Disc Medicine Inc.(NASDAQ:IRON)

Disc Medicine, Inc., a clinical-stage biotechnology company, engages in discovery, development, and commercialization of novel treatments for patients suffering from serious hematologic diseases. The company is headquartered in Watertown, Massachusetts.
Website: https://www.discmedicine.com/
Founded: 2017
CEO: John Quisel
Sector: Healthcare
Industry: Biotechnology
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At a glance:
Bull Thesis:
Bear Thesis:
Main Competitors:
Moat:
Income Statements:
Quarterly
Annual
| Unit: USD | 2026-03-31 | 2025-12-31 | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-09-30 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
operating expenses: | ||||||||||||||||||||||
research and development | 45,904,000 | 46,224,000 | 50,334,000 | 46,319,000 | 27,763,000 | 24,797,000 | 24,685,000 | 23,485,000 | 23,704,000 | 22,565,000 | 14,419,000 | 12,100,000 | 20,180,000 | 20,615,000 | 438,000 | 2,580,000 | 9,804,000 | 12,634,000 | 13,455,000 | 10,842,000 | 11,786,000 | |
selling, general and administrative | 23,620,000 | 20,746,000 | 17,362,000 | 15,091,000 | 12,183,000 | |||||||||||||||||
total operating expenses | 69,524,000 | 66,970,000 | 67,696,000 | 61,410,000 | 39,946,000 | 34,550,000 | 32,856,000 | 30,852,000 | 31,462,000 | 29,714,000 | 18,958,000 | 17,328,000 | 25,125,000 | 21,327,000 | 3,737,000 | 7,234,000 | 15,177,000 | 17,742,000 | 18,450,000 | 16,320,000 | 16,490,000 | |
income from operations | -69,524,000 | -66,970,000 | -67,696,000 | -61,410,000 | -39,946,000 | -34,550,000 | -32,856,000 | -30,852,000 | -31,462,000 | -29,714,000 | -18,958,000 | -17,328,000 | -25,125,000 | -21,327,000 | -3,737,000 | -7,234,000 | -15,177,000 | -17,742,000 | -18,450,000 | -16,320,000 | -16,490,000 | -500,900 |
yoy | 74.04% | 93.84% | 106.04% | 99.05% | 26.97% | 16.28% | 73.31% | 78.05% | 25.22% | 39.33% | 407.31% | 139.54% | 65.55% | 20.21% | -79.75% | -55.67% | -7.96% | 3442.02% | ||||
qoq | 3.81% | -1.07% | 10.24% | 53.73% | 15.62% | 5.16% | 6.50% | -1.94% | 5.88% | 56.74% | 9.41% | -31.03% | 17.81% | 470.70% | -48.34% | -52.34% | -14.46% | -3.84% | 13.05% | -1.03% | 3192.07% | |
other income, net: | ||||||||||||||||||||||
interest income | 6,893,000 | 7,412,000 | 6,412,000 | 7,057,000 | 6,880,000 | 5,838,000 | 6,362,000 | 4,573,000 | 4,519,000 | 4,677,000 | 4,843,000 | 2,910,000 | 2,367,000 | 52,000 | 499,000 | 149,000 | 9,000 | 4,000 | 5,000 | 5,000 | 1,000 | |
interest expense | -844,000 | -883,000 | -917,000 | -910,000 | -897,000 | -38,750 | -41,000 | -48,000 | -66,000 | -85,000 | -104,000 | -121,000 | -1,848,000 | |||||||||
other income | 22,000 | -2,000 | -18,000 | 68,000 | -1,250 | 9,000 | 12,000 | 2,000 | 43,000 | 3,000 | ||||||||||||
total other income | 6,071,000 | 6,527,000 | 5,477,000 | 6,215,000 | 5,980,000 | 5,269,000 | 6,371,000 | 4,560,000 | 4,518,000 | 6,167,000 | 4,856,000 | 1,405,000 | 2,367,000 | |||||||||
income before income taxes | -63,453,000 | -60,443,000 | -62,219,000 | -55,195,000 | -33,966,000 | -29,281,000 | -26,485,000 | -26,292,000 | -26,944,000 | -23,547,000 | -14,102,000 | -15,923,000 | -22,758,000 | |||||||||
income tax expense | -51,000 | -88,000 | -102,000 | -52,000 | -119,000 | -176,000 | -114,000 | -60,000 | -5,000 | -32,000 | -20,000 | -24,000 | -23,000 | |||||||||
net income | -63,504,000 | -60,531,000 | -62,321,000 | -55,247,000 | -34,085,000 | -29,457,000 | -26,599,000 | -26,352,000 | -499,411 | |||||||||||||
yoy | 86.31% | 105.49% | 134.30% | 109.65% | ||||||||||||||||||
qoq | 4.91% | -2.87% | 12.80% | 62.09% | 15.71% | 10.74% | 0.94% | |||||||||||||||
net income per share | -1.65 | -1.62 | -1.77 | -1.58 | -1.02 | -0.98 | -0.89 | -1.03 | -1.09 | -0.97 | -0.58 | -0.74 | -1.2 | -44.46 | -0.08 | -0.16 | -0.35 | -0.41 | -0.43 | -0.38 | -0.59 | |
weighted-average common shares outstanding, basic and diluted | 38,491,433 | 35,295,663 | 35,178,691 | 35,024,592 | 33,324,745 | 27,606,022 | 43,264,616 | 43,230,523 | 43,212,803 | 40,362,303 | 43,091,822 | 43,041,856 | 32,027,161 | |||||||||
comprehensive loss: | ||||||||||||||||||||||
other comprehensive income: | ||||||||||||||||||||||
foreign currency translation adjustments | -10 | -15 | 14 | 15 | -48 | 6 | ||||||||||||||||
unrealized gain on marketable securities | -1,526 | 247 | 445 | 232 | -467 | 849 | ||||||||||||||||
total other comprehensive income | -1,536 | 247 | 445 | 246 | -452 | 801 | ||||||||||||||||
comprehensive loss | -65,040 | -60,284 | -61,876 | -55,509 | -33,839 | -29,909 | -25,798 | -26,412 | ||||||||||||||
unrealized loss on marketable securities | -247 | -66 | ||||||||||||||||||||
total other comprehensive loss | -262 | -60 | ||||||||||||||||||||
other expense | -3,000 | -13,000 | -1,000 | -10,000 | 13,000 | -5,000 | -2,000 | -11,000 | ||||||||||||||
general and administrative | 5,824,000 | 8,171,000 | 7,367,000 | 7,758,000 | 7,149,000 | 4,539,000 | 5,228,000 | 4,945,000 | 712,000 | 3,299,000 | 4,654,000 | 5,373,000 | 5,108,000 | 4,995,000 | 5,478,000 | 4,704,000 | ||||||
change in fair value of contingent value right liability | -375,000 | -1,500,000 | ||||||||||||||||||||
net loss attributable to common stockholders-basic and diluted | -19,975,000 | -26,599,000 | -26,352,000 | -26,949,000 | -23,579,000 | -14,122,000 | -15,947,000 | -22,781,000 | ||||||||||||||
weighted-average common shares outstanding-basic and diluted | 29,935,551,000 | 25,649,043,000 | 24,809,869,000 | 22,315,877,000 | 24,316,817,000 | 21,484,955,000 | 18,954,914,000 | 1,039,490,000 | ||||||||||||||
other comprehensive loss: | ||||||||||||||||||||||
net loss and comprehensive loss | -26,949,000 | -23,579,000 | -14,122,000 | -15,947,000 | -22,781,000 | -21,229,000 | -3,277,000 | -7,090,000 | -15,231,000 | -17,823,000 | -18,551,000 | -16,447,000 | -19,048,000 | |||||||||
change in fair value of derivative liability | ||||||||||||||||||||||
other income: | ||||||||||||||||||||||
loss on conversion of convertible notes | -711,000 | |||||||||||||||||||||
change in fair value of warrant liability | ||||||||||||||||||||||
net loss attributable to common stockholders | -16,447,000 | -19,048,000 | ||||||||||||||||||||
general and administrative expenses | 450,986 | |||||||||||||||||||||
franchise tax expense | 49,914 | |||||||||||||||||||||
interest earned on cash equivalents held in trust account | 1,489 | |||||||||||||||||||||
loss before income tax expense | -499,411 | |||||||||||||||||||||
income tax benefit | ||||||||||||||||||||||
weighted-average shares outstanding of class a common stock | 12,516,500 | |||||||||||||||||||||
basic and diluted net income per share, class a | ||||||||||||||||||||||
weighted-average shares outstanding of class b common stock | 3,018,750 | |||||||||||||||||||||
basic and diluted net loss per share, class b | -0.17 |
Balance Sheets:
Quarterly
Annual
| Unit: USD | 2026-03-31 | 2025-12-31 | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
assets | |||||||||||||||||||||
current assets: | |||||||||||||||||||||
cash and cash equivalents | 88,913,000 | 91,145,000 | 140,664,000 | 127,337,000 | 122,675,000 | 192,434,000 | 192,638,000 | 280,663,000 | 342,615,000 | 360,382,000 | 370,541,000 | 377,602,000 | 236,422,000 | 194,611,000 | 101,737,000 | 108,659,000 | 119,064,000 | 136,627,000 | 150,069,000 | 167,477,000 | 184,986,000 |
marketable securities | 641,245,000 | 700,007,000 | 475,256,000 | 522,636,000 | 571,987,000 | 297,447,000 | 294,725,000 | 220,282,000 | |||||||||||||
prepaid expenses and other current assets | 17,297,000 | 12,746,000 | 11,248,000 | 11,619,000 | 10,938,000 | 3,734,000 | 5,789,000 | 7,296,000 | 9,333,000 | 5,280,000 | 3,722,000 | 4,131,000 | 5,716,000 | 3,880,000 | 2,927,000 | 4,470,000 | 4,681,000 | 3,250,000 | 4,731,000 | 3,834,000 | 3,619,000 |
total current assets | 747,455,000 | 803,898,000 | 627,168,000 | 661,592,000 | 705,600,000 | 493,615,000 | 493,152,000 | 508,241,000 | 351,948,000 | 365,662,000 | 374,263,000 | 381,733,000 | 242,138,000 | 198,491,000 | 104,664,000 | 113,129,000 | 124,068,000 | 140,100,000 | 154,800,000 | 171,311,000 | 188,605,000 |
property and equipment | 1,070,000 | 1,159,000 | 1,228,000 | 1,289,000 | 1,370,000 | 751,000 | 79,000 | 98,000 | 211,000 | 170,000 | 183,000 | 159,000 | 180,000 | 168,000 | 180,000 | 229,000 | 229,000 | ||||
right-of-use assets, operating leases | 967,000 | 1,096,000 | 1,220,000 | 1,340,000 | 1,457,000 | 1,569,000 | 1,678,000 | 1,642,000 | 1,788,000 | 1,930,000 | 1,935,000 | 2,166,000 | 1,346,000 | 1,430,000 | |||||||
other assets | 721,000 | 726,000 | 840,000 | 840,000 | 839,000 | 838,000 | 236,000 | 236,000 | 235,000 | 234,000 | 116,000 | 116,000 | 116,000 | 116,000 | 1,367,000 | 204,000 | 217,000 | 237,000 | 232,000 | 559,000 | 225,000 |
total assets | 750,213,000 | 806,879,000 | 630,456,000 | 665,061,000 | 709,266,000 | 496,773,000 | 495,145,000 | 510,217,000 | 354,182,000 | 367,996,000 | 376,497,000 | 384,174,000 | 243,780,000 | 200,205,000 | 106,031,000 | 113,333,000 | 124,285,000 | 140,437,000 | 155,535,000 | 172,422,000 | 189,382,000 |
liabilities and stockholders’ equity | |||||||||||||||||||||
current liabilities: | |||||||||||||||||||||
accounts payable | 11,759,000 | 9,018,000 | 7,268,000 | 6,350,000 | 6,703,000 | 7,948,000 | 3,553,000 | 4,749,000 | 5,269,000 | 12,629,000 | 8,496,000 | 5,214,000 | 5,642,000 | 16,162,000 | 1,139,000 | 1,618,000 | 5,110,000 | 2,950,000 | 939,000 | 1,492,000 | 3,562,000 |
accrued external research and development expenses | 12,137,000 | 11,451,000 | 7,705,000 | 7,463,000 | 7,421,000 | 7,141,000 | 16,332,000 | 10,351,000 | |||||||||||||
other accrued expenses | 6,827,000 | 15,561,000 | 11,115,000 | 6,161,000 | 4,138,000 | 8,097,000 | 5,512,000 | 4,451,000 | |||||||||||||
operating lease liabilities, current | 419,000 | 611,000 | 656,000 | 632,000 | 479,000 | 130,000 | 76,000 | 759,000 | 767,000 | 665,000 | 353,000 | 321,000 | 313,000 | 307,000 | |||||||
total current liabilities | 31,142,000 | 36,641,000 | 26,744,000 | 20,606,000 | 18,741,000 | 23,316,000 | 25,473,000 | 20,310,000 | 14,852,000 | 21,439,000 | 14,416,000 | 9,683,000 | 9,980,000 | 22,578,000 | 1,464,000 | 6,436,000 | 12,674,000 | 14,834,000 | 12,661,000 | 11,505,000 | 13,776,000 |
long-term debt | 29,365,000 | 29,159,000 | 28,948,000 | 28,737,000 | 28,529,000 | 28,322,000 | |||||||||||||||
operating lease liabilities, non-current | 1,277,000 | 1,253,000 | 1,373,000 | 1,553,000 | 1,634,000 | 1,548,000 | 1,712,000 | 1,078,000 | 1,259,000 | 1,436,000 | 1,607,000 | 1,772,000 | 945,000 | 1,027,000 | |||||||
total liabilities | 61,784,000 | 67,053,000 | 57,065,000 | 50,896,000 | 48,904,000 | 53,186,000 | 27,185,000 | 21,388,000 | 16,111,000 | 22,875,000 | 17,523,000 | 12,955,000 | 10,925,000 | 23,605,000 | 1,464,000 | 6,436,000 | 12,674,000 | 15,596,000 | 14,674,000 | 14,740,000 | 18,221,000 |
commitments and contingencies | |||||||||||||||||||||
stockholders’ equity: | |||||||||||||||||||||
preferred stock, 0.0001 par value... | |||||||||||||||||||||
common stock, 0.0001 par value... | 4,000 | 4,000 | 4,000 | 3,000 | 3,000 | 3,000 | 3,000 | 3,000 | 2,000 | 2,000 | 2,000 | 2,000 | 2,000 | 2,000 | 4,000 | 4,000 | 4,000 | 4,000 | 4,000 | 4,000 | 4,000 |
additional paid-in capital | 1,262,686,000 | 1,249,043,000 | 1,022,324,000 | 1,001,223,000 | 991,911,000 | 741,297,000 | 735,761,000 | 730,832,000 | 553,663,000 | 533,764,000 | 524,038,000 | 522,161,000 | 367,850,000 | 288,814,000 | 314,851,000 | 313,904,000 | 311,528,000 | 309,527,000 | 307,724,000 | 305,994,000 | 303,026,000 |
accumulated other comprehensive income | -571,000 | 965,000 | 718,000 | 273,000 | 535,000 | 289,000 | 741,000 | ||||||||||||||
accumulated deficit | -573,690,000 | -510,186,000 | -449,655,000 | -387,334,000 | -332,087,000 | -298,002,000 | -268,545,000 | -241,946,000 | -215,594,000 | -188,645,000 | -165,066,000 | -150,944,000 | -134,997,000 | -112,216,000 | -210,288,000 | -207,011,000 | -199,921,000 | -184,690,000 | -166,867,000 | -148,316,000 | -131,869,000 |
total stockholders’ equity | 688,429,000 | 739,826,000 | 573,391,000 | 614,165,000 | 660,362,000 | 443,587,000 | 467,960,000 | 488,829,000 | 338,071,000 | 345,121,000 | 358,974,000 | 371,219,000 | 232,855,000 | 176,600,000 | 124,841,000 | ||||||
total liabilities and stockholders’ equity | 750,213,000 | 806,879,000 | 630,456,000 | 665,061,000 | 709,266,000 | 496,773,000 | 495,145,000 | 510,217,000 | 354,182,000 | 367,996,000 | 376,497,000 | 384,174,000 | 243,780,000 | 140,437,000 | |||||||
accumulated other comprehensive loss | -60,000 | ||||||||||||||||||||
accrued expenses | 8,816,000 | 8,145,000 | 5,567,000 | 4,148,000 | 4,025,000 | 6,109,000 | |||||||||||||||
contingent value right liability | 1,500,000 | 1,500,000 | |||||||||||||||||||
liabilities, convertible preferred stock and stockholders’ equity | |||||||||||||||||||||
derivative liability | |||||||||||||||||||||
series seed convertible preferred stock, 0.0001 par value... | |||||||||||||||||||||
series a convertible preferred stock, 0.0001 par value... | |||||||||||||||||||||
series b convertible preferred stock, 0.0001 par value... | |||||||||||||||||||||
stockholders’ equity | |||||||||||||||||||||
total liabilities, convertible preferred stock and stockholders’ equity | 200,205,000 | ||||||||||||||||||||
restricted cash, current | 323,000 | 223,000 | |||||||||||||||||||
restricted cash, non-current | 100,000 | ||||||||||||||||||||
liabilities and stockholders' equity | |||||||||||||||||||||
accrued expenses and other current liabilities | 325,000 | 1,905,000 | 3,405,000 | 6,884,000 | 6,722,000 | 5,013,000 | 5,214,000 | ||||||||||||||
term loan, current portion | 2,913,000 | 4,159,000 | 5,000,000 | 5,000,000 | 5,000,000 | 5,000,000 | |||||||||||||||
other liabilities | 358,000 | 366,000 | 346,000 | 316,000 | |||||||||||||||||
term loan, net of current portion and discount | 404,000 | 1,647,000 | 2,889,000 | 4,129,000 | |||||||||||||||||
stockholders' equity: | |||||||||||||||||||||
total stockholders' equity | 104,567,000 | 106,897,000 | 111,611,000 | 140,861,000 | 157,682,000 | 171,161,000 | |||||||||||||||
total liabilities and stockholders' equity | 106,031,000 | 113,333,000 | 124,285,000 | 155,535,000 | 172,422,000 | 189,382,000 | |||||||||||||||
deferred offering costs | |||||||||||||||||||||
convertible notes | |||||||||||||||||||||
warrant liability | |||||||||||||||||||||
stockholders' equity | |||||||||||||||||||||
restricted cash | 323,000 | 323,000 | 323,000 |
Cashflow Statements:
Quarterly
Annual
| Unit: USD | 2026-03-31 | 2025-12-31 | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cash flows from operating activities | |||||||||||||||||||||
net loss | -63,504,000 | -60,531,000 | -62,321,000 | -55,247,000 | -34,085,000 | -29,457,000 | -26,599,000 | -26,352,000 | -26,949,000 | -23,579,000 | -14,122,000 | -15,947,000 | -22,781,000 | -21,229,000 | -17,823,000 | ||||||
adjustments to reconcile net loss to net cash from operations: | |||||||||||||||||||||
depreciation and amortization | 89,000 | 89,000 | 87,000 | 85,000 | 20,000 | 9,000 | 11,000 | 110,000 | 26,000 | 25,000 | 25,000 | 25,000 | 25,000 | ||||||||
stock-based compensation | 11,946,000 | 10,043,000 | 9,514,000 | 8,420,000 | 6,363,000 | 4,334,000 | 4,332,000 | 4,091,000 | 4,058,000 | 1,927,000 | 1,270,000 | 1,309,000 | 1,024,000 | ||||||||
amortization/accretion of investment securities | -1,069,000 | -1,632,000 | -1,739,000 | -2,621,000 | -2,527,000 | -2,212,000 | |||||||||||||||
non-cash lease expense | 129,000 | 124,000 | 120,000 | 117,000 | 112,000 | ||||||||||||||||
non-cash interest expense | 206,000 | 211,000 | 211,000 | 208,000 | 207,000 | 5,000 | 13,000 | 36,000 | 26,000 | 32,000 | 37,000 | 188,000 | |||||||||
other non-cash items | -12,000 | 15,000 | 15,000 | -48,000 | |||||||||||||||||
changes in operating assets and liabilities: | |||||||||||||||||||||
prepaid expenses and other current assets | -4,546,000 | -1,382,000 | 371,000 | -681,000 | -7,230,000 | 2,080,000 | 1,107,000 | 2,496,000 | -4,112,000 | -1,507,000 | 213,000 | 1,036,000 | -908,000 | 29,000 | 1,542,000 | 211,000 | -1,430,000 | 1,562,000 | -826,000 | -215,000 | -3,057,000 |
accounts payable | 2,741,000 | 1,750,000 | 918,000 | -321,000 | -1,277,000 | 4,395,000 | -1,047,000 | -669,000 | -7,360,000 | 3,969,000 | 3,766,000 | -726,000 | -10,750,000 | 2,337,000 | -478,000 | -3,492,000 | 2,159,000 | 2,021,000 | -501,000 | -2,131,000 | 2,173,000 |
accrued external research and development expenses | 686,000 | 3,746,000 | 242,000 | 42,000 | 280,000 | -9,191,000 | 5,981,000 | ||||||||||||||
other accrued expenses | -8,734,000 | 4,446,000 | 4,954,000 | 1,171,000 | -3,689,000 | 2,328,000 | 1,483,000 | ||||||||||||||
operating lease liabilities | -168,000 | -165,000 | -156,000 | 72,000 | 435,000 | -110,000 | -121,000 | -189,000 | -75,000 | 34,000 | 52,000 | -64,000 | -76,000 | ||||||||
net cash from operating activities | -62,236,000 | -43,300,000 | -47,799,000 | -47,918,000 | -41,376,000 | -27,573,000 | -17,361,000 | -15,393,000 | -33,599,000 | -17,796,000 | -7,476,000 | -12,724,000 | -35,466,000 | -12,405,000 | -4,011,000 | -9,498,000 | -16,338,000 | -12,668,000 | -16,097,000 | -15,928,000 | -15,007,000 |
capital expenditures | -20,000 | -26,000 | -36,000 | -851,000 | -449,000 | 8,000 | 3,000 | 6,000 | -45,000 | -12,000 | -21,000 | 0 | 0 | 0 | 0 | -10,000 | 0 | 0 | 0 | ||
free cash flows | -43,320,000 | -47,825,000 | -47,954,000 | -42,227,000 | -28,022,000 | -17,353,000 | -15,390,000 | -17,790,000 | -7,521,000 | -12,736,000 | -35,487,000 | -12,405,000 | -4,011,000 | -9,498,000 | -16,338,000 | -12,678,000 | -16,097,000 | -15,928,000 | -15,007,000 | ||
cash flows from investing activities | |||||||||||||||||||||
purchases of marketable securities | -93,762,000 | -358,273,000 | -85,436,000 | -58,626,000 | -347,250,000 | -72,777,000 | -94,098,000 | ||||||||||||||
maturities of marketable securities | 152,069,000 | 135,400,000 | 135,000,000 | 110,351,000 | 75,468,000 | 71,800,000 | |||||||||||||||
purchases of property and equipment | -20,000 | -26,000 | -36,000 | -851,000 | -449,000 | 8,000 | 3,000 | -67,000 | -3,000 | -45,000 | -12,000 | -29,000 | |||||||||
net cash from investing activities | 58,307,000 | -222,893,000 | 49,538,000 | 51,689,000 | -272,633,000 | -1,426,000 | -71,090,000 | -219,749,000 | -67,000 | -3,000 | -45,000 | -12,000 | -29,000 | 405,000 | |||||||
cash flows from financing activities | |||||||||||||||||||||
proceeds from sale of common stock in underwritten offering, net of issuance costs paid | 0 | 0 | 234,003,000 | ||||||||||||||||||
proceeds from sale of pre-funded warrants in underwritten offering, net of issuance costs paid | 0 | 0 | 9,386,000 | ||||||||||||||||||
proceeds from stock option exercises | 1,010,000 | 5,643,000 | 1,531,000 | 892,000 | 575,000 | 1,202,000 | 401,000 | 567,000 | 806,000 | 806,000 | 618,000 | 1,076,000 | 222,000 | ||||||||
contributions from employee stock purchase plan | 687,000 | 0 | 291,000 | 0 | 287,000 | 0 | 196,000 | 0 | 245,000 | ||||||||||||
net cash from financing activities | 1,697,000 | 216,676,000 | 11,588,000 | 892,000 | 244,251,000 | 28,797,000 | 426,000 | 173,191,000 | 15,900,000 | 7,758,000 | 460,000 | 153,855,000 | 77,306,000 | 154,344,000 | -2,911,000 | -1,230,000 | -1,225,000 | -1,179,000 | -1,250,000 | -1,581,000 | 195,490,000 |
net decrease in cash, cash equivalents and restricted cash | -2,232,000 | 13,327,000 | 4,663,000 | -69,758,000 | |||||||||||||||||
cash, cash equivalents and restricted cash, beginning of period | 91,387,000 | 0 | 0 | 0 | 192,672,000 | 0 | 0 | 0 | 360,616,000 | 0 | 0 | 0 | 194,788,000 | ||||||||
cash, cash equivalents and restricted cash, end of period | 89,155,000 | -49,517,000 | 13,327,000 | 4,663,000 | 122,914,000 | -202,000 | -88,025,000 | -61,951,000 | 342,850,000 | -10,041,000 | -7,061,000 | 141,119,000 | 236,599,000 | ||||||||
loss from initial consolidation of variable interest entity | 0 | 0 | |||||||||||||||||||
proceeds from sale of common stock in underwritten offerings, net of issuance costs paid | |||||||||||||||||||||
proceeds from sale of pre-funded warrants in underwritten offerings, net of issuance costs paid | |||||||||||||||||||||
proceeds from sale of common stock in at-the-market offerings, net of issuance costs paid | 0 | 0 | 0 | -59,000 | 14,849,000 | 14,605,000 | |||||||||||||||
proceeds from issuance of long-term debt, net of issuance costs paid | |||||||||||||||||||||
payment of debt issuance costs | |||||||||||||||||||||
net increase in cash, cash equivalents and restricted cash | -202,000 | -88,025,000 | -61,951,000 | -17,766,000 | -10,041,000 | -7,061,000 | 141,119,000 | 41,811,000 | |||||||||||||
proceeds from sale of common stock in offerings, net of issuance costs paid | 0 | -171,000 | 6,952,000 | -100,000 | |||||||||||||||||
proceeds from sale of pre-funded warrants in offerings, net of issuance costs paid | 0 | -58,000 | |||||||||||||||||||
change in fair value of contingent value right liability | 0 | ||||||||||||||||||||
noncash lease expense | 36,000 | 146,000 | 142,000 | 110,000 | 46,000 | 50,000 | 84,000 | ||||||||||||||
supplemental cash flow information | |||||||||||||||||||||
cash paid for income taxes | 4,000 | 34,000 | |||||||||||||||||||
supplemental disclosure of non-cash activities | |||||||||||||||||||||
right-of-use assets obtained in exchange for new operating lease liabilities | 0 | 0 | |||||||||||||||||||
net increase in right-of-use assets related to lease modifications and reassessment events | |||||||||||||||||||||
net increase in operating lease liabilities related to lease modifications and reassessment events | |||||||||||||||||||||
deferred issuance costs on sale of common stock and pre-funded warrants in offerings included in accounts payable and accrued expenses | 10,000 | -343,000 | |||||||||||||||||||
amortization/ accretion of investment securities | |||||||||||||||||||||
cash flow from investing activities | |||||||||||||||||||||
cash flow from financing activities | |||||||||||||||||||||
net decrease in right-of-use assets related to lease modifications and reassessment events | |||||||||||||||||||||
net decrease in operating lease liabilities due to lease modifications and reassessment events | |||||||||||||||||||||
receivable related to deferred issuance costs on sale of common stock and pre-funded warrants in offerings included in other current assets | |||||||||||||||||||||
accrued expenses | 671,000 | 2,725,000 | 1,274,000 | 93,000 | -2,084,000 | ||||||||||||||||
purchases of property and equipment included in accounts payable and accrued expenses | 9,000 | 8,000 | |||||||||||||||||||
receivable for proceeds from stock option exercises included in other current assets | 845,000 | ||||||||||||||||||||
change in fair value of derivative liability | |||||||||||||||||||||
other assets | 25,000 | 6,000 | 13,000 | 20,000 | -5,000 | 327,000 | -334,000 | -225,000 | |||||||||||||
proceeds from the issuance of common stock in pre-closing financing | |||||||||||||||||||||
cash acquired in connection with the reverse recapitalization | |||||||||||||||||||||
payment of reverse recapitalization transaction costs | |||||||||||||||||||||
settlement of derivative liability upon issuance of common stock to roche | |||||||||||||||||||||
decrease in right-of-use assets related to lease modifications | |||||||||||||||||||||
decrease in operating lease liabilities due to lease modifications | |||||||||||||||||||||
decrease in right-of-use assets related to lease modification | |||||||||||||||||||||
decrease in operating lease liabilities due to lease modification | |||||||||||||||||||||
proceeds from sale of common stock in registered direct offering, net of issuance costs paid | 34,217,000 | ||||||||||||||||||||
proceeds from sale of pre-funded warrants in registered direct offering, net of issuance costs paid | 28,262,000 | ||||||||||||||||||||
deferred issuance costs on sale of common stock in registered direct offering included in accounts payable and accrued expenses | 69,000 | ||||||||||||||||||||
deferred issuance costs on sale of pre-funded warrants in registered direct offering included in accounts payable and accrued expenses | 56,000 | ||||||||||||||||||||
deferred issuance costs on sale of common stock in at-the-market offerings included in accounts payable and accrued expenses | 97,000 | ||||||||||||||||||||
deferred issuance costs on equity financing included in accounts payable and accrued expenses | |||||||||||||||||||||
noncash license expense | |||||||||||||||||||||
proceeds from issuance of convertible preferred stock, net of issuance costs | |||||||||||||||||||||
deferred issuance costs on series b convertible preferred stock in accounts payable and accruals | |||||||||||||||||||||
deferred offering costs included in accounts payable and accruals at end of period | |||||||||||||||||||||
cash flows from operating activities: | |||||||||||||||||||||
adjustments to reconcile net loss to net cash from operating activities: | |||||||||||||||||||||
depreciation expense | 46,000 | 58,000 | 62,000 | 65,000 | |||||||||||||||||
stock-based compensation expense | 941,000 | 2,356,000 | 1,976,000 | 1,673,000 | 1,659,000 | 2,862,000 | 1,593,000 | ||||||||||||||
loss on conversion of convertible notes | 0 | 0 | 0 | 711,000 | |||||||||||||||||
accretion of discount on convertible notes | 0 | 0 | 0 | 1,600,000 | |||||||||||||||||
deferred offering or transaction costs | |||||||||||||||||||||
accrued expenses and other current liabilities | -1,581,000 | -1,509,000 | -3,868,000 | 135,000 | 1,705,000 | 238,000 | -348,000 | ||||||||||||||
cash flows from investing activities: | |||||||||||||||||||||
purchase of property and equipment | -10,000 | ||||||||||||||||||||
cash flows from financing activities: | |||||||||||||||||||||
proceeds from business combination | 0 | 0 | -437,000 | 196,319,000 | |||||||||||||||||
proceeds from exercise of stock options | 6,000 | 9,000 | 25,000 | 71,000 | 0 | 106,000 | 4,000 | ||||||||||||||
proceeds from sale of stock under employee stock purchase plan | 0 | ||||||||||||||||||||
principal payments on term loan | -2,917,000 | -1,250,000 | -1,250,000 | -1,250,000 | -1,250,000 | -1,250,000 | -833,000 | ||||||||||||||
increase in cash, cash equivalents and restricted cash | -6,922,000 | -10,728,000 | -17,563,000 | -13,442,000 | -17,408,000 | -17,509,000 | 180,483,000 | ||||||||||||||
cash, cash equivalents and restricted cash at beginning of period | 0 | 0 | 136,950,000 | 0 | 0 | 4,826,000 | |||||||||||||||
cash, cash equivalents and restricted cash at end of period | -6,922,000 | -10,728,000 | 119,387,000 | -17,408,000 | -17,509,000 | 185,309,000 | |||||||||||||||
supplemental disclosure | |||||||||||||||||||||
cash paid for interest | 35,000 | 36,000 | 47,000 | 59,000 | 104,000 | 84,000 | 60,000 | ||||||||||||||
noncash financing activities | |||||||||||||||||||||
proceeds from exercise of stock options included in other current assets | 60,000 | ||||||||||||||||||||
conversion of convertible notes to series b preferred stock | 0 | 0 | 0 | 14,515,000 | |||||||||||||||||
exercise of warrants | 0 | 0 | 0 | 76,000 | |||||||||||||||||
property and equipment purchases included in accounts payable and accrued expenses | -52,000 | ||||||||||||||||||||
net income | -7,090,000 | -15,231,000 | -16,447,000 | -19,048,000 | |||||||||||||||||
adjustments to reconcile net income to net cash from operating activities: | |||||||||||||||||||||
deferred offering costs | 0 | 0 | 0 | 1,341,000 | |||||||||||||||||
cash - fsdc trust account and cash | 0 | 121,782,000 | 0 | 121,782,000 | |||||||||||||||||
cash - pipe financing | 0 | 95,060,000 | 0 | 95,060,000 | |||||||||||||||||
less: equity issuance costs and other costs paid | 0 | -20,960,000 | |||||||||||||||||||
net proceeds from the business combination | 0 | 195,882,000 | 0 | 195,882,000 | |||||||||||||||||
unpaid issuance costs in accounts payable and accrued expenses and other current liabilities | 437,000 | ||||||||||||||||||||
gain on the sale of property and equipment | |||||||||||||||||||||
change in fair value of warrant liability | |||||||||||||||||||||
proceeds from the sale of property and equipment | |||||||||||||||||||||
proceeds from sale of series b convertible preferred stock | |||||||||||||||||||||
proceeds from convertible notes | |||||||||||||||||||||
cash, cash equivalents and restricted cash at beginning of year | |||||||||||||||||||||
cash, cash equivalents and restricted cash at end of year | |||||||||||||||||||||
noncash investing and financing activities | |||||||||||||||||||||
proceeds from the sale of property and equipment included in other current assets | |||||||||||||||||||||
discount on convertible notes | |||||||||||||||||||||
deferred offering costs included in accounts payable and accrued expenses and other current liabilities | |||||||||||||||||||||
less: equity issuance costs and other costs paid prior to june 30, 2021 | |||||||||||||||||||||
less: underwriting fees and other issuance costs paid prior to march 31, 2021 | -20,523,000 | ||||||||||||||||||||
proceeds from business combination, net of issuance costs paid per the cash flows from financing activities | 196,319,000 | ||||||||||||||||||||
less: other issuance costs included in accounts payable and accrued expenses and other current liabilities | -437,000 |
