7Baggers

Personalis, Inc
(NASDAQ:PSNL) 

PSNL stock logo

Personalis, Inc. operates as a cancer genomics company worldwide. The company provides sequencing and data analysis services to support the development of cancer therapies. It offers NeXT Platform, which provides data for cancer therapy development, personalized therapies, therapy selection, and dia...

Founded: 2011
IPO Price: $17 (Jun 20, 2019)
Full Time Employees: 181
CEO: John S. West  
Sector: Healthcare
Industry: Diagnostics & Research
BiotechnologyGenomics
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At a glance:
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Quarterly
Annual
    Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 
                                
      revenue
    		15,472,000 17,345,000 14,495,000 17,203,000 20,605,000 16,800,000 25,709,000 22,580,000 19,525,000 19,675,000 18,247,000 16,699,000 18,860,000 16,722,000 14,858,000 18,240,000 15,227,000 20,682,000 22,261,000 21,670,000         
      yoy
    		-24.91% 3.24% -43.62% -23.81% 5.53% -14.61% 40.89% 35.22% 3.53% 17.66% 22.81% -8.45% 23.86% -19.15% -33.26% -15.83%             
      qoq
    		-10.80% 19.66% -15.74% -16.51% 22.65% -34.65% 13.86% 15.65% -0.76% 7.83% 9.27% -11.46% 12.79% 12.55% -18.54% 19.79% -26.38% -7.09% 2.73%          
      costs and expenses
    		                            
      cost of revenue
    		15,191,000 15,445,000 12,581,000 12,447,000 13,398,000 12,250,000 16,964,000 14,543,000 14,032,000 14,470,000 14,766,000 11,907,000 14,130,000 14,410,000 12,379,000 13,959,000 10,949,000 12,686,000 14,195,000 13,502,000         
      research and development
    		14,539,000 13,072,000 12,171,000 12,381,000 12,640,000 11,494,000 11,683,000 12,957,000 12,771,000 13,613,000 16,738,000 17,852,000 16,573,000 16,569,000 14,957,000 16,288,000 17,098,000 14,512,000 13,617,000 11,687,000 9,496,000 8,520,000 7,193,000 6,465,000 6,390,000 7,373,000 5,303,000 4,497,000 
      selling, general and administrative
    		17,903,000 14,094,000 13,034,000 14,179,000 12,263,000 11,168,000 11,444,000 11,973,000 11,602,000 11,524,000 11,971,000 12,134,000 14,097,000 17,828,000 14,781,000 15,874,000 15,486,000 13,709,000 12,140,000 11,428,000 10,421,000 10,920,000 7,793,000 7,705,000 7,274,000 6,388,000 6,056,000 5,466,000 
      total costs and expenses
    		47,633,000 42,611,000 37,786,000 39,007,000 38,301,000 34,912,000 40,091,000 39,473,000 38,405,000 43,647,000 49,040,000 42,045,000 48,685,000 48,807,000 42,117,000 46,121,000 43,533,000 40,907,000 39,952,000 36,617,000 33,371,000 33,546,000 29,469,000 28,993,000 28,786,000 25,350,000 22,883,000 19,886,000 
      income from operations
    		-32,161,000 -25,266,000 -23,291,000 -21,804,000 -17,696,000 -18,112,000 -14,382,000 -16,893,000 -18,880,000 -23,972,000 -30,793,000 -25,346,000 -29,825,000 -32,085,000 -27,259,000 -27,881,000 -28,306,000 -20,225,000 -17,691,000 -14,947,000 -12,490,000 -13,370,000 -9,653,000 -9,498,000 -9,625,000 -7,196,000 -5,730,000 -4,061,000 
      yoy
    		81.74% 39.50% 61.95% 29.07% -6.27% -24.45% -53.29% -33.35% -36.70% -25.29% 12.96% -9.09% 5.37% 58.64% 54.08% 86.53% 126.63% 51.27% 83.27% 57.37% 29.77% 85.80% 68.46% 133.88%     
      qoq
    		27.29% 8.48% 6.82% 23.21% -2.30% 25.94% -14.86% -10.52% -21.24% -22.15% 21.49% -15.02% -7.04% 17.70% -2.23% -1.50% 39.96% 14.32% 18.36% 19.67% -6.58% 38.51% 1.63% -1.32% 33.75% 25.58% 41.10%  
      operating margin %
    		-207.87% -145.67% -160.68% -126.75% -85.88% -107.81% -55.94% -74.81% -96.70% -121.84% -168.76% -151.78% -158.14% -191.87% -183.46% -152.86% -185.89% -97.79% -79.47% -68.98% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% 
      interest income
    		2,172,000 1,570,000 1,680,000 1,878,000 2,027,000 1,631,000 1,384,000 1,136,000 1,359,000 1,477,000 1,706,000 1,465,000 1,253,000 1,160,000 743,000 349,000 144,000 81,000 88,000 103,000 95,000 76,000 117,000 246,000 510,000 580,000 756,000 200,000 
      interest expense
    		-47,000 -65,000 -64,000 -48,000 -28,000 1,000 -7,000 -9,000 -9,000 -9,000 -15,000 -39,000 -47,000 -47,000 -45,000 -50,000 -59,000 -59,000 -60,000 -65,000     -2,000  -204,000 -745,000 
      other income
    		20,000 -42,000 26,000 -80,000 -46,000 59,000 -26,081,000 2,968,000 4,569,000 -4,075,000 32,000 1,000 -26,000 -88,000 80,000 50,000 19,000 -10,750 5,000 -36,000 -12,000 -29,000 -4,000 1,000 8,000 -25,000 -2,000 -1,261,000 
      income before income taxes
    		-30,016,000 -23,803,000 -21,649,000 -20,054,000 -15,743,000 -16,421,000 -39,086,000 -12,798,000 -12,961,000 -26,579,000 -29,070,000 -23,919,000 -28,645,000 -31,060,000 -26,481,000 -27,532,000 -28,202,000 -20,202,000 -17,658,000 -14,945,000 -12,407,000 -13,323,000 -9,540,000 -9,251,000 -9,109,000 -6,641,000 -6,884,000 -5,867,000 
      provision for income taxes
    		16,000 9,000 3,000 2,000 7,000 4,000 3,000 4,000 7,000 5,000 28,000 36,000 14,000 8,000 11,000 14,000 7,000 -3,000 12,000 8,000 -3,000 -18,000 -5,000 -4,000 -30,000 -4,000 -1,000 -2,000 
      net income
    		-30,032,000 -23,812,000 -21,652,000 -20,056,000 -15,750,000 -16,425,000 -39,089,000 -12,802,000 -12,968,000 -26,584,000 -29,098,000 -23,955,000 -28,659,000 -31,068,000 -26,492,000 -27,546,000 -28,209,000 -20,199,000 -17,670,000 -14,953,000 -12,404,000 -13,341,000 -9,545,000 -9,255,000 -9,139,000 -6,645,000 -6,885,000 -5,869,000 
      yoy
    		90.68% 44.97% -44.61% 56.66% 21.45% -38.21% 34.34% -46.56% -54.75% -14.43% 9.84% -13.04% 1.60% 53.81% 49.93% 84.22% 127.42% 51.41% 85.12% 61.57% 35.73% 100.77% 38.63% 57.69%     
      qoq
    		26.12% 9.98% 7.96% 27.34% -4.11% -57.98% 205.34% -1.28% -51.22% -8.64% 21.47% -16.41% -7.75% 17.27% -3.83% -2.35% 39.66% 14.31% 18.17% 20.55% -7.02% 39.77% 3.13% 1.27% 37.53% -3.49% 17.31%  
      net income margin %
    		-194.11% -137.28% -149.38% -116.58% -76.44% -97.77% -152.04% -56.70% -66.42% -135.12% -159.47% -143.45% -151.96% -185.79% -178.30% -151.02% -185.26% -97.66% -79.38% -69.00% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% 
      net income per share
    		-0.29 -0.26 -0.24 -0.23 -0.18 -0.18 -0.64 -0.24 -0.26 -0.54 -0.6 -0.5 -0.61 -0.67 -0.58 -0.6 -0.63 -0.46 -0.4 -0.34 -0.29 -0.35 -0.27 -0.29 -0.29 -0.04 -0.22 -0.89 
      weighted-average shares outstanding, basic and diluted
    		104,191,862 89,240,435 88,699,131 88,517,498 87,463,885 59,251,013 61,051,350 52,394,678 50,678,586 48,175,201 48,694,324 47,669,513 46,740,270 45,704,805 45,921,411 45,637,838 44,995,752 43,886,730 44,511,534 43,960,794 42,265,596 34,374,903 35,460,092 31,731,628 31,345,029 18,011,470 31,133,683 6,597,007 
      lease impairment
    		          5,565,000                  
      restructuring and other charges
    		         4,040,000  152,000 3,885,000                
      includes related party other expense of 26.0 million and 18.3 million for the three and nine months ended september 30, 2024, respectively.
    		                            
      revenues
    		                    20,881,000 20,176,000 19,816,000 19,495,000 19,161,000 18,154,000 17,153,000 15,825,000 
      costs of revenues
    		                    13,454,000 14,106,000 14,483,000 14,823,000 15,122,000 11,589,000 11,524,000 9,923,000 
      loss on debt extinguishment
    		                          -1,704,000  
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 
                                  
        assets
      		                            
        current assets
      		                            
        cash and cash equivalents
      		73,594,000 124,245,000 49,973,000 53,374,000 71,001,000 91,415,000 75,800,000 47,747,000 43,981,000 56,984,000 72,192,000 97,195,000 87,172,000 89,128,000 83,522,000 86,731,000 91,586,000 105,585,000 79,572,000 70,080,000 137,089,000 68,525,000 133,245,000 25,042,000 46,694,000 55,046,000 87,013,000 163,269,000 
        short-term investments
      		159,624,000 115,708,000 100,542,000 119,858,000 114,687,000 93,594,000 67,851,000 39,225,000 51,438,000 57,195,000 48,471,000 40,012,000 61,767,000 78,530,000 109,234,000 146,759,000 174,954,000 181,479,000 225,658,000 258,827,000 216,340,000 134,765,000 72,818,000 80,191,000 73,339,000 73,243,000 40,263,000  
        accounts receivable
      		13,022,000 16,203,000 14,376,000 9,952,000 10,973,000 8,140,000 13,474,000 12,921,000 11,345,000 17,730,000 13,666,000 10,132,000 18,103,000 16,642,000 13,592,000 12,877,000 13,519,000 18,468,000 10,534,000 9,278,000 8,053,000 6,349,000 5,903,000 5,375,000 5,508,000 3,300,000 4,445,000 7,465,000 
        inventory and other deferred costs
      		6,930,000 6,144,000 4,656,000 5,435,000 4,923,000 5,939,000 8,489,000 9,164,000 8,767,000 10,474,000 8,225,000 8,140,000 8,219,000 8,591,000 7,543,000 7,885,000 8,065,000 5,610,000 5,523,000 7,321,000 5,579,000 5,639,000 6,268,000 6,524,000 6,438,000 4,606,000 4,604,000 3,538,000 
        prepaid expenses and other current assets
      		5,028,000 5,651,000 4,855,000 4,724,000 4,838,000 3,927,000 4,663,000 4,046,000 4,908,000 4,361,000 5,661,000 5,476,000 7,511,000 6,808,000 8,017,000 5,788,000 5,904,000 7,089,000 7,728,000 8,803,000 5,607,000 5,441,000 5,359,000 2,989,000 3,437,000 3,383,000 3,973,000 1,897,000 
        total current assets
      		258,198,000 267,951,000 174,402,000 193,343,000 206,422,000 203,015,000 170,277,000 113,103,000 120,439,000 146,744,000 148,215,000 160,955,000 182,772,000 199,699,000 221,908,000 260,040,000 294,028,000 318,231,000 329,015,000 354,309,000 372,668,000 220,719,000 223,593,000 120,121,000 135,416,000 139,578,000 140,298,000 176,169,000 
        property and equipment
      		48,438,000 44,815,000 47,003,000 45,812,000 47,986,000 48,274,000 50,231,000 52,662,000 54,529,000 57,366,000 56,751,000 59,486,000 61,446,000 61,935,000 61,219,000 47,585,000 30,600,000 19,650,000 17,689,000 14,258,000 11,152,000 11,834,000 12,735,000 12,650,000 13,402,000 14,106,000 15,215,000 13,409,000 
        operating lease right-of-use assets
      		14,957,000 15,118,000 15,249,000 15,654,000 16,055,000 16,453,000 16,816,000 17,166,000 17,515,000 17,852,000 18,167,000 24,660,000 23,971,000 26,480,000 30,045,000 45,915,000 51,727,000 53,822,000 54,923,000 11,126,000 9,899,000 10,271,000 10,632,000 10,991,000 1,529,000 1,845,000 2,154,000 1,320,000 
        other long-term assets
      		3,802,000 6,280,000 6,185,000 3,871,000 2,845,000 2,526,000 2,563,000 2,571,000 2,793,000 3,137,000 3,503,000 3,937,000 3,991,000 4,586,000 4,689,000 4,439,000 4,292,000 4,825,000 5,067,000 3,647,000 1,787,000 2,018,000 1,852,000 1,760,000 1,531,000 1,762,000 2,024,000 947,000 
        total assets
      		325,395,000 334,164,000 242,839,000 258,680,000 273,308,000 270,268,000 239,887,000 185,502,000 195,276,000 225,099,000 226,636,000 249,038,000 272,180,000 292,700,000 317,861,000 357,979,000 380,647,000 396,528,000 406,694,000 383,340,000 395,506,000 244,842,000 248,812,000 145,522,000 151,878,000 157,291,000 159,691,000 191,845,000 
        liabilities and stockholders’ equity
      		                            
        current liabilities
      		                            
        accounts payable
      		12,676,000 12,989,000 11,147,000 9,926,000 7,914,000 6,397,000 12,450,000 9,936,000 9,179,000 14,920,000 8,963,000 8,847,000 10,927,000 12,854,000 10,784,000 21,395,000 12,275,000 9,221,000 7,288,000 8,919,000 6,522,000 8,301,000 6,514,000 7,491,000 10,337,000 7,337,000 7,764,000 8,781,000 
        accrued and other current liabilities
      		22,201,000 25,079,000 23,552,000 20,172,000 20,014,000 21,629,000 20,535,000 19,248,000 16,159,000 23,941,000 19,821,000 16,408,000 20,653,000 19,013,000 22,658,000 19,755,000 24,108,000 18,110,000 16,261,000 13,708,000 13,805,000 11,301,000 8,797,000 6,594,000 7,375,000 6,648,000 5,899,000 4,676,000 
        contract liabilities
      		4,168,000 1,562,000 1,457,000 1,625,000 1,964,000 3,100,000 3,428,000 4,174,000 3,526,000 3,288,000 3,694,000 3,337,000 2,563,000 1,264,000 297,000 356,000 3,461,000 3,982,000 2,967,000 11,460,000 18,237,000 21,034,000 20,593,000 28,952,000 34,408,000 35,977,000 33,726,000 41,866,000 
        total current liabilities
      		39,045,000 39,630,000 36,156,000 31,723,000 29,892,000 31,126,000 36,413,000 34,133,000 31,373,000 47,234,000 32,478,000 28,592,000 34,143,000 33,131,000 33,739,000 41,506,000 39,844,000 31,313,000 26,516,000 34,087,000 38,564,000 40,636,000 35,904,000 43,037,000 52,120,000 49,962,000 47,389,000 56,343,000 
        long-term operating lease liabilities
      		31,023,000 31,866,000 32,658,000 33,390,000 34,112,000 34,882,000 35,601,000 36,524,000 37,434,000 38,321,000 39,166,000 40,326,000 40,309,000 41,041,000 41,349,000 51,836,000 52,364,000 52,797,000 52,866,000 8,518,000 8,162,000 8,541,000 8,897,000 9,233,000     
        other long-term liabilities
      		562,000 1,483,000 2,610,000 2,738,000 1,959,000 1,303,000 1,112,000 1,060,000 3,022,000 5,161,000 3,786,000 4,034,000 4,096,000 389,000 374,000 5,000 1,724,000 2,117,000 2,016,000 1,988,000 360,000 720,000 471,000 129,000 556,000 639,000 910,000 468,000 
        total liabilities
      		70,630,000 72,979,000 71,424,000 67,851,000 65,963,000 67,311,000 73,126,000 73,230,000 74,582,000 95,658,000 75,430,000 72,952,000 78,548,000 74,561,000 75,462,000 93,347,000 93,932,000 86,227,000 81,398,000 44,593,000 47,086,000 49,897,000 45,272,000 52,399,000 52,676,000 50,601,000 48,299,000 74,827,000 
        commitments and contingencies
      		                            
        stockholders’ equity
      		                            
        preferred stock, 0.0001 par value — 10,000,000 shares authorized; none issued
      		                            
        common stock
      		10,000 10,000 9,000 9,000 9,000 9,000 7,000 5,000 5,000 5,000 5,000 5,000 5,000 5,000 5,000 5,000 5,000 4,000 4,000 4,000 4,000 4,000 4,000 3,000 3,000 3,000 3,000 3,000 
        additional paid-in capital
      		916,117,000 892,331,000 778,772,000 776,596,000 773,094,000 752,961,000 700,232,000 606,863,000 602,488,000 598,364,000 593,625,000 589,418,000 583,151,000 579,456,000 573,158,000 568,741,000 562,889,000 557,558,000 552,176,000 547,951,000 542,694,000 376,788,000 372,027,000 251,997,000 248,854,000 247,282,000   
        accumulated other comprehensive income
      		-70,000 104,000 82,000 20,000   87,000           -166,000 12,000 18,000 -5,000 22,000 37,000 106,000 73,000    
        accumulated deficit
      		-661,292,000 -631,260,000 -607,448,000 -585,796,000 -565,740,000 -549,990,000 -533,565,000 -494,476,000 -481,674,000 -468,706,000 -442,122,000 -413,024,000 -389,069,000 -360,410,000 -329,342,000 -302,850,000 -275,304,000 -247,095,000 -226,896,000 -209,226,000 -194,273,000 -181,869,000 -168,528,000 -158,983,000 -149,728,000 -140,589,000 -133,944,000 -127,059,000 
        total stockholders’ equity
      		254,765,000 261,185,000 171,415,000 190,829,000 207,345,000 202,957,000 166,761,000 112,272,000 120,694,000 129,441,000 151,206,000 176,086,000 193,632,000 218,139,000 242,399,000 264,632,000 286,715,000 310,301,000 325,296,000 338,747,000 348,420,000 194,945,000 203,540,000 93,123,000 99,202,000 106,690,000 111,392,000 117,018,000 
        total liabilities and stockholders’ equity
      		325,395,000 334,164,000 242,839,000 258,680,000 273,308,000 270,268,000 239,887,000 185,502,000 195,276,000 225,099,000 226,636,000 249,038,000 272,180,000 292,700,000 317,861,000 357,979,000 380,647,000 396,528,000 406,694,000 383,340,000 395,506,000 244,842,000 248,812,000 145,522,000 151,878,000    
        accumulated other comprehensive loss
      		    -18,000 -23,000  -120,000 -125,000 -222,000 -302,000 -313,000 -455,000 -912,000 -1,422,000 -1,264,000 -875,000         -6,000 -29,000 -15,000 
        short-term warrant liability
      		       775,000 2,509,000 5,085,000                   
        long-term warrant liability
      		       1,513,000 2,753,000 4,942,000                   
        includes related party current liabilities of 1.7 million as of september 30, 2024.
      		                            
        includes related party long-term liabilities of 0.6 million as of september 30, 2024.
      		                            
        liabilities, redeemable convertible preferred stock, and stockholders’ equity
      		                            
        short-term debt
      		                           1,020,000 
        redeemable convertible preferred stock
      		                            
        total liabilities, redeemable convertible preferred stock, and stockholders’ equity
      		                         157,291,000 159,691,000 191,845,000 
        additional paid-in-capital
      		                          245,362,000 244,089,000 
        long-term debt
      		                           18,016,000 
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 
                                   
          cash flows from operating activities:
        		                           
          net loss
        		-30,032,000 -23,812,000 -21,652,000 -20,056,000 -15,750,000 -16,425,000 -39,089,000 -12,802,000 -12,968,000 -26,584,000 -29,098,000 -23,955,000 -28,659,000 -31,068,000 -26,492,000 -27,546,000 -28,209,000 -20,199,000 -17,670,000 -14,953,000 -12,404,000 -13,341,000 -9,545,000 -9,255,000 -9,139,000 -6,645,000 -6,885,000 
          adjustments to reconcile net loss to net cash from operating activities
        		                           
          stock-based compensation expense
        		2,553,000 2,298,000 2,082,000 2,830,000 2,219,000 2,669,000 2,677,000 2,653,000 2,687,000 3,389,000 3,482,000 3,485,000 3,695,000 5,787,000 4,415,000 4,415,000 4,816,000 4,032,000 3,689,000 3,600,000 3,057,000 3,477,000 1,690,000 1,822,000 1,249,000 1,201,000 1,402,000 
          depreciation and amortization
        		2,371,000 2,462,000 2,466,000 2,531,000 2,587,000 2,543,000 2,758,000 2,803,000 2,837,000 2,907,000 2,759,000 2,849,000 2,781,000 2,956,000 1,882,000 1,820,000 1,774,000 1,601,000 1,504,000 1,386,000 1,523,000 1,479,000 1,464,000 1,419,000 1,396,000 1,366,000 1,190,000 
          noncash operating lease cost
        		161,000 131,000 405,000 401,000 398,000 363,000 350,000 349,000 337,000 -822,000 1,561,000 581,000 539,000 834,000 1,169,000 347,000 2,096,000 1,218,000 876,000 484,000 372,000 361,000 359,000 374,000 315,000   
          amortization of discount on short-term investments
        		-1,125,000 -845,000 -942,000 -1,120,000 -1,084,000                       
          other
        		21,000 -73,000 34,000 114,000 -377,000 37,000 48,000 -191,000 199,000 -61,000 -20,000 90,000 144,000 126,000 -42,000 -24,000 43,000 58,000 40,000 64,000 7,000 -3,000 106,000 21,000 -64,000 354,000 75,000 
          changes in operating assets and liabilities
        		                           
          accounts receivable
        		3,181,000 -1,827,000 -4,424,000 1,021,000 -2,833,000 5,335,000 -554,000 -1,576,000 6,385,000 -4,064,000 -3,534,000 7,970,000 -1,460,000 -3,051,000 -715,000 642,000 4,949,000 -7,934,000 -1,256,000 -1,225,000 -1,703,000 -446,000 -528,000 133,000 -2,208,000 1,144,000 2,934,000 
          inventory and other deferred costs
        		-786,000  780,000 -513,000 1,017,000 2,446,000 708,000 -436,000 1,707,000 -2,135,000 -94,000 33,000 262,000 -1,047,000 341,000 179,000 -2,455,000 -88,000 1,799,000 -1,743,000 61,000 586,000 256,000 -86,000 -1,832,000   
          prepaid expenses and other assets
        		663,000 -949,000 -142,000 97,000 -1,230,000 868,000 -608,000 1,082,000 -203,000 1,668,000 542,000 1,792,000 -254,000 841,000 -2,501,000 424,000 1,720,000 884,000 1,449,000 -5,054,000 63,000     851,000  
          accounts payable
        		-809,000 1,819,000 -990,000 1,708,000 2,013,000 -4,789,000 966,000 536,000 -5,637,000 5,927,000 604,000 54,000 -1,407,000 4,162,000 -1,153,000 -1,052,000 1,132,000 2,073,000 -3,455,000 2,100,000 -2,175,000 2,379,000 -1,280,000 -2,733,000 2,385,000 924,000 637,000 
          accrued and other current liabilities
        		-426,000 1,782,000 1,818,000 1,448,000 -2,742,000 760,000 2,352,000 2,323,000 -7,836,000 -276,000 3,375,000 -2,783,000 426,000 153,000 -1,467,000 -3,563,000 3,398,000 1,526,000 3,229,000 -3,861,000 2,471,000 2,355,000 1,971,000 -1,526,000 729,000 923,000 1,643,000 
          contract liabilities
        		2,606,000 106,000 -169,000 -339,000 -1,136,000 -478,000 -937,000 -1,108,000 -1,593,000 -264,000 513,000 704,000 4,999,000 967,000 -59,000 -3,104,000 -522,000 1,015,000 -8,494,000 -6,776,000 -2,797,000 441,000 -8,358,000 -5,456,000 -1,569,000 2,250,000 -8,140,000 
          operating lease liabilities
        		-856,000 -800,000 -1,020,000 -1,007,000 -993,000 -934,000 -870,000 -861,000 -840,000 341,000 -1,666,000 -156,000 2,375,000 2,883,000 9,973,000 -21,000 -24,000 -10,000 -133,000 -465,000 -354,000 -213,000 -141,000     
          other long-term liabilities
        		 -1,050,000 -50,000 -50,000 -50,000 650,000    0    3,000 0 0 -422,000 73,000 0 -4,000 -360,000 249,000 343,000 211,000 -83,000 -271,000 -275,000 
          net cash from operating activities
        		-22,478,000 -22,246,000 -21,804,000 -12,935,000 -17,961,000 -7,796,000 -6,198,000 -10,743,000 -20,413,000 -13,418,000 -16,681,000 -10,414,000 -15,745,000 -16,762,000 -14,765,000 -27,349,000 -11,357,000 -15,274,000 -17,880,000 -25,931,000 -11,743,000 -2,532,000 -16,124,000 -15,354,000 -8,643,000 2,405,000 -9,638,000 
          capital expenditures
        		-149,000 -53,000 -1,626,000 -290,000 -2,511,000 -1,246,000 -247,000 -6,000 -104,000 -3,524,000 -868,000 -2,741,000 -3,778,000 -9,538,000 -21,414,000 -10,310,000 -8,634,000 -3,577,000 -2,962,000 -4,105,000 -439,000 -837,000 -1,554,000 -779,000 -76,000 -1,913,000 -3,668,000 
          free cash flows
        		-22,627,000 -22,299,000 -23,430,000 -13,225,000 -20,472,000 -9,042,000 -6,445,000 -10,749,000 -20,517,000 -16,942,000 -17,549,000 -13,155,000 -19,523,000 -26,300,000 -36,179,000 -37,659,000 -19,991,000 -18,851,000 -20,842,000 -30,036,000 -12,182,000 -3,369,000 -17,678,000 -16,133,000 -8,719,000 492,000 -13,306,000 
          cash flows from investing activities:
        		                           
          purchases of available-for-sale debt securities
        		-67,040,000 -53,727,000 -48,150,000 -44,016,000 -64,281,000 -44,939,000 -38,933,000 -8,741,000 -29,095,000 -32,114,000 -47,937,000 -2,365,000 -21,529,000 -10,311,000 -21,119,000 -30,358,000 -59,702,000 -39,812,000 -20,644,000 -92,616,000 -114,056,000 -81,671,000 -12,996,000 -39,866,000 -27,242,000   
          proceeds from maturities of available-for-sale debt securities
        		24,100,000 39,425,000 68,500,000 39,935,000 44,250,000 20,000,000 11,000,000 21,500,000 35,500,000 24,000,000 40,200,000 24,655,000 39,100,000 41,700,000 58,818,000 58,230,000 65,175,000 83,300,000 53,275,000 49,616,000 26,892,000 19,368,000 20,197,000 33,030,000 27,283,000   
          purchases of property and equipment
        		-3,192,000 -77,000 -1,626,000 -290,000 -2,511,000 -1,246,000 -247,000 -6,000 -104,000 -3,524,000 -868,000 -2,741,000 -3,778,000 -9,538,000 -21,414,000 -10,310,000 -8,634,000 -3,577,000 -2,962,000 -4,105,000 -439,000 -837,000 -1,554,000 -779,000 -76,000   
          proceeds from sales of property and equipment
        		120,000     2,000 0                     
          net cash from investing activities
        		-46,012,000 -14,379,000 18,724,000 -4,371,000 -22,542,000 -26,183,000 -28,180,000 12,993,000 6,301,000 -11,638,000 -8,605,000 19,549,000 13,793,000 21,851,000 10,826,000 23,021,000 -3,161,000 39,911,000 29,669,000 -47,105,000 -82,544,000 -63,140,000 5,647,000 -7,615,000 -35,000 -34,848,000 -43,930,000 
          cash flows from financing activities:
        		                           
          proceeds from sales of common stock under atm facility, net of commissions
        		20,952,000 109,015,000 0 0 17,782,000 0 27,237,000 1,405,000 1,437,000 915,000 725,000                 
          payment of costs related to tempus and merck investment agreements
        		 -83,000 0 0 -106,000                       
          proceeds from loans
        		 0 0 0 2,587,000         0    0 0         
          repayments of loans and finance leases
        		-1,278,000                           
          payments for finance lease buyout
        		-2,125,000                           
          proceeds from issuance of common stock under equity incentive plans
        		281,000 2,247,000 94,000 672,000 132,000                       
          net cash from financing activities
        		17,830,000 110,895,000 -317,000 -327,000 20,087,000 49,601,000 62,426,000 1,516,000 1,129,000 9,816,000 290,000   511,000 760,000 -420,000 515,000 1,347,000 -506,000 6,010,000 162,849,000 941,000 118,683,000 1,321,000 323,000 471,000 -22,686,000 
          effect of exchange rates on cash, cash equivalents and restricted cash
        		9,000 2,000 -4,000 6,000 2,000 -7,000 5,000 0 -20,000 32,000 -7,000 -37,000 -4,000 6,000 -30,000 -107,000 4,000 29,000          
          net change in cash, cash equivalents and restricted cash
        		-50,651,000 74,272,000 -3,401,000 -17,627,000 -20,414,000 15,615,000 28,053,000 3,766,000 -13,003,000   10,023,000 -1,956,000 5,606,000 -3,209,000 -4,855,000 -13,999,000 26,013,000          
          cash, cash equivalents and restricted cash, beginning of period
        		126,035,000 0 0 0 93,205,000 0 0 0 58,774,000 0 0 0 90,918,000               
          cash, cash equivalents and restricted cash, end of period
        		75,384,000 74,272,000 -3,401,000 -17,627,000 72,791,000 15,615,000 28,053,000 3,766,000 45,771,000 -15,208,000 -25,003,000 10,023,000 88,962,000 5,606,000 -3,209,000 -4,855,000 93,376,000 26,013,000          
          reconciliation of cash, cash equivalents and restricted cash to the consolidated balance sheets:
        		                           
          cash and cash equivalents
        		73,594,000 74,272,000 -3,401,000 -17,627,000 71,001,000 15,615,000 28,053,000 3,766,000 43,981,000 -15,208,000 -25,003,000 10,023,000 87,172,000 5,606,000 -3,209,000 -4,855,000 91,586,000 26,013,000          
          restricted cash, included in other long-term assets
        		1,790,000 0 0 0 1,790,000 0 0 0 1,790,000 0 0 0 1,790,000 0 0 0 1,790,000 0          
          total cash, cash equivalents and restricted cash
        		75,384,000 74,272,000 -3,401,000 -17,627,000 72,791,000 15,615,000 28,053,000 3,766,000 45,771,000 -15,208,000 -25,003,000 10,023,000 88,962,000 5,606,000 -3,209,000 -4,855,000 93,376,000 26,013,000          
          supplemental cash flow information:
        		                           
          acquisition of property and equipment included in accounts payable and accrued liabilities
        		3,043,000 24,000                          
          finance lease assets were reclassified to property and equipment upon lease buyout
        		2,246,000                           
          noncash gain related to liability classified tempus warrants
        		       -2,974,000 -4,765,000                   
          inventories and other deferred costs
        		                         -1,000 -1,067,000 
          proceeds from exercise of tempus warrants
        		     0                      
          proceeds from sale of common stock under tempus investment agreement
        		     0                      
          proceeds from sale of common stock under merck investment agreement
        		                           
          repayments of loans
        		 -284,000 -411,000 -999,000 -308,000 -308,000 -308,000 -206,000 -308,000 -972,000 -435,000   0 -436,000   0 -1,042,000         
          cash paid for income taxes, net of refunds
        		                           
          finance lease assets obtained in exchange for finance lease liabilities
        		                           
          right-of-use finance lease assets obtained in exchange for finance lease liabilities
        		                           
          noncash charges related to liability classified tempus warrants
        		     0                      
          noncash restructuring and other charges
        		         3,129,000 0                 
          noncash lease impairment expense
        		         0                  
          proceeds from issuance of tempus warrants
        		                           
          amortization of premium (discount) on short-term investments
        		      -562,000 -541,000 -723,000 -600,000 -660,000 -350,000 -390,000       516,000 496,000       
          payment of costs related to tempus investment agreement
        		                           
          proceeds from exercise of equity awards
        		      114,000       511,000 2,000 1,437,000 515,000 1,347,000 536,000 1,658,000 933,000       
          reconciliation of cash, cash equivalents and restricted cash to the condensed consolidated balance sheets:
        		                           
          proceeds from sales of available-for-sale debt securities
        		                 0 0 0 5,059,000       
          proceeds from public offerings, net of underwriting discounts and commissions
        		                 0 0 0 162,258,000 0      
          payments of costs related to public offerings
        		                 0 0 0 -342,000 -342,000      
          cash paid for interest
        		                           
          proceeds from issuance of common stock under employee equity plans
        		          0                 
          net decrease in cash, cash equivalents and restricted cash
        		                           
          lease incentive cash receipts
        		                           
          restructuring and other charges
        		            1,204,000               
          amortization of premium on short-term investments
        		             -308,000 -116,000 134,000 347,000           
          cash, cash equivalents, and restricted cash, beginning of period
        		              0 0 107,375,000           
          loss on debt extinguishment
        		                         0  
          change in fair value of convertible preferred stock warrant liability
        		                         0 0 
          payments of loan costs
        		                           
          debt extinguishment costs
        		                         0  
          cash and cash equivalents, beginning of period
        		                 0 0 0 68,525,000 0 0 0 55,046,000 0 0 
          effect of exchange rates on cash flows and cash equivalents
        		                   17,000 2,000 11,000 -3,000 -4,000 3,000 5,000 -2,000 
          net change in cash and cash equivalents
        		                   -67,009,000 68,564,000 -64,720,000 108,203,000 -21,652,000 -8,352,000   
          cash and cash equivalents, end of period
        		                   -67,009,000 137,089,000 -64,720,000 108,203,000 -21,652,000 46,694,000 -31,967,000 -76,256,000 
          change in fair value of compound derivative instrument
        		                           
          accretion of noncash interest and debt reduction
        		                         0 53,000 
          prepaid expenses and other current assets
        		                     -247,000 -2,461,000 218,000 178,000   
          proceeds from exercise or settlement of equity awards
        		                     1,283,000 1,276,000     
          proceeds from borrowings
        		                         0 0 
          payments of borrowing costs
        		                         0 0 
          repayments under borrowing arrangements
        		                         0 -20,000,000 
          supplemental disclosures of cash flow information:
        		                           
          income taxes paid
        		                           
          supplemental disclosures of noncash investing and financing activities:
        		                           
          convertible notes conversion on september 20, 2018
        		                           
          proceeds from exercise of common stock warrants
        		                          0 
          proceeds from initial public offering, net of underwriting discounts and commissions
        		                         0 0 
          payments of costs related to initial public offering
        		                           
          proceeds from exercise of stock options
        		                        323,000 34,000 67,000 
          purchase of available-for-sale debt securities
        		                         -38,635,000  
          purchase of property and equipment
        		                         -1,913,000 -3,668,000 
          payment of costs related to initial public offering
        		                         -247,000 -1,959,000 
          proceeds from issuance of common stock under espp
        		                           
          net increase in cash and cash equivalents
        		                         -31,967,000 -76,256,000 
          noncash lease expense
        		                          244,000 
          payment of costs related to issuance of series c redeemable convertible preferred stock