7Baggers

Galectin Therapeutics Inc
(NASDAQ:GALT) 

GALT stock logo

Galectin Therapeutics Inc., a clinical stage biopharmaceutical company, engages in the research and development of therapies for fibrotic, cancer, and other diseases. The company's lead product candidate is (GR-MD-02) belapectin galectin-3 inhibitor, a galactoarabino-rhamnogalacturonan polysaccharid...

Founded: 2000
Full Time Employees: 4
Sector: Healthcare
Industry: Biotechnology
Pharmaceuticals
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    Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 2009-12-31 2009-09-30 2009-06-30 2009-03-31 2008-12-31 2008-09-30 2008-06-30 2008-03-31 2007-12-31 2007-09-30 2007-06-30 2007-03-31 2006-12-31 2006-09-30 2006-06-30 2006-03-31 2005-12-31 2005-09-30 2005-06-30 2005-03-31 2004-12-31 2004-09-30 2004-06-30 2004-03-31 2003-12-31 2002-12-31 
                                                                                               
      operating expenses:
    		                                                                                           
      research and development
    		2,231,000 1,933,000 2,611,000 3,261,000 6,485,000 11,109,000 7,595,000 9,813,000 8,054,000 8,228,000 7,732,000 7,371,000 8,799,000 9,007,000 6,598,000 8,074,000 8,058,000 5,856,000 6,613,000 6,450,000 4,899,000 6,371,000 4,780,000 4,681,000 2,144,000 3,796,000 1,503,000 1,522,000 646,000 1,192,000 1,505,000 1,476,000 2,298,000 1,002,000 3,503,000 3,444,000 3,772,000 3,433,000 3,289,000 4,226,000 4,377,000 2,914,000 4,464,000 2,600,000 3,136,000 2,080,000 1,979,000 1,594,000 2,772,000 1,395,000 1,192,000 1,349,000 1,752,000 1,002,000 1,409,000 1,215,000 901,000 862,000 655,000 1,291,000 744,000 390,000 313,000 234,000 129,000 17,600,000 289,000 423,000 153,000 15,851,000 338,000 744,000 422,000 13,913,000 332,000 668,000 668,000 11,213,000 863,000 998,000 454,000 8,217,000 859,000 831,000 601,000 5,430,000 666,000 522,000 5,278,540   
      general and administrative
    		1,846,000 1,432,000 1,587,000 1,364,000 1,412,000 1,319,000 1,471,000 1,478,000 1,594,000 1,333,000 1,434,000 1,632,000 1,543,000 1,626,000 1,524,000 1,588,000 1,877,000 1,569,000 1,631,000 1,743,000 1,418,000 1,461,000 1,146,000 1,421,000 1,440,000 1,392,000 1,360,000 1,498,000 1,721,000 1,793,000 1,175,000 2,283,000 1,880,000 1,371,000 911,000 1,070,000 1,174,000 1,166,000 1,248,000 1,305,000 2,437,000 1,769,000 1,435,000 2,057,000 1,704,000 1,654,000 1,498,000 1,781,000 2,072,000 1,409,000 2,353,000 1,198,000 1,456,000 1,380,000 1,487,000 1,453,000 1,052,000 2,510,000 1,378,000 1,700,000 1,269,000 899,000 899,000 1,116,000 903,000 26,879,000 961,000 1,569,000 1,581,000 23,286,000 601,000 1,130,000 990,000 19,059,000 1,036,000 1,104,000 1,256,000 14,616,000 1,066,000 1,101,000 1,270,000 11,430,000 846,000 897,000 852,000 7,339,000 1,133,000 915,000 7,173,328   
      total operating expenses
    		4,077,000 3,365,000 4,198,000 4,625,000 7,897,000 12,428,000 9,066,000 11,291,000 9,648,000 9,561,000 9,166,000 9,003,000 10,342,000 10,633,000 8,122,000 9,662,000 9,935,000 7,425,000 8,244,000 8,193,000 6,317,000 7,832,000 5,926,000 6,102,000 3,584,000 5,188,000 2,863,000 3,020,000 2,367,000 2,985,000 2,680,000 3,759,000 4,178,000 2,373,000 4,414,000 4,514,000 4,946,000 4,599,000 4,537,000 5,531,000 6,814,000 4,683,000 5,899,000 4,657,000 4,840,000 3,734,000 3,477,000 3,375,000 4,844,000 2,804,000 3,545,000 2,547,000 3,208,000 2,382,000 2,896,000 2,668,000 1,953,000 3,372,000 2,033,000 2,991,000 2,013,000 1,289,000 1,212,000 1,350,000 1,032,000 44,479,000 1,250,000 1,992,000 1,734,000     -1,266,000 -1,368,000 -1,772,000  -1,438,000 -1,929,000 -2,099,000 -1,724,000 -19,647,000 -1,705,000 -1,728,000 -1,453,000 -12,769,000 -1,799,000 -1,437,000 -12,451,868   
      total operating loss
    		-4,077,000   -4,625,000 -7,897,000 -12,428,000 -9,066,000 -11,291,000 -9,648,000 -9,561,000 -9,166,000 -9,003,000 -10,342,000 -10,633,000 -8,122,000 -9,662,000 -9,935,000 -7,425,000 -8,244,000 -8,193,000 -6,317,000 -7,832,000 -5,926,000 -6,102,000 -3,584,000 -5,188,000 -2,863,000 -3,020,000 -2,367,000 -2,985,000 -2,680,000 -3,759,000 -4,178,000 -2,373,000 -4,414,000 -4,514,000 -4,946,000 -4,599,000 -4,537,000 -5,531,000 -6,814,000 -4,683,000 -5,899,000 -4,657,000 -4,840,000 -3,734,000 -3,477,000 -3,375,000 -4,844,000 -2,804,000 -3,545,000 -2,547,000 -3,208,000 -2,382,000 -2,896,000 -2,668,000 -1,953,000 -3,372,000 -2,033,000 -2,991,000 -2,013,000 -1,289,000 -1,212,000 -1,350,000 -1,032,000 -44,479,000 -1,250,000 -1,992,000 -1,734,000 -39,137,000 -939,000 -1,874,000 -1,412,000    -1,924,000               
      other income:
    		                                                                                           
      interest income
    		36,000 25,000 39,000 26,000 35,000 84,000 93,000 80,000 80,000 74,000 62,000 50,000 44,000 30,000 18,000 3,000 1,000  1,000 1,000 1,000 2,000 5,000 9,000 50,000 73,000 101,000 43,000 14,000 15,000 15,000 4,000 4,000 3,000 6,000 6,000 9,000 8,000 11,000 12,000 14,000 12,000 12,000 14,000 14,000 13,000 12,000 13,000 4,000 5,000 3,000 3,000 5,000 6,000 7,000 8,000 3,000 4,000 5,000 4,000 5,000 2,000 3,000 1,000  767,000 1,000 1,000 1,000 740,000 5,000 10,000 13,000 646,000 11,000 18,000 62,000 529,000 36,000 43,000 27,000           
      change in fair value of derivatives
    		983,000    -25,000    -869,000    -769,000    229,000                                                                           
      interest expense
    		-1,988,000   -1,826,000 -1,744,000 -1,725,000 -1,494,000 -1,269,000 -1,052,000 -847,000 -835,000 -650,000 -460,000 -308,000 -269,000 -229,000 -227,000 -272,000 -111,000 -85,000 -22,000 -22,000 -22,000 -21,000 -22,000 -22,000 -22,000 -21,000 -22,000 -80,000 -87,000 -85,000 -84,000                                         -4,108,000 -18,000 -29,000 -296,000 -2,673,000 -520,000 -582,000 -326,000           
      total other income
    		-969,000   -2,896,000 -1,734,000 -1,268,750 -2,154,000 -1,080,000 -1,841,000 -639,500 -1,262,000 -111,000 -1,185,000 -1,000 -475,000 49,000 3,000 204,000 -276,000 -256,000 -21,000 -20,000 -17,000 -12,000 28,000 51,000 79,000 22,000 -8,000 -65,000 -72,000 -81,000 -80,000 -9,000 6,000 6,000 9,000 8,000 11,000 12,000 14,000 12,000 12,000 14,000 14,000 3,000 -41,000 -54,000 -266,000 5,000 3,000 3,000 5,000 6,000 207,000 8,000 3,000 4,000 5,000 -136,000 -379,000 561,000 103,000 -304,000 -1,106,000 5,513,000 -119,000 -851,000 -861,000 3,161,000 1,153,000  -574,000                   
      net income
    		-5,046,000   -7,521,000 -9,631,000 -11,967,000 -11,220,000 -12,371,000 -11,489,000 -9,997,000 -10,428,000 -9,114,000 -11,527,000 -10,634,000 -8,597,000 -9,613,000 -9,932,000 -7,221,000 -8,520,000 -8,449,000 -6,338,000 -7,852,000 -5,943,000 -6,114,000 -3,556,000 -5,137,000 -2,784,000 -2,998,000 -2,375,000 -3,050,000 -2,752,000 -3,840,000 -4,258,000 -2,382,000 -4,408,000 -4,508,000 -4,937,000 -4,591,000 -4,526,000 -5,519,000 -6,800,000 -4,671,000 -5,887,000 -4,643,000 -4,826,000 -3,731,000 -3,518,000 -3,429,000 -5,110,000 -2,799,000 -3,542,000 -2,544,000 -3,203,000 -2,376,000 -2,689,000 -2,660,000 -1,950,000 -3,368,000 -2,028,000 -3,127,000 -2,392,000 -728,000 -1,109,000 -1,654,000 -2,138,000 -38,966,000 -1,369,000 -2,843,000 -2,595,000 -35,976,000 214,000 -563,000 -1,986,000 -27,036,000 -2,586,000 36,000 -5,574,000 -17,954,000 720,000 -1,184,000 -7,309,000 -21,635,000 -1,680,000 -1,698,000 -1,417,000 -14,864,000 -1,763,000 -1,405,000 -14,560,573   
      yoy
    		-47.61%   -39.20% -16.17% 19.71% 7.59% 35.74% -0.33% -5.99% 21.30% -5.19% 16.06% 47.26% 0.90% 13.78% 56.71% -8.04% 43.36% 38.19% 78.23% 52.85% 113.47% 103.94% 49.73% 68.43% 1.16% -21.93% -44.22% 28.04% -37.57% -14.82% -13.75% -48.12% -2.61% -18.32% -27.40% -1.71% -23.12% 18.87% 40.90% 25.19% 67.34% 35.40% -5.56% 33.30% -0.68% 34.79% 59.54% 17.80% 31.72% -4.36% 64.26% -29.45% 32.59% -14.93% -18.48% 362.64% 82.87% 89.06% 11.88% -98.13% -18.99% -41.82% -17.61% 8.31% -739.72% 404.97% 30.66% 33.07% -108.28% -1663.89% -64.37% 50.58% -459.17% -103.04% -23.74% -17.01% -142.86% -30.27% 415.81% 45.55% -4.71% 20.85% -90.27%       
      qoq
    		   -21.91% -19.52% 6.66% -9.30% 7.68% 14.92% -4.13% 14.42% -20.93% 8.40% 23.69% -10.57% -3.21% 37.54% -15.25% 0.84% 33.31% -19.28% 32.12% -2.80% 71.93% -30.78% 84.52% -7.14% 26.23% -22.13% 10.83% -28.33% -9.82% 78.76% -45.96% -2.22% -8.69% 7.54% 1.44% -17.99% -18.84% 45.58% -20.66% 26.79% -3.79% 29.35% 6.05% 2.60% -32.90% 82.57% -20.98% 39.23% -20.57% 34.81% -11.64% 1.09% 36.41% -42.10% 66.07% -35.15% 30.73% 228.57% -34.36% -32.95% -22.64% -94.51% 2746.31% -51.85% 9.56% -92.79% -16911.21% -138.01% -71.65% -92.65% 945.48% -7283.33% -100.65% -68.95% -2593.61% -160.81% -83.80% -66.22% 1187.80% -1.06% 19.83% -90.47% 743.11% 25.48% -90.35%    
      preferred stock dividends
    		-21,000   -63,000 26,000 -63,000 -18,000 -64,000 -8,000 -63,000 6,000 -63,000  -65,000 16,000 -64,000 16,000 -67,000 -37,000 -65,000 -2,000 -65,000 -12,000 -66,000 6,000 -65,000 -35,000 -67,000 -96,000 -299,000 -294,000 -268,000 -285,000 -405,000 -254,000 -301,000 -272,000 -275,000 -63,000 -250,000 -153,000 -239,000 -208,000 -230,000 -191,000 -180,000 -278,000 -245,000 -240,000 -254,000 -123,000 -277,000 -213,000 -274,000 -238,000 -267,000 -197,000 -293,000 -253,000 -750,000 -272,000                               
      net loss applicable to common stockholders
    		-5,067,000   -7,584,000 -9,605,000 -12,030,000 -11,238,000 -12,435,000 -11,497,000 -10,060,000 -14,041,000 -9,177,000 -11,527,000 -10,699,000 -8,581,000 -9,677,000 -9,916,000 -7,288,000 -8,557,000 -8,514,000 -6,340,000 -7,917,000 -5,955,000 -6,180,000 -3,550,000 -5,202,000 -2,819,000 -3,065,000 -9,093,000 -3,349,000 -3,046,000 -4,108,000 -4,543,000 -2,787,000 -4,662,000 -4,809,000 -5,209,000 -3,877,000 -5,636,000 -5,827,000 -7,010,000 -4,967,000 -6,152,000 -4,931,000 -5,074,000 -3,968,000 -3,853,000 -3,731,000 -5,408,000 -3,111,000 -3,723,000 -11,641,000 -3,472,000 -2,708,000 -2,985,000 -2,984,000 -2,204,000 -3,718,000 -2,339,000 -3,934,000 -2,722,000                               
      net loss per common share — basic and diluted
    		-80   -120 -150 -142.5 -180 -200 -190 -145 -240 -150 -190 -117.5 -140 -160 -170 -100 -140 -150 -110 -70 -100 -110 -60 -67.5 -50 -60 -200 -75 -70 -110 -120 -105 -130 -140 -150 -160 -190 -200 -240    -220                                               
      weighted-average common shares outstanding — basic and diluted
    		65,782,000  64,205,000 63,447,000 63,204,000  62,278,000 62,233,000 61,976,000  59,704,000 59,582,000 59,480,000  59,396,000 59,389,000 59,354,000  59,290,000 58,312,000 57,132,000  57,047,000 57,035,000 56,956,000  56,631,000 50,301,000 44,975,000  40,921,000 38,227,000 37,284,000  35,165,000 34,692,000 33,928,000  29,282,000 29,023,000 28,827,000    23,062,000                                               
      change in fair value of derivative
    		   -1,096,000  -378,500 -753,000 109,000  -192,250 -489,000 489,000  70,000 -224,000 275,000  -84,500 -166,000 -172,000                                                                        
      warrant modification
    		          -3,619,000                  -6,622,000                                                               
      preferred stock accretion
    		                                     -2,000 -56,000 -58,000 -57,000 -57,000 -57,000 -58,000 -57,000 -57,000 -57,000 -57,000 -58,000 -58,000 -58,000 -57,000 -56,000 -58,000 -58,000 -57,000 -57,000 -57,000 -58,000 -57,000 -58,000                               
      deemed dividend related to beneficial conversion feature of convertible preferred stock
    		                                     -247,750 -991,000                                                     
      loss from equity method investment in galectin sciences, llc
    		                                             -10,000 -53,000 -67,000 -270,000                                           
      net loss per common share – basic and diluted
    		                                         -172.5 -260 -210  -150 -170 -170 -270 -287.5 -220 -720 -220 -137.5 -190 -190 -170 -32.5 -30 -60 -40    -60    -60    -50                   
      weighted-average common shares outstanding – basic and diluted
    		                                          23,793,000 23,731,000   22,051,000 21,983,000 20,270,000  16,988,000 16,236,000 16,079,000  15,822,000 15,710,000 13,010,000  74,118,000 69,540,000 66,932,000    49,899,034,000    48,165,492,000    43,331,825,000    34,827,815               
      change in fair value of convertible debt instrument
    		                                                                         -2,335,000 5,000 15,000 -1,111,000               
      change in fair value of warrant liabilities
    		                                                           -140,000 -384,000 70,000 100,000 -305,000 -1,106,000 12,623,000 -122,000 -852,000 -862,000 10,298,000 1,148,000 1,301,000 -587,000 11,733,000 -1,216,000 1,804,000 -2,305,000               
      other income
    		                                                      200,000            2,000                         
      modification of warrants
    		                                                 -2,190,750  -8,763,000                                        
      series a 12% preferred stock dividend
    		                                                             -36,000 -48,000 -49,000  -291,000 -53,000 -52,000                        
      series b-1 12% preferred stock dividend
    		                                                             -42,750 -57,000 -57,000  -58,000 -59,000 -57,000                        
      series b-2 12% preferred stock dividend
    		                                                             -87,250 -134,000 -121,000  -72,000 -50,000 -15,000                        
      series b preferred stock accretion
    		                                                             -406,500 -551,000 -594,000  -401,000 -339,000 -358,000                        
      net loss applicable to common stock
    		                                                             -1,797,750 -1,899,000 -2,475,000 -2,817,000   -3,337,000 -2,859,000    -2,069,000                   
      basic and diluted net loss per share
    		                                                             -0.02 -0.03 -0.05    -0.07                        
      shares used in computing basic and diluted net loss per share
    		                                                             2,033 58,764 53,911    50,357                        
      other income and
    		                                                                                           
      series a 12% convertible preferred stock dividend
    		                                                                -47,000    -52,000 -426,000 52,000 -52,000 -83,000                   
      series b-1 12% redeemable convertible preferred stock dividend
    		                                                                -57,000    -30,000                       
      series b-2 12% redeemable convertible preferred stock dividend
    		                                                                -94,000                           
      series b redeemable convertible preferred stock accretion
    		                                                                -481,000                           
      accretion of series b-2 beneficial conversion feature
    		                                                                 -70,000 -45,000 -12,000                        
      net income applicable to common stock
    		                                                                 -2,027,750 -1,915,000   -630,500 162,000 -615,000                    
      basic and diluted net income per share
    		                                                                 -0.043 -0.04                         
      shares used in computing basic and diluted net income per share
    		                                                                 12,058 48,447                         
      series b-1 redeemable convertible preferred stock accretion
    		                                                                    -182,000                       
      other income and expense
    		                                                                                           
      net income per share
    		                                                                     -0.013  -0.01  -0.053 -0.06  -0.16 -0.07 0.03 -0.04 -0.27 -0.045 -0.06 -0.06 -0.05 -0.05 -0.07     
      weighted-average common shares outstanding—basic
    		                                                                      47,947,609 47,929,407   40,364,792 40,364,792   28,600,489 27,735,713            
      weighted-average common shares outstanding—diluted
    		                                                                      47,947,609 47,929,407   40,364,792 40,364,792   30,426,401 27,750,263            
      total other income and
    		                                                                       1,311,000  -765,000 -1,218,000 1,808,000 -3,650,000 -505,250 2,649,000 915,000            
      change in fair value of convertible debt instrument and warrant liabilities
    		                                                                             -174,750 3,133,000 1,454,000 -5,286,000           
      total other income and expense
    		                                                                                -5,585,000           
      weighted-average common shares outstanding—basic and diluted
    		                                                                                27,315,411    27,315,411       
      interest and other income
    		                                                                                 263,000 25,000 30,000 36,000 156,000 36,000 32,000 137,703   
      interest and other expenses:
    		                                                                                           
      amortization of debt discount on convertible notes
    		                                                                                        1,258,012   
      debt conversion expense
    		                                                                                        503,019   
      interest expense on convertible notes
    		                                                                                        485,377   
      other interest expense
    		                                                                                           
      total interest and other expenses
    		                                                                                        -2,246,408   
      weighted-average common shares outstanding
    		                                                                                           
      basic and diluted
    		                                                                                  27,315,411 27,315,411        
      (a) the following summarizes the allocation of the stock-based compensation charge:
    		                                                                                           
      total
    		                                                                                 4   16 910 1 40 954,180   
      weighted-average common shares outstanding - basic and diluted
    		                                                                                      26,380,628 25,227,817    
      net income per share
    		                                                                     -0.013  -0.01  -0.053 -0.06  -0.16 -0.07 0.03 -0.04 -0.27 -0.045 -0.06 -0.06 -0.05 -0.05 -0.07     
      diluted
    		                                                                                       -0.06    
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 2009-12-31 2009-09-30 2009-06-30 2009-03-31 2008-12-31 2008-09-30 2008-06-30 2008-03-31 2007-12-31 2007-09-30 2007-06-30 2007-03-31 2006-12-31 2006-09-30 2006-06-30 2006-03-31 2005-12-31 2005-09-30 2005-06-30 2005-03-31 2004-12-31 2004-09-30 2004-06-30 2004-03-31 2003-12-31 2002-12-31 
                                                                                                 
        (in thousands, except per share
      		                                                                                           
        assets
      		                                                                                           
        current assets:
      		                                                                                           
        cash and cash equivalents
      		14,111,000 17,720,000 11,525,000 13,771,000 7,431,000 15,120,000 27,060,000 25,598,000 23,555,000 25,660,000 20,362,000 17,966,000 17,799,000 18,592,000 15,831,000 24,178,000 31,606,000 39,648,000 36,600,000 31,598,000 20,760,000 27,142,000 32,556,000 40,768,000 43,328,000 47,480,000 50,337,000 52,043,000 6,972,000 8,253,000 10,136,000 10,497,000 3,988,000 3,053,000 6,958,000 9,127,000 13,644,000 15,362,000 16,059,000 18,003,000 22,356,000 25,846,000 21,319,000 26,362,000 29,349,000 29,128,000 31,201,000 34,423,000 36,594,000 10,489,000 9,715,000 5,099,000 7,018,000 9,364,000 11,059,000 13,130,000 15,314,000 6,397,000 7,944,000 7,984,000 6,948,000 5,891,000 2,814,000 2,863,000 120,000 251,000 468,000 982,000 861,000 318,000 816,000 1,554,000 3,255,000 1,319,000 1,138,000 2,380,000 4,323,000 773,000 3,125,000 4,719,000 11,894,000 4,466,000 6,002,000 7,337,000 9,078,000 10,704,000 12,454,000 8,776,000 6,543,521 7,607,818 1,921,233 
        prepaid expenses and other current assets
      		1,580,000 1,716,000 1,204,000 1,656,000 1,854,000 2,132,000 1,606,000 1,689,000 1,905,000 2,050,000 1,249,000 1,502,000 1,753,000 1,960,000 1,290,000 1,607,000 1,901,000 2,172,000 1,398,000 1,736,000 2,034,000 2,323,000 1,327,000 352,000 556,000 729,000 136,000 652,000 511,000 579,000 394,000 541,000 685,000 766,000 53,000 202,000 353,000 432,000 53,000 239,000 425,000 554,000 183,000 305,000 611,000 533,000 90,000 87,000 151,000 198,000 27,000 88,000 137,000 153,000 89,000 85,000 115,000 104,000 51,000 71,000 73,000 70,000 50,000 67,000 57,000 53,000 53,000 79,000 65,000 62,000 79,000 98,000 72,000 70,000 80,000 120,000 151,000 163,000 151,000 249,000 221,000 228,000 193,000 210,000 144,000 120,000 68,000 98,000 130,888 88,429 72,733 
        total current assets
      		15,691,000 19,436,000 12,729,000 15,427,000 9,285,000 17,252,000 28,666,000 27,287,000 25,460,000 27,710,000 21,611,000 19,468,000 19,552,000 20,552,000 17,121,000 25,785,000 33,507,000 41,820,000 37,998,000 33,334,000 22,794,000 29,465,000 33,883,000 41,120,000 43,884,000 48,209,000 50,473,000 52,695,000 7,483,000 8,832,000 10,530,000 11,038,000 4,673,000 3,819,000 7,011,000 9,329,000 13,997,000 15,794,000 16,112,000 18,242,000 22,781,000 26,400,000 21,502,000 26,667,000 29,960,000 29,661,000 31,291,000 34,510,000 36,745,000 10,687,000 9,742,000 5,187,000 7,155,000 9,517,000 11,148,000 13,215,000 15,429,000 6,501,000 7,995,000 8,055,000 7,021,000 6,195,000 2,864,000 2,930,000 177,000 304,000 521,000 1,061,000 926,000 380,000 895,000 1,652,000 3,460,000 1,389,000 1,218,000 2,500,000 4,474,000 5,936,000 8,276,000 9,968,000 12,115,000 4,694,000 6,195,000 7,547,000 9,222,000 10,824,000 12,522,000 8,874,000 6,674,409 7,696,247 1,993,966 
        other
      		68,000 96,000    243,000    490,000    733,000    7,000    135,000    258,000 287,000 317,000 347,000 174,000 86,000 172,000 258,000 342,000                                                          
        total assets
      		15,759,000 19,532,000 12,865,000 15,602,000 9,528,000 17,495,000 28,972,000 27,655,000 25,890,000 28,200,000 22,163,000 20,081,000 20,225,000 21,285,000 17,914,000 25,886,000 33,615,000 41,827,000 38,038,000 33,405,000 22,897,000 29,600,000 34,049,000 41,317,000 44,111,000 48,467,000 50,760,000 53,012,000 7,830,000 9,006,000 10,616,000 11,210,000 4,931,000 4,161,000 7,011,000 9,329,000 13,997,000 15,795,000 16,115,000 18,247,000 22,788,000 26,408,000 21,512,000 26,679,000 29,974,000 29,677,000 31,319,000 34,594,000 36,899,000 10,713,000 9,777,000 5,225,000 7,196,000 9,561,000 11,193,000 13,322,000 15,538,000 6,612,000 8,103,000 8,160,000 7,124,000 6,300,000 2,985,000 3,054,000 305,000 436,000 815,000 1,364,000 1,239,000 704,000 1,233,000 2,017,000 3,837,000 1,782,000 1,683,000 2,980,000 4,915,000 6,363,000 8,661,000 10,287,000 12,381,000 4,963,000 6,550,000 7,888,000 9,527,000 11,110,000 12,828,000 9,169,000 6,984,714 8,001,975 2,283,167 
        liabilities, redeemable convertible preferred stock and stockholders’ equity
      		                                                                                           
        current liabilities:
      		                                                                                           
        accounts payable
      		3,121,000 3,245,000 5,390,000 5,865,000 6,534,000 5,656,000 2,795,000 3,698,000 3,797,000 6,431,000 2,681,000 1,976,000 2,553,000 3,890,000 2,352,000 2,964,000 1,906,000 1,805,000 1,917,000 924,000 382,000 1,292,000 691,000 206,000 660,000 1,661,000 354,000 396,000 448,000 297,000 171,000 220,000 1,151,000 608,000 166,000 399,000 1,346,000 910,000 652,000 932,000 1,311,000 448,000 929,000 775,000 922,000 906,000 838,000 665,000 486,000 762,000 377,000 285,000 316,000 397,000 256,000 246,000 669,000 384,000 198,000 129,000 182,000 125,000 189,000 101,000 170,000 221,000 496,000 757,000 805,000 447,000 160,000 238,000 463,000 601,000 573,000 428,000 584,000 340,000 416,000 244,000 518,000 295,000 163,000 246,000 369,000 206,000 340,000 96,000 636,133 143,749 302,899 
        accrued expenses
      		4,186,000 4,722,000    8,204,000    9,182,000    9,058,000    7,163,000    4,042,000    1,093,000    1,512,000 1,475,000 1,148,000 1,132,000 2,292,000 4,175,000 3,045,000 3,016,000 2,802,000 3,435,000 2,636,000 1,939,000 845,000 797,000 1,065,000 369,000 729,000 542,000 1,413,000 1,451,000 1,651,000 1,226,000 1,129,000 1,152,000 1,161,000 1,186,000 1,254,000 1,266,000 1,551,000 417,000 376,000 182,000 537,000 582,000 708,000 716,000 779,000 571,000 444,000 379,000 380,000 244,000 364,000 438,000 362,000 463,000 538,000 537,000 512,000 681,000 639,000 633,000      267,000    174,644 
        accrued dividends payable
      		 63,000  63,000  63,000  63,000  63,000  64,000  64,000  64,000  65,000  65,000  65,000  66,000  66,000  66,000  299,000  67,000  68,000  68,000  68,000  68,000  67,000  68,000  68,000  69,000  73,000  79,000  80,000  80,000  80,000  81,000  48,000  227,000  52,000  154,000 134,000 52,000 104,000 52,000 83,000                   
        total current liabilities
      		7,307,000 8,030,000 136,445,000 10,774,000 110,840,000 35,409,000 25,258,000 14,617,000 12,633,000 15,676,000 10,522,000 9,953,000 11,533,000 13,012,000 9,588,000 10,892,000 9,535,000 9,033,000 8,299,000 6,054,000 4,663,000 5,399,000 2,488,000 4,275,000 1,316,000 2,820,000 1,216,000 1,319,000 907,000 2,108,000 1,646,000 1,435,000 2,283,000 2,968,000 4,341,000 3,512,000 4,362,000 3,780,000 4,087,000 3,636,000 3,250,000 1,360,000   1,291,000 1,703,000 1,380,000 2,147,000 1,937,000 2,486,000 1,603,000 1,493,000 1,468,000 1,638,000 1,442,000 1,780,000 2,135,000 2,215,000 815,000 786,000 858,000 1,771,000 771,000 1,036,000 886,000 1,052,000 1,067,000 1,355,000 1,318,000 1,079,000 708,000 674,000 984,000 2,600,000 1,311,000 1,400,000 1,716,000 5,989,000 6,347,000 7,060,000 6,060,000 1,380,000 1,224,000 883,000 823,000 1,005,000 607,000 698,000 1,132,200 377,909 666,793 
        convertible notes payable and accrued interest, net of debt discounts – related party
      		32,878,000 32,702,000    10,733,000    30,902,000    29,964,000    29,048,000 19,299,000                                                                         
        derivative liabilities
      		2,979,000 3,962,000 3,742,000  136,000 47,000 359,000 1,764,000 1,873,000 1,004,000 1,342,000 852,000 1,342,000 573,000   901,000 1,130,000 1,191,000                                                                         
        borrowing and accrued interest under convertible line of credit, net of debt discount – related party
      		102,832,000 101,033,000    74,376,000 72,942,000 62,046,000 51,324,000 40,839,000 30,474,000 29,926,000 19,741,000 9,864,000                                                                              
        total liabilities
      		145,996,000 145,727,000 136,445,000 132,769,000 121,789,000 120,565,000 121,453,000 109,802,000 96,976,000 88,441,000 73,036,000 71,208,000 62,871,000 53,479,000 40,249,000 41,109,000 39,808,000 39,211,000 28,789,000 16,289,000 4,663,000 5,407,000 2,507,000 4,306,000 1,358,000 2,872,000 1,278,000 1,391,000 988,000 2,108,000 1,646,000 1,435,000 2,283,000 2,968,000 4,341,000 3,512,000 4,362,000 3,780,000 4,087,000 3,636,000 3,250,000 1,360,000 1,726,000 1,908,000 1,291,000 1,703,000 1,380,000 2,147,000 1,937,000 2,486,000 1,604,000 1,498,000 1,473,000 1,644,000 1,442,000 1,780,000 2,135,000 2,215,000 815,000 789,000 865,000 1,783,000 2,227,000 2,944,000 3,646,000 2,989,000 3,508,000 3,717,000 2,883,000 1,173,000 1,616,000 2,730,000 7,001,000 4,706,000 3,435,000 2,305,000 4,421,000 6,385,000 8,646,000             
        commitments and contingencies
      		                                                                                           
        series c 6% super dividend redeemable convertible preferred stock; 1,000 shares authorized, 176 issued and outstanding at march 31, 2026 and december 31, 2025, redemption value: 7,966,000, liquidation value: 1,760,000 at march 31, 2026
      		1,723,000                                                                                           
        stockholders’ equity
      		                                                                                           
        undesignated stock, 0.01 par value...
      		                                                                                           
        series a 12% convertible preferred stock; 1,742,500 shares authorized, 1,185,000 and 1,210,000 issued and outstanding at march 31, 2026 and december 31, 2025, respectively, liquidation value 1,210,000 at march 31, 2026
      		480,000                                                                                           
        common stock, 0.001 par value...
      		65,000 65,000 64,000 63,000 63,000 62,000 62,000 62,000 61,000 61,000 61,000 59,000 59,000 59,000 59,000 59,000 59,000 59,000 59,000 59,000 56,000 56,000 56,000 56,000 56,000 56,000 56,000 56,000 45,000 41,000 41,000 41,000 38,000 36,000 36,000 35,000 35,000 33,000 29,000 29,000 28,000 28,000 23,000 23,000 23,000 22,000 22,000 22,000 22,000 18,000 18,000 16,000 16,000 16,000 16,000 16,000 16,000 13,000 77,000 74,000 69,000 64,000 61,000 58,000 52,000 52,000 51,000 50,000 50,000 48,000 48,000 49,000 48,000 40,000 40,000 40,000 40,000 32,000 29,000 28,000 27,000 27,000 27,000 27,000 27,000 27,000 27,000 25,000 24,079 24,079 19,034 
        additional paid-in capital
      		305,108,000 304,073,000 301,127,000 299,318,000 296,630,000 296,217,000 294,776,000 293,872,000 292,499,000 291,847,000 291,145,000 276,852,000 276,156,000 275,081,000 274,241,000 272,772,000 272,108,000 271,001,000 270,347,000 269,657,000 262,264,000 261,883,000 261,316,000 260,820,000 260,382,000 259,673,000 258,357,000 257,678,000 209,845,000 194,130,000 192,843,000 190,602,000 179,359,000 173,363,000 172,053,000 170,539,000 169,548,000 166,721,000 162,176,000 159,788,000 158,947,000 157,504,000 147,338,000 146,217,000 145,256,000 139,531,000 137,518,000 136,239,000 135,030,000 102,841,000 99,500,000 91,394,000 81,806,000 80,535,000 79,719,000 78,583,000 77,517,000 66,367,000 65,533,000 63,289,000 58,293,000 54,022,000 51,373,000 49,370,000 44,044,000 42,532,000 41,591,000 40,402,000 38,298,000 37,329,000 36,547,000 36,243,000 33,230,000 32,196,000 32,059,000 31,900,000 31,755,000 25,673,000 34,189,000 32,864,000 30,117,000 29,986,000 29,980,000 29,980,000 29,980,000 29,965,000 29,924,000 24,416,000 20,432,547 20,376,051 9,635,531 
        accumulated deficit
      		 -432,546,000    -401,572,000    -354,372,000 -344,312,000 -330,271,000  -309,567,000    -270,694,000    -239,996,000                         -114,890,000 -111,104,000                                            
        total stockholders’ deficit
      		 -127,918,000  -118,890,000  -104,793,000    -61,964,000                                                -2,125,000   -140,000 -1,694,000 -2,828,000 -2,925,000 -5,782,000 -4,467,000 -4,061,000 -3,336,000 -2,103,000 -469,000 -383,000 -713,000 -3,164,000 -2,924,000 -1,752,000   -22,000              
        total liabilities, redeemable convertible preferred stock and stockholders’ deficit
      		15,759,000 19,532,000 12,865,000 15,602,000 9,528,000 17,495,000    28,200,000                                                6,612,000   7,124,000 6,300,000 2,985,000 3,054,000 305,000 436,000                          
        current portion of convertible notes payable and accrued interest, net of debt discounts – related party
      		    21,278,000 21,117,000                                                                                      
        current portion of derivative liabilities
      		    305,000 369,000                                                                                      
        series c 6% super dividend redeemable convertible preferred stock; 1,000 shares authorized, 176 issued and outstanding at december 31, 2025 and 2024, redemption value: 7,966,000, liquidation value: 1,760,000 at december 31, 2025
      		 1,723,000                                                                                          
        series a 12% convertible preferred stock; 1,742,500 shares authorized, 1,210,000 and 1,235,000 issued and outstanding at december 31, 2025 and 2024, respectively, liquidation value 1,210,000 at december 31, 2025
      		 490,000                                                                                          
        other assets
      		  136,000 175,000 243,000  306,000 368,000 430,000  552,000 613,000 673,000  793,000 101,000 108,000  40,000 71,000 103,000  166,000 197,000 227,000                                                                   
        liabilities, redeemable convertible preferred stock and stockholders’ deficit
      		                                                                                           
        accrued expenses and other
      		  5,038,000 4,846,000 6,895,000  11,586,000 10,856,000 8,836,000  7,841,000 7,913,000 8,980,000  7,236,000 7,864,000 7,629,000  6,382,000 5,065,000 4,281,000  1,797,000 4,003,000 656,000  862,000 857,000 459,000                                                               
        convertible notes payable and accrued interest, net of discounts – related party
      		  32,521,000  10,813,000  21,094,000 31,375,000 31,139,000  30,666,000 30,433,000 30,200,000    29,275,000                                                                           
        borrowing and accrued interest under convertible lines of credit, net of debt discount – related party
      		  89,754,000 88,150,000 75,828,000                                                                                       
        series c super dividend redeemable convertible preferred stock; 1,000 shares authorized, 176 shares issued and outstanding at september 30, 2025 and december 31, 2024, redemption value: 8,018,000, liquidation value: 1,760,000 at september 30, 2025
      		  1,723,000                                                                                         
        series a 12% convertible preferred stock; 1,742,500 shares authorized, 1,210,000 and 1,235,000 issued and outstanding at september 30, 2025 and december 31, 2024, respectively, liquidation value 1,210,000 at september 30, 2025
      		  490,000                                                                                         
        retained deficit
      		   -418,761,000 -411,177,000  -389,542,000 -378,304,000 -365,869,000    -321,094,000  -298,868,000 -290,287,000 -280,610,000  -263,407,000 -254,850,000 -246,336,000  -232,080,000 -226,125,000 -219,945,000 -216,394,000 -211,191,000 -208,373,000 -205,308,000 -196,215,000 -192,866,000 -189,820,000 -185,711,000 -181,168,000 -178,381,000 -173,719,000 -168,910,000 -163,701,000 -158,524,000 -152,887,000 -147,060,000 -140,049,000 -135,083,000 -128,930,000 -123,999,000 -118,925,000                                              
        series c super dividend redeemable convertible preferred stock; 1,000 shares authorized, 176 shares issued and outstanding at june 30, 2025 and december 31, 2024, redemption value: 8,018,000, liquidation value: 1,760,000 at june 30, 2025
      		   1,723,000                                                                                        
        series a 12% convertible preferred stock; 1,742,500 shares authorized, 1,210,000 and 1,235,000 issued and outstanding at june 30, 2025 and december 31, 2024, respectively, liquidation value 1,210,000 at june 30, 2025
      		   490,000                                                                                        
        series c super dividend redeemable convertible preferred stock; 1,000 shares authorized, 176 shares issued and outstanding at march 31, 2025 and december 31, 2024, redemption value: 7,939,000, liquidation value: 1,760,000 at march 31, 2025
      		    1,723,000                                                                                       
        series a 12% convertible preferred stock; 1,742,500 shares authorized, 1,235,000 issued and outstanding at march 31, 2025 and december 31, 2024, liquidation value 1,235,000 at march 31, 2025
      		    500,000                                                                                       
        total stockholders’ equity
      		    -113,984,000  -94,204,000 -83,870,000 -72,809,000  -52,596,000 -52,850,000 -44,369,000 -33,917,000 -24,058,000 -16,946,000 -7,916,000 893,000 7,526,000 15,393,000 16,511,000 22,470,000 29,819,000 35,288,000 41,030,000 43,872,000 47,759,000 49,898,000 5,119,000  7,247,000 8,052,000 925,000  947,000 4,094,000 7,912,000 10,292,000 10,305,000 7,487,000 12,472,000 18,040,000 12,835,000 17,877,000 21,847,000 21,195,000 23,217,000 25,724,000 28,266,000 1,481,000 1,300,000   1,165,000 3,057,000 4,906,000 6,824,000  823,000 915,000                675,000 494,000  15,000   3,583,000 5,326,000 7,005,000 8,704,000 10,105,000 12,221,000 8,471,000 5,852,514 7,624,066 1,616,374 
        property and equipment
      		                                             1,000 1,000 2,000 3,000 3,000 5,000 6,000 7,000 8,000 6,000 4,000 5,000 6,000 7,000 3,000 5,000 7,000 9,000 11,000 14,000 17,000 21,000 26,000                        
        other liabilities
      		        7,000 20,000 32,000 44,000 55,000 66,000 77,000 87,000 97,000     8,000 19,000 31,000 42,000 52,000 62,000 72,000 81,000                                                               
        series c 6% super dividend redeemable convertible preferred stock; 1,000 shares authorized, 176 issued and outstanding at december 31, 2024 and 2023, redemption value: 8,018,000, liquidation value: 1,760,000 at december 31, 2024
      		     1,723,000                                                                                      
        series a 12% convertible preferred stock; 1,742,500 shares authorized, 1,235,000 and 1,235,000 issued and outstanding at december 31, 2024 and 2023, respectively, liquidation value 1,235,000 at december 31, 2024
      		     500,000                                                                                      
        current portion of convertible notes payable and accrued interest, net of discounts – related party
      		      10,518,000                                                                                     
        series c super dividend redeemable convertible preferred stock; 1,000 shares authorized, 176 shares issued and outstanding at september 30, 2024 and december 31, 2023, redemption value: 8,124,000, liquidation value: 1,760,000 at september 30, 2024
      		      1,723,000                                                                                     
        series a 12% convertible preferred stock; 1,742,500 shares authorized, 1,235,000 issued and outstanding at september 30, 2024 and december 31, 2023, liquidation value 1,235,000 at september 30, 2024
      		      500,000                                                                                     
        total liabilities, redeemable convertible preferred stock and stockholders’ equity
      		      28,972,000 27,655,000 25,890,000  22,163,000 20,081,000 20,225,000 21,285,000 17,914,000 25,886,000 33,615,000 41,827,000 38,038,000 33,405,000 22,897,000 29,600,000 34,049,000 41,317,000 44,111,000 48,467,000 50,760,000 53,012,000 7,830,000  10,616,000 11,210,000 4,931,000  7,011,000 9,329,000 13,997,000 15,795,000 16,115,000 18,247,000 22,788,000 26,408,000 21,512,000 26,679,000 29,974,000 29,677,000 31,319,000 34,594,000 36,899,000 10,713,000 9,777,000   9,561,000 11,193,000 13,322,000 15,538,000  8,103,000 8,160,000                                
        series c super dividend redeemable convertible preferred stock; 1,000 shares authorized, 176 shares issued and outstanding at june 30, 2024 and december 31, 2023, redemption value: 8,124,000, liquidation value: 1,760,000 at june 30, 2024
      		       1,723,000                                                                                    
        series a 12% convertible preferred stock; 1,742,500 shares authorized, 1,235,000 issued and outstanding at june 30, 2024 and december 31, 2023, liquidation value 1,235,000 at june 30, 2024
      		       500,000                                                                                    
        series c super dividend redeemable convertible preferred stock; 1,000 shares authorized, 176 shares issued and outstanding at march 31, 2024 and december 31, 2023, redemption value: 8,098,000, liquidation value: 1,760,000 at march 31, 2024
      		        1,723,000                                                                                   
        series a 12% convertible preferred stock; 1,742,500 shares authorized, 1,235,000 issued and outstanding at march 31, 2024 and december 31, 2023, liquidation value 1,235,000 at march 31, 2024
      		        500,000                                                                                   
        series c 6% super dividend redeemable convertible preferred stock; 1,000 shares authorized, 176 issued and outstanding at december 31, 2023 and 2022, redemption value: 8,177,000, liquidation value: 1,760,000 at december 31, 2023
      		         1,723,000                                                                                  
        series a 12% convertible preferred stock; 1,742,500 shares authorized, 1,235,000 and 1,260,000 issued and outstanding at december 31, 2023 and 2022, respectively, liquidation value 1,235,000 at december 31, 2023
      		         500,000                                                                                  
        series c super dividend redeemable convertible preferred stock; 1,000 shares authorized, 176 shares issued and outstanding at september 30, 2023 and december 31, 2022, redemption value: 8,203,000, liquidation value: 1,760,000 at september 30, 2023
      		          1,723,000                                                                                 
        series a 12% convertible preferred stock; 1,742,500 shares authorized, 1,260,000 issued and outstanding at september 30, 2023 and december 31, 2022, liquidation value 1,260,000 at september 30, 2023
      		          510,000                                                                                 
        series c super dividend redeemable convertible preferred stock; 1,000 shares authorized, 176 shares issued and outstanding at june 30, 2023 and december 31, 2022, redemption value: 8,282,000, liquidation value: 1,760,000 at june 30, 2023
      		           1,723,000                                                                                
        series a 12% convertible preferred stock; 1,742,500 shares authorized, 1,260,000 issued and outstanding at june 30, 2023 and december 31, 2022, liquidation value 1,260,000 at june 30, 2023
      		           510,000                                                                                
        series c super dividend redeemable convertible preferred stock; 1,000 shares authorized, 176 shares issued and outstanding at march 31, 2023 and december 31, 2022, redemption value: 8,256,000, liquidation value: 1,760,000 at march 31, 2023
      		            1,723,000                                                                               
        series a 12% convertible preferred stock; 1,742,500 shares authorized, 1,260,000 issued and outstanding at march 31, 2023 and december 31, 2022, liquidation value 1,260,500 at march 31, 2023
      		            510,000                                                                               
        series c 6% super dividend redeemable convertible preferred stock; 1,000 shares authorized, 176 issued and outstanding at december 31, 2022 and 2021, redemption value: 8,335,000, liquidation value: 1,786,000 at december 31, 2022
      		             1,723,000                                                                              
        series a 12% convertible preferred stock; 1,742,500 shares authorized, 1,260,000 and 1,302,500 issued and outstanding at december 31, 2022 and 2021, respectively, liquidation value 1,260,000 at december 31, 2022
      		             510,000                                                                              
        convertible note payable and accrued interest, net of debt discount – related party
      		              29,734,000 29,504,000    9,643,000                                                                        
        derivative liability
      		              850,000 626,000    592,000                                                                        
        series c super dividend redeemable convertible preferred stock; 1,000 shares authorized, 176 shares issued and outstanding at september 30, 2022 and december 31, 2021, redemption value: 8,309,000, liquidation value: 1,760,000 at september 30, 2022
      		              1,723,000                                                                             
        series a 12% convertible preferred stock; 1,742,500 shares authorized, 1,260,000 and 1,302,500 issued and outstanding at september 30, 2022 and december 31, 2021, respectively; liquidation value 1,260,000 and 1,302,500 at september 30, 2022 and december 31, 2021, respectively
      		              510,000                                                                             
        series c super dividend redeemable convertible preferred stock; 1,000 shares authorized, 176 shares issued and outstanding at june 30, 2022 and december 31, 2021, redemption value: 8,388,000, liquidation value: 1,760,000 at june 30, 2022
      		               1,723,000                                                                            
        series a 12% convertible preferred stock; 1,742,500 shares authorized, 1,260,000 and 1,302,500 issued and outstanding at june 30, 2022 and december 31, 2021, respectively; liquidation value 1,260,000 and 1,302,500 at june 30, 2022 and december 31, 2021, respectively
      		               510,000                                                                            
        series c super dividend redeemable convertible preferred stock; 1,000 shares authorized, 176 shares issued and outstanding at march 31, 2022 and december 31, 2021, redemption value: 8,362,000, liquidation value: 1,760,000 at march 31, 2022
      		                1,723,000                                                                           
        series a 12% convertible preferred stock; 1,742,500 shares authorized, 1,302,500 issued and outstanding at march 31, 2022 and december 31, 2021, liquidation value 1,302,500 at march 31, 2022
      		                527,000                                                                           
        liabilities, redeemable convertible preferred stock and stockholders’ (deficit) equity
      		                                                                                           
        series c 6% super dividend redeemable convertible preferred stock; 1,000 shares authorized, 176 issued and outstanding at december 31, 2021 and 2020, redemption value: 8,441,000, liquidation value: 1,786,000 at december 31, 2021
      		                 1,723,000                                                                          
        stockholders’ equity:
      		                                                                                           
        series a 12% convertible preferred stock; 1,742,500 shares authorized, 1,302,500 issued and outstanding at december 31, 2021 and 2020, liquidation value 1,302,500 at december 31, 2021
      		                 527,000                                                                          
        series c super dividend redeemable convertible preferred stock; 1,000 shares authorized, 176 shares issued and outstanding at september 30, 2021 and december 31, 2020, redemption value: 8,414,000, liquidation value: 1,760,000 at september 30, 2021
      		                  1,723,000                                                                         
        series a 12% convertible preferred stock; 1,742,500 shares authorized, 1,302,500 issued and outstanding at september 30, 2021 and december 31, 2020, liquidation value 1,302,500 at september 30, 2021
      		                  527,000                                                                         
        series c super dividend redeemable convertible preferred stock; 1,000 shares authorized, 176 shares issued and outstanding at june 30, 2021 and december 31, 2020, redemption value: 8,494,000, liquidation value: 1,760,000 at june 30, 2021
      		                   1,723,000                                                                        
        series a 12% convertible preferred stock; 1,742,500 shares authorized, 1,302,500 issued and outstanding at june 30, 2021 and december 31, 2020, liquidation value 1,302,500 at june 30, 2021
      		                   527,000                                                                        
        series c super dividend redeemable convertible preferred stock; 1,000 shares authorized, 176 shares issued and outstanding at march 31, 2021 and december 31, 2020, redemption value: 8,467,000, liquidation value: 1,760,000 at march 31, 2021
      		                    1,723,000                                                                       
        series a 12% convertible preferred stock; 1,742,500 shares authorized, 1,302,500 issued and outstanding at march 31, 2021 and december 31, 2020, liquidation value 1,302,500 at march 31, 2021
      		                    527,000                                                                       
        series c 6% super dividend redeemable convertible preferred stock; 1,000 shares authorized, 176 issued and outstanding at december 31, 2020 and 2019, redemption value: 8,546,000, liquidation value: 1,786,000 at december 31, 2020
      		                     1,723,000                                                                      
        series a 12% convertible preferred stock; 1,742,500 shares authorized, 1,302,500 and 1,327,500 issued and outstanding at december 31, 2020 and 2019, respectively, liquidation value 1,302,500 at december 31, 2020
      		                     527,000                                                                      
        series c super dividend redeemable convertible preferred stock; 1,000 shares authorized, 176 shares issued and outstanding at september 30, 2020 and december 31, 2019, redemption value: 8,520,000, liquidation value: 1,760,000 at september 30, 2020
      		                      1,723,000                                                                     
        series a 12% convertible preferred stock; 1,742,500 shares authorized, 1,302,500 and 1,327,500 issued and outstanding at september 30, 2020 and december 31, 2019, respectively, liquidation value 1,302,500 at september 30, 2020
      		                      527,000                                                                     
        series c super dividend redeemable convertible preferred stock; 1,000 shares authorized, 176 shares issued and outstanding at june 30, 2020 and december 31, 2019, redemption value: 8,599,000, liquidation value: 1,760,000 at june 30, 2020
      		                       1,723,000                                                                    
        series a 12% convertible preferred stock; 1,742,500 shares authorized, 1,327,500 issued and outstanding at june 30, 2020 and december 31, 2019, liquidation value 1,327,500 at june 30, 2020
      		                       537,000                                                                    
        series c super dividend redeemable convertible preferred stock; 1,000 shares authorized, 176 shares issued and outstanding at march 31, 2020 and december 31, 2019, redemption value: 8,573,000, liquidation value: 1,760,000 at march 31, 2020
      		                        1,723,000                                                                   
        series a 12% convertible preferred stock; 1,742,500 shares authorized, 1,327,500 issued and outstanding at march 31, 2020 and december 31, 2019, liquidation value 1,327,500 at march 31, 2020
      		                        537,000                                                                   
        series c 6% super dividend redeemable convertible preferred stock; 1,000 shares authorized, 176 issued and outstanding at december 31, 2019 and 2018, redemption value: 8,652,000, liquidation value: 1,786,000 at december 31, 2019
      		                         1,723,000                                                                  
        series a 12% convertible preferred stock; 1,742,500 shares authorized, 1,327,500 issued and outstanding at december 31, 2019 and 2018, liquidation value 1,327,500 at december 31, 2019
      		                         537,000                                                                  
        series b-1 12% convertible preferred stock; 900,000 shares authorized, 0 and 900,000 shares issued and outstanding at december 31, 2019 and 2018
      		                                                                                           
        series b-2 12% convertible preferred stock; 2,100,000 shares authorized, 0 and 2,100,000 shares issued and outstanding at december 31, 2019 and 2018,
      		                                                                                           
        series b-3 8% convertible preferred stock; 2,508,000 shares authorized, 0 and 2,508,000 issued and outstanding at december 31, 2019 and 2018
      		                                                                                           
        series c super dividend redeemable convertible preferred stock; 1,000 shares authorized, 176 shares issued and outstanding at september 30, 2019 and december 31, 2018, redemption value: 8,678,000, liquidation value: 1,760,000 at september 30, 2019
      		                          1,723,000                                                                 
        series a 12% convertible preferred stock; 1,742,500 shares authorized, 1,327,500 issued and outstanding at september 30, 2019 and december 31, 2018, liquidation value 1,327,500 at september 30, 2019
      		                          537,000                                                                 
        series b-1 12% convertible preferred stock; 900,000 shares authorized, 0 and 900,000 issued and outstanding at september 30, 2019 and december 31, 2018
      		                                                                                           
        series b-2 12% convertible preferred stock; 2,100,000 shares authorized, 0 and 2,100,000 issued and outstanding at september 30, 2019 and december 31, 2018
      		                                                                                           
        series b-3 8% convertible preferred stock; 2,508,000 shares authorized, 0 and 2,508,000 issued and outstanding at september 30, 2019 and december 31, 2018
      		                                                                                           
        series c super dividend redeemable convertible preferred stock; 1,000 shares authorized, 176 shares issued and outstanding at june 30, 2019 and december 31, 2018, redemption value: 8,758,000, liquidation value: 1,760,000 at june 30, 2019
      		                           1,723,000                                                                
        series a 12% convertible preferred stock; 1,742,500 shares authorized, 1,327,500 issued and outstanding at june 30, 2019 and december 31, 2018, liquidation value 1,327,500 at june 30, 2019
      		                           537,000                                                                
        series b-1 12% convertible preferred stock; 900,000 shares authorized, 0 and 900,000 issued and outstanding at june 30, 2019 and december 31, 2018
      		                                                                                           
        series b-2 12% convertible preferred stock; 2,100,000 shares authorized, 0 and 2,100,000 issued and outstanding at june 30, 2019 and december 31, 2018
      		                                                                                           
        series b-3 8% convertible preferred stock; 2,508,000 shares authorized, 0 and 2,508,000 issued and outstanding at june 30, 2019 and december 31, 2018
      		                                                                                           
        series c super dividend redeemable convertible preferred stock; 1,000 shares authorized, 176 shares issued and outstanding at march 31, 2019 and december 31, 2018, redemption value: 8,731,000, liquidation value: 1,760,000 at march 31, 2019
      		                            1,723,000                                                               
        series a 12% convertible preferred stock; 1,742,500 shares authorized, 1,327,500 issued and outstanding at march 31, 2019 and december 31, 2018, liquidation value 1,327,500 at march 31, 2019
      		                            537,000                                                               
        series b-1 12% convertible preferred stock; 900,000 shares authorized, 0 and 900,000 issued and outstanding at march 31, 2019 and december 31, 2018
      		                                                                                           
        series b-2 12% convertible preferred stock; 2,100,000 shares authorized, 0 and 2,100,000 issued and outstanding at march 31, 2019 and december 31, 2018
      		                                                                                           
        series b-3 8% convertible preferred stock; 2,508,000 shares authorized, 0 and 2,508,000 issued and outstanding at march 31, 2019 and december 31, 2018
      		                                                                                           
        intangible assets
      		                                     1,000 3,000 5,000 7,000 8,000 10,000 12,000 14,000 15,000 17,000 19,000 21,000 23,000 24,000 26,000 28,000 30,000 33,000 34,000 35,000 36,000 37,000 38,000 39,000 39,000 53,000 54,000 55,000 56,000 214,000 218,000                       85,090 
        series c 6% super dividend redeemable convertible preferred stock; 1,000 shares authorized, 176 issued and outstanding at december 31, 2018 and 2017, redemption value: 8,863,000, liquidation value: 1,786,000 at december 31, 2018
      		                             1,723,000                                                              
        stockholders’ (deficit) equity:
      		                                                                                           
        series a 12% convertible preferred stock; 1,742,500 shares authorized, 1,327,500 and 1,377,500 issued and outstanding at december 31, 2018 and 2017, respectively, liquidation value 1,367,000 at december 31, 2018
      		                             537,000                                                              
        series b-1 12% convertible preferred stock; 900,000 shares authorized, issued and outstanding at december 31, 2018 and 2017, liquidation value 1,800,000 at december 31, 2018
      		                             1,761,000                                                              
        series b-2 12% convertible preferred stock; 2,100,000 shares authorized, issued and outstanding at december 31, 2018 and 2017, liquidation value 4,200,000 at december 31, 2018
      		                             3,697,000                                                              
        series b-3 8% convertible preferred stock; 2,508,000 shares authorized, 2,508,000 issued and outstanding at december 31, 2018 and 2017, liquidation value 2,508,000 at december 31, 2018
      		                             1,224,000                                                              
        total stockholders’ (deficit) equity
      		                             5,175,000    -530,000                  -3,089,000 -1,036,000                           -2,031,000 -3,595,000           
        total liabilities, redeemable convertible preferred stock and stockholders’ (deficit) equity
      		                             9,006,000    4,161,000                  5,225,000 7,196,000                                       
        series c super dividend convertible preferred stock; 1,000 shares authorized, 176 shares issued and outstanding at september 30, 2018 and december 31, 2017, redemption value: 7,956,000, liquidation value: 1,760,000 at september 30, 2018
      		                              1,723,000                                                             
        series a 12% convertible preferred stock; 1,742,500 shares authorized, 1,352,500 and 1,377,500 issued and outstanding at september 30, 2018 and december 31, 2017, respectively, liquidation value 1,352,500 at september 30, 2018
      		                              547,000                                                             
        series b-1 12% convertible preferred stock; 900,000 shares authorized, issued and outstanding at september 30, 2018 and december 31, 2017, liquidation value 1,800,000 at september 30, 2018
      		                              1,761,000                                                             
        series b-2 12% convertible preferred stock; 2,100,000 shares authorized, issued and outstanding at september 30, 2018 and december 31, 2017, liquidation value 4,200,000 at september 30, 2018
      		                              3,697,000                                                             
        series b-3 8% convertible preferred stock; 2,508,000 shares authorized, 2,508,000 issued and outstanding at september 30, 2018 and december 31, 2017, liquidation value 2,508,000 at september 30, 2018
      		                              1,224,000                                                             
        series c super dividend convertible preferred stock; 1,000 shares authorized, 176 shares issued and outstanding at june 30, 2018 and december 31, 2017, redemption value: 7,983,000, liquidation value: 1,760,000 at june 30, 2018
      		                               1,723,000                                                            
        series a 12% convertible preferred stock; 1,742,500 shares authorized, 1,352,500 and 1,377,500 issued and outstanding at june 30, 2018 and december 31, 2017, respectively, liquidation value 1,352,500 at june 30, 2018
      		                               547,000                                                            
        series b-1 12% convertible preferred stock; 900,000 shares authorized, issued and outstanding at june 30, 2018 and december 31, 2017, liquidation value 1,800,000 at june 30, 2018
      		                               1,761,000                                                            
        series b-2 12% convertible preferred stock; 2,100,000 shares authorized, issued and outstanding at june 30, 2018 and december 31, 2017, liquidation value 4,200,000 at june 30, 2018
      		                               3,697,000                                                            
        series b-3 8% convertible preferred stock; 2,508,000 shares authorized, 2,508,000 issued and outstanding at june 30, 2018 and december 31, 2017, liquidation value 2,508,000 at june 30, 2018
      		                               1,224,000                                                            
        series c super dividend convertible preferred stock; 1,000 shares authorized, 176 shares issued and outstanding at march 31, 2018 and december 31, 2017, redemption value: 7,957,000, liquidation value: 1,760,000 at march 31, 2018
      		                                1,723,000                                                           
        series a 12% convertible preferred stock; 1,742,500 shares authorized, 1,377,500 issued and outstanding at march 31, 2018 and december 31, 2017, liquidation value 1,377,500 at march 31, 2018
      		                                557,000                                                           
        series b-1 12% convertible preferred stock; 900,000 shares authorized, issued and outstanding at march 31, 2018 and december 31, 2017, liquidation value 1,800,000 at march 31, 2018
      		                                1,761,000                                                           
        series b-2 12% convertible preferred stock; 2,100,000 shares authorized, issued and outstanding at march 31, 2018 and december 31, 2017, liquidation value 4,200,000 at march 31, 2018
      		                                3,697,000                                                           
        series b-3 8% convertible preferred stock; 2,508,000 shares authorized, 2,508,000 issued and outstanding at march 31, 2018 and december 31, 2017, liquidation value 2,508,000 at march 31, 2018
      		                                1,224,000                                                           
        series c super dividend redeemable convertible preferred stock; 1,000 shares authorized, 176 issued and outstanding at december 31, 2017 and 2016, redemption value: 8,036,000, liquidation value: 1,786,000 at december 31, 2017
      		                                 1,723,000                                                          
        series a 12% convertible preferred stock; 1,742,500 shares authorized, 1,377,500 issued and outstanding at december 31, 2017 and 2016, respectively, liquidation value 1,418,000 at december 31, 2017
      		                                 557,000                                                          
        series b-1 12% convertible preferred stock; 900,000 shares authorized, issued and outstanding at december 31, 2017 and 2016, liquidation value 1,800,000 at december 31, 2017
      		                                 1,761,000                                                          
        series b-2 12% convertible preferred stock; 2,100,000 shares authorized, issued and outstanding at december 31, 2017 and 2016, liquidation value 4,200,000 at december 31, 2017
      		                                 3,697,000                                                          
        series b-3 8% convertible preferred stock; 2,508,000 shares authorized, 2,508,000 issued and outstanding at december 31, 2017 and 2016, liquidation value 2,508,000 at december 31, 2017
      		                                 1,224,000                                                          
        series c super dividend convertible preferred stock; 1,000 shares authorized, 176 shares issued and outstanding at september 30, 2017 and december 31, 2016, redemption value: 7,130,000, liquidation value: 1,760,000 at september 30, 2017
      		                                  1,723,000                                                         
        series a 12% convertible preferred stock; 1,742,500 shares authorized, 1,377,500 issued and outstanding at september 30, 2017 and december 31, 2016, liquidation value 1,377,500 at september 30, 2017
      		                                  557,000                                                         
        series b-1 12% convertible preferred stock; 900,000 shares authorized, issued and outstanding at september 30, 2017 and december 31, 2016, liquidation value 1,800,000 at september 30, 2017
      		                                  1,761,000                                                         
        series b-2 12% convertible preferred stock; 2,100,000 shares authorized, issued and outstanding at september 30, 2017 and december 31, 2016, liquidation value 4,200,000 at september 30, 2017
      		                                  3,697,000                                                         
        series b-3 8% convertible preferred stock; 2,508,000 shares authorized, 2,508,000 issued and outstanding at september 30, 2017 and december 31, 2016, liquidation value 2,508,000 at september 30, 2017
      		                                  1,224,000                                                         
        series c super dividend convertible preferred stock; 1,000 shares authorized, 176 shares issued and outstanding at june 30, 2017 and december 31, 2016, redemption value: 7,209,000, liquidation value: 1,760,000 at june 30, 2017
      		                                   1,723,000                                                        
        series a 12% convertible preferred stock; 1,742,500 shares authorized, 1,377,500 issued and outstanding at june 30, 2017 and december 31, 2016, liquidation value 1,377,500 at june 30, 2017
      		                                   557,000                                                        
        series b-1 12% convertible preferred stock; 900,000 shares authorized, issued and outstanding at june 30, 2017 and december 31, 2016, liquidation value 1,800,000 at june 30, 2017
      		                                   1,761,000                                                        
        series b-2 12% convertible preferred stock; 2,100,000 shares authorized, issued and outstanding at june 30, 2017 and december 31, 2016, liquidation value 4,200,000 at june 30, 2017
      		                                   3,697,000                                                        
        series b-3 8% convertible preferred stock; 2,508,000 shares authorized, 2,508,000 issued and outstanding at june 30, 2017 and december 31, 2016, liquidation value 2,508,000 at june 30, 2017
      		                                   1,224,000                                                        
        series c super dividend convertible preferred stock; 1,000 shares authorized, 176 shares issued and outstanding at march 31, 2017 and december 31, 2016, redemption value: 6,408,000, liquidation value: 1,760,000 at march 31, 2017
      		                                    1,723,000                                                       
        series a 12% convertible preferred stock; 5,000,000 shares authorized, 1,377,500 issued and outstanding at march 31, 2017 and december 31, 2016, liquidation value 1,377,500 at march 31, 2017
      		                                    557,000                                                       
        series b-1 12% convertible preferred stock; 900,000 shares authorized, issued and outstanding at march 31, 2017 and december 31, 2016, liquidation value 1,800,000 at march 31, 2017
      		                                    1,761,000                                                       
        series b-2 12% convertible preferred stock; 2,100,000 shares authorized, issued and outstanding at march 31, 2017 and december 31, 2016, liquidation value 4,200,000 at march 31, 2017
      		                                    3,697,000                                                       
        series b-3 8% convertible preferred stock; 6,000,000 shares authorized, 2,508,000 issued and outstanding at march 31, 2017 and december 31, 2016, liquidation value 2,508,000 at march 31, 2017
      		                                    1,224,000                                                       
        series b-1 12% redeemable convertible preferred stock; 900,000 shares authorized, issued and outstanding at december 31, 2015
      		                                                                                           
        series b-2 12% redeemable convertible preferred stock; 2,100,000 shares authorized, issued and outstanding at december 31, 2015
      		                                                                                           
        series c super dividend convertible preferred stock; 1,000 shares authorized, 176 issued and outstanding at december 31, 2016 and 2015, redemption value: 7,262,000, liquidation value: 1,786,000 at december 31, 2016
      		                                     1,723,000                                                      
        series a 12% convertible preferred stock; 5,000,000 shares authorized, 1,377,500 issued and outstanding at december 31, 2016 and 2015, respectively, liquidation value 1,418,000 at december 31, 2016
      		                                     557,000                                                      
        series b-1 12% convertible preferred stock; 900,000 shares authorized, issued and outstanding at december 31, 2016, liquidation value 1,800,000 at december 31, 2016
      		                                     1,761,000                                                      
        series b-2 12% convertible preferred stock; 2,100,000 shares authorized, issued and outstanding at december 31, 2016, liquidation value 4,200,000 at december 31, 2016
      		                                     3,697,000                                                      
        series b-3 8% convertible preferred stock; 6,000,000 shares authorized, 2,508,000 issued and outstanding at december 31, 2016, liquidation value 2,508,000 at december 31, 2016
      		                                     1,224,000                                                      
        series c super dividend convertible preferred stock; 1,000 shares authorized, 176 shares issued and outstanding at september 30, 2016 and december 31, 2015, redemption value: 6,355,000, liquidation value: 1,760,000 at september 30, 2016
      		                                      1,723,000                                                     
        series a 12% convertible preferred stock; 5,000,000 shares authorized, 1,377,500 issued and outstanding at june 30, 2016 and december 31, 2015, liquidation value 1,377,500 at september 30, 2016
      		                                      557,000                                                     
        series b-1 12% convertible preferred stock; 900,000 shares authorized, issued and outstanding at september 30, 2016, liquidation value 1,800,000 at september 30, 2016
      		                                      1,760,000                                                     
        series b-2 12% convertible preferred stock; 2,100,000 shares authorized, issued and outstanding at september 30, 2016, liquidation value 4,200,000 at september 30, 2016
      		                                      3,697,000                                                     
        series b-3 8% convertible preferred stock; 1,500,000 shares authorized, issued and outstanding at september 30, 2016, liquidation value 1,500,000 at september 30, 2016
      		                                      610,000                                                     
        series b-1 12% redeemable convertible preferred stock; 900,000 shares authorized, issued and outstanding at june 30, 2016 and december 31, 2015, redemption and liquidation value 1,800,000 at june 30, 2016
      		                                       1,756,000                                                    
        series b-2 12% redeemable convertible preferred stock; 2,100,000 shares authorized, issued and outstanding at june 30, 2016 and december 31, 2015, redemption and liquidation value 4,200,000 at june 30, 2016
      		                                       3,645,000                                                    
        series c super dividend convertible preferred stock; 1,000 shares authorized, 176 shares issued and outstanding at june 30, 2016 and december 31, 2015, redemption value: 6,434,000, liquidation value: 1,760,000 at june 30, 2016
      		                                       1,723,000                                                    
        series a 12% convertible preferred stock; 5,000,000 shares authorized, 1,377,500 issued and outstanding at june 30, 2016 and december 31, 2015, liquidation value 1,377,500 at june 30, 2016
      		                                       557,000                                                    
        series b-1 12% redeemable convertible preferred stock; 900,000 shares authorized, issued and outstanding at march 31, 2016 and december 31, 2015, redemption and liquidation value 1,800,000 at march 31, 2016
      		                                        1,752,000                                                   
        series b-2 12% redeemable convertible preferred stock; 2,100,000 shares authorized, issued and outstanding at march 31, 2016 and december 31, 2015, redemption and liquidation value 4,200,000 at march 31, 2016
      		                                        3,591,000                                                   
        series c super dividend convertible preferred stock; 1,000 shares authorized, 176 shares issued and outstanding at march 31, 2016 and december 31, 2015, redemption value: 6,408,000, liquidation value: 1,760,000 at march 31, 2016
      		                                        1,723,000                                                   
        series a 12% convertible preferred stock; 5,000,000 shares authorized, 1,377,500 issued and outstanding at march 31, 2016 and december 31, 2015, liquidation value 1,377,500 at march 31, 2016
      		                                        557,000                                                   
        series b-1 12% redeemable convertible preferred stock; 900,000 shares authorized, issued and outstanding at december 31, 2015 and 2014, redemption value and liquidation value: 1,800,000, at december 31, 2015
      		                                         1,748,000                                                  
        series b-2 12% redeemable convertible preferred stock; 2,100,000 shares authorized, issued and outstanding at december 31, 2015 and 2014, redemption value and liquidation value: 4,200,000, at december 31, 2015
      		                                         3,537,000                                                  
        series c super dividend convertible preferred stock; 1,000 shares authorized, 176 issued and outstanding at december 31, 2015 and 2014, redemption value: 6,487,000, liquidation value: 1,786,000 at december 31, 2015
      		                                         1,723,000                                                  
        series a 12% convertible preferred stock; 5,000,000 shares authorized, 1,377,500 and 1,452,500 issued and outstanding at december 31, 2015 and 2014, respectively, liquidation value 1,418,000 at december 31, 2015,
      		                                         557,000                                                  
        series b-1 12% redeemable convertible preferred stock; 900,000 shares authorized, issued and outstanding at september 30, 2015 and december 31, 2014, redemption and liquidation value 1,800,000 at september 30, 2015
      		                                          1,744,000                                                 
        series b-2 12% redeemable convertible preferred stock; 2,100,000 shares authorized, issued and outstanding at september 30, 2015 and december 31, 2014, redemption and liquidation value 4,200,000 at september 30, 2015
      		                                          3,484,000                                                 
        series c super dividend convertible preferred stock; 1,000 shares authorized, 176 shares issued and outstanding at september 30, 2015 and december 31, 2014, redemption value: 5,581,000, liquidation value: 1,760,000 at september 30, 2015
      		                                          1,723,000                                                 
        series a 12% convertible preferred stock; 5,000,000 shares authorized, 1,377,500 and 1,402,500 issued and outstanding at september 30, 2015 and december 31, 2014, respectively, liquidation value 1,377,500 at september 30, 2015
      		                                          557,000                                                 
        series b-1 12% redeemable convertible preferred stock; 900,000 shares authorized, issued and outstanding at june 30, 2015 and december 31, 2014, redemption and liquidation value 1,800,000 at june 30, 2015
      		                                           1,740,000                                                
        series b-2 12% redeemable convertible preferred stock; 2,100,000 shares authorized, issued and outstanding at june 30, 2015 and december 31, 2014, redemption and liquidation value 4,200,000 at june 30, 2015
      		                                           3,431,000                                                
        series c super dividend convertible preferred stock; 1,000 shares authorized, 176 and 176 shares issued and outstanding at june 30, 2015 and december 31, 2014, respectively, redemption value: 5,660,000, liquidation value: 1,760,000 at june 30, 2015
      		                                           1,723,000                                                
        series a 12% convertible preferred stock; 5,000,000 shares authorized, 1,402,500 issued and outstanding at june 30, 2015 and december 31, 2014, liquidation value 1,402,500 at june 30, 2015
      		                                           567,000                                                
        other long-term liabilities
      		                                                  1,000 5,000 5,000 6,000      3,000 7,000 12,000 14,000 18,000 21,000 304,000 347,000 389,000 444,000 39,000   38,000                   
        series b-1 12% redeemable convertible preferred stock; 900,000 shares authorized, issued and outstanding at march 31, 2015 and december 31, 2014, redemption and liquidation value 1,800,000 at march 31, 2015
      		                                            1,735,000                                               
        series b-2 12% redeemable convertible preferred stock; 2,100,000 shares authorized, issued and outstanding at march 31, 2015 and december 31, 2014, redemption and liquidation value 4,200,000 at march 31, 2015
      		                                            3,378,000                                               
        series c super dividend convertible preferred stock; 1,000 shares authorized, 176 and 176 shares issued and outstanding at march 31, 2015 and december 31, 2014, respectively, redemption value: 5,634,000, liquidation value: 1,760,000 at march 31, 2015
      		                                            1,723,000                                               
        series a 12% convertible preferred stock; 5,000,000 shares authorized, 1,402,500 issued and outstanding at march 31, 2015 and december 31, 2014, liquidation value 1,402,500 at march 31, 2015
      		                                            567,000                                               
        series b-1 12% redeemable convertible preferred stock; 900,000 shares authorized, issued and outstanding at december 31, 2014 and 2013, redemption value and liquidation value: 1,800,000, at december 31, 2014
      		                                             1,731,000                                              
        series b-2 12% redeemable convertible preferred stock; 2,100,000 shares authorized, issued and outstanding at december 31, 2014 and 2013, redemption value and liquidation value: 4,200,000, at december 31, 2014
      		                                             3,325,000                                              
        series c super dividend convertible preferred stock; 1,000 shares authorized, 176 and 196 issued and outstanding at december 31, 2014 and 2013, respectively, redemption value: 4,835,000, liquidation value: 1,786,000 at december 31, 2014
      		                                             1,723,000                                              
        series a 12% convertible preferred stock; 5,000,000 shares authorized, 1,402,500 and 1,452,500 issued and outstanding at december 31, 2014 and 2013, liquidation value 1,445,000 at december 31, 2014,
      		                                             567,000                                              
        equity method investment in galectin sciences, llc
      		                                              10,000 63,000 130,000                                           
        series b-1 12% redeemable convertible preferred stock; 900,000 shares authorized, issued and outstanding at september 30, 2014 and december 31, 2013, redemption and liquidation value 1,800,000 at september 30, 2014
      		                                              1,727,000                                             
        series b-2 12% redeemable convertible preferred stock; 2,100,000 shares authorized, issued and outstanding at september 30, 2014 and december 31, 2013, redemption and liquidation value 4,200,000 at september 30, 2014
      		                                              3,272,000                                             
        series c super dividend convertible preferred stock; 1,000 shares authorized, 176 and 196 shares issued and outstanding at september 30, 2014 and december 31, 2013, respectively, redemption value: 4,806,000, liquidation value: 1,760,000 at september 30, 2014
      		                                              1,723,000                                             
        series a 12% convertible preferred stock; 5,000,000 shares authorized, 1,402,500 and 1,452,500 issued and outstanding at september 30, 2014 and december 31, 2013, respectively; liquidation value 1,402,500 at september 30, 2014
      		                                              567,000                                             
        series b-1 12% redeemable convertible preferred stock; 900,000 shares authorized, issued and outstanding at june 30, 2014 and december 31, 2013, redemption and liquidation value 1,800,000 at june 30, 2014
      		                                               1,723,000                                            
        series b-2 12% redeemable convertible preferred stock; 2,100,000 shares authorized, issued and outstanding at june 30, 2014 and december 31, 2013, redemption and liquidation value 4,200,000 at june 30, 2013
      		                                               3,219,000                                            
        series c super dividend convertible preferred stock; 1,000 shares authorized, 182 and 196 shares issued and outstanding at june 30, 2014 and december 31, 2013, respectively, redemption value: 5,067,000, liquidation value: 1,847,000 at june 30, 2014
      		                                               1,781,000                                            
        series a 12% convertible preferred stock; 5,000,000 shares authorized, 1,402,500 issued and outstanding at june 30, 2014 and december 31, 2013, liquidation value 1,444,500 at june 30, 2014
      		                                               567,000                                            
        series b-1 12% redeemable convertible preferred stock; 900,000 shares authorized, issued and outstanding at march 31, 2014 and december 31, 2013, redemption and liquidation value 1,800,000 at march 31, 2014
      		                                                1,719,000                                           
        series b-2 12% redeemable convertible preferred stock; 2,100,000 shares authorized, issued and outstanding at march 31, 2014 and december 31, 2013, redemption and liquidation value 4,200,000 at march 31, 2013
      		                                                3,166,000                                           
        series c super dividend convertible preferred stock; 1,000 shares authorized, 185 and 196 shares issued and outstanding at march 31, 2014 and december 31, 2013, respectively, redemption value: 5,130,000, liquidation value: 1,850,000 at march 31, 2014
      		                                                1,811,000                                           
        series a 12% convertible preferred stock; 5,000,000 shares authorized, 1,452,500 issued and outstanding at march 31, 2014 and december 31, 2013, liquidation value 1,452,500 at march 31, 2014
      		                                                587,000                                           
        deficit accumulated during the development stage
      		                                                -107,373,000 -101,965,000 -98,850,000 -95,131,000 -83,490,000 -80,018,000 -77,310,000 -74,325,000 -71,341,000 -69,137,000 -65,419,000 -63,080,000 -59,146,000 -56,424,000 -54,906,000 -53,007,000 -50,532,000 -47,715,000 -46,407,000 -44,492,000 -41,155,000 -38,550,000 -37,682,000 -37,709,000 -37,146,000 -35,160,000 -33,851,000 -31,265,000 -31,301,000 -25,727,000 -34,203,000 -34,923,000 -33,739,000 -26,430,000 -24,681,000 -23,002,000 -21,303,000 -19,886,000 -17,728,000 -15,965,000 -14,560,573 -12,706,353 -7,833,232 
        restricted cash and security deposit
      		                                                     6,000                                      
        series b-1 12% redeemable convertible preferred stock; 900,000 shares authorized, issued and outstanding at december 31, 2013 and 2012, redemption value and liquidation value: 1,800,000, at december 31, 2013
      		                                                 1,715,000                                          
        series b-2 12% redeemable convertible preferred stock; 2,100,000 shares authorized, issued and outstanding at december 31, 2013 and 2012, redemption value and liquidation value: 4,200,000, at december 31, 2013
      		                                                 3,112,000                                          
        series c super dividend convertible preferred stock; 1,000 shares authorized, 196 and 220 issued and outstanding at december 31, 2013 and 2012, respectively, redemption value: 5,547,000, liquidation value: 1,989,400 at december 31, 2013
      		                                                 1,919,000                                          
        series a 12% convertible preferred stock; 5,000,000 shares authorized, 1,452,500 and 1,562,500 issued and outstanding at december 31, 2013 and 2012, liquidation value 1,496,000 at december 31, 2013,
      		                                                 587,000                                          
        other long term assets
      		                                                  6,000 6,000 6,000                                       
        series b-1 12% redeemable convertible preferred stock; 900,000 shares authorized, issued and outstanding at september 30, 2013 and december 31, 2012, redemption value: 1,800,000, liquidation value: 1,800,000 at september 30, 2013
      		                                                  1,710,000                                         
        series b-2 12% redeemable convertible preferred stock; 2,100,000 shares authorized, issued and outstanding at september 30, 2013 and december 31, 2012, redemption value: 4,200,000, liquidation value: 4,200,000 at september 30, 2013
      		                                                  3,058,000                                         
        series c super dividend convertible preferred stock; 1,000 shares authorized, 215 and 220 shares issued and outstanding at september 30, 2013 and december 31, 2012, respectively, redemption value: 5,013,000, liquidation value: 2,150,000 at september 30, 2013
      		                                                  2,105,000                                         
        series a 12% convertible preferred stock; 5,000,000 shares authorized, 1,562,500 issued and outstanding at september 30, 2013 and december 31, 2012
      		                                                  632,000                                         
        series b-1 12% redeemable convertible preferred stock; 900,000 shares authorized, issued and outstanding at june 30, 2013 and december 31, 2012, redemption value: 1,800,000, liquidation value: 1,800,000 at june 30, 2013
      		                                                   1,706,000                                        
        series b-2 12% redeemable convertible preferred stock; 2,100,000 shares authorized, issued and outstanding at june 30, 2013 and december 31, 2012, redemption value: 4,200,000, liquidation value: 4,200,000 at june 30, 2013
      		                                                   3,005,000                                        
        series c super dividend convertible preferred stock; 1,000 shares authorized, 215 and 220 shares issued and outstanding at june 30, 2013 and december 31, 2012, respectively, redemption value: 5,110,000, liquidation value: 2,182,000 at june 30, 2013
      		                                                   2,105,000                                        
        series a 12% convertible preferred stock; 5,000,000 shares authorized, 1,562,500 issued and outstanding at june 30, 2013 and december 31, 2012
      		                                                   632,000                                        
        series b-1 12% redeemable convertible preferred stock; 900,000 shares authorized, issued and outstanding at march 31, 2013 and december 31, 2012, redemption value: 1,800,000, liquidation value: 1,800,000 at march 31, 2013
      		                                                    1,702,000                                       
        series b-2 12% redeemable convertible preferred stock; 2,100,000 shares authorized, issued and outstanding at march 31, 2013 and december 31, 2012, redemption value: 4,200,000, liquidation value: 4,200,000 at march 31, 2013
      		                                                    2,952,000                                       
        series c super dividend convertible preferred stock; 1,000 shares authorized, 215 and 220 shares issued and outstanding at march 31, 2013 and december 31, 2012, respectively, redemption value: 5,078,000, liquidation value: 2,150,000 at march 31, 2013
      		                                                    2,105,000                                       
        series a 12% convertible preferred stock; 5,000,000 shares authorized, 1,562,500 issued and outstanding at march 31, 2013 and december 31, 2012
      		                                                    632,000                                       
        deferred income
      		                                                                                           
        series b-1 12% redeemable convertible preferred stock; 900,000 shares authorized, issued and outstanding at december 31, 2012 and 2011, redemption value and liquidation value: 1,800,000, at december 31, 2012
      		                                                     1,698,000                                      
        series b-2 12% redeemable convertible preferred stock; 2,100,000 shares authorized, issued and outstanding at december 31, 2012 and 2011, redemption value and liquidation value: 4,200,000, at december 31, 2012
      		                                                     2,900,000                                      
        series c super dividend convertible preferred stock; 1,000 shares authorized, 220 issued and outstanding at december 31, 2012 and 2011, redemption value: 5,204,000, liquidation value: 2,233,000 at december 31, 2012
      		                                                     2,154,000                                      
        series a 12% convertible preferred stock; 5,000,000 shares authorized, 1,562,500 issued and outstanding at december 31, 2012 and 2011
      		                                                     632,000                                      
        restricted cash and other long-term assets
      		                                                      6,000                                     
        series b-1 12% redeemable convertible preferred stock; 900,000 shares authorized, issued and outstanding at september 30, 2012 and december 31, 2011, redemption value: 1,800,000, liquidation value: 1,800,000 at september 30, 2012
      		                                                      1,694,000                                     
        series b-2 12% redeemable convertible preferred stock; 2,100,000 shares authorized, issued and outstanding at september 30, 2012 and december 31, 2011, redemption value: 4,200,000, liquidation value: 4,200,000 at september 30, 2012
      		                                                      2,846,000                                     
        series c super dividend convertible preferred stock; 1,000 shares authorized, 220 shares issued and outstanding at september 30, 2012 and december 31, 2011, redemption value: 4,267,000, liquidation value: 2,200,000 at september 30, 2012
      		                                                      2,154,000                                     
        series a 12% convertible preferred stock; 5,000,000 shares authorized, 1,562,500 issued and outstanding at september 30, 2012 and december 31, 2011
      		                                                      632,000                                     
        restricted cash
      		                                                       69,000 69,000 69,000 64,000 64,000 59,000 59,000 59,000 59,000 59,000 59,000 59,000 59,000 59,000 59,000 62,000 69,000 69,000 70,000 70,000 69,000 64,000 59,000              
        deferred revenue
      		                                                       200,000 200,000 200,000 200,000 200,000 200,000 200,000                              
        series b-1 12% redeemable convertible preferred stock; 900,000 shares authorized, issued and outstanding at june 30, 2012 and december 31, 2011, redemption value: 1,800,000, liquidation value: 1,800,000 at june 30, 2012
      		                                                       1,689,000                                    
        series b-2 12% redeemable convertible preferred stock; 2,100,000 shares authorized, issued and outstanding at june 30, 2012 and december 31, 2011, redemption value: 4,200,000, liquidation value: 4,200,000 at june 30, 2012
      		                                                       2,793,000                                    
        series c super dividend convertible preferred stock; 1,000 shares authorized, 220 shares issued and outstanding at june 30, 2012 and december 31, 2011, redemption value: 4,366,000, liquidation value: 2,200,000 at june 30, 2012
      		                                                       2,154,000                                    
        series a 12% convertible preferred stock; 5,000,000 shares authorized, 1,562,500 issued and outstanding at june 30, 2012 and december 31, 2011
      		                                                       632,000                                    
        series b-1 12% redeemable convertible preferred stock; 900,000 shares authorized, issued and outstanding at march 31, 2012 and december 31, 2011, redemption value: 1,800,000, liquidation value: 1,800,000 at march 31, 2012
      		                                                        1,685,000                                   
        series b-2 12% redeemable convertible preferred stock; 2,100,000 shares authorized, issued and outstanding at march 31, 2012 and december 31, 2011, redemption value: 4,200,000, liquidation value of 4,200,000 at march 31, 2012
      		                                                        2,740,000                                   
        series c super dividend convertible preferred stock; 1,000 shares authorized, 220 shares issued and outstanding at march 31, 2012 and december 31, 2011, redemption value: 4,333,000, liquidation value: 2,200,000 at march 31, 2012
      		                                                        2,154,000                                   
        series a 12% convertible preferred stock; 5,000,000 shares authorized, 1,562,500 issued and outstanding at march 31, 2012 and december 31, 2011
      		                                                        632,000                                   
        grant receivable
      		                                                             234,000                              
        warrant liabilities
      		                                                            294,000 861,000 1,442,000 1,890,000 2,739,000 1,633,000 2,094,000 1,973,000 1,121,000 55,000 868,000 2,016,000 5,979,000 2,069,000 2,088,000 872,000 2,676,000 371,000              
        series b-1 12% redeemable convertible preferred stock; 900,000 shares authorized, issued and outstanding at december 31, 2011 and 2010, redemption value and liquidation value: 1,800,000, at december 31, 2011
      		                                                         1,681,000                                  
        series b-2 12% redeemable convertible preferred stock; 2,100,000 shares authorized, issued and outstanding at december 31, 2011 and 2010, redemption value and liquidation value: 4,200,000, at december 31, 2011
      		                                                         2,687,000                                  
        series c super dividend convertible preferred stock; 1,000 shares authorized, 220 and 212 issued and outstanding at december 31, 2011 and 2010, respectively, redemption value: 4,303,000, liquidation value: 2,233,000 at december 31, 2011
      		                                                         2,154,000                                  
        stockholders’ deficit:
      		                                                                                           
        series a 12% convertible preferred stock; 5,000,000 shares authorized, 1,562,500 and 1,592,500 issued and outstanding at december 31, 2011 and 2010, respectively
      		                                                         632,000                                  
        series b-1 12% redeemable convertible preferred stock; 900,000 shares authorized, issued and outstanding at september 30, 2011 and december 31, 2010, redemption value: 1,800,000, liquidation value: 1,800,000 at september 30, 2011
      		                                                          1,677,000                                 
        series b-2 12% redeemable convertible preferred stock; 2,100,000 shares authorized at september 30, 2011 and december 31, 2010, 2,100,000 issued and outstanding at september 30, 2011 and december 31, 2010, redemption value: 4,200,000, liquidation value of 4,200,000 at september 30, 2011
      		                                                          2,634,000                                 
        series c super dividend redeemable convertible preferred stock; 1,000 shares authorized, 220 and 212 issued and outstanding at september 30, 2011 and december 31, 2010, respectively, redemption value: 4,202,000, liquidation value: 2,200,000 at september 30, 2011
      		                                                          2,154,000                                 
        series a 12% convertible preferred stock; 5,000,000 shares authorized, 1,562,500 and 1,592,500 issued and outstanding at september 30, 2011 and december 31, 2010, respectively
      		                                                          632,000                                 
        series b-1 12% redeemable convertible preferred stock; 900,000 shares authorized, issued and outstanding at june 30, 2011 and december 31, 2010, redemption value: 1,800,000, liquidation value: 1,800,000 at june 30, 2011
      		                                                           1,673,000                                
        series b-2 12% redeemable convertible preferred stock; 2,100,000 shares authorized at june 30, 2011 and december 31, 2010, 2,100,000 issued and outstanding at june 30, 2011 and december 31, 2010, redemption value: 4,200,000, liquidation value of 4,200,000 at june 30, 2011
      		                                                           2,580,000                                
        series c super dividend convertible preferred stock; 1,000 shares authorized, 225 and 212 issued and outstanding at june 30, 2011 and december 31, 2010, respectively, redemption value: 4,500,000, liquidation value: 2,250,000 at june 30, 2011
      		                                                           2,203,000                                
        series a 12% convertible preferred stock; 5,000,000 shares authorized, 1,562,500 and 1,592,500 issued and outstanding at june 30, 2011 and december 31, 2010, respectively
      		                                                           632,000                                
        series b-1 12% redeemable convertible preferred stock; 900,000 shares authorized, issued and outstanding at march 31, 2011 and december 31, 2010, redemption value: 1,800,000, liquidation value: 1,800,000 at march 31, 2011
      		                                                            1,669,000                               
        series b-2 12% redeemable convertible preferred stock; 2,100,000 shares authorized at march 31, 2011 and december 31, 2010, 2,100,000 issued and outstanding at march 31, 2011 and december 31, redemption value: 4,200,000, liquidation value of 4,200,000 at march 31, 2011
      		                                                            2,527,000                               
        series c super dividend convertible preferred stock; 1,000 shares authorized, 225 and 212 issued and outstanding at march 31, 2011 and december 31, 2010, respectively, redemption value: 4,500,000, liquidation value: 2,250,000 at march 31, 2011
      		                                                            2,203,000                               
        series a 12% convertible preferred stock; 5,000,000 shares authorized, 1,592,500 issued and outstanding at march 31, 2011 and december 31, 2010
      		                                                            644,000                               
        series b-1 12% redeemable convertible preferred stock; 900,000 shares authorized, issued and outstanding at december 31, 2010 and 2009, redemption value: 1,800,000, liquidation value: 1,800,000 at december 31, 2010
      		                                                             1,664,000                              
        series b-2 12% redeemable convertible preferred stock; 2,100,000 shares authorized at december 31, 2010 and 2009, 2,100,000 and 1,330,000 issued and outstanding at december 31, 2010 and 2009, respectively, redemption value: 4,200,000, liquidation value of 4,200,000 at december 31, 2010
      		                                                             2,474,000                              
        series c super dividend convertible preferred stock; 1,000 shares authorized, 212 issued and outstanding at december 31, 2010, redemption value: 4,240,000, liquidation value: 2,120,000 at december 31, 2010
      		                                                             2,073,000                              
        series a 12% convertible preferred stock; 5,000,000 shares authorized, 1,592,500 and 1,642,500 issued and outstanding at december 31, 2010 and 2009, respectively
      		                                                             644,000                              
        series b-1 12% redeemable convertible preferred stock; 900,000 shares authorized, 900,000 shares issued and outstanding at september 30, 2010 and december 31, 2009, redemption value: 1,800,000, liquidation value: 1,800,000 at september 30, 2010
      		                                                              1,601,000                             
        series b-2 12% redeemable convertible preferred stock; 2,100,000 shares authorized, 2,100,000 and 1,330,000 issued and outstanding at september 30, 2010 and december 31, 2009, respectively, redemption value: 4,200,000, liquidation value: 4,200,000 at september 30, 2010
      		                                                              1,985,000                             
        series a 12% convertible preferred stock; 5,000,000 shares authorized, 1,592,500 and 1,642,500 issued and outstanding at september 30, 2010 and december 31, 2009, respectively
      		                                                              644,000                             
        series b-1 12% redeemable convertible preferred stock; 900,000 shares authorized, 900,000 shares issued and outstanding at june 30, 2010 and december 31, 2009, redemption value: 1,857,000, liquidation value: 1,857,000 at june 30, 2010
      		                                                               1,537,000                            
        series b-2 12% redeemable convertible preferred stock; 2,100,000 shares authorized, 2,100,000 and 1,330,000 issued and outstanding at june 30, 2010 and december 31, 2009, respectively, redemption value: 4,321,000, liquidation value: 4,321,000 at june 30, 2010
      		                                                               1,498,000                            
        series a 12% convertible preferred stock; 5,000,000 shares authorized, 1,617,500 and 1,642,500 issued and outstanding at june 30, 2010 and december 31, 2009, respectively
      		                                                               654,000                            
        series b-1 12% redeemable convertible preferred stock; 900,000 shares authorized, 900,000 shares issued and outstanding at march 31, 2010 and december 31, 2009, redemption value: 1,800,000, liquidation value: 1,800,000 at march 31, 2010
      		                                                                1,403,000                           
        series b-2 12% redeemable convertible preferred stock; 2,100,000 shares authorized, 1,660,000 and 1,330,000 issued and outstanding at march 31, 2010 and december 31, 2009, respectively, redemption value: 3,320,000, liquidation value: 3,320,000 at march 31, 2010
      		                                                                1,038,000                           
        series a 12% convertible preferred stock; 5,000,000 shares authorized, 1,617,500 and 1,642,500 issued and outstanding at march 31, 2010 and december 31, 2009, respectively
      		                                                                654,000                           
        advances received for equity consideration
      		                                                                     200,000 200,000                     
        series b-1 12% redeemable convertible preferred stock; 900,000 shares authorized, issued and outstanding at december 31, 2009 and none at december 31, 2008, redemption value: 1,800,000, liquidation value: 1,800,000 at december 31, 2009
      		                                                                 1,270,000                          
        series b-2 12% redeemable convertible preferred stock; 2,100,000 shares authorized, 1,330,000 issued and outstanding at december 31, 2009 and none at december 31, 2008, redemption value: 2,660,000, liquidation value of 2,660,000 at december 31, 2009
      		                                                                 644,000                          
        series a 12% convertible preferred stock; 5,000,000 shares authorized, 1,642,500 and 1,742,500 issued and outstanding at december 31, 2009 and 2008, respectively
      		                                                                 664,000                          
        series b-1 12% redeemable convertible preferred stock; 900,000 shares authorized, 900,000 shares issued and outstanding at september 30, 2009 and none at december 31, 2008, redemption value: 1,800,000, liquidation value: 1,800,000 at september 30, 2009
      		                                                                  1,080,000                         
        series b-2 12% redeemable convertible preferred stock; 2,100,000 shares authorized, 1,012,500 issued and outstanding at september 30, 2009 and none at december 31, 2008, redemption value: 2,025,000, liquidation value of 2,025,000 at september 30, 2009
      		                                                                  288,000                         
        series a 12% convertible preferred stock; 5,000,000 shares authorized, 1,742,500 issued and outstanding at september 30, 2009 and december 31, 2008
      		                                                                  704,000                         
        total liabilities and stockholders’ deficit
      		                                                                  815,000 1,364,000 1,239,000 704,000 1,233,000 2,017,000 3,837,000 1,782,000 1,683,000   6,363,000              
        series b-1 12% redeemable convertible preferred stock; 900,000 shares authorized, 900,000 shares issued and outstanding at june 30, 2009 and none at december 31, 2008, redemption value: 1,800,000, liquidation value: 1,887,000 at june 30, 2009
      		                                                                   888,000                        
        series b-2 12% redeemable convertible preferred stock; 2,100,000 shares authorized, 700,000 issued and outstanding at june 30, 2009 and none at december 31, 2008, redemption value: 1,400,000, liquidation value of 1,415,000 at june 30, 2009
      		                                                                   95,000                        
        series a 12% convertible preferred stock; 5,000,000 shares authorized, 1,742,500 issued and outstanding at june 30, 2009 and december 31, 2008
      		                                                                   704,000                        
        property and equipment – net
      		                                                                    33,000  48,000 54,000 62,000  80,000 91,000 102,000  121,000 63,000            
        intangible assets – net
      		                                                                    221,000  228,000 242,000 246,000  315,000 320,000 275,000  264,000 256,000 218,000    184,000       
        series b-1 12% redeemable convertible preferred stock; 900,000 shares authorized, 900,000 shares issued and outstanding at march 31, 2009, none issued and outstanding at december 31, 2008, redemption value: 1,800,000
      		                                                                    459,000                       
        series b-2 12% redeemable convertible preferred stock; 2,100,000 shares authorized, none issued and outstanding at march 31, 2009 and december 31, 2008
      		                                                                                           
        series a 12% convertible preferred stock; 5,000,000 shares authorized, 1,742,500 issued and outstanding at march 31, 2009 and december 31, 2008
      		                                                                    704,000                       
        property and equipment—net
      		                                                                     40,000    73,000    112,000    60,000 85,000 98,000  103,000    143,933 177,160 
        intangible assets—net
      		                                                                     225,000    250,000    256,000    209,000 243,000 216,000  156,000    134,844  
        liabilities and stockholders’ deficit
      		                                                                                           
        series a 12% convertible preferred stock 5,000,000 authorized, 1,742,500 shares issued and outstanding at december 31, 2008 and 1,667,500 shares subscribed, none issued and outstanding at december 31, 2007
      		                                                                     704,000                      
        advances received from subscribers for series a 12% convertible preferred stock and related warrants
      		                                                                         1,637,000                  
        other long term liabilities
      		                                                                      40,000 40,000  37,000 36,000 33,000 29,000 25,000 22,000             
        contingencies
      		                                                                                           
        undesignated shares, 0.01 par value...
      		                                                                                           
        series a 12% convertible preferred stock; 5,000,000 shares designated, 1,742,500 issued and outstanding at september 30, 2008 and 1,667,500 shares subscribed, none issued and outstanding at december 31, 2007
      		                                                                      704,000                     
        advances received for warrant subscriptions
      		                                                                       20,000                    
        series a 12% convertible preferred stock; 5,000,000 shares designated, 1,742,500 issued and outstanding at june 30, 2008 and 1,667,500 shares subscribed, none issued and outstanding at december 31, 2007
      		                                                                       704,000                    
        deferred research and development expense
      		                                                                        133,000                   
        series a 12% convertible preferred stock; 5,000,000 shares designated, 1,742,500 issued and outstanding at march 31, 2008, and 1,667,500 shares subscribed, none issued and outstanding at december 31, 2007
      		                                                                        704,000                   
        certificate of deposit
      		                                                                             5,000,000 5,000,000 5,000,000            
        convertible debt instrument
      		                                                                          275,000 434,000 595,000 5,137,000              
        liabilities and stockholders’ equity
      		                                                                                           
        total liabilities and stockholders’ equity
      		                                                                           2,980,000 4,915,000  8,661,000  12,381,000 4,963,000 6,550,000 7,888,000 9,527,000 11,110,000 12,828,000  6,984,714 8,001,975 2,283,167 
        current portion of convertible debt instrument and warrant liabilities
      		                                                                              5,250,000 6,177,000 4,909,000           
        long term portion convertible debt instrument and warrant liabilities
      		                                                                              2,277,000             
        liabilities and stockholders’ (deficit) equity
      		                                                                                           
        long term convertible debt instrument and warrant liabilities
      		                                                                               5,258,000 9,916,000           
        total liabilities and stockholders’ (deficit) equity
      		                                                                               10,287,000            
        operating expenses:
      		                                                                                           
        research and development
      		                                                                               998,000            
        general and administrative
      		                                                                               1,101,000            
        total operating expenses
      		                                                                               -2,099,000            
        other income and expense
      		                                                                                           
        interest income
      		                                                                               43,000            
        interest expense
      		                                                                               -582,000            
        change in fair value of convertible debt instrument and warrant liabilities
      		                                                                               1,454,000            
        total other income and
      		                                                                               915,000            
        net income
      		                                                                               -1,184,000            
        net income per share
      		                                                                               -40            
        weighted-average common shares outstanding—basic
      		                                                                               27,735,713,000            
        weighted-average common shares outstanding—diluted
      		                                                                               27,750,263,000            
        property and equipment - net
      		                                                                                48,000    94,000  93,000 108,000 125,690   
        deposits and other assets
      		                                                                                  27,000 27,000 27,000 27,000 27,000 27,000 26,951 26,951 26,951 
        other accrued expenses
      		                                                                                 1,085,000 1,061,000 634,000 450,000 799,000  572,000 439,421 211,854  
        deferred compensation
      		                                                                                     -1,000 -2,000 -5,000 -43,539 -69,711 -54,959 
        accounts payable - related party
      		                                                                                   3,000 4,000   11,000 50,546   
        accounts payable—related party
      		                                                                                         22,306  
        intangible assets - net
      		                                                                                      186,000 160,000 157,664   
        accrued expenses - related party
      		                                                                                       19,000 6,100   
        stockholders' equity:
      		                                                                                           
        total liabilities and stockholders' equity
      		                                                                                       9,169,000    
        accrued expenses—related party
      		                                                                                           
        offering costs payable
      		                                                                                          174,250 
        stock subscriptions receivable
      		                                                                                          -150,000 
        deferred offering costs
      		                                                                                           
        convertible notes payable
      		                                                                                          15,000 
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 2009-12-31 2009-09-30 2009-06-30 2009-03-31 2008-12-31 2008-09-30 2008-06-30 2008-03-31 2007-12-31 2007-09-30 2007-06-30 2007-03-31 2006-12-31 2006-09-30 2006-06-30 2006-03-31 2005-12-31 2005-09-30 2005-06-30 2005-03-31 2004-12-31 2004-09-30 2004-06-30 2004-03-31 
                                                                                                
          cash flows from operating activities:
        		                                                                                        
          net loss
        		                                    -4,591,000 -4,526,000 -5,519,000 -6,800,000 -4,671,000 -5,887,000 -4,643,000 -4,826,000 -3,731,000 -3,518,000 -3,429,000 -5,110,000 -2,799,000 -75,534,000 -2,544,000 -3,203,000 -64,693,000 -2,689,000 -2,660,000 -1,950,000 -54,770,000 -2,028,000 48,275,000 -53,794,000 -728,000 -1,109,000 -47,427,000 -2,138,000 -655,000 -1,369,000 -2,843,000 -2,595,000 -35,976,000 35,374,000 -35,723,000 -1,986,000 -1,309,000  36,000 -31,301,000 8,476,000 720,000 -1,184,000 -33,739,000 -1,749,000 -1,679,000 -1,699,000 -21,303,000 -2,158,000 -1,763,000 -14,110,780 -1,854,220 
          adjustments to reconcile net loss to net cash from operating activities:
        		                                                                                        
          amortization of right to use asset
        		                                                                                        
          stock-based compensation expense
        		195,000 496,000 500,000 468,000 590,000 515,000 738,000 604,000 497,000 586,000 516,000 662,000 681,000 681,000 647,000 858,000 654,000 587,000 581,000 254,000 567,000 408,000 394,000 430,000 414,000 414,000 443,000 412,000 1,152,000 663,000 1,443,000 1,187,000 272,000 230,000 269,000 330,000 478,000 376,000 402,000 1,223,000 873,000 793,000 799,000 935,000 799,000 877,000 746,000 1,648,000 513,000 14,183,000 615,000 852,000 10,204,000 818,000 879,000 473,000 6,894,000 649,000 -5,009,000 7,048,000 367,000 404,000 5,263,000 303,000 242,000 330,000 832,000 206,000 2,235,000 -1,940,000 2,409,000 81,000 137,000 159,000 145,000 1,647,000 110,000 80,000 94,000 1,188,000 7,000 0 0 1,050,000 39,000 1,000 911,332 82,668 
          non-cash interest expense
        		183,000 215,000 349,000 347,000 352,000 291,000 249,000 208,000 192,000 192,000 169,000 144,000 134,000 118,000 78,000 80,000 272,000 110,000 85,000 22,000 23,000 21,000 21,000 22,000 22,000 22,000 21,000 22,000 80,000 87,000 85,000 84,000                 0           4,279,000 0 0           5,000 13,000 19,000 4,242,000 344,000 520,000 582,000 2,500,000         
          change in fair value of derivatives
        		                                                                                        
          changes in operating assets and liabilities:
        		                                                                                        
          prepaid expenses and other assets
        		-479,000 467,000 211,000 217,000 -526,000 83,000 216,000 145,000 -801,000 253,000 275,000 183,000 -671,000 318,000 294,000 160,000 -860,000 338,000 298,000 289,000 -996,000 -975,000 204,000 173,000 -595,000 516,000 -140,000 -137,000 -353,000 146,000 145,000 81,000 -371,000 149,000 151,000 79,000 -379,000 186,000 186,000 129,000 -371,000 122,000 306,000 -78,000 -443,000 -3,000 64,000 47,000 -165,000 -95,000 49,000 16,000 -224,000                                    
          accrued interest on convertible notes payable and convertible line of credit – related party
        		                                                                                        
          accounts payable, accrued expenses and other liabilities
        		  -2,717,000 -522,000 -521,000 -173,000 1,913,000 -3,293,000 5,077,000 621,000 -1,655,000 -1,372,000 3,345,000 -1,248,000 1,283,000 864,000 669,000 2,310,000 1,326,000 -619,000                                                                     
          net cash from operating activities
        		  -6,602,000 -7,689,000 -12,791,000 -8,538,000 -8,333,000 -12,105,000 -4,702,000 -7,637,000 -9,833,000 -10,793,000    -8,042,000    -6,382,000 -5,414,000 -8,212,000 -2,604,000 -4,371,000 -3,759,000 -1,475,000 -2,330,000 -3,284,000   -3,079,000 -3,516,000  -3,123,000 -5,002,000 -3,863,000 -4,865,000 -3,444,000 -4,610,000 -3,490,000 -4,601,000 -5,084,000 -2,987,000 -4,311,000 -3,113,000 -3,282,000 -2,412,000 -3,619,000 -1,646,000 -60,036,000 -1,932,000 -2,423,000 -52,804,000 -2,079,000 -2,184,000 -1,486,000 -46,919,000 -1,251,000 43,861,000 -46,744,000 -583,000 -827,000 -43,206,000 -761,000 -822,000 -1,107,000 -1,201,000 -757,000 -34,225,000 32,780,000 -35,444,000 -1,499,000 -1,269,000 -1,074,000 -1,721,000 -29,659,000 -1,281,000 -1,513,000 -2,107,000 -23,339,000 -1,546,000 -1,302,000 -1,688,000 -16,947,000 -1,747,000 -1,804,000 -10,768,023 -1,036,977 
          capital expenditures
        		  0 0 0 0 0 0 0 0 0 0    0    0 0 0 0 0 0 0 0 0   0 0  0 0 0 0 0 0 0 0 0 0 0 0 0 0  0 0 0 0 -429,000 0 0 0 -421,000 0 0 -421,000 0 0 0  0 0 0  -419,000 417,000 0  0 0 0 -416,000 -2,000 -68,000 -25,000 -319,000 -1,000 0 -17,000 -298,000 -23,000 0 0  
          free cash flows
        		  -6,602,000 -7,689,000 -12,791,000 -8,538,000 -8,333,000 -12,105,000 -4,702,000 -7,637,000 -9,833,000 -10,793,000    -8,042,000    -6,382,000 -5,414,000 -8,212,000 -2,604,000 -4,371,000 -3,759,000 -1,475,000 -2,330,000 -3,284,000   -3,079,000 -3,516,000  -3,123,000 -5,002,000 -3,863,000 -4,865,000 -3,444,000 -4,610,000 -3,490,000 -4,601,000 -5,084,000 -2,987,000 -4,311,000 -3,113,000 -3,282,000 -2,412,000  -1,646,000 -60,036,000 -1,932,000 -2,423,000 -53,233,000 -2,079,000 -2,184,000 -1,486,000 -47,340,000 -1,251,000 43,861,000 -47,165,000 -583,000 -827,000 -43,206,000  -822,000 -1,107,000 -1,201,000  -34,644,000 33,197,000 -35,444,000  -1,269,000 -1,074,000 -1,721,000 -30,075,000 -1,283,000 -1,581,000 -2,132,000 -23,658,000 -1,547,000 -1,302,000 -1,705,000 -17,245,000 -1,770,000 -1,804,000 -10,768,023  
          cash flows from investing activities:
        		                                                                                        
          net cash from investing activities
        		                                            0 0 0 -400,000 0    -843,000    -889,000   -884,000 0 0       -890,000 898,000 -893,000 1,000 34,000 -1,000 -55,000 -871,000 -71,000 -81,000 -5,068,000 -620,000 10,000 -33,000 -53,000 -528,000 -6,000 -30,000 -429,680 -27,320 
          cash flows from financing activities:
        		                                                                                        
          net proceeds from convertible line of credit – related party
        		10,000,000 0   0 10,000,000 10,000,000 10,000,000 10,000,000 0 10,000,000 10,000,000                                                                             
          net proceeds from issuance of common stock
        		1,164,000 853,000                0                                                                       
          net proceeds from exercise of common stock options and warrants
        		1,073,000 443,000                                                            778,000                           
          net cash from financing activities
        		                              9,588,000 4,451,000 -1,000 954,000 485,000 2,145,000 4,168,000 1,500,000   9,128,000 41,000 0 4,532,000 1,040,000 60,000 241,000 30,124,000 2,420,000 74,851,000 13,000 77,000 58,349,000 0 0 10,403,000 52,152,000 1,216,000 -49,595,000 54,576,000 3,660,000 778,000 47,084,000 630,000 605,000 593,000 1,322,000 1,300,000 35,936,000 -35,735,000 35,955,000 3,434,000 1,416,000 -167,000 -167,000 34,853,000 -1,000,000 0 0 35,853,000 0 0 0 26,553,000 3,000 5,512,000   
          net increase in cash and cash equivalents
        		            2,761,000 -8,347,000   3,048,000 5,002,000       -2,857,000 -1,706,000 45,071,000 -1,281,000  -361,000 6,509,000 935,000  -2,169,000 -4,517,000 -1,718,000    -3,490,000 4,527,000 -5,043,000 -2,987,000 221,000 -2,073,000 -3,222,000 -2,171,000 26,105,000 774,000 13,980,000 -1,919,000 -2,346,000 4,702,000 -2,071,000 -2,184,000 8,917,000 4,344,000 -40,000 -4,855,000 6,948,000 3,077,000 -49,000 2,994,000 -131,000 -217,000 -514,000 121,000 543,000 821,000 -2,057,000 -382,000 1,936,000 181,000 -1,242,000 -1,943,000 4,323,000 -2,352,000 -1,594,000 -7,175,000 11,894,000 -1,536,000 -1,335,000 -1,741,000 9,078,000 -1,750,000 3,678,000 9,840,297 -1,064,297 
          cash and cash equivalents, beginning of period
        		0 0 0 15,120,000 0 0 0 25,660,000 0 0 0 18,592,000 0 0 0 39,648,000 0 0 0 27,142,000 0 0 0 47,480,000 0 0 0 8,253,000 0 0 0 3,053,000 0 0 0 15,362,000 0 0 0 25,846,000 0 0 0 29,128,000 0 0 0 10,489,000   0 9,364,000  0 0 6,397,000  0      251,000 0 0 0 318,000    1,319,000                7,607,818 
          cash and cash equivalents, end of period
        		6,195,000 -2,246,000 6,340,000 7,431,000 -11,940,000 1,462,000 2,043,000 23,555,000 5,298,000 2,396,000 -33,000 17,999,000 2,761,000 -8,347,000 -7,428,000 31,606,000 3,048,000 5,002,000 10,838,000 20,760,000 -5,414,000 -8,212,000 -2,560,000 43,328,000 -2,857,000 -1,706,000 45,071,000 6,972,000 -1,883,000 -361,000 6,509,000 3,988,000 -3,905,000 -2,169,000 -4,517,000 13,644,000 -697,000 -1,944,000 -4,353,000 22,356,000 4,527,000 -5,043,000 -2,987,000 29,349,000 -2,073,000 -3,222,000 -2,171,000 36,594,000 774,000 4,616,000 -1,919,000 7,018,000 -1,695,000 -2,071,000 -2,184,000 15,314,000 -1,547,000 -40,000 1,036,000 6,948,000 3,077,000 -49,000 2,743,000 120,000 -217,000 -514,000 121,000 861,000 -498,000 -738,000 -1,701,000 3,255,000 181,000 -1,242,000 -1,943,000 4,323,000 -2,352,000 -1,594,000 -7,175,000 11,894,000 -1,536,000 -1,335,000 -1,741,000 9,078,000 -1,750,000 3,678,000 2,232,479 6,543,521 
          noncash financing activities:
        		                                                                                        
          payment of preferred stock dividends in common stock
        		62,000 14,000 0 62,000 1,000 18,000 0 72,000 63,000 -5,000 0 62,000 65,000 -17,000 0 49,000 67,000 37,000 0 67,000 0 77,000 0 60,000 0    0 362,000 200,000 353,000 338,000 321,000 234,000 339,000 207,000 131,000 183,000 220,000 239,000 208,000 161,000 260,000 177,000 278,000 176,000 312,000 173,000 4,359,000 197,000 293,000 3,373,000 318,000 187,000 277,000 1,858,000 299,000 -989,000 2,011,000                             
          common stock purchase warrants issued in connection with related party line of credit
        		454,000 -22,000   0 308,000 260,000 277,000 194,000 0 180,000 297,000 161,000                                                                            
          noncash right to use lease asset
        		0 0 0 61,000         0 0 0 111,000                                                                         
          conversion of series a preferred to common stock
        		                                                                                        
          net income
        		  -7,521,000 -9,631,000  -11,220,000 -12,371,000 -11,489,000  -10,428,000 -9,114,000 -11,527,000  -8,597,000 -9,613,000 -9,932,000  -8,519,000 -8,449,000 -6,338,000  -5,943,000 -6,114,000 -3,556,000  -2,784,000 -2,998,000 -2,375,000  -2,752,000 -3,840,000 -4,258,000  -4,408,000 -4,508,000 -4,937,000                                                     
          adjustments to reconcile net income to net cash flows from operating activities:
        		                                                                                        
          amortization of right to use lease asset
        		 0 2,000 10,000  9,000 9,000 9,000  8,000 -16,000 32,000  7,000 7,000 10,000  10,000 10,000 10,000  10,000 8,000 9,000  8,000 8,000 10,000                                                             
          change in fair value of derivative liabilities
        		 2,205,000 1,096,000 25,000  754,000 -108,000 868,000  490,000 -490,000 769,000    -229,000                                                                         
          accrued interest on convertible debt - related party
        		 1,604,000 1,478,000 1,397,000  1,203,000 1,021,000 843,000  641,000 482,000 316,000    147,000                                                                         
          net cash flows from financing activities
        		 1,296,000    10,000,000 10,376,000 10,000,000  10,033,000 10,000,000 10,000,000      10,000,000    0 44,000 219,000  -231,000 47,401,000 2,003,000                                                             
          net (decrease)/increase in cash and cash equivalents
        		                                                                                        
          series c super dividend redeemable convertible preferred stock
        		                                                                                        
          balance at december 31, 2023
        		 0 0 176,000  0 0 176,000                                                                                 
          balance at september 30, 2024
        		                                                                                        
          balance at december 31, 2024
        		 0 0 176,000                                                                                     
          balance at september 30, 2025
        		                                                                                        
          net decrease in cash and cash equivalents
        		  6,340,000 -7,689,000  1,462,000 2,043,000 -2,105,000  2,396,000 167,000 -793,000    -8,042,000    -6,382,000  -8,212,000 -2,560,000 -4,152,000             -697,000 -1,944,000                                                   
          number of shares
        		                                                                                        
          balance at june 30, 2024
        		                                                                                        
          balance at june 30, 2025
        		                                                                                        
          balance at march 31, 2024
        		   176,000    176,000                                                                                 
          balance at march 31, 2025
        		   176,000                                                                                     
          reclassification of accrued bonus to additional paid in capital
        		        0 0 0 210,000 0 0 0 200,000 0 0 0 60,000                                                                     
          net proceeds from exercise of common stock warrants
        		     0                                                                                   
          warrant modification
        		                                                                                        
          balance at december 31, 2022
        		     0 0 176,000  0 0 176,000                                                                             
          balance at september 30, 2023
        		                                                                                        
          balance at june 30, 2023
        		                                                                                        
          balance at march 31, 2023
        		       176,000    176,000                                                                             
          net proceeds from exercise of common stock purchase warrants
        		                                                                                        
          proceeds from exercise of common stock purchase warrants
        		                                                                                        
          balance at december 31, 2021
        		         0 0 176,000  0 0 176,000                                                                         
          balance at september 30, 2022
        		                                                                                        
          balance at june 30, 2022
        		                                                                                        
          balance at march 31, 2022
        		           176,000    176,000                                                                         
          net proceeds from convertible notes payable – related party
        		                10,000,000                                                                        
          net proceeds from issuance of common stock and warrants
        		                    0 0 44,000 219,000   47,401,000 2,003,000 124,000 1,216,000 9,588,000 4,451,000 -1,000 954,000 485,000 2,145,000 5,668,000 0   9,128,000 41,000 0 4,532,000 1,099,000 60,000 0 28,178,000 833,000    28,690,000 0 0 10,403,000    28,690,000 0 0       25,309,000 -25,309,000 25,309,000 3,381,000 0 0 0 25,309,000 0 0 0 25,309,000 0 0 0 25,309,000 2,000 5,512,000   
          fair value of derivatives regarding related party convertible notes payable
        		                                                                                        
          change in fair value of derivative
        		             224,000    166,000                                                                       
          accrued interest on convertible notes payable - related party
        		             150,000                                                                           
          net cash flows from operating activities
        		             -8,347,000    -4,998,000                                                                       
          net proceeds from convertible note payable – related party
        		                                                                                        
          fair value of derivative related to related party convertible note payable
        		                                                                                        
          balance at december 31, 2020
        		             0 0 176,000  0 0 176,000                                                                     
          balance at september 30, 2021
        		                                                                                        
          balance at june 30, 2021
        		                                                                                        
          balance at march 31, 2021
        		               176,000    176,000                                                                     
          fair value of derivatives related to related party convertible notes payable
        		                                                                                        
          balance at december 31, 2019
        		                 0 0 176,000  0 0 176,000                                                                 
          balance at september 30, 2020
        		                                                                                        
          balance at june 30, 2020
        		                                                                                        
          balance at march 31, 2020
        		                   176,000    176,000                                                                 
          accounts payable and accrued expenses
        		                    2,835,000 -1,733,000 2,883,000 -1,449,000 1,528,000 -47,000 337,000 -821,000 163,000 278,000 -915,000 -617,000 -1,441,000 897,000 -918,000 650,000 -375,000 518,000 319,000 1,957,000 -433,000 -114,000 549,000 -344,000 250,000 -694,000 137,000 -476,000 803,000 1,816,000 -55,000 -90,000 2,319,000 -258,000   2,250,000 109,000 -788,000 632,000 88,000 -38,000 629,000 251,000 -66,000 -183,000 17,000 357,000 1,504,000 -1,279,000 782,000 -62,000 -73,000 70,000 -153,000 1,237,000 -245,000 214,000 -181,000 1,182,000 155,000 342,000 59,000 942,000 400,000 -92,000 61,709 754,291 
          payment of preferred stock dividends
        		                        0 2,000 -1,000 -395,000                                                             
          balance at december 31, 2018
        		                     0 0 176,000  0 0 176,000                                                             
          balance at september 30, 2019
        		                                                                                        
          balance at june 30, 2019
        		                                                                                        
          balance at march 31, 2019
        		                       176,000    176,000                                                             
          issuance of common stock for services
        		                            1,000 1,000 3,000 7,000 6,000 9,000 4,000 14,000                                                     
          net proceeds from issuance of common stock and exercise of warrants
        		                                                                                        
          balance at december 31, 2017
        		                         0 0 176,000                                                             
          balance at september 30, 2018
        		                                                                                        
          balance at june 30, 2018
        		                                                                                        
          balance at march 31, 2018
        		                           176,000                                                             
          depreciation and amortization
        		                                0 0 0 1,000 2,000 2,000 2,000 1,000 1,000 2,000 2,000 2,000 2,000 3,000 3,000 2,000 3,000 558,000 3,000 3,000 550,000 1,000 2,000 2,000 539,000 2,000 -534,000 539,000 1,000 3,000 529,000 4,000 7,000 9,000 10,000 11,000 449,000 -427,000 451,000 15,000 15,000 16,000 16,000 392,000 19,000 15,000 15,000 326,000 29,000 19,000 17,000 242,000 17,000 19,000 167,257 22,743 
          common stock purchase warrants issued in connection with line of credit
        		                                                                                        
          legal and accounting fees
        		                             14,000 26,000 51,000  47,000 18,000 50,000                                                     
          accrued compensation
        		                             313,000 378,000 314,000  77,000 111,000 173,000                                                     
          accrued research and development costs and other
        		                             0 -388,000 767,000  1,006,000 -100,000 2,793,000                                                     
          total
        		                             327,000 16,000 1,132,000  1,130,000 29,000 3,016,000                                                     
          adjustments to reconcile net income to net cash from operating activities:
        		                                                                                        
          net used in from operating activities
        		                                                                                        
          net proceeds from issuance of series b-3 preferred stock and warrants
        		                                                                                        
          loss from equity method investment in galectin sciences llc
        		                                            10,000 53,000 67,000 270,000                                         
          other long-term liabilities
        		                                                 2,000          7,000 -2,000 -4,000 301,000 -283,000 -43,000 -42,000 -55,000 405,000    1,000                 
          equity method investment in galectin sciences llc
        		                                            0 0 0 -400,000                                         
          purchases of property and equipment
        		                                                0    -429,000    -421,000   -421,000 0 0       -419,000 417,000     0 -416,000 -2,000 -68,000 -25,000 -319,000 -1,000 0 -17,000 -298,000 -23,000 0   
          change in restricted cash and security deposit
        		                                                                                        
          net proceeds from exercise of common stock warrants and options
        		                                                                                        
          proceeds from exercise of common stock warrants and options
        		                                             0 241,000 1,946,000  14,392,000 13,000 77,000      1,216,000 -2,669,000 7,520,000                             
          change in fair value of convertible debt instrument
        		                                                0           3,426,000 0 0           -59,000 -5,000 -15,000 3,505,000             
          change in fair value of warrant liabilities
        		                                                0        -9,546,000 0 9,686,000 -9,162,000 -70,000 -100,000 -10,482,000 1,106,000 -462,000 122,000 852,000 862,000 -10,298,000 8,867,000 -11,317,000 587,000 -19,000 1,216,000 -1,804,000 -9,409,000             
          write off of intangible assets
        		                                                0           351,000 15,000 0        -159,000    0 0 147,000  0 0 136,000    116,000     
          increase in patents costs and other assets
        		                                                0           -404,000 0 0           37,000 0 -50,000 -391,000 -10,000 -13,000 -43,000 -301,000 11,000 -33,000 -36,000 -230,000   -157,680 -27,320 
          net proceeds from issuance of series a preferred stock and related warrants
        		                                                           1,691,000                             
          net proceeds from issuance of series b-1 preferred stock and related warrants
        		                                                           1,548,000                             
          net proceeds from issuance of series b-2 preferred stock and related warrants
        		                                                           3,935,000                             
          net proceeds from issuance of series c preferred stock
        		                                                         0 -2,073,000 2,203,000                             
          net proceeds from issuance of convertible debt instruments
        		                                                0           10,621,000 0 0            0 0 10,621,000  0 0 10,621,000         
          repayment of convertible debt instruments
        		                                                0           -1,641,000 0 0            -167,000 -167,000 -1,086,000  0 0 -86,000         
          proceeds from shareholder advances
        		                                                0           9,000         9,000 171,000   0 0 0 9,000 0 0 0 9,000 0 0 0 9,000 0 0   
          supplemental disclosure – cash paid for interest
        		                                                           114,000 0 0           2,000 5,000 10,000 97,000 78,000 0 0 19,000    19,000 0 0   
          issuance of equity warrants in connection with equity offerings
        		                                                0    5,037,000 0 0 4,445,000    5,037,000 0 605,000 4,009,000 423,000 398,000 403,000 813,000 1,223,000     0 0 0 1,172,000             
          conversion of accrued expenses into common stock
        		                                                0    303,000 10,000      303,000 0 0           0 0 0 303,000     0 0 0 303,000 0 0   
          conversion and redemption of convertible notes and accrued interest into common stock
        		                                                           12,243,000                             
          conversion of extension costs related to convertible notes into common stock
        		                                                0           171,000 0 0           0 0 0 171,000         0 0   
          issuance of warrants to induce conversion of notes payable
        		                                                0           503,000 0 0           0 0 0 503,000     0 0 0 503,000 0 0   
          issuance of stock to acquire pro-pharmaceuticals-nv
        		                                                0           107,000 0 0           0 0 0 107,000     0 0 0 107,000 0 0   
          grant receivable
        		                                                         0                               
          net proceeds from issuance of series a 12% convertible preferred stock and related warrants
        		                                                            0 0        -1,637,000 1,637,000 53,000                 
          net proceeds from issuance of series b-1 12% redeemable convertible preferred stock and related warrants
        		                                                            0 0   0 0 48,000 1,500,000                     
          net proceeds from issuance of series b-2 12% redeemable convertible preferred stock and related warrants
        		                                                            0 0 3,305,000 630,000 605,000 593,000                       
          net proceeds from issuance of series c super dividend convertible preferred stock
        		                                                                                        
          supplemental disclosure—cash paid for interest
        		                                                                                        
          conversion and redemptions of convertible notes and accrued interest into common stock
        		                                                            0 0           0 0 0 12,243,000             
          change in restricted cash
        		                                                        -64,000   -59,000 0 0        77,000 -70,000 1,000                 
          cashless exercise of common stock options and warrants
        		                                                  120,000 38,000  0                                   
          cashless exercise of stock options and warrants
        		                                                                                        
          prepaid expenses and other current assets
        		                                                      30,000 -11,000 -120,000   -70,000 -20,000 17,000 -60,000 -4,000 0 26,000 -14,000 -3,000 -50,000 86,000 40,000 -135,000 10,000 40,000 31,000 -148,000 -12,000 49,000 -6,000 -191,000 -8,000 17,000 -66,000 -141,000 -53,000 31,000 -52,541 -42,459 
          cashless exercise of stock options
        		                                                       8,000    98,000 0 0 74,000 24,000 0 0 0 24,000                     
          dividends payable on preferred stock
        		                                                                  20,000 134,000 -52,000 52,000                   
          proceeds from (repayments of) shareholder advances
        		                                                            0 0   0 0 0 -200,000                     
          proceeds from issuance of common stock warrants
        		                                                             0       0                    
          payment of convertible preferred stock dividend in common stock
        		                                                                                        
          payment of series a12% convertible preferred stock dividend in common stock
        		                                                                                        
          supplemental disclosure — cash paid for interest
        		                                                                                        
          payment of series a 12% convertible preferred stock dividend in common stock
        		                                                                                        
          payment of series b 12% convertible preferred stock dividend in common stock
        		                                                                130,000                        
          accretion of series b-2 beneficial conversion feature
        		                                                                                        
          write-off of intangible assets
        		                                                                                20,000 0       
          changes in other assets and liabilities:
        		                                                                                        
          changes in long term liabilities
        		                                                                                        
          maturity of certificate of deposit
        		                                                                                        
          decrease in restricted cash
        		                                                                                        
          net proceeds from issuance of series a convertible preferred stock and warrants
        		                                                                                        
          net proceeds from issuance of convertible debt instrument
        		                                                                                        
          repayment of convertible debt instrument
        		                                                                                        
          non-cash financing activities
        		                                                                                        
          cashless exercise of employee stock options
        		                                                                        0 0 0 74,000     0 0 0 74,000 0 0   
          conversion of prepaid interest into common stock
        		                                                                                        
          payment of 12% convertible preferred dividend in common stock
        		                                                                    104,000 0                   
          other long term liabilities
        		                                                                     -37,000    3,000 4,000 29,000             
          certificate of deposit
        		                                                                                        
          maturity/(purchase) of certificate of deposit
        		                                                                                        
          increase in restricted cash
        		                                                                        0 -1,000 -5,000 -64,000             
          net proceeds form issuance of convertible debt instrument
        		                                                                                        
          advances received from stock subscriptions for series “a” convertible preferred stock and warrants
        		                                                                                        
          noncash financing activities
        		                                                                                        
          maturity (purchase) of certificate of deposit
        		                                                                                        
          purchase of property and equipment
        		                                                                                        
          changes in current assets and liabilities:
        		                                                                                        
          prepaid non-cash interest
        		                                                                                        
          purchase of certificate of deposit
        		                                                                            0 0           
          change in fair value of convertible debt instrument and warrant liabilities
        		                                                                             -3,133,000 -1,454,000 5,286,000         
          changes in long term liabilities:
        		                                                                                        
          deposits and other assets
        		                                                                               -27,000 0 0 0 -27,000 0 0   
          amortization of deferred extension costs through interest expense
        		                                                                                0 0 0 167,000 -1,000 0   
          settlement of accrued interest through issuance of common stock
        		                                                                                0 0 0 10,000 0 0   
          amortization of debt discount on convertible notes
        		                                                                                0 0 0 1,258,000 0 0   
          debt conversion expense
        		                                                                                0 0 0 503,000 0 0   
          interest expense related to issuance of warrants to purchase common stock
        		                                                                                0 0 0 236,000 0 0   
          net proceeds from issuance of convertible notes payable
        		                                                                                0 0 0 1,321,000 1,000 0   
          repayment of convertible notes payable
        		                                                                                0 0 0 -86,000 0 0   
          issuance of warrants in connection with equity offerings
        		                                                                                0 0 0 6,645,000 3,646,000 393,000   
          conversion of convertible notes and accrued interest into common stock
        		                                                                                0 0 0 1,220,000 0 0   
          conversion of extension costs related to conversion of convertible notes into common stock
        		                                                                                 0 0 171,000     
          writeoff of intangible assets
        		                                                                                     0   
          increase in patent costs and other assets
        		                                                                                        
          depreciation
        		                                                                                        
          stock based compensation expense
        		                                                                                        
          prepaid and other expenses
        		                                                                                        
          accounts payable
        		                                                                                        
          accrued expenses
        		                                                                                        
          supplemental disclosure of cash flow information – cash paid for interest
        		                                                                                        
          deferred stock compensation expense
        		                                                                                        
          conversion of convertible notes and accrued interest to common stock
        		                                                                                        
          offering costs payable
        		                                                                                        
          issuance of common stock and warrants