7Baggers
Quarterly
Annual
    Unit: USD2025-09-30 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-09-30 2017-06-30 2017-03-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2012-12-31 2012-09-30 2012-06-30 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 2009-12-31 2009-09-30 2009-06-30 2008-12-31 2008-09-30 2008-06-30 
      
                                                                
      cash flows from operating activities:
                                                                
      net income
    -3,254,000 -18,677,000 805,000 -77,989,000 -18,895,000 -62,389,000 -13,269,000 -18,355,000 -5,574,000 -9,436,000 -5,316,000 -9,177,000 -13,404,000 -260,086,000 -6,526,000 -5,389,000 -3,527,000 -11,529,540 -11,417,821 -5,802,746 -3,942,893 -947,539 -12,468,547 -2,528,491 -2,386,902 -2,258,264 -2,143,687 -2,470,890 -2,682,760 -1,979,664 -1,860,457 -1,789,211 -2,184,468 -3,934,714 -2,710,184 -2,760,453 -2,425,463 -1,924,264 -1,937,132 -1,407,758 -1,384,759 -2,297,264 -1,441,910 -1,840,331 -1,567,011 -1,552,704 -1,545,807 -2,030,110 -2,053,854 -1,857,017 -1,456,636 -1,509,821 -1,328,804  2,450,669 -7,899,321 363,276 -1,454,081 -1,569,293 -8,222,481 
      adjustments to reconcile net income to net cash from operating activities:
                                                                
      impairment loss
                                                              
      depreciation and amortization
    6,415,000 7,894,000 7,836,000 7,558,000 7,469,000 7,449,000 6,911,000 6,723,000 6,404,000 6,134,000 5,786,000 5,480,000 5,365,000 5,303,000 5,157,000 4,950,000 4,837,000 7,369,913 830,377 844,281 824,429 825,051 792,916 496,690 300,565 264,746 214,000 191,359 187,834 184,075 176,354 131,551 100,770 97,847 72,904 72,298 48,353 45,673 42,712 50,040 50,046 55,140 53,401 79,199 90,331 121,902 95,029 83,160 78,891 69,182 66,599 56,761 52,935 15,009,280,496 38,623 31,363 31,502 21,807 15,923 14,631 
      amortization of debt discount
    294,000 318,000 424,000 597,000 601,000 598,000 645,000 642,000 641,000 651,000 644,000 643,000 643,000 500,000 240,000 232,000 264,000 189,396 187,499   241,630 15,997 15,410 15,383                    8,843 57,558 70,372 136,289 135,271 128,916 121,565 64,173,457,416,569 1,068,978 2,181,878 1,555,691 681,523 540,311 418,275 
      non-cash operating lease expense
    1,267,000 1,379,000 1,565,000 1,466,000 1,360,000 1,700,000 1,122,000 1,182,000 1,099,000                                                    
      unrealized gain on investments in equity securities
                  152,000 -107,000 263,000   -192,163 -144,415   -43,803 -31,545                                    
      realized loss on investments in equity securities
                    285,228 11,597 793,175                                        
      realized loss on available-for-sale investments
     102,000     -7,000    33,000 31,000 49,000                                                
      gain on extinguishment of debt
     -17,326,000                                                          
      gain on divested business
    -3,385,000                                                            
      stock-based compensation expense
    2,526,000 4,413,000 4,838,000 4,997,000 5,456,000 5,848,000 5,976,000 5,800,000 5,184,000 5,333,000 5,366,000 5,258,000 4,125,000 4,182,000 4,148,000 4,025,000 2,990,000 2,561,454 2,432,671 2,301,497 1,620,378 1,610,357 1,945,775 1,991,755 1,413,735  1,498,663 1,445,729 1,049,510 964,857 794,559 770,442 799,797 749,196   637,635 480,377 316,486 210,768 187,358 167,094                   
      loss on disposal of property and equipment
    44,000 89,000 57,000 107,000 131,000 677,000 87,000 113,000 77,000 226,000 270,000 212,000 92,000 417,000 12,000 42,000 71,000 170,108 92,556 40,743 80,593  58,618 52,651 47,603 225,848 109,173 41,861 20,585 26,382 32,602 17,238 7,249 9,123 131,465 4,430                         
      change in credit losses
    109,000 -260,000 36,000 -117,000 99,000  -2,000 -30,000 -103,000                                                    
      excess and obsolete inventory
    146,000         105,000                                                  
      change in contingent consideration
    -1,000 -518,000 412,000 -2,034,000 293,000 -685,000 -137,000 -114,000 46,000                                                    
      changes in operating assets and liabilities:
                                                                
      accounts receivable
    -1,883,000 -3,074,000 -2,633,000 1,121,000 437,000 2,585,000 -16,000 2,518,000 -1,414,000 4,170,000 -4,016,000 -7,631,000 3,340,000 -706,000 -974,000 -377,000 -5,213,000 -1,867,710 -774,772 -929,195 954,677 398,999 -1,401,375 -1,929,567 -664,667 -318,907 389,630 -1,268,700 -760,428 -223,405 215,482 -272,370 -10,326 -1,691 -406,717 84,160 23,825 -171,077 -184,488 621 78,971 28,309 94,986 -248,018 -30,769 -25,602 1,358 -35,442 -20,151 -19,870 23,016 -26,124 48,220  -2,757 282 -5,009 -349 -2,422 19,360 
      inventories
    -421,000 536,000 284,000 1,319,000 1,113,000 3,080,000 -325,000 -2,486,000 1,239,000 -3,025,000 -1,703,000 -1,761,000 -7,715,000 -2,999,000 -1,842,000 -150,000 -988,000 1,324,661 61,754 -73,788 9,373 -123,041 -44,482 -79,348 -6,576 -90,215 -33,009 24,636 -7,130 -17,633 -1,661 18,539 1,353 -13,743 -55,197 26,350 -6,500 -35,124 -2,722 -8,154 -20,203 -8,898 305 13,297 460 -8,413 4,248 2,284 -739 15,639     63,327 17,685 -111,859 -226,309 -73,084 
      prepaid expenses and other current assets
    1,333,000 -2,603,000 1,835,000 -207,000 -1,174,000 2,195,000 -3,549,000 1,522,000 -271,000 -179,000 -376,000 -1,064,000 21,000 334,000 3,234,000 6,033,000 -6,545,000 -7,671,519 -53,684 110,537 94,666 -140,850 -429,138 215,353 10,049    -25,035 44,586 12,490 -34,500                             
      deposits
    -15,000 -1,638,000 204,000 -9,000 -11,000 -455,000 1,000 -198,000 -69,000 -18,000   1,000 -20,000 1,000 229,000 -53,549 -772 -51,678 -46,001 -30,613 683                                      
      operating lease liabilities
    -1,032,000 -1,059,000 -1,527,000 -1,452,000 -1,302,000 -1,586,000 -907,000 -1,098,000 -1,004,000                                                    
      accounts payable and other accrued expenses
    -129,000 2,946,000 -728,000 -2,558,000 264,000 -2,730,000 2,838,000 402,000 -3,276,000 -3,311,000 1,111,000 -2,176,000 -2,107,000 1,936,000 2,649,000 -5,515,000 532,000 -2,120,123 3,215,353 3,084,458 65,312 -697,790 -444,381 1,053,313 659,335 -223,192 -333,521 856,444 105,343 -4,681 -123,881 329,514 72,321 -160,477 -37,317 453,243 144,813 -247,509 54,889 10,381 164,096 -20,228                   
      accrued compensation and related expenses
    1,359,000 2,044,000 438,000 -3,349,000 2,719,000 871,000 1,765,000 -1,714,000 1,962,000 -351,000 363,000 -3,722,000 2,141,000 1,277,000 1,906,000 -1,465,000 804,000 2,491,967 702,567 -819,287 767,753 336,566 32,897 -219,344 491,123 377,357 -18,026 -171,613 149,018 30,468 184,704 -5,413 -8,609 -131,910 168,733 10,191 -55,609 -285,460 108,076 67,977 47,644 47,727 62,850 49,011 23,677 16,577 -107,785 -121,719 128,667 149,729 18,447          
      deferred revenue
    -231,000 44,000 -246,000 -439,000 462,000 -299,000 653,000 -82,000 570,000 -110,000 -269,000 -121,000 -30,000 239,000 -151,000 -35,000 49,000 -178,108 -93,297 -10,878 -26,717 -55,734 201,761 -36,433 -28,397                                    
      net deferred tax liability
    -299,000 6,000   -551,000  30,000 -466,000 246,000                                                    
      net cash from operating activities
    2,188,000 -5,480,000 447,000 -8,025,000 -3,265,000 2,482,000 -1,959,000 -4,054,000 2,774,000 3,654,000 982,000 -7,011,000 524,000 2,614,000 8,876,000 2,627,000 -5,991,000 -9,713,157 -4,843,235 -1,368,968 1,059,360 741,021 -813,395 -1,061,883 -189,603 -359,406 -664,226 -1,265,095 -1,063,653 -965,015 -568,172 -829,923 -1,534,360 -1,449,933 -1,969,641 -1,393,693 -1,068,067 -1,874,289 -1,292,409 -1,060,711 -857,533 -917,049 -1,221,253 -841,575 -1,022,319 -1,231,052 -1,424,817 -1,644,687 -1,546,627 -1,172,205 -1,406,728 -985,026 -1,247,452  -796,196 -639,537 -505,960 -458,440 -889,108 -694,914 
      capex
    -3,453,000 -5,219,000 -4,239,000 -3,790,000 -4,006,000 -11,573,000 -8,969,000 -8,674,000 -9,569,000 -7,857,000 -5,190,000 -4,815,000 -4,245,000 -8,326,000 -8,851,000 -3,894,000 -2,811,000 -3,799,197 -2,576,652 -1,945,992 -596,159 -1,146,898 -1,610,798 -1,457,120 -1,121,025 -1,081,897 -863,049 -699,540 -269,543 -207,350 -391,239 -631,082 -67,340 -193,857 -405,258 -378,591 -225,787 -109,615 -2,279 655 -2,045 -24,386 -2,908 -43,871 -78,329 -44,477 -42,333 -27,988 -60,228 -210,851  
      free cash flows
    -1,265,000 -10,699,000 -3,792,000 -11,815,000 -7,271,000 -9,091,000 -10,928,000 -12,728,000 -6,795,000 -4,203,000 -4,208,000 -11,826,000 -3,721,000 -5,712,000 25,000 -1,267,000 -8,802,000 -13,512,354 -7,419,887 -3,314,960 463,201 -405,877 -2,424,193 -2,519,003 -1,310,628 -1,441,303 -1,527,275 -1,964,635 -1,333,196 -1,172,365 -959,411 -1,461,005 -1,601,700 -1,643,790 -2,374,899 -1,772,284 -1,293,854 -1,983,904 -1,294,688 -1,060,711 -857,533 -917,049 -1,220,598 -843,620 -1,046,705 -1,233,960 -1,468,688 -1,723,016 -1,591,104 -1,214,538 -1,434,716 -1,045,254 -1,458,303  -796,196 -639,537 -505,960 -458,440 -889,108 -694,914 
      ​
                                                                
      cash flows from investing activities:
                                                                
      purchases of property and equipment
    -3,453,000 -5,219,000 -4,239,000 -3,790,000 -4,006,000 -11,573,000 -8,969,000 -8,674,000 -9,569,000 -7,857,000 -5,190,000 -4,815,000 -4,245,000 -8,326,000 -8,851,000 -3,894,000 -2,811,000 -3,799,197 -2,576,652 -1,945,992 -596,159 -1,146,898 -1,610,798 -1,457,120 -1,121,025 -1,081,897 -863,049 -699,540 -269,543 -207,350 -391,239 -631,082 -67,340 -193,857 -405,258 -378,591 -225,787 -109,615 -2,279   655 -2,045 -24,386 -2,908 -43,871 -78,329 -44,477 -42,333 -27,988 -60,228 -210,851        
      software development costs
    -587,000 -125,000 -687,000 -1,631,000 -443,000 -414,000 -2,296,000 -2,071,000 -463,000 -511,000 -401,000 -351,000 -213,000 -113,000 -308,000 -256,000 -193,000                                            
      purchases of short-term investments
     -799,000 -35,884,000 -14,038,000     -8,435,000 -18,742,000 -106,257,000 -30,354,000 -190,427,000 -50,287,000 -26,675,000 -215,318,000 -22,442,805 -41,176 -120,056,684 -16,195,335 -151,034 -37,024,265 -1,010,199 -5,010,461 -8,228                                   
      proceeds from divested business
                                                               
      proceeds from related party loans
                                                                
      acquisitions
                                                                
      sales/maturities of short-term investments
    18,588,000 9,138,000 159,753,000 54,975,000 25,250,000 47,500,000 30,000,000 44,637,000 7,850,000 24,023,000 23,075,000 48,760,000 36,000,000 3,000,000 33,000,000 5,000,000 3,000,000 6,956,756 122,997,378 3,000,000 16,278,866                                        
      patent and trademark costs
    -242,000 -297,000 -163,000 -349,000 -318,000 -255,000 -225,000 -214,000 -177,000 -96,000 -160,000 -220,000 -138,000 -105,000 -41,000 -61,000 -48,000 -83,704 -41,362 -45,080 -29,854 -25,138 -5,441 -22,541 -20,488 -12,398 -7,004 -11,822 -15,350                                
      net cash from investing activities
    14,306,000 3,479,000 153,570,000 13,321,000 6,445,000 -14,760,000 18,510,000 33,678,000 -1,383,000 7,124,000 -5,865,000 -63,990,000 3,050,000 -195,971,000 -27,008,000 -30,905,000 -215,370,000 -383,059,950 120,338,188 -119,047,756 -542,482 789,874 -36,645,504 -21,419,511 -5,651,974 -1,102,523 -10,785,444 -711,362 -284,893 -234,155 -405,768 -641,281 -72,340 -193,857 -405,258 -378,591 -225,787 -109,615 -2,279   655 -2,045 -24,386 -2,908 -43,871 -132,539 -69,814 -70,904 -49,525 -89,789 -255,232  3,884 -6,353 -27,786 54,560 -23,544 -30,132 
      cash flows from financing activities:
                                                                
      proceeds from exercise of stock options
    1,023,000 2,142,000 21,000 9,000 618,000 -2,000 180,000 1,208,000 92,000  999,000                                                  
      repurchase of common stock
    -3,745,000         -4,611,000 -25,000,000 -8,349,000                                                
      cash paid for repurchase of 2026 convertible senior notes
                                                                
      repayment of 2025 convertible senior notes
                                                               
      repayment of notes payable
    -41,000 -28,000 -41,000 -36,000 -36,000 -45,000 -15,000 -21,000 10,000  -1,430,000                        -741,377                       
      repayment of finance lease liabilities
    -105,000 -102,000 -162,000 -74,000 -70,000 -79,000 -53,000 -39,000 -31,000 -36,000   -13,000 -16,000 -12,000 -14,000 -18,000 -18,289 -19,470 -17,942 -14,299 -5,930 -5,835 -5,748 -5,678                                    
      net cash from financing activities
    -2,868,000 2,012,000 -155,291,000 -8,764,000 512,000 -126,000 -24,891,000 1,148,000 71,000 -5,306,000 -459,000 -25,360,000 -8,049,000 288,575,000 2,491,000 1,883,000 271,393,000 266,443,311 2,150,581 114,127,553 2,863,555 1,092,665 1,410,416 70,356,768 1,290,420 24,936,013 5,301,128 2,993,600 5,300,351 3,742,156 -704,394 11,479,535 -360,992 3,376,984 -80,000 -40,000 5,967,644 2,964,637 1,925,952 1,731,290 858,222 717,973 1,370,209 531,121 -37,822 -67,973 -177,280 -325,924 -605,398 7,810,576 421,484 2,723,358 -30,000 6,372,359,235,214 318,862 1,209,726 840,910 -39,000 -58,000 683,713 
      effect of exchange rates on cash and cash equivalents
    -1,231,000 613,000 -519,000 263,000 -375,000 -723,000 499,000 -1,996,000 481,000  -968,000 -1,053,000 -178,000  -1,036,000 1,258,000 -1,411,000  15,511 -7,245 7,251  -8,576 -5,147 -3,982                                    
      net change in cash and cash equivalents
    12,395,000 624,000 -1,793,000 -3,205,000 3,317,000 -13,127,000 -7,841,000 28,776,000 1,943,000 5,871,000 -6,310,000 -97,414,000 -4,653,000 95,421,000 -16,677,000 -25,137,000 48,621,000 -125,114,313 117,661,045 -6,296,416 3,387,684 2,649,616 -36,057,059 47,870,227 -4,555,139 23,477,481 -6,161,493 1,017,143 3,951,805 2,542,986 -1,678,334 10,008,331 -1,733,428.498 1,733,194 -2,454,899 -1,812,284 4,673,790 980,733 631,264     -312,499 -1,084,527 -1,301,933 -1,645,968 -2,103,150 -2,221,839 6,567,467 -1,034,769 1,648,543 -1,532,684 2,982,578 -473,450 563,836 307,164 -442,880 -970,652 -41,333 
      cash and cash equivalents — beginning of period
    46,346,000 36,595,000  139,101,000  36,873,000  47,234,770  37,327,125  15,042,189 4,524,529 2,792,526  1,405,186  369,581                   
      cash and cash equivalents — end of period
    12,395,000 624,000 -1,793,000 -3,205,000 49,663,000 -13,127,000 -7,841,000 28,776,000 38,538,000  -6,310,000 -97,414,000 134,448,000  -16,677,000 -25,137,000 85,494,000  117,661,045 -6,296,416 50,622,454  -36,057,059 47,870,227 32,771,986  -6,161,493 1,017,143 18,993,994 2,542,986 -1,678,334 14,532,860 -1,967,692 4,525,720  -1,812,284 4,673,790 2,385,919  670,579 -67,162 170,505                   
      reconciliation of cash and cash equivalents to the condensed consolidated balance sheets:
                                                                
      cash and cash equivalents from continuing operations
                                                               
      cash and cash equivalents from discontinued operations
                                                               
      total cash and cash equivalents — beginning of period
                                                               
      total cash and cash equivalents — end of period
    12,395,000                                                            
      supplemental disclosure of cash flow information:
                                                                
      cash paid for interest
    4,000 2,064,000 -982,000 1,573,000 38,000 1,607,000 67,000                                                      
      cash paid for income taxes
    308,000 243,000 472,000 290,000 417,000 511,000 -152,000 670,000 433,000                                                    
      supplemental disclosure of non-cash financing activities:
                                                                
      operating lease right-of-use assets and operating lease liabilities
    3,292,000 19,446,000 1,357,000   1,528,000 3,978,000 1,167,000 4,436,000                                                    
      net unrealized gain on available-for-sale debt securities
    163,000 -359,000 1,964,000 994,000 261,000 3,666,000 624,000                                                      
      reclassification of realized gain on available-for-sale debt securities to earnings
    713,000 -400,000 -7,843,000 3,933,000 -2,314,000 -4,397,000           30,000 -15,800 -7,752 26,158 394 1,379 8,963 9,748 3,098                                    
      paid-in-kind preferred stock dividend, including beneficial conversion feature
    2,000,000 2,000,000 2,000,000 2,000,000 2,000,000 2,000,000 2,000,000 2,000,000 2,000,000                                                    
      fixed assets included in accounts payable and accrued liabilities
    -40,000 76,000 -437,000 -78,000 542,000 -130,000 -250,000 115,000 707,000 522,000 84,000 -152,000 549,000 -142,000 -2,314,000 3,670,000 198,000 172,154 -322,568 41,280 608,134 102,402                                       
      contingent consideration reclassed to accounts payable and accrued liabilities
    12,000                                                            
      purchase of equipment through finance lease obligation
    11,000                                                            
      unrealized (gain) loss on investments in equity securities
     2,344,000 -2,471,000 348,000 678,000 -3,563,000 2,360,000 1,405,000 -1,510,000                                                    
      realized gain on available-for-sale investments
                  -8,000 45,000 40,000  6,940 -5,958 -10,934                                        
      gain on insurance settlement
         -2,642,000                                                   
      insurance proceeds for operations
         1,212,000 3,454,000 118,000 3,311,000 3,000,000                                                
      insurance proceeds for loss of fixed assets
         976,000 1,000,000 2,000,000                                                
      cash paid for acquisitions
                                                                
      cash paid for repurchase of 2026 senior notes
                                                               
      intangible assets included in property and equipment
                                                                
      cash paid to repurchase of 2026 senior notes
      -155,109,000                                                          
      realized (gain) loss on available-for-sale investments
       448,000 -2,416,000    86,000                                                    
      net deferred tax asset
                                                                
      goodwill impairment
                                                                
      realized loss on available-for-sale debt securities
                                                                
      (gain) loss on extinguishment of debt
                                                                
      change in expected credit losses
                                                                
      net deferred tax (asset) liability
                                                                
      proceeds from issuance of series c convertible preferred stock, net of issuance costs
                                                                
      proceeds from public offering, net of offering costs
                                                                
      proceeds from issuance of convertible senior notes
                                                              
      purchase of equipment through finance lease obligations
                     484                                          
      common stock issued for conversion of debt and accrued interest
                                                                
      receivable included in prepaid expenses and other current assets
                                                                
      common stock issued for cell&co acquisition
                                                               
      reclassification of realized loss on available-for-sale debt securities to earnings
           -730,000 99,000  -79,000 33,000                                                
      net unrealized (gain) loss on available-for-sale debt securities
            -3,675,000                                                    
      loss on extinguishment of debt
                                                             6,804,311.059 6,902.941 
      realized (gain) loss on available-for-sale debt securities
                                                                
      benefit from bad debt
             221,000 -22,000 4,000 31,000 -237,000 48,000 152,000 63,000 133,021 30,003 30,000 3,976 43   -27,535 32,075   10,000   25,365 7,425 2,503 1,963   2,248                     
      changes in operating assets and liabilities, net of effects of acquisition:
                                                                
      change in operating lease right-of-use assets and lease liabilities
             253,000 289,000 22,000 5,000 259,000 83,000 160,000 60,000 72,938 47,577 6,499 6,986 3,238 5,439 -5,668 -9,309                                    
      proceeds from exercise of stock options and warrants
                313,000 3,009,000 2,503,000 1,897,000 1,586,000 1,076,105 2,418,046 3,015,995 2,877,854 1,078,847 1,412,979 1,555,070 1,315,846 417,952 1,950,823 2,993,600 658,544      10,881 80,978 11,631 146,889                  
      proceeds from issuance of common stock, net of issuance costs
                                                                
      repayment of note payable
                                                             -12,000 
      payment of deferred financing costs
                     495 -247,995    -19,748                    -5,822   -27,500 -130,770  -1,897    -73,180 -73,700 -55,590   -191,875 
      effect of exchange rate changes on cash and cash equivalents
                             3,397                                   
      cash and cash equivalents — beginning of year
                                                                
      cash and cash equivalents — end of year
                                                                
      supplemental disclosure of non-cash investing and financing activities:
                                                                
      unrealized loss on investments in equity securities
              3,880,000 3,648,000 4,908,000         13,824                                       
      contingent consideration
                                                                
      deferred tax (asset) liability
              -488,000                                                  
      mve net working capital settlement
                                                                
      acquisitions, net of cash acquired
                                                                
      proceeds from public offering, net of 17.7 million in offering costs
                  269,825,000                                            
      conversion of series c preferred stock to common stock
                  765,000                                            
      cost of series c preferred stock conversion included in additional paid-in-capital and accounts payable and accrued liabilities
                  1,800,000                                            
      cryopdp goodwill adjustment included in deferred tax liability
                  53,000 -517,000 1,394,000                                            
      cryopdp goodwill adjustment included in fixed assets
                  -1,000 71,000                                            
      fair value adjustment of ctsa contingent consideration included in goodwill and contingent consideration
                                                                
      note valuation adjustment included in notes payable and goodwill
                                                                
      net unrealized loss on available-for-sale securities
              -6,538,000 -33,439,000 14,065,000                                                
      paid-in-kind preferred stock dividend
              2,000,000 2,000,000 2,000,000                                                
      acquisition of cell&co
                                                                
      acquisition of ctsa and f-airgate
                  -21,000                                              
      repayment of capital lease obligation
                                                                
      mve estimated working capital adjustment included in goodwill and accounts payable
                                                                
      deferred tax liability
                60,000  768,000 25,000 80,000  -9,002 27,008 9,002                                        
      mve goodwill adjustment included in fixed assets
                                                                
      note valuation adjustment included in note payable and goodwill
                  9,000 -991,000 1,266,000                                            
      interest expense on convertible note settled by issuance of common stock
                                                                
      accelerated stock-based compensation expense
                         -1,227,890                                       
      proceeds from the issuance of convertible senior notes
                                                                
      fair value adjustment of ctsa contingent consideration included in goodwill and contingent consideration accrual
                                                                
      net unrealized (loss)/gain on available-for-sale securities
                  -366,000                                              
      reclassification of realized (loss)/gain on available-for-sale debt securities to earnings
                  28,000                                              
      purchase of equipment through capital lease obligations
                        202,619                                        
      financing costs included in accounts payable and accrued liabilities
                                                                
      convertible debt costs included in accounts payable and accrued liabilities
                                                                
      net unrealized gain on available-for-sale securities
                    768,000   -135,178 470,924                                        
      unrealized (gain)/loss on investments in equity securities
                                                                
      cash paid for acquisition
                         112,944                                      
      proceeds from june 2019 public offering, net of offering costs
                          3,272                                      
      net unrealized gain/(loss) on available-for-sale securities
                                                                
      realized gain on treasury notes and bills
                         -19,189 -32,573                                      
      warrant inducement and repricing expense
                             899,410                                
      property and equipment disposal costs
                                                                
      accrued interest
                                 -1,843 -2,006 9,018 6,027 -18,988 -1,186 21,524 10,466 7,854 18,110 22,674 8,961 10,364 10,744 -1,483 11,799 12,581 13,444 14,127 14,574 15,011 335,830,007,465 45,826 121,919 156,406 45,235 16,354 118,164 
      maturities of short-term investments
                         2,000,000 1,995,000                                      
      proceeds from issuance of convertible debt
                                              1,352,000 591,000                 
      proceeds from issuance of common stock, net of costs
                                                                
      proceeds from tender offer, net of offering costs
                                                                
      proceeds from the atm, net of offering costs
                                                                
      leasehold improvements paid by tenant allowance
                                                                
      proceeds from february 2018 tender offer, net of offering costs
                             4,641,807                                
      proceeds from atm, net of offering costs
                                                                
      change in net unrealized loss on available-for-sale securities
                                                                
      change in net unrealized gain on available-for-sale securities
                           28,740 30,872                                    
      maturity of short-term investment
                            500,000                                    
      amortization of debt discount and deferred financing costs
                                          220,152 38,140 1,110,013 138,267 25,267                 
      unrealized loss on short-term equity securities
                                                                
      stock-based compensation expense to employees, directors and consultants
                                      826,926                          
      repayment of related-party notes payable
                                 -563,842 -92,379 -128,140 -98,831                           
      deferred offering costs in connection with future warrant repricing included in accounts payable and prepaid expenses and other current assets
                                                                
      amortization of debt discounts and deferred financing costs
                                 6,130 6,266 6,197  65,435 65,435 286,133                       
      prepaid expenses and other assets
                              -379,524                          1,915  -36,210 25,993 3,650 40,727 59,465 29,001 
      proceeds from the public offering, net of offering costs
                                                                
      supplemental disclosure of non-cash investing activities:
                                                                
      unrealized loss on available-for-sale securities
                                                                
      reduction of accounts payable for returned fixed assets
                                                                
      offering costs included in additional paid-in capital and accounts payable and other accrued expenses
                                   165,990                             
      patent costs
                                                                
      proceeds from the april 2016 tender offer, net of offering costs
                                                                
      proceeds from the rights offering, net of offering costs
                                    -186,652 1,185,368                           
      proceeds from the october 2016 tender offer, net of offering costs
                                                                
      cumulative undeclared preferred dividends recorded upon conversion of class a convertible preferred stock and class b convertible preferred stock into common stock
                                                                
      estimated relative fair value of warrants issued in connection with related-party notes payable
                                                                
      leasehold improvements paid by tenant allowance included in accounts payable and accrued expenses
                                                                
      reclassification of shipper inventory to property and equipment
                                                                
      warrant repricing expense
                                    1,929,818                           
      trademark costs
                                 -26,805 -14,529 -10,199                             
      proceeds from the common stock offering, net of offering costs
                                 -165,990 11,571,914                             
      proceeds from april 2016 tender offer, net of offering costs
                                                                
      proceeds from exercise of stock options and warrants, net of costs
                                                                
      cumulative undeclared preferred dividends recorded upon conversion of class a convertible preferred stock and class b convertible preferred stock into common
                                                                
      reclassification of shipper inventory to fixed assets
                                                               
      leasehold improvements paid by tenant allowance included in accounts payable and other accrued expenses
                                                                
      issuance of common stock for accrued board of director compensation
                                                              
      estimated fair value of the beneficial conversion feature on related-party notes payable
                                                                
      other assets
                                    -342,072 -16,022   -66,144 -25,192 55,196 -37,101 5,467 -13,388                   
      acquisition of intangible
                                                                
      proceeds from the tender offer, net of offering costs
                                    -46,200 2,290,447                           
      proceeds from issuance of common stock and warrants in public offering, net of offering costs
                                                               
      proceeds from the issuance of class a and class b convertible preferred stock, net of offering costs
                                                                
      offering costs in connection with the rights offering included in accounts payable and other accrued expenses
                                                                
      purchase of fixed assets included in accounts payable and other accrued expenses
                                                                
      accretion of convertible preferred stock beneficial conversion feature and relative fair value of warrants issued in connection with the convertible preferred stock units to accumulated deficit
                                      4,474,348 1,902,569 492,910 1,727,027 741,786                   
      payment for deferred offering costs
                                         -89,545                       
      offering costs in connection with tender offer included in accounts payable and other accrued expenses
                                     46,200                           
      offering costs in connection with rights offering included in accounts payable and other accrued expenses
                                     184,690                           
      offering costs for future financing included in prepaid expenses and other current assets and accounts payable and other accrued expenses
                                     24,204                           
      deferred offering costs in connection with secondary public offering included in accounts payable and other accrued expenses
                                                                
      estimated relative fair value of beneficial conversion feature on related-party notes payable
                                                                
      loss on write-off of patents
                                                               
      proceeds from the issuance of notes payable
                                                                
      repayment of convertible debt
                                                                
      repayment of offering and deferred financing costs
                                                                
      estimated relative fair value of warrants issued in connection with notes payable
                                          146,257                      
      conversion of convertible debentures payable and accrued interest into convertible preferred stock units
                                          1,766,997                   
      estimated fair value of the beneficial conversion feature on related party notes payable
                                                                
      deposits and other current assets
                                                                
      proceeds from the issuance of preferred stock, net of offering costs
                                       3,896,678  1,140,290 882,222 780,342                   
      repayment of convertible debentures
                                           -50,000                   
      repayment of related party notes payable
                                       -40,000 -60,000 -112,000  -24,000 -24,000 -24,000                   
      offering costs in connection with convertible preferred stock included in accounts payable
                                           9,658                   
      fair value of common stock issued to consultant for future services included in other current assets
                                                                
      loss on disposal of cryogenic shippers
                                          10,650 3,909 179 1,685 10,182 3,075     3,007 897 2,613 13,674       
      benefit from (recovery of) bad debt
                                         3,340                       
      deferred offering costs in connection with secondary public offering included in accounts payable
                                         51,153                       
      change in fair value of derivative instruments
                                              -3 -1,196 6,112 -14,489 -19,335 -14,685 -34,283 227,270 -33,987 -126,345 -116,528        
      debt conversion expense
                                              552,750                 
      deferred financing costs in connection with convertible debt payable included in accounts payable
                                                                
      estimated relative fair value of warrants issued in connection with convertible bridge notes payable
                                                                
      estimated relative fair value of warrants issued in connection with related-party convertible notes payable
                                                                
      conversion of bridge notes payable and accrued interest into common stock units
                                                                
      proceeds from issuance of notes payable
                                                                
      proceeds from issuance of convertible debentures
                                                                
      repayment of offering and deferred costs
                                                                
      estimated relative fair value of warrants issued in connection with convertible debentures payable
                                                                
      conversion of bridge notes payable and accrued interest into shares of common stock and warrants
                                               150,027                 
      net decrease in cash and cash equivalents
                                            -67,162 -199,076                   
      deferred financing costs in connection with convertible debentures payable included in accounts payable
                                                                
      recovery of bad debt
                                             -5,349                   
      loss on write-off of intangible assets
                                                                
      reserve for bad debt
                                                                
      purchases of intangible assets
                                                   -54,210 -25,337 -28,571 -21,537         
      offering costs in connection with equity financing included in accounts payable
                                                -5,822                
      release of restricted cash for repayment of convertible debentures
                                                                
      cash flows from operating activities
                                                                
      fair value of stock options and warrants issued to employees, directors and consultants
                                               178,746                 
      other current assets
                                               -13,271 -18,400 -1,045 28,385 60,893 64,448            
      accounts payable and accrued expenses
                                               350,935 223,125 47,406 30,894 142,752 35,998 50,524           
      cash flows from investing activities
                                                                
      cash flows from financing activities
                                                                
      repayments of convertible debt
                                                                
      payments of offering and deferred financing costs
                                               -115,880                 
      repayments of related party notes payable
                                               -24,000 -32,000 -24,000 -16,000 -24,000 -30,000      -20,000 -30,000 -30,000 -30,000 -30,000 -30,000 
      cash and cash equivalents, beginning of period
                                               4,617,535 9,278,443      249,758 2,231,031 
      cash and cash equivalents, end of period
                                               -312,499 -1,084,527 -1,301,933 2,971,567 -2,103,150 7,056,604      -473,450 563,836 556,922 -442,880 -970,652 2,189,698 
      supplemental disclosure of cash flow information
                                                                
      cash paid during the period for:
                                                                
      interest
                                                3,099 12,577 38,413 50,345 22,727 1,741 12,967 2,133        
      income taxes
                                                  1,600 1,600        
      release of restricted cash for repayment of convertible debentures payable
                                                251,368              
      estimated relative fair value of warrants issued in connection with convertible debt payable
                                                                
      operating activities
                                                                
      interest accrued on restricted cash
                                                   -126 -148 -145 -166 -228 -226        
      investing activities
                                                                
      financing activities
                                                                
      repayments of convertible debentures payable
                                                -82,800 -600,000 -576,628            
      proceeds from exercise of warrants
                                                   324,133 132,000            
      payment on line of credit
                                                                
      proceeds from release of restricted cash
                                                                
      supplemental disclosure of non-cash activities:
                                                                
      cashless exercise of warrants
                                                                
      fair value of stock options and warrants issued to consultants, employees and directors
                                                 168,190 80,836 198,949 171,591    152,067    272,312    
      payment of financing costs
                                                  -78,480             
      cash paid during the year for:
                                                                
      fair value of warrants issued to convertible debenture holders
                                                                
      proceeds from issuance of common stock, net of cash paid for issuance costs
                                                     8,090,745           
      repayment of convertible debentures payable
                                                                
      repayment of deferred financing costs
                                                                
      restricted cash – convertible debenture holder escrow account funds
                                                                
      proceeds from exercise of options and warrants
                                                         14,369,566,207 437,500   3,308 
      cash and cash equivalents, beginning of year
                                                       3,629,886        
      cash and cash equivalents, end of year
                                                       1,648,543 2,097,202        
      proceeds from private placement of common stock, net of cash paid for issuance costs
                                                                
      restricted cash-investor funds
                                                                
      deposits from investors
                                                                
      amortization of deferred financing costs
                                                         15,951,560,528 56,177 17,675 7,904 10,766 10,767 17,162 
      fair value of stock issued to consultants
                                                                
      share-based compensation related to stock options and warrants issued to consultants, employees and directors
                                                     86,305 51,871          
      loss on sale of assets
                                                         8,387 797    
      accrued warranty costs
                                                            -5,625 
      decrease in restricted cash
                                                         10,000,096,759       
      proceeds from borrowings under convertible notes
                                                         13,214,999,801,000      
      repayments of note payable to officer
                                                            -6,000 -18,000 -18,000 
      payment of fees associated with the exercise of warrants
                                                                
      payment of related party notes payable
                                                      -30,000 -30,000 -30,000        
      payment of fees associated with exercise of warrants
                                                          -25,458      
      stock issued to consultants
                                                         166,094,083,008 47,287 12,000 106,807 63,100 77,170 28,500 
      accounts payable
                                                       120,908 -205,513 179,451 -54,265 72,375 102,893 83,131 12,974 1,561 
      inventory
                                                                
      accrued compensation and related expense
                                                        9,293        
      purchases of intangibles
                                                        -44,381        
      accrued expenses
                                                          -97,436 112,278 93 -338 -9,643 9,398 
      repayment of line of credit
                                                                
      offering costs in connection with equity financing
                                                                
      deferred financing costs in connection with convertible debt financing and debt modifications
                                                                
      warrants issued as deferred financing costs in connection with convertible debt financing
                                                                
      purchase of intangible assets with warrants
                                                                
      debt discount in connection with convertible debt financing
                                                                
      conversion of debt and accrued interest to common stock
                                                                
      reclassification of embedded conversion feature to equity upon conversion
                                                                
      cashless exercise of warrants and stock options
                                                                
      cancellation of shares issued for debt principal reduction
                                                                
      change in fair value of warrants issued in connection of debt modification
                                                                
      cumulative effect of accounting change to debt discount for derivative liabilities
                                                                
      cumulative effect of accounting change to accumulated deficit for derivative liabilities
                                                                
      cumulative effect of accounting change to additional paid-in capital for derivative liabilities
                                                                
      reclassification of inventory to property and equipment
                                                                
      fair value of shares issued in connection with debt modifications
                                                                
      addition of principal due to debt modifications
                                                                
      reclassification of derivative liabilities to additional paid in capital upon effectively fixing conversion feature and warrant price
                                                                
      fair value of warrants and options issued to employees and directors
                                                                
      fair value of warrants issued to consultants
                                                                
      change in fair value of derivative instrument
                                                          -4,508,352 4,535,848 -3,134,298    
      interest earned on restricted cash
                                                          -465 -597  -2,276 -2,250 
      accrued salaries and related
                                                          -17,897 23,622 14,928 67,538 -3,871 -4,354 
      purchases of fixed assets
                                                          -8,201 -1 -9,766 -5,235 -23,544 -29,499 
      repayment of convertible notes
                                                             -117,720 
      repayment of borrowings on line of credit
                                                             -3,000 -10,000 -12,500 
      fair value of warrants issued to employees and directors
                                                             -168,244   
      payment of trademark costs
                                                            -18,020  -633 
      net proceeds from borrowings under convertible notes
                                                            926,500 1,062,500 
      decrease (increase) in restricted cash
                                                                
      net proceeds from borrowings under line of credit
                                                                
      proceeds from issuance of common stock
                                                                
      fair value of stock options and warrants issued to employees and directors
                                                               53,887 
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