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operating activities:
net income	3,052,000,000	1,960,000,000	1,315,000,000	1,783,000,000	1,253,000,000	1,614,000,000	-4,170,000,000	1,417,000,000	2,172,000,000	1,039,000,000	985,000,000	1,633,000,000	1,786,000,000	1,135,000,000	12,000,000	376,000,000	2,586,000,000	1,517,000,000	1,722,000,000	1,544,000,000	353,000,000	-3,346,000,000	1,538,000,000	2,689,000,000	-1,168,000,000	1,875,000,000	1,968,000,000	3,000,000	2,099,000,000	1,819,000,000	1,539,000,000	-3,836,000,000	2,712,000,000	3,069,000,000	2,699,000,000	3,099,000,000	3,325,000,000	3,497,000,000	3,567,000,000	4,685,000,000	4,592,000,000	4,497,000,000	4,332,000,000	3,461,665,000	2,724,263,000	3,650,485,000	2,222,587,000	786,742,000	758,959,000	671,035,000	706,074,000	437,531,000	661,759,000	737,538,000	742,459,000	647,303,000	626,365,000	702,163,000	709,127,000	852,094,000	799,393,000	670,478,000	569,145,000	586,576,000	568,194,000	504,005,000	442,828,000	496,127,000
adjustments to reconcile net income to net cash from operating activities:
depreciation expense	90,000,000	93,000,000	97,000,000	95,000,000	94,000,000	98,000,000	94,000,000	91,000,000	86,000,000	83,000,000	94,000,000	83,000,000	80,000,000	80,000,000	80,000,000	90,000,000	82,000,000	79,000,000	78,000,000	79,000,000	73,000,000	68,000,000	68,000,000	69,000,000	66,000,000	60,000,000	60,000,000	57,000,000	57,000,000	56,000,000	56,000,000	78,000,000	52,000,000	54,000,000	49,000,000	48,000,000	44,000,000	43,000,000	42,000,000	45,000,000	41,000,000	38,000,000	37,000,000	31,331,000	40,190,000	28,969,000	24,510,000	26,598,000	22,359,000	20,551,000	20,227,000	19,710,000	18,955,000	17,202,000	17,745,000	18,285,000	17,865,000	15,989,000	15,908,000	17,478,000
amortization expense	596,000,000	598,000,000	599,000,000	598,000,000	596,000,000	596,000,000	596,000,000	597,000,000	598,000,000	598,000,000	546,000,000	445,000,000	445,000,000	445,000,000	445,000,000	445,000,000	441,000,000	440,000,000	395,000,000	348,000,000	282,000,000	281,000,000	281,000,000	281,000,000	281,000,000	288,000,000	299,000,000	301,000,000	301,000,000	300,000,000	301,000,000	319,000,000	245,000,000	244,000,000	245,000,000	244,000,000	255,000,000	241,000,000	241,000,000	233,000,000	237,000,000	235,000,000	232,000,000	244,050,000	226,482,000	237,938,000	216,530,000	101,361,000	51,272,000	50,445,000	47,185,000	46,457,000	54,470,000	55,799,000	57,147,000	62,629,000	59,652,000	53,064,000	42,893,000	42,628,000
stock-based compensation expense	230,000,000	225,000,000	209,000,000	222,000,000	216,000,000	210,000,000	187,000,000	201,000,000	202,000,000	198,000,000	165,000,000	174,000,000	168,000,000	165,000,000	130,000,000	159,000,000	171,000,000	166,000,000	139,000,000	161,000,000	173,000,000	168,000,000	141,000,000	157,000,000	162,000,000	174,000,000	143,000,000	175,000,000	198,000,000	252,000,000	220,000,000	334,000,000	113,000,000	102,000,000	89,000,000	102,000,000	95,000,000	95,000,000	88,000,000	97,000,000	97,000,000	96,000,000	92,000,000	95,417,000	99,307,000	83,095,000	82,181,000	71,691,000	57,127,000	54,464,000	48,403,000	48,731,000												41,045,000	38,759,000	41,594,000	36,875,000	36,136,000
deferred income taxes	659,000,000	-178,000,000	-199,000,000	-379,000,000	-576,000,000	-166,000,000	-723,000,000	-370,000,000	-68,000,000	-221,000,000	-303,000,000	-338,000,000	-270,000,000	-293,000,000	-651,000,000	-359,000,000	240,000,000	-68,000,000	71,000,000	-202,000,000	-121,000,000	53,000,000	56,000,000	-1,302,000,000	-824,000,000	4,000,000	24,000,000	279,000,000	12,000,000	-37,000,000	35,000,000	-209,000,000	-11,000,000	80,000,000	58,000,000	-24,000,000	21,000,000	-131,000,000	15,000,000	49,000,000	-182,000,000	-139,000,000	-121,000,000	-168,939,000	-13,518,000	-50,222,000	-3,321,000	-85,781,000	-60,767,000	-592,000	-29,419,000	51,385,000	20,646,000	3,407,000	19,462,000	20,546,000	-30,568,000	12,824,000	-1,164,000	31,060,000	-53,352,000	-9,070,000	9,104,000	11,305,000	-38,136,000	23,935,000	788,000	9,332,000
net (gain) income from equity securities
acquired in-process research and development expenses	170,000,000	62,000,000	253,000,000	-11,000,000	505,000,000	38,000,000	4,131,000,000	347,000,000	91,000,000	236,000,000	481,000,000	158,000,000	448,000,000			0	19,000,000	96,000,000	62,000,000	64,000,000	1,171,000,000
in-process research and development impairments	0
other	89,000,000	33,000,000	91,000,000	59,000,000	86,000,000	89,000,000	119,000,000	566,000,000	55,000,000	142,000,000	63,000,000	234,000,000	126,000,000	230,000,000	190,000,000	616,000,000	25,000,000	375,000,000	201,000,000	40,000,000	80,000,000	71,000,000	59,000,000	25,000,000	93,000,000	223,000,000	-157,000,000	42,000,000	-135,000,000	100,000,000	49,000,000	77,000,000	38,000,000	150,000,000	39,000,000	-9,000,000	-8,000,000	12,000,000	-19,000,000	-58,000,000	7,000,000	32,000,000	-5,000,000	24,209,000	33,378,000	18,293,000	3,120,000	2,173,000	159,000	-3,101,000
changes in operating assets and liabilities:
accounts receivable	-333,000,000	-292,000,000	79,000,000	72,000,000	162,000,000	-29,000,000	-66,000,000	220,000,000	-612,000,000	-86,000,000	635,000,000	-281,000,000	-372,000,000	-452,000,000	699,000,000	41,000,000	-422,000,000	-281,000,000	975,000,000	-837,000,000	-702,000,000	744,000,000	-376,000,000	-251,000,000	101,000,000	-100,000,000	32,000,000	113,000,000	90,000,000	176,000,000	101,000,000	281,000,000	355,000,000	-419,000,000	537,000,000	422,000,000	580,000,000	381,000,000	-191,000,000	213,000,000	-800,000,000	-462,000,000	-348,000,000	-1,751,030,000	505,425,000	-214,775,000	-1,117,620,000	-88,991,000	37,155,000	-19,336,000	376,698,000	-196,531,000	-154,343,000	573,000	-114,090,000	-107,876,000	3,206,000	-109,700,000	-78,467,000	-163,914,000	-66,449,000	-72,102,000	-128,838,000	-89,073,000	1,925,000	-75,135,000	-42,929,000	-141,022,000
inventories	-515,000,000	-175,000,000	-223,000,000	-226,000,000	-85,000,000	-70,000,000	-45,000,000	-307,000,000	-82,000,000	-226,000,000	-227,000,000	-276,000,000	-95,000,000	8,000,000	53,000,000	35,000,000	70,000,000	-25,000,000	-69,000,000	-147,000,000	-26,000,000	-37,000,000	15,000,000	-60,000,000	-23,000,000	3,000,000	-15,000,000	-119,000,000	-157,000,000	-20,000,000	-14,000,000	-174,000,000	-65,000,000	-9,000,000	-5,000,000	-214,000,000	-177,000,000	-83,000,000	-14,000,000	-196,000,000	-25,000,000	-264,000,000	-370,000,000	42,172,000	121,691,000	63,748,000	-84,611,000	-126,493,000	-125,182,000	-11,552,000	-186,357,000	-26,833,000	-64,109,000	-22,040,000	-17,470,000	-97,174,000	67,073,000	89,280,000	-142,558,000	-174,985,000	-35,246,000	-46,892,000	18,767,000	-11,895,000	-32,344,000	-44,002,000	-196,260,000	-58,120,000
prepaid expenses and other	-368,000,000	81,000,000	12,000,000	-146,000,000	-57,000,000	-19,000,000	-37,000,000	-32,000,000	5,000,000	40,000,000	26,000,000	58,000,000	42,000,000	-10,000,000	-20,000,000	-25,000,000	-15,000,000	6,000,000	-8,000,000	-236,000,000	-54,000,000	30,000,000	46,000,000	-82,000,000	-191,000,000	9,000,000	-43,000,000	154,000,000	127,000,000	93,000,000	529,000,000	47,000,000	166,000,000	-32,000,000	177,000,000	265,000,000	-450,000,000
accounts payable	230,000,000	-162,000,000	-105,000,000	-58,000,000	359,000,000	-83,000,000	72,000,000	-43,000,000	-29,000,000	-3,000,000	-272,000,000	264,000,000	66,000,000	-13,000,000	-91,000,000	124,000,000	-20,000,000	31,000,000	-253,000,000	214,000,000	-21,000,000	-4,000,000	-109,000,000	81,000,000	24,000,000	35,000,000	-201,000,000	178,000,000	-24,000,000	-101,000,000	-92,000,000	85,000,000	-116,000,000	-137,000,000	-262,000,000	162,000,000	-48,000,000	172,000,000	-239,000,000	-62,000,000	-332,000,000	562,000,000	58,000,000	-214,401,000	15,346,000	-69,828,000	-20,117,000	-120,804,000	-28,973,000	-84,156,000	122,962,000	107,652,000	171,139,000	-37,843,000	119,534,000	176,114,000	-146,145,000	-120,570,000	120,535,000	141,727,000	68,429,000	91,521,000	64,690,000	-20,999,000	-28,894,000	26,963,000	209,825,000	104,674,000
income tax assets and liabilities	-122,000,000	-1,300,000,000	-552,000,000	536,000,000	111,000,000	-1,171,000,000	-208,000,000	-698,000,000	-881,000,000	-28,000,000	-161,000,000
accrued and other liabilities	811,000,000	-166,000,000	-244,000,000	305,000,000	152,000,000	-174,000,000	-175,000,000	317,000,000	50,000,000	634,000,000	-543,000,000		164,000,000	362,000,000	-1,657,000,000		-138,000,000	25,000,000	-738,000,000
net cash from operating activities	4,108,000,000	827,000,000	1,757,000,000	2,975,000,000	4,309,000,000	1,325,000,000	2,219,000,000	2,169,000,000	1,755,000,000	2,338,000,000	1,744,000,000	2,567,000,000	2,863,000,000	1,802,000,000	1,840,000,000	3,205,000,000	3,253,000,000	2,316,000,000	2,610,000,000	1,916,000,000	2,250,000,000	2,566,000,000	1,436,000,000	2,580,000,000	2,899,000,000	2,221,000,000	1,444,000,000	2,345,000,000	2,212,000,000	1,573,000,000	2,270,000,000	2,753,000,000	2,694,000,000	3,526,000,000	2,925,000,000	3,486,000,000	4,330,000,000	4,940,000,000	3,913,000,000	4,874,000,000	4,096,000,000	5,658,000,000	5,701,000,000	3,020,667,000	4,044,022,000	4,185,293,000	1,568,018,000	726,787,000	705,728,000	745,368,000	1,290,651,000	452,969,000	978,107,000	897,106,000	943,255,000	820,542,000	724,843,000	739,422,000	699,079,000	670,569,000	955,276,000	860,531,000	622,917,000	641,330,000	646,030,000	555,217,000	426,314,000	577,098,000
investing activities:
purchases of marketable debt securities	-270,000,000			0	0	0	-244,000,000	-456,000,000	-369,000,000	-578,000,000	-527,000,000	-372,000,000	-308,000,000	-477,000,000	-613,000,000	-626,000,000	-813,000,000	-1,147,000,000	-931,000,000	-506,000,000	-3,056,000,000	-3,595,000,000	-13,158,000,000	-6,398,000,000	-7,035,000,000	-10,300,000,000	-6,722,000,000
proceeds from sales of marketable debt securities	219,000,000			0	0	0	2,265,000,000	98,000,000	95,000,000	150,000,000	167,000,000	42,000,000	47,000,000	204,000,000	119,000,000	224,000,000	255,000,000	191,000,000	60,000,000	10,872,000,000	1,941,000,000	770,000,000	9,656,000,000	3,001,000,000	2,958,000,000	989,000,000	575,000,000
proceeds from maturities of marketable debt securities	17,000,000			0	0	0	327,000,000	349,000,000	266,000,000	395,000,000	324,000,000	358,000,000	277,000,000	449,000,000	506,000,000	372,000,000	558,000,000	631,000,000	619,000,000	951,000,000	2,301,000,000	2,778,000,000	3,449,000,000	4,759,000,000	7,610,000,000	3,518,000,000	6,511,000,000
acquisitions, including in-process research and development, net of cash acquired	-167,000,000	-21,000,000	-273,000,000	-75,000,000	-570,000,000	-152,000,000	-4,043,000,000	-279,000,000	-79,000,000	-243,000,000	-551,000,000	-218,000,000	-448,000,000	-1,101,000,000	-30,000,000	-1,000,000	-54,000,000	-92,000,000	-1,255,000,000	-19,938,000,000	-1,000,000,000
purchases of equity securities	-82,000,000	-21,000,000	-16,000,000	-39,000,000	-9,000,000	-34,000,000	-410,000,000	-224,000,000	-26,000,000	-67,000,000	-125,000,000	-6,000,000	-122,000,000	-16,000,000	-28,000,000	-48,000,000	-31,000,000	-22,000,000	-279,000,000	-67,000,000	-302,000,000	-78,000,000	-8,000,000	-522,000,000
purchases of property, plant and equipment	-147,000,000	-107,000,000	-104,000,000
other investing activities	4,000,000	10,000,000	-23,000,000
net cash from investing activities	-427,000,000	-2,116,000,000	-415,000,000	-225,000,000	-710,000,000	-307,000,000	-2,207,000,000	-727,000,000	-229,000,000	-483,000,000	-826,000,000	-375,000,000	-713,000,000	-308,000,000	-1,070,000,000		-234,000,000	-577,000,000	-2,042,000,000	-8,977,000,000	-271,000,000	-5,023,000,000	-344,000,000	431,000,000	-2,095,000,000	-6,042,000,000	-111,000,000	2,735,000,000	2,025,000,000	5,241,000,000	4,354,000,000	-10,016,000,000	-2,114,000,000	-4,246,000,000	307,000,000	-2,675,000,000	-3,917,000,000	-3,284,000,000	-2,109,000,000	-2,438,000,000	-4,186,000,000	-3,552,000,000	-2,299,000,000	-404,759,000	-770,053,000	-487,248,000	-160,940,000	216,410,000	50,070,000	-518,044,000	-634,964,000	-10,743,116,000	4,440,336,000	-80,320,000	-469,790,000	-300,381,000	-407,816,000	-1,394,129,000	932,972,000	-1,068,778,000	-397,684,000	-426,649,000	-1,063,178,000	-328,389,000	238,575,000	-319,078,000	24,900,000	-123,216,000
financing activities:
proceeds from issuances of common stock	97,000,000	27,000,000	252,000,000	173,000,000	98,000,000	5,000,000	146,000,000	26,000,000	83,000,000	26,000,000	97,000,000	176,000,000	36,000,000	3,000,000	94,000,000	12,000,000	57,000,000	12,000,000	88,000,000	8,000,000	36,000,000	35,000,000	177,000,000	27,000,000	41,000,000	38,000,000	103,000,000	50,000,000	80,000,000	48,000,000	111,000,000	51,000,000	64,000,000	23,000,000	96,000,000	28,000,000	60,000,000	28,000,000	92,000,000	38,000,000	79,000,000	84,000,000	118,000,000	55,926,000	112,156,000	54,191,000	108,727,000	72,408,000	116,019,000	148,473,000	69,261,000	132,530,000	53,503,000	42,322,000	57,033,000	58,879,000	54,397,000	22,535,000	40,929,000	103,362,000	61,804,000	58,831,000	61,146,000	40,947,000	69,709,000	40,852,000	70,084,000	65,480,000
repurchases of common stock under repurchase programs	-435,000,000	-527,000,000	-730,000,000	-350,000,000	-300,000,000	-100,000,000	-400,000,000	-150,000,000	-300,000,000	-150,000,000	-400,000,000
repayments of debt and other obligations	-9,000,000	-9,000,000	-1,762,000,000	-7,000,000	-112,000,000			0				0	-1,000,000,000	0	-500,000,000	-1,000,000,000	-2,500,000,000	0	-1,250,000,000	0	-2,000,000,000	0	-500,000,000	0	-1,500,000,000	-500,000,000	-750,000,000	0	-1,750,000,000	0	-4,500,000,000	-1,721,000,000	-30,000,000	-30,000,000	-30,000,000	-730,000,000	-5,000,000	-1,120,000,000	-126,000,000	-234,000,000	-113,000,000
payments of dividends	-1,005,000,000	-994,000,000	-1,010,000,000	-973,000,000	-983,000,000	-972,000,000	-990,000,000	-943,000,000	-953,000,000	-944,000,000	-969,000,000		-929,000,000	-920,000,000	-945,000,000		-900,000,000	-894,000,000	-917,000,000		-861,000,000	-856,000,000	-874,000,000		-804,000,000	-800,000,000	-817,000,000		-742,000,000	-740,000,000	-753,000,000		-682,000,000	-680,000,000	-687,000,000		-623,000,000	-626,000,000	-587,000,000
other financing activities	-137,000,000	-64,000,000	-176,000,000
net cash from financing activities	-1,489,000,000	-1,567,000,000	-3,426,000,000	2,260,000,000	-1,379,000,000	-2,953,000,000	-1,361,000,000	-1,099,000,000	-1,519,000,000	-1,101,000,000	-1,406,000,000	-1,554,000,000	-2,118,000,000	-1,003,000,000	-1,794,000,000	-1,942,000,000	-3,527,000,000	-931,000,000	-2,477,000,000	131,000,000	4,124,000,000	-874,000,000	-2,611,000,000	-896,000,000	-2,515,000,000	-1,857,000,000	-2,366,000,000	-1,670,000,000	-2,901,000,000	-1,152,000,000	-6,595,000,000	3,347,000,000	2,170,000,000	-880,000,000	-1,244,000,000	-2,295,000,000	2,860,000,000	-1,516,000,000	-8,396,000,000	-3,544,000,000	6,644,000,000	-5,341,000,000	-2,722,000,000	1,233,876,000	-5,771,421,000	-1,371,591,000	2,884,136,000	-845,059,000	-509,851,000	-307,514,000	-474,879,000	1,855,590,000	3,526,620,000	-876,199,000	-1,371,962,000	485,110,000	-459,656,000	270,450,000	-1,165,536,000	16,032,000	-324,079,000	-425,325,000	-156,293,000	-145,741,000	-648,166,000	-177,655,000	-48,714,000	-661,309,000
effect of exchange rate changes on cash and cash equivalents	-5,000,000	73,000,000	19,000,000	-55,000,000	44,000,000	-11,000,000	-18,000,000	37,000,000	-6,000,000	13,000,000	13,000,000	75,000,000	-72,000,000	-48,000,000	-18,000,000	-9,000,000	-23,000,000	20,000,000	-23,000,000	41,000,000	37,000,000	26,000,000	-61,000,000	42,000,000	-55,000,000	-9,000,000	20,000,000	-39,000,000	-1,000,000	-71,000,000	26,000,000	-4,000,000	46,000,000	27,000,000	68,000,000	-96,000,000	51,000,000	30,000,000	56,000,000	-6,000,000	-6,000,000	17,000,000	-72,000,000	-32,038,000
net change in cash and cash equivalents	2,187,000,000	-2,783,000,000	-2,065,000,000	4,955,000,000	2,264,000,000	-1,946,000,000	-1,367,000,000	380,000,000	1,000,000	768,000,000	-476,000,000	713,000,000	-40,000,000	443,000,000	-1,042,000,000	976,000,000	-531,000,000	828,000,000	-1,932,000,000	-6,889,000,000	6,140,000,000	-3,305,000,000	-1,580,000,000	2,157,000,000	-1,766,000,000	-5,687,000,000	-1,013,000,000	3,371,000,000	1,335,000,000	5,591,000,000	55,000,000	-3,920,000,000	2,796,000,000	-1,573,000,000	2,056,000,000	-1,580,000,000	3,324,000,000	170,000,000	-6,536,000,000	-1,114,000,000	6,548,000,000	-3,218,000,000	608,000,000	3,817,746,000	-2,521,462,000	2,326,369,000	4,291,347,000	102,070,000	252,984,000	-74,790,000	173,558,000	-8,431,835,000	8,974,418,000	3,580,000	-930,199,000	928,099,000	-115,114,000	-459,646,000	545,759,000	-336,078,000	248,359,000	-16,275,000	-622,772,000	204,344,000	249,878,000	89,825,000	396,715,000	-245,202,000
cash and cash equivalents at beginning of period	0	0	9,991,000,000	0	0	0	6,085,000,000	0	0	0	5,412,000,000	0	0	0	5,338,000,000	0	0	0	5,997,000,000	0	0	0	11,631,000,000	0	0	0	17,940,000,000	0	0	0	7,588,000,000	0	0	0	8,229,000,000	0	0	0	12,851,000,000	0	0	0	10,027,000,000	194,000	0	0	2,112,806,000	0	0	0	0	9,883,777,000	0	0	0	907,879,000	0	0	0	1,272,958,000	0	0	0	1,459,302,000	0	0	0	968,086,000
cash and cash equivalents at end of period	2,186,000,000	-2,782,000,000	7,926,000,000	4,954,000,000	2,265,000,000	-1,946,000,000	4,718,000,000	380,000,000	1,000,000	768,000,000	4,936,000,000	713,000,000	-40,000,000	443,000,000	4,296,000,000	976,000,000	-531,000,000	828,000,000	4,065,000,000	-6,889,000,000	6,140,000,000	-3,305,000,000	10,051,000,000	2,157,000,000	-1,766,000,000	-5,687,000,000	16,927,000,000	3,371,000,000	1,335,000,000	5,591,000,000	7,643,000,000	-3,920,000,000	2,796,000,000	-1,573,000,000	10,285,000,000	-1,580,000,000	3,324,000,000	170,000,000	6,315,000,000	-1,114,000,000	6,548,000,000	-3,218,000,000	10,635,000,000	3,817,940,000	-2,521,462,000	2,326,369,000	6,404,153,000	102,070,000	252,984,000	-74,790,000	173,558,000	1,451,942,000	8,974,418,000	3,580,000	-930,199,000	1,835,978,000	-115,114,000	-459,646,000	545,759,000	936,880,000	248,359,000	-16,275,000	-622,772,000	1,663,646,000	249,878,000	89,825,000	396,715,000	722,884,000
net income from equity securities		-142,000,000	426,000,000	126,000,000	-257,000,000	391,000,000	14,000,000	-189,000,000	169,000,000	-69,000,000	256,000,000	61,000,000	197,000,000	303,000,000	96,000,000
capital expenditures				-147,000,000	-141,000,000	-130,000,000	-105,000,000	-215,000,000	-122,000,000	-139,000,000	-109,000,000	-181,000,000	-157,000,000	-143,000,000	-247,000,000	-156,000,000	-139,000,000	-119,000,000	-165,000,000	-181,000,000	-155,000,000	-143,000,000	-171,000,000	-203,000,000	-200,000,000	-185,000,000	-237,000,000	-248,000,000	-167,000,000	-297,000,000	-212,000,000	-220,000,000	-129,000,000	-123,000,000	-118,000,000	-169,000,000	-198,000,000	-204,000,000	-177,000,000	-166,000,000	-286,000,000	-171,000,000	-124,000,000	-167,451,000	-135,062,000	-90,997,000	-163,490,000	-69,472,000	-269,871,000	-66,584,000	-37,392,000	-23,199,000								-11,666,000
free cash flows				2,828,000,000	4,168,000,000	1,195,000,000	2,114,000,000	1,954,000,000	1,633,000,000	2,199,000,000	1,635,000,000	2,386,000,000	2,706,000,000	1,659,000,000	1,593,000,000	3,049,000,000	3,114,000,000	2,197,000,000	2,445,000,000	1,735,000,000	2,095,000,000	2,423,000,000	1,265,000,000	2,377,000,000	2,699,000,000	2,036,000,000	1,207,000,000	2,097,000,000	2,045,000,000	1,276,000,000	2,058,000,000	2,533,000,000	2,565,000,000	3,403,000,000	2,807,000,000	3,317,000,000	4,132,000,000	4,736,000,000	3,736,000,000	4,708,000,000	3,810,000,000	5,487,000,000	5,577,000,000	2,853,216,000	3,908,960,000	4,094,296,000	1,404,528,000	657,315,000	435,857,000	678,784,000	1,253,259,000	429,770,000								658,903,000
proceeds from debt financing, net of issuance costs								1,000,000												995,000,000												5,994,000,000				0	4,944,000,000			0				3,966,554,000	-86,000	-2,382,000	3,967,914,000
supplemental disclosure of cash flow information:
interest paid, net of amounts capitalized
income taxes paid
in-process research and development impairment					1,750,000,000	0	2,430,000,000					0	0	0	2,700,000,000																					201,000,000	117,000,000	0	114,000,000
income taxes payable												-4,000,000	78,000,000	-496,000,000	-146,000,000	99,000,000	72,000,000	-219,000,000	-316,000,000	-350,000,000	-67,000,000	-234,000,000	-127,000,000	165,000,000	381,000,000	-25,000,000	-249,000,000	92,000,000	287,000,000	-1,220,000,000	-618,000,000	5,545,000,000	-120,000,000	96,000,000	-24,000,000	-19,000,000	384,000,000	440,000,000	205,000,000	-254,000,000	-51,000,000	425,000,000	149,000,000	397,328,000	-161,998,000	56,697,000	240,973,000	117,102,000	7,201,000	26,419,000	-2,942,000	-99,151,000	25,594,000	33,592,000	20,112,000	31,473,000	-50,234,000	29,348,000	-15,128,000	-149,719,000	47,713,000	68,561,000	-545,000	50,605,000	-32,771,000	-14,695,000	8,989,000	14,590,000
accrued liabilities																												-190,000,000	-643,000,000	155,000,000	164,000,000	206,000,000	-675,000,000	328,000,000	-677,000,000	-632,000,000	181,000,000	681,000,000	195,000,000	15,000,000	572,000,000	515,000,000	1,530,000,000	756,495,000	379,443,000	710,799,000	166,263,000	45,863,000	-11,768,000	120,887,000	166,542,000	110,402,000	194,101,000	7,951,000	37,127,000	61,414,000	22,950,000	66,024,000	12,325,000	18,766,000	29,699,000	95,274,000	-25,949,000	10,002,000	41,506,000	71,796,000	-47,130,000	70,104,000
repurchases of common stock												-792,000,000	-180,000,000	-72,000,000	-352,000,000	-49,000,000	-145,000,000	-43,000,000	-309,000,000	0	-201,000,000	-54,000,000	-1,328,000,000	-105,000,000	-222,000,000	-588,000,000	-834,000,000	-962,000,000	-449,000,000	-450,000,000	-1,039,000,000	-106,000,000	-153,000,000	-130,000,000	-565,000,000	-1,000,000,000	-1,000,000,000	-1,001,000,000	-8,000,000,000	-3,051,000,000	-3,050,000,000	-900,000,000	-3,001,000,000	-2,000,523,000	-1,698,181,000	-1,200,209,000	-450,087,000	-400,099,000	-200,041,000	-205,209,000	-241,021,000	-20,770,000	-226,302,000	-883,968,000	-724,163,000	-548,699,000	-615,538,000	-1,552,974,000	-1,691,561,000	-162,520,000	-242,004,000	-288,247,000	-238,179,000	-230,065,000	-753,514,000	-250,079,000	-150,053,000	-815,936,000
payment of dividends
write-downs for slow-moving and excess raw material and work in process inventory
net cash from by investing activities
net incomees from equity securities																		174,000,000	351,000,000
net (gains) losses from equity securities
write-downs for slow moving and excess raw material and work in process inventory
net unrealized (gain) income from equity securities																					964,000,000
accrued liabilities and other																					145,000,000	463,000,000	-550,000,000		-236,000,000	-71,000,000	-417,000,000
net unrealized gain from equity securities																							283,000,000
up-front and milestone expense related to collaborative and other arrangements																							111,000,000	55,000,000
up-front and milestone payments related to collaborative and other arrangements																							-112,000,000	-20,000,000
net gains from equity securities
acquisitions, net of cash acquired																																																0	1,000	0	0	-10,751,636,000	0	0	-367,503,000	-221,105,000	0
net unrealized gains from equity securities
net unrealized (gains) losses from equity securities
inventory reserves for excess raw materials
purchases of marketable securities																												-4,447,000,000	-3,777,000,000	-1,612,000,000	-397,000,000	-4,501,000,000	-5,544,000,000	-9,787,000,000	-3,482,000,000	-5,738,000,000	-7,859,000,000	-7,045,000,000	-4,977,000,000	-4,948,000,000	-5,444,000,000	-4,385,000,000	-2,462,000,000	-574,574,000	-882,275,000	-555,811,000	-94,340,000	-2,043,000	-96,147,000	-541,673,000			-966,468,000	-1,447,232,000	-1,194,948,000	-1,519,142,000	-1,702,407,000	-1,784,129,000	-513,376,000	-1,502,775,000	-697,548,000	-726,221,000	-310,838,000	-879,439,000	-1,021,865,000	-943,647,000	-648,638,000	-658,962,000
proceeds from sales of marketable securities																												321,000,000	525,000,000	455,000,000	221,000,000	1,474,000,000	1,337,000,000	4,456,000,000	3,173,000,000	2,663,000,000	3,793,000,000	3,624,000,000	2,959,000,000	2,328,000,000	1,321,000,000	894,000,000	249,000,000	329,848,000	238,294,000	155,634,000	83,224,000	267,826,000	397,249,000	67,189,000	6,555,000	56,719,000	5,151,032,000	1,273,656,000	939,517,000	1,285,547,000	1,225,671,000	206,566,000	1,327,744,000	273,912,000	254,190,000	194,048,000	404,844,000	587,427,000	1,277,430,000	543,330,000	673,704,000	531,995,000
proceeds from maturities of marketable securities																												7,315,000,000	5,482,000,000	6,777,000,000	4,762,000,000	3,657,000,000	2,222,000,000	1,208,000,000	734,000,000	569,000,000	347,000,000	341,000,000	443,000,000	348,000,000	223,000,000	110,000,000	38,000,000	25,418,000	8,990,000	3,926,000	13,666,000	20,099,000	18,838,000	23,024,000			281,882,000	157,545,000	179,779,000	169,189,000	92,281,000	285,240,000	134,655,000	171,751,000	72,661,000	123,649,000	111,506,000	127,694,000	24,670,000	116,720,000	31,800,000	20,500,000
other investments																																				0	0	0	-357,000,000
proceeds from convertible note hedges																																				0	0	861,000,000	95,000,000	184,000,000	92,000,000	354,000,000	154,000,000	913,517,000	317,429,000	710,463,000	601,591,000	1,516,533,000
payments to settle warrants																																				0				0	0			-242,000				0
excess tax benefits from stock-based compensation																																				-32,000,000	-35,000,000	-38,000,000	-89,000,000	-87,000,000	-172,000,000	-140,000,000	-186,000,000	-124,072,000	-143,670,000	-57,563,000	-156,695,000	-110,045,000	-49,281,000	-29,516,000	-12,135,000	-23,304,000	-10,593,000	-9,957,000	-6,043,000	-14,255,000	-12,978,000	-7,953,000	-10,870,000	-49,819,000	-20,918,000	-25,585,000	-12,990,000	-20,693,000	-36,216,000	-35,128,000	-31,351,000	-89,244,000
tax benefits from exercise and vesting of stock-based awards																																				29,000,000	32,000,000	38,000,000	87,000,000	87,000,000	173,000,000	140,000,000	186,000,000	123,664,000	144,510,000
deferred revenues																																				-156,000,000	14,000,000	-199,000,000	37,000,000	30,000,000	-21,000,000	304,000,000	61,000,000	18,690,000	-7,521,000	16,565,000	3,266,000	-6,912,000	16,007,000	-3,556,000	-9,382,000	20,176,000	3,158,000	12,428,000	-36,699,000	-8,371,000	779,000	-20,646,000	-7,843,000	-2,018,000	71,818,000	-5,833,000	177,000	-17,559,000	20,786,000	-630,000	-4,450,000	9,375,000
purchases of convertible note hedges																																												249,000	0	0	-26,249,000										0
payment of contingent consideration																																				1,000,000	0			-1,000,000				-2,654,000
contributions from (distribution to) noncontrolling interest
contributions from (distributions to) noncontrolling interest																																											20,000,000		-34,315,000	28,949,000	-55,739,000	71,240,000	98,192,000			-73,595,000												22,720,000
contributions from noncontrolling interest																																						-42,000,000	41,000,000
prepaid expenses and other assets																																							-126,000,000	77,000,000	-40,000,000	-179,000,000	52,000,000	57,969,000	92,779,000	-352,368,000	-169,380,000	-59,156,000	-19,768,000	-77,221,000	42,847,000	-75,176,000	-27,332,000	2,489,000	34,787,000	-23,903,000	-64,648,000	-6,117,000	-6,006,000	6,305,000	-32,311,000	-43,956,000	10,702,000	-102,000	31,994,000	-25,280,000	-55,511,000	58,516,000
payment of dividend
net distributions to noncontrolling interest
change in fair value of contingent consideration																																											2,000,000	26,119,000	-12,085,000	5,288,000	2,678,000
repayments of debt and other long-term obligations																																											-199,000,000	-1,919,128,000	-420,990,000	-1,020,166,000	-1,418,716,000
effect of exchange rate changes on cash																																														-85,000	133,000	3,932,000	7,037,000	5,400,000	-7,250,000	2,722,000	29,355,000	62,993,000	-31,702,000	-77,172,000	27,515,000	-75,389,000	79,244,000	46,099,000	14,846,000	-24,832,000	-26,218,000	37,144,000	13,439,000	31,341,000	-5,785,000	-37,775,000
tax benefits from employee stock plans																																															157,654,000	114,739,000	51,228,000	30,597,000	12,651,000	18,153,000	10,657,000	8,778,000	5,660,000	12,136,000	12,146,000	7,218,000	11,057,000	51,665,000	22,125,000	27,407,000	15,232,000	23,604,000	40,191,000	39,956,000	35,839,000	93,533,000
in-process research and development impairment charges
purchases of other investments																																																	0	0	0	-25,000,000
repayments of debt financing																																																-2,215,167,000
repayments of other long-term obligations																																																-19,000	-19,000	-16,000	-1,539,000	-612,000		-52,000	-34,000	-1,533,000		-33,000	-5,537,000	-19,000		-5,527,000
proceeds from sale of warrants																																																									0
proceeds from issuances of senior notes, net of issuance costs																																																					3,673,332,000	0	0	987,370,000
proceeds from credit facilities, net of issuance costs																																																		0	0	1,146,844,000
proceeds from term loan, net of issuance costs																																																		0	0	997,889,000
repayments of term loan																																																		-300,000,000	-350,000,000	-350,000,000
repayments of credit facility																																																									0
repayments of convertible senior notes
distributions to noncontrolling interest																																																														-15,944,000
other non-cash transactions																																																				13,767,000	772,000	41,009,000	13,399,000	-7,249,000	30,029,000	-23,304,000	1,223,000	2,460,000	18,441,000	5,071,000	1,578,000	39,366,000	-23,538,000	-29,530,000	48,476,000	-15,229,000
stock-based compensation expenses																																																					46,603,000	46,180,000	50,125,000	49,470,000	53,351,000	51,802,000	48,047,000	46,841,000	41,824,000	48,606,000
capital expenditures and other																																																					-26,110,000	-64,289,000	-26,635,000	-14,870,000	-23,361,000	-10,806,000			-26,987,000	-18,125,000	-20,874,000	-164,071,000	-41,660,000	-31,398,000	-25,198,000	-16,749,000
proceeds from issuances of convertible notes, net of issuance costs																																																									0
proceeds from credit facility																																																									0	0			0	0
extinguishment of long-term debt																																																													-49,000	-23,000
repayments of long-term obligations
interest paid
repayment of convertible senior notes																																																						0
distributions (to) from noncontrolling interest																																																						-44,458,000	-60,854,000	-25,162,000
purchased in-process research and development expense																																																																		0
distributions from (to) noncontrolling interest																																																									88,704,000	37,666,000
acquisition of cv therapeutics, net of cash acquired																																																														0
extinguishment of long term debt
distributions from noncontrolling interest																																																												25,390,000
depreciation																																																													20,248,000	15,484,000	15,108,000	13,720,000	14,174,000	13,767,000	13,072,000	10,709,000
amortization																																																													43,862,000	41,567,000	37,527,000	25,428,000	12,657,000	20,900,000	11,158,000	6,030,000
purchases of non-marketable equity securities
repayment of credit facility
repayments of long-term debt and other obligations																																																																-36,000	-577,000	-3,556,000	-96,000	-97,000
acquisition of assets from navitas																																																																		-4,083,000
purchased in-process research and development
minority interest																																																																	67,743,000	36,701,000	-14,756,000	-28,413,000
proceeds from issuance of convertible senior notes, net of issuance costs
non-cash investing and financing activities:
reclassification of achillion equity investment from other noncurrent assets to marketable securities upon achillion’s initial public offering
acquisition of assets from nycomed

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