7Baggers

Novavax, Inc
(NASDAQ:NVAX) 

NVAX stock logo

Novavax, Inc., a biotechnology company, focuses on the discovery, development, and commercialization of vaccines to prevent serious infectious diseases and address health needs. The company's vaccine candidates include NVX-CoV2373, a coronavirus vaccine candidate that is in two Phase III trials, one...

Founded: 1987
Full Time Employees: 522
CEO: Stanley C. Erck  
Sector: Healthcare
Industry: Biotechnology

Share this website to your friends
• Market Cap:
• Exchange:
• Shs Outstanding:
• Employees:
• Beta:
• Return on Equity (ROE) ttm:
• Return on Assets (ROA) ttm:
• EPS ttm:
• Book value per Share:
• Cash per Share:
• Current ast per Share:
• P/E ttm:
• P/E forward:
• P/E ttm high:
• P/E ttm low:
• P/S ttm:
• P/B ttm:
• P/FCF ttm:
• PEG ratio:
• Cash Ratio ttm:
• Quick Ratio ttm:
• Current Ratio ttm:
• Gross Mgn ttm:
• EBITDA Mgn ttm:
• Operating Mgn ttm:
• Net Income Mgn ttm:
• Trailing Div yield:
• Forward Div yield:
• Payout Ratio ttm:
• Ex-Dividend date:
• Target Price High:
• Target Price Low:
• Target Price Mean:
• Number of Analysts:
• Debt Ratio ttm:
• Debt to Equity ttm:
• Total Net Debt:
At a glance:
Bull Thesis:
Bear Thesis:
Main Competitors:
Moat:
Income Statements:
Quarterly
Annual
    Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-09-30 2012-06-30 2012-03-31 2011-09-30 2011-06-30 2011-03-31 2010-09-30 2010-06-30 2010-03-31 2009-09-30 2009-06-30 2009-03-31 2008-12-31 2008-09-30 2008-06-30 2008-03-31 2007-12-31 2007-09-30 2007-06-30 2007-03-31 2006-12-31 2006-09-30 2006-06-30 2006-03-31 2005-12-31 2005-09-30 2005-06-30 2005-03-31 2004-12-31 2004-09-30 2004-06-30 2004-03-31 2003-12-31 2003-09-30 2003-06-30 2003-03-31 2002-12-31 2002-09-30 2002-06-30 2002-03-31 
                                                                                                
      revenue:
                                                                                                
      product sales
    42,200,000 39,197,000 13,442,000 10,724,000 621,678,000 49,774,000 38,210,000 19,904,000 82,324,000 251,452,000 2,231,000 285,163,000 -7,457,000 287,787,000 626,091,000 55,455,000 585,628,000                                                                    1,627,000 3,647,000 1,959,000     4,776,000 
      licensing, royalties, and other
    97,314,000 107,942,000 57,003,000 228,516,000 44,977,000 38,537,000 46,302,000 395,580,000                                                                                     
      total revenue
    139,514,000 147,139,000 70,445,000 239,240,000 666,655,000 88,311,000 84,512,000 415,484,000 93,855,000 291,342,000 186,986,000 424,426,000 80,951,000 357,399,000 734,577,000 185,925,000 703,971,000 222,200,000 178,844,000 298,017,000 447,229,000 279,659,000 2,507,000 35,538,000 3,377,000 8,816,000 2,507,000 3,357,000 3,982,000 6,127,000 7,735,000 10,773,000 9,653,000 10,412,000 8,352,000 6,732,000 5,680,000 5,399,000 3,231,000 2,505,000 4,218,000 5,853,000 6,525,000 13,996,000 9,877,000 8,214,000 8,259,000 7,462,000 8,748,000 4,802,000 3,531,000 3,833,000 5,765,000                                        
      yoy
    -79.07% 66.61% -16.64% -42.42% 610.30% -69.69% -54.80% -2.11% 15.94% -18.48% -74.55% 128.28% -88.50% 60.85% 310.74% -37.61% 57.41% -20.55% 7033.79% 738.59% 13143.38% 3072.18% 0.00% 958.62% -15.19% 43.89% -67.59% -68.84% -58.75% -41.15% -7.39% 60.03% 69.95% 92.85% 158.50% 168.74% 34.66% -7.76% -50.48% -82.10% -57.29% -28.74% -21.00% 87.56% 12.91% 71.05% 133.90% 94.68% 51.74%                                            
      qoq
    -5.18% 108.87% -70.55% -64.11% 654.89% 4.50% -79.66% 342.69% -67.79% 55.81% -55.94% 424.30% -77.35% -51.35% 295.09% -73.59% 216.82% 24.24% -39.99% -33.36% 59.92% 11055.13% -92.95% 952.35% -61.69% 251.66% -25.32% -15.70% -35.01% -20.79% -28.20% 11.60% -7.29% 24.66% 24.06% 18.52% 5.20% 67.10% 28.98% -40.61% -27.93% -10.30% -53.38% 41.70% 20.25% -0.54% 10.68% -14.70% 82.17% 36.00% -7.88% -33.51%                                         
      expenses:
                                                                                                
      cost of sales
    30,695,000 22,104,000 21,496,000 15,325,000 14,115,000 36,669,000 60,619,000 46,242,000 59,209,000 154,976,000 98,929,000 55,777,000 34,086,000 181,765,000 434,593,000 271,077,000 15,204,000                                                                    346,000 761,000 388,000      
      research and development
    95,472,000 75,876,000 98,274,000 79,233,000 88,937,000 104,380,000 87,164,000 106,946,000 92,679,000 164,697,000 106,229,000 219,475,000 247,101,000 257,850,000 304,297,000 289,648,000 383,483,000 962,957,000 408,195,000 570,685,000 592,671,000 401,199,000 18,611,000 34,846,000 16,895,000 29,340,000 18,611,000 30,417,000 35,473,000 43,415,000 41,326,000 44,542,000 44,514,000 49,656,000 41,862,000 39,263,000 37,654,000 51,100,000 52,983,000 64,904,000 68,952,000 83,958,000 27,917,000 25,042,000 25,888,000 19,219,000 15,202,000 14,518,000 16,319,000 13,948,000 10,785,000 9,432,000 6,395,000 5,176,000 5,077,000 6,239,000 5,584,000 5,414,000 7,870,000 6,327,000 9,029,000 5,256,000 5,297,000 4,266,000 5,865,000 8,655,000 5,380,000 4,434,000 4,113,000 5,634,000 4,193,000 3,659,000 3,193,000 2,903,000 3,401,000 2,032,000 1,316,000 1,161,000 1,377,000 1,222,000 1,541,000 1,552,000 1,229,000 3,047,000 2,345,000 2,554,000 2,792,000      
      selling, general, and administrative
    28,777,000 34,122,000 31,655,000 43,612,000 48,090,000 78,342,000 70,747,000 101,298,000 86,798,000 155,237,000 107,460,000 93,717,000 112,532,000 161,663,000 122,876,000 108,160,000 95,992,000                                                                            
      total expenses
    154,944,000 132,909,000 248,463,000 138,170,000 151,142,000 219,391,000 218,530,000 254,486,000 238,686,000 474,910,000 312,618,000 368,969,000 393,719,000 601,278,000 861,766,000 668,885,000 494,679,000 1,047,171,000 485,988,000 643,846,000 655,861,000 462,512,000 17,494,000 52,565,000 26,274,000 37,521,000 17,494,000 40,023,000 44,205,000 52,639,000 49,635,000 52,766,000 53,166,000 58,196,000 49,980,000 48,203,000 46,506,000 59,444,000 66,539,000 79,003,000 79,480,000                                                    
      income from operations
    -15,430,000 14,230,000 -178,018,000 101,070,000 515,513,000 -131,080,000 -134,018,000 160,998,000 -144,831,000 -183,568,000 -125,632,000 55,457,000 -312,768,000 -243,879,000 -127,189,000 -482,960,000 209,292,000 -824,971,000 -307,144,000 -345,829,000 -208,632,000 -182,853,000 -14,987,000 -17,027,000 -22,897,000 -28,705,000 -14,987,000 -36,666,000 -40,223,000 -46,512,000 -41,900,000 -41,993,000 -43,513,000 -47,784,000 -41,628,000 -41,471,000 -40,826,000 -54,045,000 -63,308,000 -76,498,000 -75,262,000 -78,902,000 -33,199,000 -20,821,000 -24,313,000 -19,789,000 -17,851,000 -14,385,000 -9,545,250 -15,279,000 -12,898,000 -10,005,000 -6,849,000 -5,855,000 -7,467,000 -3,968,000 -5,921,000 -7,430,000 -10,539,000          -6,743,750 -9,257,000 -8,725,000 -8,992,000 -6,840,000 -5,694,000 -7,038,000 -5,035,000 6,708,000 -2,237,000 -5,225,000 -8,417,000 -9,908,000 -2,320,000 -7,340,000 -4,896,000 -3,060,000 -2,960,000 -4,632,000 -5,401,000 -4,166,500 -6,339,000 -5,234,000 -5,094,000 
      yoy
    -102.99% -110.86% 32.83% -37.22% -455.94% -28.59% 6.68% 190.31% -53.69% -24.73% -1.22% -111.48% -249.44% -70.44% -58.59% 39.65% -200.32% 351.17% 1949.40% 1931.06% 811.18% 537.01% 0.00% -53.56% -43.07% -38.28% -64.23% -12.69% -7.56% -2.66% 0.65% 1.26% 6.58% -11.58% -34.25% -45.79% -45.75% -31.50% 90.69% 267.41% 209.55% 298.72% 85.98% 44.74% 154.71% 29.52% 38.40% 43.78% 39.37% 160.96% 72.73% 152.14% 15.67% -21.20% -29.15%              -1.41% 62.57% 23.97% 78.59% -201.97% 154.54% 34.70% -40.18% -167.70% -3.58% -28.81% 71.92% 223.79% -21.62% 58.46% -9.35% -26.56% -53.30% -11.50% 6.03%     
      qoq
    -208.43% -107.99% -276.13% -80.39% -493.28% -2.19% -183.24% -211.16% -21.10% 46.12% -326.54% -117.73% 28.25% 91.75% -73.66% -330.76% -125.37% 168.59% -11.19% 65.76% 14.10% 1120.08% -11.98% -25.64% -20.23% 91.53% -59.13% -8.84% -13.52% 11.01% -0.22% -3.49% -8.94% 14.79% 0.38% 1.58% -24.46% -14.63% -17.24% 1.64% -4.61% 137.66% 59.45% -14.36% 22.86% 10.86% 24.09% 50.70% -37.53% 18.46% 28.92% 46.08% 16.98% -21.59% 88.18% -32.98% -20.31% -29.50%           -27.15% 6.10% -2.97% 31.46% 20.13% -19.10% 39.78% -175.06% -399.87% -57.19% -37.92% -15.05% 327.07% -68.39% 49.92% 60.00% 3.38% -36.10% -14.24% 29.63% -34.27% 21.11% 2.75%  
      operating margin %
    -11.06% 9.67% -252.70% 42.25% 77.33% -148.43% -158.58% 38.75% -154.31% -63.01% -67.19% 13.07% -386.37% -68.24% -17.31% -259.76% 29.73% -371.27% -171.74% -116.04% -46.65% -65.38% -597.81% -47.91% -678.03% -325.60% -597.81% -1092.23% -1010.12% -759.13% -541.69% -389.80% -450.77% -458.93% -498.42% -616.03% -718.77% -1001.02% -1959.39% -3053.81% -1784.31% -1348.06% -508.80% -148.76% -246.16% -240.92% -216.14% -192.78% -109.11% -318.18% -365.28% -261.02% -118.80% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% 
      other income:
                                                                                                
      interest expense
    -4,901,000 -5,824,000 -5,482,000 -5,518,000 -5,723,000 -7,585,000 -4,236,000 -4,143,000 -4,111,000 -4,117,000 -2,859,000 -3,124,000 -4,316,000 -4,601,000 -4,169,000 -6,234,000 -4,876,000 -5,138,000 -5,182,000 -5,968,000 -4,839,000 -3,879,000 -3,403,000 -3,403,000 -3,403,000 -3,403,000 -3,403,000 -3,403,000 -3,403,000 -3,403,000 -3,403,000 -3,403,000 -3,403,000 -3,523,000 -3,520,000 -3,516,000 -3,513,000 -3,508,000 -3,511,000 -3,512,000 -2,430,000 -115,000 -64,000 -26,000 -36,000 -47,000 -51,000 -52,000 -28,000 -64,000 -45,000 -22,000 -6,000 -3,000 -3,000 -2,000 -2,000 -2,000 -2,000 -2,000 -2,000        -283,000 -458,000  604,000 -348,000 -341,000  -460,000 -553,000 -490,000 -491,000 -469,000 -451,000 -337,000 -377,000 -362,000 -23,000 -401,000 -396,000 -401,000 221,500 375,000 263,000 -248,000 
      other income
    11,825,000 9,497,000 9,178,000 11,902,000 10,056,000 13,135,000 15,922,000 7,731,000 3,654,000 10,984,000 -2,982,000 5,532,000 24,362,000   -19,873,000 1,654,000 131,000 -4,394,000 2,659,000  9,026,000 5,000 2,612,000  2,000 5,000 -8,000 -12,000 -3,000 -19,000 97,000 33,000 47,000 10,000 -1,000 11,000 2,000 11,000 -11,000    72,000 -142,000 -19,000 18,000  192,000 -10,000         136,000   732,000 -710,000 -1,212,000                             
      income before income tax expense
    -8,506,000 17,903,000 -203,036,000 107,454,000 519,846,000   164,586,000    57,865,000 -292,722,000   -509,067,000 206,070,000                                                                            
      income tax expense
    985,000 -3,354,000 -657,000 946,000 1,200,000 -14,319,000 -1,032,000 2,205,000 2,262,000 -2,374,000 -697,000 -143,000 1,183,000 -2,260,000 2,472,000 1,418,000 2,662,000 16,609,000 6,041,000 3,548,000 3,017,000                            3,000  5,000 17,000     412,000                                    
      net income
    -9,491,000 17,527,000 -202,379,000 106,508,000 518,646,000 -81,030,000 -121,300,000 162,381,000 -147,550,000 -178,389,000 -130,776,000 58,008,000 -293,905,000 -182,249,000 -168,613,000 -510,485,000 203,408,000 -846,284,000 -322,431,000 -352,317,000 -222,719,000 -177,564,000 -18,043,000 -17,521,000 -25,864,000 -31,830,000 -18,043,000 -39,603,000 -43,218,000 -49,334,000 -44,570,000 -44,492,000 -46,352,000 -50,842,000 -44,607,000 -44,465,000 -43,854,000 -57,109,000 -66,254,000 -79,351,000 -77,252,000 -78,806,000 -33,120,000 -20,641,000 -24,370,000 -19,727,000 -17,864,000 -13,810,000 -14,054,000 -15,300,000 -12,633,000 -9,996,000 -7,217,000 -5,920,000 -7,336,000 -3,212,000 -4,993,000 -7,453,000 -10,355,000 -9,426,000 -11,412,000 -7,530,000 -8,540,000 -8,349,000 -6,242,250 -7,842,000 -9,372,000 -7,755,000 -6,387,000 -8,966,000 -8,194,000 -8,388,000 -6,148,000 -5,014,000 -6,411,000 -5,495,000 6,155,000 -2,727,000 -5,716,000 -8,886,000 -10,289,000 -2,657,000 -7,717,000 -5,258,000 -3,083,000 -3,361,000 -5,028,000 -5,802,000 -4,388,000 -6,714,000 -5,497,000 -5,342,000 
      yoy
    -101.83% -121.63% 66.84% -34.41% -451.51% -54.58% -7.25% 179.93% -49.80% -2.12% -22.44% -111.36% -244.49% -78.46% -47.71% 44.89% -191.33% 376.61% 1687.01% 1910.83% 761.12% 457.85% 0.00% -55.76% -40.15% -35.48% -59.52% -10.99% -6.76% -2.97% -0.08% 0.06% 5.70% -10.97% -32.67% -43.96% -43.23% -27.53% 100.04% 284.43% 217.00% 299.48% 85.40% 49.46% 73.40% 28.93% 41.41% 38.16% 94.73% 158.45% 72.21% 211.21% 44.54% -20.57% -29.15% -65.92% -56.25% -1.02% 21.25% 12.90% 82.82% -3.98% -8.88% 7.66% -2.27% -12.54% 14.38% -7.55% 3.89% 78.82% 27.81% 52.65% -199.89% 83.87% 12.16% -38.16% -159.82% 2.63% -25.93% 69.00% 233.73% -20.95% 53.48% -9.38% -29.74% -49.94% -8.53% 8.61%     
      qoq
    -154.15% -108.66% -290.01% -79.46% -740.07% -33.20% -174.70% -210.05% -17.29% 36.41% -325.44% -119.74% 61.27% 8.09% -66.97% -350.97% -124.04% 162.47% -8.48% 58.19% 25.43% 884.12% 2.98% -32.26% -18.74% 76.41% -54.44% -8.36% -12.40% 10.69% 0.18% -4.01% -8.83% 13.98% 0.32% 1.39% -23.21% -13.80% -16.51% 2.72% -1.97% 137.94% 60.46% -15.30% 23.54% 10.43% 29.36% -1.74% -8.14% 21.11% 26.38% 38.51% 21.91% -19.30% 128.39% -35.67% -33.01% -28.03% 9.86% -17.40% 51.55% -11.83% 2.29% 33.75% -20.40% -16.33% 20.85% 21.42% -28.76% 9.42% -2.31% 36.43% 22.62% -21.79% 16.67% -189.28% -325.71% -52.29% -35.67% -13.64% 287.24% -65.57% 46.77% 70.55% -8.27% -33.15% -13.34% 32.22% -34.64% 22.14% 2.90%  
      net income margin %
    -6.80% 11.91% -287.29% 44.52% 77.80% -91.76% -143.53% 39.08% -157.21% -61.23% -69.94% 13.67% -363.07% -50.99% -22.95% -274.57% 28.89% -380.87% -180.29% -118.22% -49.80% -63.49% -719.70% -49.30% -765.89% -361.05% -719.70% -1179.71% -1085.33% -805.19% -576.21% -413.00% -480.18% -488.30% -534.09% -660.50% -772.08% -1057.77% -2050.57% -3167.70% -1831.48% -1346.42% -507.59% -147.48% -246.73% -240.16% -216.30% -185.07% -160.65% -318.62% -357.77% -260.79% -125.19% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% 
      net income per share
                                                                 -0.08 -0.1 -0.12 -0.1 -0.12 -0.15 -0.13                         
      basic
    -0.06 0.11 -1.25 0.66 3.22   1.09    0.65 -3.41   -6.53 2.66                                                                            
      diluted
    -0.06 0.05 -1.25 0.62 2.93   0.99    0.58 -3.41    2.56                                                                            
      weighted-average number of common shares outstanding:
                                                                                                
      basic
    163,276 161,991 162,353 162,019 161,049   148,379    89,362 86,158   78,143 76,457                                                                            
      diluted
    163,276 173,103 162,353 177,215 177,625   165,855    104,065 86,158    80,711                                                                            
      impairment of assets held for sale
     807,000 97,038,000                                                                                          
      loss on debt extinguishment
      -28,714,000                                                                                          
      grants
             37,943,000 164,922,000 137,079,000 87,379,000 69,573,000 106,273,000 107,774,000 99,301,000                                                                            
      loss before income tax expense
         -73,581,000 -122,332,000       -184,509,000 -166,141,000                                                                              
      net income per share
                                                                 -0.08 -0.1 -0.12 -0.1 -0.12 -0.15 -0.13                         
      basic and diluted
         -0.52 -0.76  -1.05 -1.47 -1.26   -2.29 -2.15                                                                              
      weighted-average number of common shares outstanding:
                                                                                                
      basic and diluted
         152,190 160,049  139,916 100,768 103,429   78,183 78,274                                                                              
      royalties and other
            11,531,000 1,947,000 19,833,000 2,184,000 1,029,000 39,000 2,213,000 22,696,000 19,042,000                                                                            
      income before income taxes
            -145,288,000 -91,582,500 -131,473,000                                                                                  
      weighted-average number of common shares outstanding
                                                                                                
      basic and diluted
         152,190 160,049  139,916 100,768 103,429   78,183 78,274                                                                              
      weighted-average number of common shares outstanding
                                                                                                
      basic
    163,276 161,991 162,353 162,019 161,049   148,379    89,362 86,158   78,143 76,457                                                                            
      diluted
    163,276 173,103 162,353 177,215 177,625   165,855    104,065 86,158    80,711                                                                            
      other expense:
                                                                                                
      other expense
                 -13,250,500 -34,783,000      -6,593,000                    -33,000 -30,250 -51,000                                                  
      net income per share
                                                                 -0.08 -0.1 -0.12 -0.1 -0.12 -0.15 -0.13                         
      basic
    -0.06 0.11 -1.25 0.66 3.22   1.09    0.65 -3.41   -6.53 2.66                                                                            
      weighted-average number of common shares outstanding
                                                                                                
      basic
    163,276 161,991 162,353 162,019 161,049   148,379    89,362 86,158   78,143 76,457                                                                            
      government contracts
                     180,185,000 97,502,000 240,534,000 382,704,000                 2,000 102,000 134,000 1,946,000 4,071,000 6,307,000 13,720,000 9,246,000 7,504,000 7,241,000 5,472,000 6,723,000 4,268,000 3,276,000 3,441,000 5,583,000                                        
      grant and other
                     34,988,000 41,401,000 34,026,000 64,525,000 38,172,500 2,507,000 35,538,000 3,377,000 1,316,000 2,507,000 3,357,000 3,982,000 6,127,000 7,735,000 10,773,000 9,653,000                                                            
      royalties
                     15,849,500 39,941,000 23,457,000                                                                         
      general and administrative
                     84,214,000 77,793,000 73,161,000 63,190,000 61,313,000 7,899,000 17,719,000 9,379,000 8,181,000 7,899,000 9,606,000 8,732,000 9,224,000 8,309,000 8,224,000 8,652,000 8,540,000 8,118,000 8,940,000 8,852,000 8,344,000 13,556,000 14,099,000 10,528,000 8,851,000 9,060,000 7,088,000 5,843,000 4,757,000 5,806,000 4,308,000 4,079,000 3,857,000 4,012,000 2,694,000 2,381,000 2,664,000 3,246,000 2,737,000 3,338,000 2,850,000 2,844,000 3,148,000 2,535,000 3,207,000 2,562,000  1,918,750 1,265,000 3,166,000 3,244,000 2,761,000 3,085,000   3,327,000 2,530,000 2,610,000 2,720,000 2,005,000 1,694,000 2,292,000 2,121,000 2,724,000 1,901,000 2,059,000 2,032,000 2,373,000 1,911,000 1,810,000      
      investment income
                     303,000 330,000 369,000 362,000 142,000 342,000 297,000 436,000 276,000 342,000 474,000 420,000 584,000 752,000 807,000 531,000 418,000 531,000 523,000 474,000 442,000 554,000 670,000 473,000 210,000 194,000 134,000 121,000                                                
      net loss before income tax expense
                     -221,215,250 -316,390,000 -348,769,000 -219,702,000                                                                        
      basic and diluted net loss per share
                     -11.31 -4.31 -4.75 -3.05 -2.88 -0.74 -0.3 -0.58 -1.08 -0.74 -1.69 -0.11 -0.13 -0.12 -0.12 -0.14 -0.16 -0.15 -0.16 -0.16 -0.21 -0.24 -0.29 -0.29 -0.3 -0.12   -0.08 -0.08                                            -0.22 -0.22 
      basic and diluted weighted-average number of common shares outstanding
                     74,400 74,745 74,118 73,035 57,554 24,327 58,618 44,421 24,100 24,327 23,473  369,757 382,315 375,923 336,972 292,669 296,435 283,444  270,802 271,064 270,760 270,179 262,248 269,554 268,083 241,223 238,304 217,178  169,658 168,537 152,312 148,448 134,178 126,925 120,558 115,107 112,821 111,188 107,092 100,694 100,188 92,297,263 84,832,226 68,692,455  66,521,776 61,329,699 61,280,155  61,399,445 61,311,954 61,221,075   61,465,003 52,267,386 42,758,302 43,469,637 39,553,876 39,553,876 36,926,034 38,577,458 34,779,657 34,722,402 29,852,797  29,988,875 26,990,427     
      government contract
                         10,812,250                                                                       
      gain on catalent transaction
                          -9,016,000    -9,016,000                                                                  
      basic and diluted weighted average number of common shares outstanding
                                408,843        274,178                                                        
      research and development collaborations
                                     5,191,000 8,352,000 6,732,000 5,680,000 5,397,000 3,129,000 2,371,000 2,272,000 1,782,000 218,000 276,000 631,000 710,000 1,018,000 1,990,000 2,025,000 534,000 255,000 392,000                                         
      costs and expenses:
                                                                                                
      cost of government contracts revenue
                                             2,013,500 2,747,000 2,687,000 2,459,000 4,027,000 5,102,000 3,021,000 2,603,000 2,276,000 1,632,000 1,712,000 3,838,000                                        
      total costs and expenses
                                             27,182,750 39,724,000 34,817,000 34,190,000 28,003,000 26,110,000 21,847,000 23,001,000 20,081,000 16,429,000 13,838,000 12,614,000 12,958,000 12,109,000                                      
      realized gains on marketable securities
                                                                                                
      basic and diluted net income per share
                                               -0.08 -0.1   -0.07 -0.06 -0.09 -0.08 -0.07 -0.05 -0.05 -0.06 -0.03 -0.04 -0.07 -0.1 -0.09 -0.11            -0.073 -0.08           -0.123 -0.11   -0.18 -0.27   
      interest income
                                                 128,000 20,000 12,000 38,000 53,000 48,000 48,000 39,000 39,000 33,000 22,000 38,000 46,000 50,000 44,000 44,000    -149,250 -604,000 -110,000 117,000 639,750 749,000 531,000  -700,000 1,021,000                   
      change in fair value of warrant liability
                                                      267,000  -401,000 -101,000 101,000 736,000 1,304,000 -67,000                                   
      realized gains on investments
                                                   615,000                                             
      loss from operations before income tax
                                                 -19,727,000 -17,864,000                                              
      income from operations before income tax
                                                   -13,810,000 -9,476,750 -15,300,000 -12,628,000 -9,979,000 -7,217,000 -5,920,000  -3,212,000 -4,581,000                                    
      basic and diluted weighted-average number of common shares outstanding
                                                   208,927                                             
      research and development collaboration
                                                        182,000                                        
      contract revenue
                                                         7,103,000 4,642,000                                      
      cost of contract revenue
                                                         5,118,000 3,786,000                                      
      revenue
                                                           5,008,000 3,001,000 834,000 175,000 7,000 110,000                                
      operating expenses:
                                                                                                
      total operating expenses
                                                           8,976,000 8,922,000 8,264,000 10,714,000 9,475,000 11,564,000                                
      income tax (benefit) expense
                                                                                                
      impairment of short-term investments
                                                                                                
      realized gains on short-term investments
                                                                                                
      income from continuing operations
                                                               -9,468,000 -11,454,000 -7,530,000 -8,540,000 -8,349,000 -6,436,750 -10,330,000 -8,314,000 -7,103,000                         
      revenues
                                                                 201,000 29,000 21,000                             
      operating costs and expenses:
                                                                                                
      total operating costs and expenses
                                                                 8,463,000 7,859,000 7,158,000 6,536,000 9,920,000 8,546,000 7,678,000 7,279,250 10,572,000 8,883,000 9,660,000 8,188,000 6,887,000 7,877,000 6,338,000 -4,464,000 4,104,000 7,540,000 9,379,000 11,954,000 2,309,000 10,345,000 8,116,000         
      income from operations before other income
                                                                 -8,262,000 -7,830,000                              
      income from discontinued operations
                                                                    194,500 2,488,000 -1,058,000 -652,000                         
      basic and diluted net income per share:
                                                                                                
      loss per share from continuing operations
                                                                 -0.08 -0.1 -0.12 -0.103 -0.16  -0.12                         
      income per share from discontinued operations
                                                                                                
      net income per share
                                                                 -0.08 -0.1 -0.12 -0.1 -0.12 -0.15 -0.13                         
      loss per share from discontinued operations
                                                                      -0.02 -0.01                         
      selling, general and administrative
                                                                   2,892,000       3,362,000 4,597,000                     
      income from continuing operations before other income
                                                                   -7,137,000                             
      revenues:
                                                                                                
      net product sales
                                                                        169,500 453,000 -64,000 357,000 833,000 571,000 378,000 719,000 641,000 1,300,000 1,889,000 719,000 2,207,000 -664,000 2,656,000 2,197,000         
      contract research and development
                                                                    231,250 142,000 325,000 458,000 242,000 710,000 110,000 222,000 427,000 582,000 403,000 474,000 712,000 417,000 426,000 243,000 -161,000 653,000 286,000 960,000 284,000 560,000 253,000      
      royalties, milestone and licensing fees
                                                                    17,250 52,000 17,000     89,000 88,000 40,000 58,000 110,000                 
      total revenues
                                                                    248,500 194,000 342,000 458,000 -687,000 1,315,000 158,000 668,000 1,348,000 1,193,000 839,000 1,303,000 2,244,000 1,867,000 2,315,000 962,000 2,046,000 -11,000 3,005,000 3,220,000         
      cost of products sold
                                                                        -3,106,000 1,096,000 855,000 1,317,000 1,360,000 1,170,000 1,161,000 1,233,000 717,000 1,068,000 2,027,000 1,979,000 1,362,000 364,000 1,501,000 263,000         
      income from continuing operations before interest income
                                                                    -6,287,500 -9,726,000 -8,204,000 -7,220,000                         
      gain per share from discontinued operations
                                                                    0.003 0.04                           
      basic and diluted net income per share: loss per share from continuing operations
                                                                      -0.14                          
      basic and diluted loss per share:
                                                                                                
      royalties and milestone fees
                                                                        79,500 152,000                       
      excess inventory costs over market
                                                                        329,250 757,000 473,000 87,000 293,000 264,000 677,000 315,000                 
      basic and diluted loss per share
                                                                        -0.105 -0.15 -0.13 -0.14   -0.1 -0.11 0.16 -0.06 -0.14 -0.22 -0.27 -0.07 -0.22 -0.15   -0.17 -0.22     
      royalities, milestone and licensing fees
                                                                          112,000                      
      selling and marketing
                                                                            15,000 20,000 28,000 38,000 88,000 930,000 1,844,000 4,057,000 6,327,000 8,931,000 5,556,000 2,774,000         
      facility exit costs
                                                                                 107,000    723,000           
      gain on sale of product assets
                                                                                -214,000 -856,000               
      total other income
                                                                            211,750 680,000                   
      weighted-average number of common shares used in computing basic and diluted net income per share
                                                                            58,664,365 61,500,942                   
      interest income / (expense)
                                                                              627,000                  
      milestone and licensing fees
                                                                                37,500 150,000     63,000 63,000 63,000 62,000 63,000     813,000 
      gain on redemption of debt
                                                                                     -11,162,000           
      basic and diluted weighted-average number of common outstanding
                                                                                         30,134,586       
      operating costs and expense:
                                                                                                
      weighted-average shares used for eps calculation
                                                                                             24,653,759 24,563,612 23,851,186 
      contract research & development
                                                                                               505,000 
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2011-09-30 2011-06-30 2011-03-31 2010-09-30 2010-06-30 2010-03-31 2009-09-30 2009-06-30 2009-03-31 2008-12-31 2008-09-30 2008-06-30 2008-03-31 2007-12-31 2007-09-30 2007-06-30 2007-03-31 2006-12-31 2006-09-30 2006-06-30 2006-03-31 2005-12-31 2005-09-30 2005-06-30 2005-03-31 2004-12-31 2004-09-30 2004-06-30 2004-03-31 2003-12-31 2003-09-30 2003-06-30 2003-03-31 2002-12-31 2002-09-30 2002-06-30 2002-03-31 2001-12-31 2001-09-30 2000-12-31 
                                                                                                
        assets
                                                                                                
        current assets:
                                                                                                
        cash and cash equivalents
      228,363,000 240,634,000 268,023,000 253,744,000 263,338,000 530,230,000 573,630,000 680,162,000 480,586,000 568,505,000 651,104,000 505,912,000 624,950,000 1,336,883,000 1,280,581,000 1,375,587,000 1,570,954,000 1,515,116,000 1,936,998,000 2,074,880,000 1,995,482,000 553,398,000 334,171,000 424,395,000 179,881,000 78,823,000 71,167,000 71,995,000 97,711,000 70,154,000 56,496,000 88,475,000 113,402,000 106,307,000 104,245,000 75,793,000 95,847,000 144,353,000 119,948,000 89,395,000 132,225,000 93,108,000 138,144,000 167,384,000 215,050,000 34,473,000 103,857,000 109,921,000 119,471,000 122,493,000 14,318,000 13,092,000 8,358,000 16,215,000 9,446,000 14,575,000 29,984,000 25,216,000 19,629,000 26,938,000 36,794,000 23,513,000 14,702,000 4,350,000 15,816,000 7,337,000 7,782,000 7,161,000 21,294,000 78,601,000 83,941,000 31,893,000 6,944,000 4,442,000 9,202,000 17,876,000 27,503,000 15,623,000  27,633,000 6,045,000 9,625,000 14,320,000 3,005,000 7,630,000 15,927,000 10,885,000  23,296,000  
        marketable securities
      561,969,000 494,450,000 494,871,000 358,560,000 468,141,000 392,888,000 335,901,000 369,432,000             2,250,000 157,649,000 169,860,000 77,902,000 57,474,000    2,484,000 21,980,000 70,612,000 78,636,000 30,358,000 50,996,000 68,321,000 111,515,000 115,331,000 91,126,000 180,335,000 276,967,000 301,642,000 137,548,000 152,042,000 147,554,000 112,685,000                                              
        restricted cash
       10,876,000 10,816,000 10,749,000 10,681,000 10,626,000 10,547,000 10,486,000 10,455,000 10,424,000 10,393,000 10,361,000 10,330,000 10,303,000 10,785,000 10,274,000 11,492,000 11,490,000 8,175,000 46,398,000 32,128,000 93,880,000 67,154,000 106,768,000 6,900,000 2,947,000 4,355,000 5,030,000 6,628,000 10,847,000 17,586,000 10,132,000 19,548,000 28,234,000 32,422,000 30,188,000 27,319,000 30,314,000 31,521,000 33,312,000 29,619,000 34,964,000     203,000 336,000 1,417,000 124,000                                         
        accounts receivable
      23,312,000 106,446,000 34,174,000 226,396,000 44,510,000 108,285,000 94,962,000 32,105,000 21,380,000 297,240,000 123,657,000 394,890,000 112,849,000 82,375,000 111,645,000 194,533,000 478,156,000 454,993,000 75,283,000 49,989,000 56,898,000 262,012,000 12,355,000   7,500,000            233,000 591,000 363,000 406,000       4,466,000                                 2,860,000 1,872,000   1,514,000 3,273,000 3,902,000  3,012,000  
        inventory
      11,458,000 11,545,000 13,511,000 10,240,000 10,263,000 8,749,000 8,638,000 9,172,000 15,778,000 41,696,000 69,592,000 23,488,000 34,185,000 36,683,000 82,432,000 256,301,000 106,648,000                                           42,000 55,000 47,000 43,000 25,000 498,000 444,000 735,000 600,000 900,000 757,000 780,000 800,000 1,651,000 1,400,000 2,372,000 3,464,000 2,278,000 747,000 872,000 855,000 731,000 801,000 630,000 633,000 930,000 655,000 906,000  659,000  
        prepaid expenses and other current assets
      25,714,000 26,815,000 45,532,000 59,823,000 71,095,000 78,164,000 80,002,000 102,013,000 198,921,000 226,023,000 152,018,000 192,903,000 188,714,000 237,147,000 274,522,000 299,307,000 180,155,000 173,520,000 119,047,000 162,351,000 114,731,000 181,264,000 83,851,000 27,316,000 10,977,000 7,977,000 13,500,000 11,630,000 16,571,000 16,295,000 15,847,000 17,092,000 17,726,000 17,774,000 21,007,000 19,187,000 19,952,000 21,804,000 21,510,000 19,944,000 20,703,000 19,317,000 15,582,000 13,201,000 11,489,000       2,243,000 1,702,000 348,000 452,000 698,000 387,000 806,000 994,000 732,000 529,000 1,339,000 1,039,000 1,304,000 958,000 1,033,000 1,796,000 1,873,000 930,000 1,306,000 1,128,000 1,347,000 962,000 1,329,000 1,373,000 1,770,000 899,000 2,908,000 1,545,000 1,614,000 611,000 539,000 538,000 722,000 1,915,000 1,907,000 1,659,000  804,000  
        assets held for sale
       87,510,000 107,663,000                         21,563,000                                 899,000 899,000 899,000 899,000                           
        total current assets
      850,816,000 978,276,000 974,590,000 919,512,000 868,028,000 1,128,942,000 1,103,680,000 1,203,370,000 727,120,000 1,143,888,000 1,006,764,000 1,127,554,000 971,028,000 1,703,391,000 1,759,965,000 2,136,002,000 2,347,405,000 2,155,119,000 2,174,181,000 2,354,992,000 2,246,784,000 1,248,203,000 671,217,000 636,381,000 255,232,000 97,247,000 89,022,000 110,218,000 123,394,000 119,276,000 160,541,000 194,335,000 181,034,000 203,311,000 225,995,000 236,683,000 258,449,000 287,830,000 353,905,000 419,981,000 484,595,000 287,257,000 310,102,000 332,979,000 350,094,000 191,979,000 166,602,000 128,873,000 145,001,000 155,020,000 26,253,000 28,416,000 28,976,000 37,810,000 27,594,000 33,817,000 34,935,000 32,041,000 26,642,000 35,096,000 46,681,000 38,309,000 43,036,000 49,016,000 55,317,000 63,480,000 71,066,000 77,342,000 80,100,000 84,489,000 89,450,000 37,611,000 10,704,000 8,304,000 13,573,000 23,937,000 32,460,000 22,577,000 26,620,000 32,062,000           
        property and equipment
      42,149,000 44,800,000 49,120,000 129,643,000 133,538,000 138,413,000 285,724,000 288,559,000 291,093,000 305,771,000 300,982,000 299,955,000 307,414,000 294,247,000 255,532,000 254,526,000 247,213,000 228,696,000 214,751,000 213,186,000 192,044,000 179,954,000 131,834,000 115,375,000 10,795,000 11,445,000 12,244,000 12,987,000 26,972,000 28,426,000 29,343,000 30,829,000 32,422,000 35,987,000 37,299,000 38,531,000 39,439,000 40,184,000 40,955,000 39,668,000 36,558,000 32,342,000 29,421,000 26,134,000 23,967,000 17,492,000 15,124,000 14,270,000 14,251,000 13,969,000 7,531,000 7,629,000 7,859,000 8,203,000 8,050,000 8,259,000 7,644,000 7,879,000 8,019,000 8,228,000 8,365,000 7,940,000 7,874,000 5,721,000 9,381,000 9,555,000 9,710,000 9,861,000 10,237,000 10,761,000 11,103,000 11,589,000 12,116,000 12,759,000 13,447,000 14,147,000 14,568,000 15,117,000 15,347,000 15,244,000 14,275,000 13,840,000 13,858,000 13,655,000 12,968,000 10,852,000 7,939,000  2,513,000  
        right-of-use asset
      21,358,000 22,897,000                                                                                         
        goodwill
      112,888,000 113,462,000 113,080,000 112,958,000 112,027,000 107,478,000 126,766,000 123,377,000 123,179,000 127,454,000 123,780,000 128,366,000 129,827,000 126,331,000 117,535,000 123,467,000 130,756,000 131,479,000 131,989,000 134,294,000 130,879,000 135,379,000 126,932,000 118,849,000 49,988,000 51,154,000 50,305,000 51,280,000 51,245,000 51,967,000 52,072,000 51,983,000 53,286,000 53,563,000 53,746,000 52,991,000 51,941,000 51,673,000 52,694,000 52,941,000 53,766,000 53,065,000 53,062,000 53,307,000 52,664,000 56,174,000 57,906,000 58,621,000 59,519,000 58,759,000 33,141,000 33,141,000 33,141,000 33,141,000 33,141,000 33,141,000 33,141,000 33,141,000 33,141,000 33,141,000 33,141,000 33,141,000 33,141,000 33,141,000 33,141,000 33,141,000 33,141,000 33,141,000 33,141,000 33,141,000 33,141,000 33,141,000 33,141,000 33,141,000 33,141,000 33,141,000 33,141,000 33,141,000 33,141,000 33,141,000 33,141,000 33,141,000 33,141,000 33,141,000       
        other non-current assets
      15,951,000 17,077,000 19,226,000 21,392,000 21,904,000 24,000,000 30,547,000 33,833,000 30,967,000 35,159,000 34,890,000 33,434,000 30,507,000 28,469,000 17,406,000 19,195,000 18,614,000 56,689,000 38,340,000 40,373,000 31,929,000 11,758,000 8,294,000 55,961,000 6,590,000 7,120,000 7,362,000 7,736,000 11,734,000 810,000 814,000 811,000 859,000 869,000 876,000 847,000 809,000 799,000 410,000 410,000 137,000 1,044,000 1,044,000 918,000 918,000 159,000 159,000 159,000 159,000 164,000 160,000 160,000 160,000 160,000 160,000 160,000 160,000 160,000 160,000 160,000 175,000 208,000 771,000 880,000 988,000 951,000 528,000 555,000 892,000 1,141,000  931,000    1,720,000               
        total assets
      1,043,162,000 1,176,512,000 1,179,889,000 1,336,549,000 1,292,992,000 1,560,418,000 1,712,483,000 1,818,646,000 1,353,534,000 1,797,490,000 1,657,157,000 1,685,048,000 1,542,699,000 2,258,679,000 2,267,437,000 2,622,993,000 2,834,875,000 2,576,753,000 2,565,941,000 2,749,587,000 2,608,366,000 1,582,479,000 944,020,000 932,227,000 328,068,000 172,957,000 164,810,000 189,389,000 221,319,000 207,978,000 250,478,000 285,807,000 276,067,000 302,493,000 334,077,000 355,706,000 361,504,000 394,301,000 459,626,000 525,004,000 592,507,000 386,038,000 404,634,000 424,698,000 438,841,000 292,514,000 311,991,000 218,599,000 235,937,000 245,074,000 67,085,000 69,346,000 70,136,000 79,314,000 68,945,000 75,377,000 75,880,000 73,221,000 67,962,000 76,625,000 89,519,000 80,777,000 86,221,000 91,291,000 99,706,000 108,039,000 115,390,000 121,877,000 125,381,000 130,576,000 135,432,000 84,382,000 60,546,000 60,298,000 66,578,000 77,993,000 87,600,000 74,617,000 78,800,000 84,159,000           
        liabilities and stockholders’ deficit
                                                                                                
        current liabilities:
                                                                                                
        accounts payable
      16,101,000 24,578,000 15,227,000 50,595,000 34,162,000 41,579,000 57,517,000 79,962,000 57,724,000 132,610,000 101,914,000 87,246,000 124,801,000 216,517,000 144,997,000 386,488,000 135,128,000 127,050,000 59,564,000 73,995,000 113,605,000 54,332,000 15,097,000 9,242,000 2,518,000 2,910,000 4,210,000 4,303,000 6,150,000 9,301,000 6,790,000 6,686,000 5,770,000 5,613,000 5,242,000 8,021,000 3,790,000 5,685,000 16,231,000 15,991,000 11,237,000 11,889,000 8,201,000 7,117,000 9,742,000 2,975,000 4,495,000 4,018,000 5,985,000 3,339,000 2,395,000 2,961,000 3,362,000 3,350,000 3,433,000 5,474,000 1,544,000 1,460,000 1,024,000 1,750,000 1,967,000 729,000 2,186,000 1,490,000 2,359,000 2,479,000 1,764,000 1,530,000 884,000 780,000 811,000 1,426,000 753,000 1,230,000 1,518,000 3,242,000 4,114,000 4,058,000 2,364,000 2,342,000 2,201,000 1,694,000 1,599,000 2,534,000 2,584,000 4,318,000 1,826,000  1,483,000  
        accrued expenses
      103,027,000 107,165,000 115,586,000 86,697,000 132,165,000 211,165,000 218,674,000 159,221,000 257,365,000 394,668,000 311,201,000 458,397,000 518,706,000 591,158,000 551,069,000 585,646,000 559,876,000 673,731,000 323,867,000 249,178,000 148,611,000 137,390,000 78,812,000 38,690,000 10,004,000 14,867,000 11,553,000 13,907,000 13,881,000 19,550,000 20,963,000 22,042,000 19,225,000 29,610,000 28,150,000 22,305,000 24,650,000 24,508,000 26,098,000 26,522,000 27,147,000 26,734,000 13,270,000 16,522,000 15,590,000                 3,690,000 2,239,000  2,470,000 2,516,000 2,612,000  2,500,000 2,813,000 2,084,000 2,597,000 3,488,000 3,747,000 3,680,000 4,140,000 3,374,000 3,368,000 1,381,000 1,179,000 2,572,000 2,021,000 2,576,000 2,844,000 3,822,000 3,031,000 4,972,000  2,662,000  
        deferred revenue
      88,772,000 140,053,000 104,251,000 113,763,000 108,334,000 675,067,000 613,418,000 666,390,000 240,900,000 241,310,000 192,187,000 300,473,000 415,764,000 370,137,000 404,776,000 701,518,000 1,094,232,000 1,422,944,000 1,262,360,000 1,220,073,000 822,809,000 273,228,000 81,814,000 158,851,000 3,113,000 1,678,000 2,590,000 4,188,000 5,943,000 10,010,000 15,365,000 7,683,000 16,377,000 25,625,000 31,464,000 30,028,000 24,679,000 30,079,000 30,157,000 32,807,000 28,907,000 34,469,000 2,500,000 2,500,000 2,500,000 3,000 25,000 57,000 271,000 190,000 2,500,000 2,500,000 2,500,000 7,000 54,000 61,000                                 2,688,000  
        current portion of finance lease liabilities
      2,112,000 2,507,000 5,036,000 5,552,000 5,478,000 7,009,000 9,675,000 9,427,000 6,291,000 5,142,000 1,332,000 953,000 1,205,000 27,196,000 82,095,000 124,260,000 116,684,000 130,533,000 103,987,000 98,383,000 121,144,000 105,862,000 55,860,000                                                                    
        other current liabilities
      132,449,000 137,778,000 138,334,000 132,531,000 142,031,000 219,596,000 281,715,000 242,811,000 242,102,000 861,408,000 861,956,000 749,186,000 858,382,000 930,055,000 160,499,000 34,158,000 31,271,000 36,061,000 3,637,000 9,887,000 2,386,000 3,782,000 5,604,000 1,470,000 1,316,000 1,262,000 1,191,000 1,140,000 3,491,000 1,600,000 1,566,000 1,530,000 1,501,000 7,749,000 1,390,000 1,359,000 1,348,000 1,056,000 55,000 73,000 72,000 1,598,000 1,697,000 1,695,000 1,704,000                                              
        liabilities held for sale
       47,869,000 51,435,000                         12,872,000                                                               
        total current liabilities
      342,461,000 459,950,000 429,869,000 389,138,000 422,170,000 1,154,416,000 1,180,999,000 1,157,811,000 804,382,000 1,635,138,000 1,468,590,000 1,596,255,000 1,918,858,000 2,459,944,000 1,667,961,000 2,156,239,000 2,261,005,000 2,390,319,000 1,753,415,000 1,651,516,000 1,208,555,000 579,672,000 239,218,000 213,331,000 18,982,000 25,795,000 21,575,000 41,488,000 31,496,000 45,539,000 46,715,000 43,019,000 44,904,000 73,675,000 68,277,000 66,791,000 56,498,000 66,406,000 75,684,000 81,878,000 71,051,000 76,494,000 24,873,000 27,053,000 28,776,000 18,635,000 17,479,000 13,715,000 18,934,000 14,260,000 6,741,000 8,995,000 11,126,000 9,528,000 8,523,000 9,233,000 5,647,000 10,192,000 26,832,000 27,717,000 30,185,000 9,029,000 8,325,000 6,206,000 5,617,000 5,645,000 5,674,000 5,339,000 3,616,000 4,033,000 3,543,000 4,876,000 4,708,000 5,631,000 6,130,000 8,576,000 7,845,000 8,111,000 4,777,000 4,836,000           
        long-term debt
      291,039,000                                                                                          
        non-current finance lease liabilities
      1,907,000 2,091,000 2,269,000 52,370,000 53,055,000 53,726,000 54,368,000 54,970,000 54,609,000 55,923,000 53,158,000 30,744,000 30,993,000 31,238,000 31,474,000     9,193,000 16,696,000 40,083,000 63,099,000                                                                    
        other non-current liabilities
      193,244,000 239,068,000 263,483,000 287,585,000 313,727,000 359,614,000 318,917,000 335,292,000 351,722,000 33,130,000 37,296,000 38,383,000 47,511,000 55,695,000 98,569,000 69,075,000 66,798,000 42,121,000 28,088,000 20,570,000 21,598,000 13,480,000 11,262,000 10,725,000 9,590,000 10,068,000 10,318,000 10,752,000 17,464,000 8,687,000 9,112,000 9,520,000 9,913,000 10,287,000 16,434,000 15,449,000 14,910,000 14,602,000 3,434,000 3,330,000 3,248,000 3,170,000 3,094,000 73,000 91,000 1,399,000 1,507,000 1,562,000 1,568,000 1,578,000                                         
        total liabilities
      1,187,924,000 1,304,265,000 1,336,561,000 1,298,924,000 1,368,635,000 2,184,259,000 2,238,919,000 2,250,352,000 2,220,618,000 2,514,417,000 2,335,507,000 2,439,567,000 2,438,281,000 2,892,757,000 2,833,422,000 3,039,943,000 2,769,551,000 2,928,426,000 2,104,605,000 2,004,025,000 1,569,239,000 955,270,000 637,758,000 547,879,000 352,039,000 358,974,000 354,648,000 374,882,000 371,902,000 375,913,000 377,157,000 373,514,000 375,436,000 404,225,000 408,228,000 414,768,000 390,603,000 399,847,000 409,842,000 414,887,000 407,074,000 93,369,000 37,618,000 37,095,000 39,135,000 30,864,000 30,260,000 27,539,000 32,703,000 28,500,000 12,488,000 13,075,000 16,607,000 12,321,000 11,422,000 12,238,000 8,863,000 13,500,000 30,168,000 31,136,000 33,387,000 33,556,000 30,426,000 28,226,000 27,823,000 27,780,000 28,278,000 27,876,000 26,242,000                      
        commitments and contingencies
                                                                                                
        preferred stock, 0.01 par value...
                            199,822,000 199,822,000                                                                   
        stockholders' deficit:
                                                                                                
        common stock, 0.01 par value...
      1,678,000 1,650,000 1,648,000 1,645,000 1,642,000 1,619,000 1,616,000 1,613,000 1,417,000 1,405,000 1,196,000 952,000 871,000 868,000 792,000 788,000 787,000 764,000 760,000 747,000 745,000 714,000 633,000 612,000 539,000 324,000 256,000 235,000 4,699,000 3,849,000 3,832,000 3,821,000 3,472,000 3,237,000 3,106,000 2,904,000 2,831,000 2,717,000 2,717,000 2,714,000 2,712,000 2,704,000 2,703,000 2,691,000 2,684,000 2,389,000 2,386,000 2,097,000 2,091,000 2,090,000 1,154,000 1,151,000 1,120,000 1,111,000 1,023,000 1,008,000 938,000 892,000 693,000 692,000                               
        additional paid-in capital
      4,548,592,000 4,539,756,000 4,531,763,000 4,522,193,000 4,512,849,000 4,501,403,000 4,490,630,000 4,477,748,000 4,204,775,000 4,192,164,000 4,066,585,000 3,855,916,000 3,767,733,000 3,737,979,000 3,640,597,000 3,604,614,000 3,566,292,000 3,351,967,000 3,310,513,000 3,237,085,000 3,180,114,000 2,535,476,000 1,848,644,000 1,699,072,000 1,450,279,000 1,260,551,000 1,226,314,000 1,210,941,000 1,201,853,000 1,140,964,000 1,132,738,000 1,127,298,000 1,069,391,000 1,020,457,000 997,014,000 968,996,000 956,299,000 935,997,000 932,208,000 925,629,000 920,001,000 951,569,000 947,055,000 934,176,000 926,691,000 727,369,000 724,908,000 615,279,000 612,900,000 611,913,000 380,931,000 380,970,000 373,277,000 374,384,000 354,776,000 350,957,000 329,646,000 315,037,000 285,248,000 284,595,000 284,158,000 265,901,000 265,103,000 264,618,000 264,219,000 263,629,000 262,289,000 261,822,000 260,816,000 260,400,000 259,713,000 195,361,000 171,403,000 167,511,000 167,496,000 167,496,000 167,468,000 144,655,000 144,351,000 144,288,000 120,457,000 120,389,000 118,938,000 102,361,000 102,217,000 102,217,000 100,209,000  97,086,000  
        accumulated deficit
      -4,577,639,000 -4,568,148,000 -4,585,675,000 -4,383,296,000 -4,489,804,000 -5,008,450,000 -4,927,420,000 -4,806,120,000 -4,968,501,000 -4,820,951,000 -4,642,562,000 -4,511,786,000 -4,569,794,000 -4,275,889,000 -4,093,640,000 -3,925,027,000 -3,414,542,000 -3,617,950,000 -2,771,666,000 -2,449,235,000 -2,096,918,000 -1,874,199,000 -1,696,635,000 -1,499,325,000 -1,457,665,000 -1,431,801,000 -1,399,971,000 -1,381,928,000 -1,342,325,000 -1,299,107,000 -1,249,773,000 -1,205,203,000 -1,160,711,000 -1,114,359,000 -1,063,517,000 -1,018,909,000 -974,444,000 -929,996,000 -872,887,000 -806,633,000 -727,282,000 -650,030,000 -571,224,000 -538,104,000 -517,463,000 -461,547,000 -441,820,000 -423,956,000 -410,146,000 -396,092,000 -325,951,000 -322,738,000 -317,745,000 -305,344,000 -294,988,000 -285,562,000 -260,195,000 -252,665,000 -244,125,000 -235,776,000 -224,696,000 -216,854,000 -207,482,000 -199,727,000 -190,510,000 -181,544,000 -173,350,000 -164,962,000 -158,814,000 -153,800,000 -147,389,000 -141,894,000 -148,049,000 -145,322,000 -139,606,000 -130,720,000 -120,431,000 -117,775,000 -110,058,000 -104,800,000 -101,717,000 -98,357,000 -93,328,000 -87,527,000 -82,382,000 -75,668,000 -70,172,000  -61,637,000  
        treasury stock
      -112,319,000 -103,021,000 -102,663,000 -102,459,000 -101,938,000 -95,854,000 -94,860,000 -94,439,000 -93,950,000 -92,267,000 -91,706,000 -91,424,000 -91,226,000 -90,659,000 -89,940,000 -86,455,000 -85,901,000 -85,101,000 -79,132,000 -47,205,000 -44,457,000 -41,806,000 -41,207,000 -2,638,000 -2,638,000 -2,583,000 -2,583,000 -2,451,000 -2,450,000 -2,450,000 -2,450,000 -2,450,000 -2,450,000 -2,450,000 -2,450,000 -2,450,000 -2,450,000 -2,450,000 -2,450,000 -2,450,000 -2,450,000 -2,450,000 -2,450,000 -2,450,000 -2,450,000 -2,450,000 -2,450,000 -2,450,000 -2,450,000 -2,450,000 -2,450,000 -2,450,000 -2,450,000 -2,450,000 -2,450,000 -2,450,000 -2,450,000 -2,450,000 -2,450,000 -2,450,000 -2,450,000 -2,450,000 -2,450,000 -2,450,000 -2,450,000 -2,450,000 -2,450,000 -2,450,000 -2,449,000 -2,356,000 -2,356,000 -2,413,000 -2,413,000 -2,413,000 -2,413,000 -2,413,000 -2,413,000 -2,413,000 -2,413,000 -2,413,000           
        accumulated other comprehensive income
      -5,074,000 2,010,000  -458,000 1,608,000 -22,559,000 3,598,000 -10,508,000 -10,825,000 2,722,000        -1,353,000 861,000 4,170,000 -357,000 7,024,000                        -4,111,000 -1,293,000 90,000 839,000 1,113,000 913,000 910,000 899,000 864,000 734,000 758,000 650,000 479,000                                 
        total stockholders’ deficit
      -144,762,000 -127,753,000 -156,672,000  -75,643,000 -623,841,000 -526,436,000 -431,706,000 -867,084,000 -716,927,000 -678,350,000 -754,519,000 -895,582,000  -565,985,000 -416,950,000         -23,971,000 -186,017,000 -189,838,000 -185,493,000 -150,583,000 -167,935,000 -126,679,000 -87,707,000 -99,369,000 -101,732,000 -74,151,000 -59,062,000 -29,099,000                                                      
        total liabilities and stockholders’ deficit
      1,043,162,000 1,176,512,000 1,179,889,000  1,292,992,000 1,560,418,000 1,712,483,000 1,818,646,000 1,353,534,000 1,797,490,000 1,657,157,000 1,685,048,000 1,542,699,000  2,267,437,000 2,622,993,000         328,068,000 172,957,000 164,810,000 189,389,000 221,319,000 207,978,000 250,478,000 285,807,000 276,067,000 302,493,000 334,077,000 355,706,000 361,504,000                                                      
        convertible notes payable
       244,213,000 243,835,000 170,568,000 170,126,000 169,684,000 169,265,000 168,848,000 168,432,000     324,881,000 324,525,000 324,169,000 323,814,000 323,458,000 323,102,000 322,746,000 322,390,000 322,035,000 321,679,000 321,323,000 320,967,000 320,611,000 320,255,000 319,899,000 319,543,000 319,187,000 318,830,000 318,475,000 318,119,000 317,763,000 317,407,000 317,051,000 316,695,000 316,339,000 315,983,000 315,627,000 315,271,000                                                  
        stockholders’ deficit:
                                                                                                
        right of use asset
        23,873,000 153,044,000 157,495,000 161,585,000 165,766,000 169,507,000 181,175,000 185,218,000 190,741,000 95,739,000 103,923,000 106,241,000 108,543,000 85,770,000 86,352,000                                                                          
        accumulated other comprehensive loss
        -1,745,000        -11,863,000 -8,177,000 -3,166,000 -6,377,000 -23,794,000 -10,870,000 -1,312,000      -4,995,000 -13,195,000 -14,486,000 -12,508,000 -13,854,000 -12,290,000 -12,360,000 -11,191,000 -11,026,000 -11,173,000 -9,071,000 -8,617,000 -8,304,000 -9,603,000 -11,335,000 -11,814,000 -9,804,000 -9,143,000 -7,548,000 -9,124,000 -9,068,000 -8,710,000 -9,756,000                                              
        liabilities and stockholders’ equity
                                                                                                
        stockholders' equity
                                                                                                
        total stockholders’ equity
         37,625,000          -634,078,000   65,324,000 -351,673,000 461,336,000 745,562,000 1,039,127,000 627,209,000 106,440,000               -5,546,000 49,784,000 110,117,000 185,433,000 292,669,000 367,016,000 387,603,000 399,706,000 261,650,000 281,731,000 191,060,000 203,234,000 216,574,000 54,597,000 56,271,000 53,529,000 66,993,000 57,523,000 63,139,000 67,017,000 59,721,000 37,794,000 45,489,000 56,132,000 47,221,000 55,795,000 63,065,000 71,883,000 80,259,000 87,112,000 94,001,000 99,139,000 103,830,000 109,105,000 49,652,000 19,902,000 18,694,000 24,395,000 33,281,000 43,542,000 23,338,000 30,750,000 35,944,000       23,029,000  29,997,000  
        total liabilities and stockholders’ equity
         1,336,549,000          2,258,679,000   2,834,875,000 2,576,753,000 2,565,941,000 2,749,587,000 2,608,366,000 1,582,479,000 944,020,000               394,301,000 459,626,000 525,004,000 592,507,000 386,038,000 404,634,000 424,698,000 438,841,000 292,514,000 311,991,000 218,599,000 235,937,000 245,074,000 67,085,000 69,346,000 70,136,000 79,314,000 68,945,000 75,377,000 75,880,000 73,221,000 67,962,000 76,625,000 89,519,000 80,777,000 86,221,000 91,291,000 99,706,000 108,039,000 115,390,000 121,877,000 125,381,000 130,576,000 135,432,000 84,382,000 60,546,000 60,298,000 66,578,000 77,993,000 87,600,000 74,617,000 78,800,000 84,159,000       62,890,000  68,830,000  
        stockholders’ equity
                                                                                                
        intangible assets
                    8,456,000 4,033,000 4,535,000 4,770,000 5,027,000 5,281,000 5,270,000 5,725,000 5,332,000 5,250,000 5,052,000 5,581,000 5,469,000 5,958,000 6,114,000 6,541,000 6,754,000 6,897,000 7,575,000 7,873,000 8,138,000 9,475,000 9,161,000 9,225,000 9,958,000 10,300,000 10,962,000 10,793,000 11,005,000 11,360,000 11,198,000 13,763,000 15,090,000 15,918,000 16,250,000                   978,000                       
        unbilled receivable
                        34,678,000                                                                        
        stockholders' equity:
                                                                                                
        unbilled services
                         21,374,000 45,295,000  3,826,000                                                                    
        accrued interest
                           5,078,000 2,031,000 5,078,000 2,031,000 5,078,000 2,031,000 5,078,000 2,031,000 5,078,000 2,031,000 5,078,000 2,031,000 5,078,000 2,031,000 5,078,000 2,031,000 5,078,000 2,031,000 5,146,000 2,099,000                                                  
        liabilities, preferred stock and stockholders’ equity
                                                                                                
        total stockholders' equity
                             184,526,000                                                                   
        total liabilities, preferred stock and stockholders' equity
                             932,227,000                                                                   
        revenue:
                                                                                                
        grant and other
                              3,377,000  2,507,000 3,357,000 3,982,000                                                              
        total revenue
                              3,377,000  2,507,000 3,357,000 3,982,000      8,352,000 6,732,000   3,231,000 2,505,000                                                   
        expenses:
                                                                                                
        research and development
                              16,895,000  18,611,000 30,417,000 35,473,000      41,862,000 39,263,000   52,983,000 64,904,000                                                   
        general and administrative
                              9,379,000  7,899,000 9,606,000 8,732,000      8,118,000 8,940,000   13,556,000 14,099,000                                                   
        total expenses
                              26,274,000  17,494,000 40,023,000 44,205,000      49,980,000 48,203,000   66,539,000 79,003,000                                                   
        income from operations
                              -22,897,000  -14,987,000 -36,666,000 -40,223,000      -41,628,000 -41,471,000   -63,308,000 -76,498,000                                                   
        other income:
                                                                                                
        investment income
                              436,000  342,000 474,000 420,000      531,000 523,000   554,000 670,000                                                   
        interest expense
                              -3,403,000  -3,403,000 -3,403,000 -3,403,000      -3,520,000 -3,516,000   -3,511,000 -3,512,000                                                   
        other income
                                5,000 -8,000 -12,000      10,000 -1,000   11,000 -11,000                                                   
        net income
                              -25,864,000  -18,043,000 -39,603,000 -43,218,000      -44,607,000 -44,465,000   -66,254,000 -79,351,000                                                   
        basic and diluted net income per share
                              -580  -740 -1,690 -110      -150 -160   -240 -290                                                   
        basic and diluted weighted-average number of common shares outstanding
                              44,421,000  24,327,000 23,473,000 408,843,000      296,435,000 283,444,000   271,064,000 270,760,000                                                   
        f-4
                                                                                                
        gain on catalent transaction
                                -9,016,000                                                                
        1
                                                                                                
        government contracts
                                            102,000 134,000                                                   
        research and development collaborations
                                        8,352,000 6,732,000   3,129,000 2,371,000                                                   
        notes payable
                                            45,000 149,000 252,000                                                  
        deferred rent
                                            1,067,000 1,190,000 1,337,000 1,409,000 1,212,000 1,187,000 1,161,000 1,061,000 1,042,000 475,000 470,000 466,000 375,000 364,000 352,000 330,000 319,000 292,000 278,000 273,000 334,000 328,000 324,000 652,000 390,000 391,000 389,000 360,000 208,000 79,000 112,000 144,000 160,000 176,000 190,000 165,000 166,000 166,000 166,000 171,000 162,000 154,000           
        stockholders’ equity:
                                                                                                
        commitments and contingences
                                                                                                
        accounts receivable – billed
                                               1,449,000 2,197,000 2,342,000 6,674,000 2,859,000 3,719,000                                            
        accounts receivable – unbilled
                                               871,000                                                 
        current portion of notes payable
                                               395,000 493,000 532,000 579,000 795,000 822,000 852,000 877,000 597,000 40,000 60,000 80,000 80,000 80,000 80,000 281,000 234,000 385,000 650,000 182,000 333,000 482,000 1,120,000 305,000 476,000 508,000 731,000 219,000 386,000 552,000 715,000                   
        non-current portion of notes payable
                                                45,000 149,000 252,000 571,000 717,000 861,000 1,004,000 1,653,000 300,000 300,000 300,000 340,000 360,000 380,000  450,000 468,000 480,000 200,000 220,000 240,000 260,000 550,000 627,000 396,000 458,000 514,000 569,000 624,000 678,000                   
        account receivable – unbilled
                                                2,137,000 2,498,000 4,196,000 4,233,000 4,839,000                                            
        short-term investments available-for-sale
                                                   143,617,000 48,599,000 2,907,000 13,597,000 23,917,000 5,286,000 9,229,000 15,565,000 20,648,000 17,340,000 18,313,000                                   
        prepaid expenses
                                                   6,395,000 5,116,000 4,626,000 3,044,000 3,016,000 2,392,000                                        
        other current assets
                                                   402,000 269,000 504,000 573,000 365,000 392,000                                        
        investments available-for-sale
                                                   12,189,000 56,352,000                                            
        accrued expenses and other current liabilities
                                                   13,712,000 10,998,000 8,208,000 11,223,000 9,553,000 3,931,000 3,110,000 4,832,000 5,761,000 4,637,000 3,326,000 3,544,000 3,229,000 3,208,000 2,969,000    2,980,000    3,078,000                       
        current portion of capital leases
                                                   89,000 97,000 105,000 108,000 115,000                                         
        non-current portion of capital leases
                                                   150,000 172,000 191,000 195,000 222,000                                         
        unbilled receivables
                                                     6,113,000 4,988,000 3,194,000 3,848,000 2,020,000 834,000                                      
        accounts receivables
                                                      1,911,000 1,911,000 17,000 1,832,000 2,517,000                                      
        warrant liability
                                                        869,000 1,605,000 2,909,000                                      
        intangibles
                                                       16,405,000                                         
        notes receivable from former directors
                                                         -1,572,000 -1,572,000 -1,572,000 -1,572,000 -1,572,000                                   
        accounts and other receivables
                                                           599,000 356,000 231,000                                   
        short-term investments classified as available for sale
                                                              4,391,000 5,978,000 5,958,000  8,450,000 8,875,000 14,625,000 9,200,000                           
        accounts and other receivables, net of allowance for doubtful accounts of 218 as of september 30, 2009 and december 31, 2008, respectively
                                                              173,000                                  
        current assets of discontinued operations
                                                                 132,000 523,000 711,000 414,000 531,000                           
        convertible notes, current
                                                               4,996,000 21,881,000  21,676,000                              
        current liabilities of discontinued operations
                                                                 242,000 75,000 3,625,000 2,839,000 616,000                           
        non-current liabilities
                                                              433,000                                  
        notes receivable from directors
                                                              -1,572,000 -1,572,000 -1,572,000 -1,572,000 -1,572,000       -1,031,000 -1,032,000 -1,032,000 -1,480,000 -1,480,000 -1,480,000 -1,480,000 -1,480,000 -1,480,000 -1,480,000 -1,480,000 -1,480,000 -1,480,000 -1,480,000 -1,480,000 -1,480,000 -1,480,000       
        accounts and other receivables, net of allowance for doubtful accounts of 218 as of june 30, 2009 and december 31, 2008, respectively
                                                               41,000                                 
        accounts and other receivables, net of allowance for doubtful accounts of 218 as of march 31, 2009 and december 31, 2008
                                                                61,000                                
        short-term investments available for sale
                                                                 6,962,000                               
        short-term investments held to maturity
                                                                                                
        accounts and other receivables, net of allowance for doubtful accounts of 218 and 168 as of december 31, 2008 and 2007, respectively
                                                                 290,000                               
        non-current assets of discontinued operations
                                                                  258,000 280,000 500,000 1,634,000                           
        convertible notes, current portion net of discount
                                                                 21,778,000                               
        convertible notes, net of discount
                                                                     21,369,000 21,267,000                          
        short-term investments classified as held to maturity
                                                                   3,497,000 11,566,000 32,939,000                           
        accounts and other receivables, net of allowance for doubtful accounts of 209 and 168 as of september 30, 2008 and december 31, 2007, respectively
                                                                  330,000                              
        accrued expenses and other liabilities
                                                                  5,961,000                              
        convertible notes, non-current
                                                                                                
        preferred stock, .01 par value...
                                                                                                
        common stock, .01 par value...
                                                                  692,000 624,000 624,000 624,000 624,000 624,000 623,000 622,000 618,000 618,000 617,000 503,000 441,000 398,000 398,000 398,000 398,000 351,000 350,000 349,000           
        accounts and other receivables, net of allowance for doubtful accounts of 211 and 168 as of june 30, 2008 and december 31, 2007, respectively
                                                                   327,000                             
        convertible notes
                                                                   21,574,000 21,471,000   21,148,000 22,000,000 22,000,000 22,000,000 22,000,000 22,000,000 29,000,000 35,000,000 35,000,000 35,000,000 35,000,000 35,000,000 40,000,000 40,000,000 40,000,000 40,000,000 40,000,000 40,000,000 40,000,000 40,000,000 40,000,000   30,000,000  
        accounts and other receivables, net of allowance for doubtful accounts of 207 and 168 as of march 31, 2008 and december 31, 2007, respectively.
                                                                    647,000                            
        bank overdraft
                                                                    579,000  483,000 174,000 790,000                        
        accounts and other receivables, net of allowance for doubtful accounts of 168 and 117 as of december 31, 2007 and 2006, respectively
                                                                     667,000                           
        other intangible assets
                                                                      879,000 912,000 945,000  1,011,000 1,044,000 1,077,000 1,110,000 3,330,000 4,617,000 4,832,000 5,048,000 5,467,000 2,983,000 3,146,000 3,310,000 3,474,000 3,637,000 3,803,000 3,966,000       
        note receivable from director
                                                                                                
        short-term investments
                                                                      36,444,000 53,879,000 59,847,000 66,434,000 53,851,000                      
        accounts and other receivables, net of allowance for doubtful accounts of 186 and 117 as of september 30, 2007 and december 31, 2006, respectively
                                                                      1,601,000                          
        accounts and other receivables, net of allowance for doubtful accounts of 236 and 117 as of june 30, 2007 and december 31, 2006, respectively
                                                                       787,000                         
        accounts and other receivables, net of allowance for doubtful accounts of 185 and 117 as of march 31, 2007 and december 31, 2006, respectively.
                                                                        906,000                        
        accounts and other receivables, net of allowance for doubtful accounts of 117 and 429 at december 31, 2006 and 2005
                                                                         1,274,000                       
        facility exit costs
                                                                          13,000 54,000 96,000                    
        unearned compensation
                                                                             -425,000                   
        accounts and other receivables, net of allowance for doubtful accounts of 346 and 429 as of september 30, 2006 and december 31, 2005, respectively
                                                                          3,125,000                      
        accounts and other receivables, net of allowance for doubtful accounts of 325 and 429 as of june 30, 2006 and december 31, 2005, respectively
                                                                           3,825,000                     
        accounts and other receivables, net of allowance for doubtful accounts of 288 and 429 as of march 31, 2006 and december 31, 2005, respectively
                                                                            3,601,000                    
        other non current assets
                                                                            661,000  1,255,000 1,477,000 1,585,000  1,964,000 799,000 546,000            
        accounts and other receivables, net of allowance for doubtful accounts of 429 and 752 as of december 31, 2005 and 2004
                                                                             3,571,000                   
        current portion of facility exit costs
                                                                             138,000                   
        non-current portion of facility exit costs
                                                                                                
        trade accounts receivable, net of allowance for doubtful accounts of 387 and 752 as of september 30, 2005 and december 31, 2004, respectively
                                                                              1,147,000                  
        current portion of capital lease obligations and other liabilities
                                                                              467,000 654,000 932,000 1,194,000               
        non-current portion of capital lease obligations and other liabilities
                                                                              746,000 808,000 887,000 970,000 1,047,000              
        trade accounts receivable, net of allowance for doubtful accounts of 765 and 752 as of june 30, 2005 and december 31, 2004, respectively
                                                                               1,133,000                 
        trade accounts receivable, net of allowance for doubtful accounts of 773 and 752 as of march 31, 2005 and december 31, 2004, respectively
                                                                                626,000                
        trade accounts receivable, net allowance for doubtful accounts of 752 and 376 for the years ended december 31, 2004 and 2003
                                                                                 827,000               
        deferred revenue – current
                                                                                   250,000 250,000 250,000   250,000  350,000 425,000   2,000,000  
        deferred revenue – non-current
                                                                                   2,000,000 2,062,000 2,125,000   2,313,000    2,563,000    
        trade accounts receivable, net of allowance for doubtful accounts of 551 and 376 as of september 30, 2004 and december 31, 2003, respectively
                                                                                  1,780,000              
        deferred revenue — current
                                                                                      250,000 250,000  275,000   500,000    
        current portion of capital lease obligations and other liabilities.
                                                                                  357,000              
        deferred revenue — non-current
                                                                                      2,187,000 2,250,000  2,375,000       
        trade accounts receivable, net of allowance for doubtful accounts of 397 and 376 as of june 30, 2004 and december 31, 2003
                                                                                   3,299,000             
        current portion of long term debt and capital lease obligations
                                                                                   435,000 782,000 1,065,000   169,000 211,000       
        non-current portion of long term debt and capital lease obligations
                                                                                   997,000 1,049,000            
        cash and cash equivalent
                                                                                    21,885,000            
        trade accounts receivable, net of allowance for doubtful accounts of 382 and 376 as of march 31, 2004 and december 31, 2003
                                                                                    2,318,000            
        trade accounts receivable, net allowance for doubtful accounts of 376 and 193 for the years ended december 31, 2003 and 2002
                                                                                     1,960,000           
        other long term assets
                                                                                     402,000   476,000 501,000       
        non current portion of long term debt and capital lease obligations
                                                                                     1,100,000           
        other long-term assets
                                                                                      426,000 453,000         
        current portion of capital lease obligations
                                                                                      226,000          
        long-term debt, capital lease obligations and other
                                                                                      1,296,000 1,345,000         
        current portion of long-term debt and capital lease obligations
                                                                                       226,000         
        trade accounts receivable
                                                                                        1,271,000 1,882,000       
        long terms debt, capital lease obligations and other
                                                                                        1,434,000        
        long term debt, capital lease obligations and other
                                                                                         1,193,000       
        goodwill and other intangible assets
                                                                                          37,271,000 37,435,000 37,599,000  38,546,000  
        deferred revenue – non current
                                                                                          2,437,000 2,500,000     
        notes receivable from shareholders
                                                                                          -1,519,000 -1,480,000 -1,480,000    
        assets current assets:
                                                                                                
        liabilities and stockholders’ equity current liabilities:
                                                                                                
        convertible note
                                                                                            30,000,000    
        3.1
                                                                                                
        3.2
                                                                                                
        4.
                                                                                                
        ††10.1
                                                                                             1,995   
        ††10.2
                                                                                               1,995 
        ††10.3
                                                                                                
        ††10.4
                                                                                                
        ††10.5
                                                                                                
        ††10.6
                                                                                                
        *††10.7
                                                                                                
        *††10.8
                                                                                                
        10.9
                                                                                                
        *10.10
                                                                                                
        *10.11
                                                                                                
        *10.12
                                                                                                
        *10.13
                                                                                                
        10.14
                                                                                                
        10.15
                                                                                                
        10.16
                                                                                                
        10.17
                                                                                                
        10.18
                                                                                                
        10.19
                                                                                                
        10.20
                                                                                                
        10.21
                                                                                                
        10.22
                                                                                                
        10.23
                                                                                                
        10.24
                                                                                                
        3.3
                                                                                                
        *3.4
                                                                                                
        10.1
                                                                                                
        *††10.4
                                                                                                
        10.6
                                                                                                
        ††10.7
                                                                                                
        ††10.8
                                                                                                
        10.11
                                                                                                
        10.12
                                                                                                
        10.13
                                                                                                
        16.
                                                                                                
        *21
                                                                                                
        *23.1
                                                                                                
        *23.2
                                                                                                
        27
                                                                                                
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-09-30 2012-06-30 2012-03-31 2011-09-30 2011-06-30 2011-03-31 2010-09-30 2010-06-30 2010-03-31 2009-09-30 2009-06-30 2009-03-31 2008-12-31 2008-09-30 2008-06-30 2008-03-31 2007-12-31 2007-09-30 2007-06-30 2007-03-31 2006-12-31 2006-09-30 2006-06-30 2006-03-31 2005-12-31 2005-09-30 2005-06-30 2005-03-31 2004-12-31 2004-09-30 2004-06-30 2004-03-31 2003-12-31 2003-09-30 2003-06-30 2003-03-31 2002-12-31 2002-09-30 2002-06-30 2002-03-31 
                                                                                                    
          operating activities:
                                                                                                    
          net income
        -9,491,000 17,527,000 -202,379,000 106,508,000 518,646,000        -293,905,000    203,408,000                           -20,641,000 -24,370,000   -13,810,000 -14,054,000 -15,299,000 -12,634,000 -9,996,000 -7,216,000 -5,920,000 -7,336,000       -7,530,000 -8,540,000 -8,349,000        -8,388,000 -6,148,000 -5,014,000 -6,411,000 -5,495,000 6,155,000    -10,289,000 -2,656,000 -7,717,000 -5,258,000 -3,083,000 -3,360,000 -5,028,000 -5,802,000 -5,145,000    
          reconciliation of net income to net cash from operating activities:
                                                                                                    
          depreciation and amortization
        3,062,000 5,125,000 6,585,000 7,563,000 8,340,000 12,517,000 12,700,000 11,132,000 12,147,000 10,794,000 11,321,000 10,067,000 9,043,000 7,222,000 8,347,000 6,720,000 6,765,000 3,672,000 4,262,000 2,410,000 2,317,000 1,794,000 1,186,000 980,000 925,000 932,000 880,000 1,925,000 1,939,000 1,982,000 2,041,000 2,057,000 2,079,000 2,121,000 3,529,000 2,056,000 2,111,000 2,218,000 2,221,000 2,112,000 1,954,000 1,636,000 1,552,000 1,486,000 1,309,000 1,039,000 976,000 980,000 955,000 675,000 512,000 449,000 406,000 406,000 404,000 409,000 399,000 389,000 358,000 337,000 296,000                                
          non-cash stock-based compensation
        7,724,000  8,549,000 9,214,000 10,285,000 10,448,000 12,049,000 14,099,000 11,556,000 15,658,000 20,760,000 20,292,000 28,647,000 27,775,000 31,544,000 38,048,000 32,933,000 32,169,000 45,274,000 53,123,000 53,060,000 50,433,000 65,705,000 7,932,000 3,965,000 4,245,000 2,624,000 4,621,000 5,558,000 4,387,000 4,431,000 4,251,000 5,245,000 6,752,000 4,331,000 4,513,000 4,213,000 3,780,000 5,162,000 5,257,000 4,961,000 4,153,000 4,764,000 2,582,000 1,932,000 1,691,000 1,852,000 1,040,000 696,000 663,000 638,000 483,000 492,000 589,000 587,000 542,000 703,000 432,000 632,000 425,000 84,000                                
          provision for excess and obsolete inventory
         566,000 1,103,000 276,000 1,057,000 1,441,000 9,665,000 8,807,000 22,664,000 17,987,000 19,056,000 12,490,000 89,522,000 202,413,000                                                                              
          impairment of long-lived assets
        266,000  3,033,000   -1,299,000 3,762,000 1,669,000                                                                                  
          other items
        -8,972,000 1,303,000 -229,000 -11,868,000 16,550,000 -18,023,000 -1,099,000 1,762,000 -4,449,000 -4,027,000 -2,926,000 1,163,000 -1,252,000 3,156,000 -24,417,000 -1,276,000 634,000 -10,380,000                                                                           
          changes in operating assets and liabilities:
                                                                                                    
          inventory
        -226,000 2,148,000 -3,753,000 -4,010,000 2,375,000 -189,000 -1,073,000 -2,643,000 16,819,000 8,085,000 -63,181,000 -10,139,000 -9,222,000 -51,335,000 -22,741,000 -304,168,000 -99,557,000                                               -2,000  -8,000 -4,000 -18,000  -54,000 291,000 -135,000 300,000 -143,000 23,000 20,000  -538,000 971,000 1,092,000  -1,531,000 125,000 -17,000 -124,000        
          accounts receivable, prepaid expenses, and other assets
        86,243,000 -51,940,000 207,927,000 -168,814,000 73,867,000 913,000 -37,590,000 94,712,000 296,054,000 -240,024,000 232,064,000 -284,912,000 18,430,000 77,841,000 58,480,000                                                                              
          accounts payable, accrued expenses, and other liabilities
        -60,078,000 -21,543,000 -26,535,000 -62,642,000 -211,846,000 -42,468,000 23,326,000 -94,023,000 -272,461,000 -29,544,000 93,977,000 -213,139,000 -230,099,000 822,981,000 -88,740,000                                                                              
          deferred revenue
        -50,951,000 -2,367,000 -11,712,000 -4,865,000 -603,995,000 -6,902,000 -37,030,000 117,184,000 -6,147,000 211,889,000 -218,881,000 217,585,000 140,275,000 -890,646,000 -78,459,000 -15,418,000 -61,391,000 332,967,000 45,745,000 397,261,000 549,584,000 191,410,000 -77,038,000 155,736,000 1,437,000 -915,000 -1,839,000 -2,410,000 -3,167,000 -5,354,000 7,682,000 -8,691,000 -9,247,000 -9,447,000 -7,931,000 18,321,000 -5,399,000 -77,000 -2,649,000 -1,687,000 -1,644,000 36,035,000 -4,000 2,000 107,000 -17,000 -28,000 -215,000 -142,000 59,000 -78,000 -180,000      -47,000 -7,000 -89,000                     -62,000 -63,000 -62,000        
          net cash from operating activities
        -32,423,000 -39,475,000 107,804,000 -127,462,000 -185,502,000 -173,163,000 -144,814,000 314,269,000 -83,555,000 -176,781,000 -39,655,000 -171,938,000 -325,593,000 -117,816,000 -38,708,000 -170,903,000 -88,510,000 -342,408,000 -142,143,000 144,412,000 663,085,000 -128,568,000 -6,497,000 115,634,000 -23,110,000  -32,259,000 -30,014,000 -50,607,000 -45,266,000 -33,513,000 -39,971,000 -66,075,000 -32,078,000 -37,255,000 -30,746,000 -38,617,000 -61,248,000 -62,356,000 -62,032,000 -69,831,000 -54,751,000 -28,527,000 -12,322,000 -30,490,000 -15,874,000 -10,941,000 -20,431,000 -12,263,000 -14,880,000 -7,633,000 -10,583,000 -3,793,000 -6,126,000 -4,220,000 -3,321,000 -8,398,000 -9,041,000 -8,317,000 -9,347,000 -9,380,000 -6,417,000 -7,300,000 -6,727,000  -10,418,000 -1,970,000 -5,202,000  -9,159,000 -5,952,000 -6,697,000  -3,239,000 -4,829,000 -4,328,000  -789,000 -4,379,000 -8,359,000  -9,960,000 -5,853,000 -4,891,000      -5,888,000   
          investing activities:
                                                                                                    
          capital expenditures, including internal-use software
        -1,270,000                                                                                            
          proceeds from assets held for sale
        39,750,000                                                                                            
          purchases of marketable securities
        -214,130,000                 -2,167,000 -96,872,000 -158,722,000 -50,002,000 -57,606,000 -15,000,000 -2,484,000 -2,978,000 -38,798,000 -76,390,000 -1,984,000 -50,976,000 -16,025,000 -40,714,000 -110,330,000 -28,806,000 -37,120,000 -44,050,000 -246,580,000 -74,233,000 -78,559,000 -68,931,000 -6,798,000                                                
          proceeds from maturities of marketable securities
        147,289,000                     109,074,000 66,738,000   15,000,000 2,500,000 22,000,000 51,813,000 47,190,000 28,394,000 22,721,000 68,385,000 59,208,000 44,479,000 86,130,000  133,654,000 68,560,000 82,657,000  73,757,000 33,900,000 29,450,000                                                
          net cash from investing activities
        -28,361,000   111,098,000 -73,319,000 144,007,000 31,912,000 -372,707,000 -7,250,000 -9,078,000 -18,391,000 -7,779,000 -23,558,000 -22,064,000 -29,519,000 -24,576,000 -16,826,000 -16,364,000 -12,190,000 -12,901,000 141,609,000 -31,122,000 -100,710,000 -188,218,000 -57,728,000  17,973,000 2,024,000 18,711,000 48,318,000 7,996,000 -48,305,000 20,587,000   2,531,000 -25,284,000 85,905,000 92,571,000 18,981,000 -169,440,000 9,559,000 -9,210,000 -39,407,000 17,788,000 -54,100,000 -102,781,000 9,701,000 9,161,000 15,412,000 -3,207,000 -4,974,000 -7,349,000 -4,528,000 -3,270,000    -3,958,000 829,000 -14,840,000 2,262,000 -104,000 68,000  6,187,000 11,428,000 15,598,000  17,577,000 6,319,000 6,729,000 -12,367,000 -53,793,000 -428,000 -227,000  -23,000 -72,000 -8,000  -525,000 -315,000 -587,000     -895,000 -2,401,000   
          financing activities:
                                                                                                    
          proceeds from credit facility, net of issuance costs
        46,411,000                                                                                            
          net proceeds from the exercise of stock-based awards, net of tax withholding
        -8,158,000                                                                                            
          finance lease payments
        -578,000 -6,274,000 -984,000 -612,000 -2,201,000 -2,756,000 -512,000 -366,000 -360,000 -2,319,000 1,758,000 -453,000 -26,331,000 -47,691,000 -29,993,000 4,927,000 -20,838,000 -64,031,000 -10,258,000 -41,647,000 -11,971,000 -30,641,000                                                                       
          net cash from financing activities
        37,675,000 -6,604,000 42,442,000 -1,040,000 -7,061,000 -3,422,000 -97,000 258,216,000 5,886,000 100,389,000 197,121,000 61,335,000 -354,379,000 191,440,000 -30,976,000 4,659,000 159,865,000 -60,711,000 -15,720,000 -38,843,000 576,987,000 404,610,000 -22,388,000 416,617,000 185,923,000  12,028,000 3,000 56,181,000 3,857,000 1,020,000 54,004,000 43,924,000 17,415,000 23,630,000 8,131,000 15,364,000 -54,000 480,000 253,000 278,351,000 201,000 8,522,000 4,064,000 195,496,000 581,000 107,698,000 1,170,000 92,000 119,371,000 4,391,000 7,181,000 6,546,000 12,115,000 7,259,000 923,000 7,002,000 1,353,000 19,044,000 3,389,000 38,000     17,512,000 -647,000 -44,000  61,000 -812,000 589,000 648,000     3,314,000 -309,000 -307,000   -94,000 -270,000 25,806,000 41,000   594,000 -8,000   
          effect of exchange rate on cash, cash equivalents, and restricted cash
        -18,000 -1,709,000 658,000 7,906,000 -930,000 -10,717,000 6,028,000 -156,000 -2,955,000 2,917,000 9,347,000 -620,000 -8,372,000 4,263,000 4,710,000 -5,765,000 1,312,000                                                                            
          net decrease in cash, cash equivalents, and restricted cash
        -23,127,000    -266,812,000    -87,874,000  148,422,000                                                                                  
          cash, cash equivalents, and restricted cash at beginning of period
        256,052,000  545,292,000  583,810,000  1,348,845,000  1,528,259,000                                                                            
          cash, cash equivalents, and restricted cash at end of period
        232,925,000  14,375,000 -9,498,000 278,480,000  -106,971,000 199,622,000 495,936,000  148,422,000 -119,002,000 636,943,000  -94,493,000 -196,585,000 1,584,100,000                                                                            
          supplemental disclosure of cash flow information:
                                                                                                    
          cash interest payments, net of amounts capitalized
        6,294,000 2,934,000 2,307,000 7,007,000 2,799,000 9,072,000 1,320,000 5,974,000 1,206,000 5,598,000 457,000 4,728,000 6,566,000                                                                                
          cash paid for income taxes, net of refunds received
        1,847,000                                                                                            
          reconciliation of net loss to net cash from operating activities:
                                                                                                    
          gain on disposition of novavax cz assets
                                                                                                    
          right-of-use assets expensed, net of credits received
                     -22,083,000 43,478,000                                                                              
          stock-based compensation
                                                                                                    
          impairment of assets held for sale
         807,000                                                                                           
          impairment of other long-lived assets
                                                                                                    
          loss on debt extinguishment
                                                                                                   
          capital expenditures
        -1,270,000 -2,076,000 -2,017,000 -247,000 -1,220,000 -1,932,000 -1,372,000 -2,875,000 -6,878,000 -8,839,000 -18,158,000 -6,973,000 -19,801,000 -24,576,000 -16,826,000 -16,364,000 -12,190,000 -15,151,000 -13,781,000 -42,012,000 -8,726,000 -3,762,000 -122,000  -360,000 -476,000 -805,000 -517,000 -396,000 -309,000 -150,000 -646,000 -1,225,000 -1,234,000 -1,084,000 -3,204,000 -3,963,000 -5,529,000 -5,517,000 -4,638,000 -4,408,000 -4,376,000 -4,864,000 -3,031,000 -957,000 -889,000 -1,023,000 -1,605,000 -1,615,000 -1,542,000 -1,126,000 -304,000 -772,000 -236,000 -137,000 -41,000 -712,000 -54,000 -658,000 -188,000 -105,000 -63,000  -778,000 -2,642,000 -1,631,000  -416,000 -318,000 -556,000  -473,000 -428,000 -227,000  -23,000 -72,000 -8,000  -525,000 -315,000 -587,000        
          free cash flows
        -33,693,000 -41,551,000 105,787,000 -127,709,000 -186,722,000 -175,095,000 -146,186,000 311,394,000 -90,433,000 -185,620,000 -57,813,000 -178,911,000 -345,394,000 -117,816,000 -38,708,000 -195,479,000 -105,336,000 -358,772,000 -154,333,000 129,261,000 649,304,000 -170,580,000 -15,223,000 111,872,000 -23,232,000  -32,619,000 -30,490,000 -51,412,000 -45,783,000 -33,909,000 -40,280,000 -66,225,000 -32,724,000 -38,480,000 -31,980,000 -39,701,000 -64,452,000 -66,319,000 -67,561,000 -75,348,000 -59,389,000 -32,935,000 -16,698,000 -35,354,000 -18,905,000 -11,898,000 -21,320,000 -13,286,000 -16,485,000 -9,248,000 -12,125,000 -4,919,000 -6,430,000 -4,992,000 -3,557,000 -8,535,000 -9,082,000 -9,029,000 -9,401,000 -10,038,000 -6,605,000 -7,405,000 -6,790,000  -11,196,000 -4,612,000 -6,833,000  -9,575,000 -6,270,000 -7,253,000  -3,712,000 -5,257,000 -4,555,000  -812,000 -4,451,000 -8,367,000  -10,485,000 -6,168,000 -5,478,000      -5,888,000   
          internal-use software
         -173,000 -280,000 -375,000 -320,000 -640,000 -250,000 -372,000 -239,000 -233,000 -806,000 -3,757,000                                                                                
          proceeds from disposition of novavax cz assets
                                                                                                    
          net proceeds from sales of common stock
             256,410,000 6,862,000 103,248,000 195,009,000   69,845,000 179,385,000 564,859,000 428,553,000 53,307,000 207,845,000 185,918,000 30,172,000 11,978,000 3,000 55,239,000 3,574,000 53,887,000 42,599,000 17,396,000 23,294,000 8,150,000 14,585,000      7,182,000 3,474,000 193,619,000             1,317,000      122,000           -41,000 56,022,000                 
          proceeds on the issuance of convertible senior notes due 2031, net of issuance costs
                                                                                                   
          payments of costs related to issuance of 2027 convertible notes
                 -3,591,000                                                                                
          proceeds from the exercise of stock-based awards, net of tax withholding
                                                                                                    
          repayment of 2023 convertible notes
                 -325,000,000                                                                                
          cash, cash equivalents, and restricted cash at beginning of year
                                                                                                    
          cash, cash equivalents, and restricted cash at end of year
                                                                                                    
          supplemental disclosure of non-cash activities:
                                                                                                    
          issuance of convertible senior notes due 2031 in exchange for convertible senior notes due 2027
                                                                                                   
          sale of common stock under the sales agreement not settled at year-end
                                                                                                    
          capital expenditures included in accounts payable and accrued expenses
          169,000   -544,000 -530,000 929,000 1,208,000 5,505,000 -4,197,000 -4,256,000 10,847,000 5,681,000 -5,906,000 2,016,000 15,874,000 2,454,000 -3,153,000 1,961,000 9,076,000 3,066,000                                                                       
          right-of-use assets from new lease agreements, net of tenant improvement allowance on facility leases
                                                                                                    
          purchases of available-for-sale marketable securities
          -235,012,000 -114,724,000  -71,683,000                                                                                      
          proceeds from maturities of available-for-sale marketable securities
          100,500,000 111,625,000 43,000,000                                                                                        
          net cash provided used in investing activities
                                                                                                    
          net proceeds from the exercise of stock-based awards
          820,000 -428,000 -4,860,000 -666,000 415,000 2,172,000 -616,000 -540,000 354,000 -198,000 543,000 -706,000 -983,000 -268,000 1,318,000 3,320,000 -5,462,000                                                                          
          net increase in cash, cash equivalents, and restricted cash
          14,375,000    -106,971,000      -711,902,000 55,823,000 -94,493,000 -196,585,000 55,841,000                                                                            
          right-of-use assets from new lease agreements
                 6,807,000    -26,407,000 48,896,000 11,014,000 58,352,000 144,296,000 6,088,000 19,056,000 9,770,000 59,237,000                                                                       
          internal-use software included in accounts payable and accrued expenses
                250,000                                                                                    
          cash paid for income taxes, net of refunds
          3,878,000 3,423,000 1,499,000  1,290,000 -578,000 -71,000                                                                                    
          right-of-use asset leases, net of tenant improvement allowance on facility leases
              3,987,000                                                                                      
          net loss
             -81,030,000   -147,550,000 -178,389,000 -130,776,000   -182,249,000 -168,613,000   -846,284,000 -322,431,000 -352,317,000 -222,719,000 -177,564,000 -197,310,000 -17,521,000 -25,864,000 -31,830,000 -18,043,000 -39,603,000 -43,218,000 -49,334,000 -44,570,000 -44,492,000 -46,352,000 -50,842,000 -44,608,000 -44,465,000 -43,854,000 -57,109,000 -66,254,000 -79,351,000 -77,252,000 -78,806,000    -19,727,000                                 -5,716,000 -8,886,000           -5,496,000 -5,342,000 
          proceeds from issuance of 2027 convertible notes
                                                                                                    
          sale of common stock under the sales agreement not settled at quarter-end
                                          258,000 109,000 225,000                                                        
          cash paid for income taxes
                 62,000   137,000 65,000 2,327,000 15,451,000 6,565,000 3,024,000 3,017,000                                                                        
          sales of common stock not settled at end of period
                                                                                                    
          acquisition of novavax cz, net of cash acquired
                             -1,312,000                                                                       
          net proceeds from sale of preferred stock
                                                                                                  
          proceeds from issuance of convertible notes
                                             325,000,000                                                    
          payments of costs related to issuance of convertible notes
                                             -9,966,000                                                    
          purchases of property and equipment
                                                                                                    
          internal-use software development costs
                                                                                                    
          proceeds from maturities and sale of marketable securities
                          2,250,000 157,557,000                                                                        
          cash interest payments
                      8,656,000 1,950,000 6,654,000  7,722,000 2,516,000 7,530,000                                         118,000 238,000 523,000  411,000 -34,000 688,000  -531,394,000    529,000                   
          right-of-use assets expensed
                        214,000    951,000                                                                        
          receivables, prepaid expenses, and other assets
                        -56,016,000                                                                            
          accounts payable and accrued expenses
                        -115,500,000 419,618,000 65,496,000 61,887,000 53,325,000 102,621,000 33,446,000 35,544,000 -8,450,000 5,397,000 -5,930,000 901,000 -11,853,000 3,753,000 -3,993,000 6,789,000 -13,293,000 4,828,000 469,000 4,762,000 -4,867,000 -11,204,000 -2,632,000 7,546,000 1,482,000 16,781,000 633,000 -765,000 -7,574,000 1,115,000 2,728,000 -4,007,000 3,561,000 663,000 1,550,000 -1,590,000 -1,866,000 1,522,000 40,000 121,000 -2,157,000 -1,651,000 1,210,000 -931,000 1,189,000 670,000 -156,000 -242,000  1,434,000 2,125,000 -1,172,000  -267,000 793,000 -231,000 1,165,000 -209,000 697,000 -1,059,000   -221,000 -2,184,000  1,738,000 3,681,000 224,000 -1,582,000        
          gain on sale of assets
                                                                                                    
          proceeds from sale of assets
                                                                                                    
          right-of-use assets written off
                          4,410,000                                                                          
          receivables, prepaid expenses and other assets
                          16,217,000 -27,201,000 220,205,000                                                                        
          acquisition of novavax cz, net of cash required
                                                                                                    
          effect of exchange rate on cash, cash equivalents and restricted cash
                          -5,860,000 1,001,000 -1,349,000 2,082,000 -243,000 349,000 -73,000 37,000 -47,000 23,000 -45,000 14,000 -26,000 -10,000 -26,000                                                            
          net increase in cash, cash equivalents and restricted cash
                          -175,913,000 93,669,000 1,380,332,000 247,002,000 -129,838,000 344,382,000 105,012,000    24,240,000                                                                
          cash, cash equivalents and restricted cash at beginning of period
                          648,738,000  82,180,000  81,959,000  135,431,000                                                            
          cash, cash equivalents and restricted cash at end of period
                          -175,913,000 93,669,000 2,029,070,000  -129,838,000 344,382,000 187,192,000  -2,305,000 -27,964,000 106,199,000  -24,523,000 -34,282,000 133,841,000                                                            
          other
                           -2,507,000 6,362,000 -12,385,000 -2,326,000   3,600,000 1,283,000 -14,000 -576,000 -753,000 -632,000 -435,000 247,000 1,121,000   105,000 104,000 99,000 98,000 103,000 62,000 -68,000 146,000                                                
          proceeds from the exercise of stock-based awards
                            26,750,000 8,761,000                                                                       
          treasury stock related to tax withholding on stock-based awards
                            -2,651,000 -2,063,000                                                                       
          non-cash impact of lease termination
                                     -4,381,000                                                            
          amortization of debt issuance costs
                             356,000 356,000 356,000 356,000 356,000 356,000 356,000 356,000 357,000 355,000 356,000 356,000 356,000 356,000 356,000 356,000 356,000 356,000 356,000 237,000                                                    
          accounts receivable, prepaid expenses and other assets
                                                                                                    
          cash, cash equivalents and restricted cash at beginning of year
                                                                                                    
          cash, cash equivalents and restricted cash at end of year
                                                                                                    
          loss on disposal of property and equipment
                                 88,000 -10,000 2,000 -47,000 -25,000 -2,000 231,000 65,000         -17,000                  29,000                             
          gain on catalent transaction
                                                                                                   
          write off of right-of-use assets
                                                                                                    
          proceeds from catalent transaction
                                                                                                   
          prepaid expenses and other assets
                               -65,600,000 4,521,000 -5,528,000 -1,291,000 2,913,000 -296,000 -481,000 1,304,000   2,163,000 -1,442,000 776,000 1,093,000 -713,000 -1,590,000 401,000 -1,289,000 -3,733,000 -3,087,000 -958,000 -2,491,000 -1,525,000 -307,000 -1,516,000 -237,000 -63,000 648,000 54,000 -329,000 -125,000 183,000       416,000    151,000     347,000 59,000   -260,000 219,000   43,000 397,000  114,000 -1,363,000 -79,000 -60,000        
          acquisition of praha vaccines a.s., net of cash acquired
                                                                                                    
          proceeds from the exercise of stock options and employee stock purchases
                               8,950,000 5,000 50,000 942,000 283,000 1,020,000 117,000 1,325,000 19,000 336,000 797,000 9,000 1,419,000 374,000 2,000,000 361,000 1,625,000 758,000 2,057,000 778,000 165,000 1,345,000                                             
          property and equipment purchases included in accounts payable and accrued expenses
                               2,628,000 125,000  37,000 -48,000 194,000  -35,000 99,000 62,000  -605,000 -137,000 823,000  -652,000 -468,000 3,180,000  225,000 -953,000 3,118,000 159,000 626,000 214,000  -619,000 604,000 422,000                                         
          cash payments of interest
                               6,094,000  6,094,000 6,094,000  6,094,000 6,094,000  6,094,000 6,094,000  6,165,000 9,000 12,000  22,000 26,000 31,000 43,000 48,000 52,000  59,000 41,000 20,000                                         
          lease incentives received
                                         448,000 237,000 1,248,000          703,000 1,803,000 1,000,000                                      
          net cash used in operating activities
                                                                                                    
          net cash provided by investing activities
                                                                                                    
          principal payments of capital leases
                                                        -33,000                                            
          net cash provided by financing activities
                                                                                                    
          net decrease in cash, cash equivalents and restricted cash
                                  -2,305,000    -24,523,000 -34,282,000 -1,590,000                                                            
          other liabilities
                                            543,000 2,753,000 9,000 -15,000 -1,535,000                                                    
          principal payments of notes payable
                                                        -168,000 -169,000 -97,000 -39,000 -7,000 -13,000 -20,000 -20,000 -20,000 -20,000 -20,000 -26,000 -2,742,000 -11,539,000 -807,000  -170,000 -170,000 -658,000  -248,000 -201,000 -285,000  -222,000 -221,000 -217,000                 
          payments for capped call transactions and costs
                                             -38,521,000                                                    
          principal payments on capital lease
                                          -19,000 -18,000                                                        
          restricted cash
                                         11,321,000 6,922,000 -18,343,000 5,880,000 -1,679,000 2,610,000 1,092,000 1,278,000 -36,501,000 297,000 203,000 133,000 1,081,000 -1,293,000 -124,000 217,000 769,000 -839,000 -755,000                                      
          changes in restricted cash
                                                                                                 
          effect of exchange rate on cash and cash equivalents
                                         -38,000 119,000 30,000 31,000 -198,000 -142,000 -32,000 37,000 -45,000 -25,000 -1,000 -79,000 9,000 -40,000 10,000 -12,000                                            
          net increase in cash and cash equivalents
                                         2,062,000   -48,506,000 24,405,000 30,553,000 -42,830,000 39,117,000 -45,036,000 -29,240,000 -47,666,000 182,715,000    -3,022,000 119,919,000   -4,596,000 1,461,000 -231,000 1,226,000 4,734,000 297,000    4,768,000 5,587,000 -7,309,000 18,742,556,000 13,281,000 8,811,000 10,352,000  8,479,000 -445,000 621,000                     
          cash and cash equivalents at beginning of year
                                                                                                    
          cash and cash equivalents at end of year
                                                                                                    
          net cash proved by (used in) investing activities
                                                                                                    
          principal payments on notes payable
                                              -104,000 -103,000 -143,000  -143,000 -151,000 -164,000 -167,000 -170,000 -168,000                                             
          cash and cash equivalents at beginning of period
                                          144,353,000  93,108,000  32,335,000 119,471,000  17,399,000 14,104,000 8,061,000 38,757,000 26,938,000  4,350,000  7,161,000  31,893,000  17,876,000  27,633,000  3,005,000  20,045,000 
          cash and cash equivalents at end of period
                                          28,452,000 -20,054,000 95,847,000  30,553,000 -42,830,000 132,225,000  -29,240,000 -47,666,000 215,050,000 -69,384,000 -6,064,000 109,921,000  119,919,000 -6,449,000 9,023,000 -4,596,000 1,461,000 13,873,000 1,226,000 4,734,000 8,358,000 6,769,000 -5,129,000 14,575,000 4,768,000 5,587,000 19,629,000  13,281,000 8,811,000 14,702,000  8,479,000 -445,000 7,782,000  -57,307,000 -5,340,000 83,941,000  2,502,000 -4,760,000 9,202,000  11,880,000 -6,262,000 21,885,000  -3,580,000 -4,695,000 14,320,000  -8,297,000 5,042,000 10,885,000 
          net decrease in cash and cash equivalents
                                                      -6,064,000 -9,550,000    -8,376,000        -5,129,000 -24,182,000                                
          amortization of net premiums on marketable securities
                                            -6,000 -6,000 -23,000 140,000 146,000 262,000 362,000 166,000 427,000                                                
          realized gains on marketable securities
                                                                                                    
          accounts receivable
                                             356,000 -236,000 26,000 1,926,000       -2,559,000              -131,000    -145,000 557,000 20,000                         
          proceeds from disposal of property and equipment
                                                     27,000   33,000 2,000 30,000 51,000 151,000          1,000 6,000                             
          proceeds from sales, maturities and redemptions of marketable securities
                                                                                                    
          cash paid with acquisition
                                                                                                    
          deferred rent
                                              566,000 29,000 -193,000 -167,000 -189,000 -170,000 -195,000 -257,000 -258,000 213,000 219,000 220,000 218,000 240,000 185,000 -85,000 336,000 -86,000 -85,000 -83,000 -75,000 -59,000 -72,000 -70,000 -71,000 -66,000  -3,060,000 2,996,000 -1,000  29,000 152,000 129,000 -33,000 -32,000 -16,000 -16,000  25,000    -5,000 9,000 8,000         
          principal payments on capital leases
                                              -16,000 -18,000 -19,000  -16,000 -17,000 -16,000 -26,000 -26,000 -6,000                                             
          change in fair value of warrant liability
                                                            -101,000 -736,000 -1,304,000 67,000                                   
          accounts receivable – billed
                                                 747,000 139,000 4,346,000 1,018,000 829,000                                               
          accounts receivable – unbilled
                                                 1,266,000 361,000 1,698,000 -1,096,000 606,000                                               
          net cash received from acquisition
                                                                                                    
          proceeds from notes payable
                                                        641,000 809,000 550,000 100,000                                      
          net proceeds from sales of common stock, net of offering costs of 11.9 million, 7.1 million and 6.1 million, respectively
                                                                                                    
          common stock issued in connection with acquisition
                                                                                                    
          cash paid with the novavax ab acquisition
                                                                                                   
          amortization of net premiums on investments
                                                     186,000 -179,000 99,000 181,000 94,000 138,000 94,000                                         
          realized gains on investments
                                                     -615,000                                             
          net cash received from novavax ab acquisition
                                                                                                    
          proceeds from sales and maturities of investments
                                                                                                    
          purchases of investments
                                                     -56,096,000   -6,036,000 -8,718,000                                         
          net proceeds from sales of common stock, net of offering costs of 7.1 million and 6.1 million, respectively
                                                                                                    
          commons stock issued in connection with the novavax ab acquisition
                                                                                                    
          proceeds from maturities of investments
                                                      2,850,000 10,590,000  13,981,000 4,414,000 5,235,000                                         
          net proceeds from sales of common stock, net of offering costs of 7.1 million and 0.3 million, respectively
                                                                                                    
          gain on disposal of property and equipment
                                                       3,000  6,000 -26,000 -17,000 -7,000                                        
          unbilled receivables
                                                       -1,125,000 -1,794,000 -1,379,000 -244,000 -1,000 2,506,000 -2,822,000 427,000 -1,828,000 -1,186,000 -834,000                                   
          net proceeds from sales of common stock, net of offering costs of 0.2 million
                                                                                                    
          sale of common stock under the 2012 sales agreement not settled at quarter-end
                                                           376,000                                         
          other non-cash income
                                                                                                    
          accounts receivables
                                                        -160,000 -395,000 1,695,000 -1,591,000 -971,000 227,000 240,000 1,815,000 -1,815,000 37,000                                   
          net cash received from the isconova ab acquisition
                                                                                                   
          proceeds from maturities and redemptions of investments
                                                                                                    
          proceeds from settlement of notes receivable from former directors
                                                                                                    
          net proceeds from sales of common stock, net of offering costs of 6.1 million, 0.4 million and 0.2 million, respectively
                                                                                                    
          proceeds from the exercise of stock options
                                                        304,000 924,000 269,000 1,000 23,000 22,000 4,000 41,000 59,000 56,000 10,000 349,000 64,000 757,000 35,000  112,000 102,000 35,000  5,000 84,000 701,000 40,000 179,000 798,000                 
          common stock issued in connection with the isconova ab acquisition
                                                                                                   
          deposit applied towards the purchase of equipment
                                                                                                    
          equipment acquired under a capital lease
                                                                                                    
          settlement of notes receivable from former directors
                                                                                                    
          sale of common stock under the 2010 sales agreement not settled at year-end
                                                                                                    
          net proceeds from sales of common stock, net of offering costs of 6.1 million and 0.4 million, respectively
                                                                                                    
          deposit applied towards the purchase of laboratory equipment
                                                                                                   
          principal payments of capital lease
                                                          -15,000 -14,000                                         
          net proceeds from sales of common stock, net of offering costs of 0.3 million and 0.3 million, respectively
                                                                                                    
          net proceeds from sales of common stock, net of offering costs of 0.2 million and 0.1 million, respectively
                                                           6,425,000                                         
          amortization of net premiums on short-term investments
                                                               86,000                                     
          impairment of property and equipment
                                                                                                   
          proceeds from maturities of short-term investments
                                                              4,860,000 6,850,000 8,525,000 10,100,000   2,450,000 125,000  3,925,000 13,850,000 31,745,000  31,500,000                       
          purchases of short-term investments
                                                            -6,374,000 -6,891,000 -2,498,000 -1,000,000 -583,000 -499,000 -13,346,000 -17,000 -14,182,000     -15,650,000  -13,507,000 -28,363,000 -24,848,000                     
          net proceeds from sales of common stock, net of offering costs of 0.4 million and 0.2 million, respectively
                                                                                                    
          settlement of notes receivable
                                                                                                    
          net proceeds from sales of common stock, net of offering costs of 0.3 million and 0.2 million, respectively
                                                                                                    
          equipment purchases included in accounts payable and accrued expenses
                                                             54,000 224,000                                      
          net proceeds from sales of common stock, net of offering costs of 0.1 million and less than 0.1 million, respectively
                                                              7,923,000                                      
          deposit included in other current assets at december 31, 2011 applied towards the purchase of laboratory equipment
                                                              500,000                                      
          loss of disposal of property and equipment
                                                                                                    
          prepaid expenses and other current assets
                                                               -491,000 -541,000 -95,000 104,000 246,000 597,000   -150,000    196,000     -54,000                    
          net cash from by investing activities
                                                               3,624,000 6,130,000 7,985,000                                   
          net proceeds from sales of common stock, net of offering costs of 0.2 million and 0.4 million, respectively
                                                                                                    
          equipment purchases included in accounts payable
                                                               134,000   -169,000 201,000 96,000 -79,000 37,000 47,000  415,000 -927,000 1,128,000                         
          net income:
                                                                -4,993,000 -7,453,000 -10,356,000 -9,426,000 -11,412,000         -8,966,000                       
          amortization of short-term investments premium
                                                                 150,000                                   
          amortization of debt discount
                                                                     -71,000 115,000 103,000  103,000 102,000 102,000                         
          amortization of deferred financing costs
                                                                     77,000 81,000 64,000  52,000 64,000 65,000  65,000 64,000 65,000 315,000 65,000 147,000 270,000  103,000 103,000 103,000             
          impairment of short-term investments
                                                                     -692,000 459,000 879,000                             
          realized gains on short-term investments
                                                                                                    
          accounts and other receivables
                                                                  -243,000 -125,000 27,000   216,000      -776,000                       
          net proceeds from sales of common stock, net of offering costs of 0.4 million and 1.0 million, respectively
                                                                                                    
          payment of notes payable through issuance of common stock
                                                                                                    
          amortization of short-term investments discount
                                                                                                    
          net proceeds from sales of common stock, net of offering costs of 0.1 million and 1.0 million, respectively
                                                                                                    
          less net income from discontinued operations
                                                                                                    
          net income from continuing operations
                                                                     -7,530,000 -8,540,000 -8,349,000                             
          reconciliation of net income from continuing operations to net cash from operating activities:
                                                                                                    
          depreciation
                                                                     297,000 308,000 294,000  161,000 211,000 209,000   698,000 707,000 747,000 737,000 724,000 713,000  666,000 718,000 708,000  573,000 545,000 484,000 148,000        
          reserve for notes receivable and accrued interest
                                                                           194,000  -153,000 -71,000 1,011,000                     
          loss and disposal of property and equipment
                                                                                                   
          impairment of long lived assets
                                                                        148,000                           
          amortization of net discounts on short-term investments
                                                                         -3,000 -31,000 -147,000  -558,000 -669,000 -698,000                     
          non-cash stock compensation
                                                                     416,000 357,000 497,000  500,000 696,000 450,000  590,000 483,000 356,000 309,000 373,000 551,000 1,034,000  306,000               
          other assets
                                                                                                    
          net cash from operating activities from continuing operations
                                                                     -6,417,000 -7,300,000 -6,727,000  -10,834,000 -1,249,000 -7,215,000                         
          net cash from operating activities from discontinued operations
                                                                         416,000 -721,000 2,013,000                         
          proceeds from leasehold improvement allowance
                                                                                                    
          net cash from investing activities from continuing operations
                                                                     2,262,000 -104,000 68,000  6,187,000 11,208,000 14,464,000                         
          net cash from investing activities from discontinued operations
                                                                         220,000 1,134,000                         
          net proceeds from the sales of common stock, net of offering costs of 1.0 million and 0.4 million
                                                                                                    
          repayment of notes payable through issuance of common stock
                                                                     2,560,000                               
          plus net income from discontinued operations
                                                                                                    
          net proceeds from the sales of common stock, net of offering costs of 1.0 million
                                                                                                    
          net cash provided (used in) by financing activities
                                                                                                    
          other non-current assets
                                                                           -28,000      -3,000                   
          bank overdraft
                                                                           579,000  309,000 -616,000 790,000                     
          net cash (used in) financing activities
                                                                       -650,000                             
          summary of cash flows:
                                                                                                    
          net cash provided by:
                                                                                                    
          operating activities
                                                                                                    
          investing activities
                                                                                                    
          financing activities
                                                                                                    
          net proceeds
                                                                                                    
          sales of common stock in equity offerings
                                                                                                    
          license payments received
                                                                                                    
          exercise of stock options and warrants
                                                                                                    
          amortization of intangible assets
                                                                                                    
          benefit from bad debts
                                                                             -38,000 150,000 68,000 194,000 21,000 37,000 -141,000                 
          reserve for notes and accrued interest receivable
                                                                         -1,311,000                           
          loss on disposal of capital assets
                                                                                                    
          interest income correction of an error
                                                                                                    
          proceeds from the sale of common stock, net of issuance costs
                                                                                                    
          net cash from financing activities from discontinued operations
                                                                                                    
          debt discount from modification of convertible debt
                                                                                                   
          income from continuing operations
                                                                          -8,314,000 -7,103,000                         
          retirement of capital assets
                                                                          55,000 18,000     76,000 260,000                  
          non-cash expense for services
                                                                             2,000 27,000                   
          sales of common stock in public offerings
                                                                                                    
          sales of product assets
                                                                                                    
          facility exit costs
                                                                                  -42,000 -42,000  190,000 -47,000 -38,000             
          purchase of treasury stock
                                                                                -1,000                    
          conversion of convertible debt and accrued interest to common stock
                                                                                7,068,000                 
          amortization
                                                                              33,000 33,000 33,000 33,000 33,000 33,000  205,000 215,000 216,000  235,000 163,000 164,000 164,000        
          supplemental disclosures:
                                                                                                    
          trade accounts receivable
                                                                               300,000  679,000 -261,000 111,000  36,000 -498,000 180,000  1,403,000 -997,000 -401,000         
          proceeds from maturities of short-term investment
                                                                               32,133,000                     
          non-cash transactions:
                                                                                                    
          reserve for note receivable and accrued interest
                                                                                                    
          gain on redemption of debt
                                                                                                    
          gain on sales of product assets
                                                                                                    
          net proceeds from sales of product assets
                                                                                                    
          net cash used by operating activities
                                                                                            -3,302,000 -3,038,000       
          net proceeds from issuance of convertible notes
                                                                                                    
          net payments associated with king transaction
                                                                                                    
          principal payments on notes payables
                                                                                                    
          net proceeds from issuance of common stock
                                                                                3,000                    
          net change in cash and cash equivalents
                                                                                  -5,340,000 52,048,000 24,949,000 2,502,000 -4,760,000 -8,674,000 -9,627,000 11,880,000 -6,262,000 -5,748,000 21,588,000 -3,580,000   -4,625,000 -8,297,000 5,042,000 -9,160,000 
          supplemental disclosure of non-cash transactions:
                                                                                                    
          financed insurance premiums
                                                                                                    
          treasury stock reissued for accrued interest to king
                                                                                                    
          cash paid for interest
                                                                                                    
          amortization of discounts/premiums on short-term investments
                                                                                                    
          reserve for non-current note and accrued interest receivable
                                                                                                    
          purchases of investment securities
                                                                                                    
          proceeds from sale and maturity of investment securities
                                                                                                    
          decrease in cash and cash equivalents
                                                                                                    
          net cash provided by/(used in) financing activities
                                                                                                    
          cash interest payments:
                                                                                                    
          non-cash expense
                                                                                   25,000                 
          other non current assets
                                                                                     118,000 6,000 32,000  357,000 -278,000 -22,000         
          net cash provided/(used) in financing activities
                                                                                   56,603,000                 
          net income per share
                                                                                                    
          weighted shares outstanding
                                                                                                    
          net cash (used) provided by:
                                                                                                    
          beginning cash and cash equivalents
                                                                                                    
          ending cash and cash equivalents
                                                                                                    
          gain on sale of product assets
                                                                                                    
          net proceeds from sale of product assets
                                                                                                    
          accounts payable and accrued expenses and other liabilities
                                                                                                    
          principal payments of capital lease obligations
                                                                                     -315,000 -309,000 -307,000             
          provision for bad debts
                                                                                      -9,000 21,000             
          proceeds from exercise of stock options and warrants
                                                                                                    
          reconciliation of net income to net cash used by operating activities:
                                                                                                    
          benefit from bad debt
                                                                                         116,000 16,000 43,000 118,000        
          deferred financing
                                                                                         80,000 25,000 26,000         
          net proceeds from the issuance of convertible notes.
                                                                                                    
          net proceeds from equipment loans
                                                                                                   
          net cash from financing activities.
                                                                                                    
          principal payments of notes and capital lease obligations
                                                                                          -399,000 -334,000         
          proceeds from sales of common stock
                                                                                          305,000 64,000         
          loss on disposal/sale of asset
                                                                                                    
          deferred rent expense
                                                                                            10,000        
          acquisition of product lines
                                                                                                    
          borrowing of long-term debt
                                                                                                    
          payment of capital lease obligations
                                                                                            -66,000        
          proceeds from the exercise of stock options and warrants
                                                                                            86,000 69,000       
          non-cash transactions
                                                                                                    
          cashless stock option exercises
                                                                                                    
          net cash used by investing activities
                                                                                             -583,000       
          proceeds from the issuance of convertible notes
                                                                                                    
          deferred financing costs
                                                                                             27,000       
          proceeds from private placements of common stock
                                                                                                   
          payments of capital lease obligations
                                                                                                    
          non-cash compensation expense
                                                                                                    
          non-cash net interest
                                                                                                    
          acquisition of businesses, net of cash acquired
                                                                                                    
          deferred patent costs
                                                                                                    
          adjustments to reconcile net income to net cash used by
                                                                                                    
          adjustments to reconcile net loss to net cash used by operating activities:
                                                                                                    
          acquisition of product line