7Baggers

KalVista Pharmaceuticals, Inc
(NASDAQ:KALV) 

KALV stock logo

KalVista Pharmaceuticals, Inc., a clinical stage pharmaceutical company, discovers, develops, and commercializes small molecule protease inhibitors for diseases with unmet needs. The company's product portfolio comprises small molecule plasma kallikrein inhibitors targeting hereditary angioedema (HA...

Founded: 2004
Full Time Employees: 56
Sector: Healthcare
Industry: Biotechnology
Pharmaceuticals
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At a glance:
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Income Statements:
Quarterly
Annual
    Unit: USD2026-03-31 2025-09-30 2025-07-31 2025-04-30 2025-01-31 2024-10-31 2024-07-31 2024-04-30 2024-01-31 2023-10-31 2023-07-31 2023-04-30 2023-01-31 2022-10-31 2022-07-31 2022-04-30 2022-01-31 2021-10-31 2021-07-31 2021-04-30 2021-01-31 2020-10-31 2020-07-31 2020-04-30 2020-01-31 2019-10-31 2019-07-31 2019-04-30 2019-01-31 2018-10-31 2018-07-31 2018-04-30 2018-01-31 2017-10-31 2017-07-31 2017-04-30 2017-01-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 
                                                
      product revenue
    		39,165,000 13,692,000 1,426,000                                          
      partnership and other revenue
    		1,698,000                                            
      total revenues
    		40,863,000                                            
      yoy
    		                                            
      qoq
    		                                            
      operating expenses:
    		                                            
      cost of revenue
    		3,090,000 1,232,000 590,000                                          
      research and development
    		12,420,000 11,993,000 15,162,000 15,891,000 12,594,000 16,610,000 26,614,000 25,248,000 22,523,000 19,089,000 19,307,000 23,951,000 20,063,000 18,077,000 18,186,000 19,213,000 19,738,000 17,546,000 13,669,000 11,877,000 9,097,000 9,148,000 11,165,000 9,485,000 11,233,000 9,789,000 9,686,000 5,970,500 7,650,000 7,876,000 8,356,000 3,096,250 4,548,000 4,361,000 3,476,000 2,417,500 3,339,000 332,000 947,000 3,532,000 4,260,000 3,533,000 4,504,000 3,902,000 
      selling, general and administrative
    		48,795,000 46,517,000 44,683,000                                          
      total operating expenses
    		64,305,000 59,742,000 60,435,000 55,030,000 42,940,000 45,811,000 44,215,000 48,455,000 33,151,000 29,746,000 29,093,000 31,728,000 26,945,000 25,883,000 26,316,000 26,811,000 26,683,000 23,603,000 19,516,000 18,042,000 12,657,000 12,781,000 14,443,000 12,781,000 14,301,000 13,209,000 12,933,000 14,186,000 10,550,000 10,485,000 10,727,000 7,809,000 6,677,000 7,064,000 5,549,000 5,200,000 8,365,000 2,412,000 6,971,000 6,535,000 5,577,000 4,906,000 5,674,000 4,908,000 
      operating income
    		-23,442,000 -46,050,000 -59,009,000 -55,030,000 -42,940,000 -45,811,000 -44,215,000 -48,455,000 -33,151,000 -29,746,000 -29,093,000 -31,728,000 -26,945,000 -25,883,000 -26,316,000 -26,811,000 -26,683,000 -23,603,000 -19,516,000 -18,042,000 -12,657,000 -12,781,000 -14,443,000 -8,957,000 -12,724,000 -9,289,000 -9,564,000 -11,260,000 -6,660,000 -4,893,000 -7,009,000 -2,969,000 -4,346,000 -5,937,000 -5,453,000 -5,086,000 -8,117,000        
      yoy
    		-45.41% 0.52% 33.46% 13.57% 29.53% 54.01% 51.98% 52.72% 23.03% 14.92% 10.55% 18.34% 0.98% 9.66% 34.84% 48.60% 110.82% 84.67% 35.12% 101.43% -0.53% 37.59% 51.01% -20.45% 91.05% 89.84% 36.45% 279.25% 53.24% -17.58% 28.53% -41.62% -46.46%            
      qoq
    		-49.09% -21.96% 7.23% 28.16% -6.27% 3.61% -8.75% 46.16% 11.45% 2.24% -8.30% 17.75% 4.10% -1.65% -1.85% 0.48% 13.05% 20.94% 8.17% 42.55% -0.97% -11.51% 61.25% -29.61% 36.98% -2.88% -15.06% 69.07% 36.11% -30.19% 136.07% -31.68% -26.80% 8.88% 7.22% -37.34%         
      operating margin %
    		-57.37% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% NaN% NaN% NaN% NaN% NaN% NaN% NaN% 
      other income:
    		                                            
      interest income
    		2,548,000 1,875,000 1,849,000 1,992,000 1,394,000 1,357,000 1,692,000 1,513,000 684,000 776,000 923,000 808,000 732,000 449,000 242,000 268,000 258,000 290,000 274,000 314,000 137,000 193,000 259,000 363,000 372,000 505,000 590,000 381,000 723,000 204,000 89,000 65,000 14,000 1,000 2,000 5,000 7,000 19,000 20,000 12,000 1,000 2,000 2,000  
      interest expense
    		-5,586,000 -4,757,000 -3,522,000                                    -406,000 -88,000 -88,000 -95,000 -169,000 -836,000 
      foreign currency exchange gain
    		-52,000 -884,000 1,925,000 2,882,000 -983,000 67,000 514,000 -139,000 1,120,000  456,000 327,000 597,000 -317,000 -517,000 -1,008,000 -198,000 -280,000 -51,000 132,000 301,000 -24,000 438,000 -612,000 138,000 560,000 -453,000 20,750 248,000 -231,000 67,000 -459,000 -1,887,000 83,000 -32,000 377,750 -195,000        
      other income
    		3,045,000 2,491,000 818,000 1,198,500 1,109,000 2,119,000 1,566,000 1,833,750 2,319,000 2,619,000 2,397,000 2,838,500 4,313,000 3,494,000 3,549,000 3,438,000 4,156,000 3,943,000 3,184,000 2,640,000 2,171,000 2,186,000 2,932,000 2,498,000 2,923,000 2,321,000 2,089,000 2,511,000 1,733,000 1,616,000 1,823,000 1,985,000 985,000 867,000 555,000 1,019,000 661,000 1,000  -3,000 -3,000 1,000 -1,000 553,000 
      total other income
    		-45,000 -1,275,000 1,070,000 1,949,000 -1,322,000 3,543,000 3,772,000 3,806,000 4,123,000 2,096,000 3,776,000 5,423,000 5,642,000 3,626,000 3,274,000 2,698,000 4,216,000 3,953,000 3,407,000 3,086,000 2,609,000 2,355,000 3,629,000 2,249,000 3,433,000 3,386,000 2,226,000 2,858,000 2,704,000 1,589,000 1,979,000 2,312,000 -888,000 951,000 525,000 884,000 473,000      -3,345,000 -283,000 
      loss before income tax expense
    		-23,487,000 -47,325,000                                           
      income tax expense
    		 2,157,000 2,157,000                                          
      net income
    		-23,487,000 -49,482,000 -60,096,000 -52,226,000 -48,509,000 -42,268,000 -40,443,000 -44,649,000 -29,028,000 -27,650,000 -25,317,000 -26,305,000 -21,303,000 -22,257,000 -23,042,000 -24,113,000 -22,467,000 -19,650,000 -16,109,000 -14,956,000 -10,048,000 -10,426,000 -10,814,000 -6,584,000 -9,291,000 -5,903,000 -7,338,000 -8,526,000 -3,956,000 -3,304,000 -5,030,000 -657,000 -5,234,000 -4,986,000 -4,928,000 -4,202,000 -7,644,000        
      yoy
    		-51.58% 17.07% 48.59% 16.97% 67.11% 52.87% 59.75% 69.74% 36.26% 24.23% 9.87% 9.09% -5.18% 13.27% 43.04% 61.23% 123.60% 88.47% 48.96% 127.16% 8.15% 76.62% 47.37% -22.78% 134.86% 78.66% 45.88% 1197.72% -24.42% -33.73% 2.07% -84.36% -31.53%            
      qoq
    		-52.53% -17.66% 15.07% 7.66% 14.77% 4.51% -9.42% 53.81% 4.98% 9.22% -3.76% 23.48% -4.29% -3.41% -4.44% 7.33% 14.34% 21.98% 7.71% 48.85% -3.63% -3.59% 64.25% -29.14% 57.39% -19.56% -13.93% 115.52% 19.73% -34.31% 665.60% -87.45% 4.97% 1.18% 17.28% -45.03%         
      net income margin %
    		-57.48% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% NaN% NaN% NaN% NaN% NaN% NaN% NaN% 
      other comprehensive income:
    		                                            
      foreign currency translation gain
    		280,000 911,000  97,500 352,000 166,000 -128,000 -93,250 -46,000  91,000 -31,000 1,128,000 -1,297,000 -403,000                              
      unrealized holding gain on marketable securities
    		-278,000 187,000 18,000 276,000 367,000 651,000 1,064,000 21,000 438,000 440,000 392,000 458,000 658,000 52,000 98,000   -295,000 -129,000 -54,250 -48,000 -164,000 -5,000                      
      reclassification adjustment for realized holding loss on marketable securities included in net loss
    		11,000                                            
      total other comprehensive income
    		13,000 327,000 -1,173,000                                          
      comprehensive loss
    		-23,474,000 -49,155,000 -61,269,000 -55,232,000 -48,016,000 -42,100,000 -39,824,000 -44,844,000 -28,857,000 -28,224,000    -23,433,000 -23,331,000 -25,635,000 -23,086,000 -19,881,000 -16,166,000 -15,121,000 -9,359,000 -10,763,000 -10,551,000 -7,084,000 -9,209,000 -5,380,000 -7,399,000 -8,351,000 -3,821,000 -3,111,000 -6,350,000 -1,630,000 -2,800,000 -5,029,000  -3,938,000 -7,478,000        
      weighted-average shares outstanding-basic and diluted
    		54,583,424,000 53,883,681,000                                           
      net income per share
    		  -1.12 -0.99 -0.92 -0.91 -0.87 -1.07 -0.84 -0.8 -0.74 -0.75 -0.75 -0.9 -0.94 -0.98 -0.92 -0.8 -0.66 -0.67 -0.56 -0.58 -0.61 -0.37 -0.52 -0.33 -0.42 -0.53 -0.23 -0.22 -0.47 -0.04 -0.49 -0.5 -0.51 1.03 -1.03 -0.09 -0.28 -0.25 -0.18 -0.19 -0.37 -7.38 
      basic and diluted
    		-0.43 -0.92                                           
      reclassification adjustment for realized holding gain on marketable securities included in net loss
    		 -771,000                                           
      income before income taxes
    		  -57,939,000                                          
      foreign currency translation loss
    		  -604,000       -419,000                                   
      reclassification adjustment for realized gain on marketable securities included in net loss
    		  -587,000                                          
      net income per share
    		  -1.12 -0.99 -0.92 -0.91 -0.87 -1.07 -0.84 -0.8 -0.74 -0.75 -0.75 -0.9 -0.94 -0.98 -0.92 -0.8 -0.66 -0.67 -0.56 -0.58 -0.61 -0.37 -0.52 -0.33 -0.42 -0.53 -0.23 -0.22 -0.47 -0.04 -0.49 -0.5 -0.51 1.03 -1.03 -0.09 -0.28 -0.25 -0.18 -0.19 -0.37 -7.38 
      weighted-average common shares outstanding, basic and diluted
    		  53,497,128 49,652,878 52,638,888 46,695,220 46,232,977 36,786,575 34,723,379 34,565,955 34,414,226 27,890,846 28,278,453 24,595,039 24,557,615 24,473,092 24,479,660 24,439,623 24,429,919 19,094,440 17,961,802 17,907,393 17,848,583 17,748,666 17,838,872 17,823,302 17,488,997 15,080,863 17,231,449 15,108,272 10,799,895 10,321,780 10,788,556 10,003,963 9,713,042 4,646,764 7,657,874 26,343,108 26,334,622 26,332,494 19,082,604 26,322,494 24,303,819 701,980 
      general and administrative
    		   39,139,000 30,346,000 29,201,000 17,601,000 23,207,000 10,628,000 10,657,000 9,786,000 7,777,000 6,882,000 7,806,000 8,130,000 7,598,000 6,945,000 6,057,000 5,847,000 6,165,000 3,560,000 3,633,000 3,278,000 3,296,000 3,068,000 3,420,000 3,247,000 1,969,750 2,900,000 2,609,000 2,371,000 1,726,250 2,129,000 2,703,000 2,073,000 2,243,250 5,026,000 2,080,000 2,604,000 1,543,000 1,317,000 1,373,000 1,170,000 1,006,000 
      interest expense related to the sale of future royalties
    		   -710,500 -2,842,000                                        
      net loss before income taxes
    		   -31,742,750 -44,262,000                                        
      provision for income taxes
    		   1,061,750 4,247,000                                        
      reclassification adjustment for realized (gain) on marketable securities included in net loss
    		   -298,000 -226,000 -649,000              -48,000 -76,000 -46,000 -70,000                      
      other comprehensive income
    		   320,000 493,000 168,000 619,000    169,000 79,750 1,785,000   -226,750 -619,000 -231,000 -57,000 153,750 689,000 -337,000 263,000 136,000 82,000 523,000  -248,000 135,000                
      revenue
    		                       3,824,000 1,577,000 3,920,000 3,369,000 2,926,000 3,890,000 5,592,000 3,718,000 4,840,000 2,331,000 1,127,000           
      reclassification adjustment for realized loss on marketable securities included in net loss
    		      -317,000 -282,500 -221,000 -595,000 -314,000 21,000 -1,000 69,000 16,000 74,000 176,000 97,000 23,000                          
      other comprehensive gain
    		       -58,250 171,000                                    
      foreign currency exchange loss
    		         -1,299,000                                   
      other comprehensive loss
    		         -574,000    -1,176,000 -289,000            -61,000                  
      comprehensive
    		          -25,148,000                                  
      comprehensive income
    		           -16,570,750 -19,518,000                      -4,812,000          
      foreign currency translation adjustments
    		               -107,500 -445,000 -33,000 49,000 52,000 813,000 -127,000 338,000 -489,000 142,000 495,000 -89,000 -33,000 -97,000 193,000 -1,320,000 -973,000 2,434,000 -43,000 116,000          
      unrealized holding loss on marketable securities
    		               -193,250 -350,000                            
      unrealized holding gains on available-for-sale securities
    		                       60,000 40,000 28,000 28,000 208,000 232,000                
      reclassification adjustment for realized (gain) on available-for-sale securities included in net loss
    		                       -57,250 -100,000                    
      other comprehensive loss:
    		                                            
      grant income
    		                                  96,000 114,000 248,000        
      currency translation adjustments
    		                                   -708,000 166,000        
      license revenue
    		                                     7,000 7,000 7,000 8,000 7,000 7,000 7,000 
      restructuring and lease termination charges
    		                                      3,420,000      
      impairment of long-lived assets
    		                                       1,460,000     
      income from operations
    		                                     -2,405,000 -6,964,000 -6,528,000 -5,569,000 -4,899,000 -5,667,000 -4,901,000 
      loss on extinguishment of convertible promissory notes
    		                                          -3,177,000  
      net loss and comprehensive loss
    		                                     -2,385,000 -7,350,000 -6,607,000 -5,659,000 -4,991,000 -9,012,000 -5,184,000 
      revised from a net loss of 1.12 per share to common stockholders, basic and diluted, and 17,203,279 weighted-average common shares outstanding, basic and diluted, as previously reported for the nine months ended september 30, 2015.
    		                                            
      revised from a net loss per share to common stockholders, basic and diluted, of 0.37 per share and 24,303,819 weighted-average common shares outstanding, basic and diluted, as previously reported for the three months ended june 30, 2015, and a net loss of 1.13 per share to common stockholders, basic and diluted, and 12,568,098 weighted-average common shares outstanding, basic and diluted, as previously reported for the six months ended june 30, 2015.
    		                                            
      net loss attributable to common stockholders
    		                                           -5,184,000 
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2026-03-31 2025-09-30 2025-07-31 2025-04-30 2025-01-31 2024-10-31 2024-07-31 2024-04-30 2024-01-31 2023-10-31 2023-07-31 2023-04-30 2023-01-31 2022-10-31 2022-07-31 2022-04-30 2022-01-31 2021-10-31 2021-07-31 2021-04-30 2021-01-31 2020-10-31 2020-07-31 2020-04-30 2020-01-31 2019-10-31 2019-07-31 2019-04-30 2019-01-31 2018-10-31 2018-07-31 2018-04-30 2018-01-31 2017-10-31 2017-07-31 2017-04-30 2017-01-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 
                                                  
        assets
      		                                            
        current assets:
      		                                            
        cash and cash equivalents
      		213,768,000 243,497,000 124,304,000 131,615,000 167,288,000 41,581,000 31,848,000 31,789,000 23,056,000 57,666,000 49,409,000 56,238,000 85,049,000 38,585,000 37,863,000 30,732,000 45,577,000 46,491,000 48,343,000 50,592,000 17,727,000 16,174,000 18,014,000 15,789,000 18,615,000 21,719,000 30,107,000 32,006,000 56,345,000 121,116,000 48,070,000 51,055,000 58,678,000 28,128,000 26,456,000 30,950,000 33,498,000 35,208,000 36,819,000 48,455,000 53,723,000 59,878,000 65,381,000 3,181,000 
        marketable securities
      		71,262,000 65,661,000 67,161,000 89,002,000 85,915,000 94,195,000 142,424,000 178,612,000 52,530,000 45,506,000 73,848,000 93,137,000 86,636,000 83,688,000 104,212,000 135,470,000 149,212,000 163,322,000 182,288,000 198,337,000 32,584,000 39,700,000 46,317,000 51,925,000 61,955,000 71,742,000 70,259,000 68,805,000                 
        accounts receivable
      		9,897,000 5,779,000 1,926,000                                          
        inventory
      		4,002,000 458,000                                           
        research and development tax credit receivable
      		7,430,000 1,343,000 561,000 1,383,000 7,485,000 11,082,000 9,908,000 8,439,000 23,011,000 19,976,000 19,057,000 16,568,000 11,892,000 20,029,000 17,248,000 14,098,000 11,287,000 17,399,000 13,613,000 10,418,000 7,589,000 14,685,000 12,638,000 16,527,000 14,803,000 11,814,000 12,625,000 11,315,000 8,970,000 7,032,000 5,604,000 6,834,000 4,989,000 3,718,000 2,822,000 2,250,000 2,840,000        
        prepaid expenses and other current assets
      		7,846,000 8,488,000 11,944,000 19,690,000 6,671,000 5,409,000 7,454,000 6,850,000 5,506,000 5,458,000 7,528,000 6,383,000 8,556,000 8,914,000 11,084,000 13,347,000 8,388,000 7,266,000 5,538,000 4,917,000 4,604,000 1,517,000 3,256,000 4,455,000 3,632,000 2,617,000 2,728,000 3,420,000 3,946,000 1,922,000 1,511,000 1,491,000 2,003,000 1,400,000 841,000 751,000 1,217,000 605,000 1,138,000 1,010,000 1,222,000 1,571,000 1,614,000 1,127,000 
        total current assets
      		314,205,000 325,226,000 205,896,000 241,690,000 267,359,000 152,267,000 191,634,000 225,690,000 104,103,000 128,606,000 149,842,000 172,326,000 192,133,000 151,216,000 170,407,000 193,647,000 214,464,000 234,478,000 249,782,000 264,264,000 62,504,000 72,076,000 80,225,000 88,696,000 99,005,000 107,892,000 115,719,000 115,546,000 124,063,000 130,070,000 55,185,000 59,380,000 65,710,000 34,139,000 30,192,000 34,248,000 37,953,000 35,813,000 37,957,000 49,465,000 54,945,000 61,449,000 66,995,000 4,308,000 
        property and equipment
      		2,841,000 3,190,000 2,067,000 1,988,000 1,807,000 2,039,000 2,100,000 2,227,000 2,423,000 2,502,000 2,813,000 2,948,000 3,037,000 3,060,000 3,030,000 2,178,000 2,215,000 2,180,000 1,944,000 1,791,000 1,868,000 1,889,000 2,019,000 2,043,000 2,260,000 2,365,000 2,255,000 2,413,000 2,289,000 2,316,000 2,260,000 1,836,000 774,000 602,000 592,000 97,000 97,000   160,000 805,000 362,000 374,000 329,000 
        right of use assets
      		9,421,000 9,096,000 5,165,000 5,544,000 5,440,000 5,863,000 5,859,000 6,920,000 7,045,000 7,298,000 7,571,000 7,822,000 8,101,000 8,365,000 8,664,000 7,862,000 8,180,000 6,959,000 7,207,000 5,758,000 1,653,000 1,305,000 1,480,000 1,612,000 1,497,000 1,634,000 1,737,000                  
        other assets
      		2,450,000 2,419,000 2,377,000 1,548,000 1,387,000 662,000 605,000 567,000 397,000 337,000 106,000 106,000 197,000 197,000 218,000 193,000 193,000 193,000 200,000 200,000 181,000 178,000 178,000 178,000 173,000 173,000 173,000 173,000 173,000 173,000 173,000 173,000 173,000        991,000 218,000 179,000 179,000 
        total assets
      		328,917,000 339,931,000 215,505,000 250,770,000 275,993,000 160,831,000 200,198,000 235,404,000 113,968,000 138,743,000 160,332,000 183,202,000 203,468,000 162,838,000 182,319,000 203,880,000 225,052,000 243,810,000 259,133,000 272,013,000 66,206,000 75,448,000 83,902,000 92,529,000 102,935,000 112,064,000 119,884,000 118,132,000 126,525,000 132,559,000 57,618,000 61,389,000 66,657,000 34,741,000 30,784,000 34,345,000 38,050,000 35,863,000 38,007,000 49,675,000 56,791,000 62,079,000 67,598,000 7,712,000 
        liabilities and stockholders’ deficit
      		                                            
        current liabilities:
      		                                            
        accounts payable
      		8,045,000 8,074,000 5,869,000 4,883,000 5,856,000 5,198,000 10,792,000 9,107,000 3,101,000 4,896,000 5,060,000 4,817,000 1,698,000 3,384,000 2,908,000 3,638,000 2,185,000 3,159,000 1,448,000 1,981,000 641,000 2,173,000 1,774,000 1,677,000 2,951,000 2,238,000 3,103,000 2,860,000 2,998,000 3,018,000 2,345,000 1,433,000 1,575,000 1,040,000 1,943,000 1,153,000 755,000 431,000 187,000 793,000 1,460,000 1,527,000 1,992,000 2,545,000 
        accrued expenses and other current liabilities
      		34,022,000                                            
        deferred revenue - current portion
      		833,000                        1,343,000 2,601,000 6,023,000 9,545,000 12,311,000 14,769,000 17,207,000 18,475,000 19,996,000            
        lease liability - current portion
      		1,691,000 1,429,000 2,122,000 1,977,000 1,444,000 1,537,000 1,264,000 1,302,000 1,187,000 1,148,000 1,122,000 1,087,000 1,057,000 1,026,000 997,000 977,000 1,014,000 930,000 905,000 863,000 592,000 422,000 513,000 588,000 592,000 602,000 580,000                  
        royalty obligation - current portion
      		16,226,000 3,287,000                                           
        total current liabilities
      		60,817,000 45,069,000 38,375,000 45,167,000 25,615,000 22,164,000 22,411,000 22,807,000 19,128,000 17,751,000 14,132,000 15,032,000 11,606,000 11,320,000 9,733,000 11,576,000 9,649,000 10,114,000 8,229,000 9,774,000 6,518,000 9,536,000 8,457,000 7,720,000 9,762,000 10,470,000 13,967,000 18,052,000 18,826,000 20,938,000 22,903,000 23,216,000 24,083,000 3,513,000 3,837,000 3,018,000 3,201,000 1,891,000 1,929,000 3,854,000 4,271,000 3,793,000 4,167,000 11,005,000 
        deferred revenue - net of current portion
      		21,357,000                        2,500,000 2,754,000 2,873,000 3,342,000 3,666,000 4,670,000 8,465,000 10,862,000 13,889,000            
        lease liability - net of current portion
      		10,411,000 9,128,000 4,019,000 4,330,000 4,338,000 4,675,000 4,988,000 6,015,000 6,257,000 6,546,000 6,865,000 7,145,000 7,421,000 7,705,000 8,014,000 7,211,000 7,467,000 6,224,000 6,474,000 5,046,000 1,123,000 932,000 1,010,000 1,057,000 926,000 1,053,000 1,177,000                  
        royalty obligation - net of current portion
      		116,583,000 129,707,000                                           
        convertible notes
      		139,401,000 139,028,000                                           
        total liabilities
      		348,569,000 322,932,000                                    1,926,000 1,971,000 6,604,000 7,481,000 7,458,000 8,274,000 17,125,000 
        stockholders’ deficit:
      		                                            
        common stock, 0.001 par value...
      		51,000 50,000                                    27,000 27,000 27,000 27,000 27,000 27,000 1,000 
        additional paid-in capital
      		773,594,000 762,776,000 760,393,000 753,725,000 748,231,000 689,087,000 685,794,000 679,754,000 516,920,000 513,926,000 510,591,000 507,133,000 504,725,000 444,588,000 441,914,000 439,104,000 436,313,000 432,763,000 429,840,000 426,437,000 212,694,000 209,750,000 208,442,000 207,208,000 206,119,000 204,950,000 203,650,000 191,123,000 190,067,000 189,164,000 105,358,000 100,011,000 99,696,000 99,408,000 90,036,000 89,815,000 89,399,000 122,873,000 122,586,000 122,272,000 121,904,000 121,556,000 121,268,000 3,989,000 
        accumulated deficit
      		-786,181,000 -739,098,000 -713,266,000 -653,170,000 -600,946,000 -552,437,000 -510,169,000 -469,726,000 -425,077,000 -396,049,000 -368,399,000 -343,082,000 -316,777,000 -295,474,000 -273,217,000 -250,175,000 -226,062,000 -203,595,000 -183,945,000 -167,836,000 -152,880,000 -142,832,000 -132,406,000 -121,592,000 -115,008,000 -105,717,000 -99,814,000 -92,476,000 -83,950,000 -79,994,000 -76,690,000 -71,660,000 -71,003,000 -65,769,000 -60,784,000 -55,855,000 -51,653,000 -88,963,000 -86,577,000 -79,228,000 -72,621,000 -66,962,000 -61,971,000 -52,959,000 
        accumulated other comprehensive loss
      		-7,116,000 -6,729,000 -6,387,000 -5,214,000 -2,208,000 -2,701,000 -2,869,000 -3,488,000 -3,294,000 -3,465,000 -2,891,000 -3,060,000 -3,541,000 -5,326,000 -4,150,000 -3,861,000 -2,339,000 -1,720,000 -1,489,000 -1,432,000 -1,267,000 -1,956,000 -1,619,000 -1,882,000 -1,382,000 -1,464,000 -1,987,000 -1,926,000 -2,101,000 -2,236,000 -2,429,000 -1,109,000 -136,000 -2,571,000 -2,528,000 -2,643,000 -2,907,000        
        total stockholders’ deficit
      		-19,652,000                                           -48,969,000 
        total liabilities and stockholders’ deficit
      		328,917,000                                            
        liabilities and stockholders' equity
      		                                            
        accrued expenses
      		 20,767,000 18,971,000 27,307,000 18,315,000 15,429,000 10,355,000 12,398,000 14,840,000 11,707,000 7,950,000 9,128,000 8,851,000 6,910,000 5,828,000 6,961,000 6,450,000 6,025,000 5,876,000 6,930,000 5,285,000 6,941,000 6,170,000 5,455,000 4,876,000 5,029,000 4,261,000 5,593,000 3,408,000 2,994,000 3,137,000 3,087,000 2,290,000 2,253,000 1,692,000 1,865,000 2,446,000 1,431,000 1,713,000 1,082,000 1,327,000 1,272,000 1,666,000 1,832,000 
        deferred revenue
      		 11,512,000 11,413,000 11,000,000                                         
        stockholders' equity:
      		                                            
        total stockholders' equity
      		 16,999,000                                           
        total liabilities and stockholders' equity
      		 339,931,000                                           
        liabilities and stockholders’ equity
      		                                            
        long-term liabilities:
      		                                            
        royalty obligation
      		  132,321,000                                          
        total long-term liabilities
      		  136,340,000 110,212,000 105,252,000 4,675,000 4,988,000 6,015,000 6,257,000 6,546,000 6,865,000 7,145,000 7,421,000 7,705,000 8,014,000 7,211,000 7,467,000 6,224,000 6,474,000 5,046,000 1,123,000 932,000 1,010,000 1,057,000 3,426,000 3,807,000 4,050,000 3,342,000 3,666,000 4,670,000 8,465,000 10,920,000 14,006,000 149,000 213,000          
        stockholders’ equity
      		                                            
        shares issued and outstanding: 50,339,823 at july 31, 2025 and 49,762,048 at april 30, 2025
      		  50,000                                          
        total stockholders’ equity
      		  40,790,000 95,391,000 145,126,000 133,992,000 172,799,000 206,582,000 88,583,000 114,446,000 139,335,000 161,025,000 184,441,000 143,813,000 164,572,000 185,093,000 207,936,000 227,472,000 244,430,000 257,193,000 58,565,000 64,980,000 74,435,000 83,752,000 89,747,000 97,787,000 101,867,000 96,738,000 104,033,000 106,951,000 26,250,000 27,253,000 28,568,000 31,079,000 26,734,000 31,327,000 34,849,000 33,937,000 36,036,000 43,071,000 49,310,000 54,621,000 59,324,000  
        total liabilities and stockholders’ equity
      		  215,505,000 250,770,000 275,993,000 160,831,000 200,198,000 235,404,000 113,968,000 138,743,000 160,332,000 183,202,000 203,468,000 162,838,000 182,319,000 203,880,000 225,052,000 243,810,000 259,133,000 272,013,000 66,206,000 75,448,000 83,902,000 92,529,000 102,935,000 112,064,000 119,884,000 118,132,000 126,525,000 132,559,000 57,618,000 61,389,000 66,657,000 34,741,000 30,784,000 34,345,000 38,050,000 35,863,000 38,007,000 49,675,000     
        deferred royalty obligation
      		   105,882,000 100,914,000                                        
        commitments and contingencies
      		                                            
        stockholders’ equity:
      		                                            
        shares issued and outstanding: 49,762,048 and 42,521,975 as of april 30, 2025 and 2024, respectively
      		   50,000                                         
        shares issued and outstanding: 49,493,210 at january 31, 2025 and 42,521,975 at april 30, 2024
      		    49,000                                        
        shares issued and outstanding: 43,271,501 at october 31, 2024 and 42,521,975 at april 30, 2024
      		     43,000                                       
        shares issued and outstanding: 43,081,922 at july 31, 2024 and 42,521,975 at april 30, 2024
      		      43,000                                      
        shares issued and outstanding: 42,521,975 and 34,171,138 as of april 30, 2024 and 2023, respectively
      		       42,000                                     
        shares issued and outstanding: 34,595,623 at january 31, 2024 and 34,171,138 at april 30, 2023
      		        34,000                                    
        shares issued and outstanding: 34,421,458 at october 31, 2023 and 34,171,138 at april 30, 2023
      		         34,000                                   
        shares issued and outstanding: 34,266,595 at july 31, 2023 and 34,171,138 at april 30, 2023
      		          34,000                                  
        shares issued and outstanding: 34,171,138 and 24,550,748 as of april 30, 2023 and 2022, respectively
      		           34,000                                 
        shares issued and outstanding: 34,127,762 at january 31, 2023 and 24,550,748 at april 30, 2022
      		            34,000                                
        shares issued and outstanding: 24,602,023 at october 31, 2022 and 24,550,748 at april 30, 2022
      		             25,000                               
        shares issued and outstanding: 24,570,872 at july 31, 2022 and 24,550,748 at april 30, 2022
      		              25,000                              
        shares issued and outstanding: 24,550,748 and 24,422,531 at april 30, 2022 and 2021, respectively
      		               25,000                             
        shares issued and outstanding: 24,537,094 at january 31, 2022 and 24,422,531 at april 30, 2021
      		                24,000                            
        shares issued and outstanding: 24,443,432 at october 31, 2021 and 24,422,531 at april 30, 2021
      		                 24,000                           
        shares issued and outstanding: 24,437,515 at july 31, 2021 and 24,422,531 at april 30, 2021
      		                  24,000                          
        shares issued and outstanding: 24,422,531 and 17,845,599 at april 30, 2021 and 2020, respectively
      		                   24,000                         
        shares issued and outstanding: 18,021,224 at january 31, 2021 and 17,845,599 at april 30, 2020
      		                    18,000                        
        shares issued and outstanding: 17,915,515 at october 31, 2020 and 17,845,599 at april 30, 2020
      		                     18,000                       
        shares issued and outstanding: 17,880,414 at july 31, 2020 and 17,845,599 at april 30, 2020
      		                      18,000                      
        shares issued and outstanding: 17,845,599 at april 30, 2020 and 17,277,750 at april 30, 2019
      		                       18,000                     
        shares issued and outstanding: 17,845,599 at january 31, 2020 and 17,277,750 at april 30, 2019
      		                        18,000                    
        shares issued and outstanding: 17,834,126 at october 31, 2019 and 17,277,750 at april 30, 2019
      		                         18,000                   
        shares issued and outstanding: 17,815,493 at july 31, 2019 and 17,277,750 at april 30, 2019
      		                          18,000                  
        capital lease liability - current portion
      		                           54,000 109,000 157,000 214,000 221,000 222,000 220,000           
        capital lease liability - net of current portion
      		                               58,000 117,000 149,000           
        shares issued and outstanding: 17,277,750 at april 30, 2019 and 10,799,895 at april 30, 2018
      		                           17,000                 
        investments
      		                            54,802,000                
        shares issued and outstanding: 17,247,306 at january 31, 2019 and 10,799,895 at april 30, 2018
      		                            17,000                
        shares issued and outstanding: 17,225,167 at october 31, 2018 and 10,799,895 at april 30, 2018
      		                             17,000               
        shares issued and outstanding: 10,799,895 at july 31, 2018 and at april 30, 2018
      		                              11,000              
        grants and other receivables
      		                                40,000 893,000           
        shares issued and outstanding: 10,799,895 at april 30, 2018 and 9,713,042 at april 30, 2017
      		                               11,000             
        common stock
      		                                            
        shares authorized: 100,000,000
      		                                            
        shares issued and outstanding: 10,792,646
      		                                11,000            
        shares issued and outstanding: 10,783,631
      		                                 11,000           
        grants receivable
      		                                  73,000 297,000 398,000        
        capital lease liability
      		                                  202,000          
        shares issued and outstanding: 9,713,042
      		                                  10,000          
        due to related parties
      		                                            
        series b convertible preferred stock, 0.0016 par value
      		                                            
        shares issued and outstanding: none at april 30, 2017 and 8,422,898 at april 30, 2016
      		                                            
        series a convertible preferred stock, 0.0016 par value
      		                                            
        shares issued and outstanding: none at april 30, 2017 and 15,900,000 at april 30, 2016
      		                                            
        total preferred stock
      		                                            
        ordinary shares, 0.0016 par value
      		                                            
        shares issued and outstanding: none at april 30, 2017 and 2,167,367 at april 30, 2016
      		                                            
        shares authorized: 100,000,000 at april 30, 2017
      		                                            
        shares issued and outstanding: 9,713,042 at april 30, 2017 and none at april 30, 2016
      		                                   10,000         
        redeemable convertible preferred stock
      		                                            
        shares issued and outstanding: none at january 31, 2017 and 24,322,898 at april 30, 2016
      		                                            
        shares issued and outstanding: none at january 31, 2017 and 2,167,367 at april 30, 2016
      		                                            
        shares authorized: 100,000,000 at january 31, 2017
      		                                            
        shares issued and outstanding: 9,713,042 at january 31, 2017 and none at april 30, 2016
      		                                    10,000        
        restricted cash
      		                                     50,000 50,000 50,000 50,000 50,000 50,000 50,000 
        loan payable
      		                                            
        deferred licensing revenue
      		                                     29,000 29,000 29,000 29,000 29,000 29,000 29,000 
        loans payable, net of current portion
      		                                       2,701,000 3,154,000 3,601,000 4,036,000 3,404,000 
        deferred licensing revenue, net of current portion
      		                                     35,000 42,000 49,000 56,000 64,000 71,000 78,000 
        preferred stock, 0.001 par value...
      		                                            
        loans payable
      		                                       1,950,000 1,455,000 965,000 480,000 1,075,000 
        deferred public offering costs
      		                                           2,846,000 
        liabilities, convertible preferred stock and stockholders’ equity
      		                                            
        convertible promissory notes
      		                                           5,524,000 
        derivative liability
      		                                           2,287,000 
        preferred stock warrant liability
      		                                           349,000 
        deferred rent, net of current portion
      		                                           2,000 
        convertible preferred stock, 0.001 par value...
      		                                           39,556,000 
        total liabilities, convertible preferred stock and stockholders’ equity
      		                                        56,791,000 62,079,000 67,598,000  
        liabilities, convertible preferred stock and stockholders’ deficit
      		                                            
        stockholders’ deficit
      		                                            
        total liabilities, convertible preferred stock and stockholders’ deficit
      		                                           7,712,000 
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2026-03-31 2025-07-31 2025-04-30 2025-01-31 2024-10-31 2024-07-31 2024-04-30 2024-01-31 2023-10-31 2023-07-31 2023-04-30 2023-01-31 2022-10-31 2022-07-31 2022-04-30 2022-01-31 2021-10-31 2021-07-31 2021-04-30 2021-01-31 2020-10-31 2020-07-31 2020-04-30 2020-01-31 2019-10-31 2019-07-31 2019-04-30 2019-01-31 2018-10-31 2018-07-31 2018-04-30 2018-01-31 2017-10-31 2017-07-31 2017-04-30 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 
                                                  
          cash flows from operating activities:
        		                                          
          net loss
        		-23,487,000 -60,096,000 -52,226,000 -48,508,000 -42,267,000 -40,443,000 -44,649,000 -29,028,000 -27,650,000 -25,317,000 -26,305,000 -21,303,000 -22,257,000 -23,042,000 -24,113,000 -22,468,000 -19,649,000 -16,109,000 -14,956,000 -10,047,000 -10,427,000 -10,814,000 -6,584,000 -9,291,000 -5,903,000 -7,338,000 -8,526,000 -3,956,000 -3,304,000 -5,030,000 -657,000 -5,234,000 -4,986,000 -4,928,000 -4,202,000 -2,386,000 -7,349,000 -6,607,000 -5,659,000 -4,991,000 -9,012,000 -5,184,000 
          adjustments to reconcile net loss to net cash from operating activities:
        		                                          
          depreciation and amortization
        		355,000 252,000 261,000 229,000 227,000 224,000 219,000 207,000 197,000 193,000 188,000 199,000 173,000 158,000 156,000 149,000 127,000 132,000 140,000 136,000 133,000 128,000 130,000 134,000 127,000 121,000 122,000 103,000 103,000 50,000 51,000 50,000 47,000 32,000  0 0 34,000 35,000 33,000 34,000 31,000 
          stock-based compensation expense
        		5,068,000 5,379,000 3,642,000 2,610,000 2,999,000 3,040,000 12,743,000 2,711,000 3,207,000 3,254,000 2,441,000 2,333,000 2,506,000 2,642,000 2,654,000 2,777,000 2,860,000 2,795,000 3,441,000 1,241,000 1,248,000 1,188,000 1,090,000 1,122,000 1,162,000 1,074,000 846,000 797,000 976,000 347,000             
          realized loss from sale of marketable securities
        		11,000      -195,000 -221,000 -595,000 -314,000 55,000 -1,000 69,000 16,000 285,000 176,000 97,000 23,000                         
          non-cash operating lease expense
        		158,000 218,000   -45,000 -5,000 -1,000 2,000 -19,000 6,000 32,000 10,000 19,000 23,000 26,000 107,000 24,000 22,000 89,000 8,000 9,000 8,000                     
          accretion of discount on marketable securities
        		-100,000                                          
          foreign currency exchange loss
        		1,687,000 485,000 -8,190,000 4,554,000   164,000 -215,000 1,206,000 -395,000 -279,000 -600,000 -1,165,000 426,000 854,000 432,000 252,000 14,000 -133,000 -273,000 264,000 -432,000                     
          non-cash interest expense and amortization of issuance costs
        		4,432,000 3,453,000 2,948,000                                        
          fair value adjustment to derivative liability
        		1,605,000 1,100,000 1,600,000                                        
          changes in operating assets and liabilities:
        		                                          
          research and development tax credit receivable
        		-1,355,000 826,000   -1,068,000 -1,253,000 14,391,000 -2,106,000 -2,025,000 -2,084,000 -4,365,000 9,186,000 -3,567,000 -3,570,000 -3,724,000 5,775,000 -4,041,000 -3,211,000 -2,678,000 7,813,000 -2,140,000 4,462,000 -2,376,000 -2,828,000 1,483,000 -2,060,000 -2,474,000 -1,717,000 -1,611,000 919,000 -1,873,000 -986,000 -867,000 -530,000 703,000        
          accounts receivable
        		-7,322,000 -1,926,000                                         
          inventory
        		-665,000                                          
          prepaid expenses and other assets
        		-184,000 1,597,000 -1,281,000 -1,398,000 2,104,000 -783,000 -1,444,000 145,000 1,764,000 -1,003,000 2,250,000 790,000 1,715,000 1,935,000 -5,621,000 -1,240,000                           
          accounts payable
        		-149,000 2,510,000 -1,392,000 779,000 -5,860,000 1,502,000 6,098,000 -1,941,000 55,000 108,000 3,018,000 -1,830,000 597,000 -678,000 1,459,000 -935,000 1,691,000 -528,000 1,332,000 -1,628,000 411,000 35,000 -1,137,000 691,000 -950,000 392,000 -214,000 -340,000 962,000 1,126,000 -331,000 687,000 -910,000 771,000 358,000 244,000 -1,001,000 -272,000 -148,000 -290,000 -218,000 1,011,000 
          accrued expenses and other liabilities
        		-5,220,000                                          
          deferred revenue
        		10,711,000 493,000                     -3,824,000 -1,577,000 -3,920,000 -3,369,000 -2,926,000 -3,890,000 -5,593,000 -3,718,000 -4,573,000            
          net cash from operating activities
        		-14,455,000 -54,502,000 -40,364,000 -32,681,000 -39,642,000 -40,220,000 -15,105,000 -27,571,000 -19,825,000 -26,730,000 -22,636,000 -9,289,000 -20,594,000 -22,742,000 -26,789,000 -14,065,000 -19,545,000 -17,735,000 -11,045,000 -7,586,000 -7,952,000 -3,588,000 -12,618,000 -13,109,000 -7,814,000 -11,275,000 -10,511,000 -10,856,000 -8,786,000 -6,212,000 -5,955,000 28,220,000 -7,259,000 -4,448,000 -2,641,000 -1,616,000 -7,260,000 -5,084,000 -5,067,000 -5,306,000 -6,441,000 -4,049,000 
          capital expenditures
        		-121,000 -290,000 -281,000 -24,000 -108,000 -21,000 -15,000 -19,000 -2,000 -6,000 -69,000 -15,000 -192,000 -920,000 -86,000 -202,000 -356,000 -287,000 -33,000 -14,000 -13,000  -8,000 0 -114,000 -51,000 -275,000 -20,000 -221,000 -465,000 -1,084,000 -182,000 -51,000 -110,000 0 0 -61,000 -184,000 -379,000 -21,000 -79,000 -180,000 
          free cash flows
        		-14,576,000 -54,792,000 -40,645,000 -32,705,000 -39,750,000 -40,241,000 -15,120,000 -27,590,000 -19,827,000 -26,736,000 -22,705,000 -9,304,000 -20,786,000 -23,662,000 -26,875,000 -14,267,000 -19,901,000 -18,022,000 -11,078,000 -7,600,000 -7,965,000  -12,626,000 -13,109,000 -7,928,000 -11,326,000 -10,786,000 -10,876,000 -9,007,000 -6,677,000 -7,039,000 28,038,000 -7,310,000 -4,558,000 -2,641,000 -1,616,000 -7,321,000 -5,268,000 -5,446,000 -5,327,000 -6,520,000 -4,229,000 
          cash flows from investing activities:
        		                                          
          purchases of marketable securities
        		-16,428,000 -19,979,000  -6,563,000 -1,000 -983,000  -18,150,000 -3,770,000 -25,767,000  -53,655,000 0 -10,102,000  -32,720,000 -32,659,000 -19,036,000  -7,472,000 -9,535,000 -9,807,000                     
          sales and maturities of marketable securities
        		15,730,000 41,677,000  15,207,000 48,876,000 38,230,000  11,558,000 32,531,000 45,386,000  51,153,000 20,290,000 41,066,000  45,824,000 50,658,000 34,204,000  14,431,000 15,919,000 15,342,000                     
          acquisition of property and equipment
        		-121,000 -290,000 -281,000 -24,000 -108,000 -21,000 -15,000 -19,000 -2,000 -6,000 -69,000 -15,000 -192,000 -920,000 -86,000 -202,000 -356,000 -287,000 -33,000 -14,000 -13,000 -22,000 -8,000 0 -114,000 -98,000 -275,000 -20,000 -221,000 -565,000 -1,084,000 -182,000 -51,000 -110,000         
          capitalized website development costs
        		-82,000 -147,000 -234,000 -103,000 -94,000 -64,000                                     
          net cash from investing activities
        		-901,000 21,261,000 -3,328,000 8,517,000 48,673,000 37,162,000 -126,186,000 -6,702,000 28,556,000 19,613,000 -6,210,000 -2,517,000 20,098,000 30,044,000 12,434,000 12,902,000 17,643,000 14,881,000 -166,483,000 6,945,000 6,371,000 5,513,000 10,027,000 9,770,000 -1,514,000 -1,530,000 -14,047,000 -54,589,000 -221,000 -565,000 -1,084,000 -182,000 -51,000 -110,000 -7,000 0 122,000 -184,000 -1,094,000 -21,000 -79,000 -180,000 
          cash flows from financing activities:
        		                                          
          issuance of common stock from equity incentive plans
        		793,000 595,000 1,849,000 632,000 295,000 3,000,000 30,000 284,000 128,000 204,000 -33,000 146,000 168,000 168,000 138,000 772,000 63,000 608,000 1,374,000 55,000 60,000 46,000 2,000 44,000 138,000 32,000                 
          issuance of common stock from employee stock purchase plan
        		672,000 694,000                                         
          net cash from financing activities
        		1,465,000 23,210,000 4,659,000 151,773,000 295,000 3,000,000 150,098,000 284,000 128,000 204,000 -33,000 57,813,000 168,000 168,000 138,000 772,000 63,000 608,000 210,308,000 1,703,000 60,000 46,000 1,000 45,000 138,000 11,400,000 155,000 56,000 82,784,000 4,948,000 -13,000 -52,000   0 5,000   6,000 -176,000 68,720,000 3,513,000 
          effect of exchange rate changes
        		-1,683,000                                          
          net decrease in cash, cash equivalents and restricted cash
        		-15,574,000                                          
          cash, cash equivalents and restricted cash at beginning of the period
        		230,145,000                                          
          cash, cash equivalents and restricted cash at end of the period
        		214,571,000                                          
          less: restricted cash in other assets
        		803,000                                          
          cash and cash equivalents
        		213,768,000 124,304,000                                         
          supplemental disclosure of cash flow information
        		                                          
          cash paid for interest
        		2,123,000                                   0 561,000 45,000 135,000 0 1,000 44,000 
          supplemental disclosure of non-cash activities
        		                                          
          property and equipment included in accounts payable and accrued expenses
        		                                          
          website development costs included in accrued expenses
        		91,000                                          
          realized gain from sale of marketable securities
        		 -587,000                 39,000 -76,000 -46,000 -70,000                     
          non cash operating lease expense
        		                                          
          amortization of premium on marketable securities
        		 -7,000  1,000 5,000 5,000  5,000 21,000 62,000  212,000 287,000 391,000  657,000 671,000 753,000  110,000 69,000 68,000                     
          impairment of right of use assets
        		                                          
          disposal of property and equipment
        		                                          
          proceeds from sale of convertible notes
        		                                          
          proceeds from the royalty agreement
        		 21,921,000                                         
          issuance of common stock, net of issuance costs of 0.5 million
        		                                          
          issuance of pre-funded warrants
        		                                          
          net increase in cash, cash equivalents and restricted cash
        		 -7,308,000                                         
          lease liabilities arising from obtaining right of use assets
        		                                          
          accrued debt issuance costs
        		                                          
          cash flows from operating activities
        		                                          
          accrued expenses
        		 -8,199,000 8,115,000 3,053,000 5,037,000 -1,776,000 -2,435,000 2,870,000 4,014,000 -1,240,000 231,000 1,715,000 1,029,000 -1,043,000 751,000 505,000 217,000 -1,001,000 1,522,000 -1,874,000 797,000 538,000 718,000 -202,000 553,000 -1,117,000 2,248,000 351,000 -91,000 157,000 800,000 -33,000 550,000 -185,000 -371,000 -282,000 632,000 -246,000 37,000 -394,000   
          cash flows from investing activities
        		                                          
          cash flows from financing activities
        		                                          
          effect of exchange rate changes on cash and cash equivalents
        		 2,723,000 3,364,000 -1,249,000 407,000 117,000 -74,000 -621,000 -602,000 84,000 68,000 457,000 1,050,000 -339,000 -628,000 -523,000 -13,000 -3,000 85,000 491,000 -319,000 254,000 -236,000 190,000 802,000 -494,000 64,000 618,000 -731,000 -1,156,000             
          cash, cash equivalents and restricted cash at beginning of period
        		 132,272,000                                         
          cash, cash equivalents and restricted cash at end of period
        		 124,964,000                                         
          supplemental disclosures of non-cash activities:
        		                                          
          right of use assets obtained in exchange for operating lease liabilities
        		 725,000 458,000 0       0 0 0 1,192,000 0                            
          reconciliation of cash, cash equivalents and restricted cash:
        		                                          
          restricted cash, long-term
        		 660,000                                         
          total cash, cash equivalents and restricted cash
        		 124,964,000                                         
          amortization of premium on available for sale securities
        		                                          
          other receivables
        		                                          
          purchases of available for sale securities
        		                      -4,683,000 -2,553,000 -22,915,000 -19,646,000 -24,470,000                
          sales and maturities of available for sale securities
        		                      14,718,000 12,323,000 21,515,000 18,214,000                 
          issuance costs associated with the royalty agreement
        		                                          
          issuance of common stock, net of offering expenses
        		  0                208,934,000    0     0               
          net increase in cash and cash equivalents
        		  -35,669,000 126,360,000 9,733,000 59,000 8,733,000 -34,610,000 8,257,000 -6,829,000 -28,811,000 46,464,000 722,000 7,131,000 -14,845,000 -914,000 -1,852,000 -2,249,000 32,865,000 1,553,000 -1,840,000 2,225,000 -2,826,000 -3,104,000   -24,339,000 -64,771,000   -7,623,000    -2,548,000 -1,611,000   -6,155,000 -5,503,000   
          cash and cash equivalents and restricted cash at beginning of year
        		                                          
          cash and cash equivalents and restricted cash at end of year
        		                                          
          supplemental disclosures of cash flow information:
        		                                          
          website development costs included in accounts payable
        		                                          
          non-cash operating lease benefit
        		                                          
          research and development tax credit
        		                                          
          proceeds from royalty agreement
        		                                          
          issuance costs associated with royalty agreement
        		                                          
          realized (gain) from sale of marketable securities
        		    -649,000 -317,000                                     
          cash and cash equivalents at beginning of period
        		    0 31,789,000  0 0 56,238,000  0 0 30,732,000  0 0 50,592,000  0 0 15,789,000  0 0 32,006,000  0 0 51,055,000  0 0 30,950,000  0 0 53,723,000  0 0 3,897,000 
          cash and cash equivalents at end of period
        		    9,733,000 31,848,000  -34,610,000 8,257,000 49,409,000  46,464,000 722,000 37,863,000  -914,000 -1,852,000 48,343,000  1,553,000 -1,840,000 18,014,000  -3,104,000 -8,388,000 30,107,000  -64,771,000 73,046,000 48,070,000  30,550,000 1,672,000 26,456,000  -1,611,000 -11,636,000 48,455,000  -5,503,000 62,200,000 3,181,000 
          foreign currency exchange
        		     -414,000                                     
          cash and cash equivalents, beginning year
        		                                          
          cash and cash equivalents, end of year
        		                                          
          website development costs
        		       -91,000                                   
          issuance of common stock, net of offering expenses of 0.3 million
        		                                          
          issuance of pre-funded warrants, net of offering expenses
        		                                          
          property and equipment included in accounts payable and accrued expenses:
        		            -12,000 144,000  -20,000                           
          finance lease principal payments
        		                                          
          prepaid expenses and other current assets
        		                 -625,000 -257,000 -2,996,000 1,730,000 1,301,000 -925,000 -972,000 224,000 561,000 496,000 -1,958,000 -448,000 -69,000 460,000 -570,000 -551,000 -85,000 608,000 533,000 327,000 85,000 349,000 43,000 -487,000 -437,000 
          other assets
        		                              0     0 0 59,000 -58,000    
          acquisition of property and equipment in accounts payable
        		                         47,000    100,000             
          grants and other receivables
        		                              38,000 871,000           
          capital leases
        		                              0 0 0 513,000         
          realized (gain) from available for sale securities
        		                                          
          amortization of right of use assets
        		                       145,000 135,000 138,000                 
          amortization of discount/premium on available for sale securities
        		                       57,000 44,000 35,000                 
          foreign currency exchange gain
        		                                          
          lease obligations
        		                       -145,000 -134,000 -137,000                 
          capital lease principal payments
        		                       1,000 0 -54,000 -54,000 -51,000 -52,000 -52,000 -50,000 -52,000           
          realized loss from available for sale securities
        		                        -100,000 -29,000                 
          foreign currency remeasurement loss
        		                        -535,000 454,000 -60,000 -246,000 220,000 6,000 -151,000 -531,000 -1,000 32,000         
          issuance of common stock, net of 123 of offering expenses
        		                        0 11,422,000                 
          net decrease in cash and cash equivalents
        		                         -1,899,000    -2,985,000   1,672,000 -4,494,000    -5,268,000    -716,000 
          supplemental disclosures of non-cash financing activities
        		                                          
          changes in operating assets and liabilities, net of changes from business acquired:
        		                                          
          cash acquired in transaction
        		                                          
          proceeds from issuance of common stock, net of issuance costs of 4,390 in the year ended april 30, 2019
        		                                          
          proceeds from issuance of common stock from exercise of stock options
        		                                          
          conversion of preferred stock and ordinary shares to common stock
        		                                          
          sales of available for sale securities
        		                                          
          issuance of common stock from stock option exercises
        		                           107,000               
          issuance of common stock
        		                             5,000,000  0           
          proceeds from issuance of common stock
        		                                  0    0 -176,000 67,964,000 120,000 
          proceeds from issuance of series b preferred stock, net of issuance costs
        		                                          
          stock-based compensation
        		                               285,000 273,000 221,000         
          effect of exchange rate changes on cash
        		                               2,564,000 -69,000 64,000 100,000        
          conversion of preferred stock to common stock
        		                                      0 0   
          due to related parties
        		                                          
          grants receivable
        		                                 224,000 -7,000        
          depreciation expense
        		                                          
          share-based compensation expense
        		                                          
          foreign currency exchange rate gain
        		                                          
          cash acquired in carbylan transaction
        		                                          
          purchases of property and equipment
        		                                          
          proceeds from issuance of series a preferred stock, net of issuance costs
        		                                          
          cash paid for taxes
        		                                          
          foreign currency remeasurement gain
        		                                          
          proceeds from issuance of redeemable convertible preferred stock
        		                                          
          gain on sale of property and equipment
        		                                   0       
          stock based compensation expense
        		                                   282,000 312,000 368,000  289,000 37,000 118,000 
          change in fair value of preferred stock warrant liability and derivative liability
        		                                      0 0 -2,000 -518,000 
          non-cash interest expense
        		                                   0 23,000 35,000 37,000 35,000 73,000 84,000 
          amortization of loan and convertible promissory notes discount
        		                                   0 76,000 7,000 7,000 15,000 51,000 707,000 
          loss on extinguishment of loans payable
        		                                          
          loss on extinguishment of convertible promissory notes
        		                                      0 0   
          impairment of long-lived assets
        		                                   0 0 1,460,000     
          deferred licensing revenue
        		                                   -7,000 -7,000 -7,000 -8,000 -7,000 -7,000 -7,000 
          purchase of property and equipment
        		                                   0 -61,000 -184,000 -379,000 -21,000 -79,000 -180,000 
          sale of property and equipment
        		                                   0       
          proceeds from issuance of common stock upon exercise of options
        		                                   5,000   6,000 0   
          proceeds from convertible promissory notes
        		                                        0 4,000,000 
          repayment of loan payable
        		                                   0       
          supplemental cash flow information
        		                                          
          supplemental disclosures of non-cash investing activities
        		                                          
          transfer of long-term deposits to property and equipment
        		                                   0 0 824,000     
          conversion of preferred stock warrants to common stock warrants
        		                                      0 0   
          derivative related to convertible promissory notes at issuance
        		                                          
          beneficial conversion feature for convertible promissory notes
        		                                          
          loss on extinguishment of loan payable
        		                                          
          increase accrual of deferred public offering costs
        		                                          
          deferred public offering costs
        		                                         -607,000 
          property and equipment additions in accounts payable and accrued expenses
        		                                     61,000     
          accrual of deferred public offering costs
        		                                          
          stock based compensation
        		                                          
          deposit for leasehold improvements
        		                                          
          proceeds from issuance of convertible preferred stock
        		                                          
          proceeds from loans payable
        		                                          
          repayment of loans payable
        		                                          
          cash and cash equivalents at beginning of year
        		                                          
          cash and cash equivalents at end of year
        		                                          
          issuance of preferred stock warrants
        		                                          
          increase of accrual for deferred public offering costs
        		                                          
          increase of derivative related to convertible promissory notes
        		                                          
          increase of beneficial conversion feature for convertible promissory notes
        		                                      0 0   
          increase of derivative related to convertible promissory notes at issuance
        		                                       0   
          accruals
        		                                         146,000 
          derivative related to convertible promissory notes upon issuance
        		                                         1,196,000 
          beneficial conversion feature of convertible promissory notes
        		                                         158,000