7Baggers

CytomX Therapeutics, Inc
(NASDAQ:CTMX) 

CTMX stock logo

CytomX Therapeutics, Inc. operates as an oncology-focused biopharmaceutical company in the United States. The company develops antibody therapeutics based on its Probody technology platform for the treatment of cancer. The company's product candidates include CX-2009, an antibody drug conjugates (AD...

Full Time Employees: 158
Sector: Healthcare
Industry: Biotechnology
Pharmaceuticals
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At a glance:
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Quarterly
Annual
    Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 
                                               
      revenues
    		10,258,000 663,000 5,963,000 18,658,000 50,917,000 38,093,000 33,432,000 25,115,000 41,463,000 26,607,000 26,384,000 24,724,000 23,499,000 946,000 16,915,000 18,165,000 17,136,000 19,727,000 17,587,000 16,288,000 15,971,000 16,373,000 17,788,000 16,608,000 49,593,000 8,279,000 10,712,000 9,013,000 29,485,000   21,338,000 14,184,000 28,502,000 23,662,000 8,283,000 11,176,000 5,694,000 2,829,000 2,539,000 1,783,000   
      operating expenses:
    		                                           
      research and development
    		19,238,000 21,235,000 15,304,000 13,322,000 18,868,000 14,790,000 21,368,000 25,172,000 22,052,000 19,386,000 16,448,000 20,671,000 21,175,000 19,564,000 30,367,000 31,159,000 30,559,000 36,579,000 29,143,000 26,100,000 22,371,000 22,007,000 24,049,000 24,066,000 42,814,000 36,441,000 27,967,000 30,835,000 36,376,000 28,306,000 27,549,000 25,553,000 22,458,000 20,704,000 28,920,000 28,076,000 14,576,000 15,348,000 13,337,000 12,705,000 13,365,000 9,503,000 9,157,000 
      general and administrative
    		10,692,000 7,360,000 6,427,000 6,622,000 9,428,000 5,624,000 7,953,000 8,395,000 7,754,000 7,827,000 6,813,000 7,401,000 7,977,000 10,067,000 10,490,000 11,748,000 10,543,000 9,456,000 11,085,000 9,393,000 9,227,000 9,145,000 8,634,000 8,680,000 9,572,000 9,217,000 8,463,000 9,411,000 9,674,000 8,975,000 8,137,000 9,042,000 7,356,000 7,616,000 6,249,000 6,049,000 5,691,000 5,154,000 5,033,000 4,647,000 5,040,000 4,009,000 4,051,000 
      total operating expenses
    		29,930,000 28,595,000 21,731,000 19,944,000 28,296,000 20,414,000 29,321,000 33,567,000 29,806,000 27,213,000 23,261,000 28,072,000 29,152,000 29,631,000 40,857,000 42,907,000 41,102,000 46,035,000 40,228,000 35,493,000 31,598,000 31,152,000 32,683,000 32,746,000 52,386,000 45,658,000 36,430,000 40,246,000 46,050,000 37,281,000 35,686,000 34,595,000 29,814,000 28,320,000 35,169,000 34,125,000 20,267,000 20,502,000 18,370,000 17,352,000 18,405,000 13,512,000 13,208,000 
      income from operations
    		-19,672,000 -27,932,000 -15,768,000 -1,286,000 22,621,000 17,679,000 4,111,000 -8,452,000 11,657,000 -606,000 3,123,000 -3,348,000 -5,653,000 -28,685,000 -23,942,000 -24,742,000 -23,966,000 -26,308,000 -22,641,000 -19,205,000 -15,627,000 -14,779,000 -14,895,000 -16,138,000 -2,793,000 -37,379,000 -25,718,000 -31,233,000 -16,565,000 -25,810,000 -23,177,000 -13,257,000 -15,630,000 -1,247,000 -11,025,000 -25,373,000 -8,614,000 -14,230,000 -14,916,000 -14,258,000 -16,182,000 -11,524,000 -11,269,000 
      yoy
    		-186.96% -258.00% -483.56% -84.78% 94.06% -3017.33% 31.64% 152.45% -306.21% -97.89% -113.04% -86.47% -76.41% 9.04% 5.75% 28.83% 53.36% 78.01% 52.00% 19.00% 459.51% -60.46% -42.08% -48.33% -83.14% 44.82% 10.96% 135.60% 5.98% 1969.77% 110.22% -47.75% 81.45% -91.24% -26.09% 77.96% -46.77% 23.48% 32.36%     
      qoq
    		-29.57% 77.14% 1126.13% -105.68% 27.95% 330.04% -148.64% -172.51% -2023.60% -119.40% -193.28% -40.77% -80.29% 19.81% -3.23% 3.24% -8.90% 16.20% 17.89% 22.90% 5.74% -0.78% -7.70% 477.80% -92.53% 45.34% -17.66% 88.55% -35.82% 11.36% 74.83% -15.18% 1153.41% -88.69% -56.55% 194.56% -39.47% -4.60% 4.61% -11.89% 40.42% 2.26%  
      operating margin %
    		-Infinity% -Infinity% -Infinity% -Infinity% Infinity% Infinity% Infinity% -Infinity% Infinity% -Infinity% Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -214.94% -185.28% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% 
      interest income
    		1,490,000 1,481,000 1,592,000 1,178,000 955,000 1,278,000 1,693,000 1,971,000 2,194,000 2,503,000 2,699,000 2,308,000 2,327,000 732,000 616,000 262,000 68,000 73,000 70,000 44,000 68,000 106,000 200,000 454,000 1,075,000 1,511,000 1,997,000 2,361,000 2,496,000 2,507,000 2,219,000 1,540,000 1,375,000 1,274,000 806,000 357,000 442,000 583,000 692,000 660,000 490,000 441,000 407,000 
      other income
    		-7,000 -5,000 5,000 17,000 11,000 -19,000 -7,000 -2,000 -11,000 9,000 -7,000 -47,000 15,000 1,000 30,000 296,000 13,000 -22,500 -13,000 -82,000 5,000 250 -15,000 5,000 12,000 -31,500 22,000 -88,000  -18,000 29,000 61,000 -140,000 74,000 -47,000 -174,000 120,000 -23,000 45,000 -110,000 19,000 -26,000 -287,000 
      income before income taxes
    		-18,189,000 -26,456,000 -14,171,000 -91,000 23,587,000 18,938,000 5,797,000 -6,483,000 13,840,000 1,906,000 5,815,000       -26,228,000 -22,584,000 -19,243,000 -15,554,000 -14,701,000 -14,710,000 -15,679,000 -1,706,000 -35,877,000 -23,699,000 -28,960,000 -14,130,000               
      provision for income taxes
    		59,000 54,000 58,000 63,000 62,000 62,000 61,000 51,000 49,000 1,069,000 2,823,000               -421,000   -6,000 8,912,000 2,502,000 1,791,000 1,098,000 -520,000 -19,000 26,000      2,000 3,000 
      net income attributable to common stockholders
    		-18,248,000                                     -14,033,000 -14,662,000 -14,176,000 -16,029,000   
      other comprehensive income:
    		                                           
      unrealized loss on investments, net of tax
    		-9,000    -28,000                                       
      total comprehensive income
    		-18,257,000 -26,503,000 -14,158,000 -120,000 23,497,000 18,863,000 5,780,000 -6,528,000 13,686,000                                   
      net income per share
    		                 -0.4 -0.35 -0.3  -0.31 -0.32 -0.34  -0.79 -0.52 -0.64 -0.31 -0.74 -0.53 -0.35 -0.4 0.03 -0.28 -0.69 -0.23 -0.39 -0.4 -0.39 -0.44 24.76 -14.26 
      basic
    		-0.1 -0.22 -0.09  0.27 0.23 0.07 -0.08 0.17 -0.005 0.04          -0.26    0.27                   
      diluted
    		-0.1 -0.22 -0.09  0.27 0.23 0.07 -0.08 0.17 -0.005 0.04          -0.26    0.26                   
      shares used to compute net income per share
    		                                           
      basic
    		177,273,000   129,075,546 87,121,502 434,210 85,093,227 84,880,632 82,029,466 17,806,358.25 80,731,951          60,968,111    45,723,955                   
      diluted
    		177,273,000   129,075,546 87,150,666 316,273 85,204,709 84,880,632 82,630,020 17,806,358.25 80,991,722          60,968,111    47,044,774                   
      net income
    		 -26,510,000 -14,229,000 -154,000 23,525,000 18,876,000 5,736,000 -6,534,000 13,791,000 837,000 2,992,000 -1,087,000 -3,311,000 -27,952,000 -23,296,000 -24,184,000 -23,885,000 -26,228,000 -22,584,000 -19,243,000 -15,554,000 -14,701,000 -14,710,000 -15,679,000 12,205,000 -35,456,000 -23,699,000 -28,960,000 -14,124,000 -32,233,000 -23,431,000 -13,447,000 -15,493,000 621,000 -10,247,000 -25,216,000 -8,257,000 -14,033,000 -14,662,000 -14,176,000 -16,029,000 -11,487,000 -11,870,000 
      yoy
    		 -240.44% -348.06% -97.64% 70.58% 2155.20% 91.71% 501.10% -516.52% -102.99% -112.84% -95.51% -86.14% 6.57% 3.15% 25.68% 53.56% 78.41% 53.53% 22.73% -227.44% -58.54% -37.93% -45.86% -186.41% 10.00% 1.14% 115.36% -8.84% -5290.50% 128.66% -46.67% 87.63% -104.43% -30.11% 77.88% -48.49% 22.16% 23.52%     
      qoq
    		 86.31% 9139.61% -100.65% 24.63% 229.08% -187.79% -147.38% 1547.67% -72.03% -375.25% -67.17% -88.15% 19.99% -3.67% 1.25% -8.93% 16.14% 17.36% 23.72% 5.80% -0.06% -6.18% -228.46% -134.42% 49.61% -18.17% 105.04% -56.18% 37.57% 74.25% -13.21% -2594.85% -106.06% -59.36% 205.39% -41.16% -4.29% 3.43% -11.56% 39.54% -3.23%  
      net income margin %
    		NaN% -Infinity% -Infinity% -Infinity% Infinity% Infinity% Infinity% -Infinity% Infinity% Infinity% Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -268.43% -187.31% -Infinity% -Infinity% Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% 
      unrealized gain on investments, net of tax
    		 19,250 71,000 34,000  -13,750 44,000 6,000 -105,000     -138,250 367,000 -243,000  24.75 37 58                        
      weighted-average common shares used to compute net income per share
    		                                           
      basic
    		 137,935,873 165,004,291                                         
      diluted
    		 137,935,873 165,004,291                                         
      unrealized gain on short term investments, net of tax
    		         -18,250 -98,000 9,000                                
      comprehensive income
    		         -369,750 2,894,000          -15,550    12,484                   
      comprehensive loss
    		           -1,078,000 -3,295,000 -17,979,500 -22,929,000 -24,427,000 -24,562,000 -14,320.5 -22,547 -19,185  -4,572 -14,773 -15,999  -16,644.75 -23,798 -28,824 -13,958 -13,121.25 -23,461 -13,397 -15,627 588 -10,198 -25,226 -8,330 -14,066 -14,734 -14,126 -15,923 -11,555 -11,877 
      net income per share
    		                 -0.4 -0.35 -0.3  -0.31 -0.32 -0.34  -0.79 -0.52 -0.64 -0.31 -0.74 -0.53 -0.35 -0.4 0.03 -0.28 -0.69 -0.23 -0.39 -0.4 -0.39 -0.44 24.76 -14.26 
      basic and diluted net loss per share
    		           -0.02 -0.05 -0.273 -0.35 -0.37 -0.37                           
      shares used in computing basic and diluted net loss per share
    		           66,536,202 66,248,992 16,404,540.5 65,912,334 65,542,762 65,393,691                           
      unrealized gain on short-term investments, net of tax
    		            16,000    -677,000    4  -63 -320 279                   
      other comprehensive loss:
    		                                           
      benefit from income taxes
    		                     -3,477,750   -13,911,000            1,000 -26,000 1,000 3,000 3,000   
      shares used to compute net loss per share, basic and diluted
    		                 387,263 65,208,066 65,055,998  152,777 46,195,121 46,057,063  41,334 45,418,053 45,340,023 45,122,456 1,136,277 43,917,510 38,961,021 38,647,878 9,189,279.75 36,947,129 36,780,897 36,538,869       
      impact of adoption of new accounting pronouncement
    		                            11               
      changes in unrealized gain on short-term investments, net of tax
    		                         -53 -99 136 155               
      other expense
    		                            -61,000               
      revenue
    		                             12,007,750 12,509,000             
      yoy
    		                                           
      qoq
    		                             -4.01%              
      revenue from related party
    		                                           
      total revenue
    		                             12,007,750 12,509,000             
      income before provision for income taxes
    		                             -11,745,000 -20,929,000 -11,656,000 -14,395,000 101,000 -10,266,000 -25,190,000      -5,969,750 -11,867,000 
      changes in unrealized gains on short-term investments
    		                             -28.5 -30 50  -8.5 49 -10 -73       
      total revenues
    		                               21,338,000 14,184,000 27,073,000 24,144,000 8,752,000 11,653,000 6,272,000 3,454,000 3,094,000 2,223,000   
      revenues from related parties
    		                                    477,000 578,000 625,000 555,000 440,000   
      changes in unrealized losses on short-term investments
    		                                -134         -68 -7 
      revenues from related party
    		                                 357,250 482,000 469,000        
      total other comprehensive income
    		                                 -8.5 49 -10 -73       
      interest expense
    		                                    -206,000 -389,000 -482,000 -465,000 -353,000 -376,000 -718,000 
      loss before benefit from income taxes
    		                                    -8,258,000       
      income before benefit from income taxes
    		                                     -14,059,000 -14,661,000 -14,173,000 -16,026,000   
      accretion to redemption value and cumulative dividends on preferred stock
    		                                         -558,000 -2,958,000 
      shares used to compute net income per share attributable to common stockholders, basic and diluted
    		                                     66,706 36,324,805 36,113,363 36,063,425   
      changes in unrealized gains / (losses) on investments
    		                                     20.5 -72     
      total other comprehensive income /
    		                                     20.5 -72     
      changes in unrealized gains / (losses) on short-term investments
    		                                       50 106   
      total other comprehensive gain /
    		                                       50 106   
      revenues:
    		                                         1,988,000 1,939,000 
      net loss attributable to common stockholders
    		                                         -7,508,500 -14,828,000 
      shares used to compute net loss per share attributable to common stockholders, basic and diluted
    		                                         253,133.5 1,039,567 
      total other comprehensive loss
    		                                         -68 -7 
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 
                                                
        assets
      		                                          
        current assets:
      		                                          
        cash and cash equivalents
      		28,828,000 12,667,000 34,185,000 49,041,000 47,604,000 38,052,000 40,576,000 43,247,000 36,185,000 17,171,000 26,024,000 57,536,000 56,357,000 193,650,000 95,036,000 129,290,000 163,488,000 205,530,000 236,284,000 256,146,000 329,666,000 191,859,000 176,810,000 291,388,000 143,286,000 188,425,000 164,646,000 149,392,000 190,407,000 247,577,000 259,753,000 132,908,000 142,155,000 177,548,000 284,225,000 272,860,000 85,662,000 59,758,000 62,379,000 67,897,000 59,822,000 36,191,000 
        short-term investments
      		317,879,000 124,385,000 109,441,000 109,046,000 32,282,000 62,571,000 77,012,000 93,935,000 114,099,000 157,338,000 168,086,000 123,322,000 148,145,000  99,254,000 98,875,000 99,042,000 99,696,000 5,000 10,031,000 64,130,000 124,260,000 144,266,000 55,013,000 104,636,000 107,720,000 161,067,000 199,750,000 206,189,000 188,550,000 204,809,000 202,238,000 219,321,000 196,562,000 47,050,000 63,056,000 76,861,000 118,707,000 133,418,000 112,739,000 126,889,000 77,495,000 
        accounts receivable
      		646,000 2,013,000 1,629,000 1,869,000 1,956,000 3,103,000 3,352,000 2,775,000 13,177,000 3,432,000 2,419,000 1,903,000 1,090,000 35,986,000 1,712,000 1,014,000 1,016,000 790,000 887,000 931,000 756,000 798,000 543,000 206,000 130,010,000 13,000 7,000 10,004,000 44,000 97,000 56,000 25,137,000 81,000 10,139,000 40,183,000 158,000 213,000 240,000 285,000 316,000 744,000 406,000 
        prepaid expenses and other current assets
      		5,743,000 4,856,000 3,962,000 4,665,000 4,786,000 3,579,000 3,240,000 3,123,000 3,786,000 4,995,000 4,675,000 5,040,000 6,685,000 7,466,000 4,278,000 3,591,000 4,898,000 4,285,000 3,822,000 3,897,000 5,456,000 7,096,000 5,625,000 6,898,000 9,073,000 7,177,000 9,058,000 7,531,000 8,437,000 9,251,000 7,890,000 6,388,000 5,474,000 4,352,000 4,848,000 4,579,000 4,118,000 4,401,000 3,411,000 3,438,000 2,299,000 878,000 
        total current assets
      		353,096,000 143,921,000 149,217,000 164,621,000 86,628,000 107,305,000 124,180,000 143,080,000 167,247,000 182,936,000 201,204,000 187,801,000 212,277,000 237,102,000 200,280,000 232,770,000 268,444,000 310,301,000 240,998,000 271,005,000 400,008,000 324,013,000 340,305,000 366,566,000 400,066,000 303,335,000 334,778,000 366,677,000 405,077,000 445,475,000 472,508,000 366,671,000 367,031,000 388,601,000 376,374,000 340,680,000 166,909,000 183,313,000 199,606,000 184,548,000 189,754,000 115,070,000 
        property and equipment
      		1,090,000 1,304,000 1,721,000 1,946,000 2,229,000 2,467,000 2,942,000 3,316,000 3,567,000 3,958,000 4,060,000 4,499,000 4,573,000 5,072,000 5,710,000 5,915,000 6,093,000 5,960,000 6,271,000 6,699,000 7,172,000 6,950,000 7,190,000 7,461,000 7,393,000 7,372,000 7,107,000 7,238,000 7,369,000 6,934,000 5,482,000 5,499,000 4,622,000 4,218,000 4,087,000 4,319,000 4,604,000 3,701,000 3,370,000 3,479,000 3,481,000 3,667,000 
        intangible assets
      		401,000 438,000 474,000 510,000 547,000 583,000 620,000 656,000 693,000 729,000 766,000 802,000 839,000 875,000 911,000 948,000 984,000 1,021,000 1,057,000 1,094,000 1,130,000 1,167,000 1,203,000 1,240,000 1,276,000 1,312,000 1,349,000 1,385,000 1,422,000 1,458,000 1,495,000 1,531,000 1,568,000 1,604,000 1,641,000 1,750,000 1,750,000 1,750,000 1,750,000 1,750,000 1,750,000 1,750,000 
        goodwill
      		949,000 949,000 949,000 949,000 949,000 949,000 949,000 949,000 949,000 949,000 949,000 949,000 949,000 949,000 949,000 949,000 949,000 949,000 949,000 949,000 949,000 949,000 949,000 949,000 949,000 949,000 949,000 949,000 949,000 949,000 949,000 949,000 949,000 949,000 949,000 949,000 949,000 949,000 949,000 949,000 949,000 949,000 
        restricted cash
      		1,527,000 1,527,000 1,028,000 1,028,000 1,028,000 1,027,000 1,027,000 917,000 917,000 917,000 917,000 917,000 917,000 917,000 917,000 917,000 917,000 917,000 917,000 917,000 917,000 917,000 917,000 917,000 917,000 917,000 917,000 917,000 917,000 917,000 917,000 917,000 917,000 917,000 917,000 917,000 917,000 917,000 917,000 917,000  100,000 
        operating lease right-of-use asset
      		2,264,000 3,396,000 4,814,000 5,947,000 7,055,000 8,136,000 9,193,000 10,225,000 11,234,000 12,220,000 13,184,000 14,126,000 15,048,000 15,949,000 16,830,000 17,692,000 18,536,000 19,362,000 20,170,000 20,961,000 21,736,000 22,495,000 23,239,000 23,967,000 24,682,000 25,382,000                 
        other assets
      		31,000 31,000 51,000 56,000 61,000 66,000 70,000 76,000 80,000 83,000 87,000 91,000 27,000 27,000 895,000 895,000 902,000 901,000 902,000 901,000 2,246,000 2,172,000 1,379,000 1,379,000 1,379,000 2,015,000 1,375,000 1,375,000 1,375,000 1,375,000 1,375,000 1,375,000 1,375,000 1,355,000 3,071,000 3,240,000 2,753,000 226,000 268,000 309,000 364,000 3,343,000 
        total assets
      		359,358,000 151,566,000 158,254,000 175,057,000 98,497,000 120,533,000 138,981,000 159,219,000 184,687,000 201,792,000 221,167,000 209,185,000 234,630,000 260,891,000 226,492,000 260,086,000 296,825,000 339,411,000 371,233,000 402,440,000 434,158,000 358,663,000 375,182,000 402,479,000 436,662,000 341,282,000 372,544,000 405,284,000 444,513,000 457,108,000 482,726,000 376,942,000 376,462,000 397,644,000 387,039,000 351,855,000 177,882,000 192,881,000 206,860,000 191,952,000 197,215,000 124,779,000 
        liabilities and stockholders' equity
      		                                          
        current liabilities:
      		                                          
        accounts payable
      		1,368,000 1,301,000 646,000 227,000 276,000 1,088,000 1,422,000 611,000 1,964,000 1,458,000 1,705,000 1,029,000 2,203,000 2,809,000 5,176,000 1,920,000 1,721,000 2,818,000 1,516,000 1,755,000 2,582,000 2,996,000 3,643,000 4,927,000 3,782,000 4,158,000 4,550,000 4,520,000 9,511,000 5,132,000 6,871,000 4,240,000 5,349,000 4,205,000 2,869,000 6,364,000 3,700,000 517,000 1,426,000 4,958,000 4,697,000 2,700,000 
        accrued liabilities
      		11,923,000 14,197,000 12,408,000 11,503,000 11,406,000 12,338,000 16,742,000 13,620,000 14,220,000 17,599,000 20,689,000 20,068,000 22,275,000 28,532,000 31,340,000 31,732,000 31,032,000 34,236,000 25,167,000 19,253,000 18,831,000 23,059,000 23,945,000 21,147,000 28,353,000 30,051,000 20,496,000 22,469,000 22,567,000 26,724,000 21,416,000 24,768,000 16,335,000 16,383,000 11,444,000 7,499,000 6,336,000 9,041,000 7,313,000 4,738,000 4,912,000 5,143,000 
        operating lease liabilities - short-term
      		2,856,000                                          
        deferred revenue, current portion
      		17,876,000 26,877,000 22,379,000 22,050,000 33,226,000  96,063,000 123,766,000 123,628,000  124,396,000 120,280,000 126,784,000  61,325,000 65,787,000 70,013,000  73,089,000 72,369,000 76,636,000  74,445,000 72,711,000 73,866,000  51,080,000 51,684,000 50,765,000  52,997,000 51,512,000 46,988,000          
        total current liabilities
      		34,023,000 46,615,000 41,029,000 39,223,000 50,201,000 85,772,000 119,228,000 142,858,000 144,536,000 155,913,000 146,790,000 141,377,000 151,262,000 152,608,000 97,841,000 99,439,000 102,766,000 106,316,000 99,772,000 93,377,000 98,049,000 100,924,000 102,033,000 98,785,000 106,001,000 85,590,000 76,126,000 78,673,000 96,217,000 97,908,000 86,274,000 83,212,000 69,707,000 61,147,000 71,241,000 60,635,000 37,126,000 23,682,000 22,224,000 17,003,000 15,739,000 13,973,000 
        deferred revenue, net of current portion
      		979,000 1,590,000 5,537,000 10,241,000 16,214,000 26,862,000 33,556,000 36,710,000 59,743,000 80,048,000 112,261,000 140,873,000 157,133,000 180,059,000 85,122,000 95,863,000 108,788,000 125,660,000 140,770,000 158,189,000 169,280,000 186,261,000 202,560,000 221,542,000 236,789,000 178,858,000 187,725,000 197,826,000 197,754,000 225,267,000 236,365,000 250,316,000 255,053,000 264,704,000 267,996,000 237,053,000 65,477,000 79,110,000 82,783,000 61,725,000 54,703,000 56,236,000 
        other long term liabilities
      		4,412,000  4,299,000 4,241,000 4,177,000  4,053,000 3,993,000 3,940,000   216,000                               
        total liabilities
      		39,414,000 52,558,000 50,865,000 55,147,000 73,448,000 120,989,000 162,433,000 190,446,000 216,367,000 249,239,000 272,405,000 294,212,000 321,267,000 346,642,000 198,018,000 211,378,000 228,631,000 250,032,000 259,559,000 271,487,000 288,136,000 308,860,000 327,118,000 343,650,000 366,895,000 290,169,000 290,435,000 303,783,000 321,942,000 326,225,000 325,065,000 335,809,000 326,815,000 327,748,000 341,560,000 299,618,000 104,095,000 103,459,000 105,673,000 79,238,000 71,147,000 71,748,000 
        commitments and contingencies
      		                                          
        stockholders' equity:
      		                                          
        convertible preferred stock
      		                                          
        common stock
      		2,000  2,000 2,000 1,000  1,000 1,000 1,000  1,000 1,000 1,000                              
        additional paid-in capital
      		1,050,037,000 810,844,000 789,720,000 788,083,000 693,103,000 691,095,000 686,962,000 684,967,000 677,986,000 675,905,000 673,109,000 642,214,000 639,526,000 637,117,000 634,357,000 631,662,000 626,721,000 623,344,000 619,117,000 615,849,000 611,733,000 499,964,000 483,524,000 479,516,000 474,455,000 468,285,000 463,773,000 459,367,000 451,613,000 445,956,000 440,616,000 300,627,000 295,744,000 289,454,000 265,625,000 262,185,000 258,509,000 251,748,000 248,777,000 246,256,000 243,687,000  
        accumulated other comprehensive income
      		102,000 111,000 104,000 33,000 -1,000 27,000 40,000 -4,000 -10,000 95,000 -63,000 35,000 26,000 10,000     52,000 15,000  -47,000 -47,000 16,000 336,000 57,000 110,000 209,000 73,000             8,000 
        accumulated deficit
      		-730,197,000 -711,949,000 -682,437,000 -668,208,000 -668,054,000 -691,579,000 -710,455,000 -716,191,000 -709,657,000 -723,448,000 -724,285,000 -727,277,000 -726,190,000 -722,879,000 -605,089,000 -581,793,000 -557,609,000 -533,724,000 -507,496,000 -484,912,000 -465,669,000 -450,115,000 -435,414,000 -420,704,000 -405,025,000 -417,230,000 -381,775,000 -358,076,000 -329,116,000 -314,981,000 -282,748,000 -259,317,000 -245,870,000 -219,465,000 -220,086,000 -209,839,000 -184,623,000 -162,333,000 -147,671,000 -133,495,000 -117,466,000 -105,979,000 
        total stockholders' equity
      		319,944,000 99,008,000 107,389,000 119,910,000 25,049,000         -85,751,000 28,474,000 48,708,000 68,194,000 89,379,000 111,674,000 130,953,000 146,022,000 49,803,000 48,064,000 58,829,000 69,767,000 51,113,000 82,109,000 101,501,000 122,571,000 130,883,000 157,661,000 41,133,000 49,647,000 69,896,000 45,479,000 52,237,000 73,787,000 89,422,000 101,187,000 112,714,000 126,068,000  
        total liabilities and stockholders' equity
      		359,358,000 151,566,000 158,254,000 175,057,000 98,497,000       209,185,000 234,630,000 260,891,000 226,492,000 260,086,000 296,825,000 339,411,000 371,233,000 402,440,000 434,158,000 358,663,000 375,182,000 402,479,000 436,662,000 341,282,000 372,544,000 405,284,000 444,513,000  482,726,000 376,942,000 376,462,000  387,039,000 351,855,000 177,882,000 192,881,000 206,860,000 191,952,000   
        current assets
      		                                          
        current liabilities
      		                                          
        operating lease liabilities - short term
      		 4,240,000 5,596,000 5,443,000 5,293,000 5,145,000 5,001,000 4,861,000 4,724,000 4,589,000                                 
        operating lease liabilities - long term
      		   1,442,000 2,856,000 4,240,000 5,596,000 6,885,000 8,148,000 9,385,000 10,597,000 11,746,000 12,872,000 13,975,000 15,055,000 16,076,000 17,077,000 18,056,000 19,017,000 19,921,000 20,807,000 21,675,000 22,525,000 23,323,000 24,105,000 24,871,000 25,621,000 26,321,000 27,008,000              
        other long-term liabilities
      		 4,353,000    4,115,000    3,893,000 2,757,000               850,000 963,000 963,000 963,000 3,050,000 2,426,000 2,281,000 2,055,000 1,897,000 1,803,000 1,391,000 978,000 154,000 153,000  198,000 244,000 
        stockholders' equity
      		                                          
        convertible preferred stock, 0.00001 par value...
      		                                          
        common stock, 0.00001 par value...
      		 2,000    1,000    1,000    1,000 1,000 1,000 1,000 1,000 1,000 1,000 1,000 1,000 1,000 1,000 1,000 1,000 1,000 1,000 1,000 1,000 1,000 1,000 1,000 1,000 1,000 1,000 1,000 1,000 1,000 1,000 1,000 1,000 
        liabilities and stockholders' deficit
      		                                          
        deferred revenues, current portion
      		     67,201,000    132,267,000    121,267,000    69,262,000    74,869,000    51,381,000    52,713,000    40,559,000 56,928,000 46,772,000 27,090,000 14,124,000 13,485,000 7,307,000 6,130,000 6,130,000 
        stockholders' deficit
      		                                          
        total stockholders' deficit
      		     -456,000 -23,452,000 -31,227,000 -31,680,000 -47,447,000 -51,238,000 -85,027,000 -86,637,000                             -106,048,000 
        total liabilities and stockholders' deficit
      		     120,533,000 138,981,000 159,219,000 184,687,000 201,792,000 221,167,000                                
        stockholders' deficit:
      		                                          
        accumulated other comprehensive loss
      		              -795,000 -1,162,000 -919,000 -242,000   -43,000         -93,000 -208,000 -178,000 -228,000 -94,000 -61,000 -110,000 -100,000    -76,000  
        long-term investments
      		                  99,969,000 99,914,000                  2,025,000     
        income tax receivable
      		                      13,061,000 13,061,000 13,061,000                  
        income tax payable
      		                            13,374,000 13,339,000 4,990,000 2,692,000 1,035,000          
        operating lease right-of-use
      		                          26,069,000 26,743,000 27,404,000              
        liabilities, convertible preferred stock and stockholders' equity
      		                                          
        total liabilities, convertible preferred stock and stockholders' equity
      		                             457,108,000    397,644,000         
        related party accounts receivable
      		                                  68,000 27,000 55,000 207,000 113,000 158,000   
        deferred tax liability
      		                                  520,000 539,000 514,000 513,000 513,000 510,000 507,000 507,000 
        preferred stock, 0.00001 par value...
      		                                          
        stockholders notes receivable
      		                                       -78,000 -78,000 -78,000 
        accumulated other comprehensive income /
      		                                     6,000 80,000 30,000   
        liabilities, redeemable convertible preferred stock, convertible preferred stock and stockholders' equity
      		                                          
        long-term debt, current portion
      		                                          
        long-term debt
      		                                          
        convertible preferred stock warrant liability
      		                                         788,000 
        convertible preferred stock liability
      		                                          
        redeemable convertible preferred stock
      		                                         158,605,000 
        convertible preferred stock, 0.00001 par value – 0 and 244,782 authorized at december 31, 2015 and 2014, respectively; 0 and 244,782 shares issued and outstanding at december 31, 2015 and 2014, respectively
      		                                          
        total liabilities, redeemable convertible preferred stock, convertible preferred stock and stockholders' equity
      		                                        197,215,000  
        liabilities, redeemable convertible preferred stock, convertible preferred stock and stockholders' deficit
      		                                          
        convertible preferred stock, 0.00001 par value – 244,782 authorized at september 30, 2015 and december 31, 2014, respectively; 244,782 shares issued and outstanding at september 30, 2015 and december 31, 2014, respectively
      		                                         474,000 
        total liabilities, redeemable convertible preferred stock, convertible preferred stock and stockholders' deficit
      		                                         124,779,000 
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 
                                                  
          cash flows from operating activities:
        		                                          
          net income
        		-18,248,000 -26,510,000 -14,229,000 -154,000 23,525,000 18,876,000 5,736,000 -6,534,000 13,791,000            -15,554,000    12,205,000             -14,033,000 -14,662,000 -14,176,000 -16,029,000  
          adjustments to reconcile net income to net cash from operating activities:
        		                                          
          amortization of intangible assets
        		37,000 37,000 36,000 37,000 36,000 37,000 36,000 37,000 36,000 37,000 36,000 37,000 36,000 36,000 37,000 36,000 37,000 36,000 37,000 37,000 36,000 37,000 37,000 36,000 36,000 37,000 36,000 37,000 36,000  36,000 37,000 36,000          
          depreciation and amortization
        		214,000 473,000 98,000 310,000 349,000 376,000 393,000 422,000 431,000 449,000 448,000 573,000 559,000 572,000 586,000 574,000 565,000 639,000 643,000 640,000 638,000 625,000 615,000 586,000 601,000 571,000 641,000 630,000 617,000 608,000 474,000 426,000 376,000 404,000 477,000 369,000 395,000 490,000 443,000 445,000 355,000 329,000 
          accretion of discounts on short-term investments
        		-726,000 -719,000 -636,000 -397,000 -454,000 -787,000 -1,220,000 -1,438,000 -1,866,000 -2,226,000 -1,933,000 -1,725,000 -1,535,000                              
          stock-based compensation expense
        		4,706,000 1,479,000 1,384,000 1,431,000 2,008,000 1,884,000 1,995,000 1,882,000 1,907,000 2,552,000 1,226,000 2,371,000 2,409,000 2,570,000 2,695,000 4,490,000 3,370,000 3,544,000 3,164,000 3,425,000 3,034,000 3,419,000 3,841,000 3,513,000 4,013,000 4,111,000 4,343,000 5,454,000 5,192,000 4,616,000 4,413,000 4,161,000 3,688,000 2,750,000 2,780,000 3,010,000 2,747,000 2,622,000 2,720,000 2,391,000 2,362,000 1,921,000 
          non-cash lease expense
        		1,132,000 1,161,000 1,133,000 1,108,000 1,081,000 1,057,000 1,032,000 1,009,000 986,000 964,000 942,000 922,000 901,000 881,000 862,000 844,000 826,000 808,000 791,000 775,000 759,000                      
          changes in operating assets and liabilities
        		                                          
          accounts receivable
        		1,367,000 -384,000 240,000 87,000 1,147,000 249,000 -577,000 10,402,000 -9,745,000 -1,013,000 -516,000 -813,000 34,896,000 -34,210,000 -696,000 -58,000 -232,000 97,000 44,000 -175,000 42,000 -255,000 -337,000 129,804,000 -129,997,000 -6,000 9,997,000 -9,960,000 53,000 -41,000 25,081,000 -25,056,000 10,058,000 -9,956,000 -25,000 55,000 1,946,000 -1,919,000 45,000 31,000 56,000 -338,000 
          prepaid expenses and other assets
        		-887,000 -874,000 708,000 126,000 -1,202,000 -335,000 -111,000 667,000 1,212,000                                  
          accounts payable
        		67,000 655,000 419,000 -49,000 -804,000 -261,000 811,000 -1,428,000 581,000 -328,000 676,000 -1,156,000 -618,000 -2,373,000 3,285,000 216,000 -1,060,000 1,219,000 -185,000 -881,000 -292,000 -587,000 -849,000 527,000 52,000 -526,000 149,000 -5,159,000 5,162,000 -2,534,000 3,224,000 -1,544,000 1,115,000 1,054,000 -3,574,000 2,904,000 -2,825,000 5,824,000 -853,000 -3,452,000 246,000 2,195,000 
          accrued liabilities and other long-term liabilities
        		-3,599,000 486,000 -326,000 -1,103,000 -2,106,000 -5,554,000 2,033,000 -1,673,000 -4,434,000 1,424,000 2,012,000 -3,117,000 -7,360,000  -1,413,000 -302,000 -4,182,000  5,009,000                4,357,000 1,576,000 -1,809,000  1,762,000    
          deferred revenue
        		-9,612,000 551,000 -4,375,000 -17,149,000 -44,623,000 -35,556,000 -30,857,000 -22,895,000 -28,944,000 -24,342,000 -24,496,000 -22,764,000 -17,409,000 65,040,000 -15,203,000 -17,151,000 -16,121,000 -18,938,000 -16,699,000 -15,358,000 -15,214,000 -15,875,000 -17,248,000 -16,402,000 80,416,000 -8,566,000 -10,705,000 991,000 -29,461,000 -11,382,000 -12,466,000 -213,000 -14,134,000 20,339,000 -10,101,000 191,258,000 -11,583,000 10,916,000 -3,034,000 27,236,000 8,199,000 -1,533,000 
          net cash from operating activities
        		-25,549,000 -23,243,000 -15,548,000 -15,753,000 -21,043,000 -19,908,000 -20,729,000 -19,549,000 -26,045,000 -21,963,000 -18,243,000   -1,394,000 -33,844,000 -34,237,000 -41,313,000 -31,192,000 -29,700,000 -28,199,000 -29,940,000 -17,427,000 -24,678,000 97,101,000 -49,737,000 -29,479,000 -23,319,000 -48,653,000 -39,029,000 -28,742,000 -5,551,000 -26,616,000 -14,612,000 22,002,000 -5,738,000 173,195,000 -19,086,000    -5,540,000  
          capital expenditures
        		 -201,000 127,000 -27,000  -80,000 -19,000 -96,000 -115,000 -266,000 -9,000   -182,000 -410,000 -412,000 -736,000 -245,000 -268,000 -114,000 -982,000 -506,000 -1,213,000 -37,000 -1,049,000 -568,000 -747,000 -164,000 -1,590,000 -325,000 -1,643,000 -433,000 -360,000 48,000 -57,000 -324,000 -714,000    -301,000  
          free cash flows
        		 -23,444,000 -15,421,000 -15,780,000  -19,988,000 -20,748,000 -19,645,000 -26,160,000 -22,229,000 -18,252,000   -1,576,000 -34,254,000 -34,649,000 -42,049,000 -31,437,000 -29,968,000 -28,313,000 -30,922,000 -17,933,000 -25,891,000 97,064,000 -50,786,000 -30,047,000 -24,066,000 -48,817,000 -40,619,000 -29,067,000 -7,194,000 -27,049,000 -14,972,000 22,050,000 -5,795,000 172,871,000 -19,800,000    -5,841,000  
          cash flows from investing activities:
        		                                          
          purchases of property and equipment
        		 -201,000 127,000 -27,000 -119,000 -80,000 -19,000 -96,000 -115,000 -266,000 -9,000 -517,000 -48,000 -182,000 -410,000 -412,000 -736,000 -245,000 -268,000 -114,000 -982,000 -445,000 -778,000 -37,000 -1,049,000 -703,000 -628,000 -331,000 -1,835,000 -1,119,000 -1,050,000 -868,000 -751,000 -234,000 -57,000 -324,000 -944,000 -602,000 -863,000 -384,000 -327,000 -182,000 
          purchases of short-term investments
        		-242,777,000  -19,688,000 -108,833,000 -19,785,000  -12,314,000               -10,103,000 -144,298,000 0 -44,707,000 -25,460,000 -47,889,000 -39,326,000 -62,317,000  -62,113,000 -51,498,000 -48,132,000  0 -14,089,000 -40,094,000   -64,096,000 -33,844,000 -121,348,000 
          maturities of short-term investments
        		50,000,000  20,000,000 32,500,000 50,500,000  30,501,000 115,000,000 45,000,000            59,994,000 30,003,000 55,009,000 49,490,000 48,197,000 79,020,000 87,027,000 46,597,000 45,546,000  59,983,000 69,013,000 25,500,000  16,000,000 27,750,000 40,250,000   43,000,000 47,750,000 71,500,000 
          net cash from investing activities
        		-192,777,000 -14,419,000 439,000 -76,360,000 30,596,000 15,135,000 18,168,000 21,512,000 44,885,000 12,866,000 -42,938,000 26,040,000 -146,642,000 99,818,000 -410,000 -412,000 -736,000 -245,000 9,734,000 -46,012,000 59,012,000 19,455,000 -90,067,000 49,453,000 2,441,000 52,857,000 38,510,000 6,940,000 -18,606,000 15,842,000 -3,180,000 16,647,000 -23,383,000 -149,758,000 15,943,000 13,337,000 -788,000     -50,847,000 
          cash flows from financing activities:
        		                                          
          proceeds from issuance of common stock, net issuance cost
        		228,351,000                                          
          proceeds from issuance of pre-funded warrants, net issuance cost
        		5,855,000                                          
          proceeds from exercise of stock options
        		281,000        174,000        7,000    1,023,000    2,157,000    465,000   722,000 2,602,000  1,160,000 666,000 891,000  251,000 130,000 48,000 135,000 
          net cash from financing activities
        		234,487,000 16,643,000 253,000   2,249,000 0 5,099,000 174,000 244,000 29,669,000   190,000 0 451,000 7,000 683,000 104,000 691,000 108,735,000 13,021,000 167,000 1,548,000 2,157,000 401,000 63,000 698,000 465,000 724,000 135,576,000 722,000 2,602,000 21,079,000 1,160,000 666,000 891,000 501,000 251,000 208,000 36,000 82,647,000 
          net increase in cash, cash equivalents and restricted cash
        		16,161,000 -21,019,000 -14,856,000 1,437,000 9,553,000 -2,524,000 -2,561,000 7,062,000 19,014,000     98,614,000 -34,254,000 -34,198,000 -42,042,000 -30,754,000 -19,862,000 -73,520,000 137,807,000     23,779,000     126,845,000            
          cash, cash equivalents and restricted cash, beginning of period
        		14,194,000  0 0 39,079,000  0 0 18,088,000  0 0 194,567,000  0 0 206,447,000  0 0 192,776,000  0 0 189,342,000  0 0 248,494,000  0 0 178,465,000          
          cash, cash equivalents and restricted cash, end of period
        		30,355,000  -14,856,000 1,437,000 48,632,000  -2,561,000 7,062,000 37,102,000  -31,512,000 1,179,000 57,274,000  -34,254,000 -34,198,000 164,405,000  -19,862,000 -73,520,000 330,583,000  -114,578,000 148,102,000 144,203,000  15,254,000 -41,015,000 191,324,000  126,845,000 -9,247,000 143,072,000          
          supplemental disclosures of noncash financing activities:
        		                                          
          common stock issuance costs included in accrued liabilities
        		780,000                                          
          impairment loss on machinery and equipment
        		                                          
          purchases of short term investments
        		         -111,868,000 -92,929,000                                
          maturities of short term investments
        		         125,000,000                                 
          proceeds from issuance of pre-funded warrants and warrants, net of issuance cost
        		         0                                 
          proceeds from issuance of common stock, net of issuance cost
        		                                          
          proceeds from employee stock purchase plan and exercise of stock options
        		         244,000 0   190,000 0   683,000 104,000   1,733,000 167,000   401,000 63,000                
          cash, cash equivalents and restricted cash, beginning of year
        		                                          
          cash, cash equivalents and restricted cash, end of year
        		                                          
          supplemental disclosures of noncash investing items:
        		                                          
          purchases of property and equipment in accounts payable and accrued liabilities
        		                     -61,000 -435,000   135,000 -119,000 167,000 245,000 794,000 -593,000 435,000 391,000 282,000   230,000    26,000 -14,000 
          supplemental disclosures of noncash financing items:
        		                                          
          deemed dividend on warrants
        		                                          
          proceeds from issuance of common stock, net of issuance costs
        		  0    0           0 0 0 107,712,000                      
          proceeds from employee purchase plan and exercise of stock options
        		  253,000    0                                    
          proceeds from issuance of pre-funded warrants and tranche warrants, net of issuance costs
        		                                          
          net loss
        		           -1,087,000 -3,311,000 -27,952,000 -23,296,000 -24,184,000 -23,885,000 -26,228,000 -22,584,000   -14,701,000 -14,710,000   -35,456,000 -23,697,000 -28,961,000 -14,124,000 -32,233,000 -23,431,000 -13,447,000 -15,493,000 621,000 -10,247,000 -25,216,000 -8,257,000      
          adjustments to reconcile net loss to net cash from operating activities:
        		                                          
          prepaid expenses and other current assets
        		         -321,000 366,000 1,645,000 781,000 -3,188,000 -687,000 1,307,000 -613,000 -463,000 75,000 1,559,000 1,640,000   2,175,000 -14,957,000 1,881,000 -1,527,000 906,000 814,000 -1,361,000 -1,660,000 -756,000 -1,122,000 496,000 -269,000 -461,000 -222,000 505,000 -990,000 27,000 -1,139,000 -1,095,000 
          other assets
        		         4,000 4,000   868,000 0 7,000 -1,000 1,000 -1,000 1,345,000 -74,000 -793,000 0 0 636,000     0 0 0 -20,000 1,716,000 169,000 -487,000 220,000 -2,747,000 42,000 41,000 55,000 7,000 
          net decrease in cash, cash equivalents and restricted cash
        		         -8,853,000 -31,512,000 1,179,000 -137,293,000            -45,139,000   -41,015,000 -57,170,000    -35,393,000          
          maturities of investments
        		                 0 10,002,000                   43,000,000     
          net cash from (used) in operating activities
        		            9,349,000                              
          purchase of short-term investments
        		            -146,594,000                              
          amortization of premium (accretion of discounts) on investments
        		             -5,000 -14,000 -16,000 -17,000 -15,000 6,000 140,000 141,000                      
          accrued liabilities, income tax payable and other long-term liabilities
        		                     -3,879,000 2,727,000 -7,272,000 -2,615,000 9,380,000 -2,000,000 -13,499,000 -6,605,000  -751,000 10,158,000 1,145,000          
          purchases of investments
        		                 0 0                   0     
          issuance of common stock in connection with ucsb sublicense fee
        		                                          
          supplemental disclosures of cash flow information:
        		                                          
          cash paid for income taxes
        		                                          
          right of use assets obtained in exchange for operating lease obligations
        		                                          
          accrued and other long-term liabilities
        		                    -5,096,000                      
          accretion of discount on investments
        		                                  55,000 134,000 203,000      
          accretion of discounts on investments
        		                      -27,000 -187,000 -127,000  -556,000 -694,000 -713,000              
          issuance of stock in connection with ucsb sublicense fee
        		                          0                
          prepaid expenses, income tax receivable and other current assets
        		                                          
          supplemental disclosures of noncash investing and financing items:
        		                                          
          amortization of premium (accretion of discount) on investments
        		                                          
          non-cash acquisition of in process research and development asset charged to expense
        		                                          
          deferred income taxes
        		                                 -520,000 -19,000 25,000 1,000 0 0 3,000 3,000 0 
          related party accounts receivable
        		                                 68,000 -41,000 28,000 99,000 53,000 -94,000 45,000 214,000  
          proceeds from common stock issuance, net of issuance costs
        		                                          
          adjustments to reconcile net loss to net cash (used) provided by operating activities:
        		                                          
          loss on disposal of property and equipment
        		                                          
          issuance of common stock in connection with services
        		                                          
          accrued liabilities and other liabilities
        		                                          
          proceeds from sales of assets
        		                                          
          proceeds from employee stock purchases and exercise of stock options
        		                                          
          proceeds from stockholder notes
        		                                      0    
          payment of deferred offering costs
        		                                     0 0 0 -12,000  
          net increase in cash and cash equivalents
        		                                 -106,677,000 11,365,000 187,198,000 -18,983,000    8,075,000  
          gain on disposal of property and equipment
        		                                  0 0 -1,000      
          amortization of premiums (accretion of discounts) on investments
        		                              -471,000 -382,000 -261,000          
          non-cash acquisition of in-process research and development asset charged to expense
        		                                 0         
          proceeds from common stock issuance, net of underwriting discounts and issuance costs of 9,154
        		                                          
          proceeds from exercise of stock options and employee stock purchases
        		                                          
          non-cash adjustment to deferred revenue resulting from the adoption of asc 606
        		                              0            
          non-cash adjustment to deferred revenue resulting from adoption of asc 606
        		                                10,912,000          
          amortization of debt discount
        		                                         0 
          accretion of discount on short-term investments
        		                                       467,000 350,000 370,000 
          change in fair value of convertible preferred stock liability
        		                                         0 
          change in fair value of convertible preferred stock warrant liability
        		                                         0 
          increase in restricted cash
        		                                          
          proceeds from issuance of redeemable convertible preferred stock, net of issuance costs
        		                                         0 
          proceeds from initial public offering, net of issuance costs
        		                                          
          repayment of notes payable
        		                                         -40,000 
          cash and cash equivalents, beginning of year
        		                                          
          cash and cash equivalents, end of year
        		                                          
          accretion to redemption value and cumulative dividends on preferred stock
        		                                         558,000 
          convertible preferred stock liability recorded in connection with redeemable convertible preferred stock
        		                                         0 
          stock issuance costs in accounts payable and accrued liabilities
        		                                          
          issuance of stock in connection with services
        		                                      0 0 159,000  
          cash and cash equivalents, beginning of period
        		                                  0 0 104,645,000  0 0 59,822,000  
          cash and cash equivalents, end of period
        		                                  11,365,000 187,198,000 85,662,000  -2,621,000 -5,518,000 67,897,000  
          adjustments to reconcile net income to net cash (used) provided by operating activities:
        		                                          
          (gain)/loss on disposal of property and equipment
        		                                          
          net cash (used in)/provided by operating activities
        		                                          
          net cash provided by/(used in) investing activities
        		                                          
          proceeds from issuance of common stock under equity incentive plans
        		                                          
          net increase/(decrease) in cash and cash equivalents
        		                                          
          net cash from / (used in) investing activities
        		                                        13,579,000  
          net decrease in cash and cash equivalents
        		                                          
          cash paid for interest
        		                                          
          net change in acquisition of property and equipment in accounts payable and accrued liabilities
        		                                      -89,000    
          issuance costs in accounts payable and accrued liabilities
        		                                          
          deferred offering costs in accounts payable and accrued liabilities
        		                                          
          adjustments to reconcile net income to net cash from / (used in) operating activities:
        		                                          
          net cash from / (used in) operating activities
        		                                          
          net increase / (decrease) in cash and cash equivalents
        		                                          
          accrued liabilities
        		                                        -371,000 1,437,000 
          issuance of common stock in connection with a license agreement
        		                                          
          proceeds from issuance of notes payable
        		                                          
          convertible preferred stock warrants issued in connection with debt