock, net of cancellations
                                            3,531,000        58,558,000 95,000 178,000 80,000 798,000             
          payments on line of credit
                                         -5,000,000 -14,000,000 -23,000,000                   
          supplemental disclosures of cash flow information:
                                                                     
          cash paid for interest
                                  286,000 3,208,000 250,000  258,000 292,000 175,000  165,000 195,000 204,000                         
          cash paid for income taxes
                                  1,282,000 517,000 121,000  24,000 392,000 51,000  956,000 944,000                         
          non-cash investing activities:
                                                                     
          purchase of capital equipment by incurring current liabilities
                                  311,000 958,000 164,000  -183,000 -308,000 760,000 -595,000 -240,000 -497,000 1,504,000 531,000 255,000 15,000 285,000 3,000 1,000 60,000 96,000 32,000 -67,000               
          non-cash financing activities:
                                                                     
          reduction of other current liabilities upon issuance of restricted stock units
                                                                    
          increase of other current liabilities for purchase of common stock
                                                                     
          loss on disposal of assets
                                              13,000                       
          purchase of business
                                                                     
          proceeds from sale of fixed assets
                                             7,000                       
          payment of note payable to state agency
                                                -1,498,000                     
          other
                                                 -138,000 -83,000 -208,000 -693,000 -635,000 234,000 -302,000             
          payment on line of credit
                                                                     
          impairment of intangible assets
                                                                     
          change in fair value of acquisition contingency
                                                                     
          accrued royalties
                                         40,000 -24,000 -45,000 36,000 23,000 -162,000 -3,000 17,000 -140,000 -1,323,000 -2,736,000 2,201,000 362,000 250,000 -690,000 -3,437,000 861,000 2,657,000           
          accrued income taxes payable
                                         -88,000 368,000 -6,331,000 2,528,000 135,000      -100,000 -8,000 -758,000 758,000 -6,151,000             
          aquisition of biohelix, net of cash acquired
                                                                     
          aquisition of andiatec
                                                                     
          aquisition of intangibles
                                                                     
          payment on acquisition contingency
                                                                     
          supplemental disclosures of cash flow information
                                                                     
          cash paid during the period for interest
                                              286,000 292,000 407,000  485,000 499,000 655,000  644,000 612,000 399,000  148,000 193,000 181,000  188,000 191,000 194,000  201,000 203,000 207,000 
          cash paid during the period for income taxes
                                                  80,000    452,000 6,500,000  6,000 182,000         
          non-cash investing activities
                                                                     
          purchase of licensed technology by incurring current liabilities
                                                 -1,734,000                    
          lease incentive for tenant improvements
                                                                     
          non-cash financing activities
                                                                     
          decrease of accrued payroll and related expenses upon issuance of common stock
                                                                     
          decrease of other non-current assets upon issuance of common stock
                                                                     
          proceeds from the sale of fixed assets
                                                115,000                     
          increase of other non-current assets upon issuance of common stock
                                                                     
          income tax payable
                                                                     
          income tax receivable
                                             136,000 31,000 -90,000 420,000 7,840,000 7,000 -2,890,000 -2,146,000               
          impairment of long-lived and intangible assets
                                                                     
          loss on disposal of property, plant and equipment
                                                            6,000         
          purchase of business, net of cash acquired of - for 2012 and 3,150 for 2010
                                                                     
          borrowing from line of credit
                                                     75,000,000             
          payments on note payable to state agency
                                                                   
          cash and cash equivalents at beginning of year
                                                                     
          cash and cash equivalents at end of year
                                                                     
          reduction of other non-current assets upon issuance of common stock
                                                                     
          prepaid expenses and other current assets
                                              -1,847,000    -694,000 194,000 -477,000 933,000 -353,000 928,000 -818,000 -475,000 -193,000           
          acquisitions of intangibles
                                              -194,000                       
          purchases of common stock
                                              -20,000   -1,000 -339,000 -286,000                
          issuance of common stock, net of cancellations
                                              1,599,000 90,000 1,271,000  453,000                   
          acquisition of other non-current assets upon issuance of common stock
                                                                     
          purchase of business, net of cash acquired of 3,150
                                                                     
          gain on sale of assets
                                                  6,000   7,000               
          payment for licensed technology
                                                                     
          other assets
                                                  -72,000 17,000 -45,000 16,000 290,000 86,000 -311,000 -19,000 -53,000   176,000 26,000 52,000 54,000     
          purchase of business, net of cash acquired of 3.1 million
                                                     20,000 -69,000               
          purchase of business, net of cash acquired of 3.0 million
                                                        -128,201,000             
          payments on borrowing from line of credit
                                                    -30,000,000                
          purchase of common stock
                                                        -4,676,000 -13,970,000           
          fees paid to establish line of credit
                                                                     
          purchase of license agreements by incurring current liabilities
                                                                     
          deferred tax asset
                                                      6,212,000 -5,658,000 -1,501,000 429,000 3,584,000           
          acquisition of property and equipment
                                                        -978,000 -3,670,000 -1,591,000           
          payments on capital lease obligation
                                                          -219,000           
          depreciation and amortization
                                                           2,437,000 2,618,000 2,963,000 1,924,000 2,210,000 2,012,000     
          deferred income taxes
                                                           -1,204,000 3,145,000         
          other accrued liabilities
                                                            216,000         
          acquisition of property, plant and equipment
                                                                     
          payments to acquire common stock
                                                                     
          proceeds from issuance of stock under stock plans
                                                           961,000 326,000  1,942,000 73,000 325,000     
          effect of exchange rate changes on cash and cash equivalents
                                                              3,000 15,000 4,000     
          net cash provided by operating activities
                                                            16,083,000         
          net cash used for investing activities
                                                                     
          net earnings
                                                             18,296,000 2,143,000       
          adjustments to reconcile net earnings to net cash from operating activities:
                                                                     
          loss on discontinued operations
                                                                     
          foreign currency translation
                                                                     
          change in deferred tax asset
                                                                     
          excess tax benefit from share based compensation
                                                                     
          deferred rent
                                                                     
          deferred revenue
                                                                     
          other current liabilities
                                                                     
          net cash from continuing operations
                                                                5,776,000    7,871,000 
          net cash used by discontinued operations
                                                                     
          acquisition of plant and equipment
                                                                     
          net increase in intangible assets
                                                                     
          payments on debt and obligations under capital leases
                                                                     
          net cash from (used for) financing activities
                                                                     
          net increase (decrease) in cash and cash equivalents
                                                                     
          loss from discontinued operations
                                                                     
          earnings from continuing operations
                                                              2,143,000 -4,049,000 5,328,000     
          adjustments to reconcile net earnings to net cash from (used by) operating activities:
                                                                     
          loss on disposal of property plant and equipment
                                                                     
          net cash from (used by) continuing operations
                                                              -1,077,000    1,648,000   
          net cash from discontinued operations
                                                                     
          net cash from (used by) operating activities
                                                              -1,077,000       
          acquisition of intangible assets
                                                                     
          payments on capital lease obligations
                                                                     
          payments to repurchase common stock
                                                                     
          net cash from (used by) financing activities
                                                                     
          accrued patent litigation
                                                                     
          adjustments to reconcile earnings from continuing operations to net cash from operating activities:
                                                                     
          compensation expense on stock awards
                                                                     
          increase in intangible assets
                                                                     
          payments on obligations under capital leases
                                                                     
          net proceeds from issuance of common stock and warrants
                                                                  2,424,000 1,528,000 368,000 
          net cash from (used by) discontinued operations