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Structure Therapeutics Inc.
(NASDAQ:GPCR) 

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Structure Therapeutics Inc., a clinical stage global biopharmaceutical company, develops and delivers novel oral therapeutics to treat a range of chronic diseases with unmet medical needs. Its lead product candidate is GSBR-1290, an oral and biased small molecule agonist of glucagon-like-peptide-1 r...

Founded: 2016
IPO Price: $15 (Feb 03, 2023)
Sector: Healthcare
Industry: Biotechnology
Healthcare
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At a glance:
Bull Thesis:
Bear Thesis:
Main Competitors:
Moat:
Income Statements:
Quarterly
Annual
    Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 
                  
      operating expenses:
    		              
      research and development
    		66,507,000 68,689,000 58,989,000 54,710,000 42,867,000 33,487,000 32,598,000 22,050,000 20,679,000 20,042,000 17,515,000 19,411,000 13,135,000  
      general and administrative
    		22,872,000 17,571,000 14,798,000 15,741,000 13,444,000 13,574,000 13,238,000 11,266,000 11,336,000 10,952,000 8,630,000 6,576,000 6,514,000  
      total operating expenses
    		89,379,000 -23,989,000 73,787,000 70,451,000 56,311,000 47,061,000 45,836,000 33,316,000 32,015,000 30,994,000 26,145,000 25,987,000 19,649,000  
      income from operations
    		-89,379,000 23,989,000 -73,787,000 -70,451,000 -56,311,000 -47,061,000 -45,836,000 -33,316,000 -32,015,000 -30,994,000 -26,145,000 -25,987,000 -19,649,000  
      yoy
    		58.72% -150.97% 60.98% 111.46% 75.89% 51.84% 75.31% 28.20% 62.93%      
      qoq
    		-472.58% -132.51% 4.74% 25.11% 19.66% 2.67% 37.58% 4.06% 3.29% 18.55% 0.61% 32.26%   
      interest and other income
    		13,601,000 9,185,000 8,183,000 8,929,000 9,576,000 10,718,000 11,951,000 7,335,000 6,008,000 6,179,000 2,688,000 2,825,000 1,699,000  
      income before provision for income taxes
    		-75,778,000 33,174,000 -65,604,000 -61,522,000 -46,735,000 -36,343,000 -33,885,000 -25,981,000 -26,007,000 -24,815,000 -23,457,000 -23,162,000 -17,950,000  
      provision for income taxes
    		190,000 170,000 108,000 139,000 98,000 136,000 92,000 53,000 29,000 -312,000 405,000 118,000 25,000  
      net loss attributable to ordinary shareholders
    		-75,968,000 33,004,000 -65,712,000 -61,661,000 -46,833,000 -36,479,000 -33,977,000 -26,034,000 -26,036,000 -24,503,000 -23,862,000 -23,280,000 -17,975,000  
      net income per share
    		-0.35 0.2 -0.37 -0.36 -0.27 -0.22 -0.2 -0.18 -0.19 -0.16 -0.21 -0.2 -0.25  
      weighted-average ordinary shares used in computing net loss per share attributable to ordinary shareholders, basic and diluted
    		217,326 177,596 175,469 172,647 172,051 157,922 171,630 148,239 139,710 110,198 114,948 114,759 71,655  
      other comprehensive loss:
    		              
      unrealized loss on investments
    		-3,249   -453 -99   -397    -537   
      total other comprehensive loss
    		-3,249   -453 -99   -397  -50 80 -537   
      comprehensive loss
    		-79,217 33,233 -65,249 -62,114 -46,932 -38,404 -30,651 -26,431 -26,647 -23,672 -23,782 -23,817 -17,718  
      other comprehensive gain:
    		              
      unrealized gain on investments
    		 229 463   -1,925 3,326  -611 831 80  257  
      total other comprehensive gain
    		 -22.25 463   -1,925 3,326      257  
      total other comprehensive income
    		        -611      
      net income
    		         -24,503,000 -23,862,000 -23,280,000   
      yoy
    		              
      qoq
    		         2.69% 2.50%    
      less: accretion of redeemable convertible preferred shares to their redemption value
    		              
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 
                    
        assets
      		              
        current assets:
      		              
        cash and cash equivalents
      		316,168,000 799,623,000 102,912,000 147,024,000 152,123,000 169,510,000 172,130,000 381,627,000 97,832,000 129,792,000 50,636,000 40,591,000 126,493,000 26,091,000 
        short-term investments
      		1,142,336,000 646,574,000 696,131,000 639,472,000 684,759,000 714,008,000 743,156,000 545,492,000 338,617,000 337,531,000 154,788,000 183,996,000 114,369,000 64,750,000 
        other receivable
      		 100,000,000             
        prepaid expenses and other current assets
      		32,094,000 24,106,000 14,979,000 12,802,000 12,740,000 7,693,000 8,365,000 10,502,000 12,911,000 6,285,000 4,535,000 3,635,000 5,293,000 2,248,000 
        total current assets
      		1,490,598,000 1,570,303,000 814,022,000 799,298,000 849,622,000 891,211,000 923,651,000 937,621,000 449,360,000 473,608,000 209,959,000 228,222,000 246,155,000 93,089,000 
        property and equipment
      		6,365,000 6,653,000 4,675,000 3,459,000 3,518,000 3,478,000 3,735,000 3,315,000 3,120,000 3,228,000 2,408,000 1,078,000 961,000 1,031,000 
        operating right-of-use assets
      		5,606,000 6,245,000 6,863,000 7,484,000 7,313,000 3,535,000 4,009,000 4,267,000 4,698,000 5,136,000 3,653,000 90,000 178,000 262,000 
        other non-current assets
      		5,555,000 717,000 6,599,000 6,202,000 6,096,000 5,106,000 1,822,000 1,826,000 47,000 45,000 350,000 38,000 59,000 3,463,000 
        total assets
      		1,508,124,000 1,583,918,000 832,159,000 816,443,000 866,549,000 903,330,000 933,217,000 947,029,000 457,225,000 482,017,000 216,370,000 229,428,000 247,353,000 97,845,000 
        liabilities and shareholders’ equity
      		              
        current liabilities:
      		              
        accounts payable
      		7,822,000 13,864,000 17,796,000 8,990,000 8,710,000 8,024,000 8,447,000 2,209,000 6,538,000 4,742,000 3,319,000 5,699,000 4,945,000 6,009,000 
        accrued expenses and other current liabilities
      		46,553,000 46,543,000 36,929,000 27,379,000 25,306,000 26,299,000 23,275,000 18,821,000 15,448,000 18,558,000 15,955,000 9,241,000 5,889,000 6,741,000 
        operating lease liabilities, current portion
      		2,609,000 2,878,000 2,802,000 2,664,000 2,471,000 1,698,000 1,712,000 1,629,000 1,600,000 1,440,000 817,000 73,000 168,000 260,000 
        total current liabilities
      		56,984,000 63,285,000 57,527,000 39,033,000 36,487,000 36,021,000 33,434,000 22,659,000 23,586,000 24,740,000 20,091,000 15,013,000 11,002,000 13,010,000 
        operating lease liabilities, net of current portion
      		3,183,000 3,609,000 4,288,000 5,012,000 5,116,000 2,164,000 2,673,000 3,045,000 3,525,000 4,013,000 3,034,000    
        other non-current liabilities
      		863,000 647,000 325,000 317,000 308,000 302,000 309,000 293,000 296,000 298,000 281,000    
        total liabilities
      		61,030,000 67,541,000 62,140,000 44,362,000 41,911,000 38,487,000 36,416,000 25,997,000 27,407,000 29,051,000 23,406,000 15,013,000 11,002,000 13,010,000 
        commitments and contingencies
      		              
        shareholders’ equity:
      		              
        undesignated shares – 0.0001 par value...
      		              
        ordinary shares – 0.0001 par value...
      		21,000 21,000 18,000 17,000 17,000 17,000 17,000 17,000 14,000 14,000 10,000 10,000 11,000 1,000 
        additional paid-in capital
      		1,995,536,000 1,985,602,000 1,272,480,000 1,209,294,000 1,199,737,000 1,193,010,000 1,186,564,000 1,180,144,000 662,502,000 659,003,000 375,332,000 373,001,000 371,120,000 1,921,000 
        accumulated other comprehensive income
      		-2,195,000 1,054,000 825,000 362,000 815,000 914,000 2,839,000 -487,000 -90,000 521,000   147,000  
        accumulated deficit
      		-546,268,000 -470,300,000 -503,304,000 -437,592,000 -375,931,000 -329,098,000 -292,619,000 -258,642,000 -232,608,000 -206,572,000 -182,069,000 -158,207,000 -134,927,000 -116,952,000 
        total shareholders’ equity
      		1,447,094,000 1,516,377,000 770,019,000 772,081,000 824,638,000 864,843,000 896,801,000 921,032,000 429,818,000 452,966,000 192,964,000 214,415,000 236,351,000  
        total liabilities and shareholders’ equity
      		1,508,124,000 1,583,918,000 832,159,000 816,443,000 866,549,000 903,330,000 933,217,000 947,029,000 457,225,000      
        liabilities, redeemable convertible preferred shares and shareholders’ equity
      		              
        series a redeemable convertible preferred shares – 0.0001 par value...
      		             32,001,000 
        series a+ redeemable convertible preferred shares – 0.0001 par value...
      		             26,000,000 
        series b redeemable convertible preferred stock – 0.0001 par value...
      		             133,015,000 
        series b‑1 redeemable convertible preferred stock – 0.0001 par value...
      		             8,959,000 
        shareholders’ equity
      		              
        undesignated shares – 0.0001 par value...
      		              
        total liabilities, redeemable convertible preferred shares and shareholders’ equity
      		         482,017,000 216,370,000 229,428,000 247,353,000  
        non-voting ordinary shares – 0.0001 par value...
      		          1,000 1,000   
        accumulated other comprehensive loss
      		          -310,000 -390,000  -110,000 
        liabilities, redeemable convertible preferred shares and shareholders’ deficit
      		              
        shareholders’ deficit:
      		              
        total shareholders’ deficit
      		             -115,140,000 
        total liabilities, redeemable convertible preferred shares and shareholders’ deficit
      		             97,845,000 
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2026-03-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 
                    
          cash flows from operating activities
        		            
          net loss
        		-75,968,000 -65,712,000 -61,661,000 -46,833,000 -36,479,000 -33,977,000 -26,034,000 -26,036,000 -24,503,000 -23,862,000 -23,280,000 -17,975,000 
          adjustments to reconcile net loss to net cash from operating activities:
        		            
          share-based compensation expense
        		11,639,000 7,495,000 7,509,000 5,918,000 5,831,000 6,023,000 4,196,000 2,744,000    2,533,000 
          depreciation expense
        		576,000 356,000 291,000 274,000 273,000 265,000 232,000 222,000     
          accretion of asset retirement obligation
        		10,000    -7,000    17,000    
          non-cash lease expense
        		639,000 621,000 560,000 412,000 474,000 258,000 431,000 438,000 190,000 272,000 88,000 84,000 
          accretion of net investment discounts
        		-3,246,000 -3,291,000 -4,340,000 -5,197,000 -6,025,000 -5,979,000 -3,184,000 -3,277,000 -2,324,000    
          changes in operating assets and liabilities:
        		            
          other receivable
        		100,000,000            
          prepaid expenses and other current assets
        		-7,988,000 -2,177,000 -62,000 -5,047,000 672,000 2,137,000 2,409,000 -6,626,000 -1,750,000 -900,000 1,658,000 -3,045,000 
          other non-current assets
        		-4,838,000 -397,000 -106,000 -990,000 -3,284,000 4,000 -1,779,000 -2,000 -7,000 0 81,000 -59,000 
          accounts payable
        		-4,967,000 8,806,000 280,000 686,000 -423,000 6,301,000 -4,390,000 1,819,000 1,398,000 -2,380,000 1,045,000 -923,000 
          accrued expenses and other current liabilities
        		-134,000 3,881,000 3,604,000 -993,000 3,024,000 5,550,000 2,177,000 -3,034,000 3,151,000 6,090,000 3,477,000 -555,000 
          operating lease liabilities
        		-695,000 -601,000 -633,000 -459,000 -523,000 -289,000 -451,000 -328,000 -71,000 -57,000 -95,000 -92,000 
          other non-current liabilities
        		206,000            
          net cash from operating activities
        		15,234,000 -50,996,000 -54,558,000 -52,229,000 -36,467,000 -19,696,000 -26,393,000 -34,080,000 -21,729,000 -20,557,000 -16,894,000 -20,308,000 
          capital expenditures
        		-1,182,000 -1,572,000 -232,000 -314,000 -16,000 -685,000 -427,000 -162,000 -1,420,000 -820,000 0  
          free cash flows
        		14,052,000 -52,568,000 -54,790,000 -52,543,000 -36,483,000 -20,381,000 -26,820,000 -34,242,000 -23,149,000 -21,377,000 -16,894,000  
          cash flows from investing activities
        		            
          purchases of short-term investments
        		-647,468,000 -248,824,000 -88,826,000 -116,106,000 -132,252,000 -254,759,000 -283,588,000 -31,920,000 -236,588,000 -14,932,000 24,260,000 -190,096,000 
          proceeds from maturities of short-term investments
        		151,703,000 195,919,000 138,000,000 150,453,000         
          purchases of property and equipment
        		-1,182,000 -1,572,000 -232,000 -314,000 -16,000 -685,000 -427,000 -162,000 -1,156,000 -820,000   
          net cash from investing activities
        		-496,947,000 -49,319,000 48,942,000 34,033,000 33,232,000 -189,044,000 -204,515,000 1,418,000 -180,744,000 30,129,000 -68,711,000 -49,016,000 
          cash flows from financing activities
        		            
          payments of offering costs
        		-37,000    0 -1,154,000 -589,000 -53,000     
          proceeds from exercise of share options
        		869,000 377,000 43,000 965,000 224,000 397,000 478,000 755,000 117,000 473,000 179,000 31,000 
          payment of taxes on restricted share units withheld for taxes
        		-2,574,000 -462,000 0 -156,000         
          net cash from financing activities
        		-1,742,000 56,203,000 517,000 809,000 615,000 -757,000 514,703,000 702,000 281,629,000 473,000 -297,000 169,726,000 
          net change in cash and cash equivalents
        		-483,455,000 -44,112,000 -5,099,000 -17,387,000 -2,620,000 -209,497,000 283,795,000 -31,960,000 79,156,000 10,045,000 -85,902,000 100,402,000 
          cash and cash equivalents
        		            
          beginning of the period
        		799,623,000 0 0 169,510,000 0 0 0 129,792,000 0 0 0 26,091,000 
          end of the period
        		316,168,000 -44,112,000 -5,099,000 152,123,000 -2,620,000 -209,497,000 283,795,000 97,832,000 79,156,000 10,045,000 -85,902,000 126,493,000 
          supplemental disclosures of noncash investing and financing activities
        		            
          offering costs included in accounts payable and accrued expenses and other current liabilities
        		405,000   100,000 0 -1,154,000       
          operating lease right-of-use assets obtained in exchange for new lease liabilities
        		 0 731,000 4,190,000     1,673,000    
          advance payment received for sale of non-financial asset
        		            
          proceeds from atm offering, net of sales commission
        		            
          proceeds from issuance of ordinary shares in follow-on offering, net of underwriting discounts and commissions
        		    0 0       
          proceeds from issuance of ordinary shares under employee share purchase plan
        		 0   391,000 0       
          depository issuance cost offset
        		            
          proceeds from issuance of ordinary shares in initial public offering, net of underwriting discounts and commissions
        		            
          proceeds from private placement financing, gross
        		            
          conversion of redeemable convertible preferred shares into ordinary shares upon initial public offering
        		        0 0 0 199,975,000 
          purchases of property and equipment in accounts payable and accrued expenses and other current liabilities
        		        -264,000    
          recognition of asset retirement obligation
        		        0    
          conversion of non-voting ordinary shares into ordinary shares
        		            
          exchange of ordinary shares to non-voting ordinary shares
        		        0 0   
          maturities of short-term investments
        		     66,400,000 79,500,000 33,500,000 57,000,000 45,881,000 -92,780,000 141,080,000 
          proceeds from issuance of common stock in initial public offering, net of underwriting discount and commissions
        		        0 0   
          proceeds from issuance of series b redeemable convertible preferred shares, net of issuance costs
        		            
          repurchases of restricted shares
        		            
          deferred offering costs included in accounts payable and accrued expenses and other current liabilities
        		        -259,000   416,000 
          accretion of redeemable convertible preferred shares to their redemption value
        		            
          share-based compensation
        		         1,858,000   
          depreciation
        		         79,000 74,000 70,000 
          payments of deferred offering costs
        		         0 -476,000 -2,601,000 
          amortization of net investment premiums
        		            
          deferred tax liability
        		            
          accretion of net investment premium
        		           -346,000 
          proceeds from issuance of common stock in initial public offering, net of underwriter discount and commissions
        		           172,296,000 
          amortization of net investment premium
        		            
          amortization of debt discount and issuance costs
        		            
          proceeds from issuance of series seed redeemable convertible preferred shares of basecamp to noncontrolling interest holders
        		            
          repurchases of unvested restricted share awards
        		            
          payment of series b-1 redeemable convertible preferred shares issuance costs
        		            
          issuance of series b-1 redeemable convertible preferred stock to noncontrolling interest holders in exchange of series seed redeemable convertible preferred stock of basecamp