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Cerus Corporation
(NASDAQ:CERS) 

CERS stock logo

Cerus Corporation, a biomedical products company, focuses on developing and commercializing the INTERCEPT Blood System to enhance blood safety. Its INTERCEPT Blood System, a proprietary technology for controlling biological replication is designed to reduce blood-borne pathogens in donated blood com...

Founded: 1991
Full Time Employees: 254
Sector: Healthcare
Industry: Biotechnology

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Quarterly
Annual
    Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 2009-12-31 2009-09-30 2009-06-30 2009-03-31 2008-12-31 2008-09-30 2008-06-30 2008-03-31 2007-12-31 2007-09-30 2007-06-30 2007-03-31 2006-12-31 2006-09-30 2006-06-30 2006-03-31 2005-12-31 2005-09-30 2005-06-30 2005-03-31 2004-12-31 2004-09-30 2004-06-30 2004-03-31 2003-09-30 2003-06-30 2003-03-31 2002-09-30 2002-06-30 2002-03-31 2001-09-30 2001-06-30 2001-03-31 
                                                                                                      
      product revenue
    53,661,000 57,751,000 52,698,000 52,445,000 43,239,000 50,809,000 46,017,000 45,079,000 38,365,000 46,768,000 39,772,000 38,853,000 30,974,000 44,034,000 39,571,000 40,999,000 37,444,000 39,865,000 36,131,000 31,484,000 23,379,000 28,199,000 23,607,000 21,503,000 18,611,000 20,917,000 18,019,000 18,209,000 17,504,000 16,525,000 15,399,000 15,420,000 13,564,000 16,240,000 10,797,000 9,525,000 7,006,000 10,125,000 10,175,000          7,866,000 9,232,000 10,542,000 10,150,000 9,733,000 10,528,000 8,252,000 9,224,000 8,691,000 9,896,000 7,770,000 6,753,000 6,183,000 5,965,000 4,521,000 5,690,000 5,500,000 5,228,000 4,567,000 3,871,000 3,085,000 3,541,000 3,095,000 4,030,000 4,852,000 2,395,000 2,762,000 1,671,000 1,187,000 926,000 794,000 776,000 479,000                  
      cost of product revenue
    25,767,000 28,002,000 24,558,000 23,470,000 17,815,000 23,424,000 19,818,000 20,413,000 17,093,000 20,809,000 17,956,000 17,515,000 13,687,000 19,498,000 17,662,000 19,718,000 18,076,000 19,475,000 17,582,000 15,323,000 11,095,000 12,179,000 10,953,000 9,705,000 8,320,000 9,293,000 7,583,000 8,111,000 8,432,000 8,442,000 8,142,000 7,720,000 7,330,000 9,129,000 5,348,000 4,360,000 3,694,000 5,605,000 5,451,000          4,157,000 4,939,000 6,826,000 5,747,000 5,090,000 5,117,000 4,411,000 5,574,000 5,514,000 6,462,000 4,650,000 3,978,000 3,445,000 3,630,000 2,324,000 2,934,000 3,158,000 3,724,000 4,242,000 2,520,000 2,094,000 2,964,000 1,913,000 3,077,000 1,714,000 1,664,000 1,673,000 1,067,000 824,000 705,000 373,000 281,000 182,000                  
      gross profit on product revenue
    27,894,000 29,749,000 28,140,000 28,975,000 25,424,000 27,385,000 26,199,000 24,666,000 21,272,000 25,959,000 21,816,000 21,338,000 17,287,000 24,536,000 21,909,000 21,281,000 19,368,000 20,390,000 18,549,000 16,161,000 12,284,000 16,020,000 12,654,000 11,798,000 10,291,000 11,624,000 10,436,000 10,098,000 9,072,000 8,083,000 7,257,000 7,700,000 6,234,000 7,111,000 5,449,000 5,165,000 3,312,000 4,520,000 4,724,000          3,709,000 4,293,000 3,716,000 4,403,000 4,643,000                                              
      government contract revenue
    6,232,000 6,828,000 7,539,000 7,684,000 5,614,000 5,942,000 4,639,000 5,440,000 5,030,000 6,574,000 7,479,000 8,875,000 7,502,000 7,287,000 6,772,000 6,632,000 5,576,000 10,223,000 5,970,000 6,279,000 6,187,000 5,391,000 5,584,000 5,324,000 6,030,000 5,571,000 4,827,000 4,266,000 4,461,000 3,713,000 3,928,000 4,047,000 3,455,000                                                                  
      operating expenses:
                                                                                                      
      research and development
    14,532,000 16,390,000 15,825,000 18,900,000 16,605,000 15,443,000 14,013,000 14,969,000 14,482,000 14,288,000 16,783,000 19,184,000 17,384,000 18,614,000 16,220,000 15,216,000 14,057,000 15,572,000 15,288,000 17,083,000 15,748,000 17,061,000 15,921,000 15,618,000 15,810,000 16,438,000 16,081,000 14,417,000 13,440,000 12,421,000 10,825,000 9,881,000 9,437,000 7,783,000 7,886,000 8,891,000 9,150,000 8,815,000 7,033,000 8,557,000 6,917,000 7,160,000 7,689,000 5,213,000 5,581,000 5,186,000 7,250,000 4,722,000 4,642,000 4,618,000 4,363,000 3,506,000 2,700,000 2,164,000 1,903,000 1,712,000 1,824,000 1,562,000 1,814,000 1,994,000 1,808,000 1,419,000 1,282,000 1,244,000 1,250,000 1,505,000 1,230,000 1,625,000 2,012,000 2,268,000 2,483,000 2,670,000 3,076,000 -5,129,000 6,881,000 6,757,000 6,448,000 7,438,000 7,030,000 8,357,000 6,682,000 6,578,000 6,626,000 5,881,000 5,049,000 5,073,000 5,190,000 8,720,000 8,668,000 13,400,000 14,752,000 14,695,000 14,881,000 14,484,000 11,921,000 12,194,000 12,086,000 11,318,000 
      selling, general and administrative
    19,948,000 20,828,000 18,618,000 21,182,000 20,286,000 19,333,000 17,786,000 18,973,000 19,799,000 17,269,000 16,155,000 20,541,000 21,551,000 23,160,000 19,908,000 19,532,000 20,735,000 22,003,000 20,357,000 19,758,000 19,170,000 18,691,000 16,299,000 16,112,000 15,913,000 17,164,000 16,140,000 16,740,000 16,161,000 14,833,000 13,964,000 14,437,000 13,607,000 12,506,000 12,180,000 14,094,000 13,633,000 12,439,000 12,161,000 12,406,000 11,747,000 11,276,000 10,932,000 12,063,000 11,718,000 10,689,000 8,724,000 10,080,000 8,236,000 7,430,000 7,728,000 7,954,000 6,853,000 6,794,000 6,219,000 6,686,000 5,966,000 5,938,000 5,380,000 6,207,000 5,528,000 3,916,000 5,089,000 5,304,000 5,270,000 4,212,500 5,340,000 5,409,000 6,101,000 5,401,750 7,067,000 7,439,000 6,809,000 4,276,000 5,631,000 6,151,000 5,322,000 2,537,750 3,273,000 3,762,000 3,116,000                  
      total operating expenses
    34,480,000 37,218,000 34,443,000 40,082,000 36,891,000 34,776,000 31,799,000 33,942,000 34,281,000 31,557,000 34,538,000 41,853,000 38,935,000 41,774,000 36,128,000 34,748,000 34,792,000 37,575,000 35,645,000 36,841,000 34,918,000 35,752,000 32,220,000 31,730,000 31,723,000 33,602,000 32,221,000 31,157,000 29,601,000 27,254,000 24,789,000 24,318,000 23,044,000 20,340,000 20,116,000 23,036,000 22,833,000 21,455,000 19,244,000 21,014,000 18,714,000 18,487,000 18,671,000 17,327,000 17,349,000 15,926,000 16,024,000 14,853,000 12,928,000 12,099,000 12,141,000 11,511,000 9,603,000 9,009,000 8,172,000 8,449,000 7,840,000 7,550,000 7,245,000 8,252,000 7,386,000 7,581,000 6,371,000 6,548,000 6,520,000 6,662,000 6,585,000 7,163,000 8,825,000 7,825,000 9,550,000 10,109,000 9,885,000 -1,222,000 14,185,000 23,425,000 12,594,000 12,004,000 10,676,000 12,400,000 9,980,000 8,958,000 8,787,000 8,497,000 7,470,000 7,347,000 7,575,000 14,104,000 11,711,000 15,987,000 17,575,000 17,390,000 17,806,000 17,508,000 14,723,000 14,541,000 14,744,000 13,697,000 
      income from operations
    -354,000 -641,000 1,236,000 -3,423,000 -5,853,000 -1,449,000 -961,000 -3,836,000 -7,979,000 976,000 -5,243,000 -11,640,000 -14,146,000 -9,951,000 -7,447,000 -6,835,000 -9,848,000 -6,962,000 -11,126,000 -14,401,000 -16,447,000 -14,341,000 -13,982,000 -14,608,000 -15,402,000 -16,407,000 -16,958,000 -16,793,000 -16,068,000 -15,458,000 -13,604,000 -12,571,000 -13,355,000 -10,851,000 -12,382,000 -16,204,000 -18,093,000 -15,104,000 -14,259,000 -16,739,000 -15,345,000 -14,993,000 -16,186,000 -15,525,000 -14,371,000 -12,929,000 -11,351,000 -11,004,000 -9,219,000 -7,806,000 -8,425,000 -7,108,000 -4,960,000 -3,598,000 -4,331,000 -4,799,000 -4,572,000 -3,589,000 -2,646,000 -5,477,000 -4,212,000 -4,750,000 -3,704,000 -3,547,000 -3,956,000 -4,912,000 -6,013,000 -5,477,000 -7,431,000 -7,163,000 -7,581,000 -9,156,000 -6,630,000 -5,874,000 -10,485,000 -18,911,000 -7,896,000 2,145,000 -2,702,000 -5,940,000 -2,983,000                 -12,253,000 
      yoy
    -93.95% -55.76% -228.62% -10.77% -26.64% -248.46% -81.67% -67.04% -43.60% -109.81% -29.60% 70.30% 43.64% 42.93% -33.07% -52.54% -40.12% -51.45% -20.43% -1.42% 6.78% -12.59% -17.55% -13.01% -4.14% 6.14% 24.65% 33.59% 20.31% 42.46% 9.87% -22.42% -26.19% -28.16% -13.16% -3.20% 17.91% 0.74% -11.91% 7.82% 6.78% 15.96% 42.60% 41.09% 55.88% 65.63% 34.73% 54.81% 85.87% 116.95% 94.53% 48.11% 8.49% 0.25% 63.68% -12.38% 8.55% -24.44% -28.56% 54.41% 6.47% -3.30% -38.40% -35.24% -46.76% -31.43% -20.68% -40.18% 12.08% 21.94% -27.70% -51.58% -16.03% -373.85% 288.05% 218.37% 164.70%                      
      qoq
    -44.77% -151.86% -136.11% -41.52% 303.93% 50.78% -74.95% -51.92% -917.52% -118.62% -54.96% -17.72% 42.16% 33.62% 8.95% -30.60% 41.45% -37.43% -22.74% -12.44% 14.69% 2.57% -4.29% -5.16% -6.13% -3.25% 0.98% 4.51% 3.95% 13.63% 8.22% -5.87% 23.08% -12.36% -23.59% -10.44% 19.79% 5.93% -14.82% 9.08% 2.35% -7.37% 4.26% 8.03% 11.15% 13.90% 3.15% 19.36% 18.10% -7.35% 18.53% 43.31% 37.85% -16.92% -9.75% 4.97% 27.39% 35.64% -51.69% 30.03% -11.33% 28.24% 4.43% -10.34% -19.46% -18.31% 9.79% -26.30% 3.74% -5.51% -17.20% 38.10% 12.87% -43.98% -44.56% 139.50% -468.11% -179.39% -54.51% 99.13%                   
      operating margin %
    -Infinity% -Infinity% Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -180.94% -201.06% -155.27% -201.19% -175.82% -186.83% -192.76% -109.54% -127.94% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% Infinity% -Infinity% -Infinity% -Infinity% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% -Infinity% 
      non-operating expense, net:
                                                                                                      
      foreign exchange gain
    150,000   -911,000 -287,000 543,000 -241,000 -77,000 145,000 5,500 166,000 49,000  -622,000 234,000 -104,000  -130,000 -164,000 118,000  253,000 490,000 273,000  -77,750 -254,000 105,000 -162,000 -65,000 8,000  108,000   -14,000    101,000    499,000 -1,113,000 -351,000 -941,000  21,000 335,000 409,000  -54,000 298,000 206,000 -748,000 330,000 100,000 -39,000 -258,000 697,000 -570,000 827,000 -975,000                                   
      interest expense
    -1,872,000 -1,964,000 -2,119,000 -2,150,000 -2,110,000 -2,053,000 -2,260,000 -2,330,000 -2,234,000 -2,229,000 -2,364,000 -2,181,000 -1,612,000 -1,697,000 -1,406,000 -1,348,000 -1,380,000 -1,334,000 -1,279,000 -1,338,000 -972,000 -952,000 -930,000 -929,000 -935,000 -960,000 -1,031,000 -1,150,000 -2,924,000 -1,082,000 -1,053,000 -958,000 -915,000 -900,000 -1,090,000 -501,000 -531,000 -546,000 -586,000 -658,000 -655,000 -644,000 -505,000 -301,000 -255,000 77,000 -342,000 -141,000 -193,000 -241,000 -41,000 -107,000 -131,000 -141,000 -136,000 -135,000 -139,000 -117,000 -394,000 -220,000 -233,000 -231,000 -226,000                                    
      other income
    519,000 589,000 976,000 845,000 606,000 508,000 604,000 412,000 452,000 606,000 233,000 539,000 387,000 -1,088,000 165,000 -30,000 -782,000 -624,000 205,000 337,000 456,000 751,000 351,000 460,000 151,000 301,000 336,000 337,000 422,000 460,000 513,000 444,000 331,000 142,000 104,000 3,512,000 106,000 847,000 114,000 113,000 66,000 35,000 7,000 27,000 2,000 -319,000 145,000 134,000 170,000 201,000 32,000 16,000 17,000 -6,000 -72,000 101,000 8,000    16,000 546,000 -8,000 -252,000 -1,066,000 -81,250 376,000 -735,000                               
      total non-operating expense
    -1,203,000 -1,424,000 -1,171,000 -2,216,000 -1,791,000 -1,002,000 -1,897,000 -1,995,000 -1,637,000 -2,293,000 -1,965,000 -1,593,000 -1,418,000 -3,407,000 -1,007,000 -1,482,000 -2,360,000 -2,088,000 -1,238,000 -883,000 -912,000 52,000 -89,000 -196,000 -1,007,000 -1,080,250 -949,000 -708,000 -2,664,000    -476,000    -470,000                -5,241,000    -4,262,000   -836,000 -798,000                                      
      income before income taxes
    -1,557,000 -2,065,000 65,000 -5,639,000 -7,644,000 -2,451,000 -2,858,000 -5,831,000 -9,616,000 -1,317,000 -7,208,000 -13,233,000 -15,564,000 -13,358,000 -8,454,000 -8,317,000 -12,208,000 -9,050,000 -12,364,000 -15,284,000 -17,359,000 -14,289,000 -14,071,000 -14,804,000 -16,409,000 -16,841,000 -17,907,000 -17,501,000 -18,732,000 -16,145,000 -14,136,000 -13,223,000 -13,831,000 -11,560,000 -13,368,000 -13,207,000 -18,563,000 -14,705,000 -14,792,000 -17,183,000 -16,051,000 -16,506,000 -15,585,000 -18,007,000 -9,441,000 -20,077,000 -10,751,000 -7,545,000 -187,000 -5,807,000 -20,441,000 -6,670,000 -10,201,000                                              
      provision for income taxes
    91,000 119,000 85,000 76,000 74,000 111,000 76,000 -56,000 74,000 72,000 78,000 98,000 77,000 267,000 67,000 78,000 76,000 71,000 73,000 77,000 98,000 92,000 68,000 67,000 57,000 82,000 60,000 61,000 60,000 60,000 56,000 59,000 54,000 -74,000 50,000 3,876,000 35,000 -1,204,000 -416,000 983,000 812,000 -1,750,000 95,000 -2,035,000 19,000 105,000 8,000 44,000 38,000 53,000 60,000 54,000 51,000                                             -100,000 
      net income
    -1,648,000 -2,184,000 -20,000 -5,715,000 -7,718,000 -2,562,000 -2,934,000 -5,775,000 -9,690,000 -1,389,000 -7,286,000 -13,331,000 -15,641,000 -13,625,000 -8,521,000 -8,395,000 -12,284,000 -9,121,000 -12,437,000 -15,361,000 -17,457,000 -14,381,000 -14,139,000 -14,871,000 -16,466,000 -16,923,000 -17,967,000 -17,562,000 -18,792,000 -16,205,000 -14,192,000 -13,282,000 -13,885,000 -11,486,000 -13,418,000 -17,083,000 -18,598,000 -13,501,000 -14,376,000 -18,166,000 -16,863,000 -14,756,000 -15,680,000 -15,972,000 -9,460,000 -20,182,000 -10,759,000 -7,589,000 -225,000 -5,860,000 -20,501,000 -6,724,000 -10,252,000 -1,716,000 -3,460,000 -1,907,000 -8,834,000 -7,997,000 2,338,000 -6,313,000 -5,010,000 -2,630,000 -3,832,000 -5,427,000 -5,022,000 -4,889,000 -5,637,000 -6,212,000 -7,397,000 -5,978,000 -8,818,000 -9,093,000 -5,292,000 -11,430,000 -9,151,000 -17,915,000 -6,808,000 3,010,000 -1,787,000 -5,072,000 -930,000 -3,894,000 -1,666,000 -2,761,000 21,385,000 -5,352,000 -5,060,000 -11,547,000 -9,194,000 -14,208,000 -16,772,000 -17,159,000 -16,591,000 -11,284,000 -13,547,000 -12,726,000 -11,975,000 -11,165,000 
      yoy
    -78.65% -14.75% -99.32% -1.04% -20.35% 84.45% -59.73% -56.68% -38.05% -89.81% -14.49% 58.80% 27.33% 49.38% -31.49% -45.35% -29.63% -36.58% -12.04% 3.30% 6.02% -15.02% -21.31% -15.32% -12.38% 4.43% 26.60% 32.22% 35.34% 41.08% 5.77% -22.25% -25.34% -14.92% -6.66% -5.96% 10.29% -8.51% -8.32% 13.74% 78.26% -26.89% 45.74% 110.46% 4104.44% 244.40% -47.52% 12.86% -97.81% 241.49% 492.51% 252.60% 16.05% -78.54% -247.99% -69.79% 76.33% 204.07% -161.01% 16.33% -0.24% -46.21% -32.02% -12.64% -32.11% -18.22% -36.07% -31.68% 39.78% -47.70% -3.64% -49.24% -22.27% -479.73% 412.09% 253.21% 632.04% -177.30% 7.26% 83.70% -104.35% -27.24% -67.08% -76.09% -332.60% -62.33% -69.83% -32.71% -44.58% 25.91% 23.81% 34.83% 38.55% 1.07%     
      qoq
    -24.54% 10820.00% -99.65% -25.95% 201.25% -12.68% -49.19% -40.40% 597.62% -80.94% -45.35% -14.77% 14.80% 59.90% 1.50% -31.66% 34.68% -26.66% -19.04% -12.01% 21.39% 1.71% -4.92% -9.69% -2.70% -5.81% 2.31% -6.55% 15.96% 14.18% 6.85% -4.34% 20.89% -14.40% -21.45% -8.15% 37.75% -6.09% -20.86% 7.73% 14.28% -5.89% -1.83% 68.84% -53.13% 87.58% 41.77% 3272.89% -96.16% -71.42% 204.89% -34.41% 497.44% -50.40% 81.44% -78.41% 10.47% -442.04% -137.03% 26.01% 90.49% -31.37% -29.39% 8.06% 2.72% -13.27% -9.26% -16.02% 23.74% -32.21% -3.02% 71.83% -53.70% 24.90% -48.92% 163.15% -326.18% -268.44% -64.77% 445.38% -76.12% 133.73% -39.66% -112.91% -499.57% 5.77% -56.18% 25.59% -35.29% -15.29% -2.26% 3.42% 47.03% -16.70% 6.45% 6.27% 7.25%  
      net income margin %
    -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -196.37% -220.95% -152.82% -194.90% -180.88% -122.98% -300.90% -103.83% -88.23% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% 
      net loss attributable to noncontrolling interest
    -8,000  -1,000 -8,000 -1,000 -41,000   -2,000 -61,000 -19,000 -56,000 -22,000 -1,000 -39,000 -6,000                                                                                   
      net loss attributable to cerus corporation
    -1,640,000 -2,184,000 -19,000 -5,707,000 -7,717,000 -2,521,000 -2,934,000 -5,775,000 -9,688,000 -1,328,000 -7,267,000 -13,275,000 -15,619,000 -13,624,000 -8,482,000 -8,389,000 -12,284,000 -9,119,000 -12,437,000                                                                                
      net income per share
                                                                -0.11 -0.093 -0.1 -0.14 -0.13 -0.145 -0.16 -0.19 -0.23 -0.18 -0.27 -0.28 -0.16            0.96 -0.24 -0.23 -0.52 -0.42 -0.64 -0.97 -1.07 -1.05 -0.71 -0.86 -0.81 -0.8 -0.79 
      basic and diluted
    -0.01 -0.01  -0.03 -0.04 -0.01 -0.02 -0.03 -0.05 -0.01 -0.04 -0.07 -0.09 -0.07 -0.05 -0.05 -0.07 -0.05 -0.07 -0.09 -0.1 -0.09 -0.08 -0.09 -0.1 -0.12 -0.13 -0.13                                                                       
      weighted-average shares outstanding:
                                                                                                      
      basic and diluted
    194,142 190,594 191,830 191,301 187,066 184,563 185,424 184,982 182,090 180,270 180,938 180,611 178,273 176,545 177,236 176,944 174,478 171,279 171,904 171,240 168,824 163,949 166,572 164,383 157,405 139,831 140,908 138,281                                       35,000 32,650                               
      foreign exchange loss
     -306,500 -28,000          -193,000    -198,000    -396,000    -223,000       -138,000  -14,750   -45,000 -19,250 -61,000  -117,000 -156,000 -10,000     -25,000    -157,000                                               
      restructuring
              1,600,000 2,128,000                                                      -15,000 15,000 129,000 712,000                  396,000 2,465,000           
      weighted-average shares used for eps calculation
                                                                                                      
      basic and diluted
    194,142 190,594 191,830 191,301 187,066 184,563 185,424 184,982 182,090 180,270 180,938 180,611 178,273 176,545 177,236 176,944 174,478 171,279 171,904 171,240 168,824 163,949 166,572 164,383 157,405 139,831 140,908 138,281                                       35,000 32,650                               
      net income per share
                                                                -0.11 -0.093 -0.1 -0.14 -0.13 -0.145 -0.16 -0.19 -0.23 -0.18 -0.27 -0.28 -0.16            0.96 -0.24 -0.23 -0.52 -0.42 -0.64 -0.97 -1.07 -1.05 -0.71 -0.86 -0.81 -0.8 -0.79 
      basic
                                -0.14 -0.12 -0.11 -0.1 -0.11 -0.1 -0.12 -0.16 -0.18 -0.13 -0.14 -0.18 -0.17 -0.15 -0.16 -0.17 -0.1 -0.27 -0.14 -0.1      -65 -60   -47.5 50                  -210 120 -60 -180 -40                  
      diluted
                                -0.14 -0.12 -0.11 -0.1 -0.11 -0.1 -0.12 -0.16 -0.18 -0.13 -0.14 -0.18 -0.17 -0.13 -0.17 -0.17 -0.17 -0.17 -0.16 -0.16 -0.12     -65 -80   -47.5 50                  -210 120 -60 -180 -40                  
      weighted-average shares outstanding used for calculating net loss per share:
                                                                                                      
      basic
                                137,108 131,663 134,326 131,352 124,814 108,221 109,846 105,044 103,564 101,826 102,769 101,563 99,471 96,068 96,864 95,728 93,411 74,767 75,194 72,899 72,088 67,569,000 69,791,000 69,727,000 59,730,000 54,515,000 54,875,000 54,418,000 53,088,000 48,050,000 47,710,000 47,620,000 47,450 40,300   38,830 34,750   32,590 32,430 32,530 32,450 32,210 31,870 31,850 31,810 31,760 26,870 27,800 27,770 23,040 22,350                 
      diluted
                                137,108 131,663 134,326 131,352 124,814 108,221 109,846 105,044 103,564 101,826 102,769 101,563 99,471 96,905 97,605 95,728 94,662 76,534 76,103 74,517 75,158 67,569,000 69,791,000 71,928,000 59,730,000 55,061,000 55,377,000 55,236,000 53,088,000 48,050,000 48,820,000 47,620,000 47,450 40,300   38,830 34,750   32,590 32,430 32,530 32,450 32,210 31,870 31,850 31,810 31,760 26,870 27,800 27,770 23,040 23,950                 
      non-operating income, net:
                                                                                                      
      total non-operating income
                                 -687,000 -532,000 -652,000  385,250 -986,000 2,997,000  399,000 -533,000 -444,000 -706,000 -1,513,000 601,000 -2,482,000 4,930,000     1,999,000 -12,016,000 438,000  2,124,000 871,000 2,892,000  837,500 4,984,000   2,120,000 -128,000 -1,880,000                                   
      government contracts revenue
                                     1,345,000 2,285,000 1,667,000 1,428,000 1,831,000 261,000                                                            
      amortization of intangible assets
                                     51,000 50,000 51,000 50,000 51,000 50,000 51,000 50,000 51,000 50,000 51,000 50,000 51,000 50,000 51,000 50,000 51,000 50,000 51,000 50,000 51,000 50,000 51,000 50,000 50,000 51,000 51,000 50,000                                      
      gain from revaluation of warrant liability
                                             -1,132,000 1,109,000 -2,707,000 6,296,000 -6,555,000 1,738,000 3,491,000 9,034,000         -3,336,000 5,439,000                                        
      revenue
                                           9,251,000 7,632,000 9,656,000 8,045,000 8,830,000 7,692,000 6,707,250 10,362,000 8,601,000                                                   
      yoy
                                           4.77% -0.78% 43.96% -22.36% 2.66%                                                       
      qoq
                                           21.21% -20.96% 20.02% -8.89% 14.79% 14.68% -35.27% 20.47%                                                    
      cost of revenue
                                           4,976,000 4,263,000 6,162,000 5,560,000 7,028,000 4,714,000 3,649,500 5,689,000 4,752,000                                                   
      gross profit
                                           4,275,000 3,369,000     3,057,750 4,673,000 3,849,000      2,689,750 3,841,000 3,650,000 3,268,000 3,961,000 4,599,000 2,775,000 3,174,000 2,831,000 2,667,000 3,001,000 2,564,000 1,750,000 572,000 1,686,000 1,394,000 662,000 1,969,000 953,000 3,255,000                          
      yoy
                                                         -32.09% -16.48% 31.53% 2.96% 39.92% 72.44% -7.53% 23.79% 61.77% 366.26% 78.00% 83.93% 164.35% -70.95% 76.92% -57.17%                              
      qoq
                                           26.89%      -34.57% 21.41%       -29.97% 5.23% 11.69% -17.50% -13.87% 65.73% -12.57% 12.12% 6.15% -11.13% 17.04% 46.51% 205.94% -66.07% 20.95% 110.57% -66.38% 106.61% -70.72%                           
      gross margin %
    NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% 46.21% 44.14% 0% 0% 0% 0% 45.59% 45.10% 44.75% NaN% NaN% NaN% NaN% NaN% Infinity% Infinity% Infinity% Infinity% Infinity% Infinity% Infinity% Infinity% Infinity% Infinity% Infinity% Infinity% Infinity% Infinity% Infinity% Infinity% Infinity% Infinity% Infinity% Infinity% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% 
      gross profit on revenue
                                             1,816,250 2,485,000 1,802,000 2,978,000                                                      
      weighted-average shares outstanding used in the calculation of net loss per share:
                                                                                                      
      basic
                                137,108 131,663 134,326 131,352 124,814 108,221 109,846 105,044 103,564 101,826 102,769 101,563 99,471 96,068 96,864 95,728 93,411 74,767 75,194 72,899 72,088 67,569,000 69,791,000 69,727,000 59,730,000 54,515,000 54,875,000 54,418,000 53,088,000 48,050,000 47,710,000 47,620,000 47,450 40,300   38,830 34,750   32,590 32,430 32,530 32,450 32,210 31,870 31,850 31,810 31,760 26,870 27,800 27,770 23,040 22,350                 
      diluted
                                137,108 131,663 134,326 131,352 124,814 108,221 109,846 105,044 103,564 101,826 102,769 101,563 99,471 96,905 97,605 95,728 94,662 76,534 76,103 74,517 75,158 67,569,000 69,791,000 71,928,000 59,730,000 55,061,000 55,377,000 55,236,000 53,088,000 48,050,000 48,820,000 47,620,000 47,450 40,300   38,830 34,750   32,590 32,430 32,530 32,450 32,210 31,870 31,850 31,810 31,760 26,870 27,800 27,770 23,040 23,950                 
      non-operating gain (expense), net:
                                                                                                      
      total non-operating gain (expense)
                                                 3,272,750 600,000 3,459,000 9,032,000                                                  
      revenue:
                                                                                                      
      government grants and cooperative agreements revenue
                                                                                                      
      revaluation of warrant liability
                                                     1,704,000 -12,416,000 686,000  1,973,000 873,000 3,674,000     -1,278,000                                      
      net loss per common share:
                                                                                                      
      basic
                                                     -80 -290 -100 -170   -40 -170   -130              -265 -290 -560                       
      diluted
                                                     -80 -290 -100 -170   -100 -170   -130              -265 -290 -560                       
      weighted-average common shares outstanding used for calculating net loss per common share:
                                                                                                      
      basic
                                137,108 131,663 134,326 131,352 124,814 108,221 109,846 105,044 103,564 101,826 102,769 101,563 99,471 96,068 96,864 95,728 93,411 74,767 75,194 72,899 72,088 67,569,000 69,791,000 69,727,000 59,730,000 54,515,000 54,875,000 54,418,000 53,088,000 48,050,000 47,710,000 47,620,000 47,450 40,300   38,830 34,750   32,590 32,430 32,530 32,450 32,210 31,870 31,850 31,810 31,760 26,870 27,800 27,770 23,040 22,350                 
      diluted
                                137,108 131,663 134,326 131,352 124,814 108,221 109,846 105,044 103,564 101,826 102,769 101,563 99,471 96,905 97,605 95,728 94,662 76,534 76,103 74,517 75,158 67,569,000 69,791,000 71,928,000 59,730,000 55,061,000 55,377,000 55,236,000 53,088,000 48,050,000 48,820,000 47,620,000 47,450 40,300   38,830 34,750   32,590 32,430 32,530 32,450 32,210 31,870 31,850 31,810 31,760 26,870 27,800 27,770 23,040 23,950                 
      loss from revaluation of warrant liability
                                                        -5,073,000    -4,461,000   -339,000                                       
      government grants and cooperative agreements
                                                         22,750   91,000 527,000 1,479,000  436,000             -4,133,000 938,000 2,713,000  1,081,000 4,583,000 1,480,000  2,642,000 3,519,000 2,800,000 3,228,000 2,247,750 2,324,000 3,301,000 3,366,000 2,587,000 1,882,000 1,080,000 563,000 613,000 398,000 217,000 314,000 373,000 
      total revenue
                                                         6,564,500 8,252,000 9,224,000 8,782,000 10,423,000 9,249,000 6,753,000 6,619,000 6,461,000 4,991,000 5,935,000 5,722,000 5,474,000 4,814,000 4,206,000 3,488,000 3,626,000 3,882,000 4,030,000 4,969,000 -1,868,000 3,700,000 4,514,000 4,698,000 14,149,000 7,974,000 6,460,000 6,997,000 5,610,000 6,880,000 5,480,000 6,401,000 2,738,000 3,539,000 3,766,000 3,647,000 2,868,000 2,003,000 1,269,000 730,000 5,649,000 503,000 517,000 1,559,000 1,444,000 
      net income per common share:
                                                                                                      
      basic
                                -0.14 -0.12 -0.11 -0.1 -0.11 -0.1 -0.12 -0.16 -0.18 -0.13 -0.14 -0.18 -0.17 -0.15 -0.16 -0.17 -0.1 -0.27 -0.14 -0.1      -65 -60   -47.5 50                  -210 120 -60 -180 -40                  
      diluted
                                -0.14 -0.12 -0.11 -0.1 -0.11 -0.1 -0.12 -0.16 -0.18 -0.13 -0.14 -0.18 -0.17 -0.13 -0.17 -0.17 -0.17 -0.17 -0.16 -0.16 -0.12     -65 -80   -47.5 50                  -210 120 -60 -180 -40                  
      weighted-average common shares outstanding used for calculating net income per common share:
                                                                                                      
      basic
                                137,108 131,663 134,326 131,352 124,814 108,221 109,846 105,044 103,564 101,826 102,769 101,563 99,471 96,068 96,864 95,728 93,411 74,767 75,194 72,899 72,088 67,569,000 69,791,000 69,727,000 59,730,000 54,515,000 54,875,000 54,418,000 53,088,000 48,050,000 47,710,000 47,620,000 47,450 40,300   38,830 34,750   32,590 32,430 32,530 32,450 32,210 31,870 31,850 31,810 31,760 26,870 27,800 27,770 23,040 22,350                 
      diluted
                                137,108 131,663 134,326 131,352 124,814 108,221 109,846 105,044 103,564 101,826 102,769 101,563 99,471 96,905 97,605 95,728 94,662 76,534 76,103 74,517 75,158 67,569,000 69,791,000 71,928,000 59,730,000 55,061,000 55,377,000 55,236,000 53,088,000 48,050,000 48,820,000 47,620,000 47,450 40,300   38,830 34,750   32,590 32,430 32,530 32,450 32,210 31,870 31,850 31,810 31,760 26,870 27,800 27,770 23,040 23,950                 
      acquisition related costs
                                                                                                      
      non-operating income:
                                                                                                      
      other expense
                                                             -6,250 -22,000 -19,000                                       
      net loss per common share:
                                                                                                      
      net income per share
                                                                -0.11 -0.093 -0.1 -0.14 -0.13 -0.145 -0.16 -0.19 -0.23 -0.18 -0.27 -0.28 -0.16            0.96 -0.24 -0.23 -0.52 -0.42 -0.64 -0.97 -1.07 -1.05 -0.71 -0.86 -0.81 -0.8 -0.79 
      weighted-average common shares outstanding used for basic and diluted net loss per share:
                                                                                                      
      basic
                                137,108 131,663 134,326 131,352 124,814 108,221 109,846 105,044 103,564 101,826 102,769 101,563 99,471 96,068 96,864 95,728 93,411 74,767 75,194 72,899 72,088 67,569,000 69,791,000 69,727,000 59,730,000 54,515,000 54,875,000 54,418,000 53,088,000 48,050,000 47,710,000 47,620,000 47,450 40,300   38,830 34,750   32,590 32,430 32,530 32,450 32,210 31,870 31,850 31,810 31,760 26,870 27,800 27,770 23,040 22,350                 
      diluted
                                137,108 131,663 134,326 131,352 124,814 108,221 109,846 105,044 103,564 101,826 102,769 101,563 99,471 96,905 97,605 95,728 94,662 76,534 76,103 74,517 75,158 67,569,000 69,791,000 71,928,000 59,730,000 55,061,000 55,377,000 55,236,000 53,088,000 48,050,000 48,820,000 47,620,000 47,450 40,300   38,830 34,750   32,590 32,430 32,530 32,450 32,210 31,870 31,850 31,810 31,760 26,870 27,800 27,770 23,040 23,950                 
      government grants and cooperative agreement
                                                                 234,000 470,000 245,000 222,000 246,250 247,000 335,000 403,000 226,000 787,000  117,000    3,511,000    2,701,000                  
      warrant liability revaluation
                                                                 -584,000 -721,000 -653,000                                   
      per share information:
                                                                                                      
      weighted-average common shares outstanding basic and diluted
                                                                  39,310 38,940                                   
      weighted-average common shares outstanding used for basic and per share information:
                                                                                                      
      basic and diluted
    194,142 190,594 191,830 191,301 187,066 184,563 185,424 184,982 182,090 180,270 180,938 180,611 178,273 176,545 177,236 176,944 174,478 171,279 171,904 171,240 168,824 163,949 166,572 164,383 157,405 139,831 140,908 138,281                                       35,000 32,650                               
      weighted-average common shares outstanding used for basic and diluted per share information:
                                                                                                      
      basic and diluted
    194,142 190,594 191,830 191,301 187,066 184,563 185,424 184,982 182,090 180,270 180,938 180,611 178,273 176,545 177,236 176,944 174,478 171,279 171,904 171,240 168,824 163,949 166,572 164,383 157,405 139,831 140,908 138,281                                       35,000 32,650                               
      interest income and other
                                                                        34,000   63,000 1,338,000 648,000 1,334,000 996,000 1,088,000 865,000 915,000 868,000 2,053,000                  
      impairment of long-term investment in related party
                                                                               9,450,000                       
      interest and other income
                                                                         41,000 -1,237,000                            
      loss from continuing operations
                                                                         -5,800,750 -8,818,000 -9,093,000                           
      discontinued operations:
                                                                                                      
      loss from discontinued operations
                                                                                                      
      loss from continuing operations per share – basic and diluted
                                                                         -0.18 -0.27                            
      loss from discontinued operations per share – basic and diluted
                                                                                                      
      weighted-average common shares outstanding used for basic and per share information:
                                                                                                      
      basic
                                137,108 131,663 134,326 131,352 124,814 108,221 109,846 105,044 103,564 101,826 102,769 101,563 99,471 96,068 96,864 95,728 93,411 74,767 75,194 72,899 72,088 67,569,000 69,791,000 69,727,000 59,730,000 54,515,000 54,875,000 54,418,000 53,088,000 48,050,000 47,710,000 47,620,000 47,450 40,300   38,830 34,750   32,590 32,430 32,530 32,450 32,210 31,870 31,850 31,810 31,760 26,870 27,800 27,770 23,040 22,350                 
      diluted
                                137,108 131,663 134,326 131,352 124,814 108,221 109,846 105,044 103,564 101,826 102,769 101,563 99,471 96,905 97,605 95,728 94,662 76,534 76,103 74,517 75,158 67,569,000 69,791,000 71,928,000 59,730,000 55,061,000 55,377,000 55,236,000 53,088,000 48,050,000 48,820,000 47,620,000 47,450 40,300   38,830 34,750   32,590 32,430 32,530 32,450 32,210 31,870 31,850 31,810 31,760 26,870 27,800 27,770 23,040 23,950                 
      loss from continuing operations per share –basic and diluted
                                                                           -0.28                           
      loss from discontinued operations per share –basic and diluted
                                                                                                      
      net income from continuing operations
                                                                            -5,292,000                          
      net loss from discontinued operations
                                                                                                      
      net loss from continuing operations per share – basic and diluted
                                                                            -0.16                          
      net loss from discontinued operations per share – basic and diluted
                                                                                                      
      milestone and development funding
                                                                             32,500  130,000  12,142,000 2,597,000 4,204,000 3,817,000                  
      milestone and development revenue from related party
                                                                                                      
      weighted-average common shares outstanding used for basic and diluted net income per share:
                                                                                                      
      basic
                                137,108 131,663 134,326 131,352 124,814 108,221 109,846 105,044 103,564 101,826 102,769 101,563 99,471 96,068 96,864 95,728 93,411 74,767 75,194 72,899 72,088 67,569,000 69,791,000 69,727,000 59,730,000 54,515,000 54,875,000 54,418,000 53,088,000 48,050,000 47,710,000 47,620,000 47,450 40,300   38,830 34,750   32,590 32,430 32,530 32,450 32,210 31,870 31,850 31,810 31,760 26,870 27,800 27,770 23,040 22,350                 
      diluted
                                137,108 131,663 134,326 131,352 124,814 108,221 109,846 105,044 103,564 101,826 102,769 101,563 99,471 96,905 97,605 95,728 94,662 76,534 76,103 74,517 75,158 67,569,000 69,791,000 71,928,000 59,730,000 55,061,000 55,377,000 55,236,000 53,088,000 48,050,000 48,820,000 47,620,000 47,450 40,300   38,830 34,750   32,590 32,430 32,530 32,450 32,210 31,870 31,850 31,810 31,760 26,870 27,800 27,770 23,040 23,950                 
      gain on loan settlement
                                                                                        22,089,000              
      development funding
                                                                                     2,204,750 3,292,000 2,594,000             1,245,000  
      product sales
                                                                                     90,000 69,000 86,000 240,000     24,000 8,000 20,000       
      general and administrative
                                                                                     2,380,000 2,161,000 2,616,000 2,421,000 2,274,000 1,989,000 2,919,000 3,043,000 2,587,000 2,823,000 2,695,000 2,925,000 3,024,000 2,802,000 2,347,000 2,658,000 2,379,000 
      interest income
                                                                                     215,500 241,000 256,000 365,000        485,000 575,000 673,000 1,298,000 1,210,000 1,188,000 
      net income (loss) per share - basic
                                                                                     0.19 -0.07 -0.12               
      net income (loss) per share - diluted
                                                                                     0.18 -0.07 -0.12               
      shares used in computing net income per share - basic
                                                                                     5,579.25 22,373 22,321 22,257              
      shares used in computing net income per share - diluted
                                                                                     5,923.5 22,373 22,321 23,285              
      development funding, related parties
                                                                                        2,027,000 228,250 420,000        2,000 69,000   
      development funding, other
                                                                                        906,000 262,000 795,000 164,000 89,000 257,000 113,000 169,000 167,000 36,000 103,000 231,000   
      interest expense and other income
                                                                                                      
      shares used in computing net loss per share - basic and diluted
                                                                                         5,530.25 22,166 22,113 22,084 22,031 17,317 15,964 15,874 15,782 15,751 15,711  14,097 
      development funding, related party
                                                                                           301,000 192,000          
      milestone and development funding, related parties
                                                                                                 5,000,000     
      interest income (expense)
                                                                                                      
      income before provision for income taxes
                                                                                                     -11,065,000 
      shares used in computing net loss per share
                                                                                                      
      - basic and diluted
                                                                                                    14,887  
      milestones and development funding
                                                                                                     1,071,000 
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 2009-12-31 2009-09-30 2009-06-30 2009-03-31 2008-12-31 2008-09-30 2008-06-30 2008-03-31 2007-12-31 2007-09-30 2007-06-30 2007-03-31 2006-12-31 2006-09-30 2006-06-30 2006-03-31 2005-12-31 2005-09-30 2005-06-30 2005-03-31 2004-12-31 2004-09-30 2004-06-30 2004-03-31 2003-09-30 2003-06-30 2003-03-31 2002-09-30 2002-06-30 2002-03-31 2001-09-30 2001-06-30 2001-03-31 
                                                                                                        
        assets
                                                                                                        
        current assets:
                                                                                                        
        cash and cash equivalents
      27,850,000 19,961,000 15,670,000 15,991,000 19,476,000 20,266,000 21,575,000 12,402,000 20,527,000 11,647,000 17,389,000 20,635,000 27,604,000 35,585,000 28,875,000 32,309,000 38,372,000 48,759,000 78,460,000 59,030,000 57,607,000 36,594,000 28,950,000 34,900,000 33,679,000 34,986,000 24,425,000 23,543,000 29,002,000 28,859,000 22,327,000 14,305,000 14,877,000 13,683,000 16,985,000 20,278,000 10,930,000 22,560,000 12,880,000 7,704,000 20,791,000 71,018,000 50,795,000 35,059,000 17,934,000 22,781,000 22,343,000 28,562,000 23,992,000 29,485,000 24,355,000 58,201,000 69,163,000 26,696,000 26,661,000 26,667,000 31,449,000 25,497,000 14,761,000 17,167,000 23,599,000 28,948,000 11,884,000 14,139,000 16,813,000 17,287,000 19,466,000 7,790,000 6,983,000 10,303,000 15,306,000 22,405,000 21,743,000 19,625,000 37,986,000 33,287,000 39,192,000 46,287,000 42,566,000 56,696,000 52,787,000 5,780,000 5,405,000 4,933,000 4,836,000 39,169,000 7,614,000 7,900,000 25,743,000 52,878,000 92,828,000 55,347,000 42,128,000 26,491,000 47,956,000 99,301,000 138,368,000 69,212,000 
        short-term investments
      52,575,000 62,918,000 62,842,000 62,034,000 61,443,000 60,186,000 53,990,000 58,792,000 51,651,000 54,205,000 61,617,000 63,868,000 67,076,000 66,569,000 74,952,000 74,738,000 70,185,000 80,600,000 41,501,000 63,811,000 74,118,000 97,000,000 106,174,000 101,570,000 99,426,000 50,732,000 60,686,000 72,659,000 71,426,000 88,718,000 96,669,000 97,605,000 90,988,000 47,013,000 42,645,000 30,628,000 39,117,000 45,116,000 63,396,000 76,350,000 70,513,000 25,698,000 48,968,000 75,854,000 93,959,000 28,513,000 25,231,000 21,134,000 24,263,000 28,191,000       87,000 287,000 457,000 613,000 758,000 1,061,000 1,325,000 1,725,000 2,173,000 2,644,000 3,194,000 5,072,000 8,436,000 12,275,000 14,185,000 16,564,000 24,971,000 37,225,000 31,049,000 41,148,000 40,422,000 47,129,000 27,025,000 19,428,000 30,042,000 40,025,000 43,835,000 47,242,000 51,022,000 56,165,000 81,973,000 86,917,000 73,703,000 70,247,000 42,956,000 41,059,000 39,667,000 66,783,000 59,540,000 38,602,000 8,933,000 10,902,000 
        accounts receivable
      29,322,000 30,374,000 29,772,000 31,394,000 26,344,000 29,777,000 24,361,000 23,740,000 22,535,000 35,500,000 24,546,000 22,175,000 25,242,000 34,426,000 28,151,000 26,837,000 25,645,000 25,129,000 22,439,000 22,865,000 18,253,000 21,166,000 16,236,000 17,624,000 18,165,000 16,882,000 14,502,000 13,432,000 13,756,000 8,752,000 10,476,000 11,388,000 10,489,000 12,415,000 10,476,000 7,932,000 5,583,000 6,868,000 7,441,000 5,149,000 4,086,000 5,794,000 5,646,000 5,425,000 5,153,000 5,493,000 7,366,000 4,478,000 4,943,000 6,125,000 7,025,000 5,868,000 4,733,000 4,444,000 3,950,000 3,725,000 5,022,000 6,096,000 4,783,000 4,420,000 4,800,000 4,792,000 3,512,000 3,467,000 3,639,000 3,625,000 6,124,000 6,133,000 6,346,000 7,152,000 7,078,000 7,337,000 7,633,000 7,772,000 6,876,000 8,393,000 9,304,000 5,279,000                     
        current inventories
      61,123,000 56,101,000 53,139,000 54,529,000 48,161,000 38,150,000 36,538,000 36,290,000 39,862,000 39,868,000 42,661,000 40,608,000 36,614,000 29,003,000 28,329,000 27,758,000 28,521,000 26,793,000 29,420,000                                                                                
        prepaid and other current assets
      4,471,000 5,030,000 5,704,000 4,586,000 6,091,000 3,643,000 4,148,000 3,806,000 3,594,000 3,221,000 4,723,000 3,650,000 5,680,000 4,561,000 4,424,000 3,030,000 10,089,000 5,821,000 6,232,000 8,629,000 7,009,000 5,417,000 6,479,000 6,452,000 5,365,000 6,018,000 5,798,000 8,756,000 4,958,000 7,034,000                             1,082,000 864,000 1,190,000 997,000   1,049,000 1,096,000   1,350,000 1,204,000 1,124,000 1,377,000 1,515,000 2,218,000 1,439,000 1,285,000 1,576,000 2,215,000                     
        total current assets
      175,341,000 174,384,000 167,127,000 168,534,000 161,515,000 152,022,000 140,612,000 135,030,000 138,169,000 144,441,000 150,936,000 150,936,000 162,216,000 170,144,000 164,731,000 164,672,000 172,812,000 187,102,000 178,052,000 185,590,000 181,272,000 183,431,000 177,299,000 178,971,000 178,319,000 128,108,000 126,317,000 135,837,000 134,920,000 146,902,000 150,154,000 141,198,000 133,776,000 89,898,000 88,434,000 74,307,000 75,720,000 94,105,000 108,029,000 112,212,000 119,437,000 130,439,000 128,423,000 144,471,000 136,419,000 74,885,000 72,652,000 70,320,000 67,079,000 78,154,000 74,502,000 77,770,000 87,440,000 43,996,000 43,536,000 40,789,000 46,598,000 39,739,000 30,674,000 33,032,000 39,473,000 41,755,000 25,300,000 26,901,000 30,516,000 32,359,000 38,315,000 29,858,000 34,220,000 42,043,000 48,001,000 59,674,000 65,385,000 73,902,000 81,293,000 88,203,000 93,071,000 102,743,000 81,051,000 83,364,000 91,962,000 51,005,000 54,477,000 56,635,000 60,438,000 99,871,000 94,205,000 100,910,000 106,788,000 127,830,000 140,077,000 100,191,000 83,979,000 101,054,000 110,475,000 138,920,000 148,505,000 81,452,000 
        non-current assets:
                                                                                                        
        property and equipment
      9,248,000 9,204,000 6,583,000 6,891,000 7,047,000 7,154,000 7,437,000 7,781,000 8,099,000 8,640,000 9,252,000 10,254,000 10,831,000 10,969,000 10,647,000 11,201,000 11,659,000 12,208,000 12,684,000 12,811,000 13,283,000 13,867,000 14,261,000 14,534,000 14,654,000 14,898,000 15,218,000 15,345,000 16,089,000 8,130,000 3,124,000 2,157,000 1,969,000 2,119,000 2,342,000 2,673,000 2,842,000 2,985,000 3,206,000 3,216,000 3,380,000 3,549,000 3,712,000 3,816,000 3,797,000 3,781,000 3,882,000 3,615,000 3,166,000 2,189,000 1,848,000 1,641,000 1,595,000 1,698,000 1,801,000 1,866,000 1,917,000 2,032,000 2,045,000 2,141,000 2,274,000 2,390,000 2,552,000 1,691,000 1,116,000 1,217,000 1,352,000 1,465,000 1,712,000 1,844,000 1,561,000 1,718,000 1,695,000 1,322,000 1,397,000 1,450,000 1,550,000 1,627,000                     
        operating lease right-of-use assets
      9,450,000 10,124,000 8,082,000 8,665,000 9,101,000 8,384,000 8,936,000 9,581,000 10,224,000 10,713,000 11,029,000 12,268,000 12,313,000 12,512,000 12,890,000 13,259,000 13,665,000 12,971,000 12,409,000 12,477,000 12,801,000 13,122,000 13,470,000 13,768,000 14,080,000 14,122,000 14,110,000 14,417,000 15,631,000                                                                      
        goodwill
      1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000 1,316,000                                     
        restricted cash
      631,000 639,000 1,139,000 1,140,000 1,109,000 1,095,000 1,634,000 1,708,000 1,708,000 1,712,000 1,770,000 1,793,000 1,785,000 1,773,000 1,998,000 2,014,000 2,003,000 2,285,000 2,278,000 2,256,000 2,200,000 2,309,000 2,522,000 2,460,000 2,439,000 2,435,000 2,672,000 2,677,000 2,725,000 2,728,000 2,729,000 2,729,000 2,812,000 247,000 256,000 248,000 262,000 184,000 578,000 575,000 574,000 612,000 623,000 622,000 461,000 508,000 301,000 307,000 308,000 308,000 306,000 304,000 302,000 304,000 302,000 301,000 305,000 303,000 306,000 312,000 310,000 305,000 331,000 339,000 326,000 332,000 334,000 315,000 307,000 315,000                             
        non-current inventories
      15,723,000 15,143,000 15,010,000 14,349,000 15,164,000 14,145,000 14,811,000 16,801,000 17,913,000 19,501,000 21,287,000                                                                                        
        other assets
      11,199,000 11,049,000 15,928,000 12,176,000 11,524,000 16,801,000 14,793,000 13,279,000 11,707,000 11,425,000 10,254,000 22,293,000 20,875,000 21,378,000 23,821,000 23,994,000 20,451,000 21,617,000 12,207,000 8,773,000 9,710,000 7,370,000 4,486,000 4,414,000 4,473,000 4,524,000 4,622,000 4,802,000 4,961,000 4,050,000 3,949,000 4,011,000 4,062,000 4,128,000 4,151,000 4,304,000 4,113,000 4,148,000 2,207,000 2,293,000 2,341,000 2,614,000 123,000 140,000 140,000 144,000 51,000 51,000 64,000 70,000 72,000 72,000 58,000 59,000 101,000 144,000 186,000 229,000 413,000 450,000 408,000 451,000 494,000 961,000 539,000 583,000 686,000 720,000 761,000 808,000 848,000 835,000 820,000 1,111,000 508,000 437,000 368,000 272,000 267,000 264,000 269,000 245,000 1,260,000 1,260,000 1,260,000 85,000 86,000 117,000 131,000 151,000 154,000 156,000 153,000 218,000 214,000 162,000 137,000 127,000 
        total assets
      222,908,000 221,859,000 215,185,000 213,071,000 206,776,000 200,917,000 189,539,000 185,496,000 189,136,000 197,748,000 205,844,000 198,860,000 209,336,000 218,092,000 215,403,000 216,456,000 221,906,000 237,499,000 218,946,000 223,223,000 220,582,000 221,415,000 213,354,000 215,494,000 215,363,000 165,535,000 164,438,000 174,627,000 175,926,000 163,460,000 161,657,000 151,846,000 144,421,000 98,244,000 97,086,000 83,485,000 84,941,000 103,476,000 116,125,000 120,451,000 127,938,000 139,470,000 135,188,000 151,406,000 143,225,000 81,776,000 79,395,000 76,852,000 73,227,000 83,381,000 79,439,000 82,548,000 92,207,000 48,919,000 48,653,000 46,063,000 52,020,000 45,367,000 36,552,000 39,100,000 45,680,000 48,167,000 32,160,000 29,892,000 32,497,000 34,491,000 43,027,000 34,561,000 39,164,000 47,339,000 52,398,000 64,210,000 70,020,000 78,209,000 85,030,000 91,815,000 106,164,000 115,817,000 89,010,000 91,362,000 99,953,000 58,660,000 56,802,000 58,785,000 62,578,000 102,078,000 96,303,000 102,210,000 108,786,000 131,369,000 144,323,000 105,185,000 90,296,000 107,546,000 116,074,000 141,799,000 151,546,000 84,485,000 
        liabilities and stockholders’ equity
                                                                                                        
        current liabilities:
                                                                                                        
        accounts payable
      31,789,000 28,008,000 25,468,000 30,518,000 27,677,000 21,695,000 15,864,000 16,739,000 16,616,000 23,842,000 38,519,000 37,489,000 36,436,000 33,002,000 29,815,000 29,355,000 31,474,000 35,608,000 26,187,000 30,891,000 22,538,000 24,213,000 19,244,000 18,831,000 20,185,000 22,185,000 19,964,000 21,058,000 20,912,000 18,595,000 14,333,000 11,307,000 11,231,000 10,974,000 12,501,000 9,564,000 8,789,000 8,587,000 6,859,000 7,190,000 6,238,000 5,217,000 6,813,000 5,765,000 10,510,000 9,882,000 4,115,000 3,169,000 3,493,000 5,674,000 4,076,000 5,035,000 3,887,000 7,186,000 5,700,000 3,508,000 4,150,000 4,680,000 3,780,000 4,682,000 5,231,000 3,230,000 3,076,000 3,513,000 2,898,000 4,423,000 8,096,000 6,946,000 6,531,000 7,963,000 6,398,000 6,213,000 7,631,000 10,107,000 9,369,000 6,056,000 3,194,000 6,665,000 2,067,000 1,211,000 1,763,000 2,092,000 1,700,000 1,309,000 1,383,000 1,280,000 918,000 1,486,000 1,124,000 2,637,000 1,719,000 1,991,000 2,687,000 3,655,000 3,432,000 2,895,000 3,059,000 3,457,000 
        accrued liabilities
      18,332,000 25,271,000 21,822,000 20,900,000 16,935,000 18,943,000 15,879,000 15,048,000 16,154,000 19,225,000 19,620,000 17,510,000 19,287,000 25,203,000 20,059,000 18,275,000 16,948,000 25,673,000 26,184,000 23,207,000 19,746,000 24,753,000 19,545,000 16,865,000 17,198,000 20,951,000 18,449,000 16,654,000 18,397,000 19,800,000 16,764,000 12,508,000 10,357,000 11,712,000 10,681,000 9,787,000 9,492,000 11,218,000 10,170,000 9,439,000 9,221,000 9,853,000 8,108,000 6,914,000 7,104,000 8,444,000 12,547,000 10,619,000 8,838,000 9,813,000 12,060,000 8,748,000 8,149,000 7,619,000 8,087,000 6,575,000 7,497,000 5,825,000 5,687,000 5,334,000 5,353,000 6,003,000 5,052,000 4,147,000 3,564,000 5,286,000 5,641,000 4,864,000 4,067,000 4,490,000 6,078,000 9,895,000 5,842,000 6,679,000 6,422,000 8,057,000 7,655,000 7,479,000 8,062,000 6,604,000 6,425,000                  
        debt – current
      52,397,000 43,343,000 36,249,000 28,125,000 20,097,000 19,297,000 18,521,000 18,782,000 20,120,000 20,000,000 18,779,000 16,542,000 18,000,000 56,159,000 42,380,000 28,680,000 15,011,000 14,697,000 9,986,000 9,329,000 9,938,000 8,516,000 4,982,000 4,950,000 4,813,000 5,017,000     5,714,000 3,572,000 1,429,000                                                                  
        operating lease liabilities – current
      3,144,000 2,905,000 2,613,000 2,604,000 2,532,000 2,275,000 2,260,000 2,219,000 2,188,000 2,452,000 2,268,000 2,176,000 2,157,000 2,105,000 2,011,000 1,994,000 1,968,000 1,905,000 1,616,000 1,517,000 1,486,000 1,915,000 1,857,000 1,793,000 1,751,000 1,613,000 1,592,000 1,711,000 1,560,000                                                                      
        deferred revenue
      1,721,000 1,274,000 2,281,000 2,211,000 2,449,000 1,398,000 1,821,000 1,096,000 2,167,000 2,002,000                                     560,000 266,000 279,000 181,000 111,000 153,000 174,000 77,000 716,000 136,000 197,000 111,000 74,000 123,000 161,000 248,000 233,000 212,000 375,000 345,000 303,000 659,000 410,000 445,000 85,000 60,000 289,000 1,504,000 39,000 32,000 126,000  2,054,000 4,107,000 7,572,000 11,135,000 6,630,000 8,549,000 10,469,000 13,217,000 3,690,000 1,584,000 641,000 611,000 647,000 682,000 754,000 789,000 825,000 1,166,000 937,000 964,000 
        total current liabilities
      107,383,000 100,801,000 88,433,000 84,358,000 69,690,000 63,608,000 54,345,000 53,884,000 57,245,000 67,521,000 80,122,000 75,078,000 77,573,000 117,058,000 95,019,000 79,279,000 66,659,000 78,556,000 64,717,000 65,815,000 54,764,000 59,974,000 46,189,000 43,145,000 45,089,000 50,336,000 45,559,000 50,782,000 47,594,000 52,678,000 43,202,000 28,063,000 23,656,000 23,131,000 23,868,000 25,297,000 26,444,000 26,888,000 22,890,000 25,744,000 22,818,000 21,895,000 19,918,000 22,224,000 22,764,000 29,187,000 21,153,000 21,707,000 27,234,000 39,424,000 42,591,000 26,383,000 27,656,000 25,613,000 27,298,000 22,660,000 27,383,000 21,114,000 14,184,000 22,108,000 22,309,000 19,703,000 14,708,000 13,030,000 10,936,000 12,913,000 17,057,000 12,830,000 11,660,000 12,898,000 12,570,000 16,185,000 13,786,000 18,320,000 15,862,000 14,193,000 11,138,000 14,814,000 15,803,000 17,195,000 21,612,000 23,317,000 13,298,000 13,805,000 15,155,000 76,089,000 69,304,000 70,227,000 65,322,000 68,675,000 14,837,000 14,587,000 18,351,000 19,360,000 16,880,000 17,133,000 14,917,000 12,736,000 
        non-current liabilities:
                                                                                                        
        debt – non-current
      32,434,000 40,545,000 48,655,000 56,766,000 64,876,000 64,862,000 64,847,000 64,840,000 64,826,000 59,796,000 59,789,000 54,838,000 54,827,000 13,644,000 27,357,000 41,065,000 54,769,000 54,724,000 54,675,000 54,682,000 54,616,000 39,588,000 39,545,000 39,500,000 39,458,000 39,414,000 39,371,000 39,327,000 39,433,000  24,138,000                                                                    
        operating lease liabilities – non-current
      9,383,000 10,153,000 10,669,000 11,403,000 11,941,000 11,663,000 12,270,000 12,851,000 13,469,000 13,751,000 14,083,000 14,454,000 14,960,000 15,329,000 15,703,000 16,221,000 16,787,000 16,260,000 16,079,000 16,319,000 16,697,000 16,873,000 17,263,000 17,611,000 18,005,000 18,406,000 18,458,000 18,722,000 19,311,000                                                                      
        other non-current liabilities
      5,422,000 5,395,000 5,224,000 4,374,000 4,027,000 3,888,000 3,796,000 3,620,000 3,434,000 3,236,000 2,827,000 2,800,000 2,414,000 3,499,000 3,251,000 3,130,000 3,280,000 2,342,000 2,400,000 2,170,000 1,870,000 1,174,000 1,122,000 713,000 403,000 327,000 242,000 164,000 88,000 4,250,000 2,516,000 1,329,000 784,000 609,000 632,000 1,632,000 1,622,000 1,440,000 1,396,000 1,356,000 1,314,000 1,263,000 1,215,000 1,160,000 1,116,000 1,081,000 998,000 987,000 1,031,000 1,073,000 1,120,000 1,145,000 1,209,000 1,241,000 1,132,000 1,167,000 1,203,000 1,243,000 1,290,000 1,588,000 1,595,000 1,595,000 1,545,000 737,000 62,000  130,000 138,000 142,000  224,000 213,000 226,000                          
        total liabilities
      154,622,000 156,894,000 152,981,000 156,901,000 150,534,000 144,021,000 135,258,000 135,195,000 138,974,000 144,304,000 156,821,000 147,170,000 149,774,000 149,530,000 141,330,000 139,695,000 141,495,000 151,882,000 137,871,000 138,986,000 127,947,000 117,609,000 104,119,000 100,969,000 102,955,000 108,483,000 103,630,000 108,995,000 106,426,000 78,941,000 69,856,000 61,402,000 58,823,000 59,304,000 59,903,000 44,194,000 43,454,000 45,689,000 43,812,000 45,810,000 44,404,000 44,705,000 39,667,000 40,877,000 33,288,000 40,255,000 32,119,000 32,644,000 28,360,000 40,586,000 43,793,000 27,603,000 31,419,000 29,812,000 31,737,000 27,544,000 32,712,000 27,054,000 20,384,000 25,855,000 26,561,000 24,435,000 19,852,000 17,814,000 15,509,000 13,043,000 17,205,000 12,968,000 11,802,000 13,061,000 12,794,000 16,398,000 14,012,000 18,322,000 15,868,000 14,210,000 11,165,000 14,846,000 15,844,000 17,260,000 21,732,000 23,385,000                 
        commitments and contingencies
                                                                                                        
        stockholders’ equity:
                                                                                                        
        common stock
      200,000  192,000 191,000 191,000  185,000 185,000 185,000  181,000 181,000 180,000  177,000 177,000 177,000  172,000 172,000 168,000  167,000 166,000 164,000  142,000 140,000 138,000  136,000 133,000 131,000  112,000 109,000 103,000  103,000 102,000 101,000  97,000 97,000 95,000 80,000 77,000 74,000 72,000 72,000 70,000 70,000 70,000 56,000 55,000 55,000 54,000 51,000 48,000 48,000 48,000  40,000 39,000 39,000  38,000 33,000 33,000  33,000 32,000 32,000  32,000 32,000 32,000  28,000 28,000 28,000                  
        additional paid-in capital
      1,150,471,000 1,145,343,000 1,140,416,000 1,134,462,000 1,128,812,000 1,121,887,000 1,116,415,000 1,110,264,000 1,104,605,000 1,098,353,000 1,093,494,000 1,089,083,000 1,083,433,000 1,077,341,000 1,069,629,000 1,062,760,000 1,057,497,000 1,048,936,000 1,034,945,000 1,026,534,000 1,019,436,000 1,012,932,000 1,003,748,000 994,682,000 978,944,000 906,905,000 893,715,000 880,622,000 867,091,000 863,531,000 854,653,000 839,198,000 821,081,000 760,225,000 746,916,000 735,600,000 720,843,000 718,299,000 716,189,000 704,402,000 694,741,000 685,189,000 673,653,000 670,327,000 661,258,000 583,416,000 568,972,000 555,131,000 548,202,000 545,905,000 532,938,000 531,703,000 530,822,000 478,903,000 474,997,000 473,140,000 462,527,000 452,701,000 442,561,000 441,976,000 441,515,000 441,034,000 426,975,000 422,890,000 422,412,000 421,897,000 421,381,000 411,533,000 411,062,000 410,444,000 409,883,000 409,254,000 408,350,000 407,010,000 405,084,000 404,262,000 403,701,000 402,888,000 378,088,000 377,309,000 376,432,000 332,694,000    332,002,000             
        accumulated other comprehensive loss
      -323,000 -156,000 -174,000 -273,000 -266,000 -400,000 -104,000 -867,000 -1,122,000 -1,274,000 -2,225,000 -2,433,000 -2,241,000 -2,787,000 -3,189,000 -2,153,000 -1,635,000            -70,000 -281,000 -326,000 -417,000 -426,000            -12,000      -33,000                        -154,000 -40,000  -23,000 -14,000 -87,000  -295,000                 
        accumulated deficit
      -1,082,795,000 -1,081,155,000 -1,078,971,000 -1,078,952,000 -1,073,245,000 -1,065,528,000 -1,063,007,000 -1,060,073,000 -1,054,298,000 -1,044,610,000 -1,043,282,000 -1,036,015,000 -1,022,740,000 -1,007,121,000 -993,497,000 -985,015,000 -976,626,000 -964,342,000 -955,223,000 -942,786,000 -927,425,000 -909,968,000 -895,587,000 -881,448,000 -866,577,000 -850,111,000 -833,188,000 -815,221,000 -797,659,000 -778,867,000 -762,662,000 -748,470,000 -735,188,000 -721,303,000 -709,817,000 -696,399,000 -679,316,000 -660,718,000 -647,217,000 -632,841,000 -614,675,000 -597,812,000 -583,056,000 -567,376,000 -551,404,000 -541,944,000 -521,762,000 -511,003,000 -503,414,000 -503,189,000 -497,329,000 -476,828,000 -470,104,000 -459,852,000 -458,136,000 -454,676,000 -452,769,000 -443,935,000 -435,938,000 -438,276,000 -431,963,000 -426,953,000 -424,323,000 -420,491,000 -415,064,000 -410,042,000 -405,153,000 -399,516,000 -393,304,000 -385,907,000 -379,929,000 -371,111,000 -362,018,000 -356,726,000 -345,296,000 -336,145,000 -318,230,000 -311,422,000 -314,432,000 -312,644,000 -307,573,000 -306,643,000                 
        total cerus corporation stockholders’ equity
      67,553,000 64,224,000 61,463,000 55,428,000 55,492,000 56,145,000 53,489,000                                                                                            
        noncontrolling interest
      733,000 741,000 741,000 742,000 750,000 751,000 792,000 792,000 792,000 794,000 855,000 874,000 930,000 952,000 953,000 992,000 998,000 998,000 1,000,000                                                                                
        total liabilities and stockholders’ equity
      222,908,000 221,859,000 215,185,000 213,071,000 206,776,000 200,917,000 189,539,000                                  127,938,000 139,470,000 135,188,000 151,406,000 143,225,000 81,776,000 79,395,000 76,852,000 73,227,000 83,381,000 79,439,000 82,548,000 92,207,000 48,919,000 48,653,000 46,063,000 52,020,000 45,367,000 36,552,000 39,100,000 45,680,000 48,167,000 32,160,000 29,892,000 32,497,000 34,491,000 43,027,000 34,561,000 39,164,000 47,339,000 52,398,000 64,210,000 70,020,000 78,209,000 85,030,000 91,815,000 106,164,000 115,817,000 89,010,000 91,362,000 99,953,000 58,660,000 56,802,000 58,785,000 62,578,000 102,078,000 96,303,000 102,210,000 108,786,000 131,369,000 144,323,000 105,185,000 90,296,000 107,546,000 116,074,000 141,799,000 151,546,000 84,485,000 
        preferred stock, 0.001 par value...
                                                                                                        
        common stock, 0.001 par value...
       192,000    186,000    181,000    177,000    174,000    168,000    144,000    136,000    115,000    103,000    99,000                    47,000    39,000    33,000    32,000    32,000    23,000    22,000             
        liabilities and stockholders' equity
                                                                                                        
        stockholders' equity:
                                                                                                        
        total cerus corporation stockholders' equity
             49,509,000 49,370,000 52,650,000 48,168,000 50,816,000 58,632,000 67,610,000 73,120,000 75,769,000 79,413,000 84,619,000 80,075,000                                                                                
        total liabilities and stockholders' equity
             185,496,000 189,136,000 197,748,000 205,844,000 198,860,000 209,336,000 218,092,000 215,403,000 216,456,000 221,906,000 237,499,000 218,946,000 223,223,000 220,582,000 221,415,000 213,354,000 215,494,000 215,363,000 165,535,000 164,438,000 174,627,000 175,926,000 163,460,000 161,657,000 151,846,000 144,421,000 98,244,000 97,086,000 83,485,000 84,941,000 103,476,000 116,125,000 120,451,000                                                           
        deferred product revenue
                936,000 1,361,000 1,693,000 589,000 754,000 975,000 1,258,000 673,000 744,000 871,000 1,056,000 577,000 561,000 706,000                                                                           
        accumulated other comprehensive income
                       -149,000 181,000 317,000 456,000 674,000 907,000 1,125,000 -123,000 114,000 139,000 91,000      -97,000 -28,000 -19,000 -143,000 103,000 3,238,000 2,978,000 3,367,000 7,289,000 4,827,000 7,481,000  -31,000 -11,000 6,000 7,000 7,000         1,000 1,000 23,000 108,000 120,000 144,000 105,000 58,000 60,000 47,000 75,000 212,000 121,000 141,000 148,000 75,000                         
        inventories
                         31,255,000 24,285,000 23,254,000 19,460,000 18,425,000 21,684,000 19,490,000 20,906,000 17,447,000 15,778,000 13,539,000 13,322,000 12,930,000 13,165,000 14,457,000 14,250,000 12,213,000 12,919,000 12,531,000 12,202,000 12,111,000 11,255,000 10,812,000 12,842,000 13,681,000 16,109,000 14,956,000 13,503,000 13,377,000 11,307,000 13,063,000 12,686,000 12,762,000 11,756,000 10,180,000 9,682,000 9,373,000 8,903,000 6,444,000 9,591,000 9,968,000 9,126,000 5,957,000 7,334,000 6,267,000 6,842,000 7,707,000 8,354,000 9,755,000 11,105,000 11,109,000 10,308,000 11,991,000 9,523,000 7,062,000 3,943,000 4,090,000 2,577,000 1,833,000 1,836,000 1,896,000                   
        total stockholders' equity
                         84,237,000 92,635,000 103,806,000 109,235,000 114,525,000 112,408,000 57,052,000 60,808,000 65,632,000 69,500,000 84,519,000 91,801,000 90,444,000 85,598,000 38,940,000 37,183,000 39,291,000 41,487,000 57,787,000 72,313,000 74,641,000                                                           
        intangible assets
                             31,000 82,000 132,000 183,000 233,000 284,000 334,000 385,000 435,000 486,000 536,000 587,000 637,000 688,000 738,000 789,000 839,000 890,000 940,000 991,000 1,041,000 1,092,000 1,142,000 1,193,000 1,243,000 1,294,000 1,344,000 1,395,000 1,445,000 1,496,000 1,546,000 1,597,000 1,647,000 1,698,000 1,748,000 1,798,000 1,849,000   3,483,000                                    
        deferred product revenue – current
                              1,142,000 570,000 561,000 665,000 763,000  533,000 676,000 639,000                                                                  
        manufacturing and development obligations
                                 6,198,000 5,962,000                                                                      
        debt – revolving loan
                                4,993,000 4,496,000                                                                       
        debt – term loan
                                                                                                        
        debt - current
                                   7,857,000      5,548,000 7,693,000 6,934,000 4,969,000 6,127,000   1,449,000  591,000    3,268,000  3,638,000 2,157,000 4,470,000  4,919,000  3,099,000                                          
        manufacturing and development obligations – current
                                   5,928,000 5,858,000                                                                    
        deferred product revenue - current
                                   498,000    445,000 686,000 398,000 470,000 149,000 892,000                                                            
        debt - non-current
                                   22,013,000  26,262,000 28,387,000 29,798,000 29,780,000 11,914,000 10,464,000 12,441,000 14,382,000 13,726,000   18,407,000  9,292,000  9,860,000      2,485,000  3,307,000  4,126,000                                          
        manufacturing and development obligations - non-current
                                       5,766,000 5,623,000 5,351,000 4,924,000 4,770,000 5,004,000 4,844,000                                                           
        other current assets
                                    7,360,000 4,970,000 4,257,000 1,109,000 4,078,000 3,256,000 3,461,000 1,804,000 5,457,000 5,345,000 6,333,000 4,788,000 953,000 1,411,000 1,933,000 1,932,000 2,429,000 1,416,000 913,000 442,000 394,000 200,000 418,000 2,038,000    605,000                                   2,129,000 2,752,000 2,951,000 954,000 1,055,000 1,161,000 
        manufacturing and development obligations – non-current
                                     5,748,000 5,996,000                                                                  
        investment in marketable equity securities
                                          3,710,000 3,952,000 4,930,000 4,487,000 5,082,000 11,163,000 7,684,000                                                        
        prepaid expenses
                                       1,221,000    1,274,000 1,723,000 1,066,000 1,377,000 1,166,000 1,535,000 1,009,000 1,331,000 1,210,000 1,780,000 1,353,000 1,661,000 848,000 1,071,000 739,000 1,370,000 638,000    810,000                                         
        manufacturing and development obligations - current
                                             2,221,000                                                           
        deferred income taxes
                                           150,000 140,000 140,000 131,000 122,000 127,000 122,000 116,000 115,000 108,000 102,000 95,000 89,000 82,000 75,000 69,000 62,000                                             
        deferred revenue - current
                                             767,000   306,000  370,000                                                      
        manufacturing and development obligations—current
                                              2,219,000 3,282,000                                                         
        debt—current
                                              4,527,000 2,989,000  2,523,000      3,366,000    4,828,000    2,519,000                                         
        deferred revenue—current
                                              613,000 554,000  577,000  376,000                                                     
        debt—non-current
                                              15,301,000 16,883,000  17,371,000  9,872,000  9,848,000      2,896,000    4,697,000                                         
        manufacturing and development obligations—non-current
                                              4,840,000 4,542,000                                                         
        total stockholders’ equity
                                              83,534,000 94,765,000 95,521,000 110,529,000 109,937,000 41,521,000 47,276,000 44,208,000 44,867,000 42,795,000 35,646,000 54,945,000 60,788,000 19,107,000 16,916,000 18,519,000 19,308,000 18,313,000 16,168,000 13,245,000 19,119,000 23,732,000 12,308,000 12,078,000 16,988,000 21,448,000 25,822,000 21,593,000 27,362,000 34,278,000 39,604,000 47,812,000 56,008,000 59,887,000 69,162,000 77,605,000 94,999,000 100,971,000 73,166,000 74,102,000 78,221,000 35,275,000 38,768,000 40,334,000 42,866,000 21,489,000 26,999,000 31,983,000 43,464,000 62,694,000 76,569,000 39,175,000 71,920,000 83,152,000 94,149,000 119,607,000 131,562,000 66,675,000 
        warrant liability
                                                2,424,000 3,978,000 4,189,000 10,485,000 3,931,000 7,653,000 11,356,000 20,390,000 22,706,000 10,290,000 10,976,000 5,903,000 7,876,000 8,749,000 12,440,000 7,979,000 4,643,000 10,082,000 9,743,000 8,465,000 5,073,000 4,352,000 3,699,000 2,737,000 2,800,000                                
        accrued taxes
                                                818,000 2,467,000                                                       
        investment in aduro biotech, inc.
                                                 12,032,000                                                       
        preferred stock, 0.001 par value 5,000 shares authorized, issuable in series; 0 shares issued and outstanding at december 31, 2013 and 2012
                                                                                                        
        investments
                                                        28,971,000                                                
        preferred stock, 0.001 par value 5,000 shares authorized, issuable in series; 0 and 3 shares issued and outstanding at december 31, 2012 and 2011; respectively, aggregate liquidation preference of 0 and 9,496 at december 31, 2012 and 2011, respectively
                                                                                                        
        prepaid expenses and other current assets
                                                            3,243,000 1,024,000 1,137,000      1,245,000 1,303,000   1,177,000 1,108,000                               
        preferred stock
                                                              9,496,000  9,496,000 9,496,000 9,496,000  9,496,000 9,496,000 9,496,000  9,496,000 9,496,000 9,496,000  9,496,000 9,496,000 9,496,000  9,496,000 9,496,000 9,496,000  9,496,000 9,496,000 9,496,000                  
        debt — current
                                                             3,692,000                                           
        debt — non-current
                                                             3,717,000                                           
        capital lease obligations—current
                                                                                                        
        capital lease obligations—non-current
                                                                                                        
        preferred stock, 0.001 par value 5,000 shares authorized, issuable in series; 3 shares issued and outstanding at both december 31, 2011 and 2010; aggregate liquidation preference of 9,496 at december 31, 2011 and 2010
                                                               9,496,000                                         
        current portion of long-term debt
                                                                 1,876,000 1,811,000 1,747,000 1,264,000 797,000 367,000                                  
        current portion of capital lease obligations
                                                                 11,000 10,000 10,000 10,000 9,000 9,000 9,000        30,000    84,000    67,000      3,000 7,000 28,000 34,000 36,000 34,000 33,000 31,000 30,000 29,000 29,000 
        long-term debt
                                                                4,910,000 2,159,000 2,654,000 3,131,000 3,591,000 4,036,000 4,511,000                                  
        long-term portion of capital lease obligations
                                                                  3,000 6,000 8,000 11,000                                   
        purchased intangible
                                                                  1,899,000                                      
        non-current liabilities
                                                                                                        
        stockholders’ equity
                                                                                                        
        purchased intangibles
                                                                   1,950,000                                     
        accrued restructuring
                                                                      24,000 113,000 209,000 361,000 652,000                              
        preferred stock, 0.001 par value: 5,000 shares authorized, issuable in series; 3 shares issued and outstanding at december 31, 2010, and 2009; aggregate liquidation preference of 9,496 at december 31, 2010, and 2009
                                                                   9,496,000                                     
        long-term investment in related party
                                                                        2,340,000 2,203,000 2,164,000 2,329,000 1,988,000 1,983,000 2,120,000 1,874,000 1,832,000 1,725,000 11,175,000                      
        long term portion of capital lease obligations
                                                                       15,000        2,000    32,000    68,000                 
        other long-term liabilities
                                                                       115,000    163,000                             
        preferred stock, 0.001 par value: 5,000 shares authorized, issuable in series; 3 shares issued and outstanding at december 31, 2009, and 2008; aggregate liquidation preference of 9,496 at december 31, 2009, and 2008
                                                                       9,496,000                                 
        capital lease obligations
                                                                        8,000    9,000                            
        preferred stock, 0.001 par value: 5,000 shares authorized, issuable in series; 3 shares issued and outstanding at december 31, 2008, and 2007; aggregate liquidation preference of 9,496 at december 31, 2008, and 2007
                                                                           9,496,000                             
        capital lease obligation
                                                                             17,000 24,000  32,000 48,000 72,000  41,000 65,000 99,000                  
        deferred gain
                                                                                  91,000 586,000 3,520,000 5,171,000 5,753,000                  
        preferred stock, 0.001 par value: 5,000 shares authorized, issuable in series; 3 shares issued and outstanding at december 31, 2007, and 2006; aggregate liquidation preference of 9,496 at december 31, 2007, and 2006
                                                                               9,496,000                         
        accumulated other comprehensive
                                                                                      -162,000                  
        long-term investments
                                                                                   11,175,000 6,175,000 6,175,000 6,175,000 6,175,000    1,175,000 1,175,000            
        current loan and interest payable
                                                                                       4,826,000                 
        preferred stock, 0.001 par value: issuable in series; 3 shares issued and outstanding at december 31, 2006, and 2005; aggregate liquidation preference of 9,496 at december 31, 2006, and 2005
                                                                                   9,496,000                     
        accounts receivable and other current assets
                                                                                    9,624,000 5,344,000 7,065,000 5,200,000 5,237,000 4,460,000 4,460,000 4,533,000 4,603,000 6,034,000 7,313,000 4,680,000 4,287,000 3,764,000       
        furniture and equipment, net of depreciation and amortization
                                                                                    1,517,000 1,559,000 1,547,000                  
        current portion of capital lease obligation
                                                                                    100,000 102,000                   
        inventory
                                                                                      2,068,000                  
        furniture and equipment at cost:
                                                                                                        
        laboratory and office equipment
                                                                                       6,306,000    5,768,000             
        leasehold improvements
                                                                                       7,453,000    7,173,000             
        furniture and equipment at cost: - sum
                                                                                       13,759,000    12,941,000             
        less accumulated depreciation and amortization
                                                                                       12,524,000    11,994,000             
        net furniture and equipment
                                                                                       1,235,000    947,000             
        accrued compensation and related expenses
                                                                                       2,676,000    2,749,000             
        accrued contract and other expenses
                                                                                       2,521,000                 
        deferred gain on loan settlement
                                                                                           22,089,000             
        long term debt payable to a related party
                                                                                          4,557,000 4,500,000             
        preferred stock, 0.001 par value: issuable in series; 3 shares issued and outstanding at december 31, 2005, and 2004; aggregate liquidation preference of 9,496 at december 31, 2005, and 2004
                                                                                       9,496,000                 
        furniture and equipment, net of depreciation
                                                                                        1,065,000 890,000 953,000  837,000 1,183,000 1,867,000 3,388,000 4,092,000 4,838,000 6,164,000 6,274,000 5,385,000 2,717,000 2,904,000 2,906,000 
        accounts payable to related party
                                                                                        311,000                
        accrued expenses
                                                                                        4,657,000 3,947,000 3,303,000  3,905,000 5,960,000 4,179,000 4,802,000 5,295,000 4,437,000 5,979,000 6,473,000 7,471,000 5,169,000 7,604,000 6,458,000 
        long-term debt and accrued interest
                                                                                        4,736,000 4,646,000               
        accounts receivable from related parties
                                                                                          47,000 4,000  59,000 29,000 25,000 6,000        
        accounts payable to a related party
                                                                                           196,000 682,000 2,500,000 2,099,000 6,180,000 7,142,000 7,441,000 8,897,000 8,410,000 5,121,000 7,873,000 3,288,000 1,828,000 
        current loan and interest payable to a related party
                                                                                           34,500,000             
        accrued contract research expenses
                                                                                           587,000             
        other accrued expenses
                                                                                           1,471,000             
        preferred stock, 0.001 par value: issuable in series; 3,327 shares issued and outstanding at december 31, 2004 and 2003; aggregate liquidation preference of 9,496 at december 31, 2004 and 2003
                                                                                           9,496,000             
        accounts receivable from a related party
                                                                                            15,000     21,000 55,000 5,028,000 28,000 63,000 149,000 177,000 
        loan and interest payable to a related party
                                                                                            60,109,000 58,694,000 57,272,000 54,417,000         
        capital lease obligations, less current portion
                                                                                                 6,000 25,000 34,000 45,000 59,000 67,000 74,000 
        long-term debt, payable to a related party
                                                                                                52,917,000 51,417,000       
        redeemable convertible preferred stock
                                                                                                   5,000,000 5,000,000 5,000,000 5,000,000 5,000,000 
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 2009-12-31 2009-09-30 2009-06-30 2009-03-31 2008-12-31 2008-09-30 2008-06-30 2008-03-31 2007-12-31 2007-09-30 2007-06-30 2007-03-31 2006-12-31 2006-09-30 2006-06-30 2006-03-31 2005-12-31 2005-09-30 2005-06-30 2005-03-31 2004-12-31 2004-09-30 2004-06-30 2004-03-31 2003-09-30 2003-06-30 2003-03-31 2002-09-30 2002-06-30 2002-03-31 2001-09-30 2001-06-30 2001-03-31 
                                                                                                          
          operating activities
                                                                                                          
          net loss
        -1,648,000 -2,184,000 -20,000 -5,715,000 -7,718,000 -2,562,000 -2,934,000 -5,775,000 -9,690,000 -1,389,000 -7,286,000 -13,331,000 -15,641,000 -13,625,000 -8,521,000 -8,395,000 -12,284,000 -9,121,000 -12,437,000 -15,361,000 -17,457,000 -14,381,000 -14,139,000 -14,871,000 -16,466,000 -16,923,000 -17,967,000 -17,562,000 -18,792,000 -16,205,000 -14,192,000 -13,282,000 -13,885,000 -11,486,000 -13,418,000 -17,083,000 -18,598,000 -13,501,000 -14,376,000 -18,166,000 -16,863,000 -14,756,000 -15,680,000 -15,972,000 -9,460,000 -20,182,000 -10,759,000 -7,589,000 -225,000 -5,860,000 -20,501,000 -6,724,000 -10,252,000 -1,716,000 -3,460,000 -1,907,000 -8,834,000 -7,997,000 2,338,000 -6,313,000 -5,010,000 -2,630,000 -3,832,000 -5,427,000 -5,022,000 -4,889,000 -5,637,000 -6,212,000 -7,397,000 -5,978,000 -8,818,000 -9,093,000 -5,292,000  -9,151,000           -5,352,000 -5,060,000 -11,547,000 -9,194,000 -14,208,000 -16,772,000 -17,159,000     -11,975,000 -11,165,000 
          adjustments to reconcile net loss to net cash from operating activities:
                                                                                                          
          depreciation and amortization
        447,000 393,000 382,000 344,000 307,000 332,000 412,000 480,000 631,000 647,000 677,000 640,000 635,000 649,000 708,000 762,000 865,000 812,000 765,000 777,000 794,000 811,000 810,000 782,000 706,000 622,000 -127,000 1,179,000 729,000 336,000 321,000 375,000 413,000 452,000 455,000 435,000 469,000 423,000 430,000 488,000 476,000 470,000 394,000 392,000 443,000 426,000 374,000 290,000 325,000 147,000 127,000 116,000 167,000 162,000 180,000 194,000 208,000 161,000 241,000 251,000 269,000 284,000 192,000 181,000 188,000 357,000 188,000 181,000 189,000 206,000 187,000 148,000 110,000 184,000 170,000 207,000 213,000 189,000 183,000 180,000 164,000 148,000 139,000 170,000 195,000 200,000 316,000 814,000 822,000 825,000 822,000 821,000 791,000 564,000 330,000 295,000 294,000 280,000 
          stock-based compensation
        4,904,000 4,927,000 5,624,000 5,681,000 6,635,000 5,504,000 5,830,000 5,678,000 5,855,000 4,903,000 3,979,000 5,720,000 5,669,000 7,255,000 5,768,000 5,007,000 6,426,000 6,538,000 5,892,000 5,808,000 5,333,000 4,723,000 4,846,000 4,706,000 3,754,000 3,700,000 3,595,000 3,139,000 2,878,000 2,815,000 2,671,000 2,593,000 2,315,000 2,347,000 2,391,000 2,470,000 2,147,000 2,099,000 2,104,000 2,086,000 1,776,000 1,818,000 1,733,000 1,705,000 1,474,000 1,389,000 1,478,000 1,340,000 946,000 853,000 861,000 841,000 713,000 630,000 695,000 674,000 542,000 464,000 463,000 451,000 472,000 528,000 502,000   507,000 493,000                    127,000            
          non-cash operating lease cost
        667,000 615,000 581,000 717,000 619,000 553,000 701,000 633,000 595,000 745,000 505,000 587,000 471,000 547,000 324,000 308,000 396,000 361,000 355,000 345,000 361,000 384,000 343,000 319,000 300,000                                                                          
          net loss on sale of available-for-sale securities
        1,000 -11,000 3,000   3,000 -1,000 3,000 2,000     6,000 11,000 65,000 26,000     -22,000                                                                             
          unrealized loss on investments
        105,000    40,000                                                                                              
          non-cash interest expense
        98,000 100,000 101,000 99,000 98,000 101,000 92,000 99,000 106,000 84,000 91,000 81,000 118,000 -831,000 519,000 457,000 464,000 468,000 299,000 377,000 104,000 120,000 121,000 118,000 119,000 43,000 96,000 50,000 197,000 356,000 355,000 268,000 269,000 269,000 -3,000 90,000 195,000 197,000 217,000 303,000 300,000 278,000 91,000 75,000 64,000 66,000       4,000 5,000 5,000 4,000 6,000   44,000 49,000 51,000 50,000                                    
          foreign currency remeasurement loss
        -277,000 143,000 -361,000 11,000 497,000     711,000 -366,000 -263,000 -767,000 1,371,000 -31,000 284,000 287,000 125,000 189,000                                                                                
          changes in operating assets and liabilities:
                                                                                                          
          accounts receivable
        869,000 -608,000 1,438,000 -4,887,000 3,661,000 -5,624,000 -491,000 -1,219,000 12,838,000 -10,789,000 -2,477,000 3,007,000 9,157,000 -6,032,000 -1,324,000 -1,280,000 -564,000 -2,527,000 446,000 -5,047,000 2,913,000 -4,930,000 1,388,000 541,000 -1,283,000 -2,380,000 -1,070,000 324,000 -5,004,000 1,724,000 912,000 -899,000 1,926,000 -1,939,000 -1,886,000 -3,007,000 1,285,000 573,000 -2,292,000 -1,063,000 1,708,000 -148,000 -222,000 -271,000 340,000 1,873,000 -2,888,000 465,000 1,182,000 900,000 -1,157,000 -1,135,000 -289,000 -494,000 -225,000 1,297,000 1,074,000 -1,313,000 -363,000 380,000 -8,000 -1,280,000 -45,000 172,000 -14,000 -332,000 9,000 213,000 806,000 -34,000 259,000 296,000 139,000  1,517,000 911,000 -4,025,000  -3,906,000 5,934,000 -5,796,000                  
          inventories
        -5,815,000 -3,176,000 704,000 -5,877,000 -6,333,000 -990,000 1,742,000 4,684,000 1,594,000 4,572,000 -8,174,000 -5,349,000 -5,996,000 751,000 203,000 -1,888,000 -834,000 -7,480,000 -4,124,000 -6,970,000 -1,036,000 -3,955,000 -1,037,000 3,188,000 -2,226,000 1,416,000 -3,482,000 -1,691,000 -2,286,000 -237,000 -415,000 234,000 1,224,000 -292,000 -2,037,000 625,000 -388,000 -349,000 -114,000 -830,000 -488,000 2,021,000 858,000 2,332,000 -1,220,000 3,665,000 779,000 -2,528,000 1,117,000 -468,000 -4,000 283,000 -1,624,000 -502,000 -309,000 -470,000 -2,459,000 3,147,000 377,000 -842,000 -3,169,000 1,377,000 -797,000 557,000 883,000 647,000 1,366,000 1,350,000 4,000 -801,000 1,683,000 -2,468,000 -2,461,000 -3,119,000 147,000 -1,513,000 -744,000  60,000                    
          prepaid and other assets
        542,000 442,000 -1,258,000 1,501,000 -2,312,000 -837,000 -1,150,000 -919,000 -119,000 515,000 -1,739,000 1,665,000 -1,435,000 -341,000 -168,000                                                                                    
          accounts payable
        4,141,000 2,363,000 -4,480,000 2,805,000 5,037,000 6,348,000 -1,004,000 -683,000 -6,138,000 -15,424,000 1,556,000 1,702,000 4,831,000 465,000 643,000 -1,892,000 -4,121,000 9,707,000 -4,892,000 8,939,000 -1,550,000 4,992,000 430,000 -878,000 -2,308,000 2,012,000 -224,000 632,000 2,597,000 2,663,000 2,866,000 276,000 -122,000 -1,535,000 2,937,000 887,000 198,000 1,699,000 -340,000 907,000 995,000 -781,000 1,091,000 -4,660,000 484,000 582,000 1,070,000 -444,000 -2,181,000 1,598,000 -959,000 1,148,000 -3,299,000 1,486,000 2,192,000 -642,000 -530,000 900,000 -902,000 -549,000 2,001,000                                      
          accrued liabilities and other non-current liabilities
        -7,529,000 4,209,000 -787,000 3,279,000 -2,426,000 2,688,000 235,000 -1,531,000 -3,590,000 -724,000 1,559,000 -3,309,000 -6,596,000 6,878,000 -81,000 534,000 -8,594,000 -1,469,000 2,567,000 3,155,000 -4,863,000 4,674,000 2,730,000 -288,000 -4,356,000 2,672,000 2,033,000 1,399,000 -4,809,000 1,585,000 3,904,000 1,894,000 -1,341,000 970,000                                                                 
          deferred revenue
        446,000 -1,007,000 70,000 -238,000 1,051,000 -423,000 726,000 -1,071,000 165,000                               137,000 52,000 232,000 -298,000 233,000 23,000 -110,000 294,000 -13,000 98,000 70,000 -42,000 -21,000 97,000 -639,000 580,000 -61,000 86,000 37,000 -49,000 -38,000 -87,000 15,000 21,000 -163,000 30,000 42,000 -356,000 249,000 -35,000 360,000 25,000 -229,000 -1,215,000 1,465,000 7,000 -94,000 126,000 2,946,000 -2,053,000 -3,465,000 -3,563,000     9,566,000 2,106,000 943,000 27,000       229,000 -27,000 964,000 
          net cash from operating activities
        -3,049,000 6,200,000 1,927,000 -2,446,000 -844,000 4,929,000 4,070,000 401,000 1,959,000 -15,183,000 -10,489,000 -8,996,000 -8,500,000 -1,756,000 -2,058,000 -345,000 -21,456,000 -1,222,000 -6,582,000 -8,142,000 -17,976,000 -8,458,000 -4,679,000 -7,804,000 -19,802,000 -8,561,000 -22,217,000 -12,882,000 -22,178,000 -7,095,000 -4,896,000 -8,930,000 -10,325,000 -10,035,000 -12,853,000 -12,999,000 -16,348,000 -9,711,000 -16,251,000 -14,524,000 -13,043,000 -8,785,000 -11,860,000 -14,733,000 -15,751,000 -8,634,000 -11,741,000 -9,611,000 -9,825,000 -6,664,000 -6,092,000 -5,689,000 -8,352,000 -2,875,000 -1,752,000 -5,386,000 -3,904,000 -1,146,000 -3,449,000 -5,979,000 -5,058,000 -4,365,000 -1,901,000 -2,005,000 -5,840,000 -2,837,000 -2,333,000 -2,486,000 -7,008,000 -6,458,000 -9,526,000 -7,862,000 -10,699,000 -12,745,000 -5,648,000 -5,048,000 -13,961,000 -307,000 -6,624,000 -6,239,000 -1,515,000                 -10,861,000 
          investing activities
                                                                                                          
          capital expenditures
        -233,000 -1,307,000 -1,833,000 -477,000 -112,000 -976,000 -721,000 -41,000 -1,099,000 6,000 -2,635,000 -444,000 -1,524,000 -1,235,000 -574,000 -78,000 -113,000 -464,000 -221,000 -32,000 -193,000 -466,000 -242,000 -455,000 -452,000 -475,000 -1,944,000 -3,201,000 -3,315,000 -520,000 -479,000 -93,000 -52,000 1,000 -1,000 -168,000 -185,000 -204,000 -241,000 -75,000 -43,000 -161,000 -236,000 -266,000 -59,000 -73,000 -604,000 -590,000 -839,000 -223,000 -260,000 -154,000 -26,000 16,000 -34,000 -61,000 -2,000 -51,000 -106,000 -806,000 -735,000 -62,000 -40,000 -43,000 -57,000 2,000 -466,000 -220,000 -116,000 -108,000 -136,000 -141,000 -489,000 -179,000                 -192,000 
          free cash flows
        -3,282,000 4,893,000 94,000 -2,923,000 -956,000 3,953,000 3,349,000 360,000 860,000 -15,177,000 -13,124,000 -9,440,000 -10,024,000 -2,991,000 -2,632,000 -423,000 -21,569,000 -1,686,000 -6,803,000 -8,174,000 -18,169,000 -8,924,000 -4,921,000 -8,259,000 -20,254,000 -9,036,000 -24,161,000 -16,083,000 -25,493,000 -7,615,000 -5,375,000 -9,023,000 -10,377,000 -10,034,000 -12,854,000 -13,167,000 -16,533,000 -9,915,000 -16,492,000 -14,599,000 -13,086,000 -8,946,000 -12,096,000 -14,999,000 -15,810,000 -8,707,000 -12,345,000 -10,201,000 -10,664,000 -6,887,000 -6,352,000 -5,843,000 -8,378,000 -2,859,000 -1,786,000 -5,447,000 -3,906,000 -1,146,000 -3,449,000 -5,979,000 -5,109,000 -4,471,000 -2,707,000 -2,740,000 -5,902,000 -2,837,000 -2,373,000 -2,529,000 -7,065,000 -6,458,000 -9,524,000 -8,328,000 -10,919,000 -12,745,000 -5,764,000 -5,156,000 -14,097,000 -307,000 -6,765,000 -6,728,000 -1,694,000                 -11,053,000 
          purchases of investments
        -8,410,000 -15,012,000 -7,288,000 -12,513,000 -7,964,000 -24,234,000 -5,645,000 -12,977,000 -119,000 -82,000 -53,000 -1,789,000 -562,000 -6,983,000 -9,441,000 -12,574,000 -642,000 -49,934,000 -106,000 -111,000 -1,915,000 -4,765,000 -17,157,000 -8,351,000 -68,520,000 -9,151,000 -7,028,000 -26,728,000 -1,000,000 -248,000 -4,991,000 -18,521,000 -56,941,000 -18,609,000 -29,434,000 -10,591,000 -10,158,000 -11,051,000 -1,200,000 -20,016,000 -50,544,000 -12,146,000 -8,278,000 -1,000 -69,982,000 -11,174,000                                                     
          proceeds from maturities and sale of investments
        18,503,000 14,941,000 6,612,000 11,901,000 6,887,000 17,924,000 11,183,000 5,911,000 2,664,000 8,292,000 2,413,000 4,562,000 440,000 15,601,000 7,949,000 7,177,000 9,377,000 10,108,000 22,056,000 10,000,000 23,500,000 12,833,000 12,019,000 7,211,000 18,787,000 19,027,000 19,000,000 25,500,000 17,500,000 7,995,000 6,000,000 11,752,000 12,250,000 14,000,000 17,101,000 22,447,000 16,018,000                                                              
          net cash from investing activities
        9,860,000 -1,378,000 -2,509,000 -1,089,000 -1,189,000 -7,286,000 4,817,000 -7,107,000 1,446,000 8,216,000 -275,000 2,329,000 -1,646,000 7,383,000 -2,066,000 -5,475,000 8,622,000 -40,290,000 21,729,000 9,857,000 21,392,000 7,602,000 -5,380,000 -1,595,000 -50,185,000 9,401,000 10,028,000 -4,429,000 13,185,000 7,227,000 530,000 -6,862,000 -44,743,000 -4,608,000 -12,334,000 11,688,000 5,675,000 18,661,000 12,556,000 -6,092,000 -45,049,000 22,905,000 26,485,000 17,616,000 -65,594,000 -3,862,000 -4,863,000 2,377,000 3,001,000 559,000 -29,423,000 -167,000 -26,000 14,000 -35,000 30,000 196,000 273,000 109,000 18,000 163,000 724,000 -515,000 -705,000 409,000 651,000 1,851,000 3,293,000 3,645,000 1,491,000 2,362,000 7,933,000 12,107,000 -6,287,000 9,869,000 -873,000 6,593,000 -20,412,000 -7,666,000 10,201,000 9,937,000 4,070,000 3,094,000 3,800,000 4,400,000 25,321,000   13,006,000   712,000     1,677,000 7,295,000 
          financing activities
                                                                                                          
          net proceeds from equity incentives
        263,000 269,000 326,000 363,000 441,000 433,000 492,000 490,000 1,082,000 377,000 2,135,000 4,285,000 2,991,000 876,000 1,218,000 4,766,000 4,187,000 1,604,000 1,193,000 356,000 1,584,000 560,000 710,000 698,000 2,238,000 3,617,000 1,295,000  369,000 1,630,000 422,000              404,000                                                
          net costs from public offerings
         52,000 -31,000 -56,000 -30,000 -42,000    -65,000 -72,000                                                                                      
          net proceeds from revolving line of credit
        929,000    801,000                     24,000 497,000                                                                        
          net cash from financing activities
        1,192,000 -1,031,000 320,000 -129,000 1,071,000 746,000 60,000 -1,403,000 5,561,000 1,183,000 7,602,000 -173,000 2,061,000 457,000 1,084,000 202,000 2,449,000 12,098,000 4,581,000 127,000 17,488,000 8,287,000 4,171,000 10,641,000 68,684,000 9,484,000 13,066,000 11,804,000 9,133,000 6,399,000 12,388,000 15,137,000 58,827,000 11,332,000 21,902,000 10,645,000 -879,000 302,000 8,871,000 7,529,000 7,865,000 6,103,000 1,111,000 14,242,000 76,498,000 12,934,000 10,385,000 11,804,000 1,331,000 11,235,000 1,669,000 -5,106,000 50,845,000 2,896,000 1,781,000 574,000 9,660,000 11,609,000 934,000 -471,000 -454,000 20,705,000 161,000 36,000 4,957,000 7,000 12,158,000 43,000 -36,000 65,000 591,000 710,000 671,000 478,000 16,000 273,000 24,440,000 160,000 -53,000 38,585,000     93,000 -4,000 118,000 327,000      764,000 76,435,000 907,000 
          effect of exchange rates on cash, cash equivalents, and restricted cash
        -122,000 -60,000 210,000 186,000 -237,000 152,000 -16,000 -90,000 -16,000 -107,000 -121,000 116,000 401,000 -410,000 -434,000 -284,000 -280,000 -276,000                                                                                
          net increase in cash, cash equivalents, and restricted cash
        7,881,000 3,791,000 -322,000 -3,454,000 -776,000 -1,848,000 9,099,000 -8,125,000 8,876,000     6,485,000 -3,450,000                                                                                    
          cash, cash equivalents, and restricted cash, beginning of period
        20,600,000 21,361,000 13,359,000 37,358,000                                                                                    
          cash, cash equivalents, and restricted cash, end of period
        28,481,000 3,791,000 -322,000 -3,454,000 20,585,000 -1,848,000 9,099,000 -8,125,000 22,235,000 -5,800,000 -3,269,000 -6,961,000 29,389,000 6,485,000 -3,450,000                                                                                    
          unrealized gain on investments
         -6,000 -70,000   83,000 -108,000 6,000 -116,000 -169,000 114,000 -62,000 -53,000 -80,000 103,000 233,000 -820,000 -25,000 7,000 -41,000 -208,000                                                                              
          loss on disposal of fixed assets
             3,000                                                                                         
          impairment charges for facilities consolidation
                 1,493,000                                                                                        
          net (payments on) proceeds from revolving line of credit
                                                                                                          
          proceeds from loans, net of issuance costs
                5,000,000                                                                                          
          supplemental disclosure of cash flow information:
                                                                                                          
          cash paid for interest
                                                         52,000 39,000 125,000 78,000 130,000 126,000 121,000 83,000 189,000 434,000 239,000 162,000 226,000 225,000                                    
          cash paid for income taxes
                                                            26,000                                              
          net proceeds from (payment on) revolving line of credit
          -1,000                                                                                                
          changes in valuation of warrant investment
                      9,000 -45,000 281,000 337,000 -83,000 -182,000 -220,000                                                                              
          foreign currency remeasurement gain
              20,000 16,000 -177,000                                                                                          
          net (payment on) proceeds from revolving line of credit
                              32,000                                                                            
          proceeds from loans
                        15,000,000                                                                           
          debt issuance costs
                  -68,000                                                                                        
          net (payment on) proceeds on revolving line of credit
                                                                                                          
          net proceeds on revolving line of credit
                120,000 1,221,000 2,237,000 -1,458,000 3,091,000 29,000 -50,000 -81,000 314,000 4,711,000 657,000 -609,000 1,422,000                                                                              
          loss, net on sale of available-for-sale securities
                                                                                                          
          impairment of long-lived assets
                      542,000                                                                                  
          net (costs) proceeds from public offerings
                                                                                                          
          contribution from noncontrolling interest
                                                                                                         
          net gain on sale of available-for-sale securities
                  4,000 43,000 3,000                                                                                      
          deferred product revenue
                  -425,000 -332,000 1,104,000 -165,000 -221,000 -283,000 585,000 -71,000 -127,000 -185,000 479,000 16,000 -145,000 -436,000 572,000 9,000 -104,000 -98,000 265,000 -35,000 -143,000 30,000 186,000 -249,000 281,000 -80,000 313,000 -751,000                                                             
          net decrease in cash, cash equivalents, and restricted cash
                  -3,269,000 -6,961,000 -7,969,000                                                                                      
          repayment of loans
                    -1,450,000                                                                                      
          impairment (unrealized gain) in private company investment
                                                                                                          
          offering costs from public offerings
                      52,000                                                                                    
          other assets
                        -4,111,000 729,000 4,589,000 46,000 -2,626,000 -742,000 -21,000 -979,000 1,119,000 -89,000 59,000 -348,000 2,165,000 -20,000 -1,137,000 -112,000 -1,475,000 1,486,000 -1,083,000 1,014,000 -310,000 973,000 -81,000 648,000 -213,000 577,000 63,000 855,000 -116,000 1,205,000 -2,410,000 314,000 -764,000 185,000 -338,000 -418,000 910,000 343,000 -1,992,000 110,000 -124,000 72,000 -218,000 326,000 -193,000 248,000 59,000 -262,000 54,000 26,000 -191,000 236,000 74,000 -696,000 217,000 299,000 752,000 -1,532,000 -225,000 222,000 544,000 651,000 -376,000 -4,209,000 3,907,000 -161,000    -61,000 107,000 25,000         1,000 
          net increase in cash, cash equivalents and restricted cash
                        -10,669,000 -29,694,000 19,452,000 1,479,000 20,904,000    -1,303,000 10,324,000 877,000 -5,507,000 140,000 6,531,000 8,022,000 -655,000 3,759,000                                                                  
          cash, cash equivalents and restricted cash, beginning of period
                        51,044,000 38,903,000 37,421,000 31,587,000  13,930,000  22,744,000                                                              
          cash, cash equivalents and restricted cash, end of period
                        40,375,000 -29,694,000 19,452,000 1,479,000 59,807,000 7,431,000 -5,888,000 1,242,000 36,118,000 10,324,000 877,000 -5,507,000 31,727,000  8,022,000 -655,000 17,689,000  -3,285,000 9,334,000 11,192,000                                                              
          loss on disposal of property and equipment
                                 1,000                                                                      
          manufacturing and development obligations
                                 -6,250,000 80,000 -118,000 -79,000 -39,000 -312,000 164,000 80,000 181,000 343,000 76,000 -310,000 -2,176,000 -158,000 -924,000                                                          
          net proceeds from public offerings
                             -13,000 -48,000 8,900,000 67,695,000                                                                          
          non-cash investing activities:
                                                                                                          
          non-cash leasehold improvements
                                                                                                          
          loss on sale of available-for-sale securities
                               -6,000 267,000                                                                          
          net (offering costs) proceeds from public offerings
                          -67,000                                                                                
          net (payments for) proceeds from public offerings
                            -152,000                                                                              
          repayment of debt
                                 -24,000 -35,000 -35,000 -31,010,000 -34,000 -34,000 -33,000 -32,000 -32,000 -17,663,000 -659,000 -1,271,000 -31,000 -531,000 -28,000 -32,000 -28,000 -29,000 -28,000 -28,000                                                      
          net decrease in cash, cash equivalents and restricted cash
                             7,431,000 -5,888,000            -3,285,000 9,334,000 -11,552,000                                                              
          net payment on revolving line of credit
                                -204,000                                                                          
          non-cash tax expense from realized gain on available-for-sale securities
                                                                                                          
          gain on sale of investment in marketable equity securities
                                         -3,448,000 -18,000                                                              
          net proceeds from public offering
                                 9,128,000 11,020,000   5,735,000 10,184,000   11,357,000 9,196,000   -25,000 7,599,000 7,348,000 7,199,000 -27,000 3,000 -203,000 75,527,000 11,639,000 3,002,000 3,816,000 31,000 10,444,000 -190,000 -331,000 51,502,000 3,403,000 947,000 264,000 9,612,000                                          
          non-cash purchases of capital expenditures
                                                                                                          
          non-cash lease expense
                                                                                                          
          proceeds from loans, net of discount
                                    39,433,000                                                                     
          deferred income taxes
                                     2,000 1,000 1,000 -138,000 7,000 5,000 7,000 10,000 9,000 9,000 -5,000 5,000 6,000 1,000 7,000 6,000 7,000 6,000 7,000 7,000 6,000 7,000                                              
          cash, cash equivalents and restricted cash, beginning of year
                                                                                                          
          cash, cash equivalents and restricted cash, end of year
                                                                                                          
          non-cash tax expense from other realized gain on available-for-sale securities
                                                                                                          
          non-cash tax expense from other unrealized loss on available-for-sale securities
                                             -456,000 934,000 768,000                                                          
          net proceeds from (payments for) public offering
                                        57,564,000                                                                  
          changes in valuation of warrant liability
                                                                                                          
          non-cash deferred manufacturing and development expense
                                                                                                          
          non-cash tax expense from other unrealized gain on available-for-sale securities
                                                                                                          
          net proceeds from equity incentives and warrants
                                             358,000 1,803,000                                                            
          supplemental disclosures:
                                                                                                          
          unpaid manufacturing and development obligation
                                                                                                          
          bad debt expense
                                                                                                          
          accrued liabilities
                                           267,000 -1,724,000 1,072,000 716,000 181,000 -639,000 1,734,000 1,163,000 -50,000 -1,488,000 -4,110,000 1,985,000 2,038,000 -1,295,000 -2,327,000 3,458,000 905,000 85,000 -248,000 1,456,000 -911,000 1,674,000 136,000 200,000 -21,000 -651,000                                      
          net (payments for) proceeds from public offering
                                            -30,000                                                              
          non-cash tax benefit from other unrealized gain on available-for-sale securities
                                                                                                          
          proceeds from sale of fixed assets
                                                                                                          
          proceeds from maturities of investments
                                              14,000,000 14,000,000 5,500,000 35,201,000 35,000,000   7,610,000                                                     
          restricted cash
                                              -3,000 -1,000 38,000 11,000 -1,000 -161,000 47,000                                                      
          net increase in cash and cash equivalents
                                              5,176,000   20,223,000 15,736,000 17,125,000 -4,847,000   4,570,000 -5,493,000 5,130,000 -33,846,000 -10,962,000 42,467,000 35,000 -6,000 -4,782,000 5,952,000     17,064,000    -2,179,000 11,676,000     662,000 2,118,000 -18,361,000 4,699,000 -5,905,000 -7,095,000    47,007,000        2,578,000 -39,950,000      -39,067,000   
          cash and cash equivalents, beginning of period
                                                 22,781,000  29,485,000 26,696,000 25,497,000 28,948,000 17,287,000 10,303,000 19,625,000 46,287,000 5,780,000 -324,000 39,493,000 23,165,000 22,435,000 64,503,000 71,871,000 
          cash and cash equivalents, end of period
                                              5,176,000    15,736,000 17,125,000 17,934,000  -6,219,000 4,570,000 23,992,000 5,130,000 -33,846,000 -10,962,000 69,163,000 35,000 -6,000 -4,782,000 31,449,000 10,736,000 -2,406,000 -6,432,000 23,599,000 17,064,000 -2,255,000 -2,674,000 16,813,000 -2,179,000 11,676,000 807,000 6,983,000 -5,003,000 -7,099,000 662,000 21,743,000 -18,361,000 4,699,000 -5,905,000 39,192,000 3,721,000 -14,130,000 3,909,000 52,787,000 375,000 472,000 97,000 4,836,000 31,555,000 -286,000 -17,843,000 25,743,000 -39,950,000 37,481,000 55,347,000 15,637,000 -21,465,000 47,956,000 -39,067,000 69,156,000 69,212,000 
          net proceeds from the issuance of common stock in connection with equity incentive plans
                                                698,000                                                          
          net decrease in cash and cash equivalents
                                                -50,227,000                  -2,406,000 -6,432,000 -5,349,000   -2,674,000 -474,000    -3,320,000                              
          cash and cash equivalents, beginning of year
                                                71,018,000                                                          
          cash and cash equivalents, end of year
                                                20,791,000                                                          
          tax benefit from other unrealized gain on available-for-sale securities
                                                 -1,791,000 51,000                                                        
          net proceeds from exercise/purchase of equity incentives and warrants
                                                                                                          
          proceeds from debt, net of discount
                                                                                                          
          non-cash settlement of warranty claim
                                                                                                        
          gain from revaluation of warrant liability
                                                                                                          
          proceeds from sales of certain other assets
                                                                                                          
          net proceeds from equity incentive plans and warrants
                                                  1,137,000                                                        
          changes in revaluation of warrant liability
                                                   2,707,000 -6,296,000  -1,738,000 -3,491,000 -9,034,000  12,416,000 -686,000 5,073,000 -1,973,000 -873,000                                            
          proceds from maturities of investments
                                                    4,400,000                                                      
          net proceeds from equity incentive plans
                                                    999,000    1,425,000    152,000    77,000                                          
          non-cash conversion of preferred stock to common stock
                                                                                                        
          proceeds from sales (purchases) of certain assets and other
                                                                                                          
          net proceeds from equity incentives and exercise of warrants
                                                      7,410,000                                                    
          proceeds from term loan, net of discount and revolving line of credit
                                                                                                         
          payments on debt, revolving line of credit and landlord provided leasehold incentives
                                                      -27,000 -3,294,000 -125,000    -1,335,000                                              
          changes in operating assets and liabilities, net of effects of acquired business:
                                                                                                          
          purchases of investments and certain other assets
                                                       -3,032,000 -460,000                                                  
          maturities of investments
                                                       5,999,000 4,300,000     87,000 200,000 169,000 156,000 123,000 218,000                                      
          proceeds from revolving line of credit
                                                         1,094,000 1,482,000 526,000 591,000 1,044,000                                            
          changes in valuation of outstanding warrant liability
                                                                                                          
          (interest expense paid) non-cash interest expense
                                                                                                          
          loss on disposal of equipment
                                                         -40,000                                                 
          purchases of furniture, equipment and leasehold improvements
                                                         -223,000 -260,000 -154,000 -26,000 16,000 -34,000 -61,000 -2,000    -51,000 -106,000 -806,000 -735,000 -62,000  -40,000 -43,000 -57,000  2,000 -466,000 -220,000  -116,000 -108,000 -136,000  -141,000 -489,000 -179,000                 -192,000 
          (purchases) sales of certain other assets
                                                         -1,000 -1,000                                                
          net proceeds from equity incentives and the exercise of warrants
                                                             34,000                                             
          payments on revolving line of credit
                                                             -684,000                                             
          payments on debt and landlord provided leasehold incentives
                                                         1,534,000 -27,000   -448,000 -29,000 -31,000 -29,000                                          
          (purchases) maturities of investments
                                                                                                          
          proceeds from warrant exercises
                                                                                                          
          loss on disposal
                                                           56,000                                              
          purchases of certain other assets
                                                                -2,000                                          
          gain on non-controlling equity interest
                                                                                                          
          accrued restructuring
                                                                     -24,000 -89,000  -152,000 -291,000 652,000                              
          sales (purchases) of certain other assets
                                                                                                          
          sales of investments
                                                                                                          
          proceeds from landlord provided leasehold incentives
                                                                                                          
          common stock issued in connection with the acquisition of certain assets of bioone
                                                                                                          
          gain on sale of fixed assets
                                                              -1,000 -8,000                                          
          purchases (sales) of certain other assets
                                                              -1,000                                            
          loss from revaluation of warrant liability
                                                                4,461,000  -5,439,000      962,000                                  
          loss on sale of fixed assets
                                                                 -94,000   -9,000 7,000 17,000                                    
          impairment of long-term investment in related party
                                                                                 107,000 -107,000                        
          gain from operating settlement
                                                                                                          
          purchase of furniture, equipment and leasehold improvements
                                                                  -47,000                                        
          purchase of certain other assets
                                                                                                         
          net proceeds from issuance of common stock due to exercise of stock options and purchase from espp
                                                                  122,000                                        
          proceeds from note payable, net of discount
                                                                     23,000 3,000                                    
          payments on capital lease obligations and notes
                                                                  -4,098,000    -2,000                                    
          other-than-temporary loss on marketable securities
                                                                                                          
          revaluation of warrant liability
                                                                    1,278,000                                      
          net decrease in other assets
                                                                    -4,000                                      
          net proceeds from issuance of common stock and, exercise of stock options and purchases from espp
                                                                    10,000                                      
          payments on capital lease and loan obligations
                                                                    -464,000                                      
          revaluation of warrant
                                                                     -2,375,000                                     
          (purchases)/sales of other assets
                                                                                                          
          net proceeds from issuance of common stock due to exercise of stock options and purchases from espp
                                                                                                          
          issuance cost for credit facility
                                                                                                        
          operating activities:
                                                                                                          
          accounts payable and accrued expenses
                                                                      1,246,000 1,757,000 -3,204,000  1,947,000 1,208,000 -1,876,000  -3,634,000 2,779,000 -3,355,000  1,678,000 3,264,000 -3,295,000  2,312,000 16,000 702,000              436,000  748,000 -419,000 
          investing activities:
                                                                                                          
          increase in other assets
                                                                                                          
          sale of short-term investments
                                                                                                          
          maturities of marketable securities
                                                                      323,000                                    
          financing activities:
                                                                                                          
          net proceeds from issuance of common stock and exercise of stock options
                                                                                                          
          non-cash asset acquisition
                                                                                                          
          purchases and refunds of long-term investments and other assets
                                                                                                          
          net proceeds from issuance of common stock, and exercise of stock options
                                                                                                          
          stock-based compensation to employees
                                                                        325,000    575,000  555,000 406,000 623,000  316,000 511,000 523,000  595,000 786,000 642,000 107,000 99,000              
          unrealized loss on available for sale securities
                                                                        47,000                                  
          maturities of short-term investments
                                                                        471,000 702,000 1,891,000 3,336,000 3,702,000 1,936,000 6,355,000 1,166,000 12,824,000 10,279,000 22,175,000 6,242,000 14,186,000 295,000 7,926,000 17,141,000 10,116,000 4,258,000 5,407,000 -96,000 3,600,000 -386,000 1,589,000 2,321,000 7,942,000 10,932,000 26,916,000 23,133,000 15,540,000 12,866,000 20,886,000 5,611,000 4,976,000 8,475,000 
          net proceeds from issuance of common stock, espp, stock options and restricted stock units
                                                                        190,000    43,000   499,000 717,000    290,000                      
          payments on capital lease obligations
                                                                        -44,000 -3,000    -9,000 -8,000 -8,000 -7,000 -5,000 -28,000 -34,000 -17,000 58,000 -24,000 -55,000 -15,000                 -12,000 
          proceeds from issuance of notes payable
                                                                        4,811,000                                  
          unrealized loss on securities
                                                                                                          
          loss on sale of equipment
                                                                                                          
          deferred gain
                                                                                 -91,000 -495,000  -1,651,000 -582,000 5,753,000                  
          purchases of furniture and equipment
                                                                                                          
          purchases of short-term investments
                                                                             -988,000 -1,297,000 -17,827,000 -11,402,000 -7,795,000 -7,457,000 -20,408,000 -15,451,000                   -988,000 
          sales of short-term investments
                                                                             65,000 -3,995,000 8,221,000 800,000          2,000,000 6,000,000  12,000,000 20,700,000 37,000,000 18,000,000 3,000,000 18,000,000 27,000,000 11,033,000 9,000,000    
          net proceeds from issuance of common stock
                                                                                         288,000 189,000 102,000 114,000 96,000 130,000 333,000 54,166,000 165,000 326,000 287,000 941,000 771,000 76,442,000 919,000 
          proceed from note payable
                                                                                                          
          gain on sales of fixed assets
                                                                                                         
          net proceeds from issuance of common stock, espp, and stock options
                                                                          25,000                                
          proceeds from public offering
                                                                                                          
          proceeds from note payable
                                                                              -1,000                            
          non-cash equity received in satisfaction of milestone and development funding
                                                                                                          
          loan repayments
                                                                                                          
          net income
                                                                                    -6,808,000 3,010,000 -1,788,000 -5,071,000 -930,000 -3,894,000 -1,666,000 -2,761,000 21,385,000          -13,547,000    
          adjustments to reconcile net income to net cash from operating activities:
                                                                                                          
          gain on settlement of loan
                                                                                                          
          accounts receivable and other current assets
                                                                                           4,000 73,000 70,000             
          proceeds from sale of equipment
                                                                                                          
          accrued interest
                                                                                      -326,000  90,000 89,000 57,000  1,495,000 1,498,000 1,500,000 1,500,000 1,500,000 1,417,000       
          net proceeds from issuance of common stock in public offering
                                                                                                          
          repayment of loan
                                                                                      -4,500,000                  
          net proceeds from issuance of common stock public offering
                                                                                        42,353,000                  
          non-cash equity in satisfaction of milestone and development funding
                                                                                                          
          gain on sale of equipment
                                                                                             8,000             
          loss on long-term investment
                                                                                                          
          accrued interest payable
                                                                                                          
          accrued compensation and related expenses
                                                                                                          
          accrued contract research and other accrued expenses
                                                                                                          
          investments in bioone corporation
                                                                                                          
          gain on loan settlement
                                                                                                          
          net proceeds from common stock public offering
                                                                                      19,000                    
          net proceeds from issuance of common stock from espp, stock options and restricted stock units
                                                                                      165,000                    
          increase in cash and cash equivalents
                                                                                      -14,130,000                    
          inventory
                                                                                        -2,068,000                  
          net proceeds from issuance of common stock espp, stock options and restricted stock units
                                                                                        747,000                  
          stock-based compensation to consultants
                                                                                          1,000 11,000             
          accrued contract research expenses
                                                                                                          
          other accrued expenses
                                                                                                          
          loan proceeds
                                                                                                          
          net cash used in operating activities
                                                                                                          
          investment in bioone corporation common stock
                                                                                                          
          accounts receivable from a related party applied to loan payable to a related party
                                                                                              80,000 76,000 62,000          
          accounts receivable from a related party
                                                                                                 -19,000 15,000 25,000       
          accounts payable to a related party
                                                                                                    487,000 3,289,000 92,000 4,585,000 1,460,000 37,000 
          issuance of common stock for services
                                                                                                         
          accrued interest payable to a related party
                                                                                                          
          proceeds from loan payable to a related party
                                                                                                          
          interest paid
                                                                                                          
          investment in bioone corporation
                                                                                                          
          proceeds from loan
                                                                                                  50,000,000       
          net cash provided by financing activities
                                                                                                   50,156,000 318,000 278,000 935,000    
          net increase (decrease) in cash and cash equivalents
                                                                                                   32,912,000      -2,659,000 
          other current assets
                                                                                                         -649,000 
          net cash provided by investing activities
                                                                                                          
          amortization of deferred compensation
                                                                                                          
          accrued cash dividend on preferred stock, payable to a related party
                                                                                                          
          accounts receivable from related a party
                                                                                                       86,000 28,000 90,000 
          net cash from (used in) investing activities
                                                                                                          
          repurchase of common stock