7Baggers
Quarterly
Annual
    Unit: USD2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-09-30 2017-06-30 2017-03-31 2016-09-30 2016-06-30 2016-03-31 2015-09-30 2015-06-30 2015-03-31 2014-09-30 2014-06-30 2014-03-31 2013-09-30 2013-06-30 2013-03-31 2012-09-30 2012-06-30 2012-03-31 2011-09-30 2011-06-30 2011-03-31 2010-09-30 2010-06-30 2010-03-31 2009-09-30 2009-06-30 2009-03-31 2008-12-31 2008-09-30 2008-06-30 2008-03-31 2007-12-31 2007-09-30 2007-06-30 2006-12-31 
      
    		                                                                  
      assets
    		                                                                  
      current assets:
    		                                                                  
      cash and cash equivalents
    		190,553,000 158,702,000 181,657,000 213,752,000 233,647,000 209,335,000 209,761,000 246,994,000 263,320,000 211,307,000 160,602,000 148,813,000 277,592,000 235,639,000 233,317,000 245,197,000 385,903,000 176,538,000 184,833,000 163,240,000 210,631,000 164,573,000 123,231,000 142,837,000 166,319,000 220,578,000 96,349,000 79,749,000 201,827,000 73,311,000 114,322,000 64,133,000 37,394,000 44,755,000 33,115,000 63,656,000 23,510,000 19,439,000 249,023,000 28,827,000 19,671,000 41,904,000 27,533,000 30,047,000 23,476,000 26,736,000 24,273,000 28,858,000 24,523,000 22,810,000 25,789,000 27,662,000 22,097,000 24,622,000 33,562,000 20,487,000 15,760,000 23,242,000 28,073,000 19,855,000 12,315,000 18,203,000 44,188,000 19,933,000 26,494,000  
      investments in marketable securities
    		73,290,000 72,296,000 68,916,000 36,194,000 16,110,000 50,727,000 29,842,000 39,206,000 16,980,000 54,319,000 106,507,000 144,782,000 77,108,000 151,202,000 177,878,000 237,299,000 171,057,000 206,530,000 232,596,000 320,029,000 298,451,000 145,017,000 215,642,000 309,903,000 347,875,000 355,078,000 341,978,000 424,403,000 362,556,000 465,641,000 448,198,000 15,109,000 189,838,000 235,087,000 179,284,000 150,494,000 142,341,000 217,070,000 112,396,000 119,940,000 65,511,000 36,092,000 44,121,000 30,448,000 50,700,000 58,015,000 81,942,000 66,914,000 83,673,000 46,718,000 57,257,000 66,112,000 35,484,000 44,444,000 47,870,000 68,784,000 84,670,000 85,806,000 93,051,000 116,400,000 132,635,000 136,355,000 117,339,000 99,475,000 99,229,000  
      accounts receivable
    		113,838,000 105,849,000 88,323,000 101,099,000 98,073,000 85,174,000 76,433,000 87,632,000 73,331,000 63,716,000 68,178,000 66,196,000 52,303,000 52,556,000 52,421,000 52,672,000 51,427,000 49,172,000 44,931,000 46,923,000 44,828,000 43,040,000 40,555,000 33,284,000 33,731,000 28,709,000 22,960,000 21,962,000 14,189,000 15,077,000 10,836,000 5,974,000 3,786,000 1,875,000 864,000                                
      inventories
    		177,928,000 154,875,000 132,412,000 118,782,000 115,338,000 81,320,000 60,759,000 59,696,000 56,936,000 51,381,000 27,004,000 23,816,000 13,272,000 20,879,000 24,324,000 26,818,000 22,072,000 24,086,000 18,801,000 19,556,000 15,767,000 12,979,000 12,831,000 14,041,000 9,154,000 10,395,000 8,167,000 8,390,000 6,311,000 7,769,000 8,070,000 7,272,000 3,948,000 3,698,000 3,251,000 194,000                               
      prepaid expenses and other current assets
    		38,457,000 46,285,000 39,491,000 34,909,000 35,306,000 35,145,000 54,444,000 49,533,000 52,689,000 52,099,000 37,406,000 40,209,000 38,264,000 37,367,000 30,960,000 34,848,000 20,081,000 24,176,000 21,730,000 29,721,000 15,600,000 18,275,000 15,690,000 20,008,000 19,578,000 20,116,000 13,592,000 16,592,000 16,151,000 14,432,000 10,607,000 6,246,000 6,023,000 10,792,000 5,198,000 3,330,000 2,662,000 3,544,000 3,578,000 2,484,000 1,762,000 951,000 1,758,000 1,692,000 1,978,000 1,753,000 3,077,000 2,658,000 2,789,000 3,038,000 3,076,000 2,304,000 2,897,000 2,081,000 2,504,000 4,305,000 2,653,000 1,984,000 2,463,000 1,990,000 1,671,000 1,076,000 1,513,000 1,245,000 1,432,000  
      total current assets
    		594,066,000 538,007,000 510,799,000 504,736,000 498,474,000 461,701,000 431,239,000 483,061,000 463,256,000 432,822,000 399,697,000 423,816,000 458,539,000 497,643,000 518,900,000 596,834,000 650,540,000 480,502,000 502,891,000 579,469,000 585,277,000 383,884,000 407,949,000 520,073,000 576,657,000 634,876,000 483,046,000 551,096,000 601,034,000 576,230,000 592,033,000 431,013,000 240,989,000 296,207,000 221,712,000 217,674,000 168,513,000 240,053,000 364,997,000 151,251,000 87,237,000 79,422,000 73,450,000 64,308,000 77,178,000 87,812,000 112,476,000 105,667,000 115,286,000 76,394,000 88,099,000 100,047,000 60,478,000 71,147,000 83,936,000 93,576,000 103,083,000 111,032,000 123,587,000 138,245,000 146,621,000 155,634,000 163,040,000 120,653,000 127,155,000  
      operating lease right-of-use assets
    		21,549,000 21,988,000 22,138,000 22,278,000 23,144,000 22,611,000 23,003,000 26,312,000 29,511,000 28,042,000 28,483,000 29,534,000 29,871,000 30,447,000 27,509,000 20,586,000 21,270,000                                                  
      property and equipment, less accumulated depreciation of 31,271 and 28,775 at september 30, 2025 and december 31, 2024, respectively
    		27,759,000                                                                  
      intangible assets, less accumulated amortization of 8,257 and 5,802 at september 30, 2025 and december 31, 2024, respectively
    		14,743,000                                                                  
      goodwill
    		197,797,000 197,797,000 197,797,000 197,797,000 197,797,000 197,797,000 197,797,000 197,797,000 197,797,000 197,797,000 197,797,000 197,797,000 197,797,000 197,797,000 197,797,000 197,797,000 197,797,000 197,797,000 197,797,000 197,797,000 197,797,000 197,797,000 197,797,000 197,797,000 197,797,000 197,797,000 197,797,000 197,797,000 197,797,000 197,797,000 197,797,000 197,797,000 197,797,000 197,797,000 197,797,000 197,797,000 197,797,000 207,564,000 11,613,000 11,613,000 11,613,000 11,613,000 11,613,000                        
      other non-current assets
    		12,897,000 13,371,000 13,998,000 13,641,000 18,678,000 17,361,000 17,657,000 18,553,000 21,130,000 19,049,000 20,172,000 19,242,000 17,872,000 18,045,000 25,188,000 24,427,000 22,077,000 21,200,000 20,538,000 19,095,000 26,453,000 25,876,000 29,414,000 28,317,000 14,351,000 12,035,000 11,265,000 6,683,000 6,099,000 5,915,000 5,592,000 4,219,000 3,009,000 2,932,000 1,788,000 1,657,000 1,484,000 982,000 924,000 892,000 508,000 515,000 546,000 442,000 442,000 442,000 442,000 442,000 442,000 714,000 267,000 267,000 267,000 267,000 267,000 267,000 267,000 267,000 267,000 504,000 267,000 267,000 267,000 267,000 267,000  
      total assets
    		868,811,000 815,303,000 789,839,000 785,033,000 786,557,000 749,484,000 721,789,000 777,880,000 764,084,000 730,093,000 700,519,000 724,167,000 759,528,000 800,589,000 826,938,000 905,140,000 956,675,000 786,892,000 810,034,000 886,520,000 900,542,000 701,451,000 738,349,000 850,207,000 882,292,000 918,033,000 764,702,000 789,951,000 838,589,000 825,889,000 870,005,000 680,779,000 938,966,000 993,381,000 918,180,000 914,006,000 862,907,000 986,692,000 403,913,000 192,616,000 125,487,000 117,994,000 112,357,000 69,106,000 82,335,000 93,216,000 118,211,000 111,598,000 120,801,000 78,867,000 90,288,000 102,551,000 63,762,000 74,886,000 88,137,000 98,892,000 108,676,000 116,375,000 128,773,000 143,165,000 151,083,000 159,532,000 167,097,000 124,833,000 131,583,000 59,645,000 
      liabilities and stockholders’ equity
    		                                                                  
      current liabilities:
    		                                                                  
      accounts payable
    		19,103,000 13,893,000 14,451,000 12,947,000 13,481,000 32,057,000 9,210,000 15,120,000 23,154,000 13,522,000 24,965,000 15,413,000 12,046,000 23,113,000 22,914,000 21,513,000 24,474,000 13,762,000 16,110,000 17,063,000 14,764,000 14,306,000 16,239,000                                       1,050,000 530,000 535,000 338,000  
      accrued expenses and other current liabilities
    		171,165,000 145,144,000 129,877,000 127,300,000 136,116,000 127,897,000 124,622,000 144,245,000 138,535,000 124,868,000 92,747,000 93,636,000 125,235,000 114,703,000 80,379,000 98,153,000 72,453,000 71,325,000 57,178,000 96,841,000 89,595,000 85,478,000 66,722,000                                            
      operating lease liabilities
    		8,662,000 8,610,000 8,562,000 8,455,000 8,541,000 8,112,000 8,270,000 8,324,000 7,765,000 7,840,000 8,005,000 8,552,000 7,536,000 7,543,000 7,255,000 7,409,000 7,175,000 7,106,000 6,764,000 6,872,000 7,368,000 8,516,000 7,503,000 7,189,000 6,356,000 2,678,000                                         
      total current liabilities
    		198,930,000 167,647,000 152,890,000 148,702,000 158,138,000 168,066,000 142,102,000 167,689,000 169,454,000 159,235,000 138,385,000 139,018,000 164,650,000 164,625,000 129,699,000 145,975,000 121,102,000 111,993,000 99,652,000 129,676,000 111,727,000 108,300,000 91,714,000 128,812,000 93,081,000 89,547,000 65,869,000 86,125,000 65,880,000 52,963,000 140,705,000 68,159,000 100,683,000 109,596,000 85,612,000 80,459,000 64,427,000 35,865,000 16,901,000 21,022,000 13,824,000 11,171,000 9,366,000 8,598,000 9,967,000 7,995,000 9,930,000 17,812,000 17,765,000 18,625,000 16,878,000 16,636,000 8,148,000 7,147,000 8,838,000 17,082,000 15,237,000 12,554,000 13,378,000 14,937,000 15,298,000 14,810,000 15,793,000 9,571,000 6,965,000  
      long-term debt
    		391,985,000 391,322,000 390,708,000 390,111,000 389,494,000 388,939,000 388,391,000 387,858,000 394,071,000 393,350,000 392,658,000 391,990,000 391,319,000 390,652,000 389,994,000 389,357,000 388,719,000 390,434,000 389,789,000 389,254,000 388,584,000                                              
      other non-current liabilities
    		5,298,000 8,647,000 8,487,000 7,097,000 13,477,000 12,949,000 12,771,000 13,282,000 8,962,000 9,045,000 9,648,000 8,939,000 8,146,000 8,207,000 7,335,000 6,801,000 6,823,000 6,535,000 6,268,000 6,379,000 4,817,000 4,511,000 4,214,000 5,296,000 4,591,000 3,987,000 3,609,000 2,853,000 3,029,000      1,816,000 1,735,000 1,061,000 555,000                             
      total liabilities
    		638,387,000 610,999,000 596,281,000 590,988,000 607,732,000 616,961,000 591,095,000 617,706,000 630,847,000 618,512,000 597,946,000 601,120,000 626,963,000 627,164,000 588,321,000 597,771,000 580,046,000 572,982,000 559,138,000 600,140,000 580,273,000 340,498,000 335,755,000 373,782,000 334,025,000 317,975,000 313,034,000 447,039,000 427,638,000 263,994,000 348,388,000                                   13,071,000 
      commitments and contingencies
    		                                                                  
      stockholders’ equity:
    		                                                                  
      common stock
    		3,017,000 3,016,000 3,016,000 2,944,000 2,942,000 2,923,000 2,922,000 2,918,000 2,890,000 2,856,000 2,820,000 2,815,000 2,813,000 2,811,000 2,809,000 2,808,000 2,805,000 2,685,000 2,680,000 2,650,000 2,626,000 2,614,000 2,607,000 2,598,000 2,591,000 2,589,000 2,347,000 1,942,000 1,941,000 1,939,000 1,929,000 1,707,000 1,485,000 1,482,000 1,478,000 1,399,000 1,308,000 1,304,000 1,241,000 1,024,000 853,000 789,000 703,000 556,000 556,000 556,000 554,000 524,000 524,000 407,000 406,000 406,000 337,000 337,000 337,000 287,000 287,000 287,000 287,000 285,000 285,000 285,000 285,000 284,000 283,000  
      common stock in treasury, at cost; 7,390 shares as of september 30, 2025
    		-71,000                                                                  
      additional paid-in capital
    		2,973,625,000 2,956,839,000 2,939,673,000 2,926,115,000 2,905,760,000 2,868,925,000 2,853,550,000 2,836,018,000 2,787,275,000 2,733,148,000 2,691,836,000 2,664,744,000 2,645,372,000 2,631,110,000 2,617,935,000 2,595,419,000 2,579,953,000 2,364,494,000 2,350,507,000 2,308,578,000 2,274,797,000 2,250,849,000 2,238,346,000 2,227,225,000 2,210,890,000 2,201,447,000 1,970,607,000 1,740,061,000 1,731,174,000 1,723,865,000 1,621,479,000 1,387,767,000 1,132,229,000 1,126,148,000 1,038,613,000 990,032,000 921,234,000 914,263,000 826,582,000 574,757,000 468,650,000 444,600,000 424,844,000 392,213,000 390,696,000 389,113,000 385,042,000 365,210,000 363,456,000 297,849,000 295,898,000 291,696,000 260,747,000 259,266,000 257,787,000 240,499,000 238,492,000 236,397,000 234,412,000 232,701,000 230,922,000 229,035,000 227,438,000 226,246,000 225,027,000  
      accumulated other comprehensive income:
    		                                                                  
      foreign currency translation adjustment
    		22,886,000 30,935,000 12,941,000 5,302,000 25,159,000 8,991,000 6,847,000 5,429,000 -6,573,000 4,337,000 -6,543,000 -11,989,000 -38,724,000 -16,603,000 -420,000 5,251,000 6,617,000 9,255,000 9,020,000 8,412,000 4,576,000 4,865,000 6,981,000 2,785,000 1,156,000 352,000 -1,309,000 495,000 -875,000 -1,539,000                                     
      unrealized loss on available-for-sale securities
    		-53,000 -129,000 -135,000 -207,000 -188,000 -197,000 -203,000 -188,000 -195,000 -177,000 -201,000 -116,000 -354,000 -637,000 -608,000  -184,000 -173,000 -185,000                                                
      warrants
    		   71,000 71,000 71,000 71,000 71,000 71,000 71,000 83,000 83,000 83,000 83,000 83,000 83,000 83,000   12,387,000 12,387,000 12,387,000 12,387,000 12,387,000 12,387,000 12,387,000 12,387,000 13,063,000 13,063,000 13,063,000 16,076,000 16,076,000 16,076,000 16,076,000 16,076,000 16,076,000 12,298,000                              
      accumulated deficit
    		-2,768,980,000 -2,786,286,000 -2,761,866,000 -2,740,180,000 -2,754,919,000 -2,748,190,000 -2,732,493,000 -2,684,074,000 -2,650,231,000 -2,628,654,000 -2,585,422,000 -2,532,490,000 -2,476,625,000 -2,443,339,000 -2,381,182,000 -2,295,922,000 -2,212,645,000 -2,162,351,000 -2,111,126,000 -2,045,462,000 -1,974,061,000 -1,910,050,000 -1,857,558,000 -1,768,610,000 -1,678,881,000 -1,617,072,000 -1,532,521,000 -1,412,222,000 -1,334,141,000 -1,174,978,000                                     
      total stockholders’ equity
    		230,424,000 204,304,000 193,558,000  178,825,000 132,523,000 130,694,000  133,237,000 111,581,000 102,573,000  132,565,000 173,425,000 238,617,000  376,629,000 213,910,000 250,896,000  320,269,000 360,953,000 402,594,000  548,267,000 600,058,000 451,668,000  410,951,000 561,895,000 521,617,000 409,680,000 266,892,000 310,778,000 336,555,000 334,243,000 311,632,000 378,755,000 328,902,000 104,010,000 43,277,000 36,308,000 31,084,000 26,489,000 39,559,000 53,337,000 76,759,000 73,167,000 80,776,000 36,789,000 44,607,000 53,061,000 50,491,000 64,362,000 74,194,000 37,162,000 48,641,000 60,257,000 71,043,000 83,015,000 89,666,000 97,685,000     
      total liabilities and stockholders’ equity
    		868,811,000 815,303,000 789,839,000  786,557,000 749,484,000 721,789,000  764,084,000 730,093,000 700,519,000  759,528,000 800,589,000 826,938,000  956,675,000 786,892,000 810,034,000  900,542,000 701,451,000 738,349,000  882,292,000 918,033,000 764,702,000  838,589,000 825,889,000 870,005,000 680,779,000 938,966,000 993,381,000 918,180,000 914,006,000 862,907,000 986,692,000 403,913,000 192,616,000 125,487,000 117,994,000 112,357,000 69,106,000 82,335,000 93,216,000 118,211,000 111,598,000 120,801,000 78,867,000 90,288,000 102,551,000 63,762,000 74,886,000 88,137,000 98,892,000 108,676,000 116,375,000 128,773,000 143,165,000 151,083,000 159,532,000  124,833,000   
      property and equipment, less accumulated depreciation of 30,991 and 28,775 at june 30, 2025 and december 31, 2024, respectively
    		 28,570,000                                                                 
      intangible assets, less accumulated amortization of 7,430 and 5,802 at june 30, 2025 and december 31, 2024, respectively
    		 15,570,000                                                                 
      common stock in treasury, at cost; 7,390 shares as of june 30, 2025
    		 -71,000                                                                 
      property and equipment, less accumulated depreciation of 29,842 and 28,775 at march 31, 2025 and december 31, 2024, respectively
    		  28,718,000                                                                
      intangible assets, less accumulated amortization of 6,611 and 5,802 at march 31, 2025 and december 31, 2024, respectively
    		  16,389,000                                                                
      common stock in treasury, at cost; 7,390 shares as of march 31, 2025
    		  -71,000                                                                
      property and equipment, less accumulated depreciation of 28,775 and 25,429 at december 31, 2024 and 2023, respectively
    		   29,383,000                                                               
      intangible assets, less accumulated amortization of 5,802 and 2,510 at december 31, 2024 and december 31, 2023, respectively
    		   17,198,000                                                               
      liabilities and stockholders' equity
    		                                                                  
      stockholders' equity:
    		                                                                  
      accumulated other comprehensive gain:
    		                                                                  
      total stockholders' equity
    		   194,045,000    160,174,000    123,047,000    307,369,000    286,380,000    476,425,000    342,912,000                                       
      total liabilities and stockholders' equity
    		   785,033,000    777,880,000    724,167,000    905,140,000    886,520,000    850,207,000    789,951,000                                     131,583,000  
      property and equipment, less accumulated depreciation of 29,324 and 25,429 at september 30, 2024 and december 31, 2023, respectively
    		    30,438,000                                                              
      intangible assets, less accumulated amortization of 4,974 and 2,510 at september 30, 2024 and december 31, 2023, respectively
    		    18,026,000                                                              
      property and equipment, less accumulated depreciation of 27,844 and 25,429 at june 30, 2024 and december 31, 2023, respectively
    		     31,161,000                                                             
      intangible assets, less accumulated amortization of 4,147 and 2,510 at june 30, 2024 and december 31, 2023, respectively
    		     18,853,000                                                             
      property and equipment, less accumulated depreciation of 26,563 and 25,429 at march 31, 2024 and december 31, 2023, respectively
    		      32,421,000                                                            
      intangible assets, less accumulated amortization of 3,328 and 2,510 at march 31, 2024 and december 31, 2023, respectively
    		      19,672,000                                                            
      accumulated other comprehensive loss:
    		                                                                  
      property and equipment, less accumulated depreciation of 25,429 and 22,281 at december 31, 2023 and 2022, respectively
    		       31,667,000                                                           
      intangible assets, less accumulated amortization of 2,510 and 0 at december 31, 2023 and december 31, 2022, respectively
    		       20,490,000                                                           
      contingent consideration payable
    		         13,005,000 12,668,000 21,417,000 19,833,000 19,266,000 19,151,000 18,900,000 17,000,000 19,800,000 19,600,000 8,900,000 16,561,000 20,027,000 23,612,000 22,681,000 22,036,000 21,247,000 20,767,000  8,800,000 8,600,000 8,700,000 12,900,000 219,162,000 218,199,000     11,800,000 11,700,000 10,200,000 10,800,000 11,105,000                        
      property and equipment, less accumulated depreciation of 25,018 and 22,281 at september 30, 2023 and december 31, 2022, respectively
    		        31,072,000                                                          
      intangible assets, less accumulated amortization of 1,682 and 0 at september 30, 2023 and december 31, 2022, respectively
    		        21,318,000                                                          
      deferred reimbursements
    		        5,906,000 5,906,000 5,906,000 4,656,000 5,906,000 5,906,000 5,906,000 5,906,000 7,406,000 7,406,000 7,406,000 7,406,000 8,906,000 8,906,000 1,250,000 1,250,000 5,250,000 2,750,000 2,750,000 5,500,000 2,750,000 2,750,000 7,750,000 16,906,000 16,906,000 21,906,000 35,756,000 35,756,000 35,756,000 36,620,000 36,620,000 36,620,000 36,677,000 36,677,000 36,677,000 34,019,000 32,709,000 31,685,000                     
      deferred income taxes
    		           4,939,000 4,930,000 4,930,000 4,930,000 4,930,000 4,896,000 4,896,000 4,896,000 4,896,000 5,051,000 5,051,000 5,051,000 5,051,000 6,465,000 6,465,000 6,465,000 6,465,000 6,465,000 6,465,000 6,465,000 9,186,000 173,869,000 173,820,000                                 
      property and equipment, less accumulated depreciation of 24,060 and 22,281 at june 30, 2023 and december 31, 2022, respectively
    		         30,238,000                                                         
      intangible assets, less accumulated amortization of 855 and 0 at june 30, 2023 and december 31, 2022, respectively
    		         22,145,000                                                         
      property and equipment, less accumulated depreciation of 22,901 and 22,281 at march 31, 2023 and december 31, 2022, respectively
    		          31,406,000                                                        
      intangible assets, less accumulated amortization of 36 and 0 at march 31, 2023 and december 31, 2022, respectively
    		          22,964,000                                                        
      property and equipment, less accumulated depreciation of 22,281 and 19,882 at december 31, 2022 and 2021, respectively
    		           30,778,000                                                       
      in-process research & development
    		           23,000,000 23,000,000 23,000,000 23,000,000 23,000,000 23,000,000 23,000,000 23,000,000 23,000,000 23,000,000 23,000,000 23,000,000 23,000,000 23,000,000 23,000,000 23,000,000 23,000,000 23,000,000 23,000,000 23,000,000 23,000,000 486,700,000 486,700,000 486,700,000 486,700,000 486,700,000 518,810,000 23,000,000 23,000,000 23,000,000 23,000,000 23,000,000                        
      property and equipment, less accumulated depreciation of 23,337 and 19,882 at september 30, 2022 and december 31, 2021, respectively
    		            32,449,000                                                      
      property and equipment, less accumulated depreciation of 22,188 and 19,882 at june 30, 2022 and december 31, 2021, respectively
    		             33,657,000                                                     
      property and equipment, less accumulated depreciation of 20,966 and 19,882 at march 31, 2022 and december 31, 2021, respectively
    		              34,544,000                                                    
      property and equipment, less accumulated depreciation of 19,882 and 14,487 at december 31, 2021 and december 31, 2020, respectively
    		               42,496,000                                                   
      unrealized loss on available-for securities
    		               -270,000            -427,000                                       
      property and equipment, less accumulated depreciation of 18,789 and 14,487 at september 30, 2021 and december 31, 2020, respectively
    		                41,991,000                                                  
      operating lease right-of-use assets, less accumulated amortization of 8,150 and 7,574 at june 30, 2021 and december 31, 2020, respectively
    		                 22,028,000                                                 
      property and equipment, less accumulated depreciation of 17,410 and 14,487 at june 30, 2021 and december 31, 2020, respectively
    		                 42,365,000                                                 
      operating lease right-of-use assets, less accumulated amortization of 7,499 and 7,574 at march 31, 2021 and december 31, 2020, respectively
    		                  22,363,000                                                
      property and equipment, less accumulated depreciation of 15,961 and 14,487 at march 31, 2021 and december 31, 2020, respectively
    		                  43,445,000                                                
      operating lease right-of-use assets, less accumulated amortization of 7,574 and 5,342 at december 31, 2020 and december 31, 2019, respectively
    		                   23,296,000                                               
      property and equipment, less accumulated depreciation of 14,487 and 17,604 at december 31, 2020 and december 31, 2019, respectively
    		                   43,863,000                                               
      unrealized gain on available-for securities
    		                   -185,000    40,000         31,000 185,000                                 
      operating lease right-of-use assets, less accumulated amortization of 6,850 and 5,342 at september 30, 2020 and december 31, 2019, respectively
    		                    23,397,000                                              
      property and equipment, less accumulated depreciation of 23,582 and 17,604 at september 30, 2020 and december 31, 2019, respectively
    		                    44,618,000                                              
      unrealized gain on available-for-sale securities
    		                    -56,000 288,000 -169,000  124,000 355,000 157,000  -211,000 -455,000                                     
      operating lease right-of-use assets, less accumulated amortization of 6,219 and 5,342 at june 30, 2020 and december 31, 2019, respectively
    		                     23,949,000                                             
      property and equipment, less accumulated depreciation of 21,194 and 17,604 at june 30, 2020 and december 31, 2019, respectively
    		                     46,945,000                                             
      convertible notes
    		                     2,203,000 2,167,000 2,131,000 2,096,000 2,070,000 22,052,000 175,006,000 172,186,000 169,440,000 166,768,000 161,635,000 159,171,000 156,859,000                                 
      senior secured term loan
    		                     147,834,000 147,569,000 147,374,000 147,164,000 146,994,000 146,766,000 146,734,000 146,622,000                                      
      operating lease right-of-use assets, less accumulated amortization of 6,260 and 5,342 at march 31, 2020 and december 31, 2019, respectively
    		                      32,501,000                                            
      property and equipment, less accumulated depreciation of 19,260 and 17,604 at march 31, 2020 and december 31, 2019, respectively
    		                      47,688,000                                            
      operating lease right-of-use assets, less accumulated amortization of 5,342 and 0 at december 31, 2019 and december 31, 2018, respectively
    		                       33,315,000                                           
      property and equipment, less accumulated depreciation of 17,604 and 15,671 at december 31, 2019 and december 31, 2018, respectively
    		                       47,705,000                                           
      accounts payable, accrued expenses, and other current liabilities
    		                       120,373,000 81,475,000 84,119,000 60,596,000 80,625,000 54,330,000 41,613,000 43,678,000 53,709,000 35,645,000 39,645,000                                 
      operating lease right-of-use assets, less accumulated amortization of 2,420 and 0 at september 30, 2019 and december 31, 2018, respectively
    		                        35,814,000                                          
      property and equipment, less accumulated depreciation of 17,907 and 15,671 at september 30, 2019 and december 31, 2018, respectively
    		                        34,673,000                                          
      operating lease right-of-use assets, less accumulated amortization of 2,641 and 0 at june 30, 2019 and december 31, 2018, respectively
    		                         35,052,000                                         
      property and equipment, less accumulated depreciation of 16,890 and 15,671 at june 30, 2019 and december 31, 2018, respectively
    		                         15,273,000                                         
      operating and finance lease right-of-use assets, less accumulated amortization of 2,111 and 0 at march 31, 2019 and december 31, 2018, respectively
    		                          36,308,000                                        
      property and equipment, less accumulated depreciation of 15,794 and 15,671 at march 31, 2019 and december 31, 2018, respectively
    		                          13,286,000                                        
      operating and finance lease liabilities
    		                          2,523,000                                        
      property and equipment, less accumulated depreciation of 15,671 and 12,515 at december 31, 2018 and 2017, respectively
    		                           11,375,000                                       
      property and equipment, less accumulated depreciation of 15,483 and 12,515 at september 30, 2018 and december 31, 2017, respectively
    		                            10,659,000                                      
      property and equipment, less accumulated depreciation of 14,415 and 12,515 at june 30, 2018 and december 31, 2017, respectively
    		                             9,111,000                                     
      other non-current liability
    		                             2,770,000 2,494,000 2,313,000 2,283,000 2,223,000     504,000 870,000 514,000 748,000 723,000                        
      property and equipment, less accumulated depreciation of 13,461 and 12,515 at march 31, 2018 and december 31, 2017, respectively
    		                              8,910,000                                    
      derivative liability
    		                              80,577,000                                    
      investments in marketable securities, current portion
    		                               347,388,000                                   
      property and equipment, less accumulated depreciation of 13,273 and 12,495 at september 30, 2017 and december 31, 2016, respectively
    		                               9,641,000                                   
      deferred reimbursements, current portion
    		                               6,250,000 18,850,000 13,850,000                                 
      contingent consideration payable, current portion
    		                               8,200,000 46,188,000 56,101,000 55,992,000 56,000,000                               
      property and equipment, less accumulated depreciation of 13,951 and 12,495 at june 30, 2017 and december 31, 2016, respectively
    		                                10,471,000                                  
      foreign currency translation adjustment, less tax expense of 1,293 at june 30, 2017 and december 31, 2016
    		                                                                  
      property and equipment, less accumulated depreciation of 13,316 and 12,495 at march 31, 2017 and december 31, 2016, respectively
    		                                 9,745,000                                 
      foreign currency translation adjustment, less tax expense of 1,293 at march 31, 2017 and december 31, 2016
    		                                 1,487,000                                 
      assets:
    		                                                                  
      property and equipment, less accumulated depreciation of 15,181 and 13,353 at september 30, 2016 and december 31, 2015, respectively
    		                                  10,183,000                                
      accounts payable and accrued expenses
    		                                  29,013,000 23,828,000 22,501,000 30,565,000 16,901,000 15,833,000 11,331,000 9,918,000 9,167,000 8,166,000 9,018,000 6,427,000 9,428,000 9,067,000 8,449,000 8,098,000 7,019,000 7,418,000 6,809,000 5,752,000 7,358,000 12,759,000 10,988,000 8,683,000 8,796,000 9,804,000 10,745,000      
      other current liabilities
    		                                  607,000 631,000                               
      due to related party
    		                                  44,047,000 43,443,000 38,509,000 50,000,000                             
      unsecured notes payable
    		                                  21,977,000 21,851,000                               
      contingent consideration payable, less current portion
    		                                  216,198,000 220,300,000 235,303,000 277,684,000                             
      deferred tax liability
    		                                  176,219,000 176,219,000 176,219,000 207,213,000 9,186,000 9,186,000 9,186,000 9,186,000 9,186,000                        
      foreign currency translation adjustment, less tax benefit of 706 at september 30, 2016
    		                                  1,062,000                                
      unrealized gain/ (loss) on available-for securities
    		                                  287,000 201,000 114,000                              
      property and equipment, less accumulated depreciation of 14,284 and 13,353 at june 30, 2016 and december 31, 2015, respectively
    		                                   10,178,000                               
      foreign currency translation adjustment, less tax benefit of 453 at june 30, 2016
    		                                   842,000                               
      property and equipment, less accumulated depreciation of 13,996 and 13,353 at march 31, 2016 and december 31, 2015, respectively
    		                                    8,413,000                              
      current portion of contingent consideration payable
    		                                    41,926,000 5,300,000                             
      property and equipment, less accumulated depreciation of 12,776 and 11,520 at september 30, 2015 and december 31, 2014, respectively
    		                                     3,855,000                             
      current portion of secured loan
    		                                       5,189,000 2,493,000 1,253,000 199,000 398,000 398,000 398,000 502,000 816,000 1,129,000 1,253,000 1,253,000 1,253,000 1,253,000 1,253,000 1,253,000 1,148,000 868,000          
      secured loan, less current portion
    		                                       9,208,000 11,809,000 13,104,000 14,216,000  100,000 199,000 398,000 498,000 597,000 104,000 418,000 731,000 1,357,000 1,670,000 1,983,000 2,610,000 1,987,000          
      accumulated other comprehensive loss
    		                                                 -25,000 -14,000                
      property and equipment, less accumulated depreciation of 12,381 and 11,520 at june 30, 2015 and december 31, 2014, respectively
    		                                      3,379,000                            
      accumulated other comprehensive income
    		                                        2,000  2,000 5,000 3,000 15,000 37,000 17,000 37,000   1,000 11,000 6,000 2,000 88,000 145,000 234,000 533,000 68,000 318,000 930,000 408,000 220,000 113,000  
      property and equipment, less accumulated depreciation of 12,028 and 11,520 at march 31, 2015 and december 31, 2014, respectively
    		                                       3,056,000                           
      receivable due from collaboration agreements
    		                                        293,000 475,000                         
      property and equipment, less accumulated depreciation and amortization of 9,973 and 11,157 at december 31, 2013 and september 30, 2014, respectively
    		                                        3,129,000                          
      property and equipment, less accumulated depreciation and amortization of 9,973 and 10,781 at december 31, 2013 and june 30, 2014, respectively
    		                                         3,444,000                         
      receivable due from gsk
    		                                          38,000 2,121,000 1,024,000 1,308,000 3,184,000 7,237,000 4,301,000 3,828,000 1,977,000 3,969,000               
      property and equipment, less accumulated depreciation and amortization of 9,973 and 10,385 at december 31, 2013 and march 31, 2014, respectively
    		                                          3,748,000                        
      deficit accumulated during the development stage
    		                                                 -261,442,000 -251,683,000 -239,042,000 -210,604,000 -195,247,000 -183,932,000 -203,712,000 -190,283,000 -176,661,000 -164,189,000 -150,039,000 -141,859,000 -132,565,000 -124,834,000 -113,061,000 -102,758,000 -83,667,000 
      property and equipment, less accumulated depreciation and amortization of 8,501 and 9,751 at december 31, 2012 and september 30, 2013, respectively
    		                                           4,356,000                       
      warrant liability
    		                                           34,000 551,000 1,170,000 3,889,000 4,442,000 4,324,000 2,690,000 6,066,000 8,144,000 3,766,000 1,707,000 3,098,000            
      warrant liability, non-current
    		                                                                  
      property and equipment, less accumulated depreciation and amortization of 8,501 and 9,321 at december 31, 2012 and june 30, 2013, respectively
    		                                            4,715,000                      
      property and equipment, less accumulated depreciation and amortization of 8,501 and 8,872 at december 31, 2012 and march 31, 2013, respectively
    		                                             4,962,000                     
      property and equipment, less accumulated depreciation and amortization of 9,507 and 8,080 at december 31, 2011 and september 30, 2012, respectively
    		                                              5,293,000                    
      current portion of deferred reimbursements
    		                                                                  
      deferred reimbursements, less current portion
    		                                              27,235,000                    
      property and equipment, less accumulated depreciation and amortization of 9,507 and 7,658 at december 31, 2011 and june 30, 2012, respectively
    		                                               5,489,000                   
      current portion of deferred revenue
    		                                               7,929,000 8,187,000 9,274,000 8,606,000 7,965,000    2,778,000 2,778,000 3,176,000 3,705,000 4,043,000 3,295,000 4,612,000 3,801,000    
      deferred revenue, less current portion
    		                                               15,679,000 17,339,000 20,659,000 22,319,000 23,979,000    41,952,000 42,647,000 43,341,000 44,035,000 44,730,000 45,424,000 46,119,000 46,813,000    
      property and equipment, less accumulated depreciation and amortization of 9,507 and 7,216 at december 31, 2011 and march 31, 2012, respectively
    		                                                5,073,000                  
      property and equipment, accumulated depreciation and amortization of 8,095 and 9,338 at december 31, 2010 and september 30, 2011, respectively
    		                                                 1,759,000                 
      current portion of capital lease obligations
    		                                                    86,000 142,000 227,000 397,000 603,000 695,000 877,000 1,090,000 1,258,000 1,420,000 1,527,000 1,521,000 1,504,000  
      property and equipment, accumulated depreciation and amortization of 8,095 and 8,959 at december 31, 2010 and june 30, 2011, respectively
    		                                                  1,922,000                
      property and equipment, less accumulated depreciation and amortization of 8,095 and 8,533 at december 31, 2010 and march 31, 2011, respectively
    		                                                   2,237,000               
      property and equipment, less accumulated depreciation and amortization of 6,340 and 7,917 at december 31, 2009 and september 30, 2010, respectively
    		                                                    3,017,000              
      capital lease obligations, less current portion
    		                                                      24,000 86,000 164,000 223,000 317,000 483,000 695,000 918,000 1,194,000 1,573,000 1,953,000  
      property and equipment, less accumulated depreciation and amortization of 6,340 and 7,406 at december 31, 2009 and june 30, 2010, respectively
    		                                                     3,472,000             
      property and equipment, less accumulated depreciation and amortization of 6,340 and 6,877 at december 31, 2009 and march 31, 2010, respectively
    		                                                      3,934,000            
      property and equipment, less accumulated depreciation and amortization of 4,260 and 5,832 at december 31, 2008 and september 30, 2009, respectively
    		                                                       5,049,000           
      property and equipment, less accumulated depreciation and amortization of 4,260 and 5,271 at december 31, 2008 and june 30, 2009, respectively
    		                                                        5,326,000          
      property and equipment, less accumulated depreciation and amortization of 4,260 and 4,762 at december 31, 2008 and march 31, 2009, respectively
    		                                                         5,076,000         
      property and equipment, less accumulated depreciation and amortization of 2,793 and 4,260 at december 31, 2007 and 2008, respectively
    		                                                          4,919,000        
      property and equipment, less accumulated depreciation and amortization of 2,793 and 3,804 at december 31, 2007 and september 30, 2008, respectively
    		                                                           4,416,000       
      property and equipment, less accumulated depreciation and amortization of 2,793 and 3,421 at december 31, 2007 and june 30, 2008, respectively
    		                                                            4,195,000      
      property and equipment, less accumulated depreciation and amortization of 2,793 and 3,114 at december 31, 2007 and march 31, 2008, respectively
    		                                                             3,631,000     
      accrued expenses
    		                                                             7,728,000 9,935,000 7,515,000 5,123,000  
      stockholders’equity:
    		                                                                  
      property and equipment, less accumulated depreciation and amortization of 1,557 and 2,793 at december 31, 2006 and 2007, respectively
    		                                                              3,790,000    
      liabilities and stockholders’ (deficiency) equity
    		                                                                  
      series a redeemable convertible preferred stock, .01 par value, 444,443 shares authorized, issued and outstanding at december 31, 2006 (aggregate liquidation preference 2,500 at december 31, 2006), no shares authorized, issued, or outstanding at december 31, 2007
    		                                                                  
      series b redeemable convertible preferred stock, .01 par value, 4,936,730 shares authorized, 4,877,056 shares issued and outstanding at december 31, 2006 (aggregate liquidation preference 31,000 at december 31, 2006), no shares authorized, issued, or outstanding at december 31, 2007
    		                                                                  
      series c redeemable convertible preferred stock, .01 par value, 5,820,020 shares authorized, issued and outstanding at december 31, 2006 (aggregate liquidation preferences 54,999 at december 31, 2006), no shares authorized, issued, or outstanding at december 31, 2007
    		                                                                  
      series d redeemable convertible preferred stock, .01 par value, 4,930,405 shares authorized, 2,953,878 issued and outstanding at december 31, 2006 (aggregate liquidation preference 36,000), no shares authorized, issued, or outstanding at december 31, 2007
    		                                                                  
      stockholders’ (deficiency) equity:
    		                                                                  
      total stockholders’ (deficiency) equity
    		                                                              103,297,000 113,689,000 122,665,000 -77,515,000 
      total liabilities and stockholders’ (deficiency) equity
    		                                                              167,097,000    
      property and equipment, less accumulated depreciation and amortization of 1,557 and 2,478 at december 31, 2006 and september 30, 2007, respectively
    		                                                               3,913,000   
      series a redeemable convertible preferred stock, .01 par value, 444,443 shares authorized, issued and outstanding at december 31, 2006 (aggregate liquidation preference 2,500 at december 31, 2006), no shares authorized, issued, or outstanding at september 30, 2007
    		                                                                  
      series b redeemable convertible preferred stock, .01 par value, 4,936,730 shares authorized, 4,877,056 shares issued and outstanding at december 31, 2006 (aggregate liquidation preference 31,000 at december 31, 2006), no shares authorized, issued, or outstanding at september 30, 2007
    		                                                                  
      series c redeemable convertible preferred stock, .01 par value, 5,820,020 shares authorized, issued and outstanding at december 31, 2006 (aggregate liquidation preferences 54,999 at december 31, 2006), no shares authorized, issued, or outstanding at september 30, 2007
    		                                                                  
      series d redeemable convertible preferred stock, .01 par value, 4,930,405 shares authorized, 2,953,878 issued and outstanding at december 31, 2006 (aggregate liquidation preference 36,000), no shares authorized, issued, or outstanding at september 30, 2007
    		                                                                  
      property and equipment, less accumulated depreciation and amortization of 1,557 and 2,166 at december 31, 2006 and june 30, 2007, respectively
    		                                                                4,161,000  
      series a redeemable convertible preferred stock, .01 par value, 444,443 shares authorized, issued and outstanding at december 31, 2006 (aggregate liquidation preference 2,500 at december 31, 2006), no shares authorized, issued, or outstanding at june 30, 2007
    		                                                                  
      series b redeemable convertible preferred stock, .01 par value, 4,936,730 shares authorized, 4,877,056 shares issued and outstanding at december 31, 2006 (aggregate liquidation preference 31,000 at december 31, 2006), no shares authorized, issued, or outstanding at june 30, 2007
    		                                                                  
      series c redeemable convertible preferred stock, .01 par value, 5,820,020 shares authorized, issued and outstanding at december 31, 2006 (aggregate liquidation preferences 54,999 at december 31, 2006), no shares authorized, issued, or outstanding at june 30, 2007
    		                                                                  
      series d redeemable convertible preferred stock, .01 par value, 4,930,405 shares authorized, 2,953,878 issued and outstanding at december 31, 2006 (aggregate liquidation preference 36,000), no shares authorized, issued, or outstanding at june 30, 2007
    		                                                                  
      balance sheet data:
    		                                                                  
      cash and cash equivalents and marketable securities
    		                                                                 54,699,000 
      working capital
    		                                                                 44,814,000 
      redeemable convertible preferred stock
    		                                                                 124,089,000 
    The information provided in this report is taken from www.sec.gov and many other data providers. While we have conducted our best efforts to ensure that the parsed data is accurate, we cannot guarantee its accuracy. Please use caution and understand that any consequences of its use are your own responsibility.