Dyne Therapeutics, Inc(NASDAQ:DYN) 
Dyne Therapeutics, Inc., a muscle disease company, operates as a biotechnology company that focuses on advancing therapeutics for genetically driven muscle diseases in the United States. It develops various programs for myotonic dystrophy type 1, duchenne muscular dystrophy, and facioscapulohumeral ...
Website: http://www.dyne-tx.com
Founded: 2017
Full Time Employees: 36
CEO: Joshua T. Brumm
Sector: Other
Industry: Other
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At a glance:
Bull Thesis:
Bear Thesis:
Main Competitors:
Moat:
Income Statements:
Quarterly
Annual
| Unit: USD | 2026-03-31 | 2025-12-31 | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
operating expenses: | |||||||||||||||||||||||
research and development | 100,889,000 | 95,431,000 | 97,219,000 | 99,236,000 | 106,447,000 | 81,805,000 | 92,800,000 | 62,263,000 | 44,539,000 | 58,844,000 | 55,251,000 | 59,130,000 | 37,536,000 | 33,190,000 | 34,670,000 | 46,664,000 | 28,236,000 | 42,301,000 | 36,510,000 | 23,872,000 | 18,625,000 | 22,098,000 | 9,679,000 |
general and administrative | 24,387,000 | 20,698,000 | 16,673,000 | 16,555,000 | 15,925,000 | 15,303,000 | 12,859,000 | 9,699,000 | 24,618,000 | 8,844,000 | 7,022,000 | 7,606,000 | 7,928,000 | 6,955,000 | 7,609,000 | 6,091,000 | 7,547,000 | 9,659,000 | 6,256,000 | 6,293,000 | 6,509,000 | 6,502,000 | 3,841,000 |
total operating expenses | 125,276,000 | 116,129,000 | 113,892,000 | 115,791,000 | 122,372,000 | 97,108,000 | 105,659,000 | 71,962,000 | 69,157,000 | 67,688,000 | 62,273,000 | 66,736,000 | 45,464,000 | 40,145,000 | 42,279,000 | 52,755,000 | 35,783,000 | 51,960,000 | 42,766,000 | 30,165,000 | 25,134,000 | 28,600,000 | 13,520,000 |
income from operations | -125,276,000 | -116,129,000 | -113,892,000 | -115,791,000 | -122,372,000 | -97,108,000 | -105,659,000 | -71,962,000 | -69,157,000 | -67,688,000 | -62,273,000 | -66,736,000 | -45,464,000 | -40,145,000 | -42,279,000 | -52,755,000 | -35,783,000 | -51,960,000 | -42,766,000 | -30,165,000 | -25,134,000 | -28,600,000 | -13,520,000 |
yoy | 2.37% | 19.59% | 7.79% | 60.91% | 76.95% | 43.46% | 69.67% | 7.83% | 52.11% | 68.61% | 47.29% | 26.50% | 27.05% | -22.74% | -1.14% | 74.89% | 42.37% | 81.68% | 216.32% | ||||
qoq | 7.88% | 1.96% | -1.64% | -5.38% | 26.02% | -8.09% | 46.83% | 4.06% | 2.17% | 8.70% | -6.69% | 46.79% | 13.25% | -5.05% | -19.86% | 47.43% | -31.13% | 21.50% | 41.77% | 20.02% | -12.12% | 111.54% | |
other income: | |||||||||||||||||||||||
interest income | 8,757,000 | 7,657,000 | 8,476,000 | 6,625,000 | 7,100,000 | 7,592,000 | 9,276,000 | 7,052,000 | 3,002,000 | 1,751,000 | 2,189,000 | 2,207,000 | 1,493,000 | 1,342,000 | 903,000 | 441,000 | 230,000 | 182,000 | 184,000 | 210,000 | 166,000 | 32,000 | |
interest expense | -4,202,000 | -3,194,000 | -2,904,000 | -94,000 | -81,000 | -130,000 | |||||||||||||||||
other expense | -133,000 | ||||||||||||||||||||||
total other income | 4,422,000 | 4,174,000 | 5,851,000 | 4,934,000 | 7,011,000 | 7,566,000 | 8,534,000 | 6,860,000 | 3,508,000 | 1,050,000 | 2,063,000 | 1,834,000 | 1,277,000 | 1,318,000 | 894,000 | 451,000 | 200,000 | 174,000 | 184,000 | 210,000 | 166,000 | -49,000 | -400,000 |
net income | -120,854,000 | -111,955,000 | -108,041,000 | -110,857,000 | -115,361,000 | -89,542,000 | -97,125,000 | -65,102,000 | -65,649,000 | -66,638,000 | -60,210,000 | -64,902,000 | -44,187,000 | -38,827,000 | -41,385,000 | -52,304,000 | -35,583,000 | -51,786,000 | -42,582,000 | -29,955,000 | -24,968,000 | -28,649,000 | -13,920,000 |
yoy | 4.76% | 25.03% | 11.24% | 70.28% | 75.72% | 34.37% | 61.31% | 0.31% | 48.57% | 71.63% | 45.49% | 24.09% | 24.18% | -25.02% | -2.81% | 74.61% | 42.51% | 80.76% | 205.91% | ||||
qoq | 7.95% | 3.62% | -2.54% | -3.90% | 28.83% | -7.81% | 49.19% | -0.83% | -1.48% | 10.68% | -7.23% | 46.88% | 13.80% | -6.18% | -20.88% | 46.99% | -31.29% | 21.61% | 42.15% | 19.97% | -12.85% | 105.81% | |
net income per share | -0.73 | -0.73 | -0.76 | -0.97 | -1.05 | -0.88 | -0.96 | -0.7 | -0.81 | -1.09 | -0.99 | -1.08 | -0.78 | -0.73 | -0.8 | -1.01 | -0.69 | -1.01 | -0.83 | -0.58 | -0.5 | 3.38 | -2.01 |
weighted-average common shares outstanding, basic and diluted | 165,036,604 | 128,442,723 | 141,810,881 | 113,873,126 | 109,911,628 | 94,143,565 | 100,882,042 | 92,507,815 | 81,043,741 | 59,683,851 | 61,109,917 | 59,835,087 | 56,325,864 | 51,976,343 | 50,895,044 | 14,395,955 | |||||||
comprehensive loss: | |||||||||||||||||||||||
other comprehensive loss: | |||||||||||||||||||||||
unrealized gains on marketable securities | -612 | -21 | 244 | 11 | 235 | -472 | 718 | -108 | -132 | 13 | 43 | 147 | 368 | 412 | 173 | -226 | -661 | -235 | 7 | 27 | -41 | ||
comprehensive loss | -121,466 | -111,976 | -107,797 | -110,846 | -115,126 | -90,014 | -96,407 | -65,210 | -65,781 | -66,625 | -60,167 | -64,755 | -43,819 | -38,415 | -41,212 | -52,530 | -36,244 | -52,021 | -42,575 | -29,928 | -25,009 | ||
other income | -352,000 | 279,000 | -1,597,000 | -89,000 | -107,000 | -742,000 | -192,000 | 506,000 | -701,000 | -126,000 | -373,000 | -216,000 | -24,000 | -9,000 | 10,000 | -30,000 | |||||||
weighted-average common shares outstanding used in net loss per share—basic and diluted | 51,795,446 | 51,679,536 | 51,601,444 | 51,320,940 | 51,216,254 | 49,472,497 | 6,920,008 | ||||||||||||||||
change in success fee obligation | -270,000 | ||||||||||||||||||||||
change in fair value of preferred stock tranche obligations |
Balance Sheets:
Quarterly
Annual
| Unit: USD | 2026-03-31 | 2025-12-31 | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
assets | |||||||||||||||||||||||
current assets: | |||||||||||||||||||||||
cash and cash equivalents | 753,102,000 | 893,369,000 | 573,610,000 | 485,040,000 | 472,255,000 | 435,449,000 | 532,163,000 | 608,196,000 | 272,035,000 | 121,626,000 | 130,279,000 | 167,608,000 | 181,114,000 | 172,147,000 | 144,901,000 | 135,980,000 | 147,965,000 | 200,825,000 | 229,042,000 | 258,385,000 | 310,949,000 | 300,852,000 | 379,606,000 |
marketable securities | 219,054,000 | 217,193,000 | 218,277,000 | 198,885,000 | 205,237,000 | 206,819,000 | 191,511,000 | 170,642,000 | 181,512,000 | 1,474,000 | 27,544,000 | 40,125,000 | 57,097,000 | 83,865,000 | 103,241,000 | 155,858,000 | 175,185,000 | 175,746,000 | 178,481,000 | 177,204,000 | 172,136,000 | 44,462,000 | |
prepaid expenses and other current assets | 48,871,000 | 16,025,000 | 14,376,000 | 14,025,000 | 12,011,000 | 17,011,000 | 12,716,000 | 13,482,000 | 34,594,000 | 6,275,000 | 10,393,000 | 5,440,000 | 11,003,000 | 9,582,000 | 10,092,000 | 6,096,000 | 21,300,000 | 5,821,000 | 17,132,000 | 25,708,000 | 3,983,000 | 3,773,000 | 234,000 |
total current assets | 1,021,027,000 | 1,126,587,000 | 806,263,000 | 697,950,000 | 689,503,000 | 659,279,000 | 736,390,000 | 792,320,000 | 488,141,000 | 129,375,000 | 168,216,000 | 213,173,000 | 249,214,000 | 265,594,000 | 258,234,000 | 297,934,000 | 344,450,000 | 382,392,000 | 424,655,000 | 461,297,000 | 487,068,000 | 349,087,000 | 379,840,000 |
property and equipment | 23,682,000 | 24,029,000 | 23,972,000 | 5,675,000 | 5,747,000 | 5,398,000 | 4,896,000 | 5,022,000 | 4,578,000 | 4,780,000 | 5,112,000 | 5,359,000 | 5,569,000 | 5,945,000 | 5,742,000 | 5,483,000 | 5,619,000 | 4,678,000 | 2,988,000 | 2,589,000 | 1,777,000 | 1,946,000 | 1,441,000 |
right-of-use assets | 19,652,000 | 20,742,000 | 21,818,000 | 22,859,000 | 23,882,000 | 24,615,000 | 25,621,000 | 26,615,000 | 27,640,000 | 28,612,000 | 29,591,000 | 30,566,000 | 31,538,000 | 32,467,000 | 33,386,000 | 34,294,000 | 35,380,000 | 36,282,000 | 36,927,000 | ||||
restricted cash and other assets | 15,589,000 | 15,600,000 | 15,006,000 | 2,508,000 | 2,317,000 | 2,315,000 | 2,313,000 | 2,311,000 | 2,308,000 | 2,885,000 | 2,303,000 | 2,301,000 | |||||||||||
total assets | 1,079,950,000 | 1,186,958,000 | 867,059,000 | 728,992,000 | 721,074,000 | 691,234,000 | 768,844,000 | 825,884,000 | 522,279,000 | 165,082,000 | 205,244,000 | 251,421,000 | 288,642,000 | 306,325,000 | 299,679,000 | 340,026,000 | 387,762,000 | 425,663,000 | 466,878,000 | 467,147,000 | 491,710,000 | 353,334,000 | 381,472,000 |
liabilities and stockholders’ equity | |||||||||||||||||||||||
current liabilities: | |||||||||||||||||||||||
accounts payable | 10,781,000 | 8,082,000 | 12,061,000 | 14,016,000 | 7,019,000 | 6,562,000 | 6,157,000 | 1,889,000 | 7,214,000 | 22,936,000 | 3,553,000 | 2,724,000 | 8,770,000 | 5,259,000 | 919,000 | 6,972,000 | 5,188,000 | 4,031,000 | 7,088,000 | 5,649,000 | 5,760,000 | 3,440,000 | 1,488,000 |
accrued expenses and other current liabilities | 29,211,000 | 37,548,000 | 42,749,000 | 22,454,000 | 21,752,000 | 30,846,000 | 32,289,000 | 23,085,000 | 10,393,000 | 23,439,000 | 21,426,000 | 12,784,000 | 8,173,000 | 18,219,000 | 17,826,000 | 13,161,000 | 13,338,000 | 20,799,000 | 11,674,000 | 8,499,000 | 7,094,000 | 7,527,000 | 3,190,000 |
vendor financing arrangement | 6,224,000 | ||||||||||||||||||||||
lease liabilities | 5,033,000 | 4,995,000 | 5,039,000 | 5,002,000 | 5,111,000 | 4,850,000 | 4,814,000 | 4,779,000 | 4,756,000 | 4,720,000 | 4,713,000 | 4,713,000 | 4,644,000 | 4,610,000 | 4,576,000 | 5,489,000 | 4,711,000 | 3,893,000 | 4,589,000 | ||||
total current liabilities | 51,249,000 | 50,625,000 | 59,849,000 | 41,472,000 | 33,882,000 | 42,258,000 | 43,260,000 | 29,753,000 | 22,363,000 | 51,095,000 | 29,692,000 | 20,221,000 | 21,587,000 | 28,088,000 | 23,321,000 | 25,622,000 | 23,237,000 | 28,723,000 | 23,351,000 | 10,967,000 | 4,678,000 | ||
long-term debt | 149,375,000 | 148,921,000 | 99,147,000 | 98,813,000 | |||||||||||||||||||
lease liabilities, net of current portion | 14,271,000 | 15,283,000 | 16,280,000 | 17,262,000 | 18,219,000 | 19,138,000 | 20,044,000 | 20,938,000 | 21,861,000 | 22,695,000 | 23,514,000 | 24,323,000 | 25,120,000 | 25,873,000 | 26,614,000 | 27,345,000 | 28,066,000 | 28,743,000 | 29,411,000 | ||||
total liabilities | 214,895,000 | 214,829,000 | 175,276,000 | 157,547,000 | 52,101,000 | 61,396,000 | 63,304,000 | 50,691,000 | 44,224,000 | 73,790,000 | 53,206,000 | 44,544,000 | 46,707,000 | 53,961,000 | 49,935,000 | 52,967,000 | 51,303,000 | 57,466,000 | 52,762,000 | 14,551,000 | 13,450,000 | 10,967,000 | 14,627,000 |
stockholders’ equity | |||||||||||||||||||||||
preferred stock, 0.0001 par value... | |||||||||||||||||||||||
common stock, 0.0001 par value... | 16,000 | 16,000 | 14,000 | 11,000 | 11,000 | 10,000 | 10,000 | 10,000 | 9,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 5,000 | 5,000 |
additional paid-in capital | 2,382,172,000 | 2,367,780,000 | 1,975,460,000 | 1,747,328,000 | 1,734,010,000 | 1,579,750,000 | 1,565,438,000 | 1,538,684,000 | 1,176,337,000 | 723,796,000 | 717,917,000 | 712,589,000 | 682,892,000 | 649,502,000 | 608,467,000 | 604,570,000 | 601,440,000 | 596,934,000 | 590,832,000 | 586,737,000 | 582,473,000 | 421,572,000 | 417,374,000 |
accumulated other comprehensive loss | -137,000 | 496,000 | 252,000 | 241,000 | 6,000 | 478,000 | -240,000 | -132,000 | -13,000 | -56,000 | -203,000 | -571,000 | -983,000 | -1,156,000 | -930,000 | -269,000 | -34,000 | -41,000 | -68,000 | -27,000 | |||
accumulated deficit | -1,516,996,000 | -1,396,142,000 | -1,284,187,000 | -1,176,146,000 | -1,065,289,000 | -949,928,000 | -860,386,000 | -763,261,000 | -698,159,000 | -632,510,000 | -565,872,000 | -505,662,000 | -440,760,000 | -396,573,000 | -357,746,000 | -316,361,000 | -264,057,000 | -228,474,000 | -176,688,000 | -134,106,000 | -104,151,000 | -79,183,000 | -50,534,000 |
total stockholders’ equity | 865,055,000 | 972,129,000 | 691,783,000 | 571,445,000 | 668,973,000 | 629,838,000 | 705,540,000 | 775,193,000 | 478,055,000 | 91,292,000 | 152,038,000 | 206,877,000 | 241,935,000 | 252,364,000 | 249,744,000 | 287,059,000 | 336,459,000 | 368,197,000 | 414,116,000 | 452,596,000 | 478,260,000 | 342,367,000 | 366,845,000 |
total liabilities and stockholders’ equity | 1,079,950,000 | 1,186,958,000 | 867,059,000 | 728,992,000 | 721,074,000 | 691,234,000 | 768,844,000 | 825,884,000 | 522,279,000 | 165,082,000 | 205,244,000 | 251,421,000 | 288,642,000 | 306,325,000 | 299,679,000 | 340,026,000 | 387,762,000 | 425,663,000 | 466,878,000 | 467,147,000 | 491,710,000 | 353,334,000 | 381,472,000 |
accumulated other comprehensive gain | 475,000 | ||||||||||||||||||||||
restricted cash | 1,942,000 | 1,942,000 | 1,937,000 | 1,927,000 | 1,920,000 | 2,315,000 | 2,325,000 | 2,323,000 | 2,321,000 | 2,319,000 | |||||||||||||
commitments and contingencies | |||||||||||||||||||||||
right-of-use asset | 376,000 | 562,000 | |||||||||||||||||||||
lease liability | 403,000 | 596,000 | |||||||||||||||||||||
deferred rent | 13,000 | ||||||||||||||||||||||
convertible preferred stock | |||||||||||||||||||||||
other assets | 191,000 | ||||||||||||||||||||||
long-term debt—net of unamortized debt discount | 9,936,000 |
Cashflow Statements:
Quarterly
Annual
| Unit: USD | 2026-03-31 | 2025-12-31 | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cash flows from operating activities: | ||||||||||||||||||||||
net loss | -120,854,000 | -111,955,000 | -108,040,000 | -110,858,000 | -115,361,000 | -89,542,000 | -97,125,000 | -65,102,000 | -65,649,000 | -66,638,000 | -60,210,000 | -64,902,000 | -44,187,000 | -38,827,000 | -41,385,000 | -52,304,000 | -35,583,000 | -51,786,000 | -42,582,000 | -29,955,000 | -24,968,000 | -28,649,000 |
adjustments to reconcile net loss to net cash from operating activities: | ||||||||||||||||||||||
stock-based compensation expense | 13,081,000 | 11,226,000 | 11,082,000 | 10,523,000 | 13,020,000 | 10,477,000 | 8,745,000 | 6,736,000 | 19,906,000 | 5,730,000 | 4,876,000 | 4,749,000 | 4,617,000 | 3,832,000 | 3,827,000 | 3,031,000 | 4,488,000 | 6,013,000 | 3,638,000 | 4,239,000 | 3,652,000 | 4,215,000 |
depreciation and amortization expense | 550,000 | 521,000 | 523,000 | 503,000 | 502,000 | 450,000 | 438,000 | 399,000 | 386,000 | 399,000 | 431,000 | 431,000 | 412,000 | 401,000 | 397,000 | 460,000 | 425,000 | 341,000 | 260,000 | 249,000 | 238,000 | 217,000 |
non-cash lease expense | 116,000 | 35,000 | 96,000 | -43,000 | 75,000 | 136,000 | 136,000 | 125,000 | 173,000 | 168,000 | 166,000 | 243,000 | 211,000 | 214,000 | -735,000 | 1,142,000 | 1,041,000 | -718,000 | -13,000 | -8,000 | -7,000 | |
non-cash interest expense | 79,000 | 56,000 | 60,000 | |||||||||||||||||||
accretion of premium on marketable securities | -271,000 | -368,000 | -463,000 | -616,000 | -976,000 | -1,269,000 | -523,000 | |||||||||||||||
gain on sale of marketable securities | -30,000 | |||||||||||||||||||||
loss on disposal of property and equipment | 30,000 | 0 | 0 | 0 | 95,000 | 74,000 | 0 | 0 | -2,000 | 0 | 0 | 0 | 118,000 | |||||||||
changes in operating assets and liabilities: | ||||||||||||||||||||||
prepaid expenses and other current assets | -32,847,000 | -2,198,000 | 389,000 | -2,204,000 | 4,999,000 | -4,094,000 | 765,000 | -3,137,000 | -4,070,000 | 4,118,000 | -4,956,000 | 5,565,000 | -1,390,000 | 510,000 | -3,998,000 | 14,821,000 | -15,477,000 | 11,310,000 | 8,577,000 | -21,724,000 | 331,000 | |
other non-current assets | 28,000 | 350,000 | ||||||||||||||||||||
accounts payable and other liabilities | -4,804,000 | -9,463,000 | 18,470,000 | 7,845,000 | -8,601,000 | -991,000 | 13,414,000 | 7,380,000 | -28,758,000 | 21,411,000 | 9,456,000 | -1,366,000 | -6,531,000 | 4,646,000 | -1,157,000 | 1,544,000 | -6,268,000 | 6,027,000 | 4,833,000 | 973,000 | 1,869,000 | 7,453,000 |
net cash from operating activities | -144,922,000 | -111,832,000 | -90,779,000 | -94,703,000 | -105,893,000 | -84,335,000 | -74,629,000 | -54,868,000 | -78,537,000 | -35,006,000 | -50,602,000 | -55,642,000 | -46,908,000 | -29,192,000 | -42,805,000 | -30,909,000 | -50,739,000 | -28,068,000 | -26,952,000 | -46,150,000 | -18,393,000 | -20,036,000 |
capital expenditures | -144,000 | -484,000 | -395,000 | 275,000 | -952,000 | -1,075,000 | -253,000 | -857,000 | -164,000 | -97,000 | -150,000 | -279,000 | -191,000 | -519,000 | -886,000 | -198,000 | -1,234,000 | -1,949,000 | -1,103,000 | -414,000 | 50,000 | -723,000 |
free cash flows | -145,066,000 | -112,316,000 | -91,174,000 | -94,428,000 | -106,845,000 | -85,410,000 | -74,882,000 | -55,725,000 | -78,701,000 | -35,103,000 | -50,752,000 | -55,921,000 | -47,099,000 | -29,711,000 | -43,691,000 | -31,107,000 | -51,973,000 | -30,017,000 | -28,055,000 | -46,564,000 | -18,343,000 | -20,759,000 |
cash flows from investing activities: | ||||||||||||||||||||||
purchases of property and equipment | -221,000 | -484,000 | -395,000 | -60,000 | -981,000 | -1,075,000 | -253,000 | -857,000 | -191,000 | -82,000 | -167,000 | -250,000 | -230,000 | -519,000 | -886,000 | -261,000 | -1,401,000 | -1,990,000 | -881,000 | -738,000 | -9,000 | -723,000 |
purchases of marketable securities | -64,278,000 | -26,711,000 | -46,920,000 | -40,933,000 | -65,970,000 | -52,714,000 | -57,038,000 | -26,305,000 | -181,386,000 | 0 | -9,578,000 | -17,997,000 | -16,687,000 | -26,464,000 | -5,182,000 | -34,203,000 | -55,327,000 | -28,514,000 | -51,645,000 | -24,376,000 | -132,186,000 | |
maturities of marketable securities | 33,459,000 | 18,795,000 | 28,139,000 | 42,269,000 | 65,439,000 | 28,965,000 | 36,139,000 | 38,336,000 | 1,740,000 | 26,278,000 | 22,566,000 | 35,479,000 | 42,150,000 | 45,825,000 | 57,726,000 | 52,663,000 | 52,077,000 | 25,832,000 | 49,678,000 | 18,680,000 | 3,820,000 | |
sales of marketable securities | 28,648,000 | 9,382,000 | 1,000 | 5,498,000 | 2,970,000 | 8,814,000 | 0 | 0 | 0 | 1,829,000 | 395,000 | 0 | 244,000 | 2,515,000 | ||||||||
net cash from investing activities | -2,392,000 | 982,000 | -37,965,000 | 6,774,000 | 1,458,000 | -16,010,000 | -19,403,000 | 11,174,000 | -179,837,000 | 26,196,000 | 12,821,000 | 17,232,000 | 27,062,000 | 19,237,000 | 51,658,000 | 18,443,000 | -2,136,000 | -235,000 | -2,848,000 | -6,434,000 | -128,375,000 | -45,223,000 |
cash flows from financing activities: | ||||||||||||||||||||||
proceeds from exercise of stock options | 1,311,000 | 3,366,000 | 2,073,000 | 1,972,000 | 588,000 | 3,636,000 | 18,009,000 | 4,283,000 | 10,916,000 | 148,000 | 454,000 | 764,000 | 587,000 | 342,000 | 70,000 | 99,000 | 18,000 | 89,000 | 457,000 | 25,000 | 13,000 | 6,000 |
payment of debt issuance costs | -30,000 | -9,000 | ||||||||||||||||||||
payment of issuance costs from public offering of common stock | -424,000 | |||||||||||||||||||||
proceeds from vendor financing arrangement | 6,786,000 | |||||||||||||||||||||
repayments under vendor financing arrangement | -579,000 | |||||||||||||||||||||
proceeds from issuance of common stock in at-the-market offering, net of issuance costs | 0 | 0 | 0 | 140,653,000 | 0 | 0 | 24,250,000 | 73,621,000 | ||||||||||||||
net cash from financing activities | 7,064,000 | 430,965,000 | 217,327,000 | 100,774,000 | 141,241,000 | 3,636,000 | 18,009,000 | 379,862,000 | 408,388,000 | 147,000 | 454,000 | 24,906,000 | 28,815,000 | 37,203,000 | 70,000 | 99,000 | 18,000 | 89,000 | 457,000 | 25,000 | 157,250,000 | -11,194,000 |
net increase in cash, cash equivalents and restricted cash | -140,250,000 | 320,115,000 | 88,583,000 | 12,845,000 | 36,806,000 | -96,709,000 | -76,023,000 | 336,168,000 | 150,014,000 | 8,969,000 | ||||||||||||
cash, cash equivalents and restricted cash, beginning of period | 895,740,000 | 0 | 0 | 437,391,000 | 0 | 0 | 123,941,000 | 0 | 0 | 174,466,000 | 0 | 0 | 203,519,000 | 0 | 0 | 303,153,000 | ||||||
cash, cash equivalents and restricted cash, end of period | 755,490,000 | 88,583,000 | 12,845,000 | 474,197,000 | -76,023,000 | 336,168,000 | 273,955,000 | -37,327,000 | -13,504,000 | 183,435,000 | 8,923,000 | -12,367,000 | 150,662,000 | -29,343,000 | -52,559,000 | 313,635,000 | ||||||
supplemental disclosures of cash flow information: | ||||||||||||||||||||||
purchase of property and equipment in accounts payable | 77,000 | 335,000 | 29,000 | 27,000 | -15,000 | 17,000 | -29,000 | 39,000 | 63,000 | 167,000 | 41,000 | -222,000 | 324,000 | 59,000 | ||||||||
cash paid for interest | 3,634,000 | 2,515,000 | ||||||||||||||||||||
accretion of discount on marketable securities | ||||||||||||||||||||||
loss on sale of marketable securities | -16,000 | 0 | -8,000 | -6,000 | -9,000 | 0 | 0 | 0 | 23,000 | 4,000 | 9,000 | -9,000 | 30,000 | |||||||||
advance payment for long-lead equipment | 0 | |||||||||||||||||||||
proceeds from issuance of common stock in public offering, net of issuance costs | 378,154,000 | 0 | 0 | 351,329,000 | 323,851,000 | -1,000 | 0 | 24,142,000 | 28,228,000 | |||||||||||||
proceeds from issuance of long-term debt, net of issuance costs paid | 49,454,000 | 0 | ||||||||||||||||||||
cash, cash equivalents and restricted cash, beginning of year | ||||||||||||||||||||||
cash, cash equivalents and restricted cash, end of year | ||||||||||||||||||||||
debt issuance costs included in accounts payable or accrued expenses | ||||||||||||||||||||||
offering costs included in accounts payable or accrued expenses | ||||||||||||||||||||||
proceeds from employee stock option exercise in other receivables | ||||||||||||||||||||||
proceeds from employee stock option exercises in other receivables | ||||||||||||||||||||||
proceeds from issuance of common stock in at-the-market offering in other receivables | 24,250,000 | |||||||||||||||||||||
amortization of premium (discount) on marketable securities | 737,000 | 697,000 | 654,000 | 492,000 | ||||||||||||||||||
public offering costs in accounts payable and accrued expenses | 42,000 | |||||||||||||||||||||
net decrease in cash, cash equivalents and restricted cash | -8,663,000 | -37,327,000 | ||||||||||||||||||||
amortization of premium on marketable securities | -365,000 | -362,000 | -181,000 | 237,000 | 406,000 | 605,000 | ||||||||||||||||
right-of-use assets | 0 | |||||||||||||||||||||
supplemental disclosure of non-cash investing and financing information: | ||||||||||||||||||||||
right-of-use assets acquired under operating leases | 429,000 | |||||||||||||||||||||
proceeds from follow-on public offering of common stock, net of issuance costs | 0 | 0 | 0 | 157,237,000 | ||||||||||||||||||
net decrease in cash and cash equivalents | 8,923,000 | |||||||||||||||||||||
other assets | ||||||||||||||||||||||
net increase in cash and cash equivalents | -52,857,000 | -29,343,000 | -52,559,000 | 10,482,000 | ||||||||||||||||||
amortization of debt discount | ||||||||||||||||||||||
changes in success fee obligation | 0 | |||||||||||||||||||||
proceeds from initial public offering of common stock, net of issuance costs | -1,066,000 | |||||||||||||||||||||
settlement of success fee obligation | 0 | |||||||||||||||||||||
proceeds from issuance of convertible preferred stock, net of issuance costs | -134,000 | |||||||||||||||||||||
proceeds from issuance of debt, net of issuance costs | 0 | |||||||||||||||||||||
repayment of debt | ||||||||||||||||||||||
supplemental cash flow information: | ||||||||||||||||||||||
cash paid for interest and taxes | 17,000 | |||||||||||||||||||||
conversion of convertible preferred stock to common stock | 0 | |||||||||||||||||||||
issuance costs from convertible preferred stock included in accounts payable or accrued expenses | ||||||||||||||||||||||
public offering costs included in accounts payable or accrued expenses | ||||||||||||||||||||||
changes in fair value of preferred stock tranche obligations | ||||||||||||||||||||||
prepaid expenses and other assets | ||||||||||||||||||||||
reclassification of preferred stock tranche obligation liability to permanent equity | ||||||||||||||||||||||
settlement of tranche right i | ||||||||||||||||||||||
cash and cash equivalents at beginning of period | ||||||||||||||||||||||
cash and cash equivalents at end of period |