Pacific Biosciences of California, Inc
(NASDAQ:PACB)

Pacific Biosciences of California, Inc. designs, develops, and manufactures sequencing systems to resolve genetically complex problems. The company provides PacBio's Systems, which conduct, monitor, and analyse biochemical sequencing reactions; consumable products, including single molecule real-tim...

Website: http://www.pacb.com

Founded: 2004

Full Time Employees: 404

Sector: Healthcare

Industry: Diagnostics & Research

Pharmaceuticals Genomics

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Unit: USD	2026-03-31	2025-12-31	2025-09-30	2025-06-30	2025-03-31	2024-12-31	2024-09-30	2024-06-30	2024-03-31	2023-12-31	2023-09-30	2023-06-30	2023-03-31	2022-12-31	2022-09-30	2022-06-30	2022-03-31	2021-12-31	2021-09-30	2021-06-30	2021-03-31	2020-12-31	2020-09-30	2020-06-30	2020-03-31	2019-12-31	2019-09-30	2019-06-30	2019-03-31	2018-12-31	2018-09-30	2018-06-30	2018-03-31	2017-12-31	2017-09-30	2017-06-30	2017-03-31	2016-12-31	2016-09-30	2016-06-30	2016-03-31	2015-12-31	2015-09-30	2015-06-30	2015-03-31	2014-12-31	2014-09-30	2014-06-30	2014-03-31	2013-12-31	2013-09-30	2013-06-30	2013-03-31	2012-12-31	2012-09-30	2012-06-30	2012-03-31	2011-12-31	2011-09-30	2011-07-14	2011-06-30	2011-03-31	2010-12-31	2010-09-30	2010-07-14

revenue:
product revenue	31,534,000	38,965,000	32,597,000	33,083,000	31,113,000	34,098,000	35,296,000	31,746,000	35,009,000	54,001,000	51,562,000	43,655,000	34,654,000	22,771,000	27,509,000	30,175,000	28,244,000	31,167,000	30,502,000	26,533,000	25,303,000	23,626,000	15,749,000	13,756,000	12,293,000	77,692,083	18,484	21,250	13,457,000	16,438,000	15,150,000	18,485,000	16,282,000		20,343,000	16,548,000	21,294,000		18,050	13,587	12,379		7,570	8,825	11,308,000		6,762	7,749	7,865,000		5,814,000	4,601,000	3,833,000		1,268,000	5,827,000	8,715,000		9,819,000		10,148,000
service and other revenue	5,644,000	5,680,000	5,844,000	6,683,000	6,040,000	5,126,000	4,671,000	4,267,000	3,801,000	4,356,000	4,129,000	3,918,000	4,246,000	4,582,000	4,802,000	5,292,000	4,929,000	4,852,000	4,385,000	4,077,000	3,694,000	3,510,000	3,333,000	3,321,000	3,305,000	13,139,817	3,431	3,371	2,968,000	3,088,000	3,010,000	3,093,000	3,080,000		3,202,000	3,525,000	3,621,000		3,472	3,564	3,152		2,751	2,518	2,741,000		2,165	1,980	2,081,000		1,607,000	1,447,000	1,475,000		1,283,000	1,284,000	1,053,000		535,000		192,000
total revenue	37,178,000	44,645,000	38,441,000	39,766,000	37,153,000	39,224,000	39,967,000	36,013,000	38,810,000	58,357,000	55,691,000	47,573,000	38,900,000	27,353,000	32,311,000	35,467,000	33,173,000	36,019,000	34,887,000	30,610,000	28,997,000	27,136,000	19,082,000	17,077,000	15,598,000	90,831,900	21,915	24,621	16,425,000	19,526,000	18,160,000	21,578,000	19,362,000		23,545,000	20,073,000	24,915,000		25,118	20,747	19,127		13,917	24,939	17,645,000		20,623	11,425	11,642,000		7,421,000	6,048,000	5,578,000		2,776,000	7,291,000	10,038,000		10,519,000		10,630,000
yoy	0.07%	13.82%	-3.82%	10.42%	-4.27%	-32.79%	-28.23%	-24.30%	-0.23%	113.35%	72.36%	34.13%	17.26%	-24.06%	-7.38%	15.87%	14.40%	32.74%	82.83%	79.25%	85.90%	-70.13%	86972.78%	69259.49%	-5.04%	365.18%	-99.88%	-99.89%	-15.17%		-22.87%	7.50%	-22.29%		93637.56%	96651.34%	130160.89%		80.48%	-16.81%	-99.89%		-32.52%	118.28%	51.56%		-99.72%	-99.81%	108.71%		167.33%	-17.05%	-44.43%		-73.61%		-5.57%
qoq	-16.73%	16.14%	-3.33%	7.03%	-5.28%	-1.86%	10.98%	-7.21%	-33.50%	4.79%	17.06%	22.30%	42.21%	-15.34%	-8.90%	6.92%	-7.90%	3.24%	13.97%	5.56%	6.86%	42.21%	11.74%	9.48%	-82.83%	414373.65%	-10.99%	-99.85%	-15.88%	7.52%	-15.84%	11.45%			17.30%	-19.43%			21.07%	8.47%			-44.20%	-99.86%			80.51%	-99.90%			22.70%	8.43%			-61.93%	-27.37%
cost of revenue:
cost of product revenue	19,972,000	24,204,000	19,204,000	20,022,000	26,333,000	23,476,000	23,278,000	23,083,000	22,447,000	39,871,000	33,735,000	28,432,000	25,164,000	15,045,000	15,568,000	15,499,000	14,820,000	14,909,000	15,530,000	13,222,000	12,697,000	12,550,000	9,228,000	8,225,000	5,421,000	44,739,873	12,188	11,980	8,618,000	10,926,000	12,250,000	9,858,000	9,019,000		11,547,000	8,155,000	11,362,000		9,273	7,115	6,880		5,119	8,438	9,732,000		5,608	6,271	7,169,000		4,616,000	3,322,000	3,200,000		960,000	5,382,000	8,607,000		6,546,000		2,537,000
cost of service and other revenue	4,182,000	3,681,000	3,078,000	4,853,000	3,778,000	3,469,000	3,484,000	3,366,000	3,738,000	3,496,000	4,054,000	3,412,000	3,792,000	3,280,000	3,012,000	3,592,000	4,015,000	4,161,000	3,870,000	3,635,000	3,323,000	3,185,000	2,790,000	2,239,000	2,689,000	11,535,377	2,813	3,028	2,690,000	2,854,000	2,718,000	2,858,000	3,047,000		3,771,000	3,917,000	4,616,000		3,207	2,988	2,743		2,247	1,995	1,986,000		1,853	2,028	1,797,000		1,564,000	1,667,000	1,448,000		1,626,000	1,634,000	1,583,000		645,000		194,000
amortization of acquired intangible assets	183,000	183,000	183,000	183,000	4,345,000	2,221,000	3,201,000	2,628,000	1,343,000	1,242,000	741,000
loss on purchase commitment		11,000	75,000	24,000	4,068,000			998,000
total cost of revenue	24,337,000	28,079,000	22,540,000	25,082,000	38,524,000	29,166,000	29,963,000	30,075,000	27,528,000	48,786,000	37,789,000	32,027,000	29,139,000	22,213,000	18,764,000	19,274,000	19,018,000	19,253,000	19,523,000	16,857,000	16,020,000	15,735,000	12,018,000	10,464,000	8,110,000	56,275,250	15,001	15,008	11,308,000	13,780,000	14,968,000	12,716,000	12,066,000		15,318,000	12,072,000	15,978,000		12,480	10,103	9,623		7,366	10,433	11,718,000		7,461	8,299	8,966,000		6,180,000	4,989,000	4,648,000		2,586,000	7,016,000	10,190,000		7,191,000		2,731,000
gross profit	12,841,000	16,566,000	15,901,000	14,684,000	-1,371,000	10,058,000	10,004,000	5,938,000	11,282,000	9,571,000	17,902,000	15,546,000	9,761,000	5,140,000	13,547,000	16,193,000	14,155,000	16,766,000	15,364,000	13,753,000	12,977,000	11,401,000	7,064,000	6,613,000	7,488,000	34,556,650	6,914	9,613	5,117,000	5,746,000	3,192,000	8,862,000	7,296,000		8,227,000	8,001,000	8,937,000		12,638	10,644	9,504		6,551	14,506	5,927,000		13,162	3,126	2,676,000		1,241,000	1,059,000	930,000		190,000	275,000	-152,000		3,328,000		7,899,000
yoy	-1036.62%	64.70%	58.95%	147.29%	-112.15%	5.09%	-44.12%	-61.80%	15.58%	86.21%	32.15%	-4.00%	-31.04%	-69.34%	-11.83%	17.74%	9.08%	47.06%	117.50%	107.97%	73.30%	-67.01%	102069.51%	68692.26%	46.34%	501.40%	-99.78%	-99.89%	-29.87%		-61.20%	10.76%	-18.36%		64997.33%	75069.11%	93934.09%		92.92%	-26.62%	-99.84%		-50.23%	364.04%	121.49%		-98.94%	-99.70%	187.74%		553.16%	285.09%	-711.84%		-94.29%		-101.92%
qoq	-22.49%	4.18%	8.29%	-1171.04%	-113.63%	0.54%	68.47%	-47.37%	17.88%	-46.54%	15.16%	59.27%	89.90%	-62.06%	-16.34%	14.40%	-15.57%	9.13%	11.71%	5.98%	13.82%	61.40%	6.82%	-11.69%	-78.33%	499706.91%	-28.08%	-99.81%	-10.95%	80.01%	-63.98%	21.46%			2.82%	-10.47%			18.73%	11.99%			-54.84%	-99.76%			321.05%	-99.88%			17.19%	13.87%			-30.91%	-280.92%
gross margin %	34.54%	37.11%	41.36%	36.93%	-3.69%	25.64%	25.03%	16.49%	29.07%	16.40%	32.15%	32.68%	25.09%	18.79%	41.93%	45.66%	42.67%	46.55%	44.04%	44.93%	44.75%	42.01%	37.02%	38.72%	48.01%	38.04%	31.55%	39.04%	31.15%	29.43%	17.58%	41.07%	37.68%	NaN%	34.94%	39.86%	35.87%	NaN%	50.31%	51.30%	49.69%	NaN%	47.07%	58.17%	33.59%	NaN%	63.82%	27.36%	22.99%	NaN%	16.72%	17.51%	16.67%	NaN%	6.84%	3.77%	-1.51%	NaN%	31.64%	NaN%	74.31%	NaN%	NaN%	NaN%
operating expense:
research and development	19,608,000	22,879,000	22,846,000	22,529,000	29,053,000	27,466,000	25,516,000	38,485,000	43,455,000	44,544,000	47,514,000	46,173,000	48,939,000	42,623,000	47,092,000	50,348,000	52,937,000	42,576,000	27,508,000	22,266,000	20,548,000	17,425,000	16,467,000	15,010,000	15,250,000	59,583,669	14,962	14,910	15,485,000	16,263,000	14,356,000	15,664,000	16,311,000		15,844,000	16,883,000	16,971,000		17,479	17,522	16,361		16,162	15,043	14,483,000		11,693	12,435	11,771,000		10,419,000	11,682,000	11,983,000		12,626,000	11,272,000	12,073,000		20,001,000	290,269,000	19,546,000	24,118,000		32,873,000
sales, general and administrative	31,153,000	34,051,000	31,099,000	36,175,000	40,168,000	41,641,000	43,746,000	45,877,000	43,753,000	45,996,000	43,431,000	40,573,000	39,818,000	45,003,000	36,795,000	39,252,000	39,804,000	37,320,000	31,606,000	29,060,000	26,139,000	17,953,000	14,772,000	15,127,000	24,947,000	75,447,617	20,066	19,083	19,766,000	20,106,000	13,506,000	14,943,000	14,934,000		13,952,000	15,505,000	15,265,000		11,894	11,192	11,708		10,818	10,821	10,772,000		9,882	8,993	9,150,000		10,757,000	9,374,000	9,554,000		10,143,000	11,558,000	15,285,000		12,764,000	76,554,000	11,016,000	11,119,000		8,043,000
impairment charges					15,000,000
settlement charges	15,400,000
gain on disposal of assets	-45,796,000
change in fair value of contingent consideration					-18,700,000	-1,950,000	1,170,000		-70,000	1,100,000	-271,000	1,975,000	12,256,000	4,598,000	4,280,000	-5,438,000	-1,063,000
total operating expense	21,198,000	57,763,000	54,778,000	59,537,000	427,563,000	163,086,000	74,081,000	181,784,000	92,644,000	97,119,000	100,394,000	88,721,000	101,013,000	92,224,000	88,167,000	84,162,000	91,678,000	81,442,000	89,840,000	51,326,000	46,687,000	35,378,000	31,239,000	30,137,000	40,197,000	135,031,286	35,028	33,993	35,251,000	36,369,000	27,862,000	30,607,000	31,245,000		29,796,000	32,388,000	32,236,000		29,373	28,714	28,069		3,937	25,864	25,255,000		21,575	21,428	20,921,000		21,176,000	21,056,000	21,537,000		22,769,000	22,830,000	27,358,000		32,765,000		30,562,000
operating income	-8,357,000	-41,197,000	-38,877,000	-44,853,000	-428,934,000	-153,028,000	-64,077,000	-175,846,000	-81,362,000	-87,548,000	-82,492,000	-73,175,000	-91,252,000	-87,084,000	-74,620,000	-67,969,000	-77,523,000	-64,676,000	-74,476,000	-37,573,000	-33,710,000	-23,977,000	-24,175,000	-23,524,000	-32,709,000	-100,474,636	-28,114	-24,380	-30,134,000	-30,623,000	-24,670,000	-21,745,000	-23,949,000		-21,569,000	-24,387,000	-23,299,000		-16,735	-18,070	-18,565		2,614	-11,358	-19,328,000		-8,413	-18,302	-18,245,000		-19,935,000	-19,997,000	-20,607,000		-22,579,000	-22,555,000	-27,510,000		-29,437,000		-22,663,000
yoy	-98.05%	-73.08%	-39.33%	-74.49%	427.19%	74.79%	-22.32%	140.31%	-10.84%	0.53%	10.55%	7.66%	17.71%	34.65%	0.19%	80.90%	129.97%	169.74%	208.07%	59.72%	3.06%	-76.14%	85889.19%	96388.93%	8.55%	228.10%	-99.89%	-99.89%	25.83%		14.38%	-10.83%	2.79%		128785.57%	134858.49%	125399.60%		-740.21%	59.09%	-99.90%		-131.07%	-37.94%	5.94%		-99.96%	-99.91%	-11.46%		-11.71%	-11.34%	-25.09%		-23.30%		21.39%
qoq	-79.71%	5.97%	-13.32%	-89.54%	180.30%	138.82%	-63.56%	116.13%	-7.07%	6.13%	12.73%	-19.81%	4.79%	16.70%	9.79%	-12.32%	19.86%	-13.16%	98.22%	11.46%	40.59%	-0.82%	2.77%	-28.08%	-67.45%	357282.93%	15.32%	-99.92%	-1.60%	24.13%	13.45%	-9.20%			-11.56%	4.67%			-7.39%	-2.67%			-123.01%	-99.94%			-54.03%	-99.90%			-0.31%	-2.96%			0.11%	-18.01%
operating margin %	-22.48%	-92.28%	-101.13%	-112.79%	-1154.51%	-390.14%	-160.32%	-488.28%	-209.64%	-150.02%	-148.12%	-153.82%	-234.58%	-318.37%	-230.94%	-191.64%	-233.69%	-179.56%	-213.48%	-122.75%	-116.25%	-88.36%	-126.69%	-137.75%	-209.70%	-110.62%	-128.29%	-99.02%	-183.46%	-156.83%	-135.85%	-100.77%	-123.69%	NaN%	-91.61%	-121.49%	-93.51%	NaN%	-66.63%	-87.10%	-97.06%	NaN%	18.78%	-45.54%	-109.54%	NaN%	-40.79%	-160.19%	-156.72%	NaN%	-268.63%	-330.64%	-369.43%	NaN%	-813.36%	-309.35%	-274.06%	NaN%	-279.85%	NaN%	-213.20%	NaN%	NaN%	NaN%
interest expense	-1,740,000	-1,740,000	-1,739,000	-1,738,000	-1,737,000	-2,757,000	-3,538,000	-3,542,000	-3,575,000	-3,571,000	-3,588,000	-3,554,000	-3,630,000	-3,648,000	-3,664,000	-3,681,000	-3,697,000	-3,479,000	-3,673,000	-3,589,000	-1,789,000				-267,000	-2,609,205	-664	-644	-625,000	-628,000	-616,000	-598,000	-581,000		-633,000	-826,000	-838,000		-821	-795	-779		-741	-715	-697,000		-716	-701	-686,000		-686,000	-673,000
other income	2,006,000	2,768,000	2,999,000	4,696,000	4,294,000	4,065,000	6,890,000	6,069,000	6,759,000	8,383,000	8,505,000	8,929,000	6,867,000	6,348,000	1,313,000	256,000	-279,000	1,000	-133,000	161,000	64,000	912,000	467,000	438,000	238,000	1,021,604	-345	428	435,000	452,000	242,000	-197,000	351,000		181,000	-326,000	270,000		62	366				138	-148,000		-34	-133	45,000		134,000	199,000	-497,000		-150,000	68,000	-70,000		156,000	-484,000	188,000			-9,000
income before income taxes	-8,091,000	-40,169,000	-37,617,000	-41,895,000
income tax provision	184,000	202,000	383,000	35,000	-302,000
net income	-8,275,000	-40,371,000	-38,000,000	-41,930,000	-426,075,000	2,371,000	-60,725,000	-173,319,000	-78,178,000	-82,018,000	-66,869,000	-69,833,000	-88,015,000	-84,384,000	-76,971,000	-71,394,000	-81,499,000	-69,329,000	16,542,000	-41,001,000	-87,435,000	74,935,000	-23,708,000	-23,086,000	1,262,000	-84,062,237	-29,123	-24,596	-30,324,000	-30,799,000	-25,044,000	-22,540,000	-24,179,000		-22,021,000	-25,539,000	-23,867,000		-17,494	-18,499	-19,352		1,821	-11,935	-20,173,000		-9,163	-19,136	-18,886,000		-20,487,000	-20,471,000	-21,104,000		-22,729,000	-22,487,000	-27,580,000		-29,281,000	-354,162,000	-22,475,000	-34,809,000		-40,708,000
yoy	-98.06%	-1802.70%	-37.42%	-75.81%	445.01%	-102.89%	-9.19%	148.19%	-11.18%	-2.80%	-13.12%	-2.19%	8.00%	21.72%	-565.31%	74.13%	-6.79%	-192.52%	-169.77%	77.60%	-7028.29%	-189.14%	81306.45%	93760.79%	-104.16%	172.94%	-99.88%	-99.89%	25.41%		13.73%	-11.74%	1.31%		125777.44%	137956.11%	123230.92%		-1060.68%	55.00%	-99.90%		-119.87%	-37.63%	6.81%		-99.96%	-99.91%	-10.51%		-9.86%	-8.97%	-23.48%		-22.38%	-93.65%	22.71%			770.01%
qoq	-79.50%	6.24%	-9.37%	-90.16%	-18070.27%	-103.90%	-64.96%	121.70%	-4.68%	22.65%	-4.24%	-20.66%	4.30%	9.63%	7.81%	-12.40%	17.55%	-519.11%	-140.35%	-53.11%	-216.68%	-416.07%	2.69%	-1929.32%	-101.50%	288545.53%	18.41%	-99.92%	-1.54%	22.98%	11.11%	-6.78%			-13.78%	7.01%			-5.43%	-4.41%			-115.26%	-99.94%			-52.12%	-99.90%			0.08%	-3.00%			1.08%	-18.47%			-91.73%	1475.80%	-35.43%
net income margin %	-22.26%	-90.43%	-98.85%	-105.44%	-1146.81%	6.04%	-151.94%	-481.27%	-201.44%	-140.55%	-120.07%	-146.79%	-226.26%	-308.50%	-238.22%	-201.30%	-245.68%	-192.48%	47.42%	-133.95%	-301.53%	276.15%	-124.24%	-135.19%	8.09%	-92.55%	-132.89%	-99.90%	-184.62%	-157.73%	-137.91%	-104.46%	-124.88%	NaN%	-93.53%	-127.23%	-95.79%	NaN%	-69.65%	-89.16%	-101.18%	NaN%	13.08%	-47.86%	-114.33%	NaN%	-44.43%	-167.49%	-162.22%	NaN%	-276.07%	-338.48%	-378.34%	NaN%	-818.77%	-308.42%	-274.76%	NaN%	-278.36%	-Infinity%	-211.43%	-Infinity%	NaN%	-Infinity%
other comprehensive loss:
unrealized loss on investments	-604,000			-114,000	-41,000											-1,372,000	-2,998,000
comprehensive loss	-8,879,000	-40,329,000	-37,852,000	-42,044,000	-426,116,000	1,240,000	-58,649,000	-173,536,000	-78,703,000	-79,959,000	-66,023,000	-70,595,000	-85,174,000			-72,766,000	-84,497,000			-41,081,000		-11,354,750	-23,833,000	-22,873,000		-84,021,245	-29,129	-24,585	-30,282,000	-30,811,000	-25,052,000	-22,518,000	-24,185,000		-22,007,000	-25,552,000	-23,875,000			-18,488	-19,304			-11,939	-20,166,000		-9,182	-19,112	-18,882,000		-20,474,000	-20,484,000	-21,123,000		-22,738	-22,547	-27,502
net income per share
basic	-0.03	-0.13	-0.13	-0.14	-1.44	0.02	-0.22	-0.64	-0.29	-0.31	-0.26	-0.28	-0.36	-0.37	-0.34	-0.32	-0.37	-0.33	0.08	-0.21	-0.45				0.01														-0.19				0.02
diluted	-0.03	-0.13	-0.13	-0.14	-1.44	-0.44	-0.22	-0.64	-0.29	-0.31	-0.26	-0.28	-0.36	-0.37	-0.34	-0.32	-0.37	-0.33	0.08	-0.21	-0.45				0.01														-0.19				0.02
weighted-average shares outstanding used in calculating net loss per share:
basic	305,819	299,959	300,844	300,162	296,858	274,488	272,915	272,385	269,578	253,629	255,001	250,070	242,032	224,550	225,123	224,499	222,289	204,136	202,194	198,568	194,790	165,187			153,453														92,110				75,205
diluted	305,819	299,959	300,844	300,162	296,858	288,366	272,915	272,385	269,578	253,629	255,001	250,070	242,032	224,550	225,123	224,499	222,289	204,136	215,127	198,568	194,790	174,970			155,855														92,110				80,479
other comprehensive income:
unrealized gain on investments		42,000	148,000			-1,131,000	2,076,000	-217,000	-525,000	2,059,000	846,000	-762,000	2,841,000	1,495,000	-803,000										25,000										14,000	-13,000			-29	11	48				7,000		-19	24	4,000		13,000	-13,000	-19,000
loss before benefit from income taxes					-426,377,000	-78,055,500	-60,725,000	-173,319,000	-78,178,000	-82,736,000	-77,575,000			-57,466,000	-76,971,000			-51,679,500	-78,282,000
goodwill impairment						23,300,000		93,200,000
merger-related expenses										63,000	8,979,000							403,000	30,726,000
loss on extinguishment of debt												-2,033,000
benefit from income taxes										-718,000	-10,706,000							1,175,000	-94,824,000
amortization of intangible assets												183,000	183,000	183,000	184,000	183,000	183,000	183,000	123,000
income before benefit from income taxes												-69,833,000
weighted-average shares outstanding used in calculating net income per share:
basic	305,819	299,959	300,844	300,162	296,858	274,488	272,915	272,385	269,578	253,629	255,001	250,070	242,032	224,550	225,123	224,499	222,289	204,136	202,194	198,568	194,790	165,187			153,453														92,110				75,205
diluted	305,819	299,959	300,844	300,162	296,858	288,366	272,915	272,385	269,578	253,629	255,001	250,070	242,032	224,550	225,123	224,499	222,289	204,136	215,127	198,568	194,790	174,970			155,855														92,110				80,479
loss before expense from income taxes													-88,015,000
expense from income taxes
loss from continuation advances
comprehensive income														-82,889,000	-77,774,000			-70,443,000	16,575,000		-87,446,000				1,287,000														-17,523				1,815
loss from continuation advances from illumina
gain from continuation advances																		-13,000,000			-52,000,000	8,500,000			34,000,000
unrealized income on investments																		-14,500	33,000	-80,000	-11,000	28,250	-125,000	213,000		2		11	42,000	2,000		22,000
weighted-average shares outstanding used in computing net income per share
basic	305,819	299,959	300,844	300,162	296,858	274,488	272,915	272,385	269,578	253,629	255,001	250,070	242,032	224,550	225,123	224,499	222,289	204,136	202,194	198,568	194,790	165,187			153,453														92,110				75,205
diluted	305,819	299,959	300,844	300,162	296,858	288,366	272,915	272,385	269,578	253,629	255,001	250,070	242,032	224,550	225,123	224,499	222,289	204,136	215,127	198,568	194,790	174,970			155,855														92,110				80,479
weighted-average shares outstanding used in computing net loss per share
basic	305,819	299,959	300,844	300,162	296,858	274,488	272,915	272,385	269,578	253,629	255,001	250,070	242,032	224,550	225,123	224,499	222,289	204,136	202,194	198,568	194,790	165,187			153,453														92,110				75,205
diluted	305,819	299,959	300,844	300,162	296,858	288,366	272,915	272,385	269,578	253,629	255,001	250,070	242,032	224,550	225,123	224,499	222,289	204,136	215,127	198,568	194,790	174,970			155,855														92,110				80,479
net income per share
basic and diluted net loss per share																						-0.073	-0.14	-0.15			-0.19	-0.16	-0.2	-0.21	-0.19	-0.17	-0.2		-0.19	-0.26	-0.26			-0.21	-0.23			-0.16	-0.27		-0.13	-0.27	-0.28		-0.31	-0.33	-0.37		-0.41	-0.4	-0.5		-0.54		-0.42
shares used in computing basic and diluted net loss per share																						39,548.75	166,862	154,172		22,225	152,983	152,776	151,274	4,792	135,130	131,882	123,768			97,360	92,970			88,148	83,604			74,733	74,149		70,740	70,515	67,861		65,523	61,922	57,372		55,877	55,658			54,283,162		53,413,565
weighted-average shares outstanding used in calculating net income per share
basic	305,819	299,959	300,844	300,162	296,858	274,488	272,915	272,385	269,578	253,629	255,001	250,070	242,032	224,550	225,123	224,499	222,289	204,136	202,194	198,568	194,790	165,187			153,453														92,110				75,205
diluted	305,819	299,959	300,844	300,162	296,858	288,366	272,915	272,385	269,578	253,629	255,001	250,070	242,032	224,550	225,123	224,499	222,289	204,136	215,127	198,568	194,790	174,970			155,855														92,110				80,479
contractual revenue																																							3,596	3,596	3,596		3,596	13,596	3,596,000		11,696	1,696	1,696,000
shares used in computing basic and diluted net loss per share																																			115,771
gain on lease amendments																																											-23,043
other expense																																											-52																			-13,000
grant revenue																																																					270,000		225,000	180,000	270,000		165,000	8,868,000	290,000	270,000
shares used in computing basic and diluted net loss per share basic and diluted net loss per share																																																									55,201
operating expenses
total operating expenses																																																												366,823,000		35,237,000		40,916,000
income from operations																																																												-357,955,000		-34,967,000		-40,696,000
interest income																																																												4,277,000		171,000		-3,000
basic and diluted net income per share of common stock
shares used to calculate basic and diluted net income per share
basic and diluted net loss per share of common stock																																																														-0.66		-39.7
shares used to calculate basic and diluted net loss per share																																																														52,756,116		1,025,326
revenue																																																																220,000

Balance Sheets:

Quarterly

Annual

Unit: USD	2026-03-31	2025-12-31	2025-09-30	2025-06-30	2025-03-31	2024-12-31	2024-09-30	2024-06-30	2024-03-31	2023-12-31	2023-09-30	2023-06-30	2023-03-31	2022-12-31	2022-09-30	2022-06-30	2022-03-31	2021-12-31	2021-09-30	2021-06-30	2021-03-31	2020-12-31	2020-09-30	2020-06-30	2020-03-31	2019-12-31	2019-09-30	2019-06-30	2019-03-31	2018-12-31	2018-09-30	2018-06-30	2018-03-31	2017-12-31	2017-09-30	2017-06-30	2017-03-31	2016-12-31	2016-09-30	2016-06-30	2016-03-31	2015-12-31	2015-09-30	2015-06-30	2015-03-31	2014-12-31	2014-09-30	2014-06-30	2014-03-31	2013-12-31	2013-09-30	2013-06-30	2013-03-31	2012-12-31	2012-09-30	2012-06-30	2012-03-31	2011-12-31	2011-09-30	2011-06-30	2011-03-31	2010-12-31	2010-09-30

assets
current assets
cash and cash equivalents	56,274,000	63,707,000	56,467,000	54,803,000	58,507,000	55,370,000	77,982,000	99,526,000	76,646,000	179,911,000	385,648,000	209,287,000	353,834,000	325,089,000	304,433,000	310,445,000	428,574,000	460,725,000	425,388,000	459,794,000	932,398,000	81,611,000	69,028,000	43,342,000	68,862,000	29,627,000	33,084,000	30,358,000	38,205,000	18,844,000	38,063,000	23,058,000	25,458,000	16,507,000	25,931,000	36,478,000	28,982,000	16,765,000	22,794,000	24,778,000	20,080,000	33,629,000	27,208,000	25,930,000	30,271,000	36,449,000	35,411,000	28,200,000	41,261,000	26,362,000	64,767,000	40,833,000	53,038,000	46,540,000	32,558,000	33,623,000	56,260,000	58,865,000	57,580,000	54,514,000	84,615,000	147,650,000	62,717,000
investments	219,688,000	215,799,000	242,187,000	259,932,000	284,603,000	334,561,000	393,165,000	410,276,000	485,268,000	451,505,000	382,141,000	620,575,000	521,058,000	447,229,000	529,907,000	588,706,000	534,201,000	583,675,000	654,502,000	684,579,000	227,921,000	237,203,000	139,522,000	76,621,000	73,729,000	19,472,000	16,120,000	36,486,000	44,667,000	83,510,000	77,684,000	40,433,000	53,802,000	46,365,000	58,034,000	66,118,000	27,068,000	55,213,000	64,539,000	77,692,000	71,451,000	48,641,000	31,701,000	46,744,000	48,878,000	64,899,000	63,901,000	76,834,000	77,475,000	86,166,000	62,169,000	66,135,000	59,267,000	54,040,000	86,844,000	103,485,000	105,089,000	118,569,000	136,116,000	162,074,000	163,933,000	136,024,000	50,215,000
accounts receivable	29,350,000	35,448,000	30,616,000	32,257,000	31,645,000	27,524,000	29,383,000	32,433,000	30,323,000	36,615,000	30,486,000	24,034,000	29,589,000	18,786,000	22,756,000	27,058,000	27,852,000	24,241,000	23,946,000	19,936,000	12,906,000	16,837,000	11,806,000	11,346,000	7,325,000	15,266,000	9,966,000	12,123,000	7,279,000	8,595,000	6,404,000	7,446,000	8,452,000	13,433,000	8,897,000	9,525,000	10,441,000	11,421,000	11,761,000	10,427,000	8,009,000	5,245,000	4,164,000	3,950,000	5,287,000	3,406,000	2,370,000	4,255,000	3,383,000	2,746,000	3,814,000	4,104,000	2,009,000	2,822,000	532,000	3,371,000	1,505,000	4,557,000	4,434,000	5,437,000	59,000	341,000	1,052,000
inventory	51,022,000	49,285,000	53,153,000	53,839,000	54,007,000	58,755,000	65,737,000	68,594,000	67,343,000	56,676,000	68,256,000	67,608,000	61,955,000	50,381,000	43,495,000	36,121,000	29,625,000	24,599,000	18,276,000	17,985,000	16,268,000	14,230,000	15,940,000	16,768,000	16,124,000	13,312,000	15,067,000	17,404,000	19,650,000	17,878,000	19,694,000	23,440,000	25,930,000	23,065,000	18,201,000	17,266,000	15,348,000	15,634,000	16,473,000	14,201,000	12,162,000	10,955,000	11,621,000	11,978,000	13,457,000	11,335,000	11,398,000	9,440,000	8,301,000	10,050,000	9,819,000	10,283,000	10,597,000	9,592,000	10,202,000	10,271,000	11,821,000	15,517,000	20,262,000	19,552,000	13,539,000	6,864,000
prepaid expenses and other current assets	13,164,000	10,793,000	11,513,000	12,266,000	15,471,000	18,781,000	17,277,000	16,968,000	17,144,000	17,040,000	15,466,000	13,748,000	14,375,000	10,289,000	13,005,000	7,657,000	8,436,000	7,394,000	7,193,000	6,542,000	5,623,000	4,870,000	3,212,000	2,862,000	3,490,000	3,369,000	2,704,000	2,538,000	2,787,000	2,832,000	2,028,000	2,035,000	2,057,000	2,249,000	2,548,000	3,545,000	6,501,000	9,978,000	6,900,000	10,957,000	7,351,000	12,071,000	11,513,000	1,587,000	1,629,000	1,671,000	1,057,000	1,169,000	1,642,000	1,135,000	1,194,000	759,000	1,570,000	2,006,000	2,202,000	1,893,000	2,131,000	2,093,000	1,891,000	3,151,000	2,124,000	2,235,000	3,302,000
short-term restricted cash	19,000	20,000	300,000	300,000	690,000	690,000	690,000	342,000	300,000	300,000	300,000	300,000	300,000	300,000	300,000	300,000	500,000	500,000	500,000	300,000	836,000	836,000
total current assets	369,517,000	375,052,000	394,236,000	413,397,000	444,923,000	495,681,000	584,234,000	628,139,000	677,024,000	742,047,000	882,297,000	935,552,000	981,111,000	852,074,000	913,896,000	970,287,000	1,029,188,000	1,101,134,000	1,129,805,000	1,189,136,000	1,195,952,000	355,587,000	239,508,000	150,939,000	169,530,000	81,046,000	76,941,000	98,909,000	112,588,000	131,659,000	143,873,000	96,412,000	115,699,000	101,619,000	113,611,000	132,932,000	88,340,000	109,011,000	122,467,000	138,055,000	119,053,000	110,541,000	86,207,000	90,189,000	99,522,000	117,760,000	114,137,000	119,898,000	132,062,000	126,459,000	141,763,000	122,114,000	126,481,000	115,000,000	132,338,000	152,643,000	176,806,000	199,601,000	220,283,000	244,728,000	264,270,000	293,114,000	117,286,000
property and equipment	24,376,000	24,146,000	22,127,000	23,102,000	24,794,000	30,505,000	31,952,000	34,910,000	37,291,000	36,432,000	40,340,000	40,317,000	40,833,000	41,580,000	39,154,000	37,957,000	35,510,000	32,504,000	31,119,000	25,000,000	24,207,000	24,899,000	26,568,000	27,733,000	29,076,000	30,070,000	31,618,000	33,457,000	33,613,000	34,073,000	34,490,000	36,103,000	36,704,000	37,920,000	39,605,000	40,289,000	42,449,000	14,560,000	14,003,000	11,188,000	9,093,000	8,548,000	7,855,000	6,428,000	6,743,000	6,601,000	7,034,000	7,861,000	8,492,000	9,236,000	10,544,000	11,655,000	12,779,000	14,329,000	15,514,000	16,937,000	17,592,000	18,398,000	17,359,000	16,180,000	13,932,000	12,311,000	12,350,000
operating lease right-of-use assets	40,846,000	41,695,000	42,583,000	43,504,000	44,408,000	16,091,000	17,344,000	22,391,000	30,672,000	32,593,000	34,610,000	36,444,000	38,247,000	39,763,000	41,533,000	43,274,000	44,921,000	46,617,000	45,862,000	28,580,000	29,162,000	29,951,000	30,700,000	31,435,000	32,118,000	32,827,000	33,510,000	34,175,000	34,811,000
long-term restricted cash	1,571,000	1,532,000	1,532,000	1,532,000	1,532,000	1,532,000	1,532,000	1,922,000	2,422,000	2,422,000	2,422,000	2,422,000	2,922,000	2,922,000	2,922,000	2,922,000	4,982,000	4,592,000	4,560,000	3,000,000	3,500,000	3,500,000	3,500,000	3,500,000	4,000,000	4,000,000	4,000,000	4,000,000	4,500,000	4,500,000	4,500,000	4,500,000	4,500,000	4,500,000	4,500,000	4,500,000	4,500,000	4,500,000	4,500,000	4,500,000	4,500,000	4,500,000
intangible assets	14,104,000	15,124,000	16,143,000	17,163,000	18,182,000	389,572,000	436,426,000	443,278,000	450,131,000	456,984,000	461,838,000	409,779,000	410,011,000	410,245,000	410,294,000	410,523,000	410,751,000	410,979,000	411,206,000
goodwill	317,761,000	317,761,000	317,761,000	317,761,000	317,761,000	317,761,000	369,061,000	369,061,000	462,261,000	462,261,000	463,843,000	409,974,000	409,974,000	409,974,000	409,974,000	409,974,000	409,974,000	409,974,000	411,533,000
other long-term assets	14,190,000	8,773,000	8,776,000	9,011,000	9,189,000	9,305,000	9,503,000	9,790,000	10,119,000	13,274,000	13,004,000	13,143,000	13,319,000	10,528,000	1,176,000	1,205,000	1,340,000	1,170,000	70,000	65,000	67,000	43,000	42,000	41,000	40,000	42,000	41,000	41,000	65,000	43,000	43,000	43,000	46,000	45,000	188,000	184,000	219,000	9,813,000	9,665,000	7,628,000	7,529,000	7,518,000	5,715,000	153,000	156,000	162,000	471,000	482,000	486,000	490,000	493,000	508,000	514,000		356,000	350,000	340,000		319,000	312,000			300,000
total assets	782,365,000	784,083,000	803,158,000	825,470,000	860,789,000	1,260,447,000	1,450,052,000	1,509,491,000	1,669,920,000	1,746,013,000	1,898,354,000	1,847,631,000	1,896,417,000	1,767,086,000	1,818,949,000	1,876,142,000	1,936,666,000	2,006,970,000	2,034,155,000	1,245,781,000	1,252,888,000	413,980,000	300,318,000	213,648,000	234,764,000	147,985,000	146,110,000	170,582,000	185,577,000	170,275,000	182,906,000	137,058,000	156,949,000	144,084,000	157,904,000	177,905,000	135,508,000	137,884,000	150,635,000	161,371,000	140,175,000	131,107,000	99,777,000	96,770,000	106,421,000	124,523,000	121,642,000	128,241,000	141,040,000	136,185,000	152,800,000	134,277,000	139,774,000	129,683,000	148,208,000	169,930,000	194,738,000	218,316,000	237,961,000	261,220,000	278,558,000	305,747,000	129,936,000
liabilities and stockholders’ equity
current liabilities
accounts payable	13,609,000	20,770,000	16,362,000	15,055,000	14,037,000	16,590,000	12,064,000	17,488,000	21,006,000	15,062,000	16,106,000	16,512,000	17,390,000	12,028,000	12,853,000	12,883,000	17,607,000	11,002,000	4,960,000	4,761,000	3,471,000	3,579,000	5,406,000	7,436,000	4,223,000	8,368,000	8,111,000	8,011,000	8,740,000	6,736,000	5,966,000	4,169,000	8,567,000	9,093,000	8,574,000	6,514,000	8,221,000	8,359,000	8,311,000	5,395,000	4,734,000	4,749,000	6,097,000	5,818,000	6,924,000	5,608,000	5,845,000	5,379,000	3,926,000	1,717,000	3,413,000	2,605,000	3,011,000	2,988,000	2,897,000	4,061,000	4,250,000	4,742,000	8,158,000	9,032,000	9,432,000	9,515,000	13,211,000
accrued expenses	33,904,000	33,646,000	29,172,000	26,541,000	29,337,000	22,595,000	19,183,000	22,456,000	21,991,000	45,708,000	34,660,000	27,010,000	19,380,000	32,596,000	24,886,000	25,174,000	19,489,000	36,261,000	30,820,000	22,907,000	14,672,000	17,350,000	15,079,000	12,203,000	17,963,000	13,242,000	15,823,000	14,107,000	11,158,000	12,823,000	9,298,000	10,935,000	10,243,000	12,618,000	11,232,000	17,840,000	17,246,000	16,604,000	16,482,000	16,329,000	12,201,000	15,551,000	11,342,000	11,316,000	9,438,000	11,441,000	8,726,000	9,225,000
deferred revenue, current	16,330,000	15,936,000	16,049,000	14,863,000	15,241,000	13,864,000	17,292,000	19,212,000	17,346,000	16,342,000	22,372,000	24,983,000	30,866,000	30,498,000	30,689,000	32,084,000	12,729,000	10,977,000	9,773,000	9,534,000	9,607,000	8,722,000	6,982,000	6,932,000	7,107,000	7,610,000																									10,359,000	3,347,000	2,961,000	3,378,000	3,555,000
operating lease liabilities, current	277,000	448,000	621,000	703,000	2,417,000	10,026,000	10,675,000	12,487,000	9,772,000	9,591,000	9,460,000	9,243,000	9,018,000	8,886,000	8,612,000	8,350,000	8,056,000	7,710,000	7,128,000	4,644,000	4,448,000	4,332,000	4,217,000	4,103,000	3,967,000	3,837,000	3,724,000	3,631,000	3,521,000
other liabilities, current	1,235,000	2,031,000	1,005,000	2,592,000	5,570,000	3,224,000	783,000	6,747,000	2,836,000	8,326,000	5,170,000	7,336,000	4,670,000	7,233,000	4,609,000	5,905,000	3,129,000	5,759,000	2,927,000	3,587,000	1,539,000	4,519,000	584,000	2,188,000	714,000	225,000	1,110,000	1,764,000	312,000	788,000	645,000	744,000	145,000	605,000	1,428,000	1,915,000	167,000	1,681,000	742,000	1,422,000	1,444,000	241,000	627,000	991,000	1,410,000	1,534,000	2,477,000	1,304,000
total current liabilities	65,355,000	72,831,000	63,209,000	59,754,000	66,602,000	66,299,000	59,997,000	78,390,000	72,951,000	95,029,000	183,961,000	271,409,000	265,674,000	263,335,000	81,649,000	84,396,000	61,010,000	71,709,000	55,608,000	45,433,000	33,737,000	38,502,000	130,268,000	130,862,000	131,974,000	49,153,000	50,693,000	49,453,000	45,097,000	26,884,000	21,649,000	22,264,000	24,948,000	28,635,000	30,292,000	35,694,000	35,440,000	33,774,000	32,106,000	33,813,000	32,010,000	38,178,000	38,754,000	39,017,000	38,411,000	31,489,000	29,140,000	27,967,000	22,513,000	22,555,000	22,479,000	15,093,000	13,579,000	14,743,000	13,626,000	14,926,000	19,796,000	19,376,000	21,132,000	21,463,000	24,132,000	20,840,000	22,913,000
deferred revenue, non-current	3,554,000	3,929,000	4,400,000	5,709,000	5,855,000	5,900,000	5,455,000	5,706,000	6,127,000	5,530,000	5,053,000	4,992,000	1,849,000	1,794,000	1,762,000	1,827,000	25,246,000	25,049,000	18,447,000	10,158,000	5,687,000	1,568,000	1,761,000	1,531,000	1,484,000	1,951,000																									28,875,000	734,000	794,000	800,000	1,000,000	1,478,000	1,443,000	1,616,000
operating lease liabilities, non-current	59,004,000	56,592,000	54,300,000	52,082,000	50,480,000	14,914,000	16,933,000	19,620,000	29,049,000	31,606,000	34,100,000	36,599,000	38,969,000	41,070,000	43,163,000	45,497,000	47,740,000	49,970,000	49,954,000	35,431,000	36,485,000	37,667,000	38,793,000	39,863,000	40,903,000	41,964,000	42,968,000	43,921,000	44,861,000
convertible senior notes, net, non-current	644,107,000	645,382,000	645,159,000	646,436,000	646,214,000	647,494,000	893,144,000	892,844,000	892,545,000	892,243,000	891,996,000	891,795,000	896,839,000	896,683,000	896,529,000	896,374,000	896,220,000	896,067,000	895,915,000
other liabilities, non-current	7,979,000					546,000	751,000	751,000	751,000	751,000	1,051,000	837,000	969,000	1,300,000	1,759,000	2,946,000	3,218,000	3,471,000	4,850,000	752,000	752,000	752,000															1,741,000	1,683,000	1,605,000	1,532,000	1,462,000	1,386,000	1,323,000	2,192,000	2,192,000	2,153,000	2,505,000	2,847,000
total liabilities	779,999,000	778,734,000	767,068,000	763,981,000	769,151,000	753,853,000	996,930,000	1,016,791,000	1,020,903,000	1,044,709,000	1,134,611,000	1,205,632,000	1,204,300,000	1,204,182,000	1,192,358,000	1,194,256,000	1,202,088,000	1,215,983,000	1,193,348,000	987,536,000	972,335,000	78,489,000	170,822,000	172,256,000	174,361,000	93,068,000	95,096,000	94,828,000	90,727,000	56,214,000	51,026,000	51,584,000	54,211,000	57,981,000	56,496,000	62,045,000	66,323,000	53,216,000	51,955,000	53,302,000	51,399,000	57,567,000	58,407,000	62,934,000	65,949,000	69,574,000	68,607,000	69,226,000	65,515,000	67,005,000	69,257,000	33,879,000	32,683,000	20,301,000	19,671,000	21,726,000	26,835,000	26,853,000	27,277,000	27,894,000	29,887,000	25,881,000	28,261,000
commitments and contingencies
stockholders’ equity
preferred stock, 0.001 par value:
authorized 50,000 shares; no shares issued or outstanding
common stock
authorized 1,000,000 shares; issued and outstanding 310,487 and 301,956 shares at march 31, 2026 and december 31, 2025, respectively	311,000
additional paid-in capital	2,705,779,000	2,699,892,000	2,690,304,000	2,677,853,000	2,665,958,000	2,654,804,000	2,602,592,000	2,583,523,000	2,566,304,000	2,539,892,000	2,522,382,000	2,334,623,000	2,314,146,000	2,099,782,000	2,080,581,000	2,058,103,000	2,038,030,000	2,009,945,000	1,989,322,000	1,423,357,000	1,404,585,000	1,372,083,000	1,241,002,000	1,129,091,000	1,125,229,000	1,120,999,000	1,116,999,000	1,112,610,000	1,107,121,000										867,078,000	858,946,000	821,169,000		753,048,000	747,330,000	742,027,000		715,439,000	712,237,000	709,636,000										629,365,000	622,542,000	615,591,000	612,001,000	22,443,000
accumulated other comprehensive income	-147,000	457,000	415,000	267,000	381,000	422,000	1,553,000	-523,000	-306,000	219,000								-1,087,000	27,000	-6,000	74,000	85,000	118,000	243,000	30,000	5,000	11,000	17,000	6,000					-32,000		-16,000		5,000	23,000	52,000	41,000		6,000	12,000	16,000	9,000	23,000	42,000	18,000	14,000	11,000	-2,000	11,000	30,000	66,000	75,000	135,000	57,000		181,000	3,000	-21,000	5,000
accumulated deficit	-2,703,577,000	-2,695,302,000	-2,654,931,000	-2,616,931,000	-2,575,001,000	-2,148,926,000	-2,151,297,000	-2,090,572,000	-1,917,253,000	-1,839,075,000	-1,757,057,000	-1,690,188,000	-1,620,355,000	-1,532,340,000	-1,447,956,000	-1,370,985,000	-1,299,591,000	-1,218,092,000	-1,148,763,000	-1,165,305,000	-1,124,304,000	-1,036,869,000	-1,111,804,000	-1,088,096,000	-1,065,010,000	-1,066,240,000	-1,066,149,000	-1,037,026,000	-1,012,430,000	-982,106,000	-951,307,000	-926,263,000	-903,723,000	-879,733,000	-858,971,000	-836,950,000	-811,411,000	-787,544,000	-768,514,000	-751,020,000	-732,521,000	-713,169,000	-711,760,000	-713,581,000	-701,646,000	-681,473,000	-662,498,000	-653,335,000	-634,199,000	-615,313,000	-598,082,000	-577,595,000	-557,124,000	-536,020,000	-514,351,000	-491,622,000	-469,135,000	-441,555,000	-418,732,000	-389,451,000
total stockholders’ equity	2,366,000	5,349,000	36,090,000	61,489,000	91,638,000	506,594,000	453,122,000	492,700,000	649,017,000	701,304,000	763,743,000	641,999,000	692,117,000	562,904,000	626,591,000	681,886,000	734,578,000	790,987,000	840,807,000	258,245,000	280,553,000	335,491,000	129,496,000	41,392,000	60,403,000	54,917,000	51,014,000	75,754,000	94,850,000	114,061,000	131,880,000	85,474,000	102,738,000	86,103,000	101,408,000	115,860,000	69,185,000	84,668,000	98,680,000	108,069,000	88,776,000	73,540,000	41,370,000	33,836,000	40,472,000	54,949,000	53,035,000	59,015,000	75,525,000	69,180,000	83,543,000	100,398,000	107,091,000	109,382,000	128,537,000	148,204,000	167,903,000	191,463,000	210,684,000	233,326,000	248,671,000	279,866,000	-273,300,000
total liabilities and stockholders’ equity	782,365,000	784,083,000	803,158,000	825,470,000	860,789,000	1,260,447,000	1,450,052,000	1,509,491,000	1,669,920,000	1,746,013,000	1,898,354,000	1,847,631,000	1,896,417,000	1,767,086,000	1,818,949,000	1,876,142,000	1,936,666,000	2,006,970,000	2,034,155,000	1,245,781,000	1,252,888,000	413,980,000	300,318,000	213,648,000	234,764,000	147,985,000	146,110,000	170,582,000	185,577,000	170,275,000	182,906,000	137,058,000	156,949,000	144,084,000	157,904,000	177,905,000	135,508,000	137,884,000	150,635,000	161,371,000	140,175,000	131,107,000	99,777,000	96,770,000	106,421,000	124,523,000	121,642,000	128,241,000	141,040,000	136,185,000	152,800,000	134,277,000	139,774,000	129,683,000	148,208,000	169,930,000	194,738,000	218,316,000	237,961,000	261,220,000	278,558,000
contingent consideration liability, non-current						18,700,000	20,650,000	19,480,000	19,480,000	19,550,000	18,450,000				167,496,000	163,216,000	168,654,000	169,717,000	168,574,000
authorized 1,000,000 shares; issued and outstanding 301,956 and 294,418 shares at december 31, 2025 and december 31, 2024, respectively		302,000
authorized 1,000,000 shares; issued and outstanding 301,853 and 294,418 shares at september 30, 2025 and december 31, 2024, respectively			302,000
authorized 1,000,000 shares; issued and outstanding 300,350 and 294,418 shares at june 30, 2025 and december 31, 2024, respectively				300,000
authorized 1,000,000 shares; issued and outstanding 300,041 and 294,418 shares at march 31, 2025 and december 31, 2024, respectively					300,000
authorized 1,000,000 shares; issued and outstanding 294,418 and 267,744 shares at december 31, 2024 and december 31, 2023, respectively						294,000
authorized 1,000,000 shares; issued and outstanding 273,812 and 267,744 shares at september 30, 2024 and december 31, 2023, respectively							274,000
authorized 1,000,000 shares; issued and outstanding 272,491 and 267,744 shares at june 30, 2024 and december 31, 2023, respectively								272,000
authorized 1,000,000 shares; issued and outstanding 272,280 and 267,744 shares at march 31, 2024 and december 31, 2023, respectively									272,000
contingent consideration liability, current											96,193,000	186,325,000	184,350,000	172,094,000
authorized 1,000,000 shares; issued and outstanding 267,744 and 226,505 shares at december 31, 2023 and december 31, 2022, respectively										268,000
authorized 1,000,000 shares; issued and outstanding 258,374 and 226,505 shares at september 30, 2023 and december 31, 2022, respectively											258,000
accumulated other comprehensive loss											-1,840,000	-2,686,000	-1,924,000	-4,765,000	-6,260,000	-5,457,000	-4,085,000													-36,000	-24,000	-16,000	-38,000																										-4,000
authorized 1,000,000 shares; issued and outstanding 250,473 and 226,505 shares at june 30, 2023 and december 31, 2022, respectively												250,000
authorized 1,000,000 shares; issued and outstanding 249,803 and 226,505 shares at march 31, 2023 and december 31, 2022, respectively													250,000
authorized 1,000,000 shares; issued and outstanding 226,505 and 220,978 shares at december 31, 2022 and december 31, 2021, respectively														227,000
authorized 1,000,000 shares; issued and outstanding 225,916 and 220,978 shares at september 30, 2022 and december 31, 2021, respectively															226,000
authorized 1,000,000 shares; issued and outstanding 224,756 and 220,978 shares at june 30, 2022 and december 31, 2021, respectively																225,000
authorized 1,000,000 shares; issued and outstanding 224,329 and 220,978 shares at march 31, 2022 and december 31, 2021, respectively																	224,000
authorized 1,000,000 shares; issued and outstanding 220,978 and 192,294 shares at december 31, 2021 and december 31, 2020, respectively																		221,000
authorized 1,000,000 shares; issued and outstanding 220,547 shares and 192,294 shares at september 30, 2021 and december 31, 2020, respectively																			221,000
convertible senior notes																				895,762,000	895,674,000
authorized 1,000,000 shares; issued and outstanding 198,917 shares and 192,294 shares at june 30, 2021 and december 31, 2020, respectively																				199,000
authorized 1,000,000 shares; issued and outstanding 198,340 shares and 192,294 shares at march 31, 2021 and december 31, 2020, respectively																					198,000
notes payable, current																										15,871,000	15,546,000	15,233,000	14,938,000						2,907,000	2,643,000	3,123,000
authorized 1,000,000 shares; issued and outstanding 192,294 and 153,119 shares at december 31, 2020 and december 31, 2019, respectively																						192,000
deferred gain from reverse termination fee																							98,000,000	98,000,000	98,000,000
authorized 1,000,000 shares; issued and outstanding 179,937 shares and 153,119 shares at september 30, 2020 and december 31, 2019, respectively																							180,000
authorized 1,000,000 shares; issued and outstanding 154,318 shares and 153,119 shares at june 30, 2020 and december 31, 2019, respectively																								154,000
authorized 1,000,000 shares; issued and outstanding 153,953 shares and 153,119 shares at march 31, 2020 and december 31, 2019, respectively																									154,000
deferred rent, non-current																														13,765,000	13,949,000	14,106,000	14,285,000	14,453,000	14,504,000	14,599,000	14,148,000
notes payable, non-current																															14,384,000	14,121,000	13,872,000	13,635,000	10,456,000	10,441,000	13,302,000													13,347,000			12,851,000
financing derivative																														16,000	28,000	40,000	12,000	183,000	170,000	15,000	208,000	356,000	218,000	264,000	551,000	600,000	925,000	899,000	863,000	944,000	699,000	699,000	549,000	549,000	894,000	894,000	999,000
authorized 1,000,000 shares; issued and outstanding 153,119 and 150,244 shares at december 31, 2019 and december 31, 2018, respectively																										153,000
deferred service revenue, current																											6,379,000	6,707,000	6,428,000	6,537,000	5,740,000	6,416,000	5,993,000	6,319,000	6,151,000	6,782,000	6,683,000	7,130,000	6,436,000	6,970,000	6,371,000	6,815,000	6,303,000	6,507,000	6,254,000	6,121,000	5,307,000	5,274,000	3,904,000	4,046,000
deferred service revenue, non-current																											1,435,000	1,454,000	769,000	890,000	1,016,000	1,053,000	1,094,000	1,075,000	1,074,000	1,296,000	1,484,000	1,297,000	1,020,000	952,000	882,000	1,143,000	1,250,000	1,316,000	1,605,000	1,129,000	918,000	872,000	918,000	518,000
authorized 1,000,000 shares; issued and outstanding 153,031 and 150,244 shares at september 30, 2019 and december 31, 2018, respectively																											153,000
authorized 1,000,000 shares; issued and outstanding 152,959 and 150,244 shares at june 30, 2019 and december 31, 2018, respectively																												153,000
authorized 1,000,000 shares; issued and outstanding 152,672 and 150,244 shares at march 31, 2019 and december 31, 2018, respectively																													153,000
notes payable																														14,659,000								16,106,000	15,794,000	15,496,000	15,216,000	14,948,000	14,808,000	14,567,000	14,339,000	14,124,000	13,914,000	13,714,000	13,525,000		13,173,000	13,007,000
authorized 1,000,000 shares; issued and outstanding 150,244 and 116,277 shares at december 31, 2018 and 2017, respectively																														150,000
additional paid-in-capital																														1,096,053,000	1,083,062,000	1,011,621,000	1,006,367,000	965,752,000	960,265,000	952,710,000	880,505,000	872,114,000				786,636,000				736,339,000				684,413,000
authorized 1,000,000 shares; issued and outstanding 148,894 and 116,277 shares at september 30, 2018 and december 31, 2017, respectively																															149,000
authorized 1,000,000 shares; issued and outstanding 131,888 and 116,277 shares at june 30, 2018 and december 31, 2017, respectively																																132,000
authorized 1,000,000 shares; issued and outstanding 131,872 and 116,277 shares at march 31, 2018 and december 31, 2017, respectively																																	132,000
authorized 1,000,000 shares; issued and outstanding 116,277 and 92,677 shares at december 31, 2017 and 2016, respectively																																		116,000
authorized 1,000,000 shares; issued and outstanding 116,239 and 92,677 shares at september 30, 2017 and december 31, 2016, respectively																																			116,000
authorized 1,000,000 shares; issued and outstanding 115,562 and 92,677 shares at june 30, 2017 and december 31, 2016, respectively																																				116,000
authorized 1,000,000 shares; issued and outstanding 93,540 and 92,677 shares at march 31, 2017 and december 31, 2016, respectively																																					94,000
deferred contractual revenue, current																																							135,000	3,697,000	7,260,000	10,822,000	14,385,000	14,385,000	14,385,000	6,785,000	6,785,000	6,785,000	6,785,000	6,785,000
deferred contractual revenue, non-current																																							1,212,000	1,245,000	1,278,000	1,312,000	1,347,000	4,943,000	8,539,000	19,735,000	21,431,000	23,127,000	24,823,000	26,519,000
authorized 1,000,000 shares; issued and outstanding 92,677 and 79,983 shares at december 31, 2016 and 2015, respectively																																						93,000
liabilities and stockholders' equity
authorized 1,000,000 shares; issued and outstanding 92,605 shares at september 30, 2016 and 79,983 shares at december 31, 2015																																							93,000
authorized 1,000,000 shares; issued and outstanding 90,687 shares at june 30, 2016 and 79,983 shares at december 31, 2015																																								91,000
authorized 1,000,000 shares; issued and outstanding 86,986 shares at march 31, 2016 and 79,983 shares at december 31, 2015																																									87,000
authorized 1,000,000 shares; issued and outstanding 79,983 and 73,927 shares at december 31, 2015 and 2014, respectively																																										80,000
authorized 1,000,000 shares; issued and outstanding 75,705 shares at september 30, 2015 and 73,927 shares at december 31, 2014																																											76,000
authorized 1,000,000 shares; issued and outstanding 74,943 shares at june 30, 2015 and 73,927 shares at december 31, 2014																																												75,000
authorized 1,000,000 shares; issued and outstanding 74,542 shares at march 31, 2015 and 73,927 shares at december 31, 2014																																													75,000
authorized 1,000,000 shares; issued and outstanding 73,927 and 66,275 shares at december 31, 2014 and 2013, respectively																																														74,000
authorized 1,000,000 shares; issued and outstanding 70,976 shares at september 30, 2014 and 66,275 shares at december 31, 2013, respectively																																															71,000
authorized 1,000,000 shares; issued and outstanding 70,628 shares at june 30, 2014 and 66,275 shares at december 31, 2013, respectively																																																71,000
accrued expenses and other current liabilities																																																	7,678,000	9,797,000	8,506,000	8,950,000	7,425,000	8,204,000	7,009,000	6,539,000	11,478,000	10,258,000	8,872,000	9,925,000	10,233,000	7,994,000	8,516,000
facility financing obligation, current																																																	220,000	210,000	201,000	191,000	182,000	173,000	165,000
facility financing obligation, non-current																																																	2,345,000	2,403,000	2,458,000	2,513,000	2,565,000	2,613,000	2,659,000			2,786,000
deferred rent and other long-term liabilities																																																	842,000	1,114,000	1,378,000	1,638,000	1,895,000		2,386,000	2,617,000	2,849,000
authorized 1,000,000 shares; issued and outstanding 70,472 shares at march 31, 2014 and 66,275 shares at december 31, 2013, respectively																																																	70,000
authorized 1,000,000 shares; issued and outstanding 66,275 and 56,170 shares at december 31, 2013 and 2012, respectively																																																		66,000
convertible preferred stock, 0.001 par value:
common shares, ...																																																				677,995,000	664,204,000		642,822,000	639,751,000	636,903,000
authorized 1,000,000 shares; issued and outstanding 66,143 shares at september 30, 2013 and 56,170 shares at december 31, 2012																																																			681,614,000
convertible preferred stock, 0.001 par value: authorized 50,000 shares; no shares issued or outstanding
convertible preferred stock, 0.001 par value: authorized 50,000 shares; no shares issued or outstanding at march 31, 2013 and december 31, 2012
long-term assets																																																						354,000				317,000			356,000	322,000
liabilities, convertible preferred stock and stockholders’ equity
lease incentives and other long-term liabilities																																																						2,145,000				3,075,000	3,321,000	3,570,000	2,859,000	2,114,000	2,138,000
authorized 50,000 shares; no shares issued or outstanding at december 31, 2012 and 2011
authorized 1,000,000 shares; issued and outstanding 56,170 and 54,964 shares at december 31, 2012 and 2011, respectively																																																						645,372,000
preferred stock, 0.001 par value: authorized 50,000 shares; no shares issued or outstanding at september 30, 2012 and december 31, 2011
deferred revenue																																																								4,170,000	3,920,000	4,236,000	3,970,000	2,381,000	4,350,000	3,221,000	1,052,000
facility financing obligation																																																								156,000	148,000	140,000
facility financing obligation, less current portion																																																								2,705,000	2,747,000		2,824,000	2,861,000	2,896,000	2,927,000	2,918,000
convertible preferred stock, 0.001 par value: authorized 50,000 shares; no shares issued or outstanding at june 30, 2012 and december 31, 2011
convertible preferred stock, 0.001 par value: authorized 50,000 shares; no shares issued or outstanding at march 31, 2012 and december 31, 2011
authorized 50,000,000 shares; no shares issued or outstanding at december 31, 2011 and 2010
authorized 1,000,000,000 shares; issued and outstanding 54,963,770 and 52,855,267 shares at december 31, 2011 and 2010, respectively																																																										632,961,000
current portion of facility financing obligation																																																											132,000	125,000	117,000	110,000	134,000
common stock, 0.001 par value...																																																											55,000	54,000
authorized 1,000,000,000 shares; issued and outstanding 52,924,907 shares at march 31, 2011 and 52,855,267 shares at december 31, 2010																																																													53,000
deficit accumulated during the development stage																																																													-366,976,000	-332,167,000	-295,748,000
convertible preferred stock warrant liability																																																															292,000
convertible preferred stock, 0.001 and 0.0001 par value at december 31, 2010 and 2009, respectively:
authorized 50,000,000 and 116,056,382 shares at december 31, 2010 and 2009, respectively; issued and outstanding no shares at december 31, 2010 and 60,101,338 shares at december 31, 2009
stockholders’ equity (deficit) common stock, 0.001 par value:
authorized 1,000,000,000 shares; issued and outstanding 52,855,267 shares at december 31, 2010 and 656,084 shares at december 31, 2009																																																														53,000
total liabilities, convertible preferred stock and stockholders’ equity																																																														305,747,000	129,936,000
convertible preferred stock
authorized 153,394,052 shares; issued and outstanding 60,101,338 shares at december 31, 2009 and 74,367,120 shares at september 30, 2010																																																															374,975,000
authorized 121,668,835 shares; issued and outstanding 656,084 shares at december 31, 2009 and 1,249,921 shares at september 30, 2010

Cashflow Statements:

Quarterly

Annual

Unit: USD	2026-03-31	2025-12-31	2025-09-30	2025-06-30	2025-03-31	2024-12-31	2024-09-30	2024-06-30	2024-03-31	2023-12-31	2023-09-30	2023-06-30	2023-03-31	2022-12-31	2022-09-30	2022-06-30	2022-03-31	2021-12-31	2021-09-30	2021-06-30	2021-03-31	2020-12-31	2020-09-30	2020-06-30	2020-03-31	2019-12-31	2019-09-30	2019-06-30	2019-03-31	2018-12-31	2018-06-30	2018-03-31	2017-09-30	2017-06-30	2017-03-31	2016-09-30	2016-06-30	2016-03-31	2015-09-30	2015-06-30	2015-03-31	2014-09-30	2014-06-30	2014-03-31	2013-09-30	2013-06-30	2013-03-31	2012-09-30	2012-06-30	2012-03-31	2011-09-30	2011-06-30	2011-03-31	2010-09-30

cash flows from operating activities
net loss	-8,275,000	-40,371,000	-38,000,000	-41,930,000	-426,075,000	2,371,000	-60,725,000	-173,319,000	-78,178,000	-82,018,000			-88,015,000		-76,971,000	-71,394,000	-81,499,000		16,542,000				-23,708,000			-91,000	-29,123,000	-24,596,000	-30,324,000	-30,799,000	-46,719,000	-24,179,000	-71,427,000	-49,406,000	-23,867,000	-55,345,000	-37,851,000	-19,352,000	-30,287,000	-32,108,000	-20,173,000	-47,185,000	-38,022,000	-18,886,000	-62,062,000	-41,575,000	-21,104,000	-72,796,000	-50,067,000	-27,580,000	-86,565,000	-57,284,000	-34,809,000	-103,747
adjustments to reconcile net loss to net cash from operating activities
depreciation	2,200,000	2,736,000	2,461,000	2,659,000	5,131,000	2,842,000	4,193,000	3,499,000	3,240,000	2,976,000	2,903,000	2,829,000	2,755,000	2,543,000	2,346,000	2,323,000	2,268,000	2,256,000	1,745,000	1,592,000	1,606,000	1,601,000	1,581,000	1,589,000	1,657,000	1,782,000	1,897,000	1,790,000	1,796,000		3,611,000	1,802,000	6,632,000	4,839,000	2,850,000	2,822,000	1,823,000	848,000	2,694,000	1,846,000	908,000	3,311,000	2,311,000	1,221,000	4,238,000	2,897,000	1,493,000	5,041,000	3,353,000	1,629,000	4,296,000	2,855,000	1,468,000	3,703
amortization of intangible assets	1,020,000	1,019,000	1,020,000	1,019,000	366,390,000				6,853,000	6,853,000	942,000	232,000	234,000		229,000	228,000	228,000
amortization of right-of-use assets	849,000	894,000	921,000	904,000	1,258,000	1,253,000	5,054,000	3,937,000	1,921,000	1,870,000	1,610,000	1,803,000	1,527,000	1,773,000	1,740,000	1,716,000	1,696,000
share-based compensation expense	4,459,000	9,588,000	10,984,000	11,895,000	9,201,000	16,033,000	18,259,000	17,219,000	19,525,000		19,691,000	17,891,000	17,952,000
impairment charges		0	0	0	15,000,000
gain on disposal of assets	-48,100,000
accretion of discount and amortization of premium on marketable securities	-295,000	-460,000	-923,000	-1,276,000	-1,706,000	-2,381,000	-3,091,000	-3,541,000	-4,031,000		-3,975,000	-3,958,000	-2,155,000
change in the estimated fair value of contingent consideration		0	0	0	-18,700,000	-1,950,000	1,170,000	0	-70,000	1,100,000	-271,000	1,975,000	12,256,000	4,598,000	4,280,000	-5,438,000	-1,063,000
inventory provision	54,000	-200,000	1,226,000	883,000	7,659,000	903,000	-207,000	3,919,000	3,000	5,893,000	396,000	774,000	3,521,000
deferred income taxes		0	0	0	-546,000					-718,000								1,175,000
other	225,000	232,000	397,000	340,000	719,000	-1,630,000	300,000	299,000	403,000	392,000								1,000																								242,000	156,000									201,000
changes in assets and liabilities
accounts receivable	6,098,000	-4,832,000	1,641,000	-612,000	-4,121,000	1,859,000	3,050,000	-2,110,000	6,292,000	-6,129,000	-6,452,000	5,555,000	-10,803,000	3,970,000	4,302,000	794,000	-3,611,000	-295,000	-3,772,000	-7,030,000	3,931,000	-5,031,000	-460,000	-4,021,000	7,909,000	-5,300,000	2,157,000	-4,844,000	1,316,000	-2,191,000	5,987,000	4,981,000	2,524,000	1,896,000	980,000	-6,516,000	-5,182,000	-2,865,000	-758,000	-544,000	-1,881,000	376,000	-1,509,000	-637,000	-992,000	-1,282,000	813,000	4,025,000	1,186,000	3,052,000	-4,093,000	-5,096,000	282,000	-1,052
inventory	-3,206,000	3,507,000	-1,058,000	-1,330,000	-2,538,000	7,074,000	1,373,000	-5,112,000	-11,655,000	9,008,000	-3,146,000	-6,384,000	-13,319,000	-13,206,000	-7,534,000	-6,891,000	-6,275,000	-6,978,000	-423,000	-2,474,000	-2,556,000	1,892,000	834,000	-448,000	-3,374,000	1,660,000	2,295,000	1,848,000	-1,888,000	609,000	-560,000	-2,720,000	-4,027,000	-2,240,000	-149,000	-7,079,000	-4,491,000	-2,119,000	-1,990,000	-643,000	-2,122,000	-1,348,000	610,000	1,749,000	171,000	-293,000	-607,000	4,151,000	4,082,000	3,094,000	-15,071,000	-13,824,000	-6,675,000
prepaid expenses and other assets	-2,288,000	717,000	988,000	3,383,000	3,426,000	-1,306,000	-25,000	508,000	3,051,000	-1,697,000	-1,202,000	803,000	-6,888,000	-6,639,000	-5,345,000	845,000	-1,185,000	-1,023,000	306,000	368,000	-675,000	-1,279,000	-308,000	582,000	-58,000	-761,000	-150,000	301,000	87,000	-827,000	337,000	312,000	7,361,000	6,368,000	3,377,000	3,024,000	1,004,000	4,709,000	-15,410,000	83,000	43,000	85,000	7,000	-487,000	791,000	1,229,000	431,000	734,000	800,000	245,000	1,764,000	-107,000
accounts payable	-4,322,000	1,721,000	1,266,000	1,020,000	-1,525,000	3,627,000	-5,612,000	-3,254,000	6,644,000	-1,500,000	-2,556,000	-806,000	5,068,000	-486,000	180,000	-5,042,000	6,373,000	6,167,000	-1,207,000	1,250,000	153,000	-2,117,000	-1,916,000	3,090,000	-4,129,000	259,000	769,000	-1,390,000	2,075,000	687,000	-4,765,000	-942,000	432,000	-1,944,000	-89,000	2,402,000	683,000	-39,000	364,000	203,000	983,000	4,128,000	3,662,000	2,209,000	425,000	-384,000	22,000	-1,845,000	-681,000	-492,000	-1,209,000	-483,000	-183,000	7,433
accrued expenses	314,000	4,554,000	1,011,000	-2,718,000	311,000	323,000	-3,415,000	503,000	-23,753,000	11,048,000	8,011,000	7,230,000	-13,186,000	7,403,000	303,000	5,877,000	-17,234,000	5,053,000	4,707,000	8,240,000	-2,680,000	2,456,000	2,685,000	-5,760,000	4,721,000	-2,581,000	1,716,000	2,987,000	-1,703,000	3,702,000	-1,683,000	-2,402,000	-6,001,000	-2,266,000	-4,763,000	931,000	778,000	-3,350,000	1,523,000	-125,000	-2,003,000	821,000	459,000
deferred revenue	19,000	-584,000	-123,000	-524,000	1,332,000	-2,983,000	-2,171,000	1,445,000	1,601,000	-5,553,000	-2,550,000	-2,740,000	423,000	-159,000	-1,460,000	-4,064,000	1,949,000	7,806,000	8,528,000	4,398,000	5,004,000	1,547,000	280,000	-128,000	-970,000																				35,056,000	-97,000	-423,000	-1,297,000	-204,000	-489,000	749,000	-840,000	1,129,000
operating lease liabilities	1,425,000	1,384,000	1,069,000	-112,000	-1,618,000	-2,668,000	-4,504,000	-2,372,000	-2,376,000	-2,363,000	-2,282,000	-2,145,000	-1,969,000	-1,819,000	-2,072,000	-1,949,000	-1,884,000	-1,759,000	-1,087,000	-1,078,000	-1,066,000	-1,011,000	-956,000	-904,000	-931,000	-891,000
other liabilities	5,132,000	1,026,000	-1,587,000	-2,978,000	2,346,000	2,441,000	-5,964,000	4,063,000	-5,152,000	3,596,000	-1,686,000	2,994,000	-2,455,000	2,587,000	-2,079,000	2,891,000	-2,512,000	2,193,000	-2,064,000	2,048,000	-2,980,000	4,686,000	-1,603,000	1,474,000	489,000	-885,000	1,023,000	622,000	-1,323,000	-41,000	-208,000	-628,000	1,821,000	2,404,000	92,000	720,000	1,327,000	1,279,000	-316,000	-504,000	-85,000	-637,000	-607,000
net cash from operating activities	-44,691,000	-19,069,000	-18,707,000	-29,377,000	-44,056,000	-30,650,000	-45,463,000	-54,263,000	-75,682,000	-57,560,000	-65,181,000	-41,741,000	-94,691,000	-60,566,000	-63,053,000	-60,563,000	-79,029,000	-31,708,000	-40,656,000	-15,712,000	-23,104,000	-14,263,000	-17,808,000	-23,789,000	75,363,000	-18,180,000	-17,260,000	-17,559,000	-25,313,000	-18,985,000	-33,270,000	-18,773,000	-47,318,000	-29,480,000	-16,671,000	-55,028,000	-39,152,000	-20,267,000	-47,175,000	-31,405,000	-23,911,000	-36,111,000	-29,876,000	-16,256,000	-15,259,000	-33,982,000	-17,575,000	-58,599,000	-40,950,000	-17,338,000	-88,202,000	-64,351,000	-33,458,000	-82,949
capital expenditures	-3,043,000	0	86,000	-550,000	-1,389,000	-1,617,000	787,000	-1,479,000	-3,879,000	-2,024,000	-830,000	-2,268,000	-3,721,000	-4,904,000	-4,189,000	-4,019,000	-3,638,000	-2,842,000	-1,119,000	-1,569,000	-401,000	-67,000	-536,000	-319,000	-117,000	-141,000	-829,000	-613,000	-1,253,000	-58,000	-1,700,000	-344,000	-9,373,000	-6,116,000	-2,668,000	-4,396,000	-3,255,000	-457,000	-2,131,000	-1,672,000	-717,000	-1,132,000	-942,000	-477,000	-807,000	-577,000	-297,000	-1,263,000	-781,000					-2,120
free cash flows	-47,734,000	-19,069,000	-18,621,000	-29,927,000	-45,445,000	-32,267,000	-44,676,000	-55,742,000	-79,561,000	-59,584,000	-66,011,000	-44,009,000	-98,412,000	-65,470,000	-67,242,000	-64,582,000	-82,667,000	-34,550,000	-41,775,000	-17,281,000	-23,505,000	-14,330,000	-18,344,000	-24,108,000	75,246,000	-18,321,000	-18,089,000	-18,172,000	-26,566,000	-19,043,000	-34,970,000	-19,117,000	-56,691,000	-35,596,000	-19,339,000	-59,424,000	-42,407,000	-20,724,000	-49,306,000	-33,077,000	-24,628,000	-37,243,000	-30,818,000	-16,733,000	-16,066,000	-34,559,000	-17,872,000	-59,862,000	-41,731,000					-85,069
cash flows from investing activities
proceeds from disposal of assets	50,000,000
payment for waiver of milestone obligation	-1,900,000
purchases of property and equipment	-3,043,000		86,000	-550,000	-1,389,000																																									-577,000
purchases of intangible assets	-5,000,000		0	0	-5,000,000
purchases of investments	-52,448,000		-65,825,000	-56,172,000	-61,820,000		-114,600,000	-111,657,000	-191,907,000		-76,869,000																																			-111,524,000
maturities of investments	48,250,000	59,984,000	84,641,000	82,005,000	113,443,000	113,531,000	128,817,000	189,973,000	161,650,000	138,268,000	320,124,000	147,265,000	163,864,000	220,375,000	124,910,000	108,455,000	122,060,000	199,220,000	73,110,000	81,775,000	68,400,000	38,900,000	52,250,000	43,700,000	18,750,000	11,750,000	24,950,000	27,550,000	56,860,000	12,500,000	48,200,000	21,700,000	68,071,000	46,511,000	34,905,000	46,208,000	22,082,000	15,539,000	68,553,000	51,898,000	34,464,000	119,673,000	76,195,000	45,190,000	133,391,000	99,373,000	37,180,000	92,392,000	63,972,000	29,889,000	194,929,000	125,285,000
net cash from investing activities	35,859,000	26,029,000	18,902,000	25,283,000	45,234,000	58,238,000	23,065,000	76,837,000	-34,136,000		242,323,000	-98,591,000	-72,553,000		53,908,000	-60,281,000	42,053,000		-291,646,000	-460,808,000	8,170,000		-63,641,000	-2,859,000	-54,327,000		19,659,000			-5,513,000	4,442,000	-7,749,000	-12,229,000	-17,112,000	25,480,000	-21,536,000	-32,401,000	-23,241,000	31,036,000	16,469,000	15,299,000	21,073,000	8,377,000	8,198,000	-8,965,000	-12,728,000	-5,583,000	29,589,000	13,688,000	12,978,000	-9,354,000	-32,436,000	-29,910,000	-50,738
cash flows from financing activities
proceeds from issuance of common stock from equity plans	1,437,000	0	1,469,000	0	1,959,000	0	812,000	0	6,891,000	936,000	4,562,000	2,586,000	7,235,000	1,247,000	3,543,000	848,000	5,592,000	1,685,000	4,810,000	2,968,000	22,343,000	32,186,000	13,347,000	628,000	199,000	131,000	327,000	1,400,000	6,690,000	5,471,000	2,517,000	2,487,000	8,818,000	6,231,000	3,408,000	7,529,000	4,502,000	3,423,000	5,465,000	2,984,000	2,434,000	3,319,000	2,691,000	2,311,000
net cash from financing activities	1,437,000	0	1,469,000	0	1,959,000	-50,200,000	812,000	-152,000	6,553,000	-81,602,000	-781,000	-4,715,000	195,989,000	819,000	3,133,000	455,000	5,215,000	1,324,000	299,656,000	2,880,000	865,721,000	125,877,000	107,135,000	628,000	18,199,000	18,131,000	327,000	1,400,000	6,690,000	5,279,000	35,379,000	35,473,000	68,713,000	66,305,000	3,408,000	65,729,000	62,702,000	29,959,000	6,898,000	4,417,000	2,434,000	24,087,000	23,337,000	22,957,000	42,451,000	41,003,000	29,656,000	2,703,000	2,020,000	1,755,000	7,486,000	3,651,000	333,000	107,172
net increase in cash, cash equivalents, and restricted cash	-7,395,000	6,960,000			3,137,000				-103,265,000	-205,737,000			28,745,000	20,656,000
cash, cash equivalents, and restricted cash at beginning of period	65,259,000	0	0	0	57,592,000	0	0	0	182,633,000	0	0	0	328,311,000	0
cash, cash equivalents, and restricted cash at end of period	57,864,000	6,960,000	1,664,000	-4,094,000	60,729,000	-22,612,000	-21,586,000	22,422,000	79,368,000	-205,737,000	176,361,000	-145,047,000	357,056,000	20,656,000
cash and cash equivalents at end of period	56,274,000	7,240,000	1,664,000	-3,704,000	58,507,000	-22,612,000	-21,544,000	22,880,000	76,646,000	-205,737,000	176,361,000	-144,547,000	353,834,000	20,656,000	-6,012,000	-118,129,000	428,574,000	35,337,000	-34,406,000	-472,604,000	932,398,000	12,583,000	25,686,000	-25,520,000	68,862,000	-3,457,000	2,726,000	-7,847,000	38,205,000	-19,219,000	23,058,000	25,458,000	25,931,000	36,478,000	28,982,000	22,794,000	24,778,000	20,080,000	27,208,000	25,930,000	30,271,000	35,411,000	28,200,000	41,261,000	64,767,000	40,833,000	53,038,000	32,558,000	33,623,000	56,260,000	57,580,000	54,514,000	84,615,000	62,717
restricted cash at end of period	1,590,000	-280,000	0	-390,000	2,222,000	0	-42,000	-458,000	2,722,000	0	0	-500,000	3,222,000	0	0	-2,260,000	5,482,000	32,000	1,760,000	-1,036,000	4,336,000	836,000	0	-500,000	4,000,000	0	0	-500,000	4,500,000	0	4,500,000	4,500,000
supplemental disclosure of non-cash investing and financing activities
right-of-use asset and lease liability recognized due to lease extension			0	0	29,575,000
merger-related compensation expense										0
loss on extinguishment of debt										0	0
gain on debt restructuring
contingent consideration liability										-14,150,000
purchase of property and equipment						-1,617,000	787,000	-1,479,000	-3,879,000	-2,024,000	-830,000	-2,268,000	-3,721,000	-4,904,000	-4,189,000	-4,019,000	-3,638,000	-2,842,000	-1,119,000	-1,569,000	-401,000	-67,000	-536,000	-319,000	-117,000	-141,000	-829,000	-613,000	-1,253,000	-58,000	-1,700,000	-344,000	-9,373,000	-6,116,000	-2,668,000	-5,556,000	-3,255,000	-457,000	-2,131,000	-1,672,000	-717,000	-1,132,000	-942,000	-477,000	-807,000		-297,000	-1,263,000	-781,000	-274,000	-7,846,000	-5,588,000	-1,496,000	-4,030
purchase of intangible assets
cash paid for purchases of acquired entities, net of cash acquired
purchase of investments													-233,291,000	-134,889,000	-66,813,000	-164,717,000	-76,369,000	-130,625,000	-222,021,000	-570,974,000	-64,426,000	-138,728,000	-115,355,000	-46,240,000	-72,960,000	-15,017,000	-5,962,000	-19,125,000	-17,623,000	-17,955,000	-44,500,000	-31,547,000	-74,591,000	-61,181,000	-10,419,000	-82,028,000	-64,572,000	-43,383,000	-43,715,000	-40,580,000	-25,265,000	-97,468,000	-66,876,000	-36,515,000	-141,549,000		-42,466,000	-69,436,000	-54,359,000	-20,137,000	-232,957,000	-188,653,000	-131,221,000	-76,315
sales of investments						26,795,000				0	0	0	595,000					0	178,177,000	29,960,000	4,597,000					0				0	2,442,000	2,442,000	3,662,000	3,662,000	3,662,000	19,830,000	13,334,000	4,949,000	8,317,000	6,817,000	6,817,000							7,896,000	4,856,000	3,500,000	36,520,000	36,520,000
proceeds from issuance of common stock under equity offerings, net of issuance costs										0	0	0	189,200,000					-1,000
payment of debt issuance costs										-50,000	-489,000
payment of contingent consideration										-82,043,000
pacific biosciences of california, inc.consolidated statements of cash flows
payments made in conjunction with convertible notes exchange
notes payable principal payoff						0	0	-152,000	-338,000	-445,000	-486,000	-465,000	-446,000	-428,000	-410,000	-393,000	-377,000					0	0	0	-16,000,000								-4,500,000
supplemental disclosure of cash flow information
interest paid
inventory transferred to property and equipment																						556,000	175,000			278,000	357,000			1,207,000	492,000		1,460,000	608,000			1,245,000	912,000
property and equipment transferred to inventory
right-of-use asset and liability additions and modifications
issuance of common stock in conjunction with convertible notes exchange
issuance of common stock in acquisition of apton and omniome
issuance of common stock in connection with apton liquidity event bonus plan
convertible notes exchange
issuance of common stock following milestone achievement
net decrease in cash, cash equivalents, and restricted cash
amortization of acquired intangible assets							6,852,000
goodwill impairment							0
cash paid for purchase of apton, net of cash acquired
loss from continuation advances																		0	0	0	52,000,000
share-based compensation
amortization of premium and accretion of discount on marketable securities														-1,313,000
net cash from in investing activities
continuation advances																		0	0	0	-52,000,000		0
proceeds from issuance of convertible senior notes, net of issuance costs																		0	0	-88,000	895,624,000
convertible senior notes exchange
net income																					-87,435,000				1,262,000
adjustments to reconcile net income to net cash from operating activities
amortization of debt discount and financing costs												162,000	162,000	160,000	161,000	160,000	159,000	158,000	155,000	152,000	74,000	0	0	0	129,000	325,000	313,000	295,000	279,000	275,000	486,000	237,000	931,000	652,000	319,000	846,000	548,000	268,000	699,000	453,000	220,000	579,000	375,000	182,000	418,000	248,000
loss on disposition of equipment												-156,000	201,000	196,000	5,000	-23,000	100,000									50,000
amortization of intangibles
cash paid for purchase of circulomics, net of cash acquired																		0
cash paid for purchase of omniome, net of cash acquired																		0
issuance of common stock in acquisition of omniome																		1,000
stock-based compensation															18,936,000	19,019,000	22,703,000	18,938,000	28,447,000	15,805,000	10,165,000	5,275,000	4,992,000	3,234,000	4,032,000	3,869,000	4,062,000	4,089,000	4,381,000	7,522,000	10,506,000	5,282,000	14,962,000	9,994,000	4,984,000	14,726,000	9,619,000	4,581,000	9,813,000	6,575,000	3,255,000	6,944,000	4,492,000	2,270,000	7,361,000	5,190,000	2,746,000	7,158,000	4,770,000	2,187,000	9,100,000	6,111,000	3,104,000	6,268
amortization from investment premium																385,000	758,000	904,000	1,325,000	1,217,000	565,000		36,000	-94,000	-83,000				-416,000
net increase in cash and cash equivalents and restricted cash																-120,389,000	-31,761,000	35,369,000	-32,646,000	-473,640,000	850,787,000	13,119,000	25,686,000	-26,020,000	39,235,000	-3,457,000	2,726,000	-8,347,000	19,361,000		6,551,000	8,951,000
cash and cash equivalents and restricted cash at beginning of period																0	465,817,000	0	0	0	85,947,000	300,000	0	0	33,627,000	0	0	0	23,344,000	0	21,007,000	21,007,000
cash and cash equivalents and restricted cash at end of period																-120,389,000	434,056,000	35,369,000	-32,646,000	-473,640,000	936,734,000	13,419,000	25,686,000	-26,020,000	72,862,000	-3,457,000	2,726,000	-8,347,000	42,705,000	-19,219,000	27,558,000	29,958,000
loss from derivative																																	640,000	485,000
amortization of operating lease right-of-use assets																			812,000	801,000	790,000		735,000	683,000	709,000		665,000	636,000	653,000
deferred gain from reverse termination fee																							0	0	98,000,000
issuance costs paid for underwritten public equity offering																				0	-246,000
gain from continuation advances from illumina
amortization and accretion for investment premium
continuation advances from illumina
proceeds from issuance of common stock from underwritten public equity offerings, net of issuance costs
gain from continuation advances																							0	0	-34,000,000
gain on derivative																												0	-16,000			-171,000
proceeds from issuance of common stock from underwritten public equity offering, net of issuance costs																															32,862,000	32,986,000	52,530,000
supplemental disclosure of non-cash operating activities
inventory transferred from property and equipment																											2,194,000
proceeds from continuation advances																									34,000,000
loss on return of building under capital lease
proceeds from disposal of property and equipment
proceeds from issuance of common stock from "at-the-market" offerings, net of issuance costs
loss on derivative																															-143,000
accretion from investment discount																											-144,000
deferred service revenue																											-347,000	964,000	-230,000	671,000	75,000	-307,000	-1,202,000	-349,000	-260,000	-502,000	-36,000	-705,000	303,000	573,000	609,000	1,661,000	1,582,000	258,000
net cash provided by (used in) investing activities																													37,984,000
depreciation and amortization
non-cash portion of gain on lease amendments																																							-3,043,000
deferred contractual revenue																																				-10,787,000	-7,192,000	-3,596,000	-10,788,000	-7,192,000	-3,596,000	-5,088,000	-3,392,000	-1,696,000
net decrease in cash and cash equivalents and restricted cash
property and equipment paid by landlord																																	12,600,000	12,600,000	12,600,000
changes in deposits for property and equipment paid in prior period																																	9,694,000	9,694,000	9,694,000
property and equipment returned to landlord																																	1,854,000	1,854,000
other items																															-194,000	-38,000	36,000	87,000	-145,000	-270,000	-182,000	74,000	21,000	-22,000	-69,000				-73,000	-73,000	121,000	270,000	53,000	53,000	42,000		26,000
disposal of property and equipment																																	2,000	12,000		10,000	10,000	111,000	12,000	6,000
notes payable principal payment
proceeds from issuance of common stock from at-the-market equity offering, net of issuance costs																																	11,865,000	11,865,000		58,200,000	58,200,000	26,536,000	1,433,000	1,433,000		20,768,000	20,646,000	20,646,000
changes in unpaid property and equipment																															159,000	319,000	846,000	3,323,000	5,356,000
notes payable principal paying off																																		-4,500,000
impact from adoption of asc 606 revenue from contracts with customers																																189,000
inventory transferred to (from) property and equipment																																-343,000															-398,000
long-term restricted cash
proceeds from issuance of common stock from "at-the-market" offering, net of issuance costs
net decrease in cash and cash equivalents																																				-10,835,000	-8,851,000	-13,549,000								-5,707,000		-26,307,000	-25,242,000	-2,605,000	-90,070,000
cash and cash equivalents at beginning of period																																	16,765,000	16,765,000	16,765,000	33,629,000	33,629,000	33,629,000	36,449,000	36,449,000	36,449,000	26,362,000	26,362,000	26,362,000	46,540,000	46,540,000	46,540,000	58,865,000	58,865,000	58,865,000	147,650,000	147,650,000	147,650,000	89,232
net increase in cash and cash equivalents																																	9,166,000	19,713,000	12,217,000				-9,241,000	-10,519,000	-6,178,000	9,049,000	1,838,000	14,899,000	18,227,000		6,498,000					-93,136,000	-63,035,000	-26,515
proceeds from issuance of common stock from underwritten public equity offering, net of issue costs																																		52,709,000
purchase of property and equipment through accounts payable																																				1,160,000
instruments that were transferred from inventory to property and equipment																																				1,561,000
proceeds from issuance of debt agreement, net of issuance costs
leased instruments that were transferred from inventory to property and equipment																																							1,704,000
inventory transferred to (from) property and equipment for internal use
proceeds from issuance of facility agreement, net of issuance costs
accrued expenses and other current liabilities																																												-2,119,000	302,000	746,000	-779,000	-3,249,000	-3,719,000	1,220,000	1,658,000	2,711,000	897,000	7,061
deferred rent and other long-term liabilities																																												-320,000				-791,000	-523,000	-257,000
other long-term liabilities																																													-894,000
proceeds from issuance of common stock, net of issuance costs																																													22,685,000	21,237,000	9,890,000
proceeds from issuance of debt facility, net of issuance costs																																													19,766,000	19,766,000	19,766,000
lease incentives and other long-term liabilities																																														-588,000	-288,000				1,127,000	1,405,000	721,000	-300
proceeds from issuance of convertible preferred stock																																																						105,874
proceeds from issuance of common stock																																																2,703,000	2,020,000	1,755,000	7,486,000
assets acquired under facility lease																																																						2,971
additions to property and equipment under tenant improvement allowances																																																						1,910
inventory transferred to property and equipment for internal use																																																1,164,000	1,164,000	602,000	1,673,000	1,136,000
conversion of convertible preferred stock to common stock upon ipo
reclassification of preferred warrants to common stock warrants
issuance of common stock related to convertible preferred stock offering
vesting of stock options related to early exercises																																																			780,000	780,000	153,000
purchases of property and equipment through accrued liabilities																																																					1,495,000
proceeds from exercise of junior preferred stock options
proceeds from issuance of common stock in ipo, net of issuance costs
repurchases of common stock
payment of notes payable
assets acquired under facility financing obligation
prepaid expenses and other current assets																																																					616,000	-2,292
other long-term assets																																																					-34,000	-89
sales and maturities of investments																																																					102,807,000	29,607
proceeds from exercise of common stock options																																																				3,651,000	333,000	1,298
repurchases of junior preferred stock
issuance of convertible preferred stock warrants
reclassification of convertible preferred stock warrants to liabilities
amortization of deferred financing costs
change in convertible preferred stock warrant liability fair value																																																						66
proceeds from issuance of notes payable

Pacific Biosciences of California, Inc(NASDAQ:PACB)

Pacific Biosciences of California, Inc
(NASDAQ:PACB)