7Baggers
Quarterly
Annual
    Unit: USD2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-09-30 2018-06-30 2018-03-31 2017-09-30 2017-06-30 2017-03-31 2016-09-30 2016-06-30 2016-03-31 2015-09-30 2015-06-30 2015-03-31 2014-09-30 2014-06-30 2014-03-31 2013-09-30 2013-06-30 2013-03-31 2012-09-30 2012-06-30 2012-03-31 2011-09-30 2011-06-30 2011-03-31 2010-09-30 2010-06-30 2010-03-31 2009-09-30 2009-06-30 2009-03-31 2008-09-30 2008-06-30 2008-03-31 2007-09-30 2007-06-30 2007-03-31 2006-12-31 2006-09-30 2006-06-30 2006-03-31 2005-12-31 2005-09-30 2005-06-30 2005-03-31 2004-12-31 
      
                                                                            
      cash flows from operating activities
                                                                            
      net income
    89,908,000 63,688,000 -46,584,000 20,332,000 1,213,000 -34,685,000 36,532,000 61,531,000 82,046,000 1,280,000 34,865,000 -68,314,000 229,347,000 21,371,000 37,858,000 45,650,000 102,646,000 110,846,000 109,695,000 75,016,000 41,621,000 98,225,000 78,952,000 57,862,000 47,051,000 46,061,000 40,019,000 50,167,000 56,616,000 30,330,000 23,767,000 35,146,000 16,845,000 15,033,000 14,597,000 4,435,000 -4,584,000 -7,810,000 -10,667,000 -21,271,000 -63,564,000 -67,703,000 -46,983,000 -36,429,000 -37,360,000 -34,692,000 -37,120,000 84,594,000 -30,625,000 -25,045,000 -22,667,000 -21,222,000 -20,805,000 -22,536,000 -22,183,000 -21,692,000 -19,217,000 -20,928,000 -27,026,000 -29,764,000 -32,364,000 -45,125,000 -49,450,000 -37,837,000 -37,780,000 -41,475,000 -48,952,000 -42,211,000 -37,786,000 -31,716,000 -31,451,000 -29,171,000 
      adjustments to reconcile net income to net cash from operating activities:
                                                                            
      deferred income taxes
    4,949,000 -637,000 -240,000 2,821,000 -3,429,000 -15,253,000 3,244,000 5,515,000 -1,648,000 1,345,000 -812,000     10,832,000           8,508,000                                              
      amortization of capitalized fees and depreciation of property and equipment
    3,488,000 3,488,000 3,488,000 3,485,000 3,480,000 3,476,000 3,510,000 3,484,000 3,483,000 3,475,000 3,479,000                                                              
      amortization of acquired intangible assets
    6,618,000 6,547,000 6,475,000 6,511,000 6,511,000 6,440,000 6,440,000 6,510,000 6,511,000 4,958,000 3,805,000                                                              
      inventory fair value step-up adjustment included in cost of products sold
    3,484,000 381,000 244,000 1,719,000 1,795,000 3,463,000 6,843,000 7,985,000 5,429,000 6,908,000 6,842,000                                                              
      stock-based compensation
    2,380,000 2,422,000 2,147,000 1,673,000 1,603,000 1,643,000 1,455,000 1,277,000 1,442,000 1,520,000 1,598,000 1,326,000 3,717,000 1,350,000 954,000 554,000 542,000 470,000 451,000 447,000 441,000 375,000 435,000 488,000 489,000 474,000 605,000 -874,000 1,452,000 2,169,000 2,472,000 2,427,000 2,507,000 1,718,000 2,841,000 1,864,000 1,468,000 1,822,000 1,933,000 4,732,000 7,746,000 13,535,000 6,447,000 7,162,000 6,095,000 5,830,000 5,979,000 6,235,000 7,572,000 5,593,000 5,541,000 4,496,000 5,323,000 4,497,000 4,996,000 5,274,000 5,113,000 4,756,000 3,732,000 4,914,000 5,874,000 5,505,000 5,788,000 5,347,000 4,716,000   1,689,000 1,092,000 1,434,000 1,408,000 2,361,000 
      amortization of debt discount and issuance costs
    455,000 537,000 541,000 529,000 533,000 523,000 525,000 516,000 517,000 509,000 523,000 564,000 560,000 554,000 377,000 2,358,000           1,889,000 1,867,000 1,936,000 2,092,000                                           
      changes in fair values of equity method investments
    -30,751,000 -13,082,000 13,549,000 21,256,000 18,231,000 60,108,000 -35,342,000 -9,506,000 -71,980,000 19,911,000 -15,817,000                                                              
      changes in fair values of equity and long-term investments
    -31,510,000 -11,280,000 65,299,000 -1,666,000 16,936,000 30,556,000 13,335,000      -1,563,000 58,600,000 9,411,000 43,176,000                                                         
      acquired in-process research and development assets
                                                                            
      other non-cash items
    -21,000 -376,000 799,000 -398,000 -171,000 1,360,000 -1,513,000 253,000 -1,831,000 3,123,000 -2,062,000     -8,000                                                         
      changes in operating assets and liabilities:
                                                                            
      accounts receivable
    -9,242,000 -4,252,000 3,719,000 10,154,000 -3,764,000 -12,643,000 315,000 -3,702,000 4,523,000 215,000 -6,089,000 -2,658,000                                                             
      receivables from collaboration arrangement
    3,984,000 -6,073,000 4,711,000  6,686,000 -5,327,000 7,750,000  8,708,000 -5,407,000 -5,642,000                                                              
      inventory
    6,847,000 -7,993,000 -9,153,000 -1,208,000 633,000 -2,690,000 -3,543,000 -8,207,000 902,000 -4,101,000 -598,000 -70,000                                                             
      prepaid expenses
    -2,805,000 -1,196,000 5,649,000 -8,413,000 -4,166,000 8,067,000 5,079,000 -6,901,000 5,806,000 3,584,000 5,440,000 -21,627,000 -2,691,000 1,623,000 1,345,000                                                          
      other assets
    227,000 223,000 551,000 -38,780,000 -1,010,000 971,000 633,000 -4,760,000 261,000 1,016,000 518,000                                                              
      accounts payable
    861,000 682,000 2,568,000 -2,038,000 2,131,000 1,149,000 -5,827,000 2,934,000 -809,000 -1,341,000 2,994,000 -866,000 -1,755,000 2,515,000 198,000 -62,000 59,000 16,000 -52,000 -557,000 428,000 73,000 112,000 -25,000 -1,104,000 995,000 133,000    352,000 -2,027,000 2,176,000    -308,000 -563,000 1,025,000    1,014,000     48,000 633,000 615,000 198,000                      
      accrued personnel-related expenses and other accrued liabilities
    -16,500,000 6,741,000 -4,809,000 7,021,000 1,973,000 -6,391,000 441,000 -426,000 2,188,000 -2,695,000 -565,000 13,622,000 -8,648,000 4,823,000 2,116,000 276,000 176,000 -936,000 227,000 552,000 267,000 111,000 -126,000 -546,000 -236,000 177,000 166,000     -510,000 752,000                                        
      accrued interest payable
    -3,187,000 2,585,000 -2,589,000    -2,589,000 2,589,000 -2,589,000 2,589,000 -3,526,000 2,133,000 -2,272,000 3,101,000 -2,755,000    -2,484,000    -2,484,000 2,379,000 -2,489,000               8,454,000                                 
      income tax payable
    728,000 -455,000 2,376,000 38,705,000 2,228,000 494,000 49,000 1,577,000 49,000 50,000 49,000 -23,778,000                                                             
      deferred revenue
    10,446,000 2,123,000 -124,000 409,000 -138,000 -132,000 -290,000 -271,000 -1,706,000                                  -428,000 -826,000 4,946,000                19,330,000 -5,305,000 26,603,000 -4,931,000 4,475,000      2,243,000 -2,740,000 
      net cash from operating activities
    49,727,000 44,073,000 48,617,000 59,239,000 48,686,000 43,718,000 37,047,000 33,256,000 43,942,000 38,182,000 25,684,000 8,899,000 15,690,000 79,035,000 98,102,000 98,381,000 96,711,000 84,614,000 84,107,000 85,280,000 74,558,000 79,794,000 73,481,000 66,905,000 57,402,000 56,496,000 76,655,000 60,115,000 51,725,000 49,914,000 43,490,000 22,639,000 27,761,000 20,188,000 12,460,000 7,250,000 2,656,000                                    
      capex
    -151,000 -227,000 -33,000 -34,000 -11,000 -13,000 -9,000                                    
      free cash flows
    49,727,000 44,073,000 48,617,000 59,239,000 48,686,000 43,718,000 37,047,000 33,105,000 43,715,000 38,182,000 25,651,000 8,865,000 15,679,000 79,022,000 98,093,000 98,381,000 96,711,000 84,614,000 84,107,000 85,280,000 74,558,000 79,794,000 73,481,000 66,905,000 57,402,000 56,496,000 76,655,000 60,115,000 51,725,000 49,914,000 43,490,000 22,639,000 27,761,000 20,188,000 12,460,000 7,250,000 2,656,000                                    
      cash flows from investing activities
                                                                            
      purchases of trading securities
    -15,000,000 -34,674,000 -11,481,000 -5,000,000 -43,136,000 -5,000,000                                                                 
      proceeds from trading securities
                                                                           
      purchases of equity investments managed by isp fund lp
       -1,378,000 -22,136,000 -8,756,000 -6,250,000 -7,130,000 -13,893,000 -3,891,000 32,041,000 -54,925,000 -36,011,000 -2,015,000                                                          
      sales of equity investments managed by isp fund lp
    19,939,000 22,925,000 46,855,000 634,000 5,342,000 32,858,000 37,160,000 1,193,000 1,289,000 24,281,000                                                          
      purchases and sales of other investments managed by isp fund lp
    43,901,000 28,025,000 -19,939,000 -22,925,000 -45,477,000 21,502,000 3,414,000  -30,030,000 12,700,000 2,602,000                                                              
      purchases of property and equipment
          -151,000 -227,000 -33,000 -34,000 -11,000 -13,000 -9,000                                                         
      cash paid for in-process research and development assets acquired
                                                                            
      sale of property and equipment
       3,000 98,000                                                                  
      net cash from investing activities
    18,412,000 33,122,000 -34,674,000 -15,478,000 -5,270,000 -43,038,000 -5,151,000 -25,888,000 -35,722,000 -8,678,000 97,722,000 -2,522,000 -143,156,000 -19,905,000 90,021,000 -26,394,000 -315,481,000        13,522,000 9,078,000 26,513,000 -21,774,000 2,023,000 22,395,000   11,693,000 -47,875,000 34,045,000 73,710,000  -11,234,000 14,130,000      8,384,000         2,532,000    41,745,000 7,398,000 20,358,000      -12,606,000 7,540,000 9,270,000  
      cash flows from financing activities
                                                                            
      repurchase of common stock
       -5,208,000 -9,569,000 -14,636,000 -11,071,000 -9,286,000 -40,735,000                                                             
      repurchase of shares to satisfy tax withholding
    -25,000 -24,000 -67,000 -19,000 -18,000 -21,000 -84,000 -12,000 -11,000 -31,000 -23,000 -11,000 -12,000 -13,000 -46,000 -13,000                                                         
      proceeds from issuances of common stock
    194,000 1,271,000 250,000 592,000 229,000 157,000 488,000 59,000   28,000 1,000 81,000 260,000 1,046,000           319,000 340,000 114,000 3,000 177,000 8,000 6,000 162,000 173,000 3,485,000 1,425,000 1,086,000 11,843,000 5,514,000 18,272,000 113,570,000 23,442,000 2,991,000 12,416,000 214,268,000 2,532,000 1,360,000 9,824,000 11,733,000 1,436,000 2,563,000 94,057,000 1,571,000 1,349,000 4,964,000                
      proceeds from exercise of warrants
                                                                            
      payment for repurchase of convertible subordinated notes due 2025
                                                                            
      net cash from financing activities
    10,842,000 1,247,000 183,000 573,000 211,000 -5,072,000 -9,165,000 -14,589,000 -11,082,000 -9,206,000 -136,962,000 -10,001,000 -96,163,000 -9,735,000 60,331,000 -12,066,000 -4,861,000 -414,260,000 -21,310,000 -2,505,000 -12,000 -11,628,000 -15,640,000 -13,749,000 -10,471,000 198,000 246,000             -7,861,000 148,416,000 18,272,000 113,569,000 23,392,000 247,864,000 12,416,000 214,255,000 2,476,000 1,307,000 9,773,000 11,671,000 1,377,000 2,529,000 94,002,000 1,530,000 1,321,000 4,935,000 2,698,000 2,607,000 166,923,000 1,332,000 3,540,000 603,000 1,175,000 839,000 2,403,000 141,557,000 1,361,000 737,000   108,440,000 
      net increase in cash and cash equivalents
    78,981,000 78,442,000 14,126,000 44,334,000 43,627,000   13,516,000 6,972,000 28,976,000 -147,000,000   66,778,000 15,277,000 66,410,000 91,850,000 -239,625,000 36,403,000 -232,706,000 66,046,000 61,166,000 73,885,000 105,150,000 30,994,000 76,801,000 2,734,000    10,783,000 -32,174,000 41,792,000     8,393,000 44,386,000    -27,351,000 -66,827,000 171,221,000 -48,861,000      -6,620,000 -40,202,000 62,379,000    41,356,000     4,764,000 -13,342,000 832,000 -18,624,000 53,735,000     63,407,000 
      cash and cash equivalents at beginning of period
    304,964,000 193,513,000 291,049,000 201,525,000 246,487,000 278,096,000 62,417,000 73,336,000 118,016,000 159,180,000 96,800,000 143,510,000 94,849,000 44,778,000 163,333,000 47,544,000 92,280,000 86,433,000 72,388,000 49,787,000 101,411,000 
      cash and cash equivalents at end of period
    78,981,000 78,442,000 319,090,000 44,334,000 43,627,000 38,646,000 178,357,000 13,516,000 6,972,000 28,976,000 144,049,000   66,778,000 216,802,000 66,410,000 91,850,000 -239,625,000 282,890,000 -232,706,000 66,046,000 61,166,000 351,981,000 105,150,000 30,994,000 76,801,000 65,151,000 -38,611,000 60,088,000 27,138,000 10,783,000 -32,174,000 159,808,000 -19,751,000 -38,833,000 151,778,000 -70,833,000 8,393,000 141,186,000 -88,477,000 82,777,000 125,275,000 -27,351,000 -66,827,000 266,070,000 -48,861,000 146,786,000 14,310,000 -27,922,000 -57,216,000 147,874,000 -6,620,000 -40,202,000 109,923,000 4,491,000 -11,820,000 72,918,000 41,356,000 6,327,000 81,283,000 33,315,000 -31,607,000 77,152,000 -13,342,000 832,000 -18,624,000 103,522,000 27,428,000 -41,520,000 -21,620,000 85,499,000 63,407,000 
      loss on extinguishment of debt
               20,662,000             2,608,000 3,137,000                                           
      net gain on sale of trc
                                                                           
      receivables from collaboration arrangements
                                                                            
      acquisition of intangible asset
                                                                            
      purchases of equity method investments
                                                                            
      purchases of equity and long-term investments
           34,471,000 -35,689,000 1,000 -2,509,000 -56,217,000 -19,905,000 -19,979,000 -26,394,000                                                      
      purchases of trading security managed by isp fund lp
                                                                            
      proceeds from sale of ownership interest in trc
                                                                           
      cash acquired through the consolidation of entasis
                                                                           
      cash paid for the acquisition of la jolla, net of cash acquired
                                                                            
      distributions to noncontrolling interests
                                                                           
      purchase of entasis noncontrolling interest
                                                                            
      payment for repurchase of convertible subordinated notes due 2023
           -96,204,000 -165,131,000                                                          
      purchases of capped call options associated with convertible senior notes due 2028
               -21,037,000                                                          
      proceeds from issuance of convertible senior notes due 2028, net of issuance costs
               -256,000 252,792,000                                                          
      accrued interest income added to long-term investments
            -1,482,000                                                              
      net decrease in cash and cash equivalents
          -15,156,000                                                                  
      purchase and sales of other investments managed by isp fund lp
                 36,011,000 -132,266,000                                                          
      changes in fair values of other equity and long-term investments
            2,640,000 83,000 2,164,000                                                              
      cash paid for the acquisition of la jolla pharmaceutical company, net of cash acquired
                                                                            
      purchase of entasis minority interest
                                                                            
      fair value adjustments included in cost of products sold
                                                                            
      amortization of discount on short-term investments
                                                                            
      amortization of lease guarantee
                                                                            
      maturities of marketable securities
                       4,000,000 28,000,000 54,000,000 52,999,000 103,050,000 30,000,000 27,875,000 16,500,000 23,000,000 31,875,000 8,000,000 10,000,000 26,387,000 8,000,000 16,430,000 27,671,000 30,191,000 34,045,000 25,075,000        108,763,000 45,158,000 44,925,000 48,226,000 71,250,000 31,500,000 26,000,000 44,000,000 50,000,000 20,565,000 27,500,000 110,175,000 111,982,000 12,020,000 62,451,000 -2,226,000 40,720,000          
      purchases of marketable securities
                       -12,943,000 -993,000 -118,987,000                                                
      net proceeds from the issuance of variable interest entity’s equity
                                                                            
      deferred income tax
                23,274,000 -876,000 6,860,000                                                          
      depreciation and amortization
                5,415,000 3,591,000 3,501,000 3,456,000 3,458,000 3,458,000 3,460,000 3,458,000 3,461,000 3,458,000 3,463,000 3,474,000 3,320,000 3,541,000 3,539,000 3,468,000 3,468,000 3,468,000 3,496,000 3,495,000 3,496,000 3,491,000 3,484,000 3,483,000 3,483,000 3,483,000 3,483,000 2,530,000 2,790,000 3,400,000 1,794,000 1,992,000 1,898,000 1,890,000 1,662,000 1,910,000 2,052,000 1,757,000 1,650,000 1,560,000 1,622,000 1,515,000 1,497,000 1,324,000 1,205,000 1,588,000   834,000 820,000 871,000  1,047,000 1,061,000 980,000  1,035,000    
      amortization of inventory fair value adjustments included in cost of products sold
                                                                            
      amortization of deferred royalty obligation value adjustment
                                                                            
      other
                138,000 577,000 280,000                                                          
      other assets, current
                -218,000 811,000 99,000                                                          
      other assets, non-current
                -2,780,000                                                            
      net increase in cash, cash equivalents and restricted cash
                                                                            
      cash, cash equivalents and restricted cash at end of period
                                                                            
      receivables from collaborative arrangements
                 -18,161,000 17,196,000 -9,440,000 2,991,000 -15,288,000 4,957,000 -1,781,000 -9,748,000 -268,000 -2,707,000 -10,216,000 -1,648,000 -8,924,000 24,647,000   14,705,000   3,120,000      311,000   2,316,000                               
      cash acquired through the consolidation of entasis therapeutics holdings, inc.
                 23,070,000                                                          
      distributions to noncontrolling interest
                 -9,547,000 -6,507,000 -13,099,000                                                         
      supplemental disclosure of cash flow information:
                                                                            
      cash paid for interest
                 5,411,000 4,966,000 4,967,000 4,966,000 4,967,000 300,000 5,213,000 243,000 5,218,000 6,709,000 1,972,000 8,941,000 12,246,000 10,788,000 13,522,000 13,597,000 11,008,000 13,124,000 8,215,000 4,084,000 6,870,000                         60,000 37,000 38,000 58,000 51,000 60,000 75,000 123,000 100,000 
      supplemental disclosure of non-cash investing and financing activities
                                                                            
      adoption of asu 2020-06
                 28,123,000                                                          
      right-of-use asset obtained through the consolidation of entasis therapeutics holdings, inc.
                 3,289,000                                                          
      loss on write-off of property and equipment
                                                                            
      prepaid expenses and other current assets
                   -895,000 192,000 335,000 571,000 -942,000 -53,000 177,000 140,000 -579,000 76,000 243,000 147,000 63,000   203,000   204,000   82,000 316,000 121,000          266,000 1,644,000 73,000                      
      other long-term liabilities
                              2,000 2,000 3,000 5,000 5,000                      -77,000 -77,000 620,000    650,000 4,979,000 382,000  440,000 408,000 442,000      
      payments of principal on senior secured term loans
                                                                            
      payments of cash dividends to stockholders
                                                                            
      supplemental disclosure of cash flow information
                                                                            
      leasehold improvements
                                                                            
      equipment, furniture and fixtures
                                                                            
      software and computer equipment
                                                                            
      distributions of equity and long-term investments
                                                                            
      numerator:
                                                                            
      net income attributable to innoviva stockholders, basic
                    -16,510,000 -5,175,000 94,123,000  -48,626,000 11,407,000 65,437,000                                                  
      add: interest expense on 2023 notes
                    23,000                                                        
      net income attributable to innoviva stockholders, diluted
                    -16,487,000 -5,216,000 95,327,000  -48,639,000 11,411,000 66,617,000                                                  
      denominator:
                                                                            
      weighted-average shares used for eps calculation
                    -18,965,000    34,000 89,000 101,235,000                                                  
      dilutive effect of 2023 notes
                                                                           
      dilutive effect of options and awards granted under equity incentive plan and employee stock purchase plan
                    25,000                                                        
      net income per share
                                                                            
      basic
                    30 80 930  -480 110 650                                                  
      diluted
                    60 840  -430 100 590                                                  
      ​
                                                                            
      changes in fair values of equity investments
                                                                            
      purchases of equity and other long term investments
                                                                            
      net proceeds from the issuance of variable interest entity's equity
                                                                            
      purchases of equity investments
                                                                            
      operating lease liability
                                                                            
      sales of marketable securities
                                       57,098,000          3,750,000 5,000,000       1,500,000 12,304,000 -1,421,000 31,446,000 23,863,000          
      proceeds from issuance of convertible senior notes due 2025
                                                                            
      proceeds from senior secured term loans
                                                                            
      payments of debt issuance costs and debt discount
                                                                            
      payments of principal on non-recourse notes due 2029
                                                                            
      contributions from (distributions to) noncontrolling interest
                                                                            
      amortization of premium (discount) on short-term investments
                                                                            
      payment of principal on non-recourse notes due 2029
                                                                            
      gain on extinguishment of debt
                                  6,426,000                                          
      interest added to the principal balance of non-recourse notes due 2029
                                                                            
      realized gain on sale of marketable securities
                                                                            
      repurchase of convertible subordinated notes due 2023
                                                                            
      proceeds from capped-call options
                                                                           
      amortization of debt issuance costs
                                   714,000 687,000 724,000 715,000 699,000 769,000 763,000 764,000                                  
      amortization of premium (discount) on short term investment
                                    17,000                                        
      interest added to the principal balance of the non-recourse term notes due 2029
                                     172,000 683,000 5,613,000 6,409,000 6,427,000                                  
      gain on repurchase of convertible subordinated notes due 2023
                                                                            
      payable to theravance biopharma, inc.
                                                                            
      amortization of premium on short-term investments
                                        134,000                                    
      inventories
                                                                            
      accrued personnel-related expenses, accrued clinical and development expenses, and other accrued liabilities
                                           -1,803,000 -2,574,000 4,448,000 1,531,000                              
      deferred rent
                                           41,000         404,000 1,156,000 776,000 706,000             -1,000 35,000 -31,000 100,000 35,000 34,000 68,000 
      capitalized fees paid to a related party
                                                                            
      payments received on notes receivable
                                             100,000    100,000 230,000 300,000 30,000 100,000 10,000 1,000 238,000 171,000 155,000 5,000 2,000 1,163,000  139,000 200,000 53,000      
      cash and cash equivalents contributed to theravance biopharma, inc.
                                                                            
      change in restricted cash
                                                                            
      proceeds from issuances of notes payable, net of debt issuance costs
                                                                           
      supplemental disclosure of noncash information
                                                                            
      contribution of net assets, excluding cash and cash equivalents to theravance biopharma, inc.
                                                                           
      conversion of convertible subordinated notes into common stock
                                                                            
      guarantee issued in connection with the spin-off
                                                                            
      increase in intangible assets
                                                                            
      amortization of premium on short term investment
                                          233,000                                  
      payments for capitalized fees paid to a related party
                                                                            
      amortization of premium on marketable securities
                                                                            
      change in fair value of capped-call derivative assets
                                                                            
      account receivables
                                                                           
      payments for intangible assets
                                                                            
      purchase of capped-call options
                                                                            
      supplemental disclosures of noncash information
                                                                            
      amortization on premium of short-term investments
                                                                            
      purchases of available-for-sale securities
                                                                            
      maturities of available-for-sale securities
                                            118,774,000 122,399,000 48,413,000 52,230,000 54,753,000                            
      sales of available-for-sale securities
                                            5,000,000 5,000,000                              
      accrued interest on convertible subordinated notes
                                                                            
      deferred rent expense
                                             116,000                               
      proceeds from issuances of convertible subordinated notes, net of debt issuance costs
                                                                            
      gain on marketable securities
                                                                            
      loss on disposal of assets
                                                                            
      change in capped-call option valuation
                                                                           
      release of restricted cash
                                                             20,000 30,000          
      issuances of notes receivable
                                                                            
      payments on note payable and capital lease
                                                                            
      payment for capped calls
                                                                            
      proceeds from issuances of convertible subordinated notes
                                              -1,000 -50,000 281,673,000                            
      supplemental non-cash financing activities:
                                                                            
      intangible asset
                                                                            
      gain on sale of available-for-sale securities
                                                                            
      change in capped call option valuation
                                                1,422,000                            
      sale of available-for-sale securities
                                                5,000,000                            
      payments for capped calls
                                                                            
      gain on sales of available-for-sale securities
                                                                            
      forgiveness of notes receivable
                                                    15,000 1,000       6,000 -8,000 11,000   12,000  12,000 13,000 17,000  43,000    
      receivables
                                                 23,000 -31,000 160,000   268,000                      
      accrued personnel-related expenses, accrued interest on convertible subordinated notes and other current liabilities
                                                                            
      purchases of short-term investments and marketable securities
                                                                            
      sales of short-term investments and marketable securities
                                                                            
      maturities of short-term investments and marketable securities
                                                                            
      recognized gain on marketable securities
                                                                            
      additions to notes receivable
                                                                            
      accrued personnel-related expenses, accrued clinical and development expenses, accrued interest on convertible subordinated notes and other current liabilities
                                                                            
      other liabilities, non-current
                                                                            
      payments on notes payable and capital lease
                                                                            
      notes receivable
                                                       14,000 1,000 3,000                   
      receivables, prepaid and other current assets
                                                       597,000 1,169,000 36,000 256,000      881,000       -219,000   472,000  
      accounts payable and accrued liabilities
                                                                  2,307,000 5,463,000 -1,575,000 -2,714,000 6,029,000 4,070,000 1,963,000 107,000 3,524,000 4,831,000 
      accrued personnel-related expenses
                                                                1,334,000   1,754,000        1,822,000 
      loss on sale of equipment
                                                                            
      proceeds from sale of equipment
                                                                            
      payments on notes payable
                                                                            
      proceeds from issuance of convertible subordinated notes, net of issuance costs
                                                             -1,000 166,733,000             
      net proceeds from issuances of common stock
                                                             2,725,000 2,631,000 214,000 1,354,000 3,562,000 624,000 1,659,000 992,000 2,750,000 141,823,000 1,662,000 1,055,000 2,775,000 715,000 109,460,000 
      cash flows used in operating activities
                                                                            
      depreciation
                                                               1,082,000           1,086,000 1,186,000 
      amortization
                                                               756,000             
      change in accrued interest receivable on marketable securities
                                                                            
      payments on notes payable and capital leases
                                                                            
      forgiveness (net cancellation) of notes receivable
                                                                            
      supplemental disclosures of cash flow information
                                                                            
      non-cash financing activity:
                                                                            
      removal of deferred stock-based compensation
                                                                            
      forgiveness (cancellation) of notes receivable
                                                                            
      non-cash investing and financing activities:
                                                                            
      other non-cash operating expenses
                                                                    -31,000 496,000 11,000  157,000 -241,000 396,000  
      forgiveness of notes receivables
                                                                          55,000 80,000 
      other non-cash operating activities
                                                                            
      receivables, prepaid and other assets
                                                                            
      other liabilities
                                                                            
      restricted cash and cash equivalents
                                                                       334,000 343,000 386,000 
      decrease in notes receivable
                                                                       71,000 43,000 51,000 413,000 -30,000 
      payments on notes payables and capital leases
                                                                            
      net proceeds from issuances of convertible preferred stock
                                                                           
      conversion of convertible preferred stock to common stock
                                                                           
      repurchases/issuances of common stock for notes receivable
                                                                            
      addition to (reversal of) deferred stock-based compensation
                                                                      -4,965,000      
      sales and maturities of marketable securities
                                                                    71,764,000 33,017,000 46,127,000 48,345,000 26,144,000 56,406,000 27,052,000 28,753,000 
      addition to (removal of) deferred stock-based compensation
                                                                           
      non-cash stock-based compensation
                                                                      5,013,000      
      cash flows used in financing activities
                                                                            
      deferred sublease costs
                                                                            
      net cash (used in) provide by investing activities
                                                                            
      proceeds from line of credit
                                                                            
      payments on line of credit
                                                                            
      deferred financing costs
                                                                            
      deferred stock-based compensation
                                                                           -2,047,000 
      addition to deferred stock-based compensation
                                                                        896,000  
      proceeds from notes payables and capital leases
                                                                            
      repurchases of common stock originally issued with notes receivable
                                                                            
    The information provided in this report is taken from www.sec.gov and many other data providers. While we have conducted our best efforts to ensure that the parsed data is accurate, we cannot guarantee its accuracy. Please use caution and understand that any consequences of its use are your own responsibility.