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Unit: USD	2025-09-28	2025-06-29	2025-03-30	2024-12-29	2024-09-29	2024-06-30	2024-03-31	2023-12-31	2023-10-01	2023-07-02	2023-04-02	2023-01-01	2022-10-02	2022-07-03	2022-04-03	2022-01-02	2021-10-03	2021-07-04	2021-04-04	2021-01-03	2020-09-27	2020-06-28	2020-03-29	2019-12-29	2019-09-29	2019-06-30	2019-03-31	2018-12-30	2018-09-30	2018-07-01	2018-04-01	2017-12-31	2017-10-01	2017-07-02	2017-04-02	2017-01-01	2016-10-02	2016-07-03	2016-04-03	2016-01-03	2015-09-27	2015-06-28	2015-03-29	2014-12-28	2014-09-28	2014-06-29	2014-03-30	2013-12-29	2013-09-29	2013-06-30	2013-03-31	2012-12-30	2012-09-30	2012-07-01	2012-04-01

cash flows from operating activities:
net income	150,000,000	235,000,000	131,000,000	187,000,000	704,000,000	-1,988,000,000	-126,000,000	-175,000,000	-755,000,000	-234,000,000	3,000,000	-139,000,000	-3,816,000,000	-535,000,000	86,000,000		317,000,000	186,000,000	147,000,000																							102,247,000	136,658,000	153,280,000	93,489,000	46,605,000	59,977,000	80,661,000	31,357,000	35,877,000	-22,587,000	71,903,000	29,748,000	23,401,000	26,202,000
adjustments to reconcile net income to net cash from operating activities:
depreciation expense	50,000,000	51,000,000	52,000,000	54,000,000	54,000,000	57,000,000	59,000,000	60,000,000	59,000,000	59,000,000	57,000,000	57,000,000	56,000,000	52,000,000	50,000,000	48,000,000	46,000,000	41,000,000	41,000,000	42,000,000	39,000,000	38,000,000	37,000,000	38,000,000	37,000,000	39,000,000	37,000,000	40,000,000	35,000,000	35,000,000	30,000,000	29,000,000	29,000,000	26,000,000	26,000,000	24,522,000	23,004,000	21,755,000	20,674,000	19,913,000	18,570,000	17,450,000	16,754,000	17,122,000	14,798,000	15,392,000	14,593,000	13,729,000	13,363,000	11,959,000	11,759,000	12,685,000	12,087,000	11,518,000	11,959,000
amortization of intangible assets	17,000,000	17,000,000	17,000,000	17,000,000	16,000,000	48,000,000	49,000,000	49,000,000	49,000,000	49,000,000	50,000,000	49,000,000	47,000,000	42,000,000	41,000,000	41,000,000	19,000,000	8,000,000	7,000,000	8,000,000	8,000,000	8,000,000	7,000,000	7,000,000	10,000,000	10,000,000	10,000,000	10,000,000	10,000,000	10,000,000	9,000,000	10,000,000	12,000,000	12,000,000	12,000,000	12,909,000	12,908,000	12,598,000	12,545,000	12,848,000	14,286,000	13,250,000	13,348,000	12,830,000	11,891,000	12,134,000	13,814,000	13,438,000	13,515,000	11,390,000	8,772,000
share-based compensation expense	70,000,000	69,000,000	73,000,000	79,000,000	83,000,000	112,000,000	96,000,000	94,000,000	87,000,000	106,000,000	93,000,000	100,000,000	83,000,000	91,000,000	92,000,000	98,000,000	509,000,000	80,000,000	67,000,000	78,000,000	61,000,000	16,000,000	39,000,000	49,000,000	46,000,000	48,000,000	51,000,000	47,000,000	48,000,000	50,000,000	48,000,000	41,000,000	34,000,000	39,000,000	50,000,000	27,220,000	34,583,000	31,970,000	35,292,000	35,489,000	32,229,000	32,957,000	31,918,000	38,462,000	44,669,000	35,996,000	33,424,000	29,746,000	27,409,000	24,452,000	24,219,000	24,176,000	23,072,000	24,047,000	23,029,000
deferred income taxes	41,000,000	25,000,000	16,000,000	49,000,000	19,000,000	-156,000,000	-24,000,000	9,000,000	-78,000,000	53,000,000	-17,000,000	17,000,000	-6,000,000	-13,000,000	-21,000,000	5,000,000	75,000,000	-77,000,000	-79,000,000	67,000,000	3,000,000	76,000,000	-29,000,000	24,000,000	-19,000,000	17,000,000	-11,000,000	14,000,000	-10,000,000	-11,000,000	-11,000,000		-13,000,000	-20,000,000	86,000,000					-3,175,000	3,098,000	27,129,000	53,452,000	69,418,000	-1,084,000	-2,431,000	33,943,000	21,980,000	-29,810,000	7,871,000	-36,704,000	14,741,000	-8,687,000	-22,429,000	-5,323,000
net (gains) losses on strategic investments	-4,000,000						-5,000,000
change in fair value of contingent consideration liabilities	3,000,000	-21,000,000	-11,000,000	-11,000,000	-49,000,000	-271,000,000	16,000,000	58,000,000	-110,000,000	29,000,000	-1,000,000	25,000,000	-219,000,000
goodwill and intangible impairment	0
property and equipment and right-of-use asset impairment				14,000,000	0	0	32,000,000	44,000,000
gain on helix contingent value right					-4,000,000	-8,000,000	-3,000,000				-3,000,000	-1,000,000	5,000,000	8,000,000	-5,000,000
other	9,000,000	11,000,000	-2,000,000	3,000,000	22,000,000	-20,000,000	9,000,000	1,000,000	-5,000,000	7,000,000	7,000,000	10,000,000	4,000,000	4,000,000	-1,000,000	52,000,000	-6,000,000	2,000,000	-19,000,000	-19,000,000	-2,000,000	-10,000,000	-2,000,000	9,000,000	-5,000,000	0	-5,000,000			0	-6,000,000	3,000,000	3,000,000	-3,000,000	-2,000,000	9,569,000	1,759,000	4,486,000	-1,055,000	4,060,000	4,296,000	636,000	556,000	5,530,000	4,121,000	331,000	-636,000	2,002,000	389,000	-1,965,000	4,107,000
changes in operating assets and liabilities:
accounts receivable	-36,000,000	3,000,000	46,000,000	-45,000,000	-52,000,000	-18,000,000	90,000,000	-9,000,000	47,000,000	-79,000,000	1,000,000	-25,000,000	12,000,000	-30,000,000	31,000,000	-39,000,000	-64,000,000	-22,000,000	-39,000,000	-19,000,000	-82,000,000	91,000,000	99,000,000	-29,000,000	-75,000,000	-10,000,000	56,000,000	-81,000,000	-36,000,000	1,000,000	11,000,000	-27,000,000	-13,000,000	-2,000,000	16,000,000	-1,760,000	-8,491,000	26,120,000	-12,630,000	25,396,000	-46,120,000	-15,715,000	-59,474,000	-12,648,000	-20,544,000	34,967,000	-52,156,000	-3,424,000	-24,458,000	5,825,000	6,129,000	2,604,000	-23,832,000	15,945,000	-29,158,000
inventory	-15,000,000	-38,000,000	10,000,000	28,000,000	-13,000,000	0	4,000,000	27,000,000	2,000,000	-31,000,000	-18,000,000	-8,000,000	-41,000,000	-52,000,000	-34,000,000	-31,000,000	-18,000,000	-17,000,000	8,000,000	44,000,000	19,000,000	-51,000,000	-24,000,000	58,000,000	3,000,000	-10,000,000	-26,000,000	-13,000,000	-12,000,000	-11,000,000	-17,000,000	-6,000,000	-18,000,000	-10,000,000	1,000,000	12,071,000	-1,171,000	-23,437,000	-17,149,000	-36,947,000	-11,072,000	-18,482,000	-14,044,000	8,151,000	-21,506,000	-13,196,000	-9,991,000	6,615,000	7,961,000	-93,000	-8,266,000	-10,247,000	-8,650,000	-4,969,000	159,000
prepaid expenses and other current assets	-12,000,000	5,000,000	6,000,000	-3,000,000	5,000,000	7,000,000	-23,000,000	14,000,000	3,000,000	11,000,000	-17,000,000	6,000,000	6,000,000	-7,000,000	11,000,000	-30,000,000	-40,000,000	-1,000,000	7,000,000	-5,000,000	-18,000,000	17,000,000	-14,000,000	0	-3,000,000	-17,000,000	6,000,000	-2,000,000	6,000,000	3,000,000	-2,000,000	-6,000,000	9,000,000	3,000,000	2,000,000	-4,776,000	-1,673,000	7,816,000	-2,571,000	-5,894,000	-3,600,000	-225,000	-1,157,000	26,771,000	-18,690,000	-1,587,000	125,000	3,173,000	-740,000	-2,186,000	1,536,000	-1,660,000	-3,253,000	620,000	1,231,000
operating lease right-of-use assets and liabilities	-8,000,000	-9,000,000	-8,000,000	-11,000,000	-7,000,000	-7,000,000	-7,000,000	-3,000,000	-3,000,000	-5,000,000	-5,000,000	2,000,000	-3,000,000	-4,000,000	-3,000,000	-4,000,000	-4,000,000	-2,000,000	-3,000,000	-2,000,000	-2,000,000	-6,000,000	-1,000,000	-2,000,000	0	-2,000,000	-1,000,000
other assets	-10,000,000	-2,000,000	-1,000,000	-1,000,000	-5,000,000	-3,000,000	-6,000,000	-1,000,000	2,000,000	2,000,000	2,000,000	2,000,000	4,000,000	7,000,000	6,000,000	8,000,000	-28,000,000	-3,000,000	-4,000,000	-8,000,000	-2,000,000	-12,000,000	-11,000,000	-1,000,000	-18,000,000	-3,000,000	-8,000,000	0	-4,000,000	-4,000,000	-1,000,000	-2,000,000	0	-2,000,000	-1,000,000	-822,000	-238,000	-3,418,000	-2,404,000	-990,000	2,918,000	-816,000	-2,530,000	-30,994,000	11,285,000	-7,575,000	-8,972,000	-12,930,000	-165,000	-1,174,000	-2,088,000	-186,000	-730,000	139,000	-2,126,000
accounts payable	13,000,000	-11,000,000	-15,000,000	31,000,000	-5,000,000	7,000,000	-37,000,000	6,000,000	-6,000,000	2,000,000	-46,000,000	13,000,000	1,000,000	-13,000,000	-39,000,000	88,000,000	-40,000,000	20,000,000	-8,000,000	42,000,000	11,000,000	3,000,000	-16,000,000	11,000,000	-3,000,000	4,000,000	-47,000,000	32,000,000	12,000,000	-1,000,000	2,000,000	-2,000,000			-3,000,000	5,338,000	-14,956,000	4,592,000	3,057,000	-3,236,000	18,814,000	1,851,000	28,867,000	-16,854,000	864,000	3,824,000	10,060,000	13,265,000	-8,878,000	-10,457,000	8,459,000	-3,322,000	5,400,000	2,775,000	10,259,000
accrued liabilities	22,000,000	-35,000,000	-56,000,000	-34,000,000	-489,000,000	136,000,000	-53,000,000	40,000,000	-54,000,000	152,000,000	-123,000,000	-7,000,000	-82,000,000	515,000,000	-45,000,000	20,000,000	-81,000,000	57,000,000	105,000,000	61,000,000	-27,000,000	62,000,000	-103,000,000	37,000,000	6,000,000	-17,000,000	-70,000,000	58,000,000	28,000,000	35,000,000	-18,000,000	25,000,000	15,000,000	-11,000,000	52,000,000	33,075,000	-26,052,000	-1,482,000	-29,791,000	70,907,000	33,321,000	26,607,000	-51,044,000	43,304,000	31,739,000	32,006,000	-23,147,000	26,618,000	31,306,000	-4,107,000	-15,267,000	-2,943,000	1,036,000	12,072,000	14,223,000
other long-term liabilities	-10,000,000	12,000,000	14,000,000	37,000,000	25,000,000	-40,000,000	6,000,000	4,000,000	10,000,000	-26,000,000	11,000,000	3,000,000	-19,000,000	-11,000,000	8,000,000	3,000,000	14,000,000	0	-4,000,000	-9,000,000	6,000,000	6,000,000	24,000,000	-19,000,000	-2,000,000	5,000,000	-17,000,000	0	11,000,000	-20,000,000	5,000,000	137,000,000	4,000,000	15,000,000	4,000,000	5,788,000	2,363,000	3,573,000	4,013,000	10,443,000	-6,765,000	24,000	1,521,000	-1,947,000	1,560,000	1,163,000	1,085,000	1,773,000	335,000	334,000	1,374,000	7,747,000	-5,707,000	187,000	4,413,000
net cash from operating activities	284,000,000	234,000,000	240,000,000	364,000,000	316,000,000	80,000,000	77,000,000	224,000,000	139,000,000	105,000,000	10,000,000	147,000,000	-52,000,000	125,000,000	172,000,000	282,000,000	-272,000,000	253,000,000	282,000,000	406,000,000	153,000,000	240,000,000	281,000,000	443,000,000	267,000,000	143,000,000	198,000,000	300,000,000	292,000,000	295,000,000	255,000,000	294,000,000	235,000,000	178,000,000	168,000,000	280,153,000	150,300,000	217,047,000	39,738,000	240,378,000	180,994,000	171,445,000	66,779,000	140,549,000	145,605,000	178,030,000	37,087,000	126,839,000	83,136,000	88,606,000	87,840,000	78,876,000	51,228,000	96,329,000	65,440,000
capex	0	-30,000,000	-32,000,000	0	-32,000,000	-31,000,000	-36,000,000	-51,000,000	-45,000,000	-47,000,000	-52,000,000	-88,000,000	-66,000,000	-71,000,000	-61,000,000	-70,000,000	-52,000,000	-44,000,000	-42,000,000	-62,000,000	-48,000,000	-39,000,000	-40,000,000	-57,000,000	-49,000,000	-47,000,000	-56,000,000	-65,000,000	-64,000,000	-77,000,000	-90,000,000	-76,000,000	-82,000,000	-69,000,000	-83,000,000	-81,538,000	-57,122,000	-67,813,000	-53,418,000	-35,486,000	-29,459,000	-41,351,000	-36,551,000	-34,832,000	-28,828,000	-23,324,000	-19,012,000	-27,310,000	-18,930,000	-11,534,000	-21,441,000	-17,101,000	-17,650,000	-20,946,000	-13,084,000
free cash flows	284,000,000	204,000,000	208,000,000	364,000,000	284,000,000	49,000,000	41,000,000	173,000,000	94,000,000	58,000,000	-42,000,000	59,000,000	-118,000,000	54,000,000	111,000,000	212,000,000	-324,000,000	209,000,000	240,000,000	344,000,000	105,000,000	201,000,000	241,000,000	386,000,000	218,000,000	96,000,000	142,000,000	235,000,000	228,000,000	218,000,000	165,000,000	218,000,000	153,000,000	109,000,000	85,000,000	198,615,000	93,178,000	149,234,000	-13,680,000	204,892,000	151,535,000	130,094,000	30,228,000	105,717,000	116,777,000	154,706,000	18,075,000	99,529,000	64,206,000	77,072,000	66,399,000	61,775,000	33,578,000	75,383,000	52,356,000
cash flows from investing activities:
net purchases of property and equipment
net purchases of strategic investments				-19,000,000																-12,000,000	-5,000,000			-5,000,000	-2,000,000	-10,000,000	-3,000,000	-3,000,000	-3,000,000	-6,000,000	-3,000,000	-4,000,000	0	-18,000,000	-7,000,000	-4,767,000
cash paid for acquisitions and intangible assets, net of cash required
cash received for helix contingent value right				0
net cash from investing activities	-51,000,000	-49,000,000	-63,000,000	-48,000,000	-41,000,000	-41,000,000	-48,000,000	-85,000,000	-53,000,000	-37,000,000	-56,000,000	-102,000,000	-250,000,000	-165,000,000	-74,000,000	0	-2,448,000,000	3,000,000	1,376,000,000	-34,000,000	-65,000,000	-320,000,000	-135,000,000	-104,000,000	-218,000,000	79,000,000	988,000,000	-348,000,000	-940,000,000	-537,000,000	12,000,000	-315,000,000	-97,000,000	35,000,000	163,000,000	-173,292,000	-341,231,000	43,537,000	-43,553,000	229,398,000	-38,927,000	-142,470,000	-154,147,000	-332,783,000	-44,231,000	114,777,000	-144,387,000	-150,810,000	-101,295,000	247,477,000	-65,021,000	18,611,000	-17,105,000	-9,648,000	-141,870,000
cash flows from financing activities:
common stock repurchases	-130,000,000	-370,000,000	-200,000,000	-17,000,000																-281,000,000	-125,000,000	-142,000,000	-188,000,000	-63,000,000	-198,000,000	0	-63,000,000	-98,000,000				-75,000,000	-75,000,000	0	-101,000,000	-136,267,000	-13,075,000			-202,068,000	-37,503,000	0	-34,753,000	-34,752,000	0	-72,414,000	-130,017,000	0	0	-25,009,000	-25,011,000	-30,013,000	-20,010,000
taxes paid related to net share settlement of equity awards	-1,000,000	-1,000,000	-22,000,000	-30,000,000	0	-1,000,000	-1,000,000	-26,000,000	-2,000,000	-3,000,000	-9,000,000	-35,000,000	-2,000,000	-5,000,000	-12,000,000	-59,000,000	-422,000,000	-6,000,000	-24,000,000	-50,000,000	-3,000,000	-3,000,000	-35,000,000	-52,000,000	-4,000,000	-3,000,000	-23,000,000	-56,000,000	-3,000,000	-2,000,000	-13,000,000	-40,000,000	-4,000,000	-2,000,000	-22,000,000	-23,460,000	-3,573,000	-3,272,000	-69,520,000	-32,055,000	-5,175,000	-6,143,000	-83,839,000	-370,000	-259,000	-583,000	-8,826,000
proceeds from issuance of common stock	16,000,000	1,000,000	27,000,000	0	20,000,000	0	36,000,000	0	30,000,000	0	37,000,000	0	30,000,000	0	33,000,000	1,000,000	28,000,000	0	31,000,000	0	27,000,000	2,000,000	32,000,000	0	29,000,000	3,000,000	27,000,000	1,000,000	23,000,000	1,000,000	21,000,000	8,000,000	32,000,000	9,000,000	22,000,000	505,000	20,595,000	3,508,000	23,053,000	6,171,000	23,155,000	12,786,000	29,727,000	11,595,000	30,581,000	22,107,000	32,045,000	14,234,000	39,147,000	30,309,000	10,770,000	15,651,000	10,687,000	3,898,000	24,122,000
payments on contingent consideration liabilities	0			0	0
proceeds from debt, net of issuance costs				0
payments on debt obligations				0
grail cash deconsolidated as a result of spin-off				0	0
net cash from financing activities	-115,000,000	-371,000,000	-195,000,000	-47,000,000	-332,000,000	-226,000,000	35,000,000	-27,000,000	-707,000,000	-3,000,000	-473,000,000	956,000,000	28,000,000	-5,000,000	21,000,000	-129,000,000	-394,000,000	-496,000,000	968,000,000	-331,000,000	-101,000,000	-143,000,000	-191,000,000	-115,000,000	-173,000,000	-549,000,000	-60,000,000	-154,000,000	651,000,000	30,000,000	67,000,000	-109,000,000	-5,000,000	24,000,000	-86,000,000	-163,492,000	34,473,000	-63,345,000	-12,349,000	-253,141,000	-180,897,000	27,810,000	-12,534,000	202,000	55,495,000	-136,521,000	-85,924,000	43,556,000	-75,053,000	5,784,000	-13,006,000	-6,042,000	-8,065,000	-30,264,000	33,616,000
effect of exchange rate changes on cash and cash equivalents	-2,000,000	7,000,000	4,000,000	-11,000,000	6,000,000	-1,000,000	-4,000,000		-5,000,000	-6,000,000	2,000,000	10,000,000	-15,000,000			-1,000,000			-3,000,000			2,000,000	-6,000,000	3,000,000				0	-1,000,000	-4,000,000	1,000,000	1,000,000	2,000,000	1,000,000	1,000,000	-3,550,000	-507,000	-487,000	2,304,000	606,000	-698,000	735,000	-2,715,000	-1,709,000	-2,195,000	422,000	100,000	216,000	1,437,000	-1,338,000	-712,000	-553,000	619,000	-199,000	30,000
net decrease in cash and cash equivalents	116,000,000				-51,000,000																																		-13,860,000			57,520,000	-102,617,000
cash and cash equivalents at beginning of period	0	0	1,127,000,000		0	0	1,048,000,000		0	0	2,011,000,000		0	0	1,232,000,000		0	0	1,810,000,000		0	0	2,042,000,000		0	0	1,144,000,000		0	0	1,225,000,000		0	0	735,000,000		0	0	768,770,000		0	0	636,154,000		0	0	711,637,000		0	0	433,981,000		0	0	302,978,000
cash and cash equivalents at end of period	116,000,000	-179,000,000	1,113,000,000		-51,000,000	-188,000,000	1,108,000,000		-626,000,000	59,000,000	1,494,000,000		-289,000,000	-62,000,000	1,351,000,000		-3,116,000,000	-237,000,000	4,433,000,000		-9,000,000	-221,000,000	1,991,000,000		-128,000,000	-327,000,000	2,270,000,000		2,000,000	-216,000,000	1,560,000,000		135,000,000	238,000,000	981,000,000		-156,965,000	196,752,000	754,910,000		-39,528,000	57,520,000	533,537,000		154,674,000	156,708,000	518,513,000		-91,775,000	340,529,000	443,082,000		26,677,000	56,218,000	260,194,000
supplemental cash flow information:
grail net assets, excluding cash and cash equivalents, deconsolidated as a result of spin-off				0	0
purchases of property and equipment		-30,000,000	-32,000,000		-32,000,000	-31,000,000	-36,000,000	-51,000,000	-45,000,000	-47,000,000	-52,000,000	-88,000,000	-66,000,000	-71,000,000	-61,000,000	-70,000,000	-52,000,000	-44,000,000	-42,000,000	-62,000,000	-48,000,000	-39,000,000	-40,000,000	-57,000,000	-49,000,000	-47,000,000	-56,000,000	-65,000,000	-64,000,000	-77,000,000	-90,000,000	-76,000,000	-82,000,000	-69,000,000	-83,000,000	-81,538,000	-57,122,000	-67,813,000	-53,418,000	-35,486,000	-29,459,000	-41,351,000	-36,551,000	-34,832,000	-28,828,000	-23,324,000	-19,012,000	-27,310,000	-18,930,000	-11,534,000	-21,441,000	-17,101,000	-17,650,000	-20,946,000	-13,084,000
purchases of strategic investments		-19,000,000	-24,000,000			-10,000,000	-12,000,000		-8,000,000	-8,000,000	-3,000,000		-4,000,000	-9,000,000	-13,000,000	-8,000,000	-32,000,000	-9,000,000	-3,000,000																														399,000			-908,000	0	-7,530,000	-7,500,000
cash paid for intangible assets		0	-7,000,000																													0				0				-125,000	0			-29,500,000	-6,095,000	0	-625,000	-8,499,000	-2,000	-2,342,000	-501,000	-899,000
borrowings on delayed draw term loan, net of issuance costs
net gains on strategic investments			-32,000,000
net increase in cash and cash equivalents			-14,000,000				60,000,000			59,000,000	-517,000,000			-62,000,000	119,000,000			-237,000,000	2,623,000,000	49,000,000	-9,000,000	-221,000,000	-51,000,000	227,000,000	-128,000,000	-327,000,000	1,126,000,000	-202,000,000	2,000,000	-216,000,000	335,000,000	-129,000,000	135,000,000	238,000,000	246,000,000	-60,181,000	-156,965,000			217,241,000				-193,741,000	154,674,000	156,708,000	-193,124,000	19,801,000	-91,775,000	340,529,000	9,101,000	90,892,000	26,677,000	56,218,000	-42,784,000
net incomees on strategic investments				-30,000,000	12,000,000				20,000,000	3,000,000	16,000,000			32,000,000	44,000,000
(gain) loss on helix contingent value right								-2,000,000	-5,000,000
goodwill and intangible (ipr&d) impairment				0	0			6,000,000
cash paid for acquisitions and intangible assets, net of cash acquired				0
cash and cash equivalents at beginning of year
cash and cash equivalents at end of year
cash paid for interest
cash paid for income taxes
cash paid for operating lease liabilities																								21,000,000	21,000,000	21,000,000	21,000,000
purchases of property and equipment included in accounts payable and accrued liabilities
sales of strategic investments									0							78,000,000	0	136,000,000	84,000,000
cash paid for intangible asset								0	0	0	-1,000,000	0
debt issuance costs paid for credit facility								0	0	0	-1,000,000
payments on term notes										0	-500,000,000
payments on financing obligations								0																0	0	-549,000,000	-1,000,000	-1,000,000	-1,000,000	0	-2,000,000	-2,000,000	-1,000,000	-5,000,000	-1,000,000	4,625,000	1,050,000	4,103,000	-75,675,000	-28,745,000	-207,543,000	-8,550,000	-114,000	-111,000	-133,000	-93,000	-29,654,000
accretion of debt discount on convertible senior notes																6,000,000	7,000,000
gain on previously held investment in grail																1,000,000
gain on exchange of grail contingent value rights
net incomees (gains) on strategic investments												43,000,000
payment of accreted debt discount								0																0	0
gain on derivative assets related to terminated acquisition
unrealized loss on foreign exchange translation								1,000,000
maturities of available-for-sale securities																0	0	0	331,000,000	166,000,000	109,000,000	111,000,000	107,000,000	125,000,000	58,000,000	173,000,000	1,031,000,000	150,000,000	154,000,000	141,000,000	415,000,000	140,000,000	85,000,000	48,000,000	48,000,000	-8,648,000	35,615,000	36,220,000	76,455,000	104,295,000	94,317,000	53,048,000	42,564,000	32,000,000	25,586,000	48,568,000	44,075,000	165,966,000	11,900,000	44,772,000	66,559,000	37,078,000	28,200,000	78,546,000	21,600,000
purchases of available-for-sale securities																0	0	0	-77,000,000	-1,045,000,000	-210,000,000	-291,000,000	-256,000,000	-250,000,000	-367,000,000	-276,000,000	-117,000,000	-507,000,000	-1,215,000,000	-539,000,000	-598,000,000	-383,000,000	-273,000,000	-25,000,000	-61,000,000	-215,305,000	-376,517,000	-217,665,000	-84,882,000	-83,160,000	-135,437,000	-253,042,000	-325,383,000	-362,552,000	-69,826,000	-105,619,000	-253,255,000	-185,489,000	-21,013,000	-60,019,000	-97,480,000	-123,125,000	-240,112,000	-230,589,000	-331,652,000
sales of available-for-sale securities																0	0	0	1,031,000,000	919,000,000	92,000,000	101,000,000	186,000,000	101,000,000	142,000,000	268,000,000	118,000,000	77,000,000	188,000,000	44,000,000	288,000,000	8,000,000	175,000,000	99,000,000	40,000,000	136,966,000	70,987,000	296,290,000	39,009,000	247,177,000	71,904,000	111,291,000	152,156,000	67,101,000	33,290,000	202,234,000	89,030,000	-99,064,000	18,668,000	281,076,000	322,955,000	66,747,000	306,942,000	170,871,000	188,766,000
net (purchases) sales of strategic investments
cash received for derivative assets related to terminated acquisition
net cash paid for acquisitions												0	0			0	-2,364,000,000			0								0	0							0	0	34,000	-17,875,000	-1,355,000				0				-86,023,000	-92,317,000	-50,000	-345,111,000	0
net proceeds from issuance of debt																0	0	0	988,000,000
see accompanying notes to consolidated financial statements.
impairment of long-lived assets
goodwill impairment												0
(gain) loss on derivative assets related to terminated acquisition																0	0	0	-26,000,000
cash received (paid for) derivative assets related to terminated acquisition																0	0	0	52,000,000
payments on convertible senior notes																0	0	-490,000,000	-27,000,000
change in fair value of contingent consideration liability															-49,000,000
consolidated net income																				257,000,000	179,000,000	47,000,000	173,000,000	239,000,000	234,000,000	293,000,000	224,000,000	197,000,000	188,000,000	200,000,000	197,000,000	57,000,000	153,000,000	120,000,000	348,000,000	107,542,000	116,935,000	116,394,000	87,219,000	102,864,000
payment of accreted debt discount on convertible senior notes
gains on strategic investments
gains on deconsolidations
deconsolidation of helix cash																									0
proceeds from the deconsolidation of grail
losses (gains) on equity securities																	-41,000,000
change in fair value of contingent consideration																																								325,000	1,109,000	2,329,000	-9,887,000	-2,398,000	333,000	-1,531,000	-1,760,000	-7,753,000	-5,769,000	-5,726,000	464,000	262,000	-1,104,000	1,080,000	1,737,000
accretion of debt discount																			10,000,000	11,000,000	10,000,000	9,000,000	10,000,000	10,000,000	9,000,000	13,000,000	14,000,000	15,000,000	10,000,000	8,000,000	8,000,000	7,000,000	8,000,000	8,000,000	7,000,000	7,390,000	7,333,000	7,278,000	7,731,000	8,689,000	9,452,000	10,207,000	10,169,000	10,080,000	9,992,000	9,005,000	8,992,000	9,142,000	9,063,000	9,023,000	9,009,000	8,904,000	8,802,000	8,699,000	8,599,000
losses (gains) on marketable equity securities																			72,000,000
unrealized gains on marketable equity securities																				-142,000,000	-59,000,000	-66,000,000	-3,000,000	4,000,000	47,000,000
gains on deconsolidation																								0	0
loss on derivative assets related to terminated acquisition																				0	9,000,000	12,000,000	95,000,000
cash paid for derivative assets related to terminated acquisition																				0	0	0	-132,000,000
contributions from noncontrolling interest owners																												0	0	31,000,000	61,000,000	0	43,000,000	20,000,000	16,000,000	9,000,000	0	0	80,000,000	0
1. organization and significant accounting policies
net cash paid for acquisition
gain on deconsolidation of grail																											-15,000,000					0	0	0	-453,000,000
loss on continuation advances
impairment of intangible assets																																0	0	0	23,000,000
cash paid for continuation advances
deconsolidation of helix and grail cash
payments on acquisition-related contingent consideration liability
proceeds from deconsolidation of grail																									0	0	15,000,000
assets
property and equipment																									0
operating lease right-of-use assets
deferred tax assets																									0
total assets																									0
liabilities and stockholders’ equity
operating lease liabilities
long-term debt																									0
retained earnings																									0
total liabilities and stockholders’ equity																									0
proceeds from sale of grail securities																																0	0	0	278,000,000
deconsolidation of grail cash																																0	0	0	-52,000,000
proceeds from early exercise of equity awards from a subsidiary																																				707,000	804,000
payments on acquisition related contingent consideration liability																																	0			0	0	0	-29,200,000	-1,400,000								0	0	0	-3,985,000
proceeds from issuance of debt																																0	0			0	2,958,000
deferred income tax expense																																				36,023,000	29,710,000
cost-method investment gain																																								-119,000	-2,900,000	0	-12,582,000
gain on litigation settlement
illumina, inc.consolidated statements of cash flows —
loss on extinguishment of debt																																								325,000	3,504,000			0	0
incremental tax benefit related to share-based compensation																																				18,602,000	-25,714,000	-25,227,000	-58,993,000	-4,956,000	-15,541,000	-29,717,000	-76,445,000	-23,840,000	-25,306,000	-26,805,000	-50,528,000	-29,453,000	-12,381,000	-9,566,000	-5,278,000
repurchase of convertible notes
net (purchases of) sales proceeds from strategic investments																																						-3,529,000	-2,842,000					-5,000,000
deferred income tax (benefit) expense																																							-6,200,000
(gain) impairment related to discontinued product line
change in estimated cease-use loss																																								436,000	-5,226,000	1,480,000	699,000	1,294,000	870,000
accrued legal contingencies																																								4,000,000				-45,717,000	11,483,000	4,817,000	5,847,000		4,299,000	15,791,000	106,922,000
proceeds from issuance of convertible notes																																												0	0
payments on retirement of warrants
net sales proceeds from (purchases of) strategic investments																																									-5,026,000	-12,141,000	13,067,000
repurchases of convertible notes																																													0
contingent compensation expense																																												68,000	68,000	68,000	2,417,000	4,169,000	1,358,000	1,358,000	1,393,000	2,257,000	1,084,000	44,000	2,921,000
cost-method investment related gain																																												0				-55,244,000	0	0	-6,113,000
unsettled short-term investments purchase
impairments																																																0
(purchases of) sales proceeds from strategic investments																																														-7,082,000	-4,600,000
change in facility exit obligation																																																2,856,000
long-term legal contingencies
proceeds from (purchases of) strategic investments
payments on current portion of long-term financing obligations
(payments for) proceeds from warrant settlements
proceeds from sale of strategic investment																																																	0	3,000	9,998,000
payments on long-term financing obligations																																																	-1,581,000
impairment of in-process research and development																																																				0	0
payments on long-term financing obligation																																																			-58,000
amortization of acquired intangible assets																																																				5,411,000	3,740,000	3,195,000	3,195,000
cease-use loss																																																				2,883,000
cost-method investment related (gain) loss
recovery of previously impaired note receivable
sales and maturities of trading securities
payments on current portion of long-term debt
proceeds from the exercise of warrants
incremental tax benefit related to stock options exercised																																																					-1,258,000	-1,711,000	-9,494,000
other non-cash adjustments																																																					1,586,000	3,108,000	2,484,000
unrealized (gain) loss on foreign exchange
cash paid in business combination milestones																																																					0
unrealized gain on foreign exchange																																																						-2,830,000	1,130,000
proceeds from exercises of warrants

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