ImmunoGen, Inc(NASDAQ:IMGN)

ImmunoGen, Inc., a clinical-stage biotechnology company, develops antibody-drug conjugate (ADC) therapies to treat cancer. Its product candidates include mirvetuximab soravtansine, an ADC targeting folate-receptor alpha, which is in Phase III clinical trial for the treatment of platinum-resistant ov...
Website: http://www.immunogen.com
Founded: 1981
Full Time Employees: 75
Sector: Healthcare
Industry: Biotechnology
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| Unit: USD | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2017-12-31 | 2017-03-31 | 2016-09-30 | 2016-06-30 | 2016-03-31 | 2015-12-31 | 2015-09-30 | 2014-09-30 | 2013-12-31 | 2013-09-30 | 2013-03-31 | 2012-12-31 | 2012-09-30 | 2011-09-30 | 2010-12-31 | 2010-09-30 | 2010-03-31 | 2009-12-31 | 2009-09-30 | 2008-09-30 | 2007-12-31 | 2007-09-30 | 2007-06-30 | 2007-03-31 | 2006-12-31 | 2006-09-30 | 2006-06-30 | 2006-03-31 | 2005-12-31 | 2005-09-30 | 2005-03-31 | 2004-12-31 | 2004-09-30 | 2004-03-31 | 2003-12-31 | 2003-09-30 | 2003-03-31 | 2002-12-31 | 2002-09-30 | 2002-03-31 | 2001-12-31 | 2001-09-30 |
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revenues: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
product revenue | 105,164,000 | 77,371,000 | 29,544,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
license and milestone fees | 30,780,000 | 7,382,000 | 6,973,000 | 30,892,000 | 19,564,000 | 2,677,000 | 252,000 | 157,000 | 62,417,000 | 97,000 | 945,000 | 283,000 | 29,551,000 | 79,000 | 5,079,000 | 79,000 | 1,747,000 | 672,000 | 1,321,000 | 11,540,000 | 60,739,000 | 18,730,000 | 76,000 | 76,000 | 10,077,000 | 10,692,000 | 6,070,000 | 6,234,000 | 25,678,000 | 13,167,000 | 22,010,000 | 429,000 | 933,000 | 1,187,000 | 866,000 | 1,810,000 | 1,266,000 | 827,000 | 1,831,000 | 2,223,000 | 2,680,000 | 4,188,000 | -6,323,415 | 1,497,000 | 3,428,000 | 1,406,000 | 1,340,000 | 3,275,000 | 1,275,000 | 1,261,000 | 3,039,394 | ||||||||||||||
non-cash royalty revenue related to the sale of future royalties | 8,040,000 | 6,533,000 | 16,690,000 | 8,488,000 | 9,281,000 | 8,441,000 | 7,242,000 | 7,190,000 | 20,529,000 | 7,613,000 | 6,184,000 | 5,944,000 | 7,380,000 | 6,291,000 | 5,684,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||
research and development support | 855,000 | 455,000 | 109,000 | 73,000 | 758,000 | 388,000 | 6,000 | 4,000 | 11,000 | 5,000 | 5,000 | 7,000 | 51,000 | 17,000 | 218,000 | 388,000 | 388,000 | 383,000 | 2,004,000 | 1,478,000 | 1,354,000 | 1,335,000 | 1,059,000 | 848,000 | 772,000 | 776,000 | 1,922,000 | 1,990,000 | 2,257,000 | 2,036,000 | 1,377,000 | 1,068,000 | 2,005,000 | 1,495,000 | 1,805,000 | 1,283,000 | 782,000 | 3,207,000 | 3,672,000 | 4,473,000 | -18,657,514 | 6,583,000 | 6,593,000 | 5,507,000 | 5,674,000 | 5,258,000 | 5,231,000 | 5,645,000 | 4,572,792 | 4,065,955 | 4,089,008 | 4,059,524 | 3,886,386 | 1,207,681 | |||||||||||
total revenues | 113,425,000 | 83,153,000 | 49,869,000 | 41,167,000 | 15,375,000 | 14,162,000 | 38,078,000 | 27,992,000 | 9,210,000 | 16,948,000 | 15,706,000 | 85,798,000 | 18,189,000 | 15,025,000 | 13,287,000 | 44,864,000 | 13,281,000 | 15,542,000 | 8,584,000 | 13,416,000 | 10,928,000 | 9,287,000 | 19,815,000 | 86,948,000 | 28,499,000 | 7,660,000 | 7,408,000 | 19,714,000 | 18,029,000 | 14,851,000 | 13,203,000 | 30,060,000 | 17,218,000 | 25,001,000 | 2,612,000 | 4,091,000 | 2,536,000 | 4,178,000 | 3,411,000 | 3,314,000 | 3,108,000 | 3,099,000 | 6,126,000 | 9,751,000 | 11,425,000 | -29,639,788 | 9,836,000 | 12,072,000 | 7,770,000 | 8,368,000 | 9,355,000 | 6,587,000 | 7,778,000 | 10,230,493 | 9,047,218 | 9,006,526 | 7,589,612 | 5,163,720 | 3,890,183 | 1,456,470 | 2,476,159 | 2,346,310 | 1,210,334 | 1,544,413 | 1,425,901 |
yoy | 637.72% | 487.16% | 30.97% | 47.07% | 66.94% | -16.44% | 142.44% | -67.37% | -49.37% | 12.80% | 18.21% | 91.24% | 36.96% | -3.33% | 54.79% | 234.41% | 21.53% | 67.35% | -56.68% | -84.57% | -61.65% | 21.24% | 167.48% | 341.05% | 58.07% | -48.42% | -43.89% | -34.42% | 4.71% | -40.60% | 405.47% | 634.78% | 578.94% | 498.40% | -23.42% | 23.45% | -18.40% | 34.82% | -44.32% | -66.01% | -72.80% | -110.46% | -37.72% | -19.23% | 47.04% | -454.20% | 5.14% | 83.27% | -0.10% | -18.21% | 3.40% | -26.86% | 2.48% | 98.12% | 132.57% | 518.38% | 206.51% | 120.08% | 221.41% | -5.69% | 73.66% | ||||
qoq | 36.41% | 66.74% | 21.14% | 167.75% | 8.57% | -62.81% | 36.03% | 203.93% | -45.66% | 7.91% | -81.69% | 371.70% | 21.06% | 13.08% | -70.38% | 237.81% | -14.55% | 81.06% | -36.02% | 22.77% | 17.67% | -53.13% | -77.21% | 205.09% | 272.05% | 3.40% | -62.42% | 9.35% | 21.40% | 12.48% | -56.08% | 74.58% | -31.13% | 857.16% | -36.15% | 61.32% | -39.30% | 22.49% | 2.93% | 6.63% | 0.29% | -49.41% | -37.18% | -14.65% | -138.55% | -401.34% | -18.52% | 55.37% | -7.15% | -10.55% | 42.02% | -15.31% | -23.97% | 13.08% | 0.45% | 18.67% | 46.98% | 32.74% | 167.10% | -41.18% | 5.53% | 93.86% | -21.63% | 8.31% | |
cost and operating expenses: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cost of sales | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
research and development | 47,570,000 | 50,077,000 | 51,620,000 | 58,485,000 | 59,181,000 | 51,422,000 | 44,282,000 | 48,968,000 | 33,147,000 | 34,589,000 | 34,413,000 | 39,578,000 | 24,685,000 | 22,921,000 | 27,408,000 | 26,055,000 | 21,015,000 | 28,559,000 | 38,893,000 | 43,681,000 | 47,243,000 | 38,701,000 | 44,831,000 | 106,851,000 | 32,888,000 | 32,909,000 | 38,652,000 | 36,094,000 | 38,199,000 | 35,132,000 | 28,018,000 | 20,862,000 | 22,029,000 | 21,318,000 | 21,656,000 | 23,700,000 | 17,161,000 | 16,004,000 | 13,425,000 | 12,091,000 | 12,211,000 | 12,188,000 | 11,860,000 | 10,732,000 | 9,105,000 | -11,464,163 | 3,991,000 | 3,846,000 | 11,416,000 | 12,441,000 | 10,216,000 | 8,760,000 | 9,492,000 | 9,819,540 | 6,616,745 | 7,855,096 | 6,169,830 | 5,194,770 | 4,771,367 | 6,295,903 | 6,566,748 | 4,109,351 | 7,173,051 | 3,015,212 | 2,503,556 |
selling, general and administrative | 37,744,000 | 36,356,000 | 40,016,000 | 42,065,000 | 33,623,000 | 23,793,000 | 16,648,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total cost and operating expenses | 87,469,000 | 87,342,000 | 92,262,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
income from operations | 25,956,000 | -4,189,000 | -42,393,000 | -59,559,000 | -77,429,000 | -61,053,000 | -22,852,000 | -34,554,000 | -34,234,000 | -27,369,000 | -28,916,000 | 36,519,000 | -16,727,000 | -18,362,000 | -23,810,000 | 8,494,000 | -17,962,000 | -41,059,000 | -41,646,000 | -40,423,000 | -45,532,000 | -38,752,000 | -36,742,000 | -46,088,000 | -12,894,000 | -38,838,000 | 3,751,000 | -7,089,000 | -7,542,000 | -3,833,000 | -4,599,000 | -5,412,000 | |||||||||||||||||||||||||||||||||
yoy | -133.52% | -93.14% | 85.51% | 72.36% | 126.18% | 123.07% | -20.97% | -194.62% | 104.66% | 49.05% | 21.44% | 329.94% | -6.88% | -55.28% | -42.83% | -121.01% | -60.55% | 5.95% | 13.35% | -12.29% | 253.13% | -0.22% | 30.99% | ||||||||||||||||||||||||||||||||||||||||||
qoq | -719.62% | -90.12% | -28.82% | -23.08% | 26.82% | 167.17% | -33.87% | 0.93% | 25.08% | -5.35% | -179.18% | -318.32% | -8.90% | -22.88% | -380.32% | -147.29% | -56.25% | -1.41% | 3.03% | -11.22% | 17.50% | 5.47% | -20.28% | 257.44% | -66.80% | -6.01% | 96.76% | -16.66% | -15.02% | ||||||||||||||||||||||||||||||||||||
operating margin % | 22.88% | -5.04% | -85.01% | -144.68% | -503.60% | -431.10% | -60.01% | -123.44% | -371.70% | -161.49% | -184.11% | 42.56% | -91.96% | -122.21% | -179.20% | 18.93% | -135.25% | -264.18% | -485.16% | -301.30% | -416.65% | -417.27% | -185.43% | -53.01% | -45.24% | -507.02% | 0% | 0% | 0% | 0% | 0% | 12.48% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | -91.24% | -90.13% | -40.97% | -69.82% | -69.58% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% |
interest income | 7,383,000 | 5,223,000 | 624,250 | 757,000 | 874,000 | 865,000 | 923,000 | 875,000 | 758,000 | 718,000 | 544,655 | 457,176 | 363,947 | 321,739 | 353,305 | 379,372 | 592,466 | 740,814 | 892,407 | 1,084,386 | 1,295,868 | 1,644,937 | |||||||||||||||||||||||||||||||||||||||||||
interest expense on term loan | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
non-cash interest expense on liability related to the sale of future royalties and term loan | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other income | -164,000 | -8,000 | 63,000 | 582,000 | -998,000 | -480,000 | -98,000 | -483,000 | -365,000 | 197,000 | -480,000 | 562,000 | 11,000 | 106,000 | -198,000 | 1,015,000 | -521,000 | 167,000 | -71,000 | -305,000 | -75,000 | -1,052,000 | 537,000 | 1,327,000 | 134,000 | 129,000 | -530,000 | 551,000 | 62,000 | 111,000 | 115,000 | 56,000 | 1,281,000 | 490,000 | 144,000 | 16,000 | 727,000 | 813,000 | 69,000 | -18,000 | -31,000 | -15,000 | 366,000 | 447 | 7,034 | 890 | 30,000 | 593 | 1,409,665 | 12,692 | 1,332 | 3,307 | 26,670 | ||||||||||||
net income before income taxes | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
income tax benefit | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net income | 30,748,000 | -41,014,000 | -40,980,250 | -77,755,000 | -62,021,000 | -24,145,000 | -37,172,000 | -37,339,000 | -30,741,000 | -34,051,000 | 31,388,000 | -22,374,000 | -24,298,000 | -29,088,000 | 4,814,000 | -21,750,000 | -43,446,000 | -43,751,000 | -41,799,000 | -46,807,000 | -41,624,000 | -38,613,000 | -78,667,000 | -17,345,000 | -44,731,000 | -45,922,000 | -31,928,000 | -33,227,000 | -33,740,000 | -22,282,000 | 3,813,000 | -11,226,000 | -1,351,000 | -24,393,000 | -25,192,000 | -19,483,000 | -14,233,000 | -12,888,000 | -12,124,000 | -13,008,000 | -12,375,000 | -9,397,000 | -6,212,000 | -1,032,000 | 14,439,013 | -5,161,000 | -3,044,000 | -6,253,000 | -6,645,000 | -2,981,000 | -3,502,000 | -4,706,000 | -3,550,976 | -2,209,378 | -2,470,506 | -759,921 | -1,332,609 | -4,126,414 | -4,616,581 | -5,285,198 | -3,221,537 | -6,872,868 | -1,732,252 | -1,592,523 | |
yoy | -139.54% | 69.87% | 10.24% | 108.24% | 101.75% | -29.09% | -218.43% | 66.89% | 26.52% | 17.06% | 552.01% | 2.87% | -44.07% | -33.51% | -111.52% | -53.53% | 4.38% | 13.31% | -46.87% | 169.86% | -6.95% | -15.92% | 146.39% | -47.80% | 32.58% | 106.09% | -937.35% | 195.98% | 2397.41% | -8.65% | -115.14% | -42.38% | -90.51% | 89.27% | 107.79% | 49.78% | 15.01% | 37.15% | 95.17% | 1160.47% | -185.71% | 82.08% | 104.07% | -83.50% | -317.29% | 73.13% | -13.08% | 32.87% | 87.13% | 34.92% | 41.75% | 519.27% | 166.47% | -46.46% | -46.49% | -85.62% | -58.63% | -39.96% | 166.51% | 231.88% | |||||
qoq | 0.08% | -47.30% | 25.37% | 156.87% | -35.05% | -0.45% | 21.46% | -9.72% | -208.48% | -240.29% | -7.92% | -16.47% | -704.24% | -122.13% | -49.94% | -0.70% | 4.67% | -10.70% | 12.45% | 7.80% | -50.92% | 353.54% | -61.22% | -2.59% | 43.83% | -3.91% | -1.52% | 51.42% | -684.37% | -133.97% | 730.94% | -94.46% | -3.17% | 29.30% | 36.89% | 10.44% | 6.30% | -6.80% | 5.12% | 31.69% | 51.27% | 501.94% | -107.15% | -379.77% | 69.55% | -51.32% | -5.90% | 122.91% | -14.88% | -25.58% | 32.53% | 60.72% | -10.57% | 225.10% | -42.97% | -67.71% | -10.62% | -12.65% | 64.06% | -53.13% | 296.76% | 8.77% | |||
net income margin % | 27.11% | 0% | -82.24% | -99.55% | -505.72% | -437.94% | -63.41% | -132.80% | -405.42% | -181.38% | -216.80% | 36.58% | -123.01% | -161.72% | -218.92% | 10.73% | -163.77% | -279.54% | -509.68% | -311.56% | -428.32% | -448.20% | -194.87% | -90.48% | -60.86% | -583.96% | -619.90% | -161.96% | -184.30% | -227.19% | -168.76% | 12.68% | -65.20% | -5.40% | -933.88% | -615.79% | -768.26% | -340.67% | -377.84% | -365.84% | -418.53% | -399.32% | -153.40% | -63.71% | -9.03% | -48.71% | -52.47% | -25.22% | -80.48% | -79.41% | -31.87% | -53.17% | -60.50% | -34.71% | -24.42% | -27.43% | -10.01% | -25.81% | -106.07% | -316.97% | -213.44% | -137.30% | -567.85% | -112.16% | -111.69% |
net income per common share - basic | 100 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net income per common share - diluted | 100 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
weighted-average common shares outstanding - basic | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
weighted-average common shares outstanding - diluted | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
income tax expense | 7,000 | 9,000 | 9,000 | 10,000 | 1,000 | 6,000 | 10,000 | 4,949 | 19,628 | 2,872 | 4,207 | 10,290 | 10,290 | 12,850 | 22,275 | 33,000 | 33,000 | 61,812 | |||||||||||||||||||||||||||||||||||||||||||||||
basic and diluted net income per common share | -20 | -160 | -230 | -310 | -240 | -100 | -170 | -180 | -150 | -170 | 190 | -130 | -140 | -170 | 40 | -150 | -290 | -300 | -290 | -320 | -310 | -300 | -780 | -200 | -510 | -530 | -370 | -380 | -390 | -260 | 40 | -130 | -20 | -290 | -300 | -260 | -210 | -190 | -210 | -230 | -220 | -190 | -150 | -20 | 349.55 | -120 | -70 | -150 | -160 | -70 | -90 | -110 | -0.09 | -0.05 | -0.06 | -0.02 | -0.03 | -0.1 | -0.11 | -0.12 | -0.08 | ||||
basic and diluted weighted-average common shares outstanding | 263,446,000 | 258,848,000 | 253,631,000 | 253,511,000 | 253,336,000 | 253,263,000 | 206,147,000 | 204,844,000 | 199,890,000 | 198,835,000 | 176,153,000 | 174,508,000 | 174,354,000 | 166,947,000 | 148,311,000 | 148,479,000 | 148,129,000 | 147,813,000 | 139,946,000 | 147,220,000 | 134,384,000 | 130,619,000 | 98,068,000 | 87,160,000 | 87,102,000 | 86,976,000 | 87,035,000 | 86,838,000 | 85,872,000 | 85,010,000 | 84,279,000 | 84,147,000 | 83,350,000 | 76,364,000 | 67,965,000 | 67,944,000 | 57,365,000 | 57,156,000 | 57,032,000 | 50,783,000 | 42,700,000 | 42,416,000 | 41,759 | 41,705,000 | 41,571,000 | 41,482,000 | 41,184,000 | 41,188,183,000 | 41,079,000 | 41,065,000 | 40,870,768 | 40,800,073 | 40,789,332 | 40,662,750 | 40,597,674 | 40,589,012 | 41,440,747 | 42,773,645 | 42,825,811 | ||||||
investment income | 2,169,000 | 2,158,000 | 1,539,000 | 590,000 | 54,000 | 16,000 | 11,000 | 11,000 | 13,000 | 10,000 | 11,000 | 62,000 | 646,000 | 683,000 | 1,032,000 | 1,287,000 | 1,422,000 | 1,382,000 | 1,369,000 | 814,000 | 662,000 | 1,031,000 | 115,000 | 146,000 | 106,000 | 108,000 | 60,000 | 51,000 | |||||||||||||||||||||||||||||||||||||
non-cash interest expense on liability related to the sale of future royalties | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total comprehensive loss | -41,014,000 | -59,008,000 | -77,755,000 | -62,021,000 | -24,145,000 | -37,172,000 | -37,339,000 | -30,741,000 | -34,051,000 | 31,388,000 | -22,374,000 | -24,298,000 | -29,088,000 | 4,814,000 | -21,750,000 | -43,446,000 | -43,751,000 | -41,799,000 | -46,807,000 | -41,624,000 | -38,613,000 | -78,667,000 | -17,345,000 | -44,731,000 | -45,922,000 | -31,928,000 | -33,740,000 | -22,282,000 | -11,226,000 | ||||||||||||||||||||||||||||||||||||
operating expenses: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total operating expenses | 57,237,250 | 92,804,000 | 75,215,000 | 60,930,000 | 62,546,000 | 43,444,000 | 44,317,000 | 44,622,000 | 49,279,000 | 34,916,000 | 33,387,000 | 37,097,000 | 36,370,000 | 31,243,000 | 56,601,000 | 50,230,000 | 53,839,000 | 56,460,000 | 48,039,000 | 56,557,000 | 133,036,000 | 41,393,000 | 46,498,000 | 47,950,000 | 47,329,000 | 46,253,000 | 43,461,000 | 35,113,000 | 26,309,000 | 28,555,000 | 26,313,000 | 27,120,000 | 29,339,000 | 22,002,000 | 19,692,000 | 16,789,000 | 15,538,000 | 16,097,000 | 15,780,000 | 15,538,000 | 16,685,000 | 13,258,000 | |||||||||||||||||||||||
non-cash interest expense on liability related to the sale of future royalties and convertible senior notes | -3,432,000 | -2,428,000 | -2,546,000 | -2,611,000 | -3,046,000 | -10,107,000 | -3,575,000 | -5,018,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
interest expense on convertible senior notes | -24,000 | -25,000 | -23,000 | -23,000 | -24,000 | -1,915,000 | -1,125,000 | -1,150,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
general and administrative | 13,578,000 | 10,297,000 | 9,728,000 | 10,209,000 | 9,738,000 | 10,231,000 | 9,767,000 | 8,864,000 | 9,803,000 | 9,208,000 | 8,700,000 | 10,778,000 | 9,752,000 | 8,347,000 | 8,652,000 | 9,995,000 | 25,792,000 | 8,119,000 | 9,459,000 | 9,298,000 | 11,235,000 | 8,054,000 | 8,329,000 | 7,095,000 | 5,447,000 | 6,526,000 | 4,995,000 | 5,464,000 | 5,639,000 | 4,841,000 | 3,688,000 | 3,364,000 | 3,447,000 | 3,886,000 | 3,592,000 | 3,678,000 | 3,527,000 | 2,424,000 | -8,199,971 | 2,848,000 | 2,566,000 | 2,797,000 | 2,579,000 | 2,193,000 | 2,332,000 | 2,794,000 | 2,161,167 | 2,033,973 | 1,493,002 | 1,768,550 | 1,412,206 | 1,834,223 | 1,502,253 | 1,296,974 | 1,742,374 | 1,576,469 | 1,242,262 | 1,198,575 | |||||||
restructuring charges | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
restructuring charge | 559,000 | 406,000 | 870,000 | 686,000 | 1,731,000 | 393,000 | 386,000 | 4,130,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
clinical materials revenue | 2,170,000 | 1,427,000 | 336,000 | 702,000 | 3,676,000 | 678,000 | 46,000 | 53,000 | 1,198,000 | 3,000 | 2,325,000 | 2,027,000 | 125,000 | 8,000 | 734,000 | 147,000 | 1,781,000 | ||||||||||||||||||||||||||||||||||||||||||||||||
non-cash debt conversion expense | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
royalty revenue | 195,000 | 4,166,000 | 2,335,000 | 2,053,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic weighted-average common shares outstanding | 86,970,000 | 85,431,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
dilutive impact of potential common shares | 1,845,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
diluted weighted-average common shares outstanding | 86,970,000 | 87,276,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total comprehensive income | -33,227,000 | 3,813,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
comprehensive loss | -1,351,000 | -24,393,000 | -25,192,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
clinical materials reimbursement | 281,000 | 1,307,000 | 106,000 | 243,000 | 998,000 | 486,000 | 696,000 | 3,399,000 | 2,764,000 | -4,658,859 | 1,756,000 | 2,051,000 | 857,000 | 1,354,000 | 822,000 | 81,000 | 831,000 | 2,415,158 | 3,637,099 | 2,865,583 | 936,405 | 226,827 | 1,948,700 | 492,458 | 947,896 | 826,269 | 601,777 | 840,855 | 934,561 | ||||||||||||||||||||||||||||||||||||
income before benefit from income taxes | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
benefit from income taxes | 1,000 | 5,000 | 12,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
income before benefit for income taxes | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
benefit for income taxes | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cost of clinical materials reimbursed | 2,426,000 | 1,729,000 | -3,228,428 | 997,000 | 1,588,000 | 646,000 | 890,000 | 779,000 | 94,000 | 904,000 | 2,285,841 | 3,042,421 | 2,493,937 | 729,050 | 226,826 | 1,758,809 | 439,872 | 843,168 | 752,396 | 556,677 | 840,855 | 934,561 | |||||||||||||||||||||||||||||||||||||||||||
expenses: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preclinical and clinical | 1,556,000 | 2,079,000 | 2,218,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
process and product development | 1,017,250 | 1,391,000 | 1,367,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
manufacturing | 3,336,500 | 4,504,000 | 4,337,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total expenses | 11,648,000 | 15,810,000 | 15,922,000 | 14,859,000 | 15,910,000 | 13,188,000 | 11,186,000 | 13,190,000 | 14,266,548 | 11,693,139 | 11,842,035 | 8,667,430 | 6,833,802 | 8,364,399 | 8,238,028 | 8,706,890 | 6,604,121 | 9,306,197 | 5,098,329 | 4,636,692 | |||||||||||||||||||||||||||||||||||||||||||||
net realized losses on investments | -1,000 | -8,250 | -7,000 | -22,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
gain on sale of assets | 250 | 1,000 | 1,000 | 1,000 | 2,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
income before income tax expense | -6,243,000 | -6,645,000 | -2,980,000 | -3,496,000 | -4,696,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net realized gains on investments | 5,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
development fees | 41,000 | 203,149 | 310,325 | 509,763 | 43,179 | 87,476 | 178,306 | 48,578 | 40,370 | 148,616 | 314,742 | 94,723 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
license fees and milestone payments | 1,033,839 | 1,542,172 | 2,550,504 | 1,050,507 | 646,326 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
revenue earned under collaboration agreements | 785,706 | 1,479,685 | 1,479,671 | 459,941 | 388,816 | 396,617 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
realized gains on investments | 162,846 | 217,569 | 153,450 | 170,277 | 555,289 | 8,473 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net income before income tax expense | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
gain/(loss) on sale of assets | 200 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
income before income tax expense and cumulative effect of change in accounting principle | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
income before cumulative effect of change in accounting principle | -0.17 | -0.04 | -0.04 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cumulative effect of change in accounting principle | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic and diluted net income per common share: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic and diluted average common shares outstanding | 39,829,837 | 39,730,478 | 38,809,948 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss on the sale of assets |
Balance Sheets:
Quarterly
Annual
| Unit: USD | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2017-06-30 | 2016-06-30 | 2016-03-31 | 2015-12-31 | 2015-09-30 | 2014-09-30 | 2013-12-31 | 2013-09-30 | 2013-03-31 | 2012-12-31 | 2012-09-30 | 2011-09-30 | 2010-12-31 | 2010-09-30 | 2010-03-31 | 2009-12-31 | 2009-09-30 | 2008-09-30 | 2007-12-31 | 2007-09-30 | 2007-06-30 | 2007-03-31 | 2006-12-31 | 2006-09-30 | 2006-06-30 | 2006-03-31 | 2005-12-31 | 2005-09-30 | 2005-06-30 | 2005-03-31 | 2004-12-31 | 2004-09-30 | 2004-03-31 | 2003-12-31 | 2003-09-30 | 2003-03-31 | 2002-12-31 | 2002-09-30 | 2002-03-31 | 2001-12-31 | 2001-09-30 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
assets | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents | 605,535,000 | 571,987,000 | 201,249,000 | 275,138,000 | 309,511,000 | 373,874,000 | 437,661,000 | 478,750,000 | 245,761,000 | 239,538,000 | 283,120,000 | 293,856,000 | 188,217,000 | 219,506,000 | 247,299,000 | 176,225,000 | 204,491,000 | 239,825,000 | 270,396,000 | 262,252,000 | 303,205,000 | 345,058,000 | 267,107,000 | 245,026,000 | 182,913,000 | 212,283,000 | 247,843,000 | 121,798,000 | 178,088,000 | 174,838,000 | 206,103,000 | 211,021,000 | 233,614,000 | 179,765,000 | 128,486,000 | 94,942,000 | 41,032,000 | 51,220,000 | 58,641,000 | 31,209,000 | 12,365,000 | 26,275,000 | 10,605 | 7,328,000 | 5,182,000 | 6,276,000 | 4,813,000 | 4,050,000 | 6,688,000 | 2,493,000 | 3,423 | 7,697,106 | 6,925,763 | 6,941,972 | 19,852,750 | 9,533,422 | 5,450,276 | 7,431,161 | 8,985,211 | 15,239,778 | 20,082,436 | 13,844,875 | 16,699,483 |
accounts receivable | 130,694,000 | 75,360,000 | 27,342,000 | 12,596,000 | 42,000 | 909,000 | 1,190,000 | 4,467,000 | 221,000 | 7,000 | 93,000 | 35,000 | 5,050,000 | 313,000 | 54,000 | 7,500,000 | 94,000 | 233,000 | 1,701,000 | 2,115,000 | 19,000 | 883,000 | 104,000 | 803,000 | 6,812,000 | 1,838,000 | 3,818,000 | 5,789,000 | 5,446,000 | 1,286,000 | 853,000 | 1,000 | 1,074,000 | 1,907,000 | 381,000 | 1,981,000 | 2,189,000 | 1,153,000 | 1,743,000 | 2,851,000 | 1,536 | 1,981,000 | 3,193,000 | 2,266,000 | 1,569,000 | 1,500,000 | 1,914,000 | 1,715,000 | 1,418 | 3,369,388 | 1,084,929 | 2,613,580 | 60,991 | 706,360 | 795,680 | 998,456 | 1,155,950 | 2,504,698 | 697,237 | 846,173 | 1,237,480 | ||
unbilled receivable | 3,026,000 | 1,717,000 | 1,249,000 | 1,531,000 | 696,000 | 1,874,000 | 3,643,000 | 2,345,000 | 5,405,000 | 11,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
non-cash royalty receivable | 8,514,000 | 9,249,000 | 8,115,000 | 7,236,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
inventory | 1,938,000 | 1,890,000 | 907,000 | 908,000 | 1,537,000 | 1,246,000 | 2,115,000 | 3,008,000 | 1,671,000 | 112,000 | 450,000 | 170,000 | 1,147,000 | 1,632,000 | 1,500,000 | 1,225,000 | 1,234,000 | 1,372,000 | 1,819,000 | 2,023,000 | 3,088,000 | 3,267 | 2,281,000 | 1,997,000 | 1,920,000 | 1,235,000 | 1,813,000 | 1,787,000 | 824,000 | 1,520 | 1,823,532 | 3,964,999 | 5,266,377 | 8,362,718 | 6,910,264 | 5,592,056 | 4,976,738 | 4,376,095 | 4,116,594 | 3,237,276 | 4,542,803 | 2,891,792 | |||||||||||||||||||||
prepaid and other current assets | 18,712,000 | 14,089,000 | 10,955,000 | 11,005,000 | 16,714,000 | 14,099,000 | 8,807,000 | 7,322,000 | 14,330,000 | 14,504,000 | 15,421,000 | 7,901,000 | 7,875,000 | 6,426,000 | 7,653,000 | 5,425,000 | 4,961,000 | 6,649,000 | 6,710,000 | 4,462,000 | 6,320,000 | 9,893,000 | 4,881,000 | 7,334,000 | 6,618,000 | 4,080,000 | 1,795,000 | 2,321,000 | 3,140,000 | 1,622,000 | 1,976,000 | 2,419,000 | 1,279,000 | 1,356,000 | 1,126,000 | 1,715,000 | 1,161,000 | 973,000 | 508,000 | 2,463,000 | 2,509,000 | 1,571 | 1,611,000 | 1,097,000 | 1,114,000 | 1,298,000 | 1,467,000 | 954,000 | 1,002,000 | 1,398 | 567,170 | 672,185 | 636,510 | 913,032 | 526,045 | 583,711 | 1,124,291 | 1,341,467 | 2,724,833 | 2,075,666 | 1,864,899 | 2,141,077 | |
total current assets | 766,900,000 | 669,273,000 | 243,864,000 | 304,121,000 | 330,416,000 | 393,924,000 | 456,718,000 | 499,999,000 | 270,887,000 | 274,397,000 | 319,572,000 | 324,254,000 | 219,327,000 | 241,371,000 | 270,726,000 | 208,898,000 | 225,681,000 | 259,378,000 | 289,835,000 | 278,781,000 | 322,714,000 | 364,618,000 | 254,780,000 | 193,304,000 | 223,246,000 | 262,016,000 | 128,330,000 | 189,458,000 | 187,736,000 | 215,707,000 | 217,058,000 | 238,821,000 | 183,609,000 | 135,923,000 | 102,235,000 | 48,006,000 | 58,533,000 | 65,953,000 | 51,749,000 | 59,394,000 | 66,688,000 | 72,054 | 76,046,000 | 78,488,000 | 80,678,000 | 84,544,000 | 92,974,000 | 94,452,000 | 96,260,000 | 99,936 | 103,501,685 | 105,115,516 | 108,203,232 | 116,082,691 | 114,024,330 | 116,201,138 | 117,167,482 | 128,369,784 | 136,999,259 | 150,727,677 | 158,701,572 | 159,764,717 | |
property and equipment | 4,431,000 | 3,776,000 | 4,067,000 | 4,377,000 | 4,474,000 | 4,334,000 | 4,431,000 | 4,663,000 | 4,636,000 | 4,957,000 | 5,417,000 | 5,760,000 | 5,578,000 | 5,902,000 | 6,018,000 | 6,993,000 | 9,118,000 | 10,052,000 | 13,720,000 | 12,891,000 | 13,209,000 | 12,029,000 | 22,704,000 | 22,404,000 | 21,518,000 | 18,510,000 | 14,668,000 | 10,753,000 | 10,173,000 | 10,561,000 | 11,352,000 | 11,442,000 | 12,805,000 | 14,825,000 | 15,494,000 | 17,081,000 | 18,081,000 | 19,039,000 | 22,183,000 | 16,495,000 | 8,586,000 | 8,149 | 8,624,000 | 8,837,000 | 9,121,000 | 9,319,000 | 9,503,000 | 9,737,000 | 9,731,000 | 9,883 | 9,950,389 | 9,928,471 | 9,733,916 | 9,697,602 | 9,698,865 | 9,149,657 | 8,750,110 | 8,158,890 | 7,030,110 | 5,882,507 | 4,767,950 | 3,561,909 | |
operating lease right-of-use assets | 16,705,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
inventory, net of current portion | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other assets | 14,159,000 | 14,300,000 | 14,496,000 | 14,011,000 | 13,100,000 | 12,676,000 | 8,672,000 | 8,711,000 | 8,535,000 | 8,886,000 | 7,325,000 | 10,986,000 | 8,570,000 | 7,591,000 | 6,831,000 | 3,784,000 | 3,413,000 | 1,850,000 | 3,665,000 | 3,709,000 | 3,941,000 | 4,437,000 | 3,430,000 | 2,925,000 | 2,942,000 | 911,000 | 108,000 | 400,000 | 203,000 | 183,000 | 196,000 | 174,000 | 141,000 | 189,000 | 162,000 | 226,000 | 36,000 | 42,000 | 32,000 | 12,000 | 12,000 | 218 | 218,000 | 406,000 | 218,000 | 265,000 | 265,000 | 265,000 | 265,000 | 313 | 312,946 | 312,946 | 312,946 | 333,700 | 333,700 | 333,700 | 333,700 | 333,700 | 333,700 | 43,700 | 43,700 | 43,700 | |
total assets | 822,101,000 | 714,327,000 | 288,345,000 | 348,936,000 | 358,799,000 | 422,295,000 | 481,709,000 | 525,765,000 | 296,803,000 | 301,446,000 | 345,962,000 | 355,072,000 | 247,952,000 | 269,728,000 | 298,809,000 | 235,262,000 | 254,136,000 | 287,669,000 | 323,925,000 | 295,381,000 | 339,864,000 | 381,084,000 | 294,676,000 | 287,085,000 | 222,347,000 | 251,580,000 | 285,584,000 | 143,106,000 | 202,523,000 | 200,024,000 | 228,682,000 | 230,837,000 | 252,668,000 | 199,104,000 | 153,805,000 | 120,759,000 | 69,200,000 | 80,537,000 | 88,921,000 | 78,424,000 | 79,773,000 | 79,158,000 | 80,421 | 84,888,000 | 87,731,000 | 90,017,000 | 94,128,000 | 102,742,000 | 104,454,000 | 106,256,000 | 110,132 | 113,765,020 | 115,356,933 | 118,250,094 | 126,113,993 | 124,056,895 | 125,684,495 | 126,352,023 | 137,675,818 | 146,213,069 | 156,653,884 | 163,513,222 | 163,370,326 |
liabilities and shareholders’ equity | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts payable | 24,853,000 | 18,441,000 | 32,260,000 | 45,353,000 | 20,178,000 | 17,245,000 | 16,060,000 | 18,434,000 | 10,520,000 | 11,631,000 | 12,916,000 | 9,538,000 | 8,913,000 | 12,739,000 | 9,534,000 | 9,933,000 | 7,227,000 | 7,809,000 | 8,777,000 | 11,365,000 | 10,352,000 | 12,881,000 | 11,510,000 | 10,100,000 | 13,404,000 | 9,689,000 | 4,957,000 | 3,812,000 | 3,122,000 | 2,723,000 | 4,706,000 | 3,216,000 | 2,850,000 | 1,769,000 | 1,092,000 | 1,280,000 | 1,981,000 | 1,051,000 | 1,720,000 | 2,168,000 | 1,892,000 | 2,226 | 2,202,000 | 1,093,000 | 1,869,000 | 1,346,000 | 1,477,000 | 940,000 | 1,352,000 | 2,099 | 3,278,550 | 1,673,579 | 1,598,984 | 2,473,991 | 1,231,337 | 1,282,398 | 2,725,212 | 979,571 | 573,442 | 2,183,612 | 1,461,188 | 860,290 | |
accrued compensation | 15,155,000 | 10,734,000 | 11,780,000 | 11,111,000 | 8,621,000 | 4,960,000 | 3,408,000 | 5,469,000 | 4,718,000 | 3,599,000 | 2,882,000 | 4,620,000 | 3,942,000 | 4,321,000 | 5,211,000 | 8,991,000 | 13,232,000 | 19,564,000 | 4,423,000 | 11,796,000 | 10,316,000 | 8,524,000 | 10,724,000 | 6,589,000 | 5,455,000 | 3,262,000 | 3,712,000 | 4,162,000 | 3,276,000 | 5,063,000 | 3,173,000 | 2,436,000 | 2,306,000 | 2,461,000 | 1,837,000 | 3,228,000 | 2,181,000 | 1,727,000 | 1,481,000 | 2,355,000 | 1,357,000 | 1,213 | 2,770,000 | 2,321,000 | 1,146,000 | 925,000 | 1,946,000 | 2,019,000 | 1,027,000 | 728 | 2,584,289 | 1,698,700 | 1,308,141 | 1,943,632 | 1,155,953 | 924,946 | 528,051 | 348,805 | 457,249 | 1,686,335 | 1,216,130 | 1,080,248 | |
other accrued liabilities | 43,571,000 | 36,292,000 | 30,918,000 | 38,783,000 | 47,136,000 | 36,588,000 | 28,730,000 | 23,077,000 | 34,718,000 | 29,185,000 | 32,820,000 | 29,320,000 | 21,114,000 | 15,363,000 | 18,916,000 | 13,932,000 | 14,040,000 | 14,681,000 | 20,629,000 | 20,465,000 | 24,117,000 | 17,865,000 | 9,713,000 | 9,150,000 | 7,718,000 | 9,631,000 | 6,844,000 | 6,158,000 | 6,904,000 | 6,337,000 | 4,467,000 | 7,421,000 | 3,236,000 | 2,495,000 | 2,253,000 | 2,429,000 | 2,665,000 | 2,284,000 | 3,064,000 | 2,133,000 | 2,024,000 | 4,476 | 4,259,000 | 3,983,000 | 3,470,000 | ||||||||||||||||||
current portion of liability related to the sale of future royalties, net of deferred financing costs of 128 and 162, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of operating lease liability | 2,634,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of deferred revenue | 37,186,000 | 14,389,000 | 13,444,000 | 13,856,000 | 15,079,000 | 15,636,000 | 23,417,000 | 44,351,000 | 53,526,000 | 53,792,000 | 51,515,000 | 29,249,000 | 3,985,000 | 80,000 | 123,000 | 309,000 | 14,817,000 | 317,000 | 317,000 | 317,000 | 1,713,000 | 1,020,000 | 13,582,000 | 339,000 | 1,545,000 | 858,000 | 23,699,000 | 2,522,000 | 2,260,000 | 1,712,000 | 1,303,000 | 1,376,000 | 3,848,000 | 3,034,000 | 3,545,000 | 3,459,000 | 3,769,000 | 3,901,000 | 2,909,000 | 6,249,000 | 7,453,000 | 6,373 | 5,121,000 | 5,418,000 | 5,879,000 | 5,323,000 | 6,661,000 | 6,076,000 | 5,456,000 | 5,072 | 4,279,077 | 4,386,084 | 5,859,802 | 7,272,509 | 6,447,384 | 4,585,933 | 1,835,925 | 2,217,603 | 1,905,585 | 2,000,481 | 1,804,201 | 1,601,965 | |
total current liabilities | 134,660,000 | 93,702,000 | 101,629,000 | 121,858,000 | 103,642,000 | 87,071,000 | 84,118,000 | 100,945,000 | 111,785,000 | 120,319,000 | 134,353,000 | 122,323,000 | 99,821,000 | 90,879,000 | 85,506,000 | 77,410,000 | 88,174,000 | 74,616,000 | 61,426,000 | 70,660,000 | 70,370,000 | 63,348,000 | 61,439,000 | 39,830,000 | 43,900,000 | 35,948,000 | 39,774,000 | 17,633,000 | 16,541,000 | 16,814,000 | 14,628,000 | 15,428,000 | 13,219,000 | 10,738,000 | 9,706,000 | 11,375,000 | 11,575,000 | 9,942,000 | 10,153,000 | 13,364,000 | 12,726,000 | 14,288 | 14,352,000 | 12,815,000 | 12,364,000 | 10,723,000 | 12,579,000 | 10,966,000 | 9,436,000 | 9,226 | 11,333,976 | 8,690,967 | 10,381,191 | 14,310,097 | 10,753,823 | 8,642,300 | 6,654,835 | 8,398,258 | 7,160,017 | 6,998,325 | 9,056,425 | 5,374,499 | |
senior secured term loan | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred revenue, net of current portion | 26,718,000 | 30,217,000 | 34,055,000 | 36,355,000 | 38,732,000 | 43,611,000 | 46,694,000 | 47,717,000 | 52,479,000 | 55,480,000 | 58,522,000 | 80,860,000 | 126,541,000 | 126,535,000 | 127,387,000 | 127,123,000 | 131,035,000 | 145,614,000 | 145,693,000 | 80,485,000 | 80,592,000 | 80,751,000 | 19,288,000 | 32,015,000 | 32,041,000 | 40,794,000 | 34,661,000 | 46,487,000 | 55,275,000 | 63,297,000 | 70,365,000 | 69,769,000 | 50,856,000 | 52,652,000 | 8,074,000 | 9,245,000 | 9,782,000 | 9,592,000 | 7,606,000 | 6,863,000 | 7,103,000 | 7,402 | 10,297,000 | 10,705,000 | 11,368,000 | 12,988,000 | 11,817,739 | 11,444,347 | |||||||||||||||
operating lease liability, net of current portion | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liability related to the sale of future royalties, net of current portion and deferred financing costs of 111 and 205, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other long-term liabilities | 2,800,000 | 300,000 | 300,000 | 300,000 | 300,000 | 466,000 | 676,000 | 1,306,000 | 2,079,000 | 2,442,000 | 2,480,000 | 2,586,000 | 2,818,000 | 2,587,000 | 1,489,000 | 707,000 | 970,000 | 1,943,000 | 473,000 | 4,180,000 | 4,193,000 | 4,231,000 | 4,192,000 | 4,173,000 | 4,171,000 | 4,127,000 | 3,796,000 | 3,230,000 | 3,385,000 | 3,698,000 | 3,733,000 | 3,799,000 | 3,919,000 | 4,165,000 | 4,141,000 | 3,822,000 | 3,810,000 | 3,737,000 | 3,029,000 | 1,237,000 | 1,268,000 | 330 | 297,000 | 286,000 | 371,000 | 350,000 | 374,000 | 365,000 | |||||||||||||||
total liabilities | 260,505,000 | 223,485,000 | 166,427,000 | 193,110,000 | 180,792,000 | 172,464,000 | 175,241,000 | 200,179,000 | 219,710,000 | 232,981,000 | 251,842,000 | 265,502,000 | 290,843,000 | 294,251,000 | 302,912,000 | 311,383,000 | 340,361,000 | 355,843,000 | 351,529,000 | 284,409,000 | 292,976,000 | 291,894,000 | 369,389,000 | 263,490,000 | 268,266,000 | 273,975,000 | 84,135,000 | 72,487,000 | 80,583,000 | 89,680,000 | 94,842,000 | 95,356,000 | 75,333,000 | 75,628,000 | 30,238,000 | 33,249,000 | 34,218,000 | 32,567,000 | 31,062,000 | 26,636,000 | 21,097,000 | 22,020 | 23,087,000 | 22,819,000 | 23,032,000 | 21,778,000 | 24,321,000 | 24,319,000 | 23,285,000 | 23,290 | 24,359,318 | 22,865,020 | 23,604,558 | 29,492,805 | 26,797,634 | 27,182,366 | 16,585,499 | 18,741,242 | 18,141,752 | 18,826,070 | 20,506,772 | 16,339,897 | |
commitments and contingencies | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
shareholders’ equity: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, .01 par value... | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
common stock, .01 par value... | 2,435,000 | 2,374,000 | 2,261,000 | 2,260,000 | 2,208,000 | 2,206,000 | 2,205,000 | 2,204,000 | 2,024,000 | 2,003,000 | 1,999,000 | 1,950,000 | 1,746,000 | 1,745,000 | 1,743,000 | 853,000 | 844,000 | 842,000 | 841,000 | 764,000 | 680,000 | 680,000 | 574,000 | 573,000 | 571,000 | 508,000 | 429,000 | 425,000 | 423 | 422,000 | 416,000 | 452,000 | 451,000 | 451,000 | 448,000 | 448,000 | 447 | 446,809 | 445,021 | 444,649 | 443,763 | 442,913 | 442,648 | 442,572 | 442,554 | 400,201 | 397,689 | 396,854 | |||||||||||||||
additional paid-in capital | 2,267,747,000 | 2,227,802,000 | 1,854,743,000 | 1,847,638,000 | 1,810,863,000 | 1,804,934,000 | 1,799,551,000 | 1,794,525,000 | 1,509,040,000 | 1,463,094,000 | 1,458,012,000 | 1,419,460,000 | 1,318,591,000 | 1,314,586,000 | 1,310,710,000 | 1,209,846,000 | 1,204,559,000 | 1,200,860,000 | 1,197,988,000 | 1,192,813,000 | 1,186,934,000 | 1,182,429,000 | 770,511,000 | 765,751,000 | 758,281,000 | 753,349,000 | 728,525,000 | 713,361,000 | 706,581,000 | 693,050,000 | 688,694,000 | 685,619,000 | 573,127,000 | 476,981,000 | 475,092,000 | 394,100,000 | 392,433,000 | 389,565,000 | 345,868,000 | 317,696,000 | 316,335,000 | 315 | 314,452,000 | 312,462,000 | 322,494,000 | 321,885,000 | 321,187,000 | 319,766,000 | 319,140,000 | 318,300 | 318,255,236 | 317,848,497 | 317,708,580 | 317,283,894 | 317,149,342 | 317,048,421 | 317,045,447 | 317,034,138 | 317,025,491 | 316,672,814 | 314,472,119 | ||
accumulated deficit | -1,708,586,000 | -1,739,334,000 | -1,735,086,000 | -1,694,072,000 | -1,635,064,000 | -1,557,309,000 | -1,495,288,000 | -1,471,143,000 | -1,433,971,000 | -1,396,632,000 | -1,365,891,000 | -1,331,840,000 | -1,363,228,000 | -1,340,854,000 | -1,316,556,000 | -1,287,468,000 | -1,292,282,000 | -1,270,532,000 | -1,227,086,000 | -1,183,335,000 | -1,141,536,000 | -1,094,729,000 | -853,687,000 | -244,814,000 | -238,561,000 | -231,916,000 | -228,935,000 | -225,433,000 | |||||||||||||||||||||||||||||||||||
total shareholders’ equity | 561,596,000 | 490,842,000 | 121,918,000 | 155,826,000 | 178,007,000 | 249,831,000 | 306,468,000 | 325,586,000 | 77,093,000 | 68,465,000 | 94,120,000 | 89,570,000 | 10,972,000 | 46,888,000 | 89,190,000 | 11,609,000 | 58,971,000 | 130,036,000 | 119,441,000 | 139,002,000 | 135,995,000 | 157,312,000 | 123,771,000 | 78,177,000 | 90,521,000 | 35,951,000 | 46,319,000 | 56,354,000 | 53,137,000 | 58,061,000 | |||||||||||||||||||||||||||||||||
total liabilities and shareholders’ equity | 822,101,000 | 714,327,000 | 288,345,000 | 348,936,000 | 358,799,000 | 422,295,000 | 481,709,000 | 525,765,000 | 296,803,000 | 301,446,000 | 345,962,000 | 355,072,000 | 295,381,000 | 339,864,000 | 381,084,000 | 222,347,000 | 251,580,000 | 285,584,000 | 143,106,000 | 202,523,000 | 200,024,000 | 228,682,000 | 230,837,000 | 252,668,000 | 199,104,000 | 153,805,000 | 120,759,000 | 69,200,000 | 80,537,000 | 88,921,000 | 79,773,000 | 79,158,000 | |||||||||||||||||||||||||||||||
current portion of liability related to the sale of future royalties, net of deferred financing costs of 143 and 162, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liability related to the sale of future royalties, net of current portion and deferred financing costs of 136 and 205, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of liability related to the sale of future royalties, net of deferred financing costs of 150 and 162, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liability related to the sale of future royalties, net of current portion and deferred financing costs of 172 and 205, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
contract assets | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of liability related to the sale of future royalties, net of deferred financing costs of 162 and 198, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liability related to the sale of future royalties, net of current portion and deferred financing costs of 205 and 381, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of liability related to the sale of future royalties, net of deferred financing costs of 175 and 198, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liability related to the sale of future royalties, net of current portion and deferred financing costs of 241 and 381, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of liability related to the sale of future royalties, net of deferred financing costs of 187 and 198, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liability related to the sale of future royalties, net of current portion and deferred financing costs of 282 and 381, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of liability related to the sale of future royalties, net of deferred financing costs of 199 and 198, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liability related to the sale of future royalties, net of current portion and deferred financing costs of 323 and 381, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible 4.5% senior notes, net of deferred financing costs of 0 and 7, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of liability related to the sale of future royalties, net of deferred financing costs of 198 and 319, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liability related to the sale of future royalties, net of current portion and deferred financing costs of 381 and 584, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
unbilled receivables | 4,706,000 | 4,227,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of liability related to the sale of future royalties, net of deferred financing costs of 206 and 319, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liability related to the sale of future royalties, net of current portion and deferred financing costs of 427 and 584, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of liability related to the sale of future royalties, net of deferred financing costs of 231 and 319, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liability related to the sale of future royalties, net of current portion and deferred financing costs of 473 and 584, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible 4.5% senior notes, net of deferred financing costs of 4 and 7, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of liability related to the sale of future royalties, net of deferred financing costs of 267 and 319, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liability related to the sale of future royalties, net of current portion and deferred financing costs of 525 and 584, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
shareholders’ deficit: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible 4.5% senior notes, net of deferred financing costs of 7 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of liability related to the sale of future royalties, net of deferred financing costs of 319 and 635, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible 4.5% senior notes, net of deferred financing costs of 22 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liability related to the sale of future royalties, net of current portion and deferred financing costs of 584 and 859, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
unbilled revenue/reimbursement | 5,000 | 5,000 | 1,753,000 | 1,001,000 | 3,009,000 | 2,474,000 | 3,982,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liabilities and shareholders’ deficit | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible 4.5% senior notes, net of deferred financing costs of 11 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of liability related to the sale of future royalties, net of deferred financing costs of 402 and 635, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liability related to the sale of future royalties, net of current portion and deferred financing costs of 625 and 859, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total shareholders’ deficit | -42,891,000 | -24,523,000 | -4,103,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total liabilities and shareholders’ deficit | 247,952,000 | 269,728,000 | 298,809,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of liability related to the sale of future royalties, net of deferred financing costs of 470 and 635, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible 4.5% senior notes, net of deferred financing costs of 15 and 22, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liability related to the sale of future royalties, net of current portion and deferred financing costs of 699 and 859, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of liability related to the sale of future royalties, net of deferred financing costs of 557 and 635, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible 4.5% senior notes, net of deferred financing costs of 18 and 22, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liability related to the sale of future royalties, net of current portion and deferred financing costs of 765 and 859, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
contract asset | 500,000 | 500,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liabilities and shareholders’ (deficit) equity | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of deferred lease incentive | 837,000 | 832,000 | 793,000 | 772,000 | 651,000 | 646,000 | 646,000 | 562,000 | 979,000 | 979,000 | 979,000 | 979,000 | 979,000 | 979,000 | 979,000 | 979,000 | 979,000 | 979,000 | 979,000 | 979,000 | |||||||||||||||||||||||||||||||||||||||||||
current portion of liability related to the sale of future royalties, net of deferred financing costs of 635 and 753, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred lease incentive, net of current portion | 4,675,000 | 4,854,000 | 4,806,000 | 6,236,000 | 5,836,000 | 5,978,000 | 6,139,000 | 5,904,000 | 5,137,000 | 5,382,000 | 5,871,000 | 6,116,000 | 6,360,000 | 7,339,000 | 8,073,000 | 8,317,000 | 8,807,000 | 9,051,000 | 9,296,000 | 10,274,000 | |||||||||||||||||||||||||||||||||||||||||||
operating lease liability - net of current portion | 24,084,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible 4.5% senior notes, net of deferred financing costs of 22 and 36, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liability related to the sale of future royalties, net of current portion and deferred financing costs of 859 and 1,536, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
common stock, 0.01 par value... | 1,501,000 | 1,498,000 | 1,498,000 | 1,494,000 | 1,494,000 | 1,490,000 | 1,490,000 | 872,000 | 871,000 | 870,000 | 870,000 | 859,000 | 856,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||
total shareholders’ (deficit) equity | -76,121,000 | -86,225,000 | -68,174,000 | -27,604,000 | -82,304,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total liabilities and shareholders’ (deficit) equity | 235,262,000 | 254,136,000 | 287,669,000 | 323,925,000 | 287,085,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of liability related to the sale of future royalties, net of deferred financing costs of 707 and 753, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible 4.5% senior notes, net of deferred financing costs of 25 and 36, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liability related to the sale of future royalties, net of current portion and deferred financing costs of 977 and 1,536, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of liability related to the sale of future royalties, net of deferred financing costs of 715 and 753, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible 4.5% senior notes, net of deferred financing costs of 29 and 36, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liability related to the sale of future royalties, net of current portion and deferred financing costs of 1,175 and 1,536, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of liability related to the sale of future royalties, net of deferred financing costs of 590 and 753, respectively | 24,646,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible 4.5% senior notes, net of deferred financing costs of 32 and 36, respectively | 2,068,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liability related to the sale of future royalties, net of current portion and deferred financing costs of 1,500 and 1,536, respectively | 117,785,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
unbilled revenue | 617,000 | 521,000 | 522,000 | 1,409,000 | 1,027,000 | 885,000 | 899,000 | 784,000 | 1,904,000 | 1,979,000 | 2,105,000 | 2,006,000 | 1,446,000 | 1,098,000 | 2,356,000 | 1,741,000 | 1,894,000 | 1,150,000 | 975,000 | 3,351,000 | 4,239,000 | 4,369,000 | 5,980 | 6,150,000 | 5,519,000 | 5,102,000 | 5,419,000 | 5,429,000 | 4,797,000 | 5,895,000 | 5,035 | 6,171,548 | 6,057,787 | 4,666,436 | 4,955,562 | 5,206,970 | 1,887,276 | 267,020 | 628,372 | 470,958 | 715,504 | ||||||||||||||||||||||
current portion of liability related to the sale of future royalties, net of deferred financing costs of 753 and 772, respectively | 25,880,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible 4.5% senior notes, net of deferred financing costs of 36 and 50, respectively | 2,064,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liability related to the sale of future royalties, net of current portion and deferred financing costs of 1,536 and 2,373, respectively | 122,345,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of liability related to the sale of future royalties, net of deferred financing costs of 759 and 772, respectively | 23,040,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible 4.5% senior notes, net of deferred financing costs of 40 and 50, respectively | 2,060,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liability related to the sale of future royalties, net of current portion and deferred financing costs of 1,739 and 2,373, respectively | 130,907,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of liability related to the sale of future royalties, net of deferred financing costs of 788 and 772, respectively | 22,265,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible 4.5% senior notes, net of deferred financing costs of 43 and 50, respectively | 2,057,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liability related to the sale of future royalties, net of current portion and deferred financing costs of 1,918 and 2,373, respectively | 136,701,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
consolidated statement of operations data: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total revenues | 115,447,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total operating expenses | 174,429,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
non-cash interest expense on liability related to sale of future royalty and convertible senior notes | 13,682,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
non-cash debt conversion expense | 22,915,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other income | -433,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net income | -96,012,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic and diluted net income per common share | -980 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic and diluted weighted-average common shares outstanding | 98,068,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
consolidated balance sheet data: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term convertible notes - net | 2,050,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
shareholders’ (deficit) equity | -17,895,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of deferred financing costs | 1,674,000 | 1,018,000 | 1,120,000 | 1,136,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred financing costs, net of current portion | 6,171,000 | 3,714,000 | 3,874,000 | 4,147,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of liability related to the sale of future royalties | 15,138,000 | 13,001,000 | 15,132,000 | 11,862,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible 4.5% senior notes | 100,000,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liability related to the sale of future royalties, net of current portion | 178,234,000 | 181,636,000 | 182,176,000 | 186,967,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
shareholders’ (deficit) equity: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.01 par value... | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
restricted cash | 319,000 | 319,000 | 319,000 | 319,000 | 319,000 | 319,000 | 1,019,000 | 1,019,000 | 574,000 | 574,000 | 574,000 | 366,000 | 268,000 | 268,000 | |||||||||||||||||||||||||||||||||||||||||||||||||
long-term restricted cash | 1,912,000 | 1,912,000 | 2,231,000 | 2,231,000 | 2,231,000 | 2,549,000 | 2,868,000 | 2,868,000 | 3,887,000 | 3,887,000 | 3,887,000 | 4,460,000 | 3,872,000 | 3,872,000 | |||||||||||||||||||||||||||||||||||||||||||||||||
marketable securities | 1,185,000 | 1,213,000 | 1,229,000 | 13,343,000 | 36,293,000 | 27,328,000 | 49,095 | 56,695,000 | 61,500,000 | 64,000,000 | 70,210,000 | 78,715,000 | 78,312,000 | 84,331,000 | 87,142 | 83,872,941 | 86,409,853 | 88,078,357 | 81,937,638 | 91,141,269 | 101,892,139 | 102,369,816 | 111,882,689 | 111,942,398 | 123,919,558 | 137,223,913 | 135,732,305 | ||||||||||||||||||||||||||||||||||||
accumulated other comprehensive income | 235,000 | 147,000 | 44,000 | 72,861 | 56,200 | 67,645 | 208,123 | 500,132 | 823,984 | 199,049 | 708,024 | 1,254,778 | |||||||||||||||||||||||||||||||||||||||||||||||||||
liabilities and stockholders’ equity | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stockholders’ equity: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accumulated other comprehensive loss | -76,000 | -354,000 | -230,000 | -73,000 | -113,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total stockholders’ equity | 47,362,000 | 58,401 | 61,801,000 | 64,912,000 | 66,985,000 | 72,350,000 | 78,421,000 | 80,135,000 | 82,971,000 | 86,842 | 89,405,702 | 92,491,913 | 94,645,536 | 96,621,188 | 97,259,261 | 98,502,129 | 109,766,524 | 118,934,576 | 128,071,317 | 137,827,814 | 143,006,450 | 147,030,429 | |||||||||||||||||||||||||||||||||||||||||
total liabilities and stockholders’ equity | 78,424,000 | 80,421 | 84,888,000 | 87,731,000 | 90,017,000 | 94,128,000 | 102,742,000 | 104,454,000 | 106,256,000 | 110,132 | 113,765,020 | 115,356,933 | 118,250,094 | 126,113,993 | 124,056,895 | 125,684,495 | 126,352,023 | 137,675,818 | 146,213,069 | 156,653,884 | 163,513,222 | 163,370,326 | |||||||||||||||||||||||||||||||||||||||||
current portion of lease incentive obligation | 459,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
lease incentive obligation, net of current portion | 5,172,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term portion deferred revenue | 8,438,000 | 9,718,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
treasury stock | -11,071,000 | -11,071,000 | -11,071,000 | -11,071,000 | -11,071,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other current accrued liabilities | 3,129,000 | 2,495,000 | 1,931,000 | 1,601,000 | 1,327 | 1,192,060 | 932,604 | 1,614,264 | 2,619,965 | 1,919,149 | 1,849,023 | 1,565,647 | 4,852,279 | 4,223,741 | 1,127,897 | 4,572,086 | 1,826,466 | ||||||||||||||||||||||||||||||||||||||||||||||
deferred compensation | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred revenue | 13,430,000 | 13,739 | 12,723,967 | 13,750,860 | 12,930,531 | 14,956,540 | 15,969,543 | 18,482,552 | 9,908,536 | 10,321,527 | 10,965,580 | 10,965,398 | |||||||||||||||||||||||||||||||||||||||||||||||||||
other long term liabilities | 419,000 | 325 | 301,375 | 423,193 | 292,836 | 226,168 | 74,268 | 57,514 | 22,128 | 21,457 | 16,155 | 10,006 | 6,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||
deposit on construction in progress | 100,731 | 813,444 | 1,850,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
shares and 40,155,560 shares as of september 30, 2002 and june 30, 2002, respectively | 442,539 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long term marketable securities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of capital lease obligations | 2,820 | 5,530 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
earned and unbilled revenue | 378,909 | 1,062,580 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liabilities and stockholders' equity | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stockholders' equity: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
additional paid–in capital | 316,217,927 |
Cashflow Statements:
Quarterly
Annual
| Unit: USD | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2017-03-31 | 2016-09-30 | 2016-06-30 | 2016-03-31 | 2015-12-31 | 2015-09-30 | 2014-09-30 | 2013-12-31 | 2013-09-30 | 2013-03-31 | 2012-12-31 | 2012-09-30 | 2011-09-30 | 2010-12-31 | 2010-09-30 | 2010-03-31 | 2009-12-31 | 2009-09-30 | 2008-09-30 | 2007-12-31 | 2007-09-30 | 2007-06-30 | 2007-03-31 | 2006-12-31 | 2006-09-30 | 2006-06-30 | 2006-03-31 | 2005-12-31 | 2005-09-30 | 2005-06-30 | 2005-03-31 | 2004-12-31 | 2004-09-30 | 2004-03-31 | 2003-12-31 | 2003-09-30 | 2003-03-31 | 2002-12-31 | 2002-09-30 | 2002-03-31 | 2001-12-31 | 2001-09-30 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash flows from operating activities: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net income | 30,748,000 | -4,248,000 | -41,014,000 | -59,008,000 | -77,755,000 | -62,021,000 | -24,145,000 | -37,172,000 | -37,339,000 | -30,741,000 | -34,051,000 | 31,388,000 | -22,374,000 | -24,298,000 | -29,088,000 | 4,814,000 | -21,750,000 | -43,446,000 | -43,751,000 | -46,807,000 | -41,624,000 | -38,613,000 | -17,345,000 | -44,731,000 | -45,922,000 | -31,928,000 | -33,227,000 | -33,740,000 | -22,282,000 | 3,812,000 | -11,226,000 | -1,351,000 | -24,393,000 | -25,192,000 | -19,483,000 | -14,233,000 | -12,888,000 | -12,124,000 | -13,008,000 | -12,375,000 | -9,397,000 | -6,212,000 | -1,032,000 | -5,160,000 | -3,045,000 | -6,253,000 | -2,981,000 | -3,502,000 | -4,706,000 | 8,219,909 | -3,550,976 | -2,209,378 | -2,470,506 | -759,921 | -1,332,609 | -4,126,414 | -4,616,581 | -5,285,198 | -3,221,537 | -6,872,868 | -1,732,252 | -1,592,523 | |||
adjustments to reconcile net income to net cash from operating activities: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
non-cash royalty revenue related to sale of future royalties | -8,488,000 | -8,441,000 | -7,242,000 | -7,190,000 | -7,613,000 | -6,184,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
non-cash interest expense on liability related to sale of future royalties | 5,018,000 | 4,972,000 | 5,059,000 | 5,143,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
non-cash interest expense on amortization of debt discount and issuance costs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
depreciation and amortization | 423,000 | 427,000 | 448,000 | 428,000 | 424,000 | 458,000 | 473,000 | 462,000 | 462,000 | 542,000 | 551,000 | 532,000 | 524,000 | 516,000 | 529,000 | 751,000 | 839,000 | 1,238,000 | 1,200,000 | 1,136,000 | 2,529,000 | 2,527,000 | 1,506,000 | 1,528,000 | 1,505,000 | 1,435,000 | 1,260,000 | 1,127,000 | 1,389,000 | 1,145,000 | 1,162,000 | 1,173,000 | 1,162,000 | 1,174,000 | 1,163,000 | 1,198,000 | 1,178,000 | 1,188,000 | 1,214,000 | 1,258,000 | 1,233,000 | 1,062,000 | 1,049,000 | -2,120,847 | 722,000 | 711,000 | 691,000 | 664,000 | 692,000 | 682,000 | 650,000 | -1,622,634 | 605,650 | 578,485 | 440,721 | 358,808 | 322,250 | 229,287 | 321,537 | 302,361 | 285,072 | 247,708 | 246,551 | 228,225 | |
stock and deferred share unit compensation | 7,874,000 | 7,433,000 | 7,067,000 | 10,753,000 | 5,482,000 | 4,973,000 | 4,407,000 | 6,433,000 | 3,477,000 | 3,742,000 | 3,823,000 | 3,867,000 | 3,878,000 | 3,454,000 | 3,122,000 | 3,228,000 | 3,626,000 | 2,206,000 | 5,107,000 | 4,410,000 | 4,025,000 | 3,847,000 | 2,665,000 | 4,497,000 | 4,580,000 | 7,283,000 | 4,602,000 | 5,783,000 | 5,410,000 | 3,753,000 | 4,795,000 | 2,991,000 | 2,928,000 | 3,920,000 | 2,568,000 | 1,582,000 | 1,478,000 | 1,096,000 | 1,241,000 | 1,104,000 | 1,355,000 | 585,000 | |||||||||||||||||||||||
change in operating assets and liabilities: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts receivable | -55,334,000 | -48,018,000 | -14,746,000 | -12,554,000 | 867,000 | 281,000 | 3,277,000 | -4,246,000 | -214,000 | 86,000 | -58,000 | 5,015,000 | -4,737,000 | -259,000 | 7,446,000 | -7,406,000 | -94,000 | 233,000 | 1,468,000 | 1,167,000 | -2,096,000 | 15,000 | 2,615,000 | -1,867,000 | 567,000 | -779,000 | 699,000 | 58,000 | 4,667,000 | -697,000 | -70,000 | 415,000 | -199,000 | -297,000 | -1,492,688 | -2,284,459 | 1,528,651 | 2,251,942 | 157,494 | ||||||||||||||||||||||||||
unbilled receivable | -1,309,000 | -468,000 | 282,000 | -835,000 | 1,178,000 | 1,769,000 | -1,298,000 | 2,361,000 | -479,000 | 1,178,000 | -5,394,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
inventory | -12,554,000 | -4,309,000 | -709,000 | -48,000 | -1,522,000 | 670,000 | -1,033,000 | -1,120,000 | 1,000 | 629,000 | -291,000 | 1,689,000 | 835,000 | 338,000 | -280,000 | 1,118,000 | 9,000 | 138,000 | 464,000 | 297,000 | 1,065,000 | 179,000 | -686,000 | 198,000 | -14,000 | -748,000 | 696,000 | -4,809,406 | 2,141,457 | 1,301,378 | 1,371,689 | 28,657 | |||||||||||||||||||||||||||||||||
contract asset | 500,000 | 1,000,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
prepaid and other current assets | -4,623,000 | -3,134,000 | 50,000 | 5,709,000 | -2,615,000 | -5,292,000 | -1,485,000 | 7,008,000 | 174,000 | 917,000 | -7,520,000 | -26,000 | -1,449,000 | 1,227,000 | -2,228,000 | -464,000 | 1,688,000 | 61,000 | -2,248,000 | 7,815,000 | 3,573,000 | -4,213,000 | -2,713,000 | -1,008,000 | -2,600,000 | 95,000 | 525,000 | 297,000 | 1,374,000 | -255,000 | 513,000 | -189,000 | 256,000 | 1,024,000 | 30,000 | 184,000 | 170,000 | -514,000 | 48,000 | 396,000 | 105,015 | -35,675 | 189,701 | -386,987 | 57,666 | 395,012 | 217,176 | -210,767 | 276,178 | 83,310 | |||||||||||||||
operating lease right-of-use assets | 348,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other assets | 141,000 | 196,000 | -485,000 | -911,000 | -424,000 | -4,004,000 | 39,000 | -176,000 | 351,000 | -1,561,000 | 3,661,000 | -2,416,000 | -979,000 | -760,000 | -3,047,000 | -371,000 | -1,563,000 | 1,815,000 | 44,000 | 3,853,000 | 496,000 | 244,000 | -884,000 | -173,000 | 292,000 | 62,000 | 105,000 | 14,000 | 17,000 | -27,000 | 34,000 | 6,000 | 0 | 63,000 | -46,953 | 48,000 | 0 | 0 | 0 | 48,000 | -18,536 | 0 | 0 | 18,555 | |||||||||||||||||||||
accounts payable | 6,504,000 | -13,924,000 | -12,975,000 | 25,046,000 | 2,938,000 | 1,059,000 | -2,308,000 | 7,794,000 | -1,128,000 | -1,320,000 | 3,802,000 | 209,000 | -3,189,000 | 2,810,000 | -649,000 | 2,706,000 | -552,000 | -501,000 | -2,698,000 | 9,945,000 | -2,451,000 | 4,628,000 | -757,000 | -2,543,000 | -2,120,000 | 1,853,000 | -2,378,000 | 1,623,000 | 1,551,000 | 138,000 | -701,000 | 309,000 | -855,120 | 522,000 | -131,000 | 537,000 | -412,000 | -747,000 | 1,242,654 | -51,061 | 1,133,510 | 1,874,235 | 277,535 | 178,423 | 17,363 | ||||||||||||||||||||
accrued compensation | 4,421,000 | -1,047,000 | 670,000 | 2,490,000 | 3,661,000 | 1,552,000 | -2,061,000 | 751,000 | 991,000 | 678,000 | -1,571,000 | 551,000 | -460,000 | -924,000 | -3,267,000 | -4,525,000 | -6,902,000 | 16,611,000 | -7,373,000 | 12,953,000 | 1,792,000 | 2,853,000 | -5,802,000 | -2,019,000 | -3,978,000 | 317,000 | 998,000 | 144,000 | -1,844,712 | 449,000 | 1,175,000 | 221,000 | -1,021,000 | -73,000 | 992,000 | 299,000 | -2,012,082 | 885,589 | 390,559 | 736,090 | 787,679 | 231,007 | 532,745 | 470,205 | 135,882 | 377,212 | |||||||||||||||||||
other accrued liabilities | 9,963,000 | 5,422,000 | -7,913,000 | -8,307,000 | 10,414,000 | 7,620,000 | 5,023,000 | -12,414,000 | 5,299,000 | -3,633,000 | 3,487,000 | 7,905,000 | 5,997,000 | -2,421,000 | 5,253,000 | -88,000 | -712,000 | -6,277,000 | 931,000 | 12,567,000 | 6,002,000 | -3,551,000 | 5,447,000 | 775,000 | 38,000 | 29,000 | 438,000 | 2,896,000 | -244,000 | 439,000 | 810,000 | -1,128,653 | 281,000 | 568,000 | 281,000 | ||||||||||||||||||||||||||||||
deferred revenue | 19,298,000 | -2,893,000 | -2,712,000 | -3,600,000 | -5,436,000 | -10,864,000 | -21,957,000 | -13,937,000 | -3,267,000 | -765,000 | -72,000 | -20,417,000 | 3,911,000 | -895,000 | 78,000 | -18,420,000 | -79,000 | -79,000 | 65,208,000 | 534,000 | 3,679,000 | -11,875,000 | 464,000 | 813,000 | 58,000 | 751,000 | 2,650,000 | 781,000 | 149,000 | -2,002,000 | -1,035,000 | 179,000 | 75,000 | -187,878 | -651,558 | 10,818,141 | 569,672 | ||||||||||||||||||||||||||||
operating lease liability | -556,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net cash from operating activities | 2,770,000 | -66,741,000 | -73,719,000 | -60,199,000 | -64,210,000 | -63,991,000 | -41,402,000 | -45,874,000 | -35,042,000 | -43,879,000 | -44,621,000 | 8,535,000 | -30,647,000 | -28,193,000 | -28,315,000 | -35,000,000 | -35,326,000 | -49,955,000 | -32,959,000 | -47,844,000 | -4,558,000 | -7,207,000 | -2,431,000 | -1,180,000 | -3,463,000 | 857,124 | 1,335,212 | -5,845,971 | 6,485,326 | ||||||||||||||||||||||||||||||||||||
cash flows from investing activities: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchases of property and equipment | -369,000 | -125,000 | -47,000 | -893,000 | -102,000 | -771,000 | -23,000 | -21,000 | -83,000 | -407,000 | -228,000 | -2,127,000 | -2,093,000 | -1,099,000 | -1,028,000 | -437,000 | -1,182,000 | ||||||||||||||||||||||||||||||||||||||||||||||||
net cash from investing activities | -1,354,000 | -78,000 | -209,000 | -248,000 | -602,000 | -207,000 | -307,000 | -369,000 | -125,000 | -47,000 | -893,000 | -102,000 | -771,000 | -23,000 | 1,405,000 | 2,229,000 | -407,000 | -228,000 | -2,127,000 | -2,093,000 | -1,099,000 | -1,028,000 | -437,000 | -1,182,000 | -486,000 | 949,000 | 2,118,000 | -13,673,000 | 21,343,000 | -12,373,577 | 4,351,000 | 2,047,000 | 5,995,000 | -1,025,000 | 5,350,000 | 2,292,000 | 1,855,574 | 9,055,073 | -312,566 | 7,366,010 | 610,764 | ||||||||||||||||||||||||
cash flows from financing activities: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of common stock under stock plans | 32,166,000 | 14,906,000 | 39,000 | 425,000 | 449,000 | 411,000 | 620,000 | 1,737,000 | 368,000 | 378,000 | 1,286,000 | 678,000 | 129,000 | 424,000 | 240,000 | 2,062,000 | 73,000 | 670,000 | 68,000 | ||||||||||||||||||||||||||||||||||||||||||||||
proceeds from term loan, net of 3,182 of issuance costs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from common stock issuance, net of 526 of transaction costs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net cash from financing activities | 32,132,000 | 437,557,000 | 39,000 | 26,074,000 | 449,000 | 411,000 | 620,000 | 279,232,000 | 41,390,000 | 344,000 | 34,778,000 | 97,206,000 | 129,000 | 423,000 | 97,984,000 | 2,062,000 | 73,000 | 670,000 | 68,000 | 163,100,000 | 2,259,000 | 96,790,000 | 188,000 | 329,000 | 4,462,000 | 144,000 | 3,030,000 | 4,025,000 | 1,367,000 | 148,000 | 94,694,000 | 716,000 | 352,000 | 120,000 | 575,000 | 1,624,000 | 509,000 | 43,000 | 804,000 | 171,000 | -1,634,850 | 1,380,000 | 231,000 | 26,000 | 66,000 | 818,000 | 25,000 | 241,000 | -479,628 | 389,828 | 85,887 | 4,442 | 121,894 | 96,692 | 2,025 | 104,199 | 334,543 | 5,255,659 | |||||||
net change in cash and cash equivalents | 33,548,000 | 370,738,000 | -73,889,000 | -34,373,000 | -64,363,000 | -63,787,000 | -41,089,000 | 232,989,000 | 6,223,000 | -43,582,000 | -10,736,000 | 105,639,000 | -31,289,000 | -27,793,000 | 71,074,000 | -28,266,000 | -35,334,000 | -30,571,000 | 8,144,000 | -41,853,000 | 126,675,000 | -48,724,000 | -33,396,000 | -49,026,000 | -4,918,000 | -22,593,000 | 72,676,000 | -13,910,000 | 15,670,000 | -2,509,208 | 2,146,000 | -1,094,000 | 1,463,000 | 763,000 | -2,638,000 | 4,195,000 | -930,000 | 771,343 | -16,209 | 173,917 | 1,876,964 | ||||||||||||||||||||||||
cash and cash equivalents, beginning of period | 0 | 0 | 275,138,000 | 0 | 0 | 0 | 478,750,000 | 0 | 0 | 0 | 293,856,000 | 0 | 0 | 0 | 176,225,000 | 0 | 0 | 0 | 262,252,000 | 0 | 0 | 267,107,000 | 159,964,000 | 245,026,000 | 0 | 10,605,000 | |||||||||||||||||||||||||||||||||||||||
cash and cash equivalents, end of period | 33,548,000 | 370,738,000 | 201,249,000 | -34,373,000 | -64,363,000 | -63,787,000 | 437,661,000 | 232,989,000 | 6,223,000 | -43,582,000 | 283,120,000 | 105,639,000 | -31,289,000 | -27,793,000 | 247,299,000 | -28,266,000 | -35,334,000 | -30,571,000 | 270,396,000 | -41,853,000 | 126,675,000 | 218,383,000 | 126,568,000 | 196,000,000 | |||||||||||||||||||||||||||||||||||||||||
supplemental cash flow information: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash paid during the year for interest | 2,539,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash paid during the year for taxes | 1,284,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from common stock issuance, net of 493 of transaction costs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
non-cash interest expense on liability related to sale of future royalties and convertible senior notes | 3,432,000 | 2,546,000 | 2,611,000 | 3,046,000 | 3,575,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
gain on sale/disposal of fixed assets and impairment charges | -855,000 | 140,000 | 1,960,000 | 444,000 | 180,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from sale of equipment | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
payments upon settlement of convertible senior notes | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from warrant issuance, net of 391 of transaction costs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from common stock issuance, net of 373 and 701 of transaction costs, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from warrant issuance, net of 181 of transaction costs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from common stock issuance, net of 143 of transaction costs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from common stock issuance, net of 106 of transaction costs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from common stock issuance, net of 70 of transaction costs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(gain) loss on sale/disposal of fixed assets and impairment charges | 0 | 0 | 18,000 | -709,000 | 0 | 0 | -30,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
operating lease right-of-use asset impairment | 0 | 135,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from common stock issuance, net of 143 and 230 of transaction costs, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from common stock issuance, net of 106 and 230 of transaction costs, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from common stock issuance, net of 70 and 229 of transaction costs, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred rent | -3,000 | -74,000 | 15,000 | 25,000 | 63,000 | 64,000 | 41,000 | 27,000 | 29,000 | 92,000 | 14,000 | 8,000 | 8,000 | 19,000 | 14,000 | 692,000 | 924,000 | 5,000 | -46,931 | 15,000 | 15,000 | 17,000 | 23,000 | 22,000 | 7,000 | 1,000 | -3,602 | 1,203 | 1,202 | 1,202 | |||||||||||||||||||||||||||||||||||
proceeds from common stock issuance, net of 701 and 395 of transaction costs, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
unbilled revenue/reimbursement | 0 | 1,748,000 | -752,000 | 2,008,000 | -535,000 | 1,508,000 | -3,365,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from common stock issuance, net of 230 of transaction costs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from common stock issuance, net of 229 of transaction costs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
non-cash debt conversion expense | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net cash (used) provided for operating activities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from common stock issuance, net of 395 and 222 of transaction costs, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
fees for debt conversion | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from common stock issuance, net of 395 of transaction costs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from common stock issuance, net of 367 of transaction costs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net cash provided (used) for operating activities | 10,203,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
assets | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
unbilled revenue | -1,442,000 | 1,000 | 2,316,000 | -258,000 | 4,727,000 | -51,000 | 545,000 | 75,000 | 142,000 | 390,000 | 121,000 | 130,000 | 1,611,000 | 317,000 | 10,000 | -632,000 | 1,098,000 | -860,000 | 983,441 | 117,497 | |||||||||||||||||||||||||||||||||||||||||||||
non-cash royalty receivable | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total current assets | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
property and equipment, net of accumulated depreciation | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total assets | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liabilities and shareholders’ equity | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of deferred lease incentive | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of liability related to the sale of future royalties, net of deferred financing costs of 753 and 772, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of deferred revenue | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total current liabilities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred lease incentive, net of current portion | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred revenue, net of current portion | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible 4.5% senior notes, net of deferred financing costs of 36 and 50, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liability related to the sale of future royalties, net of current portion and deferred financing costs of 1,536 and 2,373, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other long-term liabilities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total liabilities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
commitments and contingencies | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
shareholders’ deficit: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, .01 par value; authorized 5,000 shares; no shares issued and outstanding | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
common stock, 0.01 par value; authorized 200,000 shares; issued and outstanding 149,400 and 132,526 shares as of december 31, 2018 and december 31, 2017, respectively | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
additional paid-in capital | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accumulated deficit | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total shareholders’ equity | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total liabilities and shareholders’ equity | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net cash (used) provided by operating activities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from stock options exercised | 124,000 | 560,000 | 2,259,000 | 182,000 | 188,000 | 329,000 | 4,462,000 | 144,000 | 3,030,000 | 4,025,000 | 1,367,000 | 163,000 | 688,000 | 716,000 | 352,000 | 120,000 | 575,000 | 1,624,000 | 509,000 | 43,000 | 804,000 | 171,000 | -1,634,850 | 1,380,000 | 231,000 | 26,000 | 66,000 | 818,000 | 25,000 | 241,000 | -479,628 | 389,828 | 85,887 | 4,442 | 121,894 | 96,692 | 2,025 | 0 | 66,793 | 277,242 | 222,267 | ||||||||||||||||||||||||
net cash provided (used) for financing activities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred revenue, net of non-cash upfront license payment | -12,811,000 | -74,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
gain on sale/disposal of fixed assets | 0 | 20,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
impairment charge related to restructuring | 970,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from landlord for tenant improvements | 41,000 | 393,000 | 750,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(gain) loss on sale/disposal of fixed assets | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
gain on forward contracts | 44,000 | 103,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
non-cash licensing fee | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
restricted cash | 700,000 | 0 | 255,000 | 0 | 0 | 47,000 | 48,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
payments from settlement of forward contracts | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from sale of future royalties, net of 5,865 of transaction costs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of convertible 4.5% notes, net of 3,392 of transaction costs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
changes in operating assets and liabilities: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
payments for transaction costs related to sale of future royalties | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents, beginning balance | 0 | 0 | 278,109,000 | 142,261,000 | 0 | 194,960,000 | 0 | 0 | 160,938,000 | 191,206,000 | 0 | 109,156,000 | 0 | 0 | 69,639,000 | 31,619,000 | -4,808,187 | 0 | 0 | 4,813,000 | 0 | 0 | 0 | 3,423,000 | -6,761,287 | 0 | 0 | 6,768,055 | 0 | 0 | 10,132,389 | 0 | 0 | 16,233,408 | 0 | 0 | 14,822,519 | ||||||||||||||||||||||||||||
cash and cash equivalents, ending balance | -29,370,000 | -35,560,000 | 247,843,000 | 121,798,000 | 3,250,000 | 174,838,000 | -4,918,000 | -22,593,000 | 233,614,000 | 179,765,000 | 33,544,000 | 94,942,000 | -10,188,000 | -7,421,000 | 58,641,000 | 31,209,000 | -7,317,395 | 2,146,000 | -1,094,000 | 6,276,000 | 763,000 | -2,638,000 | 4,195,000 | 2,493,000 | -7,693,683 | 771,343 | -16,209 | 6,941,972 | 10,319,328 | 4,083,146 | 5,450,276 | -1,554,050 | -6,254,567 | 15,239,778 | 6,237,561 | -2,854,608 | 16,699,483 | ||||||||||||||||||||||||||||
proceeds from common stock issuance | 0 | -15,000 | 94,006,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(gain) loss on forward contracts | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
amortization of deferred lease incentive obligation | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds (payments) from settlement of forward contracts | 22,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss on forward contracts | 2,000 | 65,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
amortization of deferred lease incentive | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
gain on sale of marketable securities | 525 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from maturities or sales of marketable securities | 0 | 1,201,000 | 116,000 | 119,000 | 509,000 | 2,830,000 | 4,562,000 | 21,744,000 | -213,589,310 | 113,727,000 | 44,303,000 | 55,857,000 | 93,803,000 | 88,857,000 | 231,279,000 | 139,457,000 | -782,333,777 | 315,040,695 | 253,214,204 | 215,146,639 | 70,017,855 | 72,018,496 | 91,428,415 | ||||||||||||||||||||||||||||||||||||||||||
(payments) proceeds from settlement of forward contracts | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss on sale/disposal of fixed assets | 0 | 2,000 | 35,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from settlement of forward contracts | 96,000 | 211,000 | 69,000 | -6,968 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss on sale of marketable securities | 33,000 | 1,000 | -5,000 | 7,000 | 22,000 | 4,000 | 55,074 | 1,005 | 3,106 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other-than-temporary impairment of marketable securities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
gain on sale of fixed assets | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other-than-temporary impairment of investments | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
impairment of investments | 136,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
amortization of lease incentive obligation | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
gain on disposal of fixed assets | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stock–based compensation | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
reclassification of cash equivalent balance to marketable securities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchases of marketable securities | -49,369,000 | -85,417,000 | -89,425,000 | -225,241,000 | -136,669,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from sale of fixed assets | 0 | 0 | 1,000 | 2,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents, ending of period | -13,910,000 | 26,275,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
supplemental disclosure: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash paid for income taxes | 4,000 | 18,000 | -31,966 | 12,000 | 5,000 | 15,000 | 0 | 7,000 | 0 | 10,000 | -15,524 | -13,691 | 11,250 | 18,000 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||
loss on disposal of fixed assets | 11,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stock—based compensation | 531,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(gain) loss on disposal of fixed assets | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stock-based compensation | 611,000 | 614,000 | 647,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
capital expenditures | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -369,000 | -125,000 | -47,000 | -893,000 | -102,000 | -771,000 | -23,000 | -21,000 | -407,000 | -1,099,000 | -1,028,000 | -437,000 | -1,182,000 | -493,000 | -482,000 | -457,000 | -689,000 | -498,000 | 0 | 0 | 0 | 0 | ||||||||||||||||||||||||||||||||||||
free cash flows | 2,770,000 | -66,741,000 | -73,719,000 | -60,199,000 | -64,210,000 | -63,991,000 | -41,402,000 | -46,243,000 | -35,167,000 | -43,926,000 | -45,514,000 | 8,433,000 | -31,418,000 | -28,216,000 | -28,336,000 | -35,407,000 | -36,425,000 | -50,983,000 | -33,396,000 | -49,026,000 | -5,051,000 | -7,689,000 | -2,888,000 | -1,869,000 | -3,961,000 | 857,124 | 1,335,212 | -5,845,971 | 6,485,326 | ||||||||||||||||||||||||||||||||||||
gain on derivative contracts | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
inventory write-down | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other current accrued liabilities | 635,000 | 564,000 | 329,000 | 274,000 | 250,061 | 847,754 | 1,552,066 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net cash from investing activity | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
inventory reserve | -11,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stock compensation | 540,000 | 706,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
repurchases of common stock | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
compensation for stock options, stock and stock units | -49,388 | 176,721 | 2,925 | 135,193 | 21,248 | 21,463 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deposit on construction in progress | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
non cash activities: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
repurchases of common stock included in other accrued liabilities | -219,216 | 576,602 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
capital expenditures included in accounts payable | -376,739 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(gain) loss on sale of marketable securities | 21,873 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
realized gains on sale of marketable securities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
gain on sale of property and equipment | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from sales and maturities of marketable securities | 94,638,529 | 71,096,017 | 92,059,231 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from sale of property and equipment | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from warrants exercised | 40,226 | 60,011 | 5,035,999 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
principal payments on capital lease obligations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
supplemental disclosures: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
non-cash activities: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
repurchases of common stock included in other current accrued liabilities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
compensation for stock and stock units | 11,995 | 11,994 | 11,968 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accrued financing fees | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
payment of deposit on construction in progress | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash paid for taxes | 29,000 | 317 | 0 | 66,912 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cumulative effect of change in accounting principle | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
realized gain on sale of marketable securities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(gain)/loss on sale of property and equipment | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
due from related parties | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
sales and maturities (purchases) of marketable securities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
earned and unbilled revenue | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss on sale of property and equipment | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
due from collaborative partners | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
sales or maturities (purchases) of marketable securities | 1,162,816 |

